Ali Koskela

Secretory autophagy and epithelial-to-mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Gurubaran, Iswariyaraja Sridevi; Koskela, Ali; Heloterae, Hanna; Kaarniranta, Kai. 2025. Acta ophthalmologica. [First published: 19 July 2025]: 1-13 B1 Kirjoitus tieteellisessä aikakauslehdessä

Autophagy in drusen biogenesis secondary to age-related macular degeneration

Hyttinen, Juha M T; Koskela, Ali; Blasiak, Janusz; Kaarniranta, Kai. 2024. Acta ophthalmologica. 102: 759-772 A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Liukkonen, Mikko; Heloterä, Hanna; Siintamo, Leea; Ghimire, Bishwa; Mattila, Pirkko; Kivinen, Niko; Kostanek, Joanna; Watala, Cezary; Hytti, Maria; Hyttinen, Juha; Koskela, Ali; Blasiak, Janusz; Kaarniranta, Kai. 2024. Investigative ophthalmology and visual science. 65: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai. 2023. Journal of biological chemistry. 299: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Vottonen, Linda; Koskela, Ali; Felszeghy, Szabolcs; Wylegala, Adam; Kryszan, Katarzyna; Gurubaran, Iswariyaraja Sridevi; Kaarniranta, Kai; Wylegala, Edward. 2023. Journal of clinical medicine. 12: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Koskela, Ali; Manai, Federico; Basagni, Filippo; Liukkonen, Mikko; Rosini, Michela; Govoni, Stefano; Monte, Massimo Dal; Smedowski, Adrian; Kaarniranta, Kai; Amadio, Marialaura. 2022. Antioxidants. 11: . 1385 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops

Pacwa, Anna; Machowicz, Joanna; Wojtyniak, Alicja; Pietrucha-Dutczak, Marita; Toropainen, Elisa; Koskela, Ali; Mrukwa-Kominek, Ewa; Lewin-Kowalik, Joanna; Smedowski, Adrian. 2022. Journal of inflammation research. 15: 793-806 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 1684 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-ß2 are elevated in a Finnish wet age-related macular degeneration cohort

Liukkonen, Mikko PK; Paterno, Jussi J; Kivinen, Niko; Siintamo, Leea; Koskela, Ali KJ; Kaarniranta, Kai. 2021. Acta ophthalmologica. [Epub ahead of print 26 Oct 2021]: 1-10 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali]. 2021. Autophagy. 17: 1-382 A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Tamminen, Toni; Koskela, Ali; Toropainen, Elisa; Gurubaran, Iswariyaraja Sridevi; Winiarczyk, Mateusz; Liukkonen, Mikko; Paterno, Jussi J; Lackman, Petri; Sadeghi, Amir; Viiri, Johanna; Hyttinen, Juha MT; Koskelainen, Ari; Kaarniranta, Kai. 2021. Oxidative medicine and cellular longevity. 2021: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai. 2020. Genes. 11: 1318 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2020. International journal of molecular sciences. 21: 2066 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K. 2019. International journal of molecular sciences. 20: 3773 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J. 2019. Oxidative medicine and cellular longevity. 2019: 9682318 A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K. 2019. Journal of cellular and molecular medicine. 23: 8464-8471 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Biochimie. 159: 49-54 A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Using online game-based platforms to improve student performance and engagement in histology teaching

Felszeghy, S; Pasonen-Seppänen, S; Koskela, A; Nieminen, P; Härkönen, K; Paldanius, KMA; Gabbouj, S; Ketola, K; Hiltunen, M; Lundin, M; Haapaniemi, T; Sointu, E; Bauman, EB; Gilbert, GE; Morton, D; Mahonen, A. 2019. Bmc medical education. 19: 273 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Oxidative medicine and cellular longevity. 2018: 4956080 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. International journal of molecular sciences. 18: 1089 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Duodecim. 133: 641-646 A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Felszeghy Szabolcs, Pasonen-Seppänen Sanna, Koskela Ali, Mahonen Anitta. 2017. MedEd publish. 6: 40 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. European journal of pharmacology. 788: 12-20 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutrients. 8: 284 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Oxidative medicine and cellular longevity. 2015, Article ID 340520: 24 p. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Molecular vision. 20: 760-769 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects

Törrönen R, McDougall GJ, Dobson G, Stewart D, Hellström J, Mattila P, Pihlava J-M, Koskela A, Karjalainen R. 2012. Journal of functional foods. 4: 746-756 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tarkenna hakuasi

Tutkimusryhmät

Julkaisut

Secretory autophagy and epithelial-to-mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Autophagy in drusen biogenesis secondary to age-related macular degeneration

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-ß2 are elevated in a Finnish wet age-related macular degeneration cohort

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Using online game-based platforms to improve student performance and engagement in histology teaching

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects