Otsalohkodementiatutkimuksen verkosto (FinFTD)

Julkaisut

• A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A. 2021. A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population Journal of Alzheimer's disease 83 3: 1325-1332. 2021
• C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction Huber, Nadine; Hoffmann, Dorit; Giniatullina, Raisa; Rostalski, Hannah; Leskelä, Stina; Takalo, Mari; Natunen, Teemu; Solje, Eino; Remes, Anne M.; Giniatullin, Rashid; Hiltunen, Mikko; Haapasalo, Annakaisa. 2021. C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction Neurobiology of disease 2022; 162: 105584. 2021
• Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches Huber, Nadine; Korhonen, Sonja; Hoffmann, Dorit; Leskelä, Stina; Rostalski, Hannah; Remes, Anne M.; Honkakoski, Paavo; Solje, Eino; Haapasalo, Annakaisa. 2021. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches Molecular psychiatry Published online: 19 November 2021: 1 - 10. 2021
• Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration Giunta, Marcello; Solje, Eino; Gardoni, Fabrizio; Borroni, Barbara; Benussi, Alberto. 2021. Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration Journal of Experimental Pharmacology 13: 359-376. 2021
• Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells Leskelä, Stina; Huber, Nadine; Hoffmann, Dorit; Rostalski, Hannah; Remes, Anne M; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa. 2021. Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells Biochimica et biophysica acta: molecular cell research 1868 7: 119021. 2021
• FRONTotemporal dementia Incidence European Research Study - FRONTIERS: Rationale and design Borroni, Barbara; Graff, Caroline; Hardiman, Orla; Ludolph, Albert C; Moreno, Fermin; Otto, Markus; Piccininni, Marco; Remes, Anne M; Rowe, James B; Seelaar, Harro; Stefanova, Elka; Traykov, Latchezar; Logroscino, Giancarlo; Alberici, Antonella; Anderl-Straub, Sarah; Barandiaran, Myriam; Belezhanska, Diyana; Benussi, Alberto; Bianchetti, Angelo; Capozzo, Rosa; FRONTIERS [incl. Solje, Eino]. 2021. FRONTotemporal dementia Incidence European Research Study - FRONTIERS: Rationale and design Alzheimer's & dementia 2022; 18 3: 498-506. 2021
• FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. 2021. FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 Molecular neurobiology 58 11: 5438-5458. 2021
• GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. 2021. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Journal of neurology neurosurgery and psychiatry 92 12: 1305-1312. 2021
• Otsa-ohimolohkorappeumat Otsa-ohimolohkorappeumat. Solje, Eino; Krüger, Johanna; Suhonen, Noora; Remes, Anne M / Kliininen neuropsykiatria (2. uudistettu painos). 2021. 2021
• Otsa-ohimolohkorappeumat - miten tunnistan ja hoidan? Krüger, Johanna; Katisko, Kasper; Suhonen, Noora-Maria; Haapasalo, Annakaisa; Remes, Anne M; Solje, Eino. 2021. Otsa-ohimolohkorappeumat - miten tunnistan ja hoidan? Duodecim 137 21: 2307-2316. 2021
• Primary progressive aphasias associated with C9orf72 expansions: Another side of the story Saracino, Dario; Géraudie, Amandine; Remes, Anne M.; Ferrieux, Sophie; Noguès-Lassiaille, Marie; Bottani, Simona; Cipriano, Lorenzo; Houot, Marion; Funkiewiez, Aurélie; Camuzat, Agnès; Rinaldi, Daisy; Teichmann, Marc; Pariente, Jérémie; Couratier, Philippe; Boutoleau-Bretonnière, Claire; Auriacombe, Sophie; Etcharry-Bouyx, Frédérique; Levy, Richard; Migliaccio, Raffaella; Solje, Eino et al. 2021. Primary progressive aphasias associated with C9orf72 expansions: Another side of the story Cortex 145: 145-159. 2021
• Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis Niiranen, Marja; Kontkanen, Aleksi; Jääskeläinen, Olli; Tertsunen, Hanna-Mari; Selander, Tuomas; Hartikainen, Päivi; Huber, Nadine; Solje, Eino; Haapasalo, Annakaisa; Kokkola, Tarja; Lohioja, Tarja; Herukka, Sanna-Kaisa; Simula, Sakari; Remes, Anne M.. 2021. Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis Multiple sclerosis and related disorders 56: 103280. 2021
• State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm Solje, Eino; Benussi, Alberto; Buratti, Emanuele; Remes, Anne M; Haapasalo, Annakaisa; Borroni, Barbara. 2021. State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm Diagnostics 11 5: 788. 2021
• Suuntana muistisairauden yksilöllinen varhaisdiagnostiikka ja hoito Solje, Eino; Remes, Anne M; Krüger, Johanna. 2021. Suuntana muistisairauden yksilöllinen varhaisdiagnostiikka ja hoito Duodecim 137 21: 2223-2225. 2021
• BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Rostalski, Hannah; Hietanen, Tomi; Leskelä, Stina; Behánová, Andrea; Abdollahzadeh, Ali; Wittrahm, Rebekka; Mäkinen, Petra; Huber, Nadine; Hoffmann, Dorit; Solje, Eino; Remes, Anne M; Natunen, Teemu; Takalo, Mari; Tohka, Jussi; Hiltunen, Mikko; Haapasalo, Annakaisa. 2020. BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Frontiers in neurology 11: 550140. 2020
• C9orf72 Repeat Expansion Does Not Affect the Phenotype in Primary Progressive Aphasia Haapanen, Marjut; Katisko, Kasper; Hänninen, Tuomo; Krüger, Johanna; Hartikainen, Päivi; Haapasalo, Annakaisa; Remes, Anne M; Solje, Eino. 2020. C9orf72 Repeat Expansion Does Not Affect the Phenotype in Primary Progressive Aphasia Journal of Alzheimer's disease 78 3: 919-925. 2020
• Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease Korhonen, Titta; Katisko, Kasper; Cajanus, Antti; Hartikainen, Päivi; Koivisto, Anne M; Haapasalo, Annakaisa; Remes, Anne M; Solje, Eino. 2020. Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease Dementia and geriatric cognitive disorders 49 1: 98-106. 2020
• Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium Hoffmann, Dorit; Huber, Nadine; Leskelä, Stina; Rostalski, Hannah; Solje, Eino; Remes, Anne M; Haapasalo, Annakaisa. 2020. Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium Neurodegenerative disease management 10 3: 1758-2024. 2020
• Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia Luukkainen, L; Huttula, S; Väyrynen, H; Helisalmi, S; Kytövuori, L; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2020. Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia Journal of Alzheimer's disease 76 3: 955-965. 2020
• Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis Cajanus, Antti; Katisko, Kasper; Kontkanen, Aleksi; Jääskeläinen, Olli; Hartikainen, Päivi; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Vanninen, Ritva; Solje, Eino; Hall, Anette; Remes, Anne. 2020. Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis Annals of clinical and translational neurology 7 6: 903-910. 2020
• The ethical implications of genetic testing in neurodegenerative diseases: A systematic review Nurmi, Sanna-Maria; Halkoaho, Arja; Moilanen, Jukka; Remes, Anne M; Solje, Eino. 2020. The ethical implications of genetic testing in neurodegenerative diseases: A systematic review Scandinavian journal of caring sciences 2021; 35 4: 1057-1074. 2020
• Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Rostalski, Hannah; Leskelä, Stina; Huber, Nadine; Katisko, Kasper; Cajanus, Antti; Solje, Eino; Marttinen, Mikael; Natunen, Teemu; Remes, Anne M; Hiltunen, Mikko; Haapasalo, Annakaisa. 2019. Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Frontiers in neuroscience 13: 486. 2019
• C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner Leskelä, S; Huber, N; Rostalski, H; Natunen, T; Remes, AM; Takalo, M; Hiltunen, M; Haapasalo, A. 2019. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner Cells 8 10: 1233. 2019
• Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Journal of Alzheimer's disease 72 1: 127-137. 2019
• Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2019. Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 69 3: 775-782. 2019
• Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion Journal of neurology 2020; 267: 76-86. 2019
• Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Dementia and geriatric cognitive disorders 47 1-2: 91-103. 2019
• Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers Katisko, Kasper; Cajanus, Antti; Korhonen, Titta; Remes, Anne M; Haapasalo, Annakaisa; Solje, Eino. 2019. Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers Frontiers in neuroscience 13: 658. 2019
• Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders Katisko, K; Cajanus, A; Jääskeläinen, O; Kontkanen, A; Hartikainen, P; Korhonen, VE; Helisalmi, S; Haapasalo, A; Koivumaa-Honkanen, H; Herukka, SK; Remes, AM; Solje, E. 2019. Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders Journal of neurology 2020; 267 1: 162-167. 2019
• The Association Between Distinct Frontal Brain Volumes and Behavioral Symptoms in Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia Cajanus, A; Solje, E; Koikkalainen, J; Lötjönen, J; Suhonen, NM; Hallikainen, I; Vanninen, R; Hartikainen, P; de Marco, M; Venneri, A; Soininen, H; Remes, AM; Hall, A. 2019. The Association Between Distinct Frontal Brain Volumes and Behavioral Symptoms in Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia Frontiers in neurology 10: 1059. 2019
• Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis Cajanus, A; Hall, A; Koikkalainen, J; Solje, E; Tolonen, A; Urhemaa, T; Liu, Y; Haanpää, RM; Hartikainen, P; Helisalmi, S; Korhonen, V; Rueckert, D; Hasselbalch, S; Waldemar, G; Mecocci, P; Vanninen, R; van Gils, M; Soininen, H; Lötjönen, J; Remes, AM. 2018. Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis Dementia and geriatric cognitive disorders extra 8 1: 51-59. 2018
• Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples Journal of Alzheimer's disease 62 1: 269-278. 2018
• Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino. 2018. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 62 2: 789-794. 2018
• Otsalohkodementia - neurologian ja psykiatrian rajapinnalla Solje, Eino; Remes, Anne M. 2018. Otsalohkodementia - neurologian ja psykiatrian rajapinnalla Lääkärilehti 73 1-2: 9. 2018
• Otsalohkodementia - salakavala muistisairaus Remes, Anne M; Haanpää, Ramona M; Suhonen, Noora-Maria; Junttila, Anna; Solje, Eino. 2018. Otsalohkodementia - salakavala muistisairaus Lääkärilehti 73 1-2: 37-41. 2018
• Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers Journal of neuroimmunology 321: 29-35. 2018
• Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject Haapalinna, F; Kokki, M; Jääskeläinen, O; Hallikainen, M; Helisalmi, S; Koivisto, A; Kokki, H; Paajanen, T; Penttinen, J; Pikkarainen, M; Rautiainen, M; Soininen, H; Solje, E; Remes, AM; Herukka, SK. 2018. Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject Journal of Alzheimer's disease 62 1: 165-174. 2018
• The association between frontotemporal lobar degeneration and bullous pemphigoid Katisko, Kasper; Kokkonen, Nina; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Helisalmi, Seppo; Korhonen, Ville; Kokki, Merja; Tuusa, Jussi; Herukka, Sanna-Kaisa; Solje, Eino; Haapasalo, Annakaisa; Tasanen, Kaisa; Remes, Anne. 2018. The association between frontotemporal lobar degeneration and bullous pemphigoid Journal of Alzheimer's disease 66 2: 743-750. 2018
• Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case Korhonen VE, Solje E, Suhonen NM, Rauramaa T, Vanninen R, Remes AM, Leinonen V. 2017. Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case Fluids and barriers of the cns 14: 10. 2017
• The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966 Solje Eino, Miettunen Jouko, Marttila Riikka, Helisalmi Seppo, Laitinen Marjo, Koivumaa-Honkanen Heli, Isohanni Matti, Hiltunen Mikko, Jääskeläinen Erika, Remes Anne M. 2016. The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966 Psychiatric genetics 26 2: 92-94. 2016
• The Spectrum of the Phenotypes in the C9ORF72 Expansion Carriers: Insights at the Interface between Neurology and Psychiatry Solje Eino. 2016. The Spectrum of the Phenotypes in the C9ORF72 Expansion Carriers: Insights at the Interface between Neurology and Psychiatry. Publications of the University of Eastern Finland. Dissertations in Health Sciences 334. 2016
• The role of the FTD-ALS associated C9orf72 expansion in suicide victims Solje Eino, Riipinen Pirkko, Helisalmi Seppo, Särkioja Terttu, Laitinen Marjo, Hiltunen Mikko, Hakko Helinä, Remes Anne M. 2016. The role of the FTD-ALS associated C9orf72 expansion in suicide victims Amyotrophic lateral sclerosis & frontotemporal degeneration 17 7-8: 589-592. 2016
• The phenotype of the C90RF72 Expansion carriers according to revised crieria for bvFTD Solje Eino, Aaltokallio Heidi, Koivumaa-Honkanen Heli, Suhonen Noora M, Moilanen Virpi, Kiviharju Anna, Traynor Bryan, Tienari Pentti J, Hartikainen Päivi, Remes Anne M. 2015. The phenotype of the C90RF72 Expansion carriers according to revised crieria for bvFTD PLoS ONE 10 7: e0131817. 2015
• Genetic and Molecular Aspects of Frontotemporal Lobar Degeneration Haapasalo Annakaisa, Remes Anne M. 2014. Genetic and Molecular Aspects of Frontotemporal Lobar Degeneration. Current Genetic Medicine Reports 2015; 3 1: 8-18. 2014
• The C90RF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation Solje Eino, Hartikainen Päivi, Valori Miko, Vanninen Ritva, Tiihonen Jari, Hakola Panu, Tienari Pentti J, Remes Anne M. 2014. The C90RF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation Neurobiology of aging 35 7: 1780.e13-1780.e17. 2014