Ali Koskela

Functional polymorphisms in pigmentation-related genes MC1R and DCT display population-specific association with wet age-related macular degeneration

Reinisalo, Mika; Helisalmi, Seppo; Koskela, Ali; Küblbeck, Jenni; Liukkonen, Mikko; Mutikainen, Maija; Cree, Angela J; Griffiths, Helen; Papp, Andras; Seitsonen, Sanna; Immonen, Ilkka; Soininen, Hilkka; Urtti, Arto; Hiltunen, Mikko; Winiarczyk, Mateusz; Resch, Miklos; Ratnayaka, J Arjuna; Lotery, Andrew J.; Karniranta, Kai; Honkakoski, Paavo, 2026, Biochemistry and biophysics reports, 45, 102477. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

Ruuth, Johanna; Tamminen, Toni; Toropainen, Elisa; Tanila, Heikki; Hyttinen, Juha MT; Malm, Tarja; Kaarniranta, Kai; Koskela, Ali, 2026, Faseb journal, 40, 5, e71608. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Sustained intravitreal dissolution and kinase inhibition by an inhibitory cGMP analogue after its injection as a suspension of a poorly soluble salt

Valkama, Eetu; Toropainen, Elisa; Singh, Simar Pal; Valtari, Annika; Koskela, Ali; Merivaara, Arto; Perez, Oswaldo; Ruponen, Marika; Groten, John; Schipper, Nicolaas; Urtti, Arto; Vellonen, Kati-Sisko; Lajunen, Tatu; Puranen, Jooseppi, 2026, Biomedicine and pharmacotherapy, 199, 119387. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rapid elimination of suprachoroidally injected small molecule drugs into the systemic blood circulation

Laitinen, Jonna; Valkama, Eetu; Valtari, Annika; Toropainen, Elisa; Koskela, Ali; Kolehmainen, Ida; Puranen, Jooseppi; del Amo, Eva M.; Vellonen, Kati-Sisko; Subrizi, Astrid; Urtti, Arto, 2025, European journal of pharmaceutical sciences, 215, 107349. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Secretory autophagy and epithelial-to-mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Gurubaran, Iswariyaraja Sridevi; Koskela, Ali; Heloterae, Hanna; Kaarniranta, Kai, 2025, Acta ophthalmologica, 104, 2, 239-251. B1 Kirjoitus tieteellisessä aikakauslehdessä

Autophagy in drusen biogenesis secondary to age-related macular degeneration

Hyttinen, Juha M T; Koskela, Ali; Blasiak, Janusz; Kaarniranta, Kai, 2024, Acta ophthalmologica, 102, 7, 759-772. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Liukkonen, Mikko; Heloterä, Hanna; Siintamo, Leea; Ghimire, Bishwa; Mattila, Pirkko; Kivinen, Niko; Kostanek, Joanna; Watala, Cezary; Hytti, Maria; Hyttinen, Juha; Koskela, Ali; Blasiak, Janusz; Kaarniranta, Kai, 2024, Investigative ophthalmology and visual science, 65, 13, 30. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai, 2023, Journal of biological chemistry, 299, 6, 104770. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Vottonen, Linda; Koskela, Ali; Felszeghy, Szabolcs; Wylegala, Adam; Kryszan, Katarzyna; Gurubaran, Iswariyaraja Sridevi; Kaarniranta, Kai; Wylegala, Edward, 2023, Journal of clinical medicine, 12, 13, 4332. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Koskela, Ali; Manai, Federico; Basagni, Filippo; Liukkonen, Mikko; Rosini, Michela; Govoni, Stefano; Monte, Massimo Dal; Smedowski, Adrian; Kaarniranta, Kai; Amadio, Marialaura, 2022, Antioxidants, 11, 7, 1385. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops

Pacwa, Anna; Machowicz, Joanna; Wojtyniak, Alicja; Pietrucha-Dutczak, Marita; Toropainen, Elisa; Koskela, Ali; Mrukwa-Kominek, Ewa; Lewin-Kowalik, Joanna; Smedowski, Adrian, 2022, Journal of inflammation research, 15, 793-806. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai, 2021, International journal of molecular sciences, 22, 4, 1684. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-ß2 are elevated in a Finnish wet age-related macular degeneration cohort

Liukkonen, Mikko PK; Paterno, Jussi J; Kivinen, Niko; Siintamo, Leea; Koskela, Ali KJ; Kaarniranta, Kai, 2021, Acta ophthalmologica, [Epub ahead of print 26 Oct 2021], 1-10. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali], 2021, Autophagy, 17, 1, 1-382. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto, 2021, Biomedicine and pharmacotherapy, 2022; 146, 112501. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai, 2021, Biology, 10, 7, 622. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Tamminen, Toni; Koskela, Ali; Toropainen, Elisa; Gurubaran, Iswariyaraja Sridevi; Winiarczyk, Mateusz; Liukkonen, Mikko; Paterno, Jussi J; Lackman, Petri; Sadeghi, Amir; Viiri, Johanna; Hyttinen, Juha MT; Koskelainen, Ari; Kaarniranta, Kai, 2021, Oxidative medicine and cellular longevity, 2021, 8028427. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai, 2020, Genes, 11, 11, 1318. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu, 2020, International journal of molecular sciences, 21, 6, 2066. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K, 2019, International journal of molecular sciences, 20, 15, 3773. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J, 2019, Oxidative medicine and cellular longevity, 2019, 9682318. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K, 2019, Journal of cellular and molecular medicine, 23, 12, 8464-8471. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu, 2019, Biochimie, 159, 49-54. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Using online game-based platforms to improve student performance and engagement in histology teaching

Felszeghy, S; Pasonen-Seppänen, S; Koskela, A; Nieminen, P; Härkönen, K; Paldanius, KMA; Gabbouj, S; Ketola, K; Hiltunen, M; Lundin, M; Haapaniemi, T; Sointu, E; Bauman, EB; Gilbert, GE; Morton, D; Mahonen, A, 2019, Bmc medical education, 19, 1, 273. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura, 2018, Oxidative medicine and cellular longevity, 2018, 4956080. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A], 2018, Redox biology, 2019; 20, 1-12. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K, 2017, International journal of molecular sciences, 18, 5, 1089. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai, 2017, Duodecim, 133, 7, 641-646. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Felszeghy Szabolcs, Pasonen-Seppänen Sanna, Koskela Ali, Mahonen Anitta, 2017, MedEd publish, 6, 3, 40. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian, 2016, European journal of pharmacology, 788, 12-20. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai, 2016, Nutrients, 8, 5, 284. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O., 2015, Oxidative medicine and cellular longevity, 2015, Article ID 340520, 24 p.. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O, 2014, Molecular vision, 20, 760-769. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects

Törrönen R, McDougall GJ, Dobson G, Stewart D, Hellström J, Mattila P, Pihlava J-M, Koskela A, Karjalainen R, 2012, Journal of functional foods, 4, 746-756. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tarkenna hakuasi

Tutkimusryhmät

Julkaisut

Functional polymorphisms in pigmentation-related genes MC1R and DCT display population-specific association with wet age-related macular degeneration

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

Sustained intravitreal dissolution and kinase inhibition by an inhibitory cGMP analogue after its injection as a suspension of a poorly soluble salt

Rapid elimination of suprachoroidally injected small molecule drugs into the systemic blood circulation

Secretory autophagy and epithelial-to-mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Autophagy in drusen biogenesis secondary to age-related macular degeneration

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-ß2 are elevated in a Finnish wet age-related macular degeneration cohort

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Using online game-based platforms to improve student performance and engagement in histology teaching

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects