Tarja Malm

Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level

Urbanek, Agnieszka; Garland, Emma F; Prescott, Emily E; King, Marianne C; Olerinyova, Anna; Wareing, Hollie E; Georgieva, Nia; Bradshaw, Ellie L; Tzokov, Svetomir B; Knight, Alexander; Tartakovskii, Alexander I; Malm, Tarja; Highley, J Robin; De, Suman. 2025. Advanced science. 12: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha. 2025. Journal of neuroinflammation. 22: . 64 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Xia, Zengjie; Prescott, Emily E; Urbanek, Agnieszka; Wareing, Hollie E; King, Marianne C; Olerinyova, Anna; Dakin, Helen; Leah, Tom; Barnes, Katy A; Matuszyk, Martyna M; Dimou, Eleni; Hidari, Eric; Zhang, Yu P; Lam, Jeff Y. L; Danial, John SH; Strickland, Michael R; Jiang, Hong; Thornton, Peter; Crowther, Damian C. Ohtonen, Sohvi; Gómez-Budia, Mireia; Bell, Simon M; Ferraiuolo, Laura; Mortiboys, Heather; Higginbottom, Adrian; Wharton, Stephen B; Holtzman, David M; Malm, Tarja; Ranasinghe, Rohan . 2024. Nature communications. 15: . 4695 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI

Lietzén, Martin S.; Mari, Andrea; Ojala, Ronja; Hentilä, Jaakko; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Saunavaara, Virva; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C.. 2024. Biomolecules. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Emerging Models to Study Human Microglia In vitro

Jäntti, Henna; Kistemaker, Lois; Buonfiglioli, Alice; De Witte, Lot D.; Malm, Tarja; Hol, Elly M.. Teoksessa: Tremblay, Marie-Ève; Verkhratsky, Alexei(toim.) , 2024. Microglia: Physiology, Pathophysiology and Therapeutic Potential. s. 545-568. Springer A3 Kirjan tai muun kokoomateoksen osa

Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)

Jalo, Anna; Helin, Jatta S; Hentilä, Jaakko; Nissinen, Tuuli A; Honkala, Sanna M; Heiskanen, Marja A; Löyttyniemi, Eliisa; Malm, Tarja; Hannukainen, Jarna C. 2024. Journal of functional morphology and kinesiology. 9: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI

Lietzén, Martin S.; Guzzardi, Maria Angela; Ojala, Ronja; Hentilä, Jaakko; Heiskanen, Marja A.; Honkala, Sanna M.; Lautamäki, Riikka; Löyttyniemi, Eliisa; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C.. 2024. Nutrients. 16: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

Christ, Wanda; Kapell, Sebastian; Sobkowiak, Michal J; Mermelekas, Georgios; Evertsson, Björn; Sork, Helena; Saher, Osama; Bazaz, Safa; Gustafsson, Oskar; Cardenas, Eduardo I; Villa, Viviana; Ricciarelli, Roberta; Sandberg, Johan K; Bergquist, Jonas; Sturchio, Andrea; Svenningsson, Per; Malm, Tarja; Espay, Alberto J; Pernemalm, Maria; Lindén, Anders; Klingström, Jonas; El Andaloussi, Samir; Ezzat, Kariem. 2024. Acs chemical neuroscience. 15: 4095-4104 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling

Giudice, Luca; Mohamed, Ahmed; Malm, Tarja. 2024. PLoS computational biology. 20: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari. 2024. Nature cardiovascular research. 3: 474-491 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Mussalo, Laura; Lampinen, Riikka; Avesani, Simone; Závodná, Táňa; Krejčík, Zdeněk; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Jalava, Pasi; Kanninen, Katja M. 2024. Redox biology. 75: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Saveleva, Liudmila; Cervena, Tereza; Mengoni, Claudia; Sima, Michal; Krejcik, Zdenek; Vrbova, Kristyna; Sikorova, Jitka; Mussalo, Laura; de Crom, Tosca O E; Šímová, Zuzana; Ivanova, Mariia; Shahbaz, Muhammad Ali; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Ikram, M Arfan; Jalava, Pasi I; Malm, Tarja; Chew, Sweelin; Vojtisek‐Lom, Michal; Topinka, Jan; Giugno, Rosalba; Rössner, Pavel; Kanninen, Katja M. 2024. Alzheimer's & dementia. 20: 8825-8843 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka. 2024. Glia. 2025; 73: 159-174 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre, . 2024. Cell reports. 43: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja. 2023. Alzheimer's & dementia. 2024; 20: 954-974 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location

Ojala, Ronja; Hentilä, Jaakko; Lietzén, Martin S; Arponen, Milja; Heiskanen, Marja A; Honkala, Sanna M; Virtanen, Heidi; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Heinonen, Olli J; Malm, Tarja; Lahti, Leo; Rinne, Juha; Eskola, Olli; Rajander, Johan; Pietiläinen, Kirsi H; Kaprio, Jaakko; Ivaska, Kaisa K.; Hannukainen, Jarna C. 2023. Diabetes obesity and metabolism. 2024; 26: 251-261 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles

Es-Haghi, Masoumeh; Neustroeva, Olga; Chowdhury, Iftekhar; Laitinen, Pia; Väänänen, Mari-Anna; Korvenlaita, Nea; Malm, Tarja; Turunen, Mikko P; Turunen, Tiia A. 2023. Genes. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Early Alzheimer's disease pathology in human cortex involves transient cell states

Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z. 2023. Cell. 186: 4438-4453.e23 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M. 2023. Science of the total environment. 905: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2023. Scientific reports. 13: . 22118 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Liu, Jie; van Beusekom, Heleen; Bu, Xian‐Le; Chen, Gong; Henrique Rosado de Castro, Paulo; Chen, Xiaochun; Chen, Xiaowei; Clarkson, Andrew N.; Farr, Tracy D.; Fu, Yuhong; Jia, Jianping; Jolkkonen, Jukka; Kim, Woojin Scott; Korhonen, Paula; Li, Shen; Liang, Yajie; Liu, Guang‐Hui; Liu, Guiyou; Liu, Yu‐Hui; Malm, Tarja; Mao, Xiaobo; Oliveira, Joaquim Miguel; Modo, Mike M.; Ramos‐Cabrer, Pedro; Ruscher, Karsten; Song, Weihong; Wang, Jun; Wang, Xuanyue; Wang, Yun; Wu, Haitao; Xiong, Lize; Yang, Yi; Y. 2023. Neuroprotection. 1: 84-98 B1 Kirjoitus tieteellisessä aikakauslehdessä

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita. 2023. Embo reports. 24: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

Saveleva, Liudmila; Sima, Michal; Klema, Jiri; Krejčík, Zdeněk; Vartiainen, Petra; Sitnikova, Valeriia; Belaya, Irina; Malm, Tarja; Jalava, Pasi I; Rössner, Pavel; Kanninen, Katja M. 2023. Environmental toxicology and pharmacology. 104: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice

Krivoshein, Georgii; Bakreen, Abdulhameed; van den Maagdenberg, Arn MJM; Malm, Tarja; Giniatullin, Rashid; Jolkkonen, Jukka. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M. 2022. Environmental toxicology and pharmacology. 96: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice

Välimäki, Nelli-Noora; Bakreen, Abdulhameed; Häkli, Sara; Dhungana, Hiramani; Keuters, Meike H; Dunlop, Yannick; Koskuvi, Marja; Keksa-Goldsteine, Velta; Oksanen, Minna; Jäntti, Henna; Lehtonen, Šárka; Malm, Tarja; Koistinaho, Jari; Jolkkonen, Jukka. 2022. Stroke. 53: 3192-3201 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Garcia, Gonçalo; Pinto, Sara; Ferreira, Sofia; Lopes, Daniela; Serrador, Maria João; Fernandes, Adelaide; Vaz, Ana Rita; Mendonça, Alexandre de; Edenhofer, Frank; Malm, Tarja; Koistinaho, Jari; Brites, Dora. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations

Sturchio, Andrea; Dwivedi, Alok K; Malm, Tarja; Wood, Matthew JA; Cilia, Roberto; Sharma, Jennifer S; Hill, Emily J; Schneider, Lon S; Graff-Radford, Neill R; Mori, Hiroshi; Nübling, Georg; El Andaloussi, Samir; Svenningsson, Per; Ezzat, Kariem; Espay, Alberto J; the Dominantly Inherited Alzheimer Consortia (DIAN). 2022. Journal of Alzheimer's disease. 90: 333-348 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna. 2022. Journal of biological chemistry. 298: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Laitinen, Pia; Väänänen, Mari-Anna; Kolari, Ida-Liisa; Mäkinen, Petri I.; Kaikkonen, Minna U.; Weinberg, Marc S.; Morris, Kevin V.; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Roberts, Thomas C.; Turunen, Mikko P.; Turunen, Tiia A.. 2022. PLoS ONE. 17: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Ugidos, Irene F; Pistono, Cristiana; Korhonen, Paula; Gómez-Budia, Mireia; Sitnikova, Valeriia; Klecki, Pamela; Stanová, Iveta; Jolkkonen, Jukka; Malm, Tarja. 2022. Stroke. 53: 1500-1509 A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M. 2022. Neurotoxicology. 89: 55-66 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel PF; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco HS; Jalava, Pasi I. 2022. International journal of environmental research and public health. 19: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The State of the Art of Piezo1 Channels in Skeletal Muscle Regeneration

Bernareggi, Annalisa; Bosutti, Alessandra; Massaria, Gabriele; Giniatullin, Rashid; Malm, Tarja; Sciancalepore, Marina; Lorenzon, Paola. 2022. International journal of molecular sciences. 23: A2 Katsausartikkeli tieteellisessä aikakauslehdessä

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception

Mikhailov, Nikita; Virenque, Anaïs; Koroleva, Kseniia; Eme-Scolan, Elisa; Teleman, Matei; Abdollahzadeh, Ali; Giniatullina, Raisa; Gafurov, Oleg; Krivoshein, Georgii; Malm, Tarja; Hämäläinen, Riikka H; Sierra, Alejandra; Tohka, Jussi; Rua, Rejane; Noe, Francesco M; Giniatullin, Rashid. 2022. Scientific reports. 12: . 8804 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation

Bosutti, Alessandra; Giniatullin, Arthur; Odnoshivkina, Yulia; Giudice, Luca; Malm, Tarja; Sciancalepore, Marina; Giniatullin, Rashid; D'Andrea, Paola; Lorenzon, Paola; Bernareggi, Annalisa. 2021. Acta physiologica

Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats

Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. 2021. International journal of molecular sciences

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Duodecim

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. Scientific reports

Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

Jonavice, Ugne; Romenskaja, Diana; Kriauciunaite, Karolina; Jarmalaviciute, Akvile; Pajarskiene, Justina; Ka¨eta, Vytautas; Tunaitis, Virginijus; Malm, Tarja; Giniatulin, Rashid; Pivoriunas, Augustas. 2021. International journal of molecular sciences

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja. 2021. Cells

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Pistono, Cristiana; Bister, Nea; Stanová, Iveta; Malm, Tarja. 2021. Frontiers in cell and developmental biology

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Sturchio, Andrea; Dwivedi, Alok K.; Young, Christina B.; Malm, Tarja; Marsili, Luca; Sharma, Jennifer S.; Mahajan, Abhimanyu; Hill, Emily J.; Andaloussi, Samir EL; Poston, Kathleen L.; Manfredsson, Fredric P.; Schneider, Lon S.; Ezzat, Kariem; Espay, Alberto J.. 2021. EClinicalMedicine

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Scientific reports

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

Wurm, Johannes; Konttinen, Henna; Andressen, Christian; Malm, Tarja; Spittau, Björn. 2021. International journal of molecular sciences

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja. 2021. Cells

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. 2021. International journal of molecular sciences

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Heiskanen, Marja A; Honkala, Sanna M; Hentilä, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzen, Martin S; Saunavaara, Virva; Saunavaara, Jani; Helmio, Mika; Löyttyniemi, Eliisa; Nummenmaa, Lauri; Collado, Maria C; Malm, Tarja; Lahti, Leo; Pietiläinen, Kirsi H; Kaprio, Jaakko; Rinne, Juha O; Hannukainen, Jarna C. 2021. BMC sports science, medicine & rehabilitation

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring

Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology

Malmberg, Maja; Malm, Tarja; Gustafsson, Oskar; Sturchio, Andrea; Graff, Caroline; Espay, Alberto J; Wright, Anthony P; El Andaloussi, Samir; Lindén, Anders; Ezzat, Kariem. 2020. Frontiers in neuroscience

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Nurkhametova, Dilyara; Siniavin, Andrei; Streltsova, Maria; Kudryavtsev, Denis; Kudryavtsev, Igor; Giniatullina, Raisa; Tsetlin, Victor; Malm, Tarja; Giniatullin, Rashid. 2020. Frontiers in cellular neuroscience

Editorial: Air Pollution and Brain Health

White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. 2020. Neurochemistry international

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Neurochemistry international

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. 2020. Journal of extracellular vesicles

Impairment of mitochondrial function by particulate matter: Implications for the brain

Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Neurochemistry international

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Journal of neuroinflammation

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Aging cell

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Particle and fibre toxicology

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R; Wojciechowski, Sara; Tore, Fatma; Rizvanov, Albert; Koistinaho, Jari; Malm, Tarja; Giniatullin, Rashid. 2019. Frontiers in cellular neuroscience

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. 2019. Scientific reports

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. IBRO reports

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Human molecular genetics

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Neuropharmacology

Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain

Koroleva, Ksenia; Gafurov, Oleg; Guselnikova, Valeriia; Nurkhametovez, Dilyara; Giniatullina, Raisa; Sitdikova, Guzel; Mattila, Olli S; Lindsberg, Perttu J; Malm, Tarja Maarit; Giniatullin, Rashid. 2019. Frontiers in cellular neuroscience

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. Stem cell reports

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H. 2019. Neurotherapeutics

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Journal of neurology

The viral protein corona directs viral pathogenesis and amyloid aggregation

Ezzat, K; Pernemalm, M; Pålsson, S; Roberts, TC; Järver, P; Dondalska, A; Bestas, B; Sobkowiak, MJ; Levänen, B; Sköld, M; Thompson, EA; Saher, O; Kari, OK; Lajunen, T; Sverremark Ekström, E; Nilsson, C; Ishchenko, Y; Malm, T; Wood, MJA; Power, UF; et al.. 2019. Nature communications

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Korhonen, Paula; Malm, Tarja; White, Anthony R. 2018. Neurochemistry international

8th Kuopio Alzheimer Symposium From translational research to biomarkers, treatment and prevention strategies

Malm, Tarja; Trevisan, Davide. 2018. Publications of the University of Eastern Finland. Reports and studies in health sciences

CuII(atsm) Attenuates Neuroinflammation

Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. Frontiers in neuroscience

Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects

Nuglozeh, Edem; Feroze Fazaludeen, Mohammad; Hasona, Nabil; Malm, Tarja; Mayor, Luisito B; Al-Hazmi, Awdah; Ashankyty, Ibraheem. 2018. Indian Journal of Clinical Biochemistry

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity

Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes

Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M. 2018. InTech Open

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia

Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine

Nurkhametova, Dilyara; Kudryavtsev, Igor; Khayrutdinova, Olga; Serebryakova, Maria; Altunbaev, Rashid; Malm, Tarja; Giniatullin, Rashid. 2018. Frontiers in cellular neuroscience

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. 2018. Frontiers in neuroscience

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. 2017. Journal of medicinal chemistry

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Pharmaceutical research

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Epilepsy research

Lack of collagen XV is protective after ischemic stroke in mice

Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Cell death and disease

Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder

Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Disease models and mechanisms

Metals and lysosomal storage disorders

Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. 2017. Academic press

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE. 2017. Scientific reports

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's diseasethe emerging role for microglia?

Piirainen S, Youssef A, Song C, Kalueff AV, Landreth GE, Malm T, Tian L. 2017. Neuroscience and biobehavioral reviews

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Scientific reports

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Journal of neuroinflammation

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. Neurotherapeutics

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Glia

Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment

Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2016. Frontiers in cellular neuroscience

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Scientific reports

Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto

Kanninen K, Malm T. 2016. Duodecim

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration

Exosomes in Alzheimer's disease

Malm Tarja, Loppi Sanna, Kanninen Katja M. 2016. Neurochemistry international

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets

Grubman Alexandra, Kanninen Katja M, Malm Tarja. 2016. Journal of molecular neuroscience

Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling

Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R. 2016. Cephalalgia

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Journal of neuroinflammation

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

Maysami Samaneh, Wong Raymond, Pradillo Jesus M, Denes Adam, Dhungana Hiramani, Malm Tarja, Koistinaho Jari, Orset Cyrille, Rahman Mahbubur, Rubio Marina, Schwaninger Markus, Vivien Denis, Bath Philip M, Rothwell Nancy J, Allan Stuart M. 2015. Journal of cerebral blood flow and metabolism

Activation of the nuclear receptor PPARdelta is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation

Malm Tarja, Mariani Monica, Donovan Lauren J, Neilson Lee, Landreth Gary E. 2015. Journal of neuroinflammation

Applications of the Keap1-Nrf2 system for gene and cell therapy

Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Free radical biology and medicine

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease

Exosomes as new diagnostic tools in CNS diseases

Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Biochimica et biophysica acta: molecular basis of disease

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Brain behavior and immunity

Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease

Savage Julie C, Jay Taylor, Goduni Elanda, Quigley Caitlin, Mariani Monica M, Malm Tarja, Ransohoff Richard M, Lamb Bruce T, Landreth Gary E. 2015. Journal of neuroscience

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Brain behavior and immunity

Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity

Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Stem cells

Nuclear receptors in neurodegenerative diseases

Skerrett R, Malm T, Landreth G. 2014. Neurobiology of disease

Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin

Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari. 2014. Aging and disease

The Evolving Biology of Microglia in Alzheimer's Disease

Malm Tarja M, Jay Taylor R, Landreth Gary E. 2014. Neurotherapeutics

Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury

Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J. 2014. Cell transplantation

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J. 2013. Aging cell

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Neurobiology of disease

Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?

Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Antioxidants and redox signaling

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. 2013. Journal of neuroinflammation

Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance

Malm T, Magga J, Koistinaho J. 2012. Current translational geriatrics and experimental gerontology reports

Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells

Kärkkäinen V, Magga J, Koistinaho J, Malm T. 2012. Current alzheimer research

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease

Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. 2012. Journal of neuroinflammation

Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease

Magga J, Savchenko E, Malm T, Rolova T, Pollari E, Valonen P, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J. 2012. Journal of cellular and molecular medicine

Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production

Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. 2012. Human molecular genetics

Glycogen synthase kinase-3&#946 : a mediator of inflammation in Alzheimer's disease?

Koistinaho J, Malm T, Goldsteins G. 2011. International journal of alzheimers disease

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis

Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Journal of neuroinflammation

Targeting Glycogen Synthase Kinase-3&#946 for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway

Kanninen K, White AR, Koistinaho J, Malm T. 2011. International journal of alzheimers disease

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications

Malm T, Koistinaho J, Kanninen K. 2011. International journal of alzheimers disease

The role and therapeutic potential of monocytic cells in Alzheimer's disease

Malm T, Koistinaho M, Muona A, Magga J & Koistinaho J. 2010. Glia

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Proceedings of the National Academy of Sciences of the United States of America

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Journal of neurochemistry

Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210

Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. 2008. Febs letters

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience

Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease

Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M. 2008. Glia

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience

Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis

Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Molecular pharmacology

Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits

Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Proceedings of the National Academy of Sciences of the United States of America

Glial Cells in Alzheimer's Disease Models

Malm T. 2006. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Journal of gene medicine

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J. 2005. Neurobiology of disease

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J. 2005. Journal of cerebral blood flow and metabolism

Tarkenna hakuasi

Tutkimusryhmät

Projektit

Avainsanat

Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI

Emerging Models to Study Human Microglia In vitro

Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI

SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location

Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Early Alzheimer's disease pathology in human cortex involves transient cell states

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Microglia states and nomenclature: A field at its crossroads

Microglial amyloid beta clearance is driven by PIEZO1 channels

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

The State of the Art of Piezo1 Channels in Skeletal Muscle Regeneration

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception

"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation

Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Editorial: Air Pollution and Brain Health

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

Impairment of mitochondrial function by particulate matter: Implications for the brain

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice