Veli-Matti Kosma

A FinnGen pilot clinical recall study for Alzheimer’s disease

Julkunen, Valtteri; Schwarz, Claudia; Kalapudas, Juho; Hallikainen, Merja; Piironen, Aino-Kaisa; Mannermaa, Arto; Kujala, Hanna; Laitinen, Timo; Kosma, Veli-Matti; Paajanen, Teemu I.; Kälviäinen, Reetta; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kärkkäinen, Sari; Kokkola, Tarja; Urjansson, Mia; FinnGen; Perola, Markus; Palotie, Aarno; Vuoksimaa, Eero; Runz, Heiko. 2023. Scientific reports. 13: . 12641

Nuclei instance segmentation from histopathology images using Bayesian dropout based deep learning

Gudhe, Naga Raju; Kosma, Veli-Matti; Behravan, Hamid; Mannermaa, Arto. 2023. Bmc medical imaging. 23: . 162

Predicting cell type counts in whole slide histology images using evidential multi-task learning

Gudhe, Naga Raju; Sudah, Mazen; Mannermaa, Arto; Kosma, Veli-Matti; Behravan, Hamid. Teoksessa: Tomaszewski, John E; Ward, Aaron D(toim.) , 2023. Medical Imaging 2023: Digital and Computational Pathology. s. 239-247. SPIE

A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Wang, Xiaoliang; Chen, Hongjie; Kapoor, Pooja Middha; Su, Yu-Ru; Bolla, Manjeet K.; Dennis, Joe; Dunning, Alison M.; Lush, Michael; Wang, Qin; Michailidou, Kyriaki; Pharoah, Paul D.P.; Hopper, John L.; Southey, Melissa C.; Koutros, Stella; Freeman, Laura E. Beane; Stone, Jennifer; Rennert, Gad; Shibli, Rana; Murphy, Rachel A.; Aronson, Kristan; Guénel, Pascal; Truong, Thérèse; Teras, Lauren R.; Hodge, James M.; Canzian, Federico; Kaaks, Rudolf; Brenner, Hermann; Arndt, Volker; Hoppe, Reiner; Lo,. 2022. Cancer research communications. 2: 211-219

Area-based breast percentage density estimation in mammograms using weight-adaptive multitask learning

Gudhe, Naga Raju; Behravan, Hamid; Sudah, Mazen; Okuma, Hidemi; Vanninen, Ritva; Kosma, Veli-Matti; Mannermaa, Arto. 2022. Scientific reports. 12: . 12060

Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors

Kujala, Jouni; Hartikainen, Jaana M.; Tengström, Maria; Sironen, Reijo; Auvinen, Päivi; Kosma, Veli Matti; Mannermaa, Arto. 2022. Cancers. 14: . 1332

Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies

Jung, Audrey Y; Ahearn, Thomas U; Behrens, Sabine; Middha, Pooja; Bolla, Manjeet K; Wang, Qin; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Beane Freeman, Laura E; Becher, Heiko; Brenner, Hermann; Canzian, Federico; Carey, Lisa A; CTS Consortium; Czene, Kamila; Eliassen, A Heather; Eriksson, Mikael; Evans, D Gareth; Figueroa, Jonine D; Fritschi, Lin; Gabrielson, Marike; Giles, Graham G; Guénel, Pascal; Hadjisavvas, Andreas; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann. 2022. Journal of the national cancer institute. 114: 1706-1719

Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential

Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M.. 2022. Scientific reports. 12: . 22614

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Ruotsalainen, Sanni E.; Surakka, Ida; Mars, Nina; Karjalainen, Juha; Kurki, Mitja; Kanai, Masahiro; Krebs, Kristi; Graham, Sarah; Mishra, Pashupati P.; Mishra, Binisha H.; Sinisalo, Juha; Palta, Priit; Lehtimäki, Terho; Raitakari, Olli; Esko, Tõnu; Metspalu, Andres; Mägi, Reedik; Nelis, Mari; Milani, Lili; Matsuda, Koichi; Yamanashi, Yuji; Furukawa, Yoichi; Morisaki, Takayuki; Murakami, Yoshinori; Kamatani, Yoichiro; Muto, Kaori; Nagai, Akiko; Obara, Wataru; Yamaji, Ken; Takahashi, Kazuhisa; Asa. 2022. Communications biology. 5: . 802

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Tamlander, Max; Mars, Nina; Pirinen, Matti; Palotie, Aarno; Daly, Mark; Riley-Gills, Bridget; Jacob, Howard; Paul, Dirk; Runz, Heiko; John, Sally; Plenge, Robert; Maranville, Joseph; Okafo, George; Lawless, Nathan; Salminen-Mankonen, Heli; McCarthy, Mark; Hunkapiller, Julie; Ehm, Meg; Auro, Kirsi; Longerich, Simonne; Fox, Caroline; Mälarstig, Anders; Klinger, Katherine; Raipal, Deepak; Green, Eric; Graham, Robert; Yang, Robert; O’Donnell, Chris; Mäkelä, Tomi; Kaprio, Jaakko; Virolainen, Petri; H. 2022. Communications biology. 5: . 158

Rare germline copy number variants (CNVs) and breast cancer risk

Dennis, Joe; Tyrer, Jonathan P.; Walker, Logan C.; Michailidou, Kyriaki; Dorling, Leila; Bolla, Manjeet K.; Wang, Qin; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Castelao, Jose E.; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Clarke, Christine L.; Kristensen, . 2022. Communications biology. 5: . 65

A case-only study to identify genetic modifiers ofbreast cancer risk for BRCA1/BRCA2mutationcarriers

Coignard, Juliette; Lush, Michael; Beesley, Jonathan; O'Mara, Tracy A; Dennis, Joe; Tyrer, Jonathan P; Barnes, Daniel R; McGuffog, Lesley; Leslie, Goska; Bolla, Manjeet K; Adank, Muriel A; Agata, Simona; Ahearn, Thomas; Aittomäki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Arnold, Norbert; Aronson, Kristan J.; Arun, Banu K. et al [Incl. Kosma, Veli-Matti; Mannermaa, Arto]. 2021. Nature communications. 12: 1078

Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

Dorling, Leila; Carvalho, Sara; Allen, Jamie; González-Neira, Anna; Luccarini, Craig; Wahlström, Cecilia; Pooley, Karen A.; Parsons, Michael T.; Fortuno, Cristina; Wang, Qin; Bolla, Manjeet K.; Dennis, Joe; Keeman, Renske M.; Alonso, Rosario; Álvarez, Nuria; Herraez, Belen; Fernandez, Victoria; Núñez-Torres, Rocio; Osorio, Ana; Valcich, Jeanette et al. [incl. Hartikainen, Jaana; Kosma, Veli-Matti; Mannermaa, Arto]. 2021. The new england journal of medicine. 384: 428-439

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Johnson, Nichola; Maguire, Sarah; Morra, Anna; Kapoor, Pooja Middha; Tomczyk, Katarzyna; Jones, Michael E; Schoemaker, Minouk J; Gilham, Clare; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Baynes, Caroline; Freeman, Laura E et al. [Incl. Kosma, Veli-Matti; Mannermaa, Arto]. 2021. British journal of cancer. 124: 842-854

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Natarajan, Pradeep; Pampana, Akhil; Graham, Sarah E; Ruotsalainen, Sanni E; Perry, James A; de Vries, Paul S;. Broome, Jai G; Pirruccello, James P; Honigberg, Michael C; Aragam, Krishna; Wolford, Brooke; Brody, Jennifer A; Antonacci-Fulton, Lucinda; Arden, Moscati; Aslibekyan, Stella; Assimes, Themistocles L; Ballantyne, Christie M; Bielak, Lawrence F; Bis, Joshua C.; Cade, Brian E; et al. [incl. FinGen; Kosma, Veli-Matti; Mannermaa, Arto]. 2021. Nature communications. 12: 2182

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Baxter, Joseph S.; Johnson, Nichola; Tomczyk, Katarzyna; Gillespie, Andrea; Maguire, Sarah; Brough, Rachel; Fachal, Laura; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Becher, Heiko; Beckmann, Matthias W. [incl. Kosma, Veli-Matti, Mannermaa, Arto]. 2021. American journal of human genetics. 108: 1190-1203

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Gharahkhani, Puya; Jorgenson, Eric; Hysi, Pirro; Khawaja, Anthony P; Pendergrass, Sarah; Han, Xikun; Ong, Jue Sheng; Hewitt, Alex W; Segrè, Ayellet V; Rouhana, John M; Hamel, Andrew R; Igo, Robert P; Choquet, Helene; Qassim, Ayub; Josyula, Navya S; Cooke Bailey, Jessica N; Bonnemaijer, Pieter W M; Iglesias, Adriana; Siggs, Owen M; Young, Terri L et al. [incl FinGen; Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti]. 2021. Nature communications. 12: 1258

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Zekavat, Seyedeh M.; Lin, Shu-Hong; Bick, Alexander G.; Liu, Aoxing; Paruchuri, Kaavya; Wang, Chen; Uddin, Md Mesbah; Ye, Yixuan; Yu, Zhaolong; Liu, Xiaoxi; Kamatani, Yoichiro; Bhattacharya, Romit; Pirruccello, James P.; Pampana, Akhil; Loh, Po-Ru; Kohli, Puja; McCarroll, Steven A.; Kiryluk, Krzysztof; Neale, Benjamin; Ionita-Laza, Iuliana et al. [incl. Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti]. 2021. Nature medicine. 27: 1012-1024

High Cell-Free DNA Integrity Is Associated with Poor Breast Cancer Survival

Lamminaho, Maria; Kujala, Jouni; Peltonen, Hanna; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto. 2021. Cancers. 13: 4679

Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers

Palomäki, Antti; FinnGen Rheumatology Clinical Expert Group; Palotie, Aarno; Koskela, Jukka; Eklund, Kari K; Pirinen, Matti; FinnGen; Ripatti, Samuli; Laitinen, Tarja; Mars, Nina; [incl. collaborators Kosma, Veli-Matti; Mannermaa, Arto; Heikkinen, Sami]. 2021. Annals of the rheumatic diseases. 80: 1530-1536

Multi-level dilated residual network for biomedical image segmentation

Gudhe, Naga Raju; Behravan, Hamid; Sudah, Mazen; Okuma, Hidemi; Vanninen, Ritva; Kosma, Veli-Matti; Mannermaa, Arto. 2021. Scientific reports. 11: 14105

The debatable presence of PIWI-interacting RNAs in invasive breast cancer

Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M. 2021. Cancer medicine. 10: 3593 - 3603

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fachal, L; Aschard, H; Beesley, J; Barnes, DR; Allen, J; Kar, S; Pooley, KA; Dennis, J; Michailidou, K; Turman, C; Soucy, P; Lemaçon, A; Lush, M; Tyrer, JP; Ghoussaini, M; Marjaneh, MM; Jiang, X; Agata, S; Aittomäki, K; Alonso, MR; et al. [incl. Hartikainen, J; Kosma, VM; Mannermaa, A; Tengström, M]. 2020. Nature genetics. 52: 56-73

High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival

Kujala, J; Hartikainen, JM; Tengström, M; Sironen, R; Kosma, VM; Mannermaa, A. 2020. Cancer medicine. 9: 5922-5931

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Sopo, Minna; Sallinen, Hanna; Hämäläinen, Kirsi; Kivelä, Annukka; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Anttila, Maarit. 2020. PLoS ONE. 15: e0241484

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Bao, Erik L; Nandakumar, Satish K; Liao, Xiaotian; Bick, Alexander G; Karjalainen, J; Tabaka, Marcin; Gan, Olga I; Havulinna, Aki S; Kiiskinen, Tuomo TJ; Lareau, Caleb A; de Lapuente Portilla, Aitzkoa L; Li, Bo; Emdin, Connor; Codd, Veryan; Nelson, Christopher P; Walker, Christopher J; Churchhouse, Claire; de la Chapelle, Albert; Klein, Daryl E; et al. (incl. Kosma, V-M; Heikkinen, S; Mannermaa, A). 2020. Nature. 586: 769-775

MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer

Eneh, Stralina; Heikkinen, Sami; Hartikainen, Jaana M; Kuopio, Teijo; Mecklin, Jukka-Pekka; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Anticancer research. 40: 3713-3722

Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors

Sopo, Minna; Anttila, Maarit; Muukkonen, Oona-Tuuli; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Sallinen, Hanna. 2020. Anticancer research. 40: 6923-6931

Peritumor to Tumor Apparent Diffusion Coefficient Ratio Is Associated With Biologically More Aggressive Breast Cancer Features and Correlates With the Prognostication Tools

Okuma, H; Sudah, M; Kettunen, T; Niukkanen, A; Sutela, A; Masarwah, A; Kosma, VM; Auvinen, P; Mannermaa, A; Vanninen, R. 2020. PLoS ONE. 15: e0235278

Predicting Breast Cancer Risk Using Interacting Genetic and Demographic Factors and Machine Learning

Behravan, Hamid; Hartikainen, Jaana M; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Scientific reports. 10: 11044

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Mars, Nina; Widén, Elisabeth; Kerminen, Sini; Meretoja, Tuomo; Pirinen, Matti; Parolo, Pietro della Briotta; Palta, Priit; FinnGen, Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; Daly, Mark; Ripatti, Samuli [incl. Hiltunen, Mikko; Heikkinen, Sami; Julkunen, Valtteri; Kosma, Veli-Matti; Mannermaa, Arto; Kälviäinen, Reetta]. 2020. Nature communications. 11: 6383

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Shu, Xiang; Wu, Lang; Khankari, Nikhil K; Shu, Xiao-Ou; Wang, Thomas J; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Milne, Roger L; Schmidt, Marjanka K; Pharoah, Paul DP; Andrulis, Irene L; Hunter, David J; Simard, Jacques; Easton, Douglas F; Zheng, Wei; Alicia, Beeghly-Fadiel J; Anton-Culver, Hoda; Antonenkova, Natalia; et al. (Incl. Kosma, Veli-Matti). 2019. International journal of epidemiology. 48: 795-806

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Sopo, M; Anttila, M; Hämäläinen, K; Kivelä, A; Ylä-Herttuala, S; Kosma, VM; Keski-Nisula, L; Sallinen, H. 2019. Bmc cancer. 19: 584

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti; Soininen, Hilkka; Kälviäinen, Reetta). 2019. Nature communications. 10: 4329

Genome-wide association study of germline variants and breast cancer-specific mortality

Escala-Garcia, M; Guo, Q; Dörk, T; Canisius, S; Keeman, R; Dennis, J; Beesley, J; Lecarpentier, J; Bolla, MK; Wang, Q; Abraham, J; Andrulis, IL; Anton-Culver, H; Arndt, V; Auer, PL; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; et al. (Incl. Hartikainen, Jaana; Kosma, Veli-Matti; Mannermaa, Arto; Tengström, Maria). 2019. British journal of cancer. 120: 647-657

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; Beesley, J; Bolla, MK; Shu, X-O; Lu, Y; Cai, Q; Al-Ejeh, F; Rozali, E; Wang, Q; Dennis, J; Li, B; Zeng, C; Feng, H; Gusev, A; Barfield, RT; Andrulis, IL; et al. [Incl Kosma, Veli-Matti; Mannermaa, Arto]. 2018. Nature genetics. 50: 968-978

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

Rudolph, A; Song, M; Brook, MN; Milne, RL; Mavaddat, N; Michailidou, K; Bolla, MK; Wang, Q; Dennis, J; Wilcox, AN; Hopper, JL; Southey, MC; Keeman, R; Fasching, PA; Beckmann, MW; Gago-Dominguez, M; Castelao, JE; Guénel, P; Truong, T; Bojesen, SE; et al. [Incl. Kosma, V-M]. 2018. International journal of epidemiology. 47: 526-536

Machine learning identifies interacting genetic variants contributing to breast cancer risk: a case study in Finnish cases and controls

Behravan, Hamid; Hartikainen, Jaana M; Tengström, Maria; Pylkäs, Katri; Winqvist, Robert; Kosma, Veli-Matti; Mannermaa, Arto. 2018. Scientific reports. 8: 13149

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Mavaddat, N; Michailidou, K; Dennis, J; Lush, M; Fachal, L; Lee, A; Tyrer, JP; Chen, TH; Wang, Q; Bolla, MK; Yang, X; Adank, MA; Ahearn, T; Aittomäki, K; Allen, J; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson KJ; et al [Incl Auvinen, Päivi; Kataja, Vesa; Kosma, Veli-Matti; Mannermaa, Arto]. 2018. American journal of human genetics. 2019; 104: 21-34

The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity

Colombo, M; Lòpez-Perolio, I; Meeks, HD; Caleca, L; Parsons, M; Li, H;, De Vecchi, G; Tudini, E; Foglia, C; Mondini, P; Manoukian, S; Behar, R; Garcia, EBG; Meindl, A; Montagna, M; Niederacher, D; Schmidt, AY; Varesco, L; Wappenschmidt, B; Bolla, M; et al. [Incl Mannermaa, Arto; Kosma, Veli-Matti]. 2018. Human mutation. 39: 729-741

Tumor-infiltrating lymphocytes associate with outcome in non-endemic nasopharyngeal carcinoma : a multicenter study

Almangush, Alhadi; Ruuskanen, Miia; Hagström, Jaana; Hirvikoski, Pasi; Tommola, Satu; Kosma, Veli-Matti; Nieminen, Pentti; Mäkitie, Antti; Leivo, Ilmo. 2018. Human pathology. 81: 211-219

Combined gene therapy using AdsVEGFR2 and AdsTie2 with chemotherapy reduces the growth of human ovarian cancer and formation of ascites in mice

Tuppurainen L, Sallinen H, Karvonen A, Valkonen E, Laakso H, Liimatainen T, Hytönen E, Hämäläinen K, Kosma V-M, Anttila M, Ylä-Herttuala S. 2017. International journal of gynecological cancer. 27: 879-886

FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population

Kiiski JI, Tervasmäki A, Pelttari LM, Khan S, Mantere T, Pylkäs K, Mannermaa A, Tengström M, Kvist A, Borg Å, Kosma V-M, Kallioniemi A, Schleutker J, Bützow R, Blomqvist C, Aittomäki K, Winqvist R, Nevanlinna H. 2017. Breast cancer research and treatment. 166: 217-226

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk

Muranen TA, Greco D, Blomqvist C, Aittomaki K, Khan S, Hogervorst F, Verhoef S, Pharoah PDP, Dunning AM, Shah M, Luben R, Bojesen SE, Nordestgaard BG, Schoemaker M, Swerdlow A, Garcia-Closas M, Figueroa J, Dork T, Bogdanova NV, Hall P et al., NBCS Investigators, KConFab AOCS Investigators, Breast Canc Assoc Consortium. 2017. Genetics in medicine. 19: 599-603

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J et al [incl. Hartikainen Juha, Mannermaa Arto, Tengström Maria]. 2017. Nature genetics. 49: 1767-1778

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

Jiao X, Aravidis C, Marikkannu R, Rantala J, Picelli S, Adamovic T, Liu T, Maguire P, Kremeyer B, Luo L, von Holst S, Kontham V, Thutkawkorapin J, Margolin S, Du Q, Lundin J, Michailidou K, Bolla MK, Wang Q, Dennis J et al.. 2017. Oncotarget. 8: 102769-102782

Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI

Lindgren A, Anttila M, Rautiainen S, Arponen O, Kivelä A, Mäkinen P, Härmä K, Hämäläinen K, Kosma V-M, Ylä-Herttuala S, Vanninen R, Sallinen H. 2017. European radiology. 27: 4002-4012

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study

Brouckaert O, Rudolph A, Laenen A, Keeman R, Bolla MK, Wang Q, Soubry A, Wildiers H, Andrulis IL, Arndt V, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Brauch H, Brennan P, Brenner H, Chenevix-Trench G, Choi JY, Cornelissen S et al.. 2017. Breast cancer research. 19: 119

TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

Fagerholm R, Khan S, Schmidt MK, García-Closas M, Heikkilä P, Saarela J, Beesley J, Jamshidi M, Aittomäki K, Liu J, Ali HR, Andrulis IL, Beckmann MW, Behrens S, Blows FM, Brenner H, Chang-Claude J, Couch FJ, Czene K, Fasching PA et al [Incl Kosma V-M]. 2017. Oncotarget. 8: 18381-18398

Tenascin-C and fibronectin expression divide early stage tongue cancer into low-and high-risk groups

Sundquist E, Kauppila JH, Veijola J, Mroueh R, Lehenkari P, Laitinen S, Risteli J, Soini Y, Kosma V-M, Sawazaki-Calone I, MacEdo CCS, Bloigu R, Coletta RD, Salo T. 2017. British journal of cancer. 116: 640-648

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

Schmidt MK, Hogervorst F, van Hien R, Cornelissen S, Broeks A, Adank MA, Meijers H, Waisfisz Q, Hollestelle A, Schutte M, van den Ouweland A, Hooning M, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Arndt V, Bermisheva M, Bogdanova NV, Bolla MK et al. 2016. Journal of clinical oncology. 34: 2750-60

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, Zhang Y, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Peto J, Dos-Santos-Silva I et al. 2016. Human molecular genetics. 25: 3863-3876

Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, Zhang B, Long J, Shu XO, Schmidt MK, Milne RL, García-Closas M, Chang-Claude J, Lindstrom S, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW et al. 2016. Cancer causes and control. 27: 679-693

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M et al. 2016. Nature genetics. 48: 374-386

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Dennis J, Bolla MK, Wang Q, Dicks E, Milne RL, Hopper JL, Southey MC, Schmidt MK, Broeks A ( incl. Mannermaa Arto, Veli-Matti Kosma). 2016. American journal of human genetics. 99: 903-911

FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome

Kiiski JI, Fagerholm R, Tervasmäki A, Pelttari LM, Khan S, Jamshidi M, Mantere T, Pylkäs K, Bartek J, Bartkova J, Mannermaa A, Tengström M, Kosma VM, Winqvist R, Kallioniemi A, Aittomäki K, Blomqvist C, Nevanlinna H. 2016. International journal of cancer. 139: 2760-2770

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Darabi H, Beesley J, Droit A, Kar S, Nord S, Moradi Marjaneh M, Soucy P, Michailidou K, Ghoussaini M, Fues Wahl H, Bolla MK, Wang Q, Dennis J, Alonso MR, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV et al (incl Kosma Veli-matti, Mannermaa Arto). 2016. Scientific reports. 6: 32512

Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus

Horne HN, Chung CC, Zhang H, Yu K, Prokunina-Olsson L, Michailidou K, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O, Johnson N, Sawyer EJ, Tomlinson I et al. (Incl. Kosma Veli-Matti, Mannermaa Arto). 2016. PLoS ONE. 11: e0160316

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer

Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Dennis J, Lush M, Milne RL, Shu XO, Beesley J, Kar S, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Zhao Z, Guo X, Benitez J et al. 2016. International journal of cancer. 139: 1303-1317

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q, Delgado MK, Lee JM, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Bandera EV, Barile M, Barkardottir RB et al (incl Kosma Veli-Matti, Mannermaa Arto). 2016. Nature communications. 7: 12675

Genes associated with histopathologic features of triple negative breast tumors predict molecular subtypes

Purrington KS, Visscher DW, Wang C, Yannoukakos D, Hamann U, Nevanlinna H, Cox A, Giles GG, Eckel-Passow JE, Lakis S, Kotoula V, Fountzilas G, Kabisch M, Rüdiger T, Heikkilä P, Blomqvist C, Cross SS, Southey MC, Olson JE, Gilbert J et al. 2016. Breast cancer research and treatment. 157: 117-131

Genetic predisposition to ductal carcinoma in situ of the breast

Petridis Christos, Brook Mark N, Shah Vandna, Kohut Kelly, Gorman Patricia, Caneppele Michele, Levi Dina, Papouli Efterpi, Orr Nick, Cox Angela, Cross Simon S, Dos-Santos-Silva Isabel, Peto Julian, Swerdlow Anthony, Schoemaker Minouk J, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Benitez Javier et al. 2016. Breast cancer research. 18: 22

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Guo Y, Warren Andersen S, Shu XO, Michailidou K, Bolla MK, Wang Q, Garcia-Closas M, Milne RL, Schmidt MK, Chang-Claude J, Dunning A, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J et al. (incl. Kosma Veli-Matti, Mannermaa Arto). 2016. PLoS medicine. 13: e1002105

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Kar SP, Beesley J, Amin Al Olama A, Michailidou K, Tyrer J, Kote-Jarai Z, Lawrenson K, Lindstrom S, Ramus SJ, Thompson DJ, ABCTB Investigators, Kibel AS, Dansonka-Mieszkowska A, Michael A, Dieffenbach AK, Gentry-Maharaj A, Whittemore AS, Wolk A, Monteiro A, Peixoto A et al (incl. Kosma Veli-Matti). 2016. Cancer discovery. 6: 1052-1067

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

Tiainen Satu, Oikari Sanna, Tammi Markku, Rilla Kirsi, Hämäläinen Kirsi, Tammi Raija, Kosma Veli-Matti, Auvinen Päivi. 2016. Breast cancer research and treatment. 160: 237-247

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Couch Fergus J, Kuchenbaecker Karoline B, Michailidou Kyriaki, Mendoza-Fandino Gustavo A, Nord Silje, Lilyquist Janna, Olswold Curtis, Hallberg Emily, Agata Simona, Ahsan Habibul, Aittomäki Kristiina, Ambrosone Christine, Andrulis Irene L, Anton-Culver Hoda, Arndt Volker, Arun Banu K, Arver Brita, Barile Monica, Barkardottir Rosa B, Barrowdale Daniel et al. 2016. Nature communications. 7: 11375

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Consortium of Modifiers of BRCA1 and BRCA2, Hollestelle Antoinette, van der Baan Frederieke H, Berchuck Andrew, Johnatty Sharon E, Aben Katja K, Agnarsson Bjarni A, Aittomäki Kristiina, Alducci Elisa, Andrulis Irene L, Anton-Culver Hoda, Antonenkova Natalia N, Antoniou Antonis C, Apicella Carmel, Arndt Volker, Arnold Norbert, Arun Banu K, Arver Brita, Ashworth Alan, Baglietto Laura, Balleine Rosemary et al. (incl. Jaana. 2016. Gynecologic oncology. 141: 386-401

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

Easton Douglas F, Lesueur Fabienne, Decker Brennan, Michailidou Kyriaki, Li Jun, Allen Jamie, Luccarini Craig, Pooley Karen A, Shah Mitul, Bolla Manjeet K, Wang Qin, Dennis Joe, Ahmad Jamil, Thompson Ella R, Damiola Francesca, Pertesi Maroulio, Voegele Catherine, Mebirouk Noura, Robinot Nivonirina, Durand Geoffrey et al. 2016. Journal of medical genetics. 53: 298-309

PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS

Southey MC, Goldgar DE, Winqvist R, Pylkäs K, Couch F, Tischkowitz M, Foulkes WD, Dennis J, Michailidou K, van Rensburg EJ, Heikkinen T, Nevanlinna H, Hopper JL, Dörk T, Claes KB, Reis-Filho J, Teo ZL, Radice P, Catucci I, Peterlongo P et al. 2016. Journal of medical genetics. 53: 800-811

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

Masarwah Amro, Auvinen Päivi, Sudah Mazen, Dabravolskaite Vaiva, Arponen Otso, Sutela Anna, Oikari Sanna, Kosma Veli-Matti, Vanninen Ritva. 2016. Bmc cancer. 16: 833

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk

Liu J, Loncar I, Collée JM, Bolla MK, Dennis J, Michailidou K, Wang Q, Andrulis IL, Barile M, Beckmann MW, Behrens S, Benitez J, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Brauch H, Brennan P, Brenner H, Broeks A et al. (incl. Mannermaa Arto, Kosma Veli-Matti). 2016. Scientific reports. 6: 36874

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Seibold Petra, Schmezer Peter, Behrens Sabine, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Flesch-Janys Dieter, Nevanlinna Heli, Fagerholm Rainer, Aittomäki Kristiina, Blomqvist Carl, Margolin Sara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Lambrechts Diether, Wildiers Hans, Kristensen Vessela, Alnæs Grethe Grenaker et al. 2015. Bmc cancer. 15: 978

A simple novel prognostic model for early stage oral tongue cancer

Almangush A, Coletta RD, Bello IO, Bitu C, Keski-Säntti H, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Tommola S, Soini Y, Kosma V-M, Koivunen P, Kowalski LP, Nieminen P, Grénman R, Leivo I, Salo T. 2015. International journal of oral and maxillofacial surgery. 44: 143-150

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

Sobral-Leite Marcelo, Wesseling Jelle, Smit Vincent THBM, Nevanlinna Heli, van Miltenburg Martine H, Sanders Joyce, Hofland Ingrid, Blows Fiona M, Coulson Penny, Patrycja Gazinska, Schellens Jan HM, Fagerholm Rainer, Heikkilä Päivi, Aittomäki Kristiina, Blomqvist Carl, Provenzano Elena, Ali Hamid Raza, Figueroa Jonine, Sherman Mark, Lissowska Jolanta et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Bmc medicine. 13: 156

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Lei Jieping, Rudolph Anja, Moysich Kirsten B, Rafiq Sajjad, Behrens Sabine, Goode Ellen L, Pharoah Paul PD, Seibold Petra, Fasching Peter A, Andrulis Irene L, Kristensen Vessela N, Couch Fergus J, Hamann Ute, Hooning Maartje J, Nevanlinna Heli, Eilber Ursula, Bolla Manjeet K, Dennis Joe, Wang Qin, Lindblom Annika et al (incl. Mannermaa Arto, Kosma Veli-Matti, Hartikainen Jaana M, Kataja Vesa). 2015. Breast cancer research. 17: -

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

Meeks Huong D, Song Honglin, Michailidou Kyriaki, Bolla Manjeet K, Dennis Joe, Wang Qin, Barrowdale Daniel, Frost Debra, McGuffog Lesley, Ellis Steve, Feng Bingjian, Buys Saundra S, Hopper John L, Southey Melissa C, Tesoriero Andrea, James Paul A, Bruinsma Fiona, Campbell Ian G, Broeks Annegien, Schmidt Marjanka K et al. 2015. Journal of the national cancer institute. 108: djv315

Common germline polymorphisms associated with breast cancer specific survival

Pirie Ailith, Guo Qi, Kraft Peter, Canisius Sander, Eccles Diana M, Rahman Nazneen, Nevanlinna Heli, Chen Constance, Khan Sofia, Tyrer Jonathan, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Lush Michael, Dunning Alison M, Shah Mitul, Czene Kamila, Darabi Hatef, Eriksson Mikael et al (incl. Vesa Kataja, Jaana Hartikainen, Veli-Matti Kosma). 2015. Breast cancer research. 17: -

Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer

Nykopp Timo K, Pasonen-Seppänen Sanna, Tammi Markku I, Tammi Raija H, Kosma Veli-Matti, Anttila Maarit, Sironen Reijo. 2015. Gynecologic oncology. 137: 152-159

Diffusion-Weighted Imaging in 3.0 Tesla Breast MRI: Diagnostic Performance and Tumor Characterization Using Small Subregions vs. Whole Tumor Regions of Interest

Arponen Otso, Sudah Mazen, Masarwah Amro, Taina Mikko, Rautiainen Suvi, Könönen Mervi, Sironen Reijo, Kosma Veli-Matti, Sutela Anna, Hakumäki Juhana, Vanninen Ritva. 2015. PLoS ONE. 10: e0138702

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Guo X, Long J, Zeng C, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Milne RL, Shu XO, Cai Q, Beesley J, Kar SP, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Blot W, Bogdanova N et al.. 2015. Cancer epidemiology biomarkers and prevention. 24: -

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2

Orr Nick, Dudbridge Frank, Dryden Nicola, Maguire Sarah, Novo Daniela, Perrakis Eleni, Johnson Nichola, Ghoussaini Maya, Hopper John L, Southey Melissa C, Apicella Carmel, Stone Jennifer, Schmidt Marjanka K, Broeks Annegien, Van't Veer Laura J, Hogervorst Frans B, Fasching Peter A, Haeberle Lothar, Ekici Arif B, Beckmann Matthias W et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Human molecular genetics. 24: 2966-2984

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

Glubb Dylan M, Maranian Mel J, Michailidou Kyriaki, Pooley Karen A, Meyer Kerstin B, Kar Siddhartha, Carlebur Saskia, O'Reilly Martin, Betts Joshua A, Hillman Kristine M, Kaufmann Susanne, Beesley Jonathan, Canisius Sander, Hopper John L, Southey Melissa C, Tsimiklis Helen, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Hogervorst Frans B et al (incl. Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti KosmaI). 2015. American journal of human genetics. 96: 5-20

For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality

Almangush Alhadi, Bello Ibrahim O, Coletta Ricardo D, Mäkitie Antti A, Mäkinen Laura K, Kauppila Joonas H, Pukkila Matti, Hagström Jaana, Laranne Jussi, Soini Ylermi, Kosma Veli-Matti, Koivunen Petri, Kelner Natalie, Kowalski Luiz Paulo, Grénman Reidar, Leivo Ilmo, Läärä Esa, Salo Tuula. 2015. Virchows archiv. 467: 39-46

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Michailidou Kyriaki, Beesley Jonathan, Lindstrom Sara, Canisius Sander, Dennis Joe, Lush Michael J, Maranian Mel J, Bolla Manjeet K, Wang Qin, Shah Mitul, Perkins Barbara J, Czene Kamila, Eriksson Mikael, Darabi Hatef, Brand Judith S, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Nielsen Sune F, Rahman Nazneen et al (incl. Arto Mannermaa, Jaana Hartikainen, Veli-Matti Kosma, Vesa Kataja). 2015. Nature genetics. 47: 373-380

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

Zhang Ben, Shu Xiao-Ou, Delahanty Ryan J, Zeng Chenjie, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Wen Wanqing, Long Jirong, Li Chun, Dunning Alison M, Chang-Claude Jenny, Shah Mitul, Perkins Barbara J, Czene Kamila, Darabi Hatef, Eriksson Mikael, Bojesen Stig E, Nordestgaard Børge G et al. (incl. Mannermaa A, Kataja V, Kosma V-M, Hartikainen JM). 2015. Journal of the national cancer institute. 107: djv219

Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers

Sung Hyuna, Garcia-Closas Montserrat, Chang-Claude Jenny, Blows Fiona M, Ali H Raza, Figueroa Jonine, Nevanlinna Heli, Fagerholm Rainer, Heikkilä Päivi, Blomqvist Carl, Giles Graham G, Milne Roger L, Southey Melissa C, McLean Catriona, Mannermaa Arto, Kosma Veli-Matti, Kataja Vesa, Sironen Reijo, Couch Fergus J, Olson Janet E et al. 2015. British journal of cancer. 114 (02 February 2016): 298-304

Identification of Novel Genetic Markers of Breast Cancer Survival

Guo Qi, Schmidt Marjanka K, Kraft Peter, Canisius Sander, Chen Constance, Khan Sofia, Tyrer Jonathan, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Lush Michael, Kar Siddhartha, Beesley Jonathan, Dunning Alison M, Shah Mitul, Czene Kamila, Darabi Hatef, Eriksson Mikael, Lambrechts Diether et al. (incl. Mannermaa Arto). 2015. Journal of the national cancer institute. 107: djv081

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer

Kabisch Maria, Bermejo Justo Lorenzo, Dünnebier Thomas, Ying Shibo, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Shah Mitul, Perkins Barbara J, Czene Kamila, Darabi Hatef, Eriksson Mikael, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Lambrechts Diether, Neven Patrick, Peeters Stephanie et al (incl.. 2015. Carcinogenesis. 36: 256-271

KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes

Hartikainen Jaana M, Tengström Maria, Winqvist Robert, Jukkola-Vuorinen Arja, Pylkäs Katri, Kosma Veli-Matti, Soini Ylermi, Mannermaa Arto. 2015. Clinical cancer research. 21: -

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Day Felix R, Ruth Katherine S, Thompson Deborah J, Lunetta Kathryn L, Pervjakova Natalia, Chasman Daniel I, Stolk Lisette, Finucane Hilary K, Sulem Patrick, Bulik-Sullivan Brendan, Esko Tõnu, Johnson Andrew D, Elks Cathy E, Franceschini Nora, He Chunyan, Altmaier Elisabeth, Brody Jennifer A, Franke Lude L, Huffman Jennifer E, Keller Margaux F et al.. 2015. Nature genetics. 47: 1294-1303

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair: editorial comment

Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF et al. 2015. Obstetrical and gynecological survey. 70: 758-762

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival

Pelkonen Mikko, Luostari Kaisa, Tengström Maria, Ahonen Hermanni, Berdel Bozena, Kataja Vesa, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto. 2015. Bmc cancer. 15: -

Negligible respiratory irritation and inflammation potency of pigmentary TiO2 in mice

Leppänen Maija, Korpi Anne, Yli-Pirilä Pasi, Lehto Maili, Wolff Henrik, Kosma Veli-Matti, Alenius Harri, Pasanen Pertti. 2015. Inhalation toxicology. 27: 378-386

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

Hatef Darabi, Karen McCue, Jonathan Beesley, Kyriaki Michailidou, Silje Nord,Siddhartha Kar, Keith Humphreys, Deborah Thompson, Maya Ghoussaini, Manjeet K. Bolla, Joe Dennis, Qin Wang, Sander Canisius, Christopher G. Scott, Carmel Apicella, John L. Hopper, Melissa C. Southey, Jennifer Stone, Annegien Broeks, Marjanka K. Schmidt et al (incl. Veli-Matti Kosma, Arto Mannermaa). 2015. American journal of human genetics. 97: 22-34

Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

Mavaddat Nasim, Pharoah Paul DP, Michailidou Kyriaki, Tyrer Jonathan, Brook Mark N, Bolla Manjeet K, Wang Qin, Dennis Joe, Dunning Alison M, Shah Mitul, Luben Robert, Brown Judith, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Czene Kamila, Darabi Hatef, Eriksson Mikael, Peto Julian et al (incl. Arto Mannermaa). 2015. Journal of the national cancer institute. 107: djv036

SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma

Jouppila-Mättö Anna, Mannermaa Arto, Sironen Reijo, Kosma Veli-Matti, Soini Ylermi, Pukkila Matti. 2015. Histology and histopathology. 30: 569-579

SNP-SNP interaction analysis of NF-kappaB signaling pathway on breast cancer survival

Jamshidi Maral, Fagerholm Rainer, Khan Sofia, Aittomäki Kristiina, Czene Kamila, Darabi Hatef, Li Jingmei, Andrulis Irene L, Chang-Claude Jenny, Devilee Peter, Fasching Peter A, Michailidou Kyriaki, Bolla Manjeet K, Dennis Joe, Wang Qin, Guo Qi, Rhenius Valerie, Cornelissen Sten, Rudolph Anja, Knight Julia A et al. 2015. Oncotarget. 6: 37979-37994

The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome

Masarwah Amro, Tammi Markku, Sudah Mazen, Sutela Anna, Oikari Sanna, Kosma Veli-Matti, Tammi Raija, Vanninen R, Auvinen Päivi. 2015. Breast cancer research and treatment. 153: 625-634

Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer

Masarwah Amro, Auvinen Päivi, Sudah Mazen, Rautiainen Suvi, Sutela Anna, Pelkonen Outi, Oikari Sanna, Kosma Veli-Matti, Vanninen Ritva. 2015. European radiology. 25: 1875-1882

Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function

Virtakoivu Reetta, Mai Anja, Mattila Elina, De Franceschi Nicola, Imanishi Susumu Y., Corthals Garry, Kaukonen Riina, Saari Markku, Cheng Fang, Torvaldson Elin, Kosma Veli-Matti, Mannermaa Arto, Muharram Ghaffar, Gilles Christine, Eriksson John, Soini Ylermi, Lorens James B., Ivaska Johanna. 2015. Cancer research. 75: 2349-2362

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Li Jingmei, Lindström Linda S, Foo Jia N, Rafiq Sajjad, Schmidt Marjanka K, Pharoah Paul DP, Michailidou Kyriaki, Dennis Joe, Bolla Manjeet K, Wang Qin, Van 't Veer Laura J, Cornelissen Sten, Rutgers Emiel, Southey Melissa C, Apicella Carmen, Dite Gillian S, Hopper John S, Fasching Peter A, Haeberle Lothar, Ekici Arif B et al. 2014. Nature communications. : 4051

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium

Milne RL, Herranz J, Michailidou K, Dennis J, Tyrer JP, Zamora MP, Arias-Perez JI, González-Neira A, Pita G, Alonso MR, Wang Q, Bolla MK, Czene K, Eriksson M, Humphreys K, Darabi H,..., Mannermaa A, Kataja V, Kosma VM, Hartikainen J, et al.. 2014. Human molecular genetics. 23: 1934-1946

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium

Milne RL, Burwinkel B, Michailidou K, Arias-Perez JI, Zamora MP, Menéndez-Rodríguez P, Hardisson D, Mendiola M, González-Neira A, Pita G, Alonso MR, Dennis J, Wang Q, Bolla MK, Swerdlow A, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. Human molecular genetics. 23: 6096-6111

Depth of invasion, tumor budding and worst pattern of invasion: Prognostic indicators in early-stage oral tongue cancer

Almangush Alhadi, Bello Ibrahim O, Keski-Säntti Harri, Mäkinen Laura K, Kauppila Joonas H, Pukkila Matti, Hagström Jaana, Laranne Jussi, Tommola Satu, Nieminen Outi, Soini Ylermi, Kosma Veli-Matti, Koivunen Petri, Grénman Reidar, Leivo Ilmo, Salo Tuula. 2014. Head and neck: journal for the sciences and specialties of the head and neck. 36: 811-818

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. Nature communications. 4: Article number:4999

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT, Mannermaa A, Kataja V, Kosma V-M, Hartikainen J, Easton DF, Pharoah PDP, Arias-Perez JI, Zamora P, Benitez J, Milne RL et.al. 2014. British journal of cancer. 110: 1088-1100

Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer

Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen JM, Kosma VM, Laasanen SL, Mannermaa A, Pylkäs K, Winqvist R. 2014. Clinical genetics. 88: 68-73

Genetic predisposition to in situ and invasive lobular carcinoma of the breast

Sawyer Elinor, Roylance Rebecca, Petridis Christos, Brook Mark N, Nowinski Salpie, Papouli Efterpi, Fletcher Olivia, Pinder Sarah, Hanby Andrew, Kohut Kelly, Gorman Patricia, Caneppele Michele, Peto Julian, dos Santos Silva Isabel, Johnson Nichola, Swann Ruth, Dwek Miriam, Perkins Katherine-Anne, Gillett Cheryl, Houlston Richard et al (incl. Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M,). 2014. PLoS genetics. 10: e1004285

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Johnson Nichola, Dudbridge Frank, Orr Nick, Gibson Lorna, Jones Michael E, Schoemaker Minouk J, Folkerd Elizabeth J, Haynes Ben P, Hopper John L, Southey Melissa C, Dite Gillian S, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Van T Veer Laura J, Atsma Femke et al. 2014. Breast cancer research and treatment. 16: R51

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

Purrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P, Carpenter J, Yannoukakos D, Haiman CA, Fasching PA, Mannermaa A, ...,Hartikainen JM, Kosma VM, Kataja V, et al.. 2014. Human molecular genetics. 23: 6034-6046

Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple negative breast cancer

Purrington Kristen S, Slager Susan, Eccles Diana, Yannoukakos Drakoulis, Fasching Peter A, Miron Penelope, Carpenter Jane, Chang-Claude Jenny, Martin Nicholas G, Montgomery Grant W, Kristensen Vessela, Anton-Culver Hoda, Goodfellow Paul, Tapper William J, Rafiq Sajjad, Gerty Susan M, Durcan Lorraine, Konstantopoulou Irene, Fostira Florentia, Vratimos Athanassios et.al. (including Kosma Veli-Matti, Mannermaa Arto). 2014. Carcinogenesis. 35: 1012-1019

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

Tiainen Satu, Tumelius Ritva, Rilla Kirsi, Hämäläinen Kirsi, Tammi Markku, Tammi Raija, Kosma Veli-Matti, Oikari Sanna, Auvinen Päivi. 2014. Histopathology. 2014; 66: 873-883

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Breast cancer research and treatment. 143: 277-286

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL, Apicella C, Southey MC, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Th Rutgers EJ, Muir K, Lophatananon A, Stewart-Brown S, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, kConFab Investigators; Australian Ovarian Cancer Study Group, et al.. 2014. Human molecular genetics. 2014: 1-14

Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions

Schoeps Anja, Rudolph Anja, Seibold Petra, Dunning Alison M, Milne Roger L, Bojesen Stig E, Swerdlow Anthony, Andrulis Irene, Brenner Hermann, Behrens Sabine, Orr Nicholas, Jones Michael, Ashworth Alan, Li Jingmei, Cramp Helen, Connley Dan, Czene Kamila, Darabi Hatef, Chanock Stephen J, Lissowska Jolanta et al (incl Kosma Veli-Matti, Kataja Vesa, Hartikainen Jaana M, Mannermaa Arto). 2014. Genetic epidemiology. 38: 84-93

Inhaled silica-coated TiO2 nanoparticles induced airway irritation, airflow limitation and inflammation in mice

Leppänen Maija, Korpi Anne, Mikkonen Santtu, Yli-Pirilä Pasi, Lehto Maili, Pylkkänen Lea, Wolff Henrik, Kosma Veli-Matti, Alenius Harri, Joutsensaari Jorma, Pasanen Pertti. 2014. Nanotoxicology. 2015; 9: 210-218

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Rudolph A, Milne RL, Truong T, Knight JA, Seibold P, Flesch-Janys D, Behrens S, Eilber U, Bolla MK, Wang Q, Dennis J, Dunning AM, Shah M, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. International journal of cancer. 136: E685-E696

MicroRNA Related Polymorphisms and Breast Cancer Risk

Khan Sofia, Greco Dari, Michailidou Kyriaki, Milne Roger L, Muranen Taru A, Heikkinen Tuomas, Aaltonen Kirsimari, Dennis Joe, Bolla Manjeet K, Liu Jianjun, Hall Per, Irwanto Astrid, Humphreys Keith, Li Jingmei, Czene Kamila, Chang-Claude Jenny, Hein Rebecca, Rudolp Anja, Seibold Petra, Flesch-Janys Dieter et at (including Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Mannermaa Arto). 2014. PLoS ONE. 9: e109973 (1-12)

MnSOD rs4880 and XPD rs13181 polymorphisms predict the survival of breast cancer patients treated with adjuvant tamoxifen

Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Soini Ylermi, Hirvonen Ari, Kataja Vesa. 2014. Acta oncologica. 53: 769-775

Overexpression of MicroRNA-200c Predicts Poor Outcome in Patients with PR-Negative Breast Cancer

Tuomarila M, Luostari K, Soini Y, Kataja V, Kosma VM, Mannermaa A. 2014. PLoS ONE. 9: e109508: 1-8

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry John RB, Day Felix, Elks Cathy E, Sulem Patrick, Thompson Deborah J, Ferreira Teresa, He Chunyan, Chasman Daniel I, Esko Tõnu, Thorleifsson Gudmar, Albrecht Eva, Ang Wei Q, Corre Tanguy, Cousminer Diana L, Feenstra Bjarke, Franceschini Nora, Ganna Andrea, Johnson Andrew D, Kjellqvist Sanela, Lunetta Kathryn L et al. 2014. Nature. 514: 92-97

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Spurdle Amanda B, Couch Fergus J, Parsons Michael T, McGuffog Lesley, Barrowdale Daniel, Bolla Manjeet K, Wang Qin, Healey Sue, Schmutzler Rita Katharina, Wappenschmidt Barbara, Rhiem Kerstin, Hahnen Eric, Engel Christoph, Meindl Alfons, Ditsch Nina, Norbert Arnold, Plendl Hansjoerg, Niede et al. (incl. Hartikainen Jaana)racher Dieter, Sutter Christian, Wang-Gohrke Shan,. 2014. Breast cancer research. 16: 3419

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

Sallinen H, Heikura T, Koponen J, Kosma VM, Heinonen S, Ylä-Herttuala S, Anttila M. 2014. Bmc cancer. 14: 1-10

Type II Transmembrane Serine Protease Gene Variants Associate with Breast Cancer

Luostari Kaisa, Hartikainen Jaana M, Tengström Maria, Palvimo Jorma J, Kataja Vesa, Mannermaa Arto, Kosma Veli-Matti. 2014. PLoS ONE. 9: e102519

XRCC1 rs25487 polymorphism predicts the survival of patients after postoperative radiotherapy and adjuvant chemotherapy for breast cancer

Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Hirvonen Ari, Kataja Vesa. 2014. Anticancer research. 34: 3031-3037

&#947 -Secretase Components as Predictors of Breast Cancer Outcome

Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A. 2013. PLoS ONE. 8: e79249, 1-13

A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication

Hein R, Flesch-Janys D, Dahmen N, Beckmann L, Lindström S, Schoof N, Czene K, Mittelstraß K, Illig T, Seibold P, Behrens S, Humphreys K, Li J, Liu J, Olson et al. 2013. Breast cancer research and treatment. 138: 529-42

Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.

Nickels S, Truong T, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt M, Häberle L, Vrieling A, Gaudet M, Figueroa J, Schoof N, Spurdle AB, Rudolph A, Fasching PA, Hopper JL, Makalic E, Schmidt DF, Southey MC, Beckmann MW, Ekici AB, Fletcher O, Gibson L, Silva Idos S, Peto J, Humphreys MK, Wang J, Cordina-Duverger E, Menegaux F, Nordestgaard BG, Bojesen SE, Lanng C, Anton-Culver H, Ziogas A, Bernstein L, Clarke CA, Brenner H, Müller H, Arndt V, Stegmaier C, Brauch H, Brüning T, Harth V; G. 2013. PLoS genetics. 9: e1003284

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1

Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD, Prathalingham R, Dennis J, Bolla MK, Wang Q, de Santiago I, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Schmidt MK, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2013. American journal of human genetics. 93: 1046-1060

Functional MRI Measurements to Predict Early Adenoviral Gene Therapy Response in Ovarian Cancer Mouse Model

Tuppurainen L, Sallinen H, Hakkarainen H, Liimatainen T, Hassan M, Ylä-Herttuala E, Anttila M, Hämäläinen K, Veli-Matti Kosma, Heinonen S, Alitalo K, Ylä-Herttuala S. 2013. Journal of genetic syndromes & gene therapy. 4: x-x

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S, Khan S, Maranian MJ, O'Reilly M, Hillman KM, Betts JA, Carroll T, Bailey PJ, Dicks E et.al.. 2013. American journal of human genetics. 92: 489-503

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le Marchand L, Buring JE, Eccles D, et. al. 2013. Nature genetics. 45: 392-8

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A et. al. 2013. Nature genetics. 45: 353-61

Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer

Tuhkanen H, Hartikainen JM, Soini Y, Velasco G, Sironen R, Nykopp TK, Kataja V, Eskelinen M, Kosma VM, Mannermaa A.. 2013. International journal of cancer. 133: 2334-2340

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz et al. 2013. Nature genetics. 45: 371-84

Pathology at the interface of basic and clinical research

Carpén O, Kosma VM. 2013. Duodecim. 129: 1080-7

Preclinical Safety, Toxicology, and Biodistribution Study of Adenoviral Gene Therapy with sVEGFR-2 and sVEGFR-3 Combined with Chemotherapy for Ovarian Cancer

Tuppurainen L, Sallinen H, Kokki E, Koponen J, Anttila M, Pulkkinen K, Heikura T, Toivanen P, Hämäläinen K, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2013. Human gene therapy. clinical development. 24: 29-37

The UGT1A6_19_GG genotype is a breast cancer risk factor

Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V, Pesch B, Brüning T, Baisch C, Hartikainen JM, Mannermaa A, Kosma VM, Kataja V, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Fasching PA, Beckmann M, Ekici AB, Hein A, Hall P, Li J, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Hamann U, Ko YD, Brauch H. & al.. 2013. Frontiers in genetics. 4: 1-6

11q13 is a susceptibility locus for hormone receptor positive breast cancer

Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI et.al.. 2012. Human mutation. 33: 1123-1132

19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus

Stevens Kristen N, Fredericksen Zachary, Vachon Celine M, Wang Xianshu, Margolin Sara, Lindblom Annika, Nevanlinna Heli, Greco Dario, Aittomäki Kristiina, Blomqvist Carl, Chang-Claude Jenny, Vrieling Alina, Flesch-Janys Dieter, Sinn Hans-Peter, Wang-Gohrke Shan, Nickels Stefan, Brauch Hiltrud, Ko Yon-Dschun, Fischer Hans-Peter, Schmutzler Rita K. 2012. Cancer research. 72: 1795-1803

9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Warren H, Dudbridge F, Fletcher O, Orr N, Johnson N, Hopper JL, Apicella C, Southey MC, Mahmoodi M, Schmidt MK, Broeks A, Cornelissen S, Braaf LM, Muir KR, Lophatananon A, Chaiwerawattana A, Wiangnon S, Fasching PA, Beckmann MW, Ekici AB et al. 2012. Cancer epidemiology biomarkers and prevention. 21: 1783-1791

Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma

Sopo M, Anttila M, Sallinen H, Tuppurainen L, Laurema A, Laidinen S, Hamalainen K, Tuunanen P, Koponen JK, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. 2012. International journal of cancer. 131: 234-2401

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Kirchhoff T, Gaudet MM, Antoniou AC, McGuffog L, Humphreys MK, Dunning AM, Bojesen SE, Nordestgaard BG, Flyger H, Kang D, Yoo KY, Noh DY, Ahn SH, Dork T, Schürmann P, Karstens JH, Hillemanns P, Couch FJ, Olson J, Vachon C, et.al.. 2012. PLoS ONE. 7: e35706

Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions

Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R.. 2012. Science translational medicine. 4: 122-123

Bronkiaalinen karsinoidituumori

Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 556-557. Kustannus Oy Duodecim

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer

Weischer M, Nordestgaard BG, Pharoah P, Bolla MK, Nevanlinna H, van't Veer LJ, Garcia-Closas M, Jopper JL, Hall P, Andrulis IL, Devilee P, Fasching PA, Anton-Culver H, Lambrechts D, Hooning M, Cox A, Giles GG, Burwinkel B, Lindblom A, Couch FJ et.al.. 2012. Journal of clinical oncology. 30: 4308-16

Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association consortium (BCAC)

Hein R, Maranian M, Hopper J L, Kapuscinski M K, Southey M C, Park D J, Schmidt M K, Broeks A, Hogervorst F B L, Bueno-de-Mesquit H B, Muir K R, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching P A, Hein A, Ekici A B, Beckmann M W, Fletcher O, Johnson N, et.al.. 2012. PLoS ONE. 7: -

Energia-aineenvaihduntaan vaikuttavat aineet

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 130. Duodecim

Fibrinoidi nekroosi

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143. Kustannus Oy Duodecim

Genetic Polymorphisms and Protein Expression of NRF2 and Sulfiredoxin Predict Survival Outcomes in Breast Cancer

Hartikainen JM,Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y.. 2012. Cancer research. 72: 5537-5546

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Drive K, Johnson N, Orr N, Dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, et al. 2012. Nature genetics. 44: 312-318

Genotoksiset ja karsinogeeniset aineet

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 122-123. Kustannus Oy Duodecim

Glykogeenikertymät

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 147. Kustannus Oy Duodecim

Histone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer.

Berdel B, Nieminen K, Soini Y, Tengström M, Malinen M, Kosma VM, Palvimo J, Mannermaa A. 2012. Bmc cancer. 12: e1-15

Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer

Auvinen P, Tammi R, Kosma VM, Sironen R, Soini Y, Mannermaa A, Tumelius R, Uljas E, Tammi M. 2012. International journal of cancer. 132: 531-539

Iskeeminen soluvaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 131-133. Kustannus Oy Duodecim

Juustonekroosi

Nukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 142. Kustannus Oy Duodecim

Kemiallinen solvaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 134-135. Kustannus Oy Duodecim

Kertymät

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143. Kustannus Oy Duodecim

Keuhko levyepiteelikarsinooma

Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 550-551. Kustannus Oy Duodecim

Keuhkojen sytologiset näytteet

Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 557-558. Kustannus Oy Duodecim

Keuhkon adenokarsinooma

Lappi-Blanco Elisa, Mäkinen Johanna, Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 551-553. Kustannus Oy Duodecim

Keuhkon metastaattiset kasvaimet

Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 557. Kustannus Oy Duodecim

Keuhkon pienisoluinen karsinooma

Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 553-555. Kustannus Oy Duodecim

Keuhkon suurisoluinen karsinooma

Pirinen Risto, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 555-556. Kustannus Oy Duodecim

Keukokasvaimet

Pirinen Risto, Lappi-Blanco Elisa, Mäkinen Johanna, Kosma Veli-Matti & Pääkkö Paavo. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 547-550. Kustannus Oy Duodecim

Koagulaationekroosi

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 141-142. Kustannus Oy Duodecim

Kurkunpään kasvaimet

Hirvikoski Pasi & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 600-601. Kustannus Oy Duodecim

Kurkunpään rakenne, kehityshäiriöt ja tulehdukset

Hirvikoski Pasi & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 599-600. Kustannus Oy Duodecim

Lämpötilaan liittyvät vauriot soluissa

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 126. Kustannus Oy Duodecim

Mekaaninen vaurio, vierasaineet ja syövyttävät aineet

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 126-127. Duodecim

Nekroosi

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 141. Kustannus Oy Duodecim

Nestemäinen nekroosi

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 142. Kustannus Oy Duodecim

Oksidatiivinen stressi

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 119. Kustannus Oy Duodecim

PREDICT Plus: Development and validation of a prognostic model for early breast cancer that includes HER2

Wishart GC, Bajdik CD, Dicks E, Provenzano E, Schmidt MK, Sherman M, Greenberg DC,. Green AR, Gelmon KA, Kosma V-M, Olson JE, Beckmann MW, Winqvist R, Cross SS, Severi G, Huntsman D, Pylkäs K, Ellis I, Nielsen TO, Giles G, et.al.. 2012. British journal of cancer. 107: 800-807

Palautumaton soluvaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 137. Kustannus Oy Duodecim

Palautuva soluvaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 136-137. Kustannus Oy Duodecim

Patologia

Mäkinen M, Carpén O, Kosma V-M, Lehto V-P, Paavonen T & Stenbäck F. 2012. . . Kustannus Oy Duodecim

Perinnölliset lysosomaaliset kertymäsairaudet

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 147. Kustannus Oy Duodecim

Pigmenttikertymät

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 145-147. Kustannus Oy Duodecim

Proteiinikertymät

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 144-145. Kustannus Oy Duodecim

Proteini G:n epänormaali aktiivisuus

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 135-136. Kustannus Oy Duodecim

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Molecular and cellular endocrinology. 2013; 365: 270-276

Pulmonary inflammation and tissue damage in the mouse lung after exposure to PM samples from biomass heating appliances of old and modern technologies

Happo MS, Uski O, Jalava PI, Kelz J, Brunner T, Hakulinen P, Mäki-Paakkanen J, Kosma VM, Jokiniemi J, Obernberger I, Hirvonen M-R. 2012. Science of the total environment. 443: 256-266

Rasva- ja kolesterolikertymät

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143-144. Kustannus Oy Duodecim

Rasvanekroosi

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 143. Kustannus Oy Duodecim

Reperfuusiovaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 133. Kustannus Oy Duodecim

Reseptorivälitteinen toksisuus

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 129. Duodecim

SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?

Tengström M, Mannermaa A, Kosma V-M, Hirvonen A, Kataja V. 2012. Bmc cancer. 12: 257

Sikiölle toksiset aineet

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 127-129. Duodecim

Solumetabolia ja soluvaurio

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 117. Kustannus Oy Duodecim

Soluvaurio ja nekroosi

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen M, Carpén O, Kosma V-M, Lehto V-P, Paavonen T, Stenbäck F (toim.)(toim.) , 2012. Patologia. s. 3-16. Kustannus Oy Duodecim

Soluvauriomekanismit

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 130-131. Kustannus Oy Duodecim

Soluvaurion morfologia

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 136. Kustannus Oy Duodecim

Sopeutuminen

Böhm Jan, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 106-114. Kustannus Oy Duodecim

Stressiproteiinit

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 119-112. Kustannus Oy Duodecim

Säteilyn soluvaikutukset

Vähäkangas Kirsi, Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo, Stenbäck Frej(toim.) , 2012. Patologia. s. 125-126. Kustannus Oy Duodecim

The role of genetic breast cancer susceptibility variants as prognostic factors

Fasching PA, Pharoah PD, Cox A, Nevanlinna H, Bojesen SE, Karn T, Broeks A, Van Leeuwen FE, Van't Veer LJ, Udo R, Dunning AM, Greco D, Aittomäki K, Blomqvist C, Shah M, Nordestgaard BG, Flyger H, Hopper JL, Southey MC, Apicella C, et.al.. 2012. Human molecular genetics. 21: 3926-3939

Vapaiden radikaalien aiheuttama soluvaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 133-134. Kustannus Oy Duodecim

Virusten aiheuttama soluvaurio

Naukkarinen Anita & Kosma Veli-Matti. Teoksessa: Mäkinen Markus, Carpén Olli, Kosma Veli-Matti, Lehto Veli-Pekka, Paavonen Timo & Stenbäck Frej(toim.) , 2012. Patologia. s. 135. Kustannus Oy Duodecim

7q21-rs6964587 and breast cancer risk: an extended case¿control study by the Breast Cancer Association Consortium

Milne Roger L, Lorenzo-Bermejo Justo, Burwinkel Barbara, Malats Nuria, Arias Jose Ignasio, Zamora Pilar M, Benitéz Javier, humphreys Manjeet K, Garciá-Closas Montserrat, Chanock Stephen J, Lissowska Jolanta, Sherman Mark E, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Nevanlinna Heli, Heikkinen Tuomas, Aittomäki Kristiina Blomqvist Carl, Anto-Culver Hoda, et al.. 2011. Journal of medical genetics. 48: 698-702

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC, Wang X, Ademuyiwa F, Ahmed S, Ambrosone CB, Baglietto L, Balleine R, Bandera EV, Beckmann MW, Berg CD, Bernstein L, Blomqvist C, Blot WJ, Brauch H, Buring JE, Carey LA, Carpenter JE, Chang-Claude J, Chanock SJ, Chasman DI, Clarke CL, Cox A, Cross SS, Deming SL, Diasio RB, Dimopoulos AM, Driver WR, Dünnebier T, Durcan L, Eccles D, Edlund CK, Ekici AB, Fasching PA, Feigelson HS, Flesch-Janys D, Fostira F, Försti A, Fountzilas G, Ger. 2011. Nature genetics. 43: 1210-1214

Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

Yang Xiaohong R, Chang-Claude Jenny, Goode Ellen L, Couch Fergus J, Nevanlinna Heli, Milne Roger L, Gaudet Mia, Schmidt Marjanka K, Broeks Annegien, Cox Angela, Fasching Peter A, Hein Rebecca, Spurdle Amanda B, Blows Fiona, Driver Kristy, Flesch-Janys Dieter, Heinz Judith, Sinn Peter, Vrieling Alina, Heikkinen Tuomas et al. 2011. Journal of the national cancer institute. 103: 250-263

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.

Figueroa JD, Garcia-Closas M, Humphreys M, Platte R, Hopper JL, Southey MC, Apicella C, Hammet F, Schmidt MK, Broeks A, Tollenaar RA, Van't Veer LJ, Fasching PA, Beckmann MW, Ekici AB, Strick R, Peto J, Dos Santos Silva I, Fletcher O, Johnson N, Sawyer E, Tomlinson I, Kerin M, Burwinkel B, Marme F, Schneeweiss A, Sohn C, Bojesen S, Flyger H, Nordestgaard BG, Benítez J, Milne RL, Ignacio Arias J, Zamora MP, Brenner H, Müller H, Arndt V, Rahman N, Turnbull C, Seal S, Renwick A, Brauch H, Justenhov. 2011. Human molecular genetics. 20: 4693-4706

Common breast cancer susceptibility loci are associated with triple-negative breast cancer.

Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C, Fasching PA, Miron P, Eccles D, Carpenter JE, Godwin AK, Ambrosone C, Winqvist R, Brauch H; GENICA consortium, Schmidt MK, Cox A, Cross SS, Sawyer E, Hartmann A, Beckmann MW, Schulz-Wendtland R, Ekici AB, Tapper WJ, Gerty SM, Durcan L, Graham N, Hein R, Nickels S, Flesch-Janys D, Heinz J, Sinn HP, Konstantopoulou I, Fostira F, Pectasides D, Dimopoulos AM, Fountzilas G, Clarke CL, Balleine R, Olson JE, Fredericksen Z, Diasio RB, Patha. 2011. Cancer research. 71: 6240-6249

Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer.

Milne RL, Goode EL, García-Closas M, Couch FJ, Severi G, Hein R, Fredericksen Z, Malats N, Zamora MP, Pérez JI, Benítez J, Dörk T, Schürmann P, Karstens JH, Hillemanns P, Cox A, Brock IW, Elliot G, Cross SS, Seal S, Turnbull C, Renwick A, Rahman N, Shen CY, Yu JC, Huang CS, Hou MF, Nordestgaard BG, Bojesen SE, Lanng C, Alnæs GG, Kristensen V, Børrensen-Dale AL, Hopper JL, Dite GS, Apicella C, Southey MC, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Sangrajrang S, Gaborieau V, Brennan P, McKay. 2011. Cancer epidemiology biomarkers and prevention. 20: 2222-2231

Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.

Stevens KN, Garcia-Closas M, Fredericksen Z, Kosel M, Pankratz VS, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Tollenaar RA, Fasching PA, Beckmann MW, Hein A, Ekici AB, Johnson N, Peto J, Dos Santos Silva I, Gibson L, Sawyer E, Tomlinson I, Kerin MJ, Chanock S, Lissowska J, Hunter DJ, Hoover RN, Thomas GD, Milne RL, Pérez JA, González-Neira A, Benítez J, Burwinkel B, Meindl A, Schmutzler RK, Bartrar CR, Hamann U, Ko YD, Brüning T, Chang-Claude J, Hein R, Wan. 2011. British journal of cancer. 105: 1934-9

Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.

Vuorela M, Pylkäs K, Hartikainen JM, Sundfeldt K, Lindblom A, von Wachenfeldt Wäppling A, Haanpää M, Puistola U, Rosengren A, Anttila M, Kosma VM, Mannermaa A, Winqvist R.. 2011. Breast cancer research and treatment. 130: 1003-10

Hyaluronan in human malignancies

Sironen RK, Tammi M, Tammi R, Auvinen PK, Anttila M & Kosma VM. 2011. Experimental cell research. 317: 383-391

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

Broeks, Annegien; Schmidt, Marjanka K; Sherman, Mark E; Couch, Fergus J; Hopper, John L; Dite, Gillian S; Apicella, Carmen; Smith, Letitia D; Hammet, Fleur; Southey, Melissa C; Van't Veer, Laura J; de Groot, Renate; Smit, Vincent T. H. B. M; Fasching, Peter A; Beckmann, Matthias W; Jud, Sebastian; Ekici, Arif B; Hartmann, Arndt; Hein, Alexander; Schulz-Wendtland, Ruediger et al.. 2011. Human molecular genetics. 20: 3289-3303

Nanosized TiO2 caused minor airflow limitation in the murine airways

Leppänen Maija, Korpi Anne, Miettinen Mirella, Leskinen Jani, Torvela Tiina, Rossi Elina, Vanhala Esa, Wolff Henrik, Alenius Harri, Kosma Veli-Matti, Joutsensaari Jorma, Jokiniemi Jorma, Pasanen Pertti. 2011. Archives of toxicology. 85: 827-839

Transcription factors zeb1, twist and snai1 in breast carcinoma

Soini Ylermi, Tuhkanen Hanna, Sironen Reijo, Virtanen Ismo, Kataja Vesa, Auvinen Päivi, Mannermaa Arto, Kosma Veli-Matti. 2011. Bmc cancer. 11: -

Transcription of factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma

Jouppila-Mättö A, Tuhkanen H, Soini Y, Pukkila M, Närkiö-Mäkelä M, Sironen R, Virtanen I, Mannermaa A, Kosma V-M. 2011. Histology and histopathology. 26: 443-449

Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression

Juoppila-Mättö Anna, Närkiö-Mäkelä Mervi, Soini Ylermi, Pukkila Matti, Sironen Reijo, Tuhkanen Hanna, Mannermaa Arto, Kosma Veli-Matti. 2011. Bmc cancer. 11: 350

VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2

Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2011. Cancer gene therapy. 18: 100-9

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the Breast Cancer Association Consortium: a combined case-controt study

Milne RL, Gaudet MM, Spurdle AB, Fasching PA, Couch FJ & et al. 2010. Breast cancer research. 12: 110

Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival

Azzato EM, Tyrer J, Fasching PA, Beckmann MW, Ekici AB, Schulz-Wendtland R, Bojesen SE, Nordestgaard BG, Flyger H, Milne RL, et.al.. 2010. Journal of the national cancer institute. 102: 650-662

Churg-Strauss syndrome manifested by appendicitis, cholecystitis and superficial micronodular liver lesions-an unusual clinicopathological presentation

Sironen RK, Seppä A, Kosma VM. 2010. Journal of clinical pathology. 63: 848-850

Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice

Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. 2010. Cancer gene therapy. 18: 100-109

Downregulated CD44 and hyaluronan expression in vulvar intraepithelial neoplasia and squamous cell carcinomas

Hämäläinen K, Kosma V-M, Eloranta M-L, Tammi R, Tammi M, Leppänen M, Heinonen S & Anttila M. 2010. Acta obstetricia et gynecologica scandinavica. 89: 108-119

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

Nykopp TK, Rilla K, Tammi MI, Tammi RH, Sironen R, Hämäläinen K, Kosma V-M, Heinonen S & Anttila M. 2010. Bmc cancer. 10: 512

Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities

Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Dormans JAMA, Gerlofs-Nijland ME, Cassee FR, Kosma V-M, Sillanpää M, Hillamo R & Hirvonen M-R. 2010. Inhalation toxicology. 22: 402-416

Missense Variants in ATM in 26,101 Breast Cancer Cases and 29,842 Controls

Fletcher O, Johnson N, Dos Santos Silva I, Orr N, Ashworth A, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Burwinkel B, et.al.. 2010. Cancer epidemiology biomarkers and prevention. 19: 2143-2151

Nutrient intakes during diets including unkilned and large amounts of oats in celiac disease

Kemppainen TA, Heikkinen MT, Ristikankare MK, Kosma VM, Julkunen RJ. 2010. European journal of clinical nutrition. 64: 62-67

Preoperative angiopoietin-2 serum levels. A marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer

Sallinen H, Heikura T, Laidinen S, Kosma V-M, Heinonen S, Ylä-Herttuala S & Anttila M. 2010. International journal of gynecological cancer. 20: 1498-1505

Prognostic impact of CD31-positive microvessel density in follicular lymphoma patients treated with immunochemotherapy

Taskinen Minna, Jantunen Esa, Kosma Veli-Matti, Bono Petri, Karjalainen-Lindsberg Marja-Liisa, Leppä Sirpa. 2010. European journal of cancer. 46: 2506-2512

ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival

Kauppinen J, Kosma V-M, Soini Y, Sironen R, Nissinen M, Nykopp T, Kärjä V, Eskelinen M, Kataja V, Mannermaa A. 2010. Cancer epidemiology biomarkers and prevention. 19: 2133-2142

Antiangiogenic gene therapy with soluble VEGFR-1, -2 and -3 reduces the growth of solid human ovarian carcinoma in mice

Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma V-M, Heinonen S, Alitalo K, Yla-Herttuala S. 2009. Molecular therapy. 17: 278-284

Association of ESR1 gene tagging SNPs with breast cancer risk

Dunning AM, Healey CS, Baynes C, Maia A-T, Scollen S, Vega A, Rodrígues R, Barbosa-Morais N L, Ponder BAJ..., Mannermaa A, Kosma V-M, ...Pooley KA, Chenevix-Trench G. 2009. Human molecular genetics. 18: 1131-1139

Depletion of cell surface CD44 in nonmelanoma skin tumors is associated with increased expression of matrix metalloproteinase 7

Hartmann-Petersen S, Tammi RH, Tammi MI, Kosma V-M. 2009. British journal of dermatology. 160: 1251-1257

Effect of unkilned and large amounts of oats on nutritional state of celiac patients in remission

Kemppainen T, Heikkinen M, Ristikankare M, Kosma V-M, Julkunen R. 2009. E-SPEN, THE EUROPEAN E-JOURNAL OF CLINICAL NUTRITION AND METABOLISM. 4: e30-e40

Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content

Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M. 2009. Bmc cancer. 9: [9 p.]

Five polymorphisms and breast cancer risk: results from the breast cancer association consortium

Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL..., Mannermaa A, Kataja V, Kosma V-M, Lindblom SM...et al. 2009. Cancer epidemiology biomarkers and prevention. 18: 1610-1616

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Mannermaa A, Kosma V-M, Kataja V, ...Easton DF. 2009. Nature genetics

Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression

Tuhkanen H, Soini Y, Kosma V-M, Anttila M, Sironen R, Hämäläinen K, Kukkonen L, Virtanen I, Mannermaa A. 2009. Bmc cancer. 9:

Reduced gamma-catenin expression and poor survival in oral squamous cell carcinoma

Närkiö-Mäkelä M, Pukkila M, Lagerstedt E, Virtaniemi J, Pirinen R, Johansson R, Kosunen A, Lappalainen K, Hämäläinen K, Kosma V-M. 2009. Archives of otolaryngology : head and neck surgery. 135: 1035-1040

Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042

Milne RL, Benítez J, Nevanlinna H, Heikkinen T..., Mannermaa A, Kataja V, Kosma V-M. 2009. Journal of the national cancer institute. 101: 1012-1018

Ruumiinavaukset opettavat yhä. Onko lääketieteellisten ruumiinavauksien väheneminen ongelma?

Kosma Veli-Matti. 2009. Duodecim

Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome

Bergamaschi A, Tagliabue E, Sorlie T, Naume B, Triulzi T, Orlandi R, Russnes HG, Nesland JM, Tammi R, Auvinen P, Kosma V-M, Ménard S, Borresen-Dale A-L. 2008. Journal of pathology. 214: 357-367

Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics

Garcia-Closas M, Hall P, Nevanlinna H ..., Mannermaa A, Uusitupa M, Eskelinen M, Tengström M, Kosma V-M, Kataja V, Chenevix-Trench G .... 2008. PLoS genetics. 4: [e1000054]

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

Tammi RH, Kultti A, Kosma V-M, Pirinen R, Auvinen P, Tammi MI. 2008. Seminars in cancer biology. 18: 288-295

Impact of germinal center and non-germinal center phenotypes on overall and failure-free survival after high-dose chemotherapy and auto-SCT in primary diffuse large B-cell lymphoma

Nyman H, Jantunen E, Juvonen E, Elonen E, Böhm J, Kosma V-M, Enblad G, Karjalainen-Lindsberg M-L, Leppä S. 2008. Bone marrow transplantation. 42: 93-98

Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumor recurrence and unfavourable outcome in non-small cell lung cancer

Leinonen T, Pirinen R, Böhm J, Johansson R, Kosma V-M. 2008. Histology and histopathology. 23: 693-700

NAD(P)H:quinone oxidoreductase 1 NQ01*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

Fagerholm Rainer, Hofstetter Barbara, Tommiska Johanna, Aaltonen Kirsimari, Vrtel Radek, Syrjäkoski Kirsi, Kallioniemi Anne, Kilpivaara Outi, Mannermaa Arto, Kosma Veli-Matti, Uusitupa Matti, Eskelinen Matti, Kataja Vesa, Aittomäki Kristiina. 2008. Nature genetics. 40: 844-853

Penetrance analysis of the PALB2 c.1592delT founder mutation

Erkko H, Dowty JG, Nikkilä J, Syrjäkoski K, Mannermaa A, Pylkäs K, Southey MC, Holli K, Kallioniemi A, Jukkola-Vuorinen A, Kataja Vesa, Kosma V-M, Xia B, Livingston DM, Wingvist R, Hopper JL. 2008. Clinical cancer research. 14: 4667-4671

Two distinct local relapse subtypes in invasive breast cancer: effect on their prognostic impact

Casalini P, Carcangiu ML, Tammi R, Auvinen P, Kosma V-M, Valagussa P, Greco M, Balsari A, Ménard S, Tagliabue E. 2008. Clinical cancer research. 14: 25-31

Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study

Kemppainen TA, Heikkinen MT, Ristikankare MK, Kosma V-M, Sontag-Strohm TS, Brinck O, Salovaara HO, Julkunen RJ. 2008. Scandinavian journal of gastroenterology. 43: 1094-1101

WNT-4 mRNA expression in human adrenocortical tumors and cultured adrenal cells

Kuulasmaa T, Jääskeläinen J, Suppola S, Pietiläinen T, Heikkilä P, Aaltomaa S, Kosma V-M, Voutilainen R. 2008. Hormone and metabolic research. 40: 668-673

A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course

Hartikainen JM, Mannermaa A, Heinonen S, Kosma V-M, Kataja V. 2007. Anticancer research. 27: 4295-4300

A common coding variant in CASP8 is associated with breast cancer risk

Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MWR, Pooley KA..., Mannermaa A, Hartikainen J, Kataja V, Kosma V-M, ... Couch FJ .... 2007. Nature genetics. 39: 352-358

A recurrent mutation in PALB2 in Finnish cancer families

Erkko Hannele, Bing Xia, Nikkilä Jenni, Schleutker Johanna, Syrjäkoski Kirsi, Mannermaa Arto, Kallioniemi Anne, Pylkäs Katri, Karppinen Sanna-Maria, Rapakko Katrin, Alexander Miron, Qing Sheng, Guilan Li, Mattila Henna, Daphene W. Bell. 2007. Nature

Activator protein-2 in carcinogenesis with a special reference to breast cancer-A mini review

Pellikainen JM, Kosma V-M. 2007. International journal of cancer. 120: 2061-2067

Biological and prognostic role of acid cysteine proteinase inhibitor (ACPI, cystatin A) in non-small-cell lung cancer

Leinonen T, Pirinen R, Böhm J, Johansson R, Rinne A, Weiber E, Kosma V-M. 2007. Journal of clinical pathology. 60: 515-519

CD44 expression and its relationship with MMP-9, clinicopathological factors and survival in oral squamous cell carcinoma

Kosunen A, Pirinen R, Ropponen K, Pukkila M, Kellokoski J, Virtaniemi J, Sironen R, Juhola M, Kumpulainen E, Johansson R, Nuutinen J, Kosma V-M. 2007. Oral oncology. 43: 51-59

CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish caucasian population

Sillanpää P, Heikinheimo L, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Metsola K, Hirvonen A. 2007. Breast cancer research and treatment. 104: 287-297

DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification

Nowee ME, Snijders AM, Rockx DAP, de WIT RM, Kosma VM, Hämäläinen K, Schouten JP, Verheijen RHM, van Diest PJ, Albertson DG, Dorsman JC. 2007. Journal of pathology. 213: 46-55

Dose and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine, and ultrafine particles from six European cities

Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Kosma VM, Sillanpää M, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen M-R. 2007. Inhalation toxicology. : 227-246

Dose- and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine and ultrafine particles from six European cities

Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Kosma VM, Sillanpää M, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen M-R.. 2007. Inhalation toxicology. 19: 227-246

Genome-wide association study identifies novel breast cancer susceptibility loci

Easton DF, Pooley KA, Dunning AM..., Mannermaa A, Kosma V-M, Kataja V, Hartikainen J. 2007. Nature. 447: 1087-1093

HER-2/neu and p27Kip1 in progression of fallopian tube carsinoma: an immunohistochemical and array comparative genomic hybridization study

Nowee ME, Dorsman JC, Piek JMJ, Kosma VM, Hämäläinen K, Verheijen RHM, van Diest PJ. 2007. Histopathology. 51: 666-673

High stromal versican expression predicts unfavourable outcome in oral squamous cell carcinoma

Pukkila M, Kosunen A, Ropponen K, Virtaniemi J, Kellokoski J, Kumpulainen E, Pirinen R, Nuutinen J, Johansson R, Kosma V-M. 2007. Journal of clinical pathology. 60: 267-272

Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation

Karihtala P, Soini Y, Auvinen P, Tammi R, Tammi M, Kosma V-M. 2007. Journal of histochemistry and cytochemistry. 55: 1191-1198

No observed local immunological response at cell level after five years of oats in adult coeliac disease

Kemppainen T, Janatuinen E, Holm K, Kosma V-M, Heikkinen M, Mäki M, Laurila K, Uusitupa M, Julkunen R. 2007. Scandinavian journal of gastroenterology. 42: 54-59

Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer

Sillanpää S, Anttila M, Suhonen K, Hämäläinen K, Turpeenniemi-Hujanen T, Puistola U, Tammi M, Sironen R, Saarikoski S, Kosma VM. 2007. Tumor biology. 28: 280-289

Prognostic significance of iNOS in epithelial ovarian cancer

Anttila MA, Voutilainen K, Merivalo S, Saarikoski S, Kosma V-M. 2007. Gynecologic oncology. 105: 97-103

Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer

Sillanpää S, Anttila M, Voutilainen K, Ropponen K, Turpeenniemi-Hujanen T, Puistola U, Tammi R, Tammi M, Sironen R, Saarikoski S, Kosma V-M. 2007. Gynecologic oncology. 104: 296-303

Quantification of angiogenesis by the Chalkley method and its prognostic significance in epithelial ovarian cancer

Suhonen KA, Anttila MA, Sillanpää SM, Hämäläinen KM, Saarikoski SV, Juhola M, Kosma V-M. 2007. European journal of cancer. 43: 1300-1307

Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families

Hartikainen JM, Kataja V, Pirskanen M, Arffman A, Ristomaa U, Vahteristo P, Ryynänen M, Heinonen S, Kosma V-M, Mannermaa A. 2007. Clinical genetics. 72: 311-320

A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up

Sallinen H, Anttila M, Narvainen J, Ordén M-R, Ropponen K, Kosma V-M, Heinonen S, Yla-Herttuala S. 2006. Gynecologic oncology. 103: 315-320

Commonly studied single-nucleotide polymorphism and breast cancer: results from the breast cancer association consortium

The Breast Cancer Association Consortium, Mannermaa A, Kataja V, Kosma V-M. 2006. Journal of the national cancer institute. 98: 1382-1396

Expression of matrix metalloproteinases 7 and 9 in non-smal cell lung cancer relation to clinicopathological factors,ß-catenin and prognosis

Leinonen T, Pirinen R, Böhm J, Johansson R, Ropponen K, Kosma V-M. 2006. Lung cancer. 51: 313-321

Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas

Tuhkanen H, Anttila M, Kosma V-M, Heinonen S, Juhola M, Helisalmi S, Kataja V, Mannermaa A, Helisalmi S. 2006. International journal of cancer. 119: 1345-1353

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 191-199

HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 1299-1304

Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer

Voutilainen KA, Anttila MA, Sillanpää SM, Ropponen KM, Saarikoski SV, Juhola MT, Kosma V-M. 2006. Journal of clinical pathology. 59: 460-467

Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression

Sillanpää SM, Anttila MA, Voutilainen KA, Ropponen KM, Sironen RK, Saarikoski SV, Kosma V-M. 2006. International journal of cancer. 119: 1792-1799

Refinement of the 22q12-q13 Breast Cancer-Associated Region:Evidence of TMPRSS6 as a Candidate in an Eastern Finnish Population

Hartikainen JM, Tuhkanen H, Kataja V, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A. 2006. Clinical cancer research. 12: 1454-1462

An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in Eastern Finland: three candidate regions found

Hartikainen JM, Tuhkanen H, Kataja V, Dunning AM, Antoniou A, Smith P, Arffman A, Pirskanen M, Easton DF, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A. 2005. Cancer epidemiology biomarkers and prevention. 14: 75-80

Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study

Kuusisto J, Räsänen K, Särkioja T, Alarakkola E, Kosma V-M. 2005. Heart. 91: 576-582

Elevated expression of hyaluronan and its CD44 receptor in the duodenall mucosa of coeliac patients

Kemppainen T, Tammi R, Tammi M, Ågren U, Julkunen R, Böhm J, Uusitupa M, Kosma V-M. 2005. Histopathology. 46: 64-72

Expression of CD44s, CD44v3 and CD44v6 in benign and malignant breast lesions:correlation and colocalization with hyaluronan

Auvinen P, Tammi R, Tammi M, Johansson R, Kosma V-M. 2005. Histopathology. 47: 420-428

Mitä uutta rintasyövän biologiasta ja ennustetekijöistä?

Kosma V-M. 2005. Duodecim

NAT2 slow acetylator genotype as an important modifier of breast cancer risk

Sillanpää P, Hirvonen A, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Mitrunen K. 2005. International journal of cancer. 114: 579-584

Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women

Sillanpää P, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Mitrunen K, Hirvonen A. 2005. Pharmacogenetics and genomics. 15: 749-752

Versican in nonsmall cell lung cancer: relation to hyaluronan, clinicopathologic factors, and prognosis

Pirinen R, Leinonen T, Böhm J, Johansson R, Ropponen K, Kumpulainen E, Kosma V-M. 2005. Human pathology. 36: 44-50

XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in the Finnish case-control study

Metsola K, Kataja V, Sillanpää P, Siivola P, Heikinheimo L, Eskelinen M, Kosma V-M, Uusitupa M, Hirvonen A. 2005. Breast cancer research. 7: R987-R997

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies

The CHEK2 Breast Cancer Case-Control Consortium, Kataja V. 2004. American journal of human genetics. 74: 1175-1182

Expression of HER2 and its association with AP-2 in breast cancer

Pellikainen J, Naukkarinen A, Ropponen K, Rummukainen J, Kataja V, Kellokoski J, Eskelinen M, Kosma V-M. 2004. European journal of cancer. 40: 1485-1495

Expression of extracellular matrix components versican, chondroitin sulfate, tenascin, and hyaluronan, and their association with disease outcome in node-negative breast cancer

Suwiwat S, Ricciardelli C, Tammi R, Tammi M, Auvinen P, Kosma V-M, LeBaron RG, Raymond WA, Tilley WD, Horsfall DJ. 2004. Clinical cancer research. 10: 2491-2498

Expression of matrix metalloproteinase (MMP)-2 and MMP-2 in breast cancer with a special reference to activator protein-2, HER2, and prognosis

Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma V-M. 2004. Clinical cancer research. 10: 7621-7628

Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p

Tuhkanen H, Anttila M, Kosma V-M, Ylä-Herttuala S, Heinonen S, Kuronen A, Juhola M, Tammi R, Tammi M, Mannermaa A. 2004. International journal of cancer. 109: 247-252

Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci

Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. 2004. American journal of medical genetics. Part A. 130: 345-350

Marked allelic imbalance on chromosome 5q31 does not explain a-catenin expression in epithelial ovarian cancer

Tuhkanen H, Anttila M, Kosma V-M, Puolakka J, Juhola M, Heinonen S, Mannermaa A. 2004. Gynecologic oncology. 94: 416-421

Morphometric analysis of the small intestine in wild type mice C57BL/6J - a developmental study

Gulbinowicz M, Berdel B, Wójcik S, Dziewiatkowski J, Oikarinen S, Mutanen M, Kosma V-M, Mykkänen H, Morys¿ J. 2004. Folia morphologica. 63: 423-430

Obstetric prognosis after placental abruption

Toivonen S, Heinonen S, Anttila M, Kosma V-M, Saarikoski S. 2004. Fetal diagnosis and therapy. 19: 336-341

Reduced expression of hyaluronan is a strong indicator of poor survival in oral squamous cell carcinoma

Kosunen A, Ropponen K, Kellokoski J, Pukkila M, Virtaniemi J, Valtonen H, Kumpulainen E, Johansson R, Tammi R, Tammi M, Nuutinen J, Kosma V-M. 2004. Oral oncology. 40: 257-263

The expression and prognostic value of alfa-, beeta- and gamma-catenins in renal cell carcinoma

Aaltomaa S, Lipponen P, Kärjä V, Lundstedt S, Lappi J, Kosma V-M. 2004. Anticancer research. 24: 2407-2414

Versican expression in pharyngeal squamous cell carcinoma: an immunohistochemical study

Pukkila MJ, Kosunen AST, Virtaniemi JA, Kumpulainen EJ, Johansson RT, Kellokoski JK, Nuutinen J, Kosma V-M. 2004. Journal of clinical pathology. 57: 735-739

Vitamin D receptor gene polymorphism as an important modifier of positive family history related breast cancer risk

Sillanpää P, Hirvonen A, Kataja V, Eskelinen M, Kosma V-M, Uusitupa M, Vainio H, Mitrunen K. 2004. Pharmacogenetics and genomics. 14: 239-245

Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo

Hiltunen MO, Ruuskanen M, Huuskonen J, Mähönen AJ, Ahonen M, Rutanen J, Kosma V-M, Mahonen A, Kröger H, Ylä-Herttuala S. 2003. Faseb journal. 17: 1147-1149

Alpha-, beta- and chi-catenin expression in human pancreatic cancer

Julkunen K, Mäkinen K, Kärjä V, Kosma V-M, Eskelinen M. 2003. Anticancer research. 23: 5043-5048

CD44 expression indicates favorable prognosis in epithelial ovarian cancer

Sillanpää S, Anttila MA, Voutilainen K, Tammi RH, Tammi MI, Saarikoski SV, Kosma V-M. 2003. Clinical cancer research. 9: 5318-5318

Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice

Heikkinen P, Kosma V-M, Alhonen L, Huuskonen H, Komulainen H, Kumlin T, Laitinen JT, Lang S, Puranen L, Juutilainen J. 2003. International journal of radiation biology. 79: 221-233

Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells

Liu J, Kuulasmaa T, Kosma V-M, Bützow R, Vänttinen T, Hydén-Granskog C, Voutilainen R. 2003. Journal of clinical endocrinology and metabolism. 88: 5002-5008

Hyaluronan, CD44 and versican in epidermal keratinocyte tumours

Karvinen S, Kosma V-M, Tammi MI, Tammi R. 2003. British journal of dermatology. 148: 86-94

Myometrial inflammation in human delivery and its association with labor and infection

Keski-Nisula LT, Aalto M-L, Kirkinen PP, Kosma V-M, Heinonen ST. 2003. American journal of clinical pathology. 120: 217-224

Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic beta-catenin in min mice

Pajari A-M, Rajakangas J, Päivärinta E, Kosma V-M, Rafter J, Mutanen M. 2003. International journal of cancer. 106: 653-660

Slight respiratory irritation but not inflammation in mice exposed to (1-3)-beta-D-glucan aerosols

Korpi A, Kasanen J-P, Kosma V-M, Rylander R, Pasanen A-L. 2003. Mediators of inflammation. 12: 139-146

Systemic immunoresponses in mice after repeated exposure of lungs to spores of Streptomyces californicus

Jussila J, Pelkonen J, Kosma V-M, Mäki-Paakkanen J, Komulainen H, Hirvonen M-R. 2003. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY. 10: 30-37

The effect of photodynamic therapy on rat urinary bladder with orthotopic urothelial carcinoma

Grönlund-Pakkanen S, Wahlfors J, Talja M, Kosma V-M, Pakkanen TM, Ala-Opas M, Alhava E, Moore RB. 2003. BJU international. 92: 125-130

Versican in epithelial ovarian cancer: relation to hyaluronan, clinicopathologic factors and prognosis

Voutilainen K, Anttila M, Sillanpää S, Tammi R, Tammi M, Saarikoski S, Kosma V-M. 2003. International journal of cancer. 107: 359-364

p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis

Pellikainen MJ, Pekola TT, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma V-M. 2003. Journal of clinical pathology. 56: 214-220

Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model

Tyynelä K, Sandmair A-M, Turunen M, Vanninen R, Vainio P, Kauppinen R, Johansson R, Vapalahti M, Ylä-Herttuala S. 2002. Cancer gene therapy. 9: 917-924

Combined COMT and GST genotypes and hormone replacement therapy associated breast cancer risk

Mitrunen K, Kataja V, Eskelinen M, Kosma V-M, Kang D, Benhamou S, Vainio H, Uusitupa M, Hirvonen A. 2002. Pharmacogenetics and genomics. 12: 67-72

Effects of aerosols from nontoxic Stachybotrys chartarum on murine airways

Korpi A, Kasanen J-P, Raunio P, Kosma V-M, Virtanen T, Pasanen A-L. 2002. Inhalation toxicology. 14: 521-540

Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors

Hiltunen ELJ, Anttila M, Kultti A, Ropponen K, Penttinen J, Yliskoski M, Kuronen AT, Juhola M, Tammi R, Tammi M, Kosma V-M. 2002. Cancer research. 62: 6410-6413

Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)

Hakulinen P, Kosma V-M, Komulainen H. 2002. Anticancer research. 22: 703-706

Gonadotrophins inhibit the expression of insulin-like growth factor binding protein-related protein-2 mRNA in cultured human granulosa-luteal cells

Liu J, Kosma V-M, Vänttinen T, Hyden-Granskog C, Voutilainen R. 2002. Molecular human reproduction. 8: 136-141

Haimasyöpä

Hietanen T, Johansson R, Joensuu H. Teoksessa: Joensuu H, Kouri M, Ojala M, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 221-229. Duodecim

Hyaluronan expression in differentiated thyroid carcinoma

Böhm J, Niskanen L, Tammi R, Tammi M, Eskelinen M, Pirinen R, Hollmen S, Alhava E, Kosma V-M. 2002. Journal of pathology. 196: 180-185

Hyvänlaatuiset sairaudet

Salminen E, Hakala T, Johansson R, Mäntylä M. Teoksessa: Joensuu H, Kouri M, Ojala A, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 368-374. Duodecim

Ihomelanooma

Johansson R, Pyrhönen S, Mäntylä M. Teoksessa: Joensuu H, Kouri M, Ojala A, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 346-349. Duodecim

Ihon levyepiteeli- ja tyvisolusyöpä

Johansson R, Pyrhönen S, Mäntylä M. Teoksessa: Joensuu H, Kouri M, Ojala A, Tenhunen M, Lyly T(toim.) , 2002. Kliininen sädehoito. s. 350-353. Duodecim

Inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: Relation to p53 expression, clinicopathological data, and survival

Pukkila MJ, Kellokoski JK, Virtaniemi JA, Kumpulainen EJ, Johansson RT, Halonen PM, Kosunen AST, Nuutinen J, Kosma V-M. 2002. Laryngoscope. 112: 1084-1088

Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs

Jussila J, Komulainen H, Kosma V-M, Pelkonen J, Hirvonen M-R. 2002. Environmental toxicology and pharmacology. 12: 137-145

Murine respiratory and immunological responses to the inhaled aerosols of Stachybotrys chartarum extract

Korpi A, Kasanen J-P, Kosma V-M, Virtanen T, Pasanen A-L. 2002. ANNALS OF OCCUPATIONAL HYGIENE. SUPPLEMENT. 46: 272-276

Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs

Jussila J, Komulainen H, Huttunen K, Roponen M, Iivanainen E, Torkko P, Kosma V-M, Pelkonen J, Hirvonen M-R. 2002. Environmental health perspectives. 110: 1119-1125

No harm from five year ingestion of oats in coeliac disease

Janatuinen EK, Kemppainen TA, Julkunen RJK, Kosma V-M, Mäki M, Heikkinen M, Uusitupa MIJ. 2002. Gut. 50: 332-335

Nuclear and cytoplasmic p53 expression in pharyngeal squamous cell carcinoma: prognostic implications

Pukkila MJ, Kumpulainen EJ, Virtaniemi JA, Johansson RT, Halonen PM, Kellokoski JK, Kosunen AST, Nuutinen J, Kosma V-M. 2002. Head and neck: journal for the sciences and specialties of the head and neck. 24: 784-791

Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer

Pellikainen J, Kataja V, Ropponen K, Kellokoski J, Pietiläinen T, Böhm J, Eskelinen M, Kosma V-M. 2002. Clinical cancer research. 8: 3487-3495

Reproductive risk factors, doppler findings, and outcome of affected births in placental abruption: a population-based analysis

Toivonen S, Heinonen S, Anttila M, Kosma V-M, Saarikoski S. 2002. American journal of perinatology. 19: 451-459

Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs

Jussila J, Komulainen H, Kosma V-M, Nevalainen A, Pelkonen J, Hirvonen M-R. 2002. Inhalation toxicology. 14: 1261-1277

Strong stromal hyaluronan expression is associated with PSA recurrence in local prostate cancer

Aaltomaa S, Lipponen P, Tammi R, Tammi M, Viitanen J, Kankkunen J-P, Kosma V-M. 2002. Urologia internationalis. 69: 266-272

Supraglottic and glottic carcinomas: clinically and biologically distinct entities?

Hirvikoski P, Virtaniemi J, Kumpulainen E, Johansson R, Kosma V-M. 2002. European journal of cancer. 38: 1717-1723

p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields

Kumlin T, Heikkinen P, Kosma V-M, Alhonen L, Jänne J, Juutilainen J. 2002. Radiation and environmental biophysics. 41: 155-158

Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes

Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Gene therapy. 8: 784-788

Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk

Mitrunen K, Sillanpää P, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Uusitupa M, Hirvonen A. 2001. Carcinogenesis. 22: 827-829

Decline after immobilisation and recovery after remobilisation of synovial fluid il1, timp, and chondroitin sulphate levels in young beagle dogs

Haapala J, Arokoski JPA, Rönkkö S, Ågren U, Kosma V-M, Lohmander LS, Tammi M, Helminen HJ, Kiviranta I. 2001. Annals of the rheumatic diseases. 60: 55-60

Effects of 50 Hz magnetic fields on cancer induced by ionizing radiation in mice

Heikkinen P, Kosma V-M, Huuskonen H, Komulainen H, Kumlin T, Penttilä I, Väänänen A, Juutilainen J. 2001. International journal of radiation biology. 77: 483-495

Effects of mobile phone radiation on X-ray-induced tumorigenesis in mice

Heikkinen P, Kosma V-M, Hongisto T, Huuskonen H, Hyysalo P, Komulainen H, Kumlin T, Lahtinen T, Lang S, Puranen L, Juutilainen J. 2001. Radiation research. 156: 775-785

Expression and prognostic value of CD44 standard and variant v3 and v6 isoforms in prostate cancer

Aaltomaa S, Lipponen P, Ala-Opas M, Kosma V-M. 2001. European urology. 39: 138-144

Expression of CD44 and its variant isoform v3 has no prognostic value in gastric cancer

Setälä L, Lipponen P, Tammi R, Tammi M, Eskelinen M, Alhava E, Kosma V-M. 2001. Histopathology. 38: 13-20

Expression of transcription factor AP-2 in colorectal adenomas and adenocarcinomas: comparison of immunohistochemistry and in situ hybridisation

Ropponen KM, Kellokoski JK, Pirinen RT, Moisio KI, Eskelinen MJ, Alhava EM, Kosma V-M. 2001. Journal of clinical pathology. 54: 533-538

Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer

Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Vainio H, Uusitupa M, Hirvonen A. 2001. Cancer epidemiology biomarkers and prevention. 10: 229-236

High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer

Lipponen P, Aaltomaa S, Tammi R, Tammi M, Ågren U, Kosma V-M. 2001. European journal of cancer. 37: 849-856

Inducible nitric oxide synthase (iNOS) expression and its prognostic value in prostate cancer

Aaltomaa SH, Lipponen PK, Kosma V-M. 2001. Anticancer research. 21: 3101-3106

Inflammatory responses in mice after intratracheal instillation of spores of streptomyces californicus isolated from indoor air of a molby building

Jussila J, Komulainen H, Huttunen K, Roponen M, Hälinen A, Hyvärinen A, Kosma V-M, Pelkonen J, Hirvonen M-R. 2001. Toxicology and applied pharmacology. 171: 61-69

Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma

Pukkila MJ, Virtaniemi JA, Kumpulainen EJ, Pirinen RT, Johansson RT, Valtonen HJ, Juhola MT, Kosma V-M. 2001. Journal of clinical pathology. 54: 42-47

Polymorphic GSTs and cancer predisposition

Hirvonen A, Bouchardy C, Mitrunen K, Kataja V, Eskelinen M, Kosma V-M, Saarikoski ST, Jourenkova N, Anttila S, Dayer P, Uusitupa M, Benhamou S. 2001. Chemico-biological interactions. 133: 75-80

Polymorphic catechol-O-methyltransferase gene and breast cancer risik

Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Kang D, Vainio H, Uusitupa M, Hirvonen A. 2001. Cancer epidemiology biomarkers and prevention. 10: 635-640

Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarsinoma

Pirinen R, Tammi R, Tammi M, Hirvikoski P, Parkkinen JJ, Johansson R, Böhm J, Hollmén S, Kosma V-M. 2001. International journal of cancer. 95: 12-17

Reduced expression of alfa-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer

Pirinen RT, Hirvikoski P, Johansson RT, Hollmén S, Kosma V-M. 2001. Journal of clinical pathology. 54: 391-395

Surgical management of irradiation failures in T1-T2 squamous cell carcinoma of the glottic larynx

Virtaniemi JA, Hirvikoski PP, Kumpulainen EJ, Johansson RT, Kosma VM. 2001. Anticancer research. 21: 4185-4188

Syövän vai hoidon aiheuttamat oireet

Johansson R. 2001. Lääkärilehti. 56: 4613-4615

The incidence and etiology of postlaryngectomy pharyngocutaneous fistulae

Virtaniemi JA, Kumpulainen EJ, Hirvikoski PP, Johansson RT, Kosma V-M. 2001. Head and neck: journal for the sciences and specialties of the head and neck. 23: 29-33

3-cloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a rat thyroid gland carcinogen, does not affect serum levels of TSH and thyroid hormones

Komulainen H, Tuominen RK, Kosma V-M, Huuskonen H. 2000. Environmental toxicology and pharmacology. 8: 267-273

Adenovirus-mediated gene transfer into an experimental pancreatic tumour

Mäkinen K, Loimas S, Kosma VM, Wahlfors J, Ylä-Herttuala S, Alhava E, Jänne J. 2000. Scandinavian journal of surgery. 89: 99-103

Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods

Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Faseb journal. 14: 2230-2236

Combined respiratory effects of cold air with SO2 of NO2 in repeated 10-minute exposures of hyperventilating guinea pigs

Hälinen AI, Salonen RO, Pennanen AS, Kosma V-M. 2000. Inhalation toxicology. 12: 671-691

Combined respiratory effects of cold air with SO2 or NO2 in single 1-hour exposures of hyperventilating guinea pigs

Hälinen AI, Salonen RO, Pennanen AS, Kosma V-M. 2000. Inhalation toxicology. 12: 693-713

Do pulse-modulated or continuous 900 MHz rf fields enhance the carcinogenic effect of ionising radiation in mice?

Juutilainen J, Heikkinen P, Kosma V-M, Hongisto T, Huuskonen H, Hyysalo P, Komulainen H, Kumlin T, Lahtinen T, Lang S, Penttilä I, Puranen L, Väänänen A. Teoksessa: (toim.) , 2000. Non-Ionizing High-Feguence EM Radiations: Researching the Epidemiological and Clilnical Evidences. 1st International Medical Scientific Congress. s. 49-52. Societa 'Italiana di Statistica Medica

Enzyme replacement therapy in a mouse model of aspartylglycosaminuria

Dunder U, Kaartinen V, Valtonen P, Väänänen E, Kosma V-M, Heisterkamp N, Groffen J, Mononen I. 2000. Faseb journal. 14: 361-367

Evaluation of p21WAF1/CIP1 and cyclin D1 expression in the progression of superficial bladder cancer

Liukkonen T, Lipponen P, Raitanen M, Kaasinen E, Ala-opas M, Rajala P, Kosma V-M, Finnbladder Group. 2000. Urological research. 28: 285-292

Expression and prognostic value of alfa-, beta- and gamma-catenins in differentiated thyroid carcinoma

Böhm J, Niskanen L, Kiraly K, Kellokoski J, Eskelinen M, Hollmen S, Alhava E, Kosma V-M. 2000. Journal of clinical endocrinology and metabolism. 85: 4806-4811

Expression of activator protein 2 in prostate cancer is related to tumor differentiation and cell proliferation

Lipponen P, Aaltomaa S, Kellokoski J, Ala-Opas M, Kosma V-M. 2000. European urology. 37: 573-578

Expression of inducible nitric oxide synthase in colorectal cancer and its association with prognosis

Ropponen KM, Kellokoski JK, Lipponen PK, Eskelinen MJ, Alanne L, Alhava EM, Kosma V-M. 2000. Scandinavian journal of gastroenterology. 35: 1204-1211

Expression of transcription factor AP-2 alfa predicts survival in epithelial ovarian cancer

Anttila MA, Kellokoski JK, Moisio KI, Mitchell PJ, Saarikoski S, Syrjänen K, Kosma V-M. 2000. British journal of cancer. 82: 1974-1983

Failure in post-transcriptional processing is a possible inactivation mechanism of AP-2 alfa in cutaneous melanoma

Karjalainen JM, Kellokoski JK, Mannermaa AJ, Kujala HE, Moisio KI, Mitchell PJ, Eskelinen MJ, Alhava EM, Kosma VM. 2000. British journal of cancer. 82: 2015-2021

High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer

Anttila MA, Tammi RH, Tammi MI, Syrjänen KJ, Saarikoski SV, Kosma V-M. 2000. Cancer research. 60: 150-155

Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

Auvinen P, Tammi R, Parkkinen J, Tammi M, Ågren U, Johansson R, Hirvikoski P, Eskelinen M, Kosma V-M. 2000. American journal of pathology. 156: 529-536

Hypothyroidism after radiotherapy for laryngeal cancer

Kumpulainen EJ, Hirvikoski PP, Virtaniemi JA, Johansson RT, Simonen PM, Terävä MT, Asikainen RJ, Nykänen KJ, Kosma V-M. 2000. Radiotherapy and oncology. 57: 97-101

Hyvänlaatuisten tilojen sädehoito - uusi vanha hoitomuoto

Salminen E, Hakala T, Mäntylä M, Johansson R. 2000. Duodecim. 116: 2333-2338

Is the subsite distribution of laryngeal cancer related to smoking habits?

Virtaniemi JA, Hirvikoski PP, Kumpulainen EJ, Johansson RT, Pukkala E, Kosma V-M. 2000. Acta oncologica. 39: 77-79

Lack of cellular and humoral immunological responses to oats in adults with coeliac disease

Janatuinen EK, Kemppainen TA, Pikkarainen PH, Holm KH, Kosma V-M, Uusitupa MIJ, Mäki M, Julkunen RJK. 2000. Gut. 46: 327-331

Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains1

Viluksela M, Bager Y, Tuomisto JT, Scheu G, Unkila M, Pohjanvirta R, Flodström S, Kosma V-M, Mäki-Paakkanen J, Vartiainen T, Klimm C, Schramm K-W, Wärngård L, Tuomisto J. 2000. Cancer research. 60: 6911-6920

Loss of heterozygosity at chromosomes 3, 6, 8, 11, 16, and 17 in ovarian cancer: correlation to clinicopathological variables

Launonen V, Mannermaa A, Stenbäck F, Kosma V-M, Puistola U, Huusko P, Anttila M, Bloigu R, Saarikoski S, Kauppila A, Winqvist R. 2000. Cancer genetics and cytogenetics. 122: 49-54

Merkel cell carcinoma of the auricle

Virtaniemi J, Hirvikoski P, Pukkila M, Kumpulainen E, Johansson R, Kosma V-M. 2000. European archives of oto-rhino-laryngology. 257: 558-560

No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)

Komulainen H, Hakulinen P, Servomaa K, Makkonen K, Vasara R, Mäki-Paakkanen J, Kosma V-M. 2000. Environmental and molecular mutagenesis. 36: 292-300

Prognostic value of CD44 standard, variant isoforms 3 and 6 and alpha-catenin expression in local prostate cancer treated by radical prostatectomy

Aaltomaa S, Lipponen P, Viitanen J, Kankkunen J-P, Ala-opas M, Kosma V-M. 2000. European urology. 38: 555-562

Reduced CD44 standard expression is associated with tumour recurrence and unfavourable outcome in differentiated thyroid carcinoma

Böhm JP, Niskanen LK, Pirinen RT, Kiraly K, Kellokoski JK, Moisio KI, Eskelinen MJ, Tulla HE, Hollmen S, Alhava EM, Kosma V-M. 2000. Journal of pathology. 192: 321-327

Reduced expression of CD44v3 variant isoform is associated with unfavorable outcome in non-small cell lung carcinoma

Pirinen R, Hirvikoski P, Böhm J, Kellokoski J, Moisio K, Virén M, Johansson R, Hollmén S, Kosma V-M. 2000. Human pathology. 31: 1088-1095

Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma

Karjalainen JM, Tammi RH, Tammi MI, Eskelinen MJ, Ågren UM, Parkkinen JJ, Alhava EM, Kosma V-M. 2000. American journal of pathology. 157: 957-965

Steroid metabolism gene CYP17 polymorpsm and the develpment of breast cancer

Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V-M, Benhamou S, Vainio H, Uusitupa M, Hirvonen A. 2000. Cancer epidemiology biomarkers and prevention. 9: 1343-1348

The morphological changes in rat bladder after photodynamic therapy with 5-aminolaevulinic acid-induced protoporphyrin IX

Grönlund-Pakkanen S, Pakkanen TM, Talja M, Kosma V-M, Ala-Opas M, Alhava E. 2000. BJU international. 86: 126-132

The prognostic value of inducible nitric oxide synthase in local prostate cancer

Aaltomaa SH, Lipponen PK, Viitanen J, Kankkunen J-P, Ala-opas MY, Kosma V-M. 2000. BJU international. 86: 234-239

Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses

Sandmair A-M, Loimas S, Puranen P, Immonen A, Kossila M, Puranen M, Hurskainen H, Tyynelä K, Turunen M, Vanninen R, Lehtolainen P, Paljärvi L, Johansson R, Vapalahti M, Ylä-Herttuala S. 2000. Human gene therapy. 11: 2197-2205

p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women

Servomaa K, Kiuru A, Kosma V-M, Hirvikoski P, Rytömaa T. 2000. Journal of clinical pathology. 53: 24-30

Alfa-catenin expression has prognostic value in local and locally advanced prostate cancer

Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Kosma V-M. 1999. British journal of cancer. 80: 477-482

Association of p53, K-ras and proliferating cell nuclear antigen with rat lung lesions following exposure to simulated nuclear fuel particles

Kosma V-M, Lang PS, Servomaa MK, Leszczynski D, Rytömaa TJ. 1999. CANCER DETECTION AND PREVENTION. 23: 194-203

Bone recovery after a gluten-free diet: a 5-year follow-up study

Kemppainen T, Kröger H, Janatuinen E, Arnala I, Lamberg-Allardt C, Kärkkäinen M, Kosma V-M, Julkunen R, Jurvelin J, Alhava E, Uusitupa M. 1999. Bone. 25: 355-360

Downregulation of p21/WAF1 is related to advanced and dedifferentiated laryngeal squamous cell carcinoma

Hirvikoski P, Kellokoski JK, Kumpulainen EJ, Virtaniemi JA, Johansson RT, Kosma V-M. 1999. Journal of clinical pathology. 52: 440-444

Enhanced apoptosis correlates with poor survival in patients with laryngeal cancer but not with cell proliferation, bcl-2 or p53 expression

Hirvikoski P, Kumpulainen E, Virtaniemi J, Pirinen R, Salmi L, Halonen P, Johansson R, Kosma V-M. 1999. European journal of cancer. 35: 231-237

Evaluation of sensory irritation of delta3-carene and turpentine, and acceptable levels of monoterpenes in occupational and indoor environment

Kasanen J-P, Pasanen A-L, Pasanen P, Liesivuori J, Kosma V-M, Alarie Y. 1999. Journal of toxicology and environmental health: part a: current issues. 57: 89-114

Expression of cyclins A and D and p21 (waf1/cip1) proteins in renal cell cancer and their relation to clinicopathological variables and patient survival

Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Syrjänen K, Kosma V-M. 1999. British journal of cancer. 80: 2001-2007

Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate

Setälä LP, Tammi MI, Tammi RH, Eskelinen MJ, Lipponen PK, Ågren UM, Parkkinen J, Alhava EM, Kosma V-M. 1999. British journal of cancer. 79: 1133-1138

Irregular expression of hyaluronan and its CD44 receptor is associated with metastatic phenotype in laryngeal squamous cell carcinoma

Hirvikoski P, Tammi R, Kumpulainen E, Virtaniemi J, Parkkinen J J, Tammi M, Johansson R, Ågren U, Karhunen J, Kosma V-M. 1999. Virchows archiv. 434: 37-44

K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma

Hirvikoski P, Auvinen A, Servomaa K, Kiuru A, Rytömaa T, Makkonen K, Kosma V-M. 1999. Anticancer research. 19: 685-692

Laterality of laryngeal cancer

Virtaniemi JA, Hirvikoski PP, Kumpulainen EJ, Johansson RT, Kosma V-M. 1999. Acta oncologica

Measurement of prostate-specific antigen in detection of benign or malignant breast disease in women

Romppanen J, Keskikuru R, Kataja V, Eskelinen M, Kosma V-M, Savolainen K, Uusitupa M, Mononen I. 1999. British journal of cancer. 79: 1583-1587

Nitric oxide and proinflammatory cytokines in nasal lavage fluid associated with symptoms and exposure to moldy building microbes

Hirvonen M-R, Ruotsalainen M, Roponen M, Hyvärinen A, Husman T, Kosma V-M, Komulainen H, Savolainen K, Nevalainen A. 1999. American journal of respiratory and critical care medicine. 160: 1943-1946

Non-suppressed thyrotropin and elevated thyroglobulin are independent predictors of recurrence in differentiated thyroid carcinoma

Böhm J, Kosma V-M, Eskelinen M, Hollmen S, Niskanen M, Tulla H, Alhava E, Niskanen L. 1999. European journal of endocrinology. 141: 460-467

Osteoporosis in adult patients with celiac disease

Kemppainen T, Kröger H, Janatuinen E, Arnala I, Kosma V-M, Pikkarainen P, Julkunen R, Jurvelin J, Alhava E, Uusitupa M. 1999. Bone. 24: 249-255

Preoperative high type I collagen degradation marker ICTP reflects advanced breast cancer

Keskikuru R, Kataja V, Kosma V-M, Eskelinen M, Uusitupa M, Johansson R, Risteli L, Risteli J, Jukkola A. 1999. Anticancer research. 19: 4481-4484

Prognostic value and expression of p21 (waf1/cip 1) protein in prostate cancer

Aaltomaa S, Lipponen P, Eskelinen M, Ala-Opas M, Kosma VM. 1999. Prostate. 39: 8-15

Receiver-operating characteristics (ROC) curve analysis of cathepsin D and pS2 in breast disease: results from a prospective study

Eskelinen M, Kataja V, Hämäläinen E, Kosma V-M. 1999. Anticancer research. 19: 3463-3468

Reduced expression of alfa catenin is associated with poor prognosis in colorectal carcinoma

Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava EM, Kosma V-M. 1999. Journal of clinical pathology. 52: 10-16

Reply to S Jameson (to Villous atrophy and nutritional status in celiac disease)

Kemppainen TA, Uusitupa MI, Kosma V-M, Julkunen RJ. 1999. American journal of clinical nutrition

Sensory irritating potency of some microbial volatile organic compounds (MVOCs) and a mixture of five MVOCs

Korpi A, Kasanen J-P, Alarie Y, Kosma V-M, Pasanen A-L. 1999. ARCHIVES OF ENVIRONMENTAL HEALTH. 54: 347-352

Stent placement versus percutaneous transluminal angioplasty of human carotid arteries in cadavers in situ: distal embolization and findings at intravascular US, MR imaging, and histopathologic analysis

Manninen HI, Räsänen HT, Vanninen RL, Vainio P, Hippeläinen M, Kosma V-M. 1999. Radiology. 212: 483-492

p21 WAF1/CIP1 expression in stage I cutaneous malignant melanoma: its relationship with p53, cell proliferation and survival

Karjalainen JM, Eskelinen MJ, Kellokoski JK, Reinikainen M, Alhava EM, Kosma V-M. 1999. British journal of cancer. 79: 895-902

p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer

Anttila MA, Kosma V-M, Hongxiu J, Puolakka J, Juhola M, Saarikoski S, Syrjänen K. 1999. British journal of cancer. 79: 1870-1878

p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis

Ropponen KM, Kellokoski JK, Lipponen PK, Pietiläinen T, Eskelinen MJ, Alhava EM, Kosma V-M. 1999. British journal of cancer. 81: 133-140

Azaserine-induced rat pancreas tumor model with transplantable cultured cells

Mäkinen K, Loimas S, Kosma V-M, Wahlfors J, Pettengill OS, Longnecker DS, Johansson R, Alhava E. 1998. Pancreas. 16: 160-164

Clinical relevance of p53 index and expression of proliferating cell nuclear antigen and Ki-67 in gastric cancer

Setälä L, Kosma V-M, Lipponen P, Naukkarinen A, Nordling S, Hollmén S, Eskelinen M, Syrjänen K, Alhava E. 1998. Journal of cancer research and clinical oncology. 124: 497-502

Clinical significance of alfa-catenin, collagen IV, and Ki-67 expression in epithelial ovarian cancer

Anttila M, Kosma V-M, Ji H, Wei-Ling X, Puolakka J, Juhola M, Saarikoski S, Syrjänen K. 1998. Journal of clinical oncology. 16: 2591-2600

Cytoplasmic accumulation of alpha-catenin is associated with aggressive features in laryngeal squamous-cell carcinoma

Hirvikoski P, Kumpulainen EJ, Virtaniemi JA, Helin HJ, Rantala I, Johansson RT, Juhola M, Kosma V-M. 1998. International journal of cancer. 79: 546-550

Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma

Karjalainen JM, Kellokoski JK, Eskelinen MJ, Alhava EM, Kosma V-M. 1998. Journal of clinical oncology. 16: 3584-3591

Effects of 50 Hz magnetic fields on UV-induced skin tumourigenesis in ODC-transgenic and non-transgenic mice

Kumlin T, Kosma V-M, Alhonen L, Jänne J, Komulainen H, Lang S, Rytömaa T, Servomaa K, Juutilainen J. 1998. International journal of radiation biology. 73: 113-121

Epidermal ornithine decarboxylase and polyamines in mice exposed to 50 Hz magnetic fields and UV radiation

Kumlin T, Alhonen L, Jänne J, Lang S, Kosma V-M, Juutilainen J. 1998. Bioelectromagnetics. 19: 388-391

Expression of CD44 and variant proteins in human colorectal cancer and its relevance for prognosis

Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma V-M. 1998. Scandinavian journal of gastroenterology. 33: 301-309

Expression of CD44 standard and variant-v6 proteins in transitional cell bladder tumours and their relation to prognosis during a long-term follow-up

Lipponen P, Aaltoma S, Kosma V-M, Ala-Opas M, Eskelinen M. 1998. Journal of pathology. 186: 157-164

Expression of hyaluronan in normal and dysplastic bronchial epithelium and in squamous cell carcinoma of the lung

Pirinen RT, Tammi RH, Tammi MI, Pääkkö PK, Parkkinen JJ, Ågren UM, Johansson RT, Viren MMT, Törmänen U, Soini YMJ, Kosma V-M. 1998. International journal of cancer. 79: 251-255

Expression of p21(waf1/cip1) protein in transitional cell bladder tumours and its prognostic value

Lipponen P, Aaltomaa S, Eskelinen M, Ala-Opas M, Kosma V-M. 1998. European urology. 34: 237-243

Human carotid arteries: correlation of intravascular US with angiographic and histopathologic findings

Manninen HI, Räsänen H, Vanninen RL, Berg M, Hippeläinen M, Saari T, Yang X, Karkola K, Kosma V-M. 1998. Radiology. 206: 65-74

Kurkunpään primaarinen pahanlaatuinen melanooma

Virtaniemi J, Hirvikoski P, Kumpulainen E, Johansson R, Kulju T, Hujala K, Kosma V-M. 1998. Duodecim. 114: 1339-1342

Lipid peroxidation products and antioxidant capacity in portal venous and systemic arterial plasma during gradual intestinal ischemia and reperfusion in pigs

Juvonen PO, Paajanen HEK, Heino AA, Koski EJ, Merasto M, Hartikainen JEK, Kosma VM, Alhava EM, Takala JA. 1998. European surgical research. 30: 95-101

Markers of cartilage and synovial metabolism in joint fluid and serum of patients with chondromalacia of the patella

Väätäinen U, Lohmander LS, Thonar E, Hongisto T, Ågren U, Rönkkö S, Jaroma H, Kosma V-M, Tammi M, Kiviranta I. 1998. Osteoarthritis and cartilage. 6: 115-124

Mitotic rate and S-phase fraction as prognostic factors in stage I cutaneous malignant melanoma

Karjalainen JM, Eskelinen MJ, Nordling S, Lipponen PK, Alhava EM, Kosma V-M. 1998. British journal of cancer. 77: 1917-1925

Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet - association with the grade of mucosal villous atrophy1-3

Kemppainen TA, Kosma V-M, Janatuinen EK, Julkunen RJ, Pikkarainen PH, Uusitupa MI. 1998. American journal of clinical nutrition. 67: 482-487

Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers

Kasanen J-P, Pasanen A-L, Pasanen P, Liesivuori J, Kosma V-M, Alarie Y. 1998. Archives of toxicology. 72: 514-523

Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer

Ropponen K, Tammi M, Parkkinen J, Eskelinen M, Tammi R, Lipponen P, Ågren U, Alhava E, Kosma V-M. 1998. Cancer research. 58: 342-347

Carcinogenicity of the drinking water mutagen 3-Cloro-4-(dickloromethyl)-5-hydroxy-2(5H)-furanone in the rat

Komulainen H , Kosma V-M, Vaittinen S-L, Vartiainen T , Kaliste-Korhonen E , Lötjönen S , Tuominen RK, Tuomisto J. 1997. Journal of the national cancer institute. 89: 848-856

Carcinogenicity of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the rat

Komulainen H, Kosma V-M, Vaittinen S-L, Vartiainen T, Kaliste-Korhonen E, Lötjönen S, Tuominen RK, Tuomisto J. Teoksessa: Vartiainen T, Komulainen H(toim.) , 1997. 7th Nordic Symposium on Organic Pollutants. s. 118-121.

Comparison of DNA ploidy and s-phase fraction with prognostic factors in gastric cancer

Setälä LP, Nordling S, Kosma V-M, Lipponen PK, Eskelinen MJ, Hollmén SM-L, Syrjänen KJ, Alhava EM. 1997. Analytical and quantitative cytology and histology. 19: 524-532

Correlation of MIB-1 antigen expression with transcription factors Skn-1, Oct-1, AP-2, and HPV type in cervical intraepithelial neoplasia

Hietala KA, Kosma V-M, Syrjänen KJ, Syrjänen SM, Kellokoski JK. 1997. Journal of pathology. 183: 305-310

Expression of hyaluronan in benign and malignant breast lesions

Auvinen PK, Parkkinen JJ, Johansson RT, Ågren UM, Tammi RH, Eskelinen MJ, Kosma V-M. 1997. International journal of cancer. 74: 477-481

Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma

Hiltunen MO, Alhonen L, Koistinaho J, Myöhänen S, Pääkkönen M, Marin S, Kosma V-M, Jänne J. 1997. International journal of cancer. 70: 644-648

Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer

Hiltunen MO, Koistinaho J, Alhonen L, Myöhänen S, Marin S, Kosma V-M, Pääkkönen M, Jänne J. 1997. British journal of cancer. 76: 1124-1130

Molecular epidemiological study of human rectal cancer induced by radiotherapy

Rytömaa T, Servomaa K, Kiuru A, Auvinen A, Kosma V-M, Hirvikoski P, Makkonen K. Teoksessa: Daburon F, Martin M(toim.) , 1997. Proceedings of the 27th Annual Meeting of the European Society for Radiation Biology. 100th Becquerel Anniversary. s. 257-258. Éditions de Physique

Mutations in the p53 tumour suppressor gene and other molecular changes in cancers among Chernobyl cleanup workers from Estonia

Servomaa K, Kiuru A, Kosma V-M, Tekkel M, Rahu M, Veidebaum T, Auvinen A, Hakulinen T, Boice JD Jr, Inskip P, Rytömaa T. Teoksessa: (toim.) , 1997. Health Effects of Low Dose Radiation. Challenges of the 21st Century. Proceedings. s. 92-95. British Nuclear Energy Society

Nuclear morphometry as a predictor of disease outcome in gastric cancer

Setälä L, Lipponen P, Kosma V-M, Marin S, Eskelinen M, Syrjänen K, Alhava E. 1997. Journal of pathology. 181: 46-50

Prognostic factors in gastric carcinoma

Setälä L, Kosma V-M, Eskelinen M, Syrjänen K, Alhava E. 1997. British journal of cancer

Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer

Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma V-M,. 1997. Journal of pathology. 182: 318-324

Serum tumour markers CEA,AFP,CA 15-3,TPS and neu in diagnosis of breast cancer

Eskelinen M, Kataja V, Hämäläinen E, Kosma V-M, Penttilä I, Alhava E. 1997. Anticancer research. 17: 1231-1234

p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma

Hirvikoski P, Kumpulainen E, Virtaniemi J, Johansson R, Haapasalo H, Marin S, Halonen P, Helin H, Raitiola H, Pukander J, Kellokumpu-Lehtinen P, Kosma V-M. 1997. Journal of clinical oncology. 15: 3111-3120

Comparison of classic and quantitative prognostic factors in colorectal cancer

Ropponen K, Eskelinen M, Kosma V-M, Lipponen P, Paakkinen P, Alhava E. 1996. Anticancer research. 16: 3875-3882

Genotoxicity and carcinogenicity of MX and other chlorinated furanones

Tuomisto J, Komulainen H, Kosma V-M, Mäki-Paakkanen J, Vartiainen T. Teoksessa: Dybing E, Solbakken AL(toim.) , 1996. 25-års jubileum for toksikologien ved Statens institutt for folkehelse 1971-1996. Sammendrag fra jubileumseminaret og historiske tilbakeblikk. s. 17-19. Statens institutt for folkehelse

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

Setälä LP, Kosma V-M, Marin S, Lipponen PK, Eskelinen MJ, Syrjänen KJ, Alhava EM. 1996. British journal of cancer. 74: 766-772

Standardized mitotic counts in breast cancer evaluation of the method

Collan YUI, Kuopio T, Baak JPA, Becker R, Bogomoletz WV, Deverell M, Diest P van, Galen C van, Gilchrist K, Javed A, Kosma V-M, Kujari H, Luzi P, Mariuzzi GM, Matze E, Montironi R, Scarpelli M, Sierra D, Sisti S, Toikkanen S, Tosi P, Whimster WF, Wis. 1996. Pathology research and practice. 192: 931-941

The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer

Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1996. Journal of cancer research and clinical oncology. 122: 687-692

A comparison of diets with and without oats in adults with celiac disease

Janatuinen EK, Pikkarainen PH, Kemppainen TA, Kosma V-M, Järvinen RMK, Uusitupa MIJ, Julkunen RJK. 1995. The new england journal of medicine. 333: 1033-1037

Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments

Salonen RO, Randell JT, Hälinen AI, Pennanen AS, Kosma V-M, Pekkarinen H, Ruuskanen J, Tukiainen H. Teoksessa: Kämäri J, Tolvanen M, Anttila P, Salonen RO(toim.) , 1995. Proceedings of the 10th World Clean Air Congress. Vol. 3. Impacts and Management. N:o 614. s. [3 p.].

Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis

Lipponen P, Pietiläinen T, Kosma V-M, Aaltomaa S, Eskelinen M, Syrjänen K. 1995. Journal of pathology. 177: 49-55

Biokinetics of nuclear fuel compounds and biological effects of nonuniform radiation

Lang S, Servomaa K, Kosma V-M, Rytömaa T. 1995. Environmental health perspectives. 103: 920-934

Dust toxicity in rat alveolar macrophage cultures

Collan Y, Kosma V-M. Teoksessa: O'Hare S, Atterwill CK(toim.) , 1995. Methods in Molecular Biology, vol 43: In Vitro Toxicity Testing Protocols. s. 43-49. Humana Press

Effects of simulated nuclear fuel particles on the histopathology and CYP enzymes in the rat lung and liver

Pasanen M, Lang S, Kojo A, Kosma V-M. 1995. Environmental research. 70: 126-133

Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival

Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1995. Anticancer research. 15: 959-964

Expression of p53 protein has no independent prognostic value in breast cancer

Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1995. Journal of pathology. 177: 225-232

Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival

Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K. 1995. European journal of cancer. 31A: 329-333

Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration

Alhonen L, Halmekytö M, Kosma V-M, Wahlfors J, Kauppinen R, Jänne J. 1995. International journal of cancer. 63: 402-404

Prognostic value of cathepsin-D expression in female breast cancer

Aaltonen M, Lipponen P, Kosma V-M, Aaltomaa S, Syrjänen K. 1995. Anticancer research. 15: 1033-1038

Subchronic toxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(2H)-furanone (MX) in Wistar rats

Vaittinen S-L, Komulainen H, Kosma V-M, Julkunen A, Mäki-Paakkanen J, Jansson K, Vartiainen T, Tuomisto J. 1995. Food and chemical toxicology. 33: 1027-1037

Apoptosis in breast cancer as related to histopathological characteristics and prognosis

Lipponen P, Aaltomaa S, Kosma V-M, Syrjänen K. 1994. European journal of cancer. 30A: 2068-2073

Apparent radiation-specific point mutation in the tumour suppressor gene p53 in malignant lung tumours in rat

Servomaa K, Leszczynski D, Lang S, Kosma V-M, Rytömaa T. Teoksessa: Chadwick KH, Cox R, Leenhouts HP, Thacker J(toim.) , 1994. Molecular Mechanisms in Radiation Mutagenesis and Carcinogenesis. s. 223-228. European Commission

Distribution and short-term effects of intratracheally instilled neutron-irradiated UO2 particles in the rat

Lang Sakari, Kosma Veli-Matti, Kumlin Timo, Hälinen Arja, Salonen Raimo O, Servomaa Kristiina, Rytömaa Tapio, Ruuskanen Juhani. 1994. Environmental research. 65: 119-131

Radiation-induced concomitant overexpression of p53, p62c-fos and p21n-ras in mouse epidermis

Leszcynski D, Servomaa K, Lang S, Kosma V-M, Rytömaa T. 1994. Cell proliferation. 27: 517-528

Sapphire probe versus bare fiber in interstitial laser hyperthermia (ILH). An experimental study with wistar rats

Mäkinen K, Nuutinen P, Eskelinen M, Kosma V-M, Alhava E. 1994. Anticancer research. 14: 1023-1026

The influence of dichloromethylence bisphosphonate on the healing of a long bone fracture, composition of bone mineral and histology of bone in the rat

Hyvönen PM, Karhi T, Kosma V-M, Liimola-Luoma L, Hanhijärvi H. 1994. Basic and clinical pharmacology and toxicology. 75: 384-390

The influence of dichloromethylene bisphosphonate on the healing of a long bone fracture, composition of bone mineral and histology of bone in the rat

Hyvönen PM, Karhi T, Kosma V-M, Liimola-Luoma L, Hanhijärvi H. 1994. Basic and clinical pharmacology and toxicology. 75: 384-390

Toxic effects and execretion in urine of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX) in the rat after a single oral dose

Komulainen H, Huuskonen H, Kosma V-M, Lötjönen S, Vartiainen T. 1994. Archives of toxicology. 68: 398-400

Breast cancer in young women: clinical, histological and morphometric prognostic factors

Eskelinen M, Lipponen P, Aaltomaa S, Kosma VM, Syrjänen K, Alhava E. 1992. Anticancer research. 12: 1237-1242

Clinical, histological and quantitative prognostic factors in cutaneous malignant melanoma

Karjalainen J, Eskelinen M, Kosma VM, Lipponen P, Tuominen L, Alhava E. 1992. Anticancer research. 12: 1507-1512

DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors in female breast cancer

Eskelinen M, Lipponen P, Papinaho S, Aaltomaa S, Kosma VM, Klemi P, Syrjänen K. 1992. International journal of cancer. 51: 555-561

DNA ploidy, S-phase fraction and mitotic indices as predictors of female breast cancer

Lipponen P, Papinaho S, Eskelinen M, Klemi P, Aaltomaa S, Kosma VM, Syrjänen K. 1992. Anticancer research. 12: 1533-1538

Histological assessment of the prognostic factors in female breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. Oncology. 49: 1-8

Lymphocyte infiltrates as a prognostic variable in female breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. European journal of cancer. 28: 859-864

Mitotic indexes as prognostic predictors in female breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. Journal of cancer research and clinical oncology. 118: 75-81

Nuclear morphometry and DNA flow cytometry as prognostic factors in female breast cancer

Aaltomaa S, Lipponen P, Papinaho S, Klemi P, Kosma VM, Marin S, Eskelinen M, Alhava E, Syrjänen K. 1992. EUROPEAN JOURNAL OF SURGERY. 158: 135-141

Prediction of outcome after first recurrence of breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. EUROPEAN JOURNAL OF SURGERY. 158: 13-18

Primary malignant schwannoma of the small bowel

Eskelinen M, Pasanen P, Kosma VM. 1992. Scandinavian journal of surgery. 81: 326-328

Prognostic factors after 5 years follow-up in female breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. Oncology. 49: 93-98

Prognostic factors in invasive lobular carcinoma of the breast

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. DIAGNOSTIC ONCOLOGY. 2: 74-79

Sex steroid receptors, S-phase fraction and DNA ploidy ad determinants of the risk of relapse and death of female breast cancer

Lipponen P, Eskelinen M, Papinaho S, Klemi P, Aaltomaa S, Kosma VM, Syrjänen K. 1992. Anticancer research. 12: 677-682

The changing importance of prognostic factors in breast cancer during a long-term follow-up

Lipponen P, Aaltomaa S, Eskelinen M, Kosma VM, Marin S, Syrjänen K. 1992. International journal of cancer. 51: 698-702

Tumor size, nuclear morphometry, mitotic indices as prognostic factors in axillary-lymphnode-positive breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, Syrjänen K. 1992. European surgical research. 24: 160-168

Xanthogranuloma Juvenile - a rare cause of orbital swelling in adulthood

Rouhiainen H, Nerdrum K, Puustjärvi T, Kosma VM. 1992. Ophthalmologica. 204: 162-165

Dithranol (anthralin)-induced skin irritation in sencar, C57 BL/6 and NMRI mice

Viluksela M, Kosma V-M. 1991. Basic and clinical pharmacology and toxicology. 69: 96-104

Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma

Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. Anticancer research. 11: 1701-1706

Hormone receptors as prognostic factors in female breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. Annals of medicine. 23: 643-648

Mesenchymoma of the chest wall in children

Eskelinen M, Kosma V-M, Vainio J. 1991. Annals of thoracic surgery. 52: 285-290

Prognostic factors in axillary lymphonode negative (pN-) breast carcinomas

Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. European journal of cancer. 27: 1555-1559

Prognostic scores combining clinical, histological and morphometric variables in assessment of the disease outcome in female breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. International journal of cancer. : 49-886-892

The significance of nuclear morphometric variables as prognostic predictors in breast cancer

Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K. 1991. Anticancer research. 11: 1663-1670

Urinary excretion of ethylenethiourea and kidney morphology in rats after continuous oral exposure to nabam or ethylenethiourea

Kurttio P, Savolainen K, Naukkarinen A, Kosma V-M, Tuomisto L, Penttilä I, Jolkkonen J. 1991. Archives of toxicology. 65: 381-385

Potential of nuclear morphometry and volume corrected mitotic index (M/V-index) in grading transitional cell carcinoma of the urinary bladder

Lipponen PK, Kosma V-M, Collan Y, Kulju T, Kosunen O, Eskelinen M. 1990. European urology. 17: 333-337

Verrucous carcinoma of the anus containing human papillomavirus type 16 NDA detected by in situ hybridization. A *case report

Chang F, Kosunen O, Kosma V-M, Syrjänen S, Lahtinen J, Syrjänen K. 1990. Sexually transmitted infections. 66: 342-345

Morphometric study of human myocardium in acquired valvular diseases

Jantunen E, Halinen MO, Romppanen T, Kosma VM, Collan Y. 1989. Annals of medicine. 21: 435-440

Morphometry in cancer diagnostics

Collan Y, Kosma VM. Teoksessa: (toim.) , 1989. . s. 134-144.

Tutkimusryhmät

Avainsanat

A FinnGen pilot clinical recall study for Alzheimer’s disease

Nuclei instance segmentation from histopathology images using Bayesian dropout based deep learning

Predicting cell type counts in whole slide histology images using evidential multi-task learning

A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Area-based breast percentage density estimation in mammograms using weight-adaptive multitask learning

Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors

Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies

Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Rare germline copy number variants (CNVs) and breast cancer risk

A case-only study to identify genetic modifiers ofbreast cancer risk for BRCA1/BRCA2mutationcarriers

Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

High Cell-Free DNA Integrity Is Associated with Poor Breast Cancer Survival

Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers

Multi-level dilated residual network for biomedical image segmentation

The debatable presence of PIWI-interacting RNAs in invasive breast cancer

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer

Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors

Peritumor to Tumor Apparent Diffusion Coefficient Ratio Is Associated With Biologically More Aggressive Breast Cancer Features and Correlates With the Prognostication Tools

Predicting Breast Cancer Risk Using Interacting Genetic and Demographic Factors and Machine Learning

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Genome-wide association study of germline variants and breast cancer-specific mortality

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

Machine learning identifies interacting genetic variants contributing to breast cancer risk: a case study in Finnish cases and controls

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity

Tumor-infiltrating lymphocytes associate with outcome in non-endemic nasopharyngeal carcinoma : a multicenter study

Association analysis identifies 65 new breast cancer risk loci

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Body mass index and breast cancer survival: a Mendelian randomization analysis

Combined gene therapy using AdsVEGFR2 and AdsTie2 with chemotherapy reduces the growth of human ovarian cancer and formation of ascites in mice

FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study

TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

Tenascin-C and fibronectin expression divide early stage tongue cancer into low-and high-risk groups

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Genes associated with histopathologic features of triple negative breast tumors predict molecular subtypes

Genetic predisposition to ductal carcinoma in situ of the breast

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

A simple novel prognostic model for early stage oral tongue cancer

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis