Jenni Küblbeck

Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate

Pitkänen, Sini; Hakomäki, Henriikka; Kärkkäinen, Olli; Lehtonen, Marko; Das, Sreejita; Rysä, Jaana; Küblbeck, Jenni; Levonen, Anna-Liisa, 2026, Molecular metabolism, 110, 102412. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Activation of steroid hormone receptors by metabolism-disrupting chemicals

Pitkänen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A; Palvimo, Jorma J; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Küblbeck, Jenni; Honkakoski, Paavo, 2025, Toxicology and applied pharmacology, 499, 117335. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review

Gogola, Tomasz; Pitkänen, Sini; Huovinen, Marjo; Laitinen, Heikki; Küblbeck, Jenni, 2025, Environmental research, 273, 121186. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy

Happonen, Emilia; Dang, Yijing; Wang, Jiajia; Saarela, Silja; Sivonen, Minna; Zakir, Mohammed; Laari, Milla-Iida; Constantinou, Yiannis; Tamarov, Konstantin; Hakkarainen, Henri; Montaser, Ahmed Bisher; Leinonen, Henri; Küblbeck, Jenni; Örd, Tiit; Taipale, Mari; Kaikkonen, Minna; Liu, Ruixian; Klefström, Juha; Yu, Haijun; Xu, Zhiai; Lehto, Vesa-Pekka; Xu, Wujun, 2025, Acs applied materials and interfaces, 17, 33, 46521-46534. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors

Rashidian, Azam; Pitkänen, Sini; Maltarollo, Vinicius Goncalves; Schoppmeier, Ulrich; Shevchenko, Ekaterina; Medarametla, Prasanthi; Poso, Antti; Küblbeck, Jenni; Honkakoski, Paavo; Kronenberger, Thales, 2025, Journal of chemical information and modeling, 65, 8, 4148-4162. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Heikkinen, Tia; Küblbeck, Jenni; Rysä, Jaana, 2025, Archives of toxicology, 99, 5, 1749-1767. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Nuclear Receptors CAR and PXR as Cardiometabolic Regulators

Hukkanen, Janne; Küblbeck, Jenni; Hakkola, Jukka; Rysä, Jaana, 2025, Pharmacological research, 219, 107892. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies

Galvez B. Pedreira, Júlia; Woelffing, Pascal; Schwarz, Moritz; Ebner, Simon; Rudalska, Ramona; Masberg, Benedikt; Esposito, Aylin; Rashidian, Azam; Schevchenko, Ekaterina; Smutna, Lucie; Pavek, Petr; Kublbeck, Jenni; Kronenberger, Thales; Zender, Lars; Lämmerhofer, Michael; Dauch, Daniel; Laufer, Stefan A, 2025, Journal of medicinal chemistry, 68, 7, 7180-7196. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Hakomäki, Henriikka; Pitkänen, Sini; Levonen, Anna-Liisa; Honkakoski, Paavo; Greco, Dario; D'Alessandro, Nicoletta; Saarimäki, Laura Aliisa; Viegas, Susana; Godinho, Cristina; Fyhrquist, Nanna; Wincent, Emma; Lauschke, Volker M; Hukkanen, Janne; Hakkola, Jukka; Vallier, Ludovic; Fortino, Vittorio; Afantitis, Antreas; Sawatani, Toshiaki; Guzman, Tereso J; Cnop, Miriam; Nawrot, Tim; Harlid, Sophia; Vinnars, Marie-Therese; Tardon, Adonina; Grimalt, Joan O; Küblbeck, Jenni; Rysä, Jaana, 2025, Open research Europe, 4, 194. B1 Kirjoitus tieteellisessä aikakauslehdessä

Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen

Marzouk, Mohamed Akmal; Greco, Sara; Gbahou, Florence; Küblbeck, Jenni; Labani, Nedjma; Jockers, Ralf; Holzgrabe, Ulrike; Wiesmueller, Lisa; Zlotos, Darius P, 2024, ACS omega, 9, 48, 1-15. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Adinolfi, Simone; Patinen, Tommi; Jawahar Deen, Ashik; Pitkänen, Sini; Härkönen, Jouni; Kansanen, Emilia; Küblbeck, Jenni; Levonen, Anna-Liisa, 2023, Redox biology, 63, 102726. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Abdelmalek, Carine M.; Hu, Zexi; Kronenberger, Thales; Küblbeck, Jenni; Kinnen, Franziska J.M.; Hesse, Salma S.; Malik, Afsin; Kudolo, Mark; Niess, Raimund; Gehringer, Matthias; Zender, Lars; Witt-Enderby, Paula A.; Zlotos, Darius P.; Laufer, Stefan A., 2022, Journal of medicinal chemistry, 65, 6, 4616-4632. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Hormonihäirikköjä lautasella?

Küblbeck, Jenni; Pitkänen, Sini, 2022, Kehittyvä elintarvike, 33, 1, 16-17. D1 Artikkeli ammattilehdessä

Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines

Järvenpää, Joni; Rahnasto-Rilla, Minna; Lahtela-Kakkonen, Maija; Küblbeck, Jenni, 2022, Biomedicine and pharmacotherapy, 147, 112652. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Sakhteman, A; Failli, M; Kublbeck, J; Levonen, AL; Fortino, V, 2021, Environment international, 156, 106751. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Tenhunen, Jonna; Kucera, Tomá¨; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Dole¸al, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna, 2021, Biomedicine and pharmacotherapy, 138, 111452. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Rahnasto-Rilla, Minna; Järvenpää, Joni; Huovinen, Marjo; Schroderus, Anna-Mari; Ihantola, Emmi-Leena; Küblbeck, Jenni; Khadeer, Mohammed; Moaddel, Ruin; Lahtela-Kakkonen, Maija, 2020, Biomedicine and pharmacotherapy, 131, 110701. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P, 2019, PLoS ONE, 14, 3, e0214338. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Isoflavonien turvallisuus ja tutkimuksen haasteet

Küblbeck, Jenni; Huovinen, Marjo, 2019, Dosis, 35, 3, 274-289. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H, 2019, Planta medica, 85, 6, 453-464. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P, 2019, Molecular pharmacology, 96, 5, 655-663. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Prantner, Viktoria; Cinnamon, Yuval; Küblbeck, Jenni; Molnár, Ferdin; Honkakoski, Paavo, 2018, Nuclear Receptor Research, 5, 101386. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo, 2016, Journal of pharmaceutical sciences, 105, 2, 941-949. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo, 2016, Tissue engineering, 22, 13-14, 971-984. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Küblbeck Jenni, Zancanella Vanessa, Prantner Victoria, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo, Giantin Mery, 2015, Xenobiotica, 46 (2016), 3, 200-210. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Improved assays for xenosensor activation based on reverse transfection

Küblbeck Jenni, Anttila Teemu, Pulkkinen Juha T, Honkakoski Paavo, 2015, Toxicology in vitro, 29, 7, 1759-1765. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Giantin M., Zancanella V., Kueblbeck J., Prantner V., Sansonetti F., Honkakoski P., Dacasto M., 2015, Journal of veterinary pharmacology and therapeutics.

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Mattinen Laura, Kublbeck Jenni, Rechardt Oona, Honkakoski Paavo, Rautio Jari, 2014, Drug metabolism letters, 8, 2, 77-87. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Honkakoski Paavo, Molnár Ferdinand, Kublbeck Jenni, 2014, Dosis, 30, 3, 193. B1 Kirjoitus tieteellisessä aikakauslehdessä

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T, 2014, Molecular and cellular endocrinology, 387, 8-18. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

An update on the constitutive androstane receptor (CAR)

Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo, 2013, Drug metabolism and drug interactions, 28, 2, 79-93. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo, 2013, Toxicology in vitro, 27, 6, 2005-2012. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Characterization of human cytochrome P450 induction by pesticides

Abass Khaled, Lämsä Virpi, Reponen Petri, Küblbeck Jenni, Honkakoski Paavo, Mattila Sampo, Pelkonen Olavi, Hakkola Jukka, 2012, Toxicology, 294, 17-26. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Molecular dynamics simulations for human CAR inverse agonists

Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo, 2012, Journal of chemical information and modeling, 52, 457-464. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

Ma Liang, Barker Jeremy, Zhou Changchun, Li Wei, Zhang Jing, Lin Biaoyang, Foltz Gregory, Küblbeck Jenni, Honkakoski Paavo, 2012, Biomaterials, 33, 4353-4361. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo, 2011, Molecular pharmaceutics, 8, 2424-2433. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Use of comprehensive screening methods to detect selective human CAR activators

Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand, 2011, Biochemical pharmacology, 82, 1994-2007. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P, 2010, European journal of pharmaceutical sciences, 40, 263-272. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B, 2008, Biochemical pharmacology, 76, 1288-1297. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P, 2008, Journal of medicinal chemistry, 51, 7181-7192. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity

Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W, 2007, Journal of molecular graphics and modelling, 25, 644-657. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tarkenna hakuasi

Tutkimusryhmät

Projektit

Avainsanat

Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate

Activation of steroid hormone receptors by metabolism-disrupting chemicals

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review

Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy

Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Nuclear Receptors CAR and PXR as Cardiometabolic Regulators

Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Hormonihäirikköjä lautasella?

Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

The EDCMET project: Metabolic effects of endocrine disruptors

A Reverse Transfection Method for Screening of Nuclear Receptor Activators

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Isoflavonien turvallisuus ja tutkimuksen haasteet

Metabolism of Scoparone in Experimental Animals and Humans

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Improved assays for xenosensor activation based on reverse transfection

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

An update on the constitutive androstane receptor (CAR)

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Characterization of human cytochrome P450 induction by pesticides

Molecular dynamics simulations for human CAR inverse agonists

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Use of comprehensive screening methods to detect selective human CAR activators

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity