Epilepsy Research

Julkaisut

• Biomarkers for posttraumatic epilepsy Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Biomarkers for posttraumatic epilepsy Epilepsy and behavior 121 Part B: 107080. 2021
• A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis. Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W / 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). 2020. 2020
• Biomarkers For Epileptogenesis And Its Treatment Engel, Jerome Jr; Pitkänen, Asla. 2020. Biomarkers For Epileptogenesis And Its Treatment Neuropharmacology 167: 107735. 2020
• Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI International journal of molecular sciences 21 7: 2418. 2020
• Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization Scientific reports 10: 9012. 2020
• Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury Journal of neurotrauma 37 23: 2580-2594. 2020
• Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury Neuroscience 433: 21-35. 2020
• Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation Brain pathology 30 5: 897-912. 2020
• Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala Ryazantseva, Maria; Englund, Jonas; Shintyapina, Alexandra; Huupponen, Johanna; Shteinikov, Vasilii; Pitkänen, Asla; Partanen, Juha; Lauri, Sari. 2020. Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala eLife 9: e52798. 2020
• Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury Neurobiology of disease 145: 1-20. 2020
• Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla. 2020. Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury Neuroscience letters 729: 134935. 2020
• Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats Epilepsia 61 9: 2035-2052. 2020
• The role of the platelet-derived growth factor receptor B and the urokinase-type plasminogen activator receptor in brain injury pathology Kyyriäinen, Jenni (ed.) . 2020. The role of the platelet-derived growth factor receptor B and the urokinase-type plasminogen activator receptor in brain injury pathology. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Health Sciences 582. 2020
• Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury Journal of neurotrauma 2020; 37 7: 924-938. 2019
• Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla. 2019. Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats Journal of neurotrauma 36 11: 1890-1907. 2019
• Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla. 2019. Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats Journal of neurotrauma 36 11: 1890-1907. 2019
• Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy Pitkänen, A; Henshall, DC; Cross, JH; Guerrini, R; Jozwiak, S; Kokaia, M; Simonato, M; Sisodiya, S; Mifsud, J. 2019. Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy Epilepsia 60 7: 1281-1292. 2019
• Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force Harte-Hargrove, Lauren C; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E. 2019. Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force Epilepsia open 3 S1: 13-23. 2019
• Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility Epilepsy research 151: 67-74. 2019
• Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility Epilepsy research 151: 67-74. 2019
• Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury Scientific reports 9: 20208. 2019
• Epilepsy biomarkers - Toward etiology and pathology specificity Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Epilepsy biomarkers - Toward etiology and pathology specificity Neurobiology of disease 123: 42-58. 2019
• Epilepsy biomarkers - Toward etiology and pathology specificity Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Epilepsy biomarkers - Toward etiology and pathology specificity Neurobiology of disease 123: 42-58. 2019
• Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A. 2019. Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies International journal of molecular sciences 20 6: 1259. 2019
• Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A. 2019. Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies International journal of molecular sciences 20 6: 1259. 2019
• Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2) Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2) Neuroscience 415: 184-200. 2019
• Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research 151: 7-16. 2019
• Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research 151: 7-16. 2019
• Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106110. 2019
• Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research 150: 46-57. 2019
• Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research 150: 46-57. 2019
• Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106131. 2019
• In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned International journal of molecular sciences 20 21: 5395. 2019
• Lateral fluid-percussion injury leads to pituitary atrophy in rats Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Lateral fluid-percussion injury leads to pituitary atrophy in rats Scientific reports 9 1: 11819. 2019
• MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study Frontiers in neuroscience 13: 863. 2019
• Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative Scharfman, Helen E; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Harte-Hargrove, Lauren C. 2019. Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative Epilepsia open 3: 9-12. 2019
• Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Pitkänen, Asla; O'Brien, Terence J; Staba, Richard. 2019. Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Epilepsy research 156: 1-4. 2019
• Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Pitkänen, Asla; O'Brien, Terence J; Staba, Richard. 2019. Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Epilepsy research 156: 1-4. 2019
• Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury Schweser, F; Kyyriäinen, J; Preda, M; Pitkänen, A; Toffolo, K; Poulsen, A; Donahue, K; Levy, B; Poulsen, D. 2019. Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury Neuroimage 200: 250-258. 2019
• Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice Ciszek, R; Andrade, P; Tapiala, J; Pitkänen, A; Ndode-Ekane, XE. 2019. Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice Neuroinformatics 2020; 18: 307-317. 2019
• A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle. 2018. A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats JOURNAL OF NEUROSCIENCE METHODS 308: 330-336. 2018
• A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle. 2018. A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats JOURNAL OF NEUROSCIENCE METHODS 308: 330-336. 2018
• Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird Soulsbury, Carl D; Lipponen, Anssi; Wood, Kristie; Mein, Charles A; Hoffman, Joseph I; Lebigre, Christophe. 2018. Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird Ecology and Evolution 8 13: 6547-6557. 2018
• Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla. 2018. Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy JOURNAL OF NEUROSCIENCE METHODS 307: 37-45. 2018
• Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla. 2018. Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy JOURNAL OF NEUROSCIENCE METHODS 307: 37-45. 2018
• Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients Duncan, Dominique; Barisano, Giuseppe; Cabeen, Ryan; Sepehrband, Farshid; Garner, Rachael; Braimah, Adebayo; Vespa, Paul; Pitkänen, Asla; Law, Meng; Toga, Arthur W. 2018. Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients Frontiers in Neuroscience 12: 86. 2018
• Big data sharing and analysis to advance research in post-traumatic epilepsy Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W. 2018. Big data sharing and analysis to advance research in post-traumatic epilepsy Neurobiology of disease 2019; 123: 127-136. 2018
• Big data sharing and analysis to advance research in post-traumatic epilepsy Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W. 2018. Big data sharing and analysis to advance research in post-traumatic epilepsy Neurobiology of disease 2019; 123: 127-136. 2018
• Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Journal of neurotrauma 35 22: 2708-2717. 2018
• Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Journal of neurotrauma 35 22: 2708-2717. 2018
• Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study Tubi, MA; Lutkenhoff, E; Blanco, MB; McArthur, D; Villablanca, P; Ellingson, B; Diaz-Arrastia, R; Van Ness, P; Real, C; Shrestha, V; Engel, J; Jr; Vespa, PM; Agoston, D; Au, A; Bell, MJ; Bleck, T; Branch, C; Buitrago Blanco, M; Bullock, R; Burrows, BT; et al.; EpiBioS4Rx Study Group Investigators (incl. Pitkänen, Asla). 2018. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study Neurobiology of disease 2019; 123: 115-121. 2018
• Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen Pulkkinen, Katja; Pekkala, Nina; Ashrafi, Roghaieh; Hämäläinen, Dorrit M; Nkembeng, Aloysius N; Lipponen, Anssi; Hiltunen, Teppo; Valkonen, Janne K; Taskinen, Jouni. 2018. Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen Fems microbiology ecology 94 5: fiy060. 2018
• Epilepsy in neuropathologically verified Alzheimer's disease Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Epilepsy in neuropathologically verified Alzheimer's disease. SEIZURE 58: 9-12. 2018
• Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 149: 92-101. 2018
• Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 149: 92-101. 2018
• Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 150: 17-26. 2018
• Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 150: 17-26. 2018
• Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018
• Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018
• Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018
• Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018
• T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla. 2018. T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury RESTORATIVE NEUROLOGY AND NEUROSCIENCE 36 4: 485-501. 2018
• T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla. 2018. T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury RESTORATIVE NEUROLOGY AND NEUROSCIENCE 36 4: 485-501. 2018
• Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury. Acta neuropathologica communications 6: 17. 2018
• miR-124-3p is a chronic regulator of gene expression after brain injury Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. miR-124-3p is a chronic regulator of gene expression after brain injury Cellular and molecular life sciences 75 24: 4557-4581. 2018
• miR-124-3p is a chronic regulator of gene expression after brain injury Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. miR-124-3p is a chronic regulator of gene expression after brain injury Cellular and molecular life sciences 75 24: 4557-4581. 2018