Kuljetusproteiinit sairauksissa

Transporters in Diseases Lab focuses on exploring the roles of membrane transporters, such as solute carriers (SLCs) and ATP-binding cassette (ABCs) transporters and receptors expressed at barrier sites in the pathogenesis of diseases. Our particular aim is to unravel the contribution of membrane transporters in the development and progression of Alzheimer’s disease (AD) to develop new therapeutic approaches for AD targeting transporter-mediated pathways. Another aim of our Lab is to identify changes in the functional expression of transporters in disease states with related potential alterations in drug delivery and pharmacokinetics.  Furthermore, in our Lab, we characterize different in vitro and in vivo animal models for studying the blood-brain barrier and membrane transporters/receptors in pathological conditions to provide information about their relevance to mimic human diseases.