Annakaisa Haapasalon ryhmä (Molekulaarinen neurodegeneraatio)

Julkaisut

• Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells Leskelä, Stina; Huber, Nadine; Hoffmann, Dorit; Rostalski, Hannah; Remes, Anne M; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa. 2021. Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells Biochimica et biophysica acta: molecular cell research 1868 7: 119021. 2021
• FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. 2021. FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 Molecular neurobiology [Epub ahead of print 30 July 2021]: 1-2. 2021
• GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. 2021. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Journal of neurology neurosurgery and psychiatry [Epub ahead of print 29 June 2021]: 1 - 8. 2021
• State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm Solje, Eino; Benussi, Alberto; Buratti, Emanuele; Remes, Anne M; Haapasalo, Annakaisa; Borroni, Barbara. 2021. State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm Diagnostics 11 5: 788. 2021
• BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Rostalski, Hannah; Hietanen, Tomi; Leskelä, Stina; Behánová, Andrea; Abdollahzadeh, Ali; Wittrahm, Rebekka; Mäkinen, Petra; Huber, Nadine; Hoffmann, Dorit; Solje, Eino; Remes, Anne M; Natunen, Teemu; Takalo, Mari; Tohka, Jussi; Hiltunen, Mikko; Haapasalo, Annakaisa. 2020. BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Frontiers in neurology 11: 550140. 2020
• C9orf72 Repeat Expansion Does Not Affect the Phenotype in Primary Progressive Aphasia Haapanen, Marjut; Katisko, Kasper; Hänninen, Tuomo; Krüger, Johanna; Hartikainen, Päivi; Haapasalo, Annakaisa; Remes, Anne M; Solje, Eino. 2020. C9orf72 Repeat Expansion Does Not Affect the Phenotype in Primary Progressive Aphasia Journal of Alzheimer's disease 78 3: 919-925. 2020
• Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease Korhonen, Titta; Katisko, Kasper; Cajanus, Antti; Hartikainen, Päivi; Koivisto, Anne M; Haapasalo, Annakaisa; Remes, Anne M; Solje, Eino. 2020. Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease Dementia and geriatric cognitive disorders 49 1: 98-106. 2020
• Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. 2020. Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques Molecular neurodegeneration 15: 66. 2020
• Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium Hoffmann, Dorit; Huber, Nadine; Leskelä, Stina; Rostalski, Hannah; Solje, Eino; Remes, Anne M; Haapasalo, Annakaisa. 2020. Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium Neurodegenerative disease management 10 3: 1758-2024. 2020
• Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia Luukkainen, L; Huttula, S; Väyrynen, H; Helisalmi, S; Kytövuori, L; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2020. Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia Journal of Alzheimer's disease 76 3: 955-965. 2020
• Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß Cells 9 11: 2482. 2020
• Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis Cajanus, Antti; Katisko, Kasper; Kontkanen, Aleksi; Jääskeläinen, Olli; Hartikainen, Päivi; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Vanninen, Ritva; Solje, Eino; Hall, Anette; Remes, Anne. 2020. Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis Annals of clinical and translational neurology 7 6: 903-910. 2020
• The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions Takalo, Mari; Wittrahm, Rebekka; Wefers, Benedikt; Parhizkar, Samira; Jokivarsi, Kimmo; Kuulasmaa, Teemu; Mäkinen, Petra; Martiskainen, Henna; Wurst, Wolfgang; Xiang, Xianyuan; Marttinen, Mikael; Poutiainen, Pekka; Haapasalo, Annakaisa; Hiltunen, Mikko; Haass, Christian. 2020. The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions Molecular neurodegeneration 15 1: 52. 2020
• Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Rostalski, Hannah; Leskelä, Stina; Huber, Nadine; Katisko, Kasper; Cajanus, Antti; Solje, Eino; Marttinen, Mikael; Natunen, Teemu; Remes, Anne M; Hiltunen, Mikko; Haapasalo, Annakaisa. 2019. Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Frontiers in neuroscience 13: 486. 2019
• C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner Leskelä, S; Huber, N; Rostalski, H; Natunen, T; Remes, AM; Takalo, M; Hiltunen, M; Haapasalo, A. 2019. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner Cells 8 10: 1233. 2019
• Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Kunkle, BW; Grenier-Boley, B; Sims, R; Bis, JC; Damotte, V; Naj, AC; Boland, A; Vronskaya, M; van der Lee, S; Amlie-Wolf, A; Bellenguez, C; Frizatti, A; Chouraki, V; Martin, ER; Sleegers, K; Badarinarayan, N; Jakobsdottir, J; Hamilton-Nelson, KL; Moreno-Grau, S; Olaso R; et al. (Incl. Hiltunen, Mikko; Haapasalo; Annakaisa; Helisalmi, Seppo; Koivisto, Anne; Soininen, Hilkka). 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nature genetics 51 3: 414-430. 2019
• Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Journal of Alzheimer's disease 72 1: 127-137. 2019
• Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2019. Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 69 3: 775-782. 2019
• PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia Stem cell reports 13 4: 669-683. 2019
• Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion Journal of neurology 2020; 267: 76-86. 2019
• Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Dementia and geriatric cognitive disorders 47 1-2: 91-103. 2019
• Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers Katisko, Kasper; Cajanus, Antti; Korhonen, Titta; Remes, Anne M; Haapasalo, Annakaisa; Solje, Eino. 2019. Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers Frontiers in neuroscience 13: 658. 2019
• Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders Katisko, K; Cajanus, A; Jääskeläinen, O; Kontkanen, A; Hartikainen, P; Korhonen, VE; Helisalmi, S; Haapasalo, A; Koivumaa-Honkanen, H; Herukka, SK; Remes, AM; Solje, E. 2019. Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders Journal of neurology 2020; 267 1: 162-167. 2019
• A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology Marttinen, M; Paananen, J; Neme, A; Mitra, V; Takalo, M; Natunen, T; Paldanius, KMA; Mäkinen, P; Bremang, M; Kurki, MI; Rauramaa, T; Leinonen, V; Soininen, H; Haapasalo, A; Pike, I; Hiltunen, M. 2018. A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology Neurobiology of disease 2019; 124: 454-468. 2018
• A report from the 8th Kuopio Alzheimer Symposium Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. A report from the 8th Kuopio Alzheimer Symposium Neurodegenerative disease management 8 5: 289-299. 2018
• Decreased plasma C-reactive protein levels in APOE E 4 allele carriers Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Decreased plasma C-reactive protein levels in APOE E 4 allele carriers Annals of Clinical and Translational Neurology 5 10: 1229-1240. 2018
• Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples Journal of Alzheimer's disease 62 1: 269-278. 2018
• Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino. 2018. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 62 2: 789-794. 2018
• Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease Frontiers in neurology 12: 963. 2018
• Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers JOURNAL OF NEUROIMMUNOLOGY 321: 29-35. 2018
• The association between frontotemporal lobar degeneration and bullous pemphigoid Katisko, Kasper; Kokkonen, Nina; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Helisalmi, Seppo; Korhonen, Ville; Kokki, Merja; Tuusa, Jussi; Herukka, Sanna-Kaisa; Solje, Eino; Haapasalo, Annakaisa; Tasanen, Kaisa; Remes, Anne. 2018. The association between frontotemporal lobar degeneration and bullous pemphigoid Journal of Alzheimer's disease 66 2: 743-750. 2018
• PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9 6: 1885-1897. 2017
• Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADG. 2017. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. NATURE GENETICS 49 9: 1373-1384. 2017
• Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's Disease 2017; 55 3: 995-1003. 2016
• SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1 Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. JOURNAL OF CELL SCIENCE 129: 2224-2238. 2016
• Synaptic dysfunction and septin protein family members in neurodegenerative diseases Marttinen Mikael, Kurkinen Kaisa MA, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Synaptic dysfunction and septin protein family members in neurodegenerative diseases. MOLECULAR NEURODEGENERATION 10 16: 12 p. 2015
• Genetic and Molecular Aspects of Frontotemporal Lobar Degeneration Haapasalo Annakaisa, Remes Anne M. 2014. Genetic and Molecular Aspects of Frontotemporal Lobar Degeneration. Current Genetic Medicine Reports 2015; 3 1: 8-18. 2014
• Protein aggregation and degradation mechanisms in neurodegenerative diseases Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A. 2013. Protein aggregation and degradation mechanisms in neurodegenerative diseases. American Journal of Neurodegenerative Disease 2 1: 1-14. 2013