Vanesa Tomas Bosch
Väitöskirjatutkija
vanesa.tomasbosch@uef.fi
My research project is focused on the identification and characterization of novel non-coding RNAs (ncRNAs), in particular long intergenic ncRNAs (lincRNAs), enhancer RNAs (eRNAs), and micro-RNAs (miRNAs) involved in the regulation of Vascular Endothelial Growth Factors (VEGFs) gene expression, and the study of mechanisms by which VEGF-signaling itself regulates the expression of ncRNAs in human endothelial cells. Our study will lay a foundation to decipher the regulatory events that control the developmental and pathological angiogenesis.
Julkaisut
4/4 kappaletta-
Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription
Downes, Nicholas; Niskanen, Henri; Tomas-Bosch, Vanesa; Taipale, Mari; Godiwala, Mehvash; Väänänen, Mari-Anna; Turunen, Tiia A; Aavik, Einari; Laham-Karam, Nihay; Ylä-Herttuala, Seppo; Kaikkonen, Minna U. 2023. Journal of biological chemistry. 299: -
Genomic landscapes of non-coding RNAs regulating VEGFA and VEGFC expression in endothelial cells
Mushimiyimana, Isidore; Tomas Bosch, Vanesa; Niskanen, Henri; Downes, Nicholas; Moreau, Pierre; Hartigan, Kiley; Ylä-Herttuala, Seppo; Laham-Karam, Nihay; Kaikkonen, Minna U.. 2021. Molecular and cellular biology. 41: e00594-20 -
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
Linna-Kuosmanen, Suvi; Bosch, Vanesa Tomas; Moreau, Pierre R; Bouvy-Liivrand, Maria; Niskanen, Henri; Kansanen, Emilia; Kivelä, Annukka; Hartikainen, Juha; Hippeläinen, Mikko; Kokki, Hannu; Tavi, Pasi; Levonen, Anna-Liisa; Kaikkonen, Minna U. 2021. Cardiovascular research. 117: 1339-1357 -
Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types
Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. 2021. Arteriosclerosis, thrombosis, and vascular biology. 41: 2149-2167