Hilkka Soininen

Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; Lehtisalo, Jenni; Mangialasche, Francesca; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Stephen, Ruth; Kivipelto, Miia; Solomon, Alina. 2024. Alzheimer's & dementia. [Epub ahead of print 22 April 2024]: 1-6 A1 Journal article (refereed), original research

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome

Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna. 2024. Journal of neuropathology and experimental neurology. 83: 967-978 A1 Journal article (refereed), original research

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

García-Marín, Luis M.; Campos, Adrian I.; Diaz-Torres, Santiago; Rabinowitz, Jill A.; Ceja, Zuriel; Mitchell, Brittany L.; Grasby, Katrina L.; Thorp, Jackson G.; Agartz, Ingrid; Alhusaini, Saud; Ames, David; Amouyel, Philippe; Andreassen, Ole A.; Arfanakis, Konstantinos; Arias-Vasquez, Alejandro; Armstrong, Nicola J.; Athanasiu, Lavinia; Bastin, Mark E.; Beiser, Alexa S.; Bennett, David A.; Bis, Joshua C.; Boks, Marco P. M.; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Buitelaar, Jan . 2024. Nature genetics. 56: 2333-2344 A1 Journal article (refereed), original research

Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)

Levak, Nicholas; Lehtisalo, Jenni; Thunborg, Charlotta; Westman, Eric; Andersen, Pia; Andrieu, Sandrine; Broersen, Laus M.; Coley, Nicola; Hartmann, Tobias; Irving, Gerd Faxén; Mangialasche, Francesca; Ngandu, Tiia; Pantel, Johannes; Rosenberg, Anna; Sindi, Shireen; Soininen, Hilkka; Solomon, Alina; Wang, Rui; Kivipelto, Miia. 2024. Alzheimer's research and therapy. 16: . 147 A1 Journal article (refereed), original research

Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer’s Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial

Hendrix, Suzanne B; Soininen, H; Solomon, A; Visser, PJ; van Hees, AMJ; Counotte, DS; Nicodemus-Johnson, J; Dickson, SP; Blennow, K; Kivipelto, M; Hartmann, T; LipiDiDiet clinical study group. 2023. The Journal of prevention of Alzheimer's disease. 10: 464-470 A1 Journal article (refereed), original research

FinnGen provides genetic insights from a well-phenotyped isolated population

Kurki, Mitja I.; Karjalainen, Juha; Palta, Priit; Sipilä, Timo P.; Kristiansson, Kati; Donner, Kati M.; Reeve, Mary P.; Laivuori, Hannele; Aavikko, Mervi; Kaunisto, Mari A.; Loukola, Anu; Lahtela, Elisa; Mattsson, Hannele; Laiho, Päivi; Della Briotta Parolo, Pietro; Lehisto, Arto A.; Kanai, Masahiro; Mars, Nina; Rämö, Joel; Kiiskinen, Tuomo; Heyne, Henrike O.; Veerapen, Kumar; Rüeger, Sina; Lemmelä, Susanna; Zhou, Wei; Ruotsalainen, Sanni; Pärn, Kalle; Hiekkalinna, Tero; Koskelainen, Sami; Paaja. 2023. Nature. 613: 508-518 A1 Journal article (refereed), original research

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration. 2023. JAMA network open. 6: A1 Journal article (refereed), original research

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research

Response to “Comment on ‘Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program’”

Wimo, Anders; Handels, Ron; Antikainen, Riitta; Eriksdotter, Maria; Jönsson, Linus; Knapp, Martin; Kulmala, Jenni; Laatikainen, Tiina; Lehtisalo, Jenni; Peltonen, Markku; Sköldunger, Anders; Soininen, Hilkka; Solomon, Alina; Timo Strandberg, T; Tuomilehto, Jaakko; Ngandu, Tiia; Kivipelto, Miia. 2023. Alzheimer's & dementia. 19: 4760-4763 B1 Non-refereed journal articles

The effect of physical activity on white matter integrity in aging and prodromal to mild Alzheimer's disease with vascular comorbidity

Konwar, Srijan; Manca, Riccardo; De Marco, Matteo; Soininen, Hilkka; Venneri, Annalena. 2023. Frontiers in aging neuroscience. 15: A1 Journal article (refereed), original research

The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

Rydstrom, Anders; Stephen, Ruth; Kareholt, Ingemar; Mattsson, Alexander Darin; Ngandu, Tiia; Lehtisalo, Jenni; Backman, Lars; Kemppainen, Nina; Rinne, Juha; Sindi, Shireen; Soininen, Hilkka; Vanninen, Ritva; Solomon, Alina; Mangialasche, Francesca. 2023. Gerontology. 69: 972-985 A1 Journal article (refereed), original research

Association Between Cognition, Health Related Quality of Life, and Costs in a Population at Risk for Cognitive Decline

Janssen, Niels; Handels, Ron L.; Wimo, Anders; Antikainen, Riitta; Laatikainen, Tiina; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Evers, Silvia M.A.A.; Verhey, Frans R.J.; Ngandu, Tiia. 2022. Journal of Alzheimer's disease. 89: 623-632 A1 Journal article (refereed), original research

Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial

Neuvonen, Elisa; Lehtisalo, Jenni; Ngandu, Tiia; Levälahti, Esko; Antikainen, Riitta; Hänninen, Tuomo; Laatikainen, Tiina; Lindström, Jaana; Paajanen, Teemu; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Solomon, Alina. 2022. Journal of clinical medicine. 11: A1 Journal article (refereed), original research

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Wimo, Anders; Handels, Ron; Antikainen, Riitta; Eriksdotter, Maria; Jönsson, Linus; Knapp, Martin; Kulmala, Jenni; Laatikainen, Tiina; Lehtisalo, Jenni; Peltonen, Markku; Sköldunger, Anders; Soininen, Hilkka; Solomon, Alina; Strandberg, Timo; Tuomilehto, Jaakko; Ngandu, Tiia; Kivipelto, Miia. 2022. Alzheimer's & dementia. [First published: 16 July 2022]: 1-10 A1 Journal article (refereed), original research

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

Lehtisalo, Jenni; Rusanen, Minna; Solomon, Alina; Antikainen, Riitta; Laatikainen, Tiina; Peltonen, Markku; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2022. European heart journal. 43: 2054–2061 A1 Journal article (refereed), original research

Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition

Wesenhagen, Kirsten E. J.; Gobom, Johan; Bos, Isabelle; Vos, Stephanie J. B.; Martinez-Lage, Pablo; Popp, Julius; Tsolaki, Magda; Vandenberghe, Rik; Freund-Levi, Yvonne; Verhey, Frans; Lovestone, Simon; Streffer, Johannes; Dobricic, Valerija; Bertram, Lars; Blennow, Kaj; Pikkarainen, Maria; Hallikainen, Merja; Kuusisto, Johanna; Laakso, Markku; Soininen, Hilkka; Scheltens, Philip; Zetterberg, Henrik; Teunissen, Charlotte E.; Visser, Pieter Jelle; Tijms, Betty M.; for the Alzheimer’s Disease Neur. 2022. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 14: A1 Journal article (refereed), original research

Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational Randomized Controlled Trial

Coley, Nicola; Andre, Laurine; Hoevenaar-Blom, Marieke P; Ngandu, Tiia; Beishuizen, Cathrien; Barbera, Mariagnese; van Wanrooij, Lennard; Kivipelto, Miia; Soininen, Hilkka; van Gool, Willem; Brayne, Carol; Moll van Charante, Eric; Richard, Edo; Andrieu, Sandrine; HATICE study group; PRODEMOS study group. 2022. Journal of medical internet research. 24: A1 Journal article (refereed), original research

Multimodal Preventive Trial for Alzheimer’s Disease: MIND-ADmini Pilot Trial Study Design and Progress

Sindi, S; Thunborg, C; Rosenberg, A; Andersen, P; Andrieu, S; Broersen, LM; Coley, N; Couderc, C; Duval, CZ; Faxen-Irving, G; Hagman, G; Hallikainen, M; Håkansson, K; Lehtisalo, J; Levak, N; Mangialasche, F; Pantel, J; Kekkonen, E; Rydström, A; Stigsdotter-Neely, A; Wimo, A; Ngandu, T; Soininen, H; Hartmann, T; Solomon, A; Kivipelto, M. 2022. The Journal of prevention of Alzheimer's disease. 9: 30-39 A1 Journal article (refereed), original research

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Em. 2022. Nature genetics. 54: 412-436 A1 Journal article (refereed), original research

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Jansen, Willemijn J.; Janssen, Olin; Tijms, Betty M.; Vos, Stephanie J. B.; Ossenkoppele, Rik; Visser, Pieter Jelle; Aarsland, Dag; Alcolea, Daniel; Altomare, Daniele; von Arnim, Christine; Baiardi, Simone; Baldeiras, Ines; Barthel, Henryk; Bateman, Randall J.; Van Berckel, Bart; Binette, Alexa Pichet; Blennow, Kaj; Boada, Merce; Boecker, Henning; Bottlaender, Michel; den Braber, Anouk; Brooks, David J.; Van Buchem, Mark A.; Camus, Vincent; Carill, Jose Manuel; Cerman, Jiri; Chen, Kewei; Chétela. 2022. JAMA neurology. 79: 228-243 A1 Journal article (refereed), original research

Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial

Neuvonen, Elisa; Lehtisalo, Jenni; Solomon, Alina; Antikainen, Riitta; Havulinna, Satu; Hänninen, Tuomo; Laatikainen, Tiina; Lindström, Jaana; Rautio, Nina; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia. 2022. Aging clinical and experimental research. 34: 1793-1805 A1 Journal article (refereed), original research

27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial

Sandebring-Matton, Anna; Goikolea, Julen; Björkhem, Ingemar; Paternain, Laura; Kemppainen, Nina; Laatikainen, Tiina; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Cedazo-Minguez, Angel; Solomon, Alina; Kivipelto, Miia. 2021. Alzheimer's research and therapy. 13: 56 A1 Journal article (refereed), original research

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2021. Journal of neurology. 268: 3283-3293 A1 Journal article (refereed), original research

A competing risk joint model for dealing with different types of missing data in an intervention trial in prodromal Alzheimer's disease

Swinkels, Sophie HN; Soininen, Hilkka; Kivipelto, Miia; Hartmann, Tobias; Rizopoulos, Dimitris. 2021. Alzheimer's research and therapy. 13: 63 A1 Journal article (refereed), original research

Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

Gudmundsson, Sanna; Karczewski, Konrad J.; Francioli, Laurent C.; Tiao, Grace; Cummings, Beryl B.; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L.; Laricchia, Kristen M.; Ganna, Andrea; Birnbaum, Daniel P.; Gauthier, Laura D.; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A.; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M.; Seaby, Eleanor G.; Kosmicki, Jack A. et al [incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2021. Nature. 597: E3-E4 B1 Non-refereed journal articles

Change in CAIDE Dementia Risk Score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis

Stephen, Ruth; Ngandu, Tiia; Liu, Yawu; Peltonen, Markku; Antikainen, Riitta; Kemppainen, Nina; Laatikainen, Tiina; Lötjönen, Jyrki; Rinne, Juha; Strandberg, Timo; Tuomilehto, Jaakko; Vanninen, Ritva; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2021. Journals of gerontology series a: biological sciences and medical sciences. 76: 1407-1414 A1 Journal article (refereed), original research

Characteristics of subjective cognitive decline associated with amyloid positivity

Janssen, Olin; Jansen, Willemijn J; Vos, Stephanie JB; Boada, Merce; Parnetti, Lucilla; Gabryelewicz, Tomasz; Fladby, Tormod; Molinuevo, José Luis; Villeneuve, Sylvia; Hort, Jakub; Epelbaum, Stéphane; Lleó, Alberto; Engelborghs, Sebastiaan; van der Flier, Wiesje M; Landau, Susan; Popp, Julius; Wallin, Anders; Scheltens, Philip; Olde Rikkert, Marcel; Snyder, Peter J; et al.; Alzheimer's Disease Neuroimaging Initiative; FACEHBI study group; PREVENT-AD research group. 2021. Alzheimer's & dementia. [Epub ahead of print 8 Dec 2021]: 1-14 A1 Journal article (refereed), original research

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; et al; [incl. Haapasalo, A; Soininen, H; Lehtisalo, J; Kivipelto, M; Kuulasmaa, T; Hiltunen, M]. 2021. Nature communications. 12: 3417 A1 Journal article (refereed), original research

Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

Solomon, Alina; Handels, Ron; Wimo, Anders; Antikainen, Riitta; Laatikainen, Tiina; Levälahti, Esko; Peltonen, Markku; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia. 2021. Journal of Alzheimer's disease. 82: 1461-1466 A1 Journal article (refereed), original research

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Nabais, Marta F; Laws, Simon M; Lin, Tian; Vallerga, Costanza L; Armstrong, Nicola J; Blair, Ian P; Kwok, John B; Mather, Karen A; Mellick, George D; Sachdev, Perminder S; Wallace, Leanne; Henders, Anjali K; Zwamborn, Ramona AJ; Hop, Paul J; Lunnon, Katie; Pishva, Ehsan; Roubroeks, Janou AY; Soininen, Hilkka; Tsolaki, Magda; Mecocci, Patrizia; the Australian Imaging Biomarkers and Lifestyle study; et al. 2021. Genome biology. 22: 90 A1 Journal article (refereed), original research

Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease

Whiley, Luke; Chappell, Katie E; D'Hondt, Ellie; Lewis, Matthew R; Jiménez, Beatriz; Snowden, Stuart G; Soininen, Hilkka; Kloszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Swann, Jonathan R; Hye, Abdul; Lovestone, Simon; Legido-Quigley, Cristina; Holmes, Elaine. 2021. Alzheimer's research and therapy. 13: 20 A1 Journal article (refereed), original research

Muistisairaudet

Lehtisalo, Jenni; Kivipelto, Miia; Ngandu, Tiia; Eskelinen, Marjo; Soininen, Hilkka. Teoksessa: Mutanen, Marja; Niinikoski, Harri; Schwab, Ursula; Uusitupa, Matti(toim.) , 2021. Ravitsemustiede (8. uud. painos). s. 461-466. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study

Dake, Manmohi D; De Marco, Matteo; Blackburn, Daniel J; Wilkinson, Iain D; Remes, Anne; Liu, Yawu; Pikkarainen, Maria; Hallikainen, Merja; Soininen, Hilkka; Venneri, Annalena. 2021. Journal of Alzheimer's disease reports. 5: 65-77 A1 Journal article (refereed), original research

Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.

Deckers, Kay; Köhler, Sebastian; Ngandu, Tiia; Antikainen, Riitta; Laatikainen, Tiina; Soininen, Hilkka; Strandberg, Timo; Verhey, Frans; Kivipelto, Miia; Solomon, Alina. 2021. Alzheimer's & dementia. 17: 1205-1212 A1 Journal article (refereed), original research

Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial

Rosenberg, Anna; Solomon, Alina; Soininen, Hilkka; Visser, Pieter Jelle; Blennow, Kaj; Hartmann, Tobias; Kivipelto, Miia; on behalf of the LipiDiDiet clinical study group [incl. Hallikainen, Ilona; Hallikainen, Merja; Helisalmi, Seppo; Lappalainen, Tarja; Liu, Yawu; Paajanen, Teemu]. 2021. Alzheimer's research and therapy. 13: 64 A1 Journal article (refereed), original research

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko. 2021. Neurobiology of disease. 2022; 163: 105603 A1 Journal article (refereed), original research

Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial

Sindi, Shireen; Solomon, Alina; Kåreholt, Ingemar; Hovatta, Iiris; Antikainen, Riitta; Hänninen, Tuomo; Levälahti, Esko; Laatikainen, Tiina; Lehtisalo, Jenni; Lindström, Jaana; Paajanen, Teemu; Peltonen, Markku; Singh Khalsa, Dharma; Wolozin, Benjamin; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Ngandu, Tiia; Kivipelto, Miia; for the FINGER Study Group. 2021. Journals of gerontology series a: biological sciences and medical sciences. 76: 491-498 A1 Journal article (refereed), original research

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

Simrén, Joel; Leuzy, Antoine; Karikari, Thomas K; Hye, Abdul; Benedet, Andréa Lessa; Lantero-Rodriguez, Juan; Mattsson-Carlgren, Niklas; Schöll, Michael; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; Soininen, Hilkka; Lovestone, Simon; Aarsland, Dag; Hansson, Oskar; Rosa-Neto, Pedro; Westman, Eric; Blennow, Kaj; Zetterberg, Henrik; et al; AddNeuroMed consortium. 2021. Alzheimer's & dementia. 17: 1145-1156 A1 Journal article (refereed), original research

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Ngandu, Tiia; Lehtisalo, Jenni; Korkki, Saana; Solomon, Alina; Coley, Nicola; Antikainen, Riitta; Bäckman, Lars; Hänninen, Tuomo; Lindström, Jaana; Laatikainen, Tiina; Paajanen, Teemu; Havulinna, Satu; Peltonen, Markku; Neely, Anna Stigsdotter; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia. 2021. Alzheimer's & dementia. First published: 20 October 2021: 1 - 10 A1 Journal article (refereed), original research

Voiko kliininen ravintovalmiste jarruttaa muistisairauden etenemistä?

Soininen, Hilkka. 2021. Lääkärilehti. 76: 915 D1 Article in a trade journal

36-month LipiDiDiet multinutrient clinical trial in prodromal Alzheimer's disease

Soininen, Hilkka; Solomon, Alina; Visser, Pieter Jelle; Hendrix, Suzanne B; Blennow, Kaj; Kivipelto, Miia; Hartmann, Tobias; Hallikainen, Ilona; Hallikainen, Merja; Helisalmi, Seppo; Lappalainen, Tarja; Liu, Yawu; Paajanen, Teemu; Wahlund, Lars-Olof; Freund-Levi, Yvonne; Hagman, Göran; Hartmann, Tobias; Fassbender, Klaus; Riemenschneider, Matthias; Grimm, Marcus OW et al.. 2020. Alzheimer's & dementia. 2021; 17: 29-40 A1 Journal article (refereed), original research

A structural variation reference for medical and population genetics

Collins, Ryan L; Brand, Harrison; Karczewski, Konrad J; Zhao, Xuefang; Alföldi, Jessica; Francioli, Laurent C; Khera, Armit V; Lowther, Chelsea; Gauthier, Laura D; Wang, Harold; Watts, Nicholas A; Solomonson, Matthew; O'Donnell-Luria, Anne; Baumann, Alexander; Munshi, Ruchi; Walker, Mark; Whelan, Christopher W; Huang, Yongqing; Brookings, Ted; Sharpe, Ted; et al.; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen. 2020. Nature. 581: 444-451 A1 Journal article (refereed), original research

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Roubroeks, Janoy AY; Smith, Adam R; Smith, Rebecca G; Pishva, Ehsan; Ibrahim, Zina; Sattlecker, Martina; Hannon, Eilis J; Kloszewska, Iwona; Mecocci, Patrizia; Soininen, Hilkka; Tsolaki, Magda; Vellas, Bruno; Wahlund, Lars-Olof; Aarsland, Dag; Proitsi, Petroula; Hodges, Angela; Lovestone, Simon; Newhouse, Stephen J; Dobson, Richard JB; Mill, Jonathan; et al.. 2020. Neurobiology of aging. 95: 26-45 A1 Journal article (refereed), original research

Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus With Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia

Pekkala, Timo; Hall, Anette; Mangialasche, Francesca; Kemppainen, Niina; Mecocci, Patrizia; Ngandu, Tiia; Rinne, Juha O; Soininen, Hilkka; Tuomilehto, Jaakko; Kivipelto. Miia; Solomon. Alina 1 2. 2020. Journal of Alzheimer's disease. 76: 1243-1248 A1 Journal article (refereed), original research

Attitudes of at-risk older adults about prevention of cardiovascular disease and dementia using eHealth: a qualitative study in a European context.

Akenine, Ulrika; Barbera, Mariagnese; Beishuizen, Cathrien Rl; Fallah Pour, Mandana; Guillemont, Juliette; Rosenberg, Anna; Coley, Nicola; Mangialasche, Francesca; Salo, Lotta; Savy, Stephanie; Pols, A Jeannette; Andrieu, Sandrine; Richard, Edo; Soininen, Hilkka; Moll van Charante, Eric; Kivipelto, Miia; The HATICE study group. 2020. BMJ open. 10: e037050 A1 Journal article (refereed), original research

Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland

Liang, Yajun; Ngandu, Tiia; Laatikainen, Tiina; Soininen, Hilkka; Tuomilehto, Jaakko; Kivipelto, Miia; Qiu, Chengxuan. 2020. PLoS medicine. 17: e1003474 A1 Journal article (refereed), original research

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

Whiffin, Nicola; Karczewski, Konrad J; Zhang, Xiaolei; Chothani, Sonia; Smith, Miriam J; Evans, D Gareth; Roberts, Angharad M; Quaife, Nicholas M; Schafer, Sebastian; Rackham, Owen; Alföldi, Jessica; O'Donnell-Luria, Anne H; Francioli, Laurent C; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature communications. 11: 2523 A1 Journal article (refereed), original research

Dementia risk scores as surrogate outcomes for lifestyle-based multidomain prevention trials - rationale, preliminary evidence and challenges

Coley, N; Hoevenaar-Blom, MP; van Dalen, JW; Moll van Charante, EP; Kivipelto, M; Soininen, H; Andrieu, S; Richard, E. 2020. Alzheimer's & dementia. 16: 1674-1685 A1 Journal article (refereed), original research

Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline

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Rosenberg, Anna; Coley, Nicola; Soulier, Alexandra; Kulmala, Jenni; Soininen, Hilkka; Andrieu, Sandrine; Kivipelto, Miia; Barbera, Mariagnese; for the MIND-AD and HATICE groups. 2020. Bmc geriatrics. 20: 99 A1 Journal article (refereed), original research

Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

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Neuvonen, Elisa; Hall, Anette; Tolppanen, Anna-Maija; Ngandu, Tiia; Rusanen, Minna; Laatikainen, Tiina; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2020. International journal of geriatric psychiatry. 35: 989-999 A1 Journal article (refereed), original research

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Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol

Barbera, Mariagnese; Kulmala, Jenni; Lisko, Inna; Pietilä, Eija; Rosenberg, Anna; Hallikainen, Ilona; Hallikainen, Merja; Laatikainen, Tiina; Lehtisalo, Jenni; Neuvonen, Elisa; Rusanen, Minna; Soininen, Hilkka; Tuomilehto, Jaakko; Ngandu, Tiia; Solomon, Alina; Kivipelto, Miia. 2020. Bmc geriatrics. 20: 238 A1 Journal article (refereed), original research

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van Waalwijk van Doorn, Linda J C; Ghafoorian, Mohsen; van Leijsen, Esther M C; Claassen, Jurgen A H R; Arighi, Andrea; Bozzali, Marco; Cannas, Jorge; Cavedo, Enrica; Eusebi, Paolo; Farotti, Lucia; Fenoglio, Chiara; Fortea, Juan; Frisoni, Giovanni B; Galimberti, Daniela; Greco, Viviana; Herukka, Sanna-Kaisa; Liu, Yawu; Lleó, Alberto; de Mendonça, Alexandre; Nobili, Flavio M; et al. [incl. Pikkarainen, Maria; Soininen, Hilkka]. 2020. Journal of Alzheimer's disease. 2021; 79: 163-175 A1 Journal article (refereed), original research

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cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders

Rhodius-Meester, HFM; Paajanen, T; Koikkalainen, J; Mahdiani, S; Bruun, M; Baroni, M; Lemstra, AW; Scheltens, P; Herukka, SK; Pikkarainen, M; Hall, A; Hänninen, T; Ngandu, T; Kivipelto, M; van Gils, M; Hasselbalch, SG; Mecocci, P; Remes, A; Soininen, H; van der Flier, WM; Lötjönen, J. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 12: e12083 A1 Journal article (refereed), original research

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Coley, N; Ngandu, T; Lehtisalo, J; Soininen, H; Vellas, B; Richard, E; Kivipelto, M; Andrieu, S; HATICE, FINGER, MAPT/DSA groups. 2019. Alzheimer's & dementia. 15: 729-741 A1 Journal article (refereed), original research

Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in alzheimer's disease

Jones, Sarah Amy; De Marco, Matteo; Manca, Riccardo; Bell, Simon M; Blackburn, Daniel J; Wilkinson, Iain D; Soininen, Hilkka; Venneri, Annalena. 2019. Cortex. 119: 100-110 A1 Journal article (refereed), original research

Alzheimer's Disease Composite Score: A Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer's Disease

Hendrix, Suzanne B; Soininen, H; van Hees, AMJ; Ellison, N; Visser, PJ; Solomon, A; Attali, A; Blennow, K; Kivipelto, M; Hartmann, T. 2019. The Journal of prevention of Alzheimer's disease. 6: 232-236 A1 Journal article (refereed), original research

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Lehtisalo, J; Levälahti, E; Lindström, J; Hänninen, T; Paajanen, T; Peltonen, M; Antikainen, R; Laatikainen, T; Strandberg, T; Soininen, H; Tuomilehto, J; Kivipelto, M; Ngandu, T. 2019. Alzheimer's & dementia. 15: 410-417 A1 Journal article (refereed), original research

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease

Boccardi, V; Westman, E; Pelini, L; Lindberg, O; Muehlboeck, JS; Simmons, A; Tarducci, R; Floridi, P; Chiarini, P; Soininen, H; Kloszewska, I; Tsolaki, M; Vellas, B; Spenger, C; Wahlund, LO; Lovestone, S; Mecocci, P. 2019. Frontiers in aging neuroscience. 10: 439 A1 Journal article (refereed), original research

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Kivipelto, Miia; Kulmala, Jenni; Lehtisalo, Jenni; Solomon, Alina; Lindström, Jaana; Rauramaa, Rainer; Peltonen, Markku; Laatikainen, Tiina; Havulinna, Satu; Soininen, Hilkka; Tuomilehto, Jaakko; Hänninen, Tuomo; Paajanen, Teemu; Antikainen, Riitta; Strandberg, Timo; Ngandu, Tiia. 2019. Lääkärilehti. 74: 183-186 D1 Article in a trade journal

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Beishuizen, CR; Akenine, U; Barbera, M; Rosenberg, A; Fallah Pour, M; Richard, E; Soininen, H; Mangialasche, F; Kivipelto, M; Pols, AJ; Moll van Charante, E. 2019. BMJ open. 9: e023480 A1 Journal article (refereed), original research

Long-term dementia risk prediction by the LIBRA score: a 30-year follow-up of the CAIDE study

Deckers, K; Barbera, M; Köhler, S; Ngandu, T; van Boxtel, M; Rusanen, M; Laatikainen, T; Verhey, F; Soininen, H; Kivipelto, M; Solomon, A. 2019. International journal of geriatric psychiatry. 2020; 35: 195-203 A1 Journal article (refereed), original research

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients

Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease. 72: 127-137 A1 Journal article (refereed), original research

Midlife improvements in financial situation are associated with a reduced dementia risk later in life: The CAIDE 30-Year Study

Sindi, S; Darin-Mattsson, A; Kåreholt, I; Kulmala, J; Ngandu, T; Laatikainen, T; Soininen, H; Kivipelto, M. 2019. International psychogeriatrics. [Published online 25 November 2019]: 1-8 A1 Journal article (refereed), original research

Muistiterveys

Soininen, Hilkka. Teoksessa: Pietilä, Anna-Maija; Terkamo-Moisio, Anja(toim.) , 2019. Näkökulmia terveyteen ja sen edistämiseen. s. 167-176. Itä-Suomen yliopisto B2 Book section

Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison

Coley, N; Rosenberg, A; van Middelaar, T; Soulier, A; Barbera, M; Guillemont, J; Steensma, J; Igier, V; Eskelinen, M; Soininen, H; Moll van Charante, E; Richard, E; Kivipelto, M; Andrieu, S. 2019. Journal of the american medical directors association. 20: 843-849.e5 A1 Journal article (refereed), original research

Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus

Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease. 71: 1233-1243 A1 Journal article (refereed), original research

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study

Hall, A; Pekkala, T; Polvikoski, T; van Gils, M; Kivipelto, M; Lötjönen, J; Mattila, J; Kero, M; Myllykangas, L; Mäkelä, M; Oinas, M; Paetau, A; Soininen, H; Tanskanen, M; Solomon, A. 2019. Alzheimer's research and therapy. 11: 11 A1 Journal article (refereed), original research

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus

Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Dementia and geriatric cognitive disorders. 47: 91-103 A1 Journal article (refereed), original research

Self and Informant Memory Reports in FINGER: Associations with Two-Year Cognitive Change

Vaskivuo, L; Hokkanen, L; Hänninen, T; Antikainen, R; Bäckman, L; Laatikainen, T; Paajanen, T; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Soininen, H; Kivipelto, M; Ngandu, T. 2019. Journal of Alzheimer's disease. 71: 785-795 A1 Journal article (refereed), original research

Serum insulin and cognitive performance in older adults: a longitudinal study

Hooshmand, B; Rusanen, M; Ngandu, T; Leiviskä, J; Sindi, S; von Arnim, CAF; Falkai, P; Soininen, H; Tuomilehto, J; Kivipelto, M. 2019. American journal of medicine. 132: 367-373 A1 Journal article (refereed), original research

The Association Between Distinct Frontal Brain Volumes and Behavioral Symptoms in Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia

Cajanus, A; Solje, E; Koikkalainen, J; Lötjönen, J; Suhonen, NM; Hallikainen, I; Vanninen, R; Hartikainen, P; de Marco, M; Venneri, A; Soininen, H; Remes, AM; Hall, A. 2019. Frontiers in neurology. 10: 1059 A1 Journal article (refereed), original research

The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People

Kulmala, J; Ngandu, T; Havulinna, S; Levälahti, E; Lehtisalo, J; Solomon, A; Antikainen, R; Laatikainen, T; Pippola, P; Peltonen, M; Rauramaa, R; Soininen, H; Strandberg, T; Tuomilehto, J; Kivipelto, M. 2019. Journal of the american geriatrics society. 67: 1138-1144 A1 Journal article (refereed), original research

Understanding the effect of cognitive/brain reserve and depression on regional atrophy in early Alzheimer's disease

Capogna, E; Manca, R; De Marco, M; Hall, A; Soininen, H; Venneri, A. 2019. Postgraduate medicine. 131: 533-538 A1 Journal article (refereed), original research

Using joint models to disentangle intervention effect types and baseline confounding: an application within an intervention study in prodromal Alzheimer's disease with Fortasyn Connect

van Oudenhoven, FM; Swinkels, SHN; Hartmann, T; Soininen, H; van Hees, AMJ; Rizopoulos, D. 2019. Bmc medical research methodology. 19: 163 A1 Journal article (refereed), original research

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus

Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. Journal of Alzheimer's disease. 67: 1343-1351 A1 Journal article (refereed), original research

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

Marttinen, M; Paananen, J; Neme, A; Mitra, V; Takalo, M; Natunen, T; Paldanius, KMA; Mäkinen, P; Bremang, M; Kurki, MI; Rauramaa, T; Leinonen, V; Soininen, H; Haapasalo, A; Pike, I; Hiltunen, M. 2018. Neurobiology of disease. 2019; 124: 454-468 A1 Journal article (refereed), original research

Alzheimerin taudin haaste - patofysiologiasta hoidon tutkimukseen

Soininen, Hilkka. 2018. Duodecim. 134: 2509-2510 D1 Article in a trade journal

Associations between Prospective and Retrospective Subjective Memory Complaints and Neuropsychological Performance in Older Adults: The Finger Study

Vaskivuo, Laura; Hokkanen, Laura; Hänninen, Tuomo; Antikainen, Riita; Bäckman, Lars; Laatikainen, Tiina; Paajanen, Teemu; Stigsdotter-Neely, Anna; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2018. Journal of the international neuropsychological society. 24: 1099-1109 A1 Journal article (refereed), original research

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

Cajanus, A; Hall, A; Koikkalainen, J; Solje, E; Tolonen, A; Urhemaa, T; Liu, Y; Haanpää, RM; Hartikainen, P; Helisalmi, S; Korhonen, V; Rueckert, D; Hasselbalch, S; Waldemar, G; Mecocci, P; Vanninen, R; van Gils, M; Soininen, H; Lötjönen, J; Remes, AM. 2018. Dementia and geriatric cognitive disorders extra. 8: 51-59 A1 Journal article (refereed), original research

Brain ß-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline

Martikainen, IK; Kemppainen, N; Johansson, J; Teuho, J; Helin, S; Liu, Y; Helisalmi, S; Soininen, H; Parkkola, R; Ngandu, T; Kivipelto, M; Rinne, JO. 2018. American journal of neuroradiology. 2019; 40: 80-85 A1 Journal article (refereed), original research

Cardiorespiratory fitness and risk of dementia: a prospective population-based cohort study

Kurl, S; Laukkanen, J A; Lönnroos, E; Remes, A M; Soininen, H. 2018. Age and ageing. 47: 611-614 A1 Journal article (refereed), original research

Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH

Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Neurology : Genetics. 4: e291 A1 Journal article (refereed), original research

Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier

Tolonen, Antti; Rhodius-Meester, Hanneke FM; Bruun, Marie; Koikkalainen, Juha; Barkhof, Frederik; Lemstra, Afina W; Koene, Teddy; Scheltens, Philip; Teunissen, Charlotte E; Tong, Tong; Guerrero, Ricardo; Schuh, Andreas; Ledig, Christian; Baroni, Marta; Rueckert, Daniel; Soininen, Hilkka; Remes, Anne M; Waldemar, Gunhild; Hasselbalch, Steen G; Mecocci, Patrizia; et al.. 2018. Frontiers in aging neuroscience. 10: 111 A1 Journal article (refereed), original research

Decreased plasma C-reactive protein levels in APOE E 4 allele carriers

Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Annals of clinical and translational neurology. 5: 1229-1240 A1 Journal article (refereed), original research

Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial

Solomon, A; Turunen, H; Ngandu, T; Peltonen, M; Levälahti, E; Helisalmi, S; Antikainen, R; Bäckman, L; Hänninen, T; Jula, A; Laatikainen, T; Lehtisalo, J; Lindström, J; Paajanen, T; Pajala, S; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Soininen, H; Kivipelto, M. 2018. JAMA neurology. 75: 462-470 A1 Journal article (refereed), original research

Epilepsy in neuropathologically verified Alzheimer's disease

Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Seizure: european journal of epilepsy. 58: 9-12 A1 Journal article (refereed), original research

Evaluating combinations of diagnostic tests to discriminate different dementia types

Bruun, Marie; Rhodius-Meester, Hanneke FM; Koikkalainen, Juha; Baroni, Marta; Gjerum, Le; Lemstra, Afina W; Barkhof, Frederik; Remes, Anne M; Urhemaa, Timo; Tolonen, Antti; Rueckert, Daniel; van Gils, Mark; Frederiksen, Kristian S; Waldemar, Gunhild; Scheltens, Philip; Mecocci, Patrizia; Soininen, Hilkka; Lötjönen, Jyrki; Hasselbalch, Steen G; van der Flier, Wiesje M. 2018. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 10: 509-518 A1 Journal article (refereed), original research

Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life

Sindi, Shireen; Kåreholt, Ingemar; Eskelinen, Marjo; Hooshmand, Babak; Lehtisalo, Jenni; Soininen, Hilkka; Ngandu, Tiia; Kivipelto, Miia. 2018. Nutrients. 10: 1649 A1 Journal article (refereed), original research

Heterogeneous patterns of brain atrophy in Alzheimer's disease

Poulakis, Konstantinos; Pereira, Joana B; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; Soininen, Hilkka; Lovestone, Simon; Simmons, Andrew; Wahlund, Lars-Olof; Westman, Eric. 2018. Neurobiology of aging. 65: 98-108 A1 Journal article (refereed), original research

Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus

Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. World neurosurgery. 112: e624-e631 A1 Journal article (refereed), original research

Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples

Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Journal of Alzheimer's disease. 62: 269-278 A1 Journal article (refereed), original research

Melatonin receptor type 1A gene linked to Alzheimer's disease in old age

Sulkava, S; Muggalla, P; Sulkava, R; Ollila, HM; Peuralinna, T; Myllykangas, L; Kaivola, K; Stone, DJ; Traynor, BJ; Renton, AE; Rivera, AM; Helisalmi, S; Soininen, H; Polvikoski , T; Hiltunen, M; Tienari, PJ; Huttunen, HJ; Paunio, T. 2018. Sleep. 41: 1-10 A1 Journal article (refereed), original research

Muistiystävällisiä tutkimustekoja

Soininen, Hilkka. 2018. MUISTI. 31: 5 E1 Popularised article, newspaper article

Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial

Rosenberg, A; Ngandu, T; Rusanen, M; Antikainen, R; Bäckman, L; Havulinna, S; Hänninen, T; Laatikainen, T; Lehtisalo, J; Levälahti, E; Lindström, J; Paajanen, T; Peltonen, M; Soininen, H; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Solomon, A; Kivipelto, M. 2018. Alzheimer's & dementia. 14: 263-270 A1 Journal article (refereed), original research

Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus

Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Neurosurgery. 2019; 84: 883-889 A1 Journal article (refereed), original research

Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers

de Matos, MR; Ferreira, C; Herukka, SK; Soininen, H; Janeiro, A; Santana, I; Baldeiras, I; Almeida, MR; Lleó, A; Dols-Icardo, O; Alcolea, D; Benussi, L; Binetti, G; Paterlini, A; Ghidoni, R; Nacmias, B; Meulenbroek, O; van Waalwijk van Doorn, LJC; Kuiperij, HB; Hausner, L; et al. 2018. Journal of Alzheimer's disease. 66: 639-652 A1 Journal article (refereed), original research

Sleep disturbances and dementia risk: A multicenter study

Sindi, S; Kåreholt, I; Johansson, L; Skoog, J; Sjöberg, L; Wang, HX; Johansson, B; Fratiglioni, L; Soininen, H; Solomon, A; Skoog, I; Kivipelto, M. 2018. Alzheimer's & dementia. 14: 1235-1242 A1 Journal article (refereed), original research

Sleep disturbances and later cognitive status: a multi-centre study

Sindi, S; Johansson, L; Skoog, J; Mattsson, AD; Sjöberg, L; Wang, HX; Fratiglioni, L; Kulmala, J; Soininen, H; Solomon, A; Johansson, B; Skoog, I; Kivipelto, M; Kåreholt, I. 2018. Sleep medicine. 52: 26-33 A1 Journal article (refereed), original research

Stability of graph theoretical measures in structural brain networks in Alzheimer's disease

Martensson, Gustav; Pereira, Joana B; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; Soininen, Hilkka; Lovestone, Simon; Simmons, Andrew; Volpe, Giovanni; Westman, Eric. 2018. Scientific reports. 8: 11592 A1 Journal article (refereed), original research

Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject

Haapalinna, F; Kokki, M; Jääskeläinen, O; Hallikainen, M; Helisalmi, S; Koivisto, A; Kokki, H; Paajanen, T; Penttinen, J; Pikkarainen, M; Rautiainen, M; Soininen, H; Solje, E; Remes, AM; Herukka, SK. 2018. Journal of Alzheimer's disease. 62: 165-174 A1 Journal article (refereed), original research

Suomeen perustetaan kansallinen neurokeskus: Perustutkimuksen innovaatiot kliiniseen testaukseen ja käyttöön [Pääkirjoitus]

von und zu Fraunberg, Mikael; Jaronen, Merja; Soininen, Hilkka. 2018. Duodecim. 134: 1661-1662 D1 Article in a trade journal

Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

Ore¨ic, M; Anderson, G; Mattila, I; Manoucheri, M; Soininen, H; Hyötyläinen, T; Basignani, C. 2018. Frontiers in neuroscience. 11: 747 A1 Journal article (refereed), original research

The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity - the FINGER Randomized Controlled Trial

Marengoni, A; Rizzuto, D; Fratiglioni, L; Antikainen, R; Laatikainen, T; Lehtisalo, J; Peltonen, M; Soininen, H; Strandberg, T; Tuomilehto, J; Kivipelto, M; Ngandu, T. 2018. Journal of the american medical directors association. 19: 355-360.e1 A1 Journal article (refereed), original research

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

Bis, JC; Jian, X; Kunkle, BW; Chen, Y; Hamilton-Nelson, KL; Bush, WS; Salerno, WJ; Lancour, D; Ma, Y; Renton, AE; Marcora, E; Farrell, JJ; Zhao, Y; Qu, L; Ahmad, S; Amin, N; Amouyel, P; Beecham, GW; Below, JE; Campion, D; et al [ Incl Helisalmi, Seppo; HIltunen, Mikko; Remes, Anne; Soininen, Hilkka]. 2018. Molecular psychiatry. [Published: 14 August 2018]: 1-17 A1 Journal article (refereed), original research

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

Soininen Hilkka, Solomon Alina, Jelle Visser Pieter, Hendrix Suzanne B, Blennow Kaj, Kivipelto Miia, Hartmann Tobias, LipiDiDiet clinical study group. 2017. The Lancet Neurology. 16: 965-975 A1 Journal article (refereed), original research

A Multi-Cohort Study of ApoE e4 and Amyloid-ß Effects on the Hippocampus in Alzheimer's Disease

Khan W, Giampietro V, Banaschewski T, Barker GJ, Bokde ALW, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaître H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka MN, Ströhle A et al.. 2017. Journal of Alzheimer's disease. 56: 1159-1174 A1 Journal article (refereed), original research

Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus

Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Journal of Alzheimer's disease. 60: 1077-1085 A1 Journal article (refereed), original research

Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study

Reijs BLR, Vos SJB, Soininen H, Lötjonen J, Koikkalainen J, Pikkarainen M, Hall A, Vanninen R, Liu Y, Herukka SK, Freund-Levi Y, Frisoni GB, Frölich L, Nobili F, Rikkert MO, Spiru L, Tsolaki M, Wallin ÅK, Scheltens P1, Verhey F, Visser PJ. 2017. Journal of Alzheimer's disease. 60: 1387-1395 A1 Journal article (refereed), original research

Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

Kim Min, Nevado-Holgado Alejo, Whiley Luke, Snowden Stuart G, Soininen Hilkka, Kloszewska Iwona , Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Thambisetty Madhav, Dobson Richard JB, Powell John F, Lupton Michelle K, Simmons Andyi, Velayudhan Latha, Lovestone Simon, Proitsi Petroula, Legido-Quigley Cristina. 2017. Journal of Alzheimer's disease. 60: 809-817 A1 Journal article (refereed), original research

Association of Cerebral Amyloid-ß Aggregation With Cognitive Functioning in Persons Without Dementia

Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J et al.. 2017. JAMA psychiatry. 75: 84-95 A1 Journal article (refereed), original research

Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, Lupton MK, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Powell JF, Dobson RJ, Legido-Quigley C. 2017. Alzheimer's & dementia. 13: 140-151 A1 Journal article (refereed), original research

Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition

Stephen R, Liu Y, Ngandu T, Rinne JO, Kemppainen N, Parkkola R, Laatikainen T, Paajanen T, Hänninen T, Strandberg T, Antikainen R, Tuomilehto J, Keinänen Kiukaanniemi S, Vanninen R, Helisalmi S, Levälahti E, Kivipelto M, Soininen H, Solomon A. 2017. Journal of Alzheimer's disease. 59: 695-705 A1 Journal article (refereed), original research

Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial

Sindi Shireen, Ngandu Tiia, Hovatta Iiris, Kåreholt Ingemar, Antikainen Riitta, Hänninen Tuomo, Levälahti Esko, Laatikainen Tiina, Lindström Jaana, Paajanen Teemu, Peltonen Markku, Khalsa Dharma Singh, Wolozin Benjamin, Strandberg Timo, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia, Solomon Alina. 2017. Journal of Alzheimer's disease. 59: 1459-1470 A1 Journal article (refereed), original research

Brain amyloid load and its associations with cognition and vascular risk factors in FINGER study

Kemppainen Nina, Johansson Jarkko, Teuho Jarmo, Parkkola Riitta, Joutsa Juho, Ngandu Tiika, Solomon Alina, Stephen Ruth, Liu Yawu, Hänninen Tuomo, Paajanen Teemu, Laatikainen Tiina, Soininen Hilkka, Jula Antti, Rokka Johanna, Rissanen Eero, Vahlberg Tero, Peltoniemi Julia, Kivipelto Miia, Rinne Juha O. 2017. Neurology. 2018; 90: e206-e213 A1 Journal article (refereed), original research

Cardiorespiratory fitness and brain volumes in men and women in the FINGER study

Pentikäinen Heikki, Ngandu Tiia, Liu Yawu, Savonen Kai, Komulainen Pirjo, Hallikainen Merja, Kivipelto Miia, Rauramaa Rainer, Soininen Hilkka. 2017. Age and ageing. 46: 310-313 A1 Journal article (refereed), original research

Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants

Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD et al.. 2017. PLoS ONE. 12: e0185777 A1 Journal article (refereed), original research

Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

Bos Isabelle, Verhey Frans R, Ramakers Inez HGB, Jacobs Heidi IL, Soininen Hilkka, Freund-Levi Yvonne, Hampel Harald, Tsolaki Magda, Wallin Åsa K, van Buchem Mark A, Oleksik Ania, Verbeek Marcel M, Rikkert Marcel Olde, van der Flier Wiesje M, Scheltens Philip, Aalten Pauline, Visser Pieter Jelle, Vos Stephanie JB. 2017. Alzheimer's research and therapy. 9: 101 A1 Journal article (refereed), original research

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation. : 215 A1 Journal article (refereed), original research

Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers

Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Annals of neurology. 82: 128-132 A1 Journal article (refereed), original research

Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting

Tong T, Ledig C, Guerrero R, Schuh A, Koikkalainen J, Tolonen A, Rhodius H, Barkhof F, Tijms B, Lemstra AW, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, Baroni M, Lötjönen J, Flier WV, Rueckert D. 2017. Neuroimage : clinical. 15: 613-624 A1 Journal article (refereed), original research

Genetic risk factors in Finnish patients with Parkinson's disease

Ylönen Susanna, Siitonen Ari, Nalls Michael A, Ylikotila Pauli, Autere Jaana, Eerola-Rautio Johanna, Gibbs Raphael, Hiltunen Mikko, Tienari Pentti J, Soininen Hilkka, Singleton Andrew B, Majamaa Kari. 2017. Parkinsonism and related disorders. 45: 39-43 A1 Journal article (refereed), original research

Health-related quality of life in a multidomain intervention trial to prevent cognitive decline (FINGER)

Strandberg TE, Levälahti E, Ngandu T, Solomon A, Kivipelto M, Lehtisalo J, Laatikainen T, Soininen H, Antikainen R, Jula A, Tuomilehto J, Peltonen M, Lindström J, Rauramaa R, Pajala S, Hänninen T, Solomon A, Paajanen T, Mangialasche F, FINGER Study Group. 2017. European geriatric medicine. 8: 164-167 A1 Journal article (refereed), original research

Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes

van Waalwijk van Doorn LC, Gispert JD, Kuiperij HB, Claassen, JAHR, Arighi A, Baldeiras I, Blennow K, Bozzali M, Castelo-Branco M, Cavedo E, Emek-Savas D, Eren E, Eusebi P, Farotti L, Fenoglio C, Ormaechea JF, Freund-Levi Y, Frisoni G, Galimberti D, Genc S et al. 2017. Journal of Alzheimer's disease. 56: 543-555 A1 Journal article (refereed), original research

Improving data sharing in research with context-free encoded missing data

Hoevenaar-Blom MP, Guillemont J, Ngandu T, Beishuizen CRL, Coley N, Moll van Charante EP, Andrieu S, Kivipelto M, Soininen H, Brayne C, Meiller Y, Richard E. 2017. PLoS ONE. 12: e0182362 A1 Journal article (refereed), original research

Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy

Sindi, Shireen; Kåreholt, Ingemar; Spulber, Gabriela; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2017. Journal of Alzheimer's disease reports. 1: 219-227 A1 Journal article (refereed), original research

Midlife work-related stress is associated with late-life cognition

Sindi S, Kåreholt I, Solomon A, Hooshmand B, Soininen H, Kivipelto M. 2017. Journal of neurology. 264: 1996-2002 A1 Journal article (refereed), original research

Mitochondrial genes are altered in blood early in Alzheimer's disease

Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Schalkwyk L, Dobson R, Malik AN, Powell J, Lovestone S, Hodges A. 2017. Neurobiology of aging. 53: 36-47 A1 Journal article (refereed), original research

New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1

Takalo Mari, Natunen Teemu, Leskelä Stina, Paldanius Kaisa MA, Soininen Hilkka, Hiltunen MIkko, Haapasalo Annakaisa. 2017. Journal of Alzheimer's disease & Parkinsonism. 7: 365 A2 Review article, Literature review, Systematic review

No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease

Lupton MK, Benyamin B, Proitsi P, Nyholt DR, Ferreira MA, Montgomery GW, Heath AC, Madden PA, Medland SE, Gordon SD, Lovestone S, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Vellas B, Powell JF, Bush AI, Wright MJ, Martin NG, Whitfield JB. 2017. Journal of Alzheimer's disease. 59: 85-99 A1 Journal article (refereed), original research

Novel genetic loci associated with hippocampal volume

Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L et al.. 2017. Nature communications. 8: 13624 A1 Journal article (refereed), original research

Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial

Lehtisalo Jenni, Ngandu Tiia, Valve Päivi, Antikainen Riitta, Laatikainen Tiina, Strandberg Timo, Soininen Hilkka, Tuomilehto Jaakko, Kivipelto Miia, Lindström Jaana. 2017. British journal of nutrition. 118: 291-302 A1 Journal article (refereed), original research

Postmenopausal hormone therapy and Alzheimer disease. A prospective cohort study

Imtiaz B, Tuppurainen M, Rikkonen T, Kivipelto M, Soininen H, Kröger H, Tolppanen A-M. 2017. Neurology. 88: 1062-1068 A1 Journal article (refereed), original research

Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers

Handels RL, Vos SJ, Kramberger MG, Jelic V, Blennow K, van Buchem M, van der Flier W, Freund-Levi Y, Hampel H, Olde Rikkert M, Oleksik A, Pirtosek Z, Scheltens P, Soininen H, Teunissen C, Tsolaki M, Wallin AK, Winblad B, Verhey FR, Visser PJ. 2017. Alzheimer's & dementia. 13: 903-912 A1 Journal article (refereed), original research

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADGC, EADI. 2017. Nature genetics. 49: 1373-1384 A1 Journal article (refereed), original research

Risk of Alzheimer's disease among users of postmenopausal hormonetherapy: A nationwide case-control study

Imtiaz B, Taipale H, Tanskanen A, Tiihonen M, Kivipelto M, Heikkinen A-M, Tiihonen J, Soininen H, Hartikainen S, Tolppanen A-M. 2017. Maturitas. 98: 7-13 A1 Journal article (refereed), original research

The Modified Frontal Behavioral Inventory (FBI-mod) for Patients with Frontotemporal Lobar Degeneration, Alzheimer's Disease, and Mild Cognitive Impairment

Suhonen NM, Hallikainen I, Hänninen T, Jokelainen J, Krüger J, Hall A, Pikkarainen M, Soininen H, Remes AM. 2017. Journal of Alzheimer's disease. 56: 1241-1251 A1 Journal article (refereed), original research

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Bos I, Vos SJ, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E, Engelborghs S, Niemantsverdriet E, De Roeck EE, Tsolaki M, Freund-Levi Y, Johannsen P, Vandenberghe R, Lleó A, Alcolea D, Frisoni GB, Galluzzi S, Nobili F et al., the Alzheimer's Disease Neuroimaging Initiative. 2017. Neurobiology of aging. 56: 33-40 A1 Journal article (refereed), original research

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. Alzheimer's research and therapy. 9: 31 A2 Review article, Literature review, Systematic review

The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals

Ferreira D, Hansson O, Barroso J, Molina Y, Machado A, Hernández-Cabrera JA, Muehlboeck J-S, Stomrud E, Nägga K, Lindberg O, Ames D, Kalpouzos G, Fratiglioni L, Bäckman L, Graff C, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H et al. and for the AddNeuroMed consortium, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), for the Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) research group. 2017. Hippocampus. 27: 653-667 A1 Journal article (refereed), original research

Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?

Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2017. World neurosurgery. 108: 356-366 A1 Journal article (refereed), original research

Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study

Jongstra Susan, Beishuizen Cathrien, Andrieu Sandrine, Barbera Mariagnese, van Dorp Matthijs, van de Groep Bram, Guillemont Juliette, Mangialasche Francesca, van Middelaar Tessa, Moll van Charante Eric, Soininen Hilkka, Kivipelto Miia, Richard Edo. 2016. Telemedicine and e-health. 2017; 23: 1-9 A1 Journal article (refereed), original research

Development of a Late-Life Dementia Prediction Index with Supervised Machine Learning in the Population-Based CAIDE Study

Pekkala Timo, Hall Anette, Lötjönen Jyrki, Mattila Jussi, Soininen Hilkka, Ngandu Tiia, Laatikainen Tiina, Kivipelto Miia, Solomon Alina. 2016. Journal of Alzheimer's disease. 2017; 55: 1055-1067 A1 Journal article (refereed), original research

Differential diagnosis of neurodegenerative diseases using structural MRI data

Koikkalainen J, Rhodius-Meester H, Tolonen A, Barkhof F, Tijms B, Lemstra AW, Tong T, Guerrero R, Schuh A, Ledig C, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, van der Flier W, Lötjönen J. 2016. Neuroimage : clinical. 11: 435-449 A1 Journal article (refereed), original research

Disrupted network topology in patients with stable and progressive mild cognitive impairment and Alzheimer's disease

Pereira Joana B, Mijalkov Mite, Kakaei Ehsan, Mecocci Patricia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Spenger Christian, Lovestone Simmon, Simmons Andrew, Wahlund Lars-Olof, Volpe Giovanni, Westman Eric, AddNeuroMed consortium, for the Alzheimer's Disease Neuroimaging Initiative. 2016. Cerebral cortex. First published online: May 13, 201: 3476-3493 A1 Journal article (refereed), original research

Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients

Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Journal of Alzheimer's disease. 2017; 55: 995-1003 A1 Journal article (refereed), original research

Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study

Imtiaz Bushra, Tolppanen Anna-Maija, Solomon Alina, Soininen Hilkka, Kivipelto Miia. 2016. Journal of Alzheimer's disease. 2017; 56: 453-458 A1 Journal article (refereed), original research

Familial idiopathic normal pressure hydrocephalus

Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Journal of the neurological sciences. 368: 11-18 A1 Journal article (refereed), original research

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology

Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B. 2016. Molecular psychiatry. [Epub ahead of print]: 1-10 A1 Journal article (refereed), original research

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ et al, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, Enigma Consortium (incl. Soininen H). 2016. Nature neuroscience. 19: 420-431 A1 Journal article (refereed), original research

Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study

Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. 2016. European journal of neurology. 24: 58-66 A1 Journal article (refereed), original research

Healthy ageing through internet counselling in the elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment

Richard Edo, Jongstra Susan, Soininen Hilkka, Brayne Carol, Moll van Charante Eric P, Meiller Yannick, van der Groep Bram, Beishuizen Cathrien RL, Mangialasche Francesca, Barbera Mariagnese, Ngandu Tiia, Coley Nicola, Guillemont Juliette, Savy Stéphanie, Dijkgraaf Marcel GW, Peters Ron JG, van Gool Willem A, Kivipelto Miia, Andrieu Sandrine. 2016. BMJ open. 6: e010806 A1 Journal article (refereed), original research

High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1

Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville. 2016. Journal of Alzheimer's disease. 52: 497-507 A1 Journal article (refereed), original research

Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning

Kulmala Jenni, Ngandu Tiia, Pajala Satu, Lehtisalo Jenni, Levälahti Esko, Antikainen Riitta, Laatikainen Tiina, Oksa Heikki, Peltonen Markku, Raurama Rainer, Soininen Hilkka, Strandberg Timo, Tuomilehto Jaakko, Kivipelto Miia. 2016. Journal of physical activity and health. 13: 1079-1087 A1 Journal article (refereed), original research

Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations

Orellana C, Ferreira D, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Wahlund LO, Westman E, AddNeuronMed consortium and for the Alzheimer''s Disease Neuroimaging Initiative. 2016. Neurodegenerative diseases. 16: 77-86 A1 Journal article (refereed), original research

Midlife work-related stress increases dementia risk in later life: the CAIDE 30-year study

Sindi Shireen, Hagman Göran, Håkansson Krister, Kulmala Jenni, Nilsen Charlotta, Kåreholt Ingemar, Soininen Hilkka, Solomon Alina, Kivipelto Miia. 2016. Journals of gerontology series b: psychological sciences and social sciences. 2017; 72: 1044-1053 A1 Journal article (refereed), original research

Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data

Halbgebauer Steffen, Nagl Magdalena, Klafki Hans, Haußmann Ute, Steinacker Petra, Oeckl Patrick, Kassubek Jan, Pinkhardt Elmar, Ludolph Albert C, Soininen Hilkka, Herukka Sanna-Kaisa, Wiltfang Jens, Otto Markus. 2016. Scientific reports. 6: 1-8 A1 Journal article (refereed), original research

Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus

Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica. 158: 2311-2319 A1 Journal article (refereed), original research

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS et al. 2016. Nature neuroscience. 19: 1569-1582 A1 Journal article (refereed), original research

SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science. 129: 2224-2238 A1 Journal article (refereed), original research

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

Lupton Michelle K, Strike Lachlan, Hansell Narelle K, Wen Wei, Mather Karen A, Armstrong Nicola J, Thalamuthu Anbupalam, McMahon Katie L, de Zubicaray Greig I, Assareh Amelia A, Simmons Andrew, Proitsi Petroula, Powell John F, Montgomery Grant W, Hibar Derrek P, Westman Eric, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Mecocci Patrizia, Velas Bruno et al, Alzheimer's Disease Neuroimaging Initiative. 2016. Neurobiology of aging. 40: 68-77 A1 Journal article (refereed), original research

Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease

Rinne JO, Wesnes K, Cummings JL, Hakulinen P, Hallikainen M, Hänninen J, Murphy M, Riordan H, Scheinin M, Soininen H, Rouru J. 2016. Alzheimer's & dementia : Translational research & clinical interventions. 2017; 3: 1-9 A1 Journal article (refereed), original research

Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease

Muñoz-Ruiz MÁ, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Husso M, Hänninen T, Vanninen R, Liu Y, Hallikainen M, Lötjönen J, Remes AM, Alafuzoff I, Soininen H, Hartikainen P. 2016. Dementia and geriatric cognitive disorders. 6: 313-329 A1 Journal article (refereed), original research

Voiko muistisairautta ehkäistä

Soininen Hilkka. 2016. Memo: muistisairaiden ihmisten hoidon ammattilehti. 1: 4-6 D1 Article in a trade journal

Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis

Beishuizen Cathrien RL, Stephan Blossom CM, van Gool Willem A, Brayne Carol, Peters Ron JG, Andrieu Sandrine, Kivipelto Miia, Soininen Hilkka, Busschers Wim B, Moll van Charante Eric P, Richard Edo. 2016. Journal of medical internet research. 18: e55 A2 Review article, Literature review, Systematic review

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Ngandu Tiia, Lehtisalo Jenni, Solomon Alina, Levälahti Esko, Ahtiluoto Satu, Antikainen Riitta, Bäckman Lars, Hänninen Tuomo, Jula Antti, Laatikainen Tiina, Lindström Jaana, Mangialasche Francesca, Paajanen Teemu, Pajala Satu, Peltonen Markku, Rauramaa Rainer, Stigsdotter-Neely Anna, Strandberg T, Tuomilehto J, Soininen Hilkka, Kivipelto Miia. 2015. The Lancet. 385: 2255-2263 A1 Journal article (refereed), original research

A Pathway based classification method for analyzing gene expression for Alzheimer's disease diagnosis

Voyle Nicola, Keohane Aoife, Newhouse Stephen, Lunnon Katie, Johnston Caroline, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Hodges Angela, Kiddle Steven, Dobson Richard JB. 2015. Journal of Alzheimer's disease. 49: 659-669 A1 Journal article (refereed), original research

Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus

Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269 A1 Journal article (refereed), original research

CSF biomarkers for the differential diagnosis of Alzheimer's disease. A large-scale international multicenter study

Ewers Michael, Mattsson Niklas, Minthon Lennart, Molinuevo José L, Antonell Anna, Popp Julius, Jessen Frank, Herukka Sanna-Kaisa, Soininen Hilkka, Maetzler Walter, Leyhe Thomas, Bürger Katharina, Taniguchi Miyako, Urakami Katsuya, Lista Simone, Dubois Bruno, Blennow Kaj, Hampel Harald. 2015. Alzheimer's & dementia. 11: 1306-1315 A1 Journal article (refereed), original research

Common genetic variants influence human subcortical brain structures

Hibar Derrek P, Stein Jason L, Renteria Miguel E, Arias-Vasquez Alejandro, Desrivières Sylvane, Jahanshad Neda, Toro Roberto, Wittfeld Katharina, Abramovic Lucija, Andersson Micael, Aribisala Benjamin S, Armstrong Nicola J, Bernard Manon, Bohlken Marc M, Boks Marco P, Bralten Janita, Brown Andrew A, Chakravarty M Mallar, Qiang Chen, Ching Christopher RK et al. (incl. Hilkka Soininen). 2015. Nature. 520: 224-229 A1 Journal article (refereed), original research

Dementia: Risk prediction models in dementia prevention

Solomon Alina, Soininen Hilkka. 2015. Nature reviews neurology. 11: 375-377 A1 Journal article (refereed), original research

Early psychosocial intervention does not delay institutionalization in persons with mild Alzheimer disease and has impact on neither disease progression nor caregivers' well-being: ALSOVA 3-year follow-up

Koivisto Anne M, Hallikainen Ilona, Välimäki Tarja, Hongisto Kristiina, Hiltunen Asta, Karppi Pertti, Sivenius Juhani, Soininen Hilkka, Martikainen Janne. 2015. International journal of geriatric psychiatry. 31(2016): 273-283 A1 Journal article (refereed), original research

Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach

Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573 A1 Journal article (refereed), original research

Feasibility of radiological markers in idiopathic normal pressure hydrocephalus

Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2015. Acta neurochirurgica. 157: 1709-1719 A1 Journal article (refereed), original research

Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study

Håkansson Krister, Soininen Hilkka, Winblad Bengt, Kivipelto Miia. 2015. PLoS ONE. 10: e0140261 A1 Journal article (refereed), original research

Generalizability of the Disease State Index Prediction Model for Identifying Patients Progressing from Mild Cognitive Impairment to Alzheimer's Disease

Hall Anette, Muñoz-Ruiz Miguel, Mattila Jussi, Koikkalainen Juha, Tsolaki Magda, Mecocci Patrizia, Kloszewska Iwona, Vellas Bruno, Lovestone Simon, Visser Pieter Jelle, Lötjonen Jyrki, Soininen Hilkka. 2015. Journal of Alzheimer's disease. 44: 79-92 A1 Journal article (refereed), original research

Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease

Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 48: 507-516 A1 Journal article (refereed), original research

Health-related quality of life in patients with idiopathic normal pressure hydrocephalus

Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 2015. European journal of neurology. published online 24 JUN 2015: 9 p A1 Journal article (refereed), original research

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Progress in neurobiology. epub ahead of print 19 May 2015: A1 Journal article (refereed), original research

Kliinis-neurofysiologiset tutkimukset

Soininen Hilkka, Partanen Juhani V. Teoksessa: Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka(toim.) , 2015. Muistisairaudet. s. 419-425. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

Khondoker Mizanur, Newhouse Stephen, Westman Eric, Muehlboeck J-Sebastian, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Lovestone Simon, Dobson Richard, Simmons Andrew, and for the AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. 2015. Journal of Alzheimer's disease. 45: 851-864 A1 Journal article (refereed), original research

Long-Term Response to Cholinesterase Inhibitor Treatment Is Related to Functional MRI Response in Alzheimer's Disease

Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. 2015. Dementia and geriatric cognitive disorders. 40: 243-255 A1 Journal article (refereed), original research

Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease

Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Dobson RJ. 2015. Journal of Alzheimer's disease. 49: 1105-1114 A1 Journal article (refereed), original research

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Steinberg Stacy, Stefansson Hreinn, Jonsson Thorlakur, Johannsdottir Hrefna, Ingason Andres, Helgason Hannes, Sulem Patrick, Magnusson Olafur Th, Gudjonsson Sigurjon A, Unnsteinsdottir Unnur, Kong Augustine, Helisalmi Seppo, Soininen Hilkka, Lah James J, DemGene, Aarsland Dag, Fladby Tormod, Ulstein Ingun D, Djurovic Srdjan, Sando Sigrid B (incl. Hiltunen Mikko). 2015. Nature genetics. 47: 445-447 A1 Journal article (refereed), original research

Midlife CAIDE Dementia Risk Score and Dementia-Related Brain Changes up to 30 Years Later on Magnetic Resonance Imaging

Vuorinen Miika, Spulber Gabriela, Soheil Damingir, Niskanen Eini, Ngandu Tiia, Soininen Hilkka, Kivipelto Miia, Soloman Alina. 2015. Journal of Alzheimer's disease. 44: 93-101 A1 Journal article (refereed), original research

Muistioireiden taudinmääritys

Soininen Hilkka, Hänninen Tuomo. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 81-89. Kustannus Oy Duodecim A3 Book section, Chapters in research books

Muistisairaudet

Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka (toim.). 2015. . 2., uudistettu painos. Kustannus Oy Duodecim C2 Edited book, conference proceedings or special issue of a journal

Muistisairaudet: käsitteitä ja termejä

Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka. Teoksessa: Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka(toim.) , 2015. Muistisairaudet. s. 18-22. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Muistisairauksien ennaltaehkäisy

Soininen Hilkka, Kivipelto Miia. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 436-445. Kustannus Oy Duodecim A3 Book section, Chapters in research books

No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease

Chiam Justin Tao Wen, Lunnon Katie, Voyle Nicola, Proitsi Petroula, Coppola Giovanni, Geschwind Daniel, Nelson Sally, Johnston Caroline, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Hodges Angela, Lovestone Simon, Newhouse Stephen, Dobson Richard James Butler, Kiddle Steven John, Sattlecker Martina. 2015. Journal of Alzheimer's disease. 47: 741-750 A1 Journal article (refereed), original research

Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation

Boccardi Marina, Bocchetta Martina, Ganzola Rossana, Rabitaille Nicholas, Redolfi Alberto, Duchesne Simon, Jack Jr. Clifford R, Frisoni Giovanni B, Bartzokis G. Csemansky JG, de Leon MJ, de Toledo-Morrell L., Killiany RJ, Lehéricy S. Malykhin N. Pantel J. Pruessner JC, Soininen H., Watson C.. 2015. Alzheimer's & dementia. 11: 184-194 A1 Journal article (refereed), original research

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease

Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Sham P, Lovestone S, Powell JF, Dobson RJB, Legido-Quigley C. 2015. Translational psychiatry. 5: e494 A1 Journal article (refereed), original research

Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

Kiddle S J, Steves C J, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton N J, Bazenet C, Killick R, Adnan J, Westman E, Nelson S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Curtis C, Breen G, Williams S C R, Lovestone S, Spector T D, Dobson R J B. 2015. Translational psychiatry. 5: e584 A1 Journal article (refereed), original research

Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment

Ferreira D, Cavallin L, Larsson E-M, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Wahlund L-O, Esteman E and for the AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. 2015. Journal of internal medicine. 278: 277-290 A1 Journal article (refereed), original research

Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index

Hall Anette, Mattila Jussi, Koikkalainen Juha, Lötjonen Jyrki, Wolz Robin, Scheltens Philip, Frisoni Giovanni, Tsolaki Magdalini, Nobili Flavio, Freund-Levi Yvonne, Minthon Lennart, Frölich Lutz, Hampel Harald, Visser Pieter Jelle, Soininen Hilkka. 2015. Current alzheimer research. 12: 69-79 A1 Journal article (refereed), original research

Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

Vos Stephanie JB, Verhey Frans, Frölich Lutz, Kornhuber Johannes, Wiltfang Jens, Maier Wolfgang, Peters Oliver, Rüther Eckart, Nobili Flavio, Morbelli Silvia, Frisoni Giovanni B, Drzezga Alexander, Didic Mira, van Berckel Bart NM, Simmons Andrew, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Muscio Cristina, Herukka Sanna-Kaisa, Salmon Eric, Bastin Christine, Wallin Anders, Nordlund Arto, de Mendonça Alexandre, Silva Dina, Santana Isabel, Lemo. 2015. Brain. 138: 1327-1338 A1 Journal article (refereed), original research

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia A Meta-analysis

Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewic. 2015. JAMA : Journal of the American Medical Association. 313: 1924-1938 A1 Journal article (refereed), original research

Protective Variant for Hippocampal Atrophy Identified by Whole Exome Sequencing

Nho Kwangsik, Kim Sungeun, Risacher Shannon L, Shen Li, Corneveaux Jason J, Swaminathan Shanker, Lin Hai, Ramanan Vijay K, Liu Yunlong, Foroud Tatiana M, Inlow Mark H, Siniard Ashley L, Reiman Rebecca A, Aisen Paul S, Petersen Ronald C, Green Robert C, Jack Jr Clifford R, Weiner Michael W, Baldwin Clinton T, Lunetta Kathryn L, Farrer Lindsay A, Furney Simon J, Lovestone Simon, Simmons Andrew, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, McDonald Brenna C, Far. 2015. Annals of neurology. 77: 547-552 A1 Journal article (refereed), original research

Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition

Ferreira Daniel, Cavallin Lena, Granberg Tobias, Lindberg Olof, Aguilar Carlos, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Lovestone Simon, Simmons Andrew, Wahlund Lars-Olof, Westman Eric for the AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. 2015. European radiology. [first online 11 Nov 2015]: 1-14 A1 Journal article (refereed), original research

Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol

Apostolova Liana G, Zarow Chris, Biado Kristina, Hurtz Sona, Boccardi Marina, Somme Johanne, Honarpisheh Hedieh, Blanken Anna E, Brook Jenny, Tung Spencer, Kraft Emily, Lo Darrick, Ng Denise, Alger Jeffry R, Vinters Harry V, Bocchetta Martina, Duvernoy Henri, R. Jack Jr Clifford R, Frisoni Giovanni B for the EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation (incl. Soininen Hilkka). 2015. Alzheimer's & dementia. 11: 139-150 A1 Journal article (refereed), original research

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205 A1 Journal article (refereed), original research

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

Marttinen Mikael, Kurkinen Kaisa MA, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Molecular neurodegeneration. 10: 12 p A2 Review article, Literature review, Systematic review

Targeting prodromal Alzheimer disease with avagacestat: a randomized clinical trial

Coric Vladimir, Salloway Stephen, van Dyck Christopher H, Dubois Bruno, Andreasen Niels, Brody Mark, Curtis Craig, Soininen Hilkka, Thein Stephen, Shiovitz Thomas, Pilcher Gary, Ferris Steven, Colby Susan, Kerselaers Wendy, Dockens Randy, Soares Holly, Kaplita Stephen, Luo Feng, Pachai Chahin, Bracoud Luc, Mintun Mark, Grill Joshua D, Marek Ken, Seibyl John, Cedarbaum Jesse M, Albright Charles, Feldman Howard H, Berman Robert M. 2015. JAMA neurology. 72: - A1 Journal article (refereed), original research

The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia

Sindi Shireen, Calov Elisabeth, Fokkens Jasmine, Ngandu Tiia, Soininen Hilkka, Tuomilehto Jaakko, Kivipelto Miia. 2015. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 1: 328-333 A1 Journal article (refereed), original research

The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects

Falahati Farshad, Ferreira Daniel, Soininen Hilkka, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Lovestone Simon, Eriksdotter Maria, Wahlund Lars-Olof, Simmons Andrew, Westman Eric; for the AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. 2015. Brain topography. 2016; 29: 296-307 A1 Journal article (refereed), original research

The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients

Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. Journal of Alzheimer's disease. 48: 959-968 A1 Journal article (refereed), original research

Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study

Zwan Marissa D, Rinne Juha O, Hasselbalch Steen G, Nordberg Agneta, Lleó Alberto, Herukka Sanna-Kaisa, Soininen Hilkka, Law Ian, Bahl Justyna MC, Carter Stephen F, Fortea Juan, Blesa Rafael, Teunissen Charlotte E, Bouwman Femke H, van Berckel Bart NM, Visser Pieter J. 2015. Neurology. 86 (2016): 50-58 A1 Journal article (refereed), original research

A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's Disease

Hartmann Tobias, van Wijk Nick, Wurtmann Richard J, Olde Rikkert Marcel GM, Sijben John WC, Soininen Hilkka, Vellas Bruno, Scheltens Philip. 2014. Journal of Alzheimer's disease. 41: 715-717 A1 Journal article (refereed), original research

Aivosairaudet ovat kalleimmat kansantautimme

Lindsberg Perttu J, Castrén Eero, Korkeila Jyrki, Alho Hannu, Erkinjuntti Timo, Isometsä Erkki, Kalso Eija, Marttunen Mauri, Pihko Helena, Tienari Pentti, Wartiovaara Anu, Jäkälä Pekka, Kälviäinen Reetta, Soininen Hilkka, Tiihonen Jari, Karlsson Hasse, Rinne Juha, Roine Risto O, Elovaara Irina, Tamminen Tuula, Öhman Juha, Majamaa Kari, Hari Riitta. 2014. Duodecim. 130: 1721-1730 A1 Journal article (refereed), original research

Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease

Proitsi P, Lupton MK, Velayudhan L, Hunter G, Newhouse S, Lin K, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Craig D, Todd S, Johnston JA, McGuinness B, Kloszewska I, Soininen H, Mecocci P, Vellas B, Passmore PA, Sims R, et al.. 2014. Neurobiology of aging. [Epub ahead of print]: x-x A1 Journal article (refereed), original research

Altered cerebrospinal fluid levels of amyloid beeta and amyloid precursor-like protein 1 peptides in Down's Syndrome

Portelius Erik, Hölttä Mikko, Soininen Hilkka, Bjerke Maria, Zetterberg Henrik, Westerlund Anni, Herukka Sanna-Kaisa, Blennow Kaj, Mattsson Niklas. 2014. Neuromolecular medicine. 16: 510-516 A1 Journal article (refereed), original research

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

Sattlecker Martina, Kiddle Steven J, Newhouse Stephen, Proitsi Petroula, Nelson Sally, Williams Stephen, Johnston Caroline, Killick Richard, Simmons Andrew, Westman Eric, Hodges Angela, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Dobson Richard JB. 2014. Alzheimer's & dementia. Epub April 2014: 1-11 A1 Journal article (refereed), original research

Alzheimer's disease-related plaques in nondemented subjects

Elobeid Adila, Rantakömi Sanna, Soininen Hilkka, Alafuzoff Irina. 2014. Alzheimer's & dementia. Epub April 2014: 1-8 A1 Journal article (refereed), original research

Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort

Aquilar C, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Wahlund L-O, Simmons A, Westman E. 2014. Frontiers in aging neuroscience. 6: 1-12 A1 Journal article (refereed), original research

Application of the PredictAD Decision Support Tool to a Danish Cohort of Patients with Alzheimer's Disease and Other Dementias

Simonsen AH, Mattila J, Hejl AM, Garde E, van Gils M, Thomsen C, Lötjönen J, Soininen H, Waldemar G. 2014. Dementia and geriatric cognitive disorders. 37: 207-213 A1 Journal article (refereed), original research

Association between mid- to late life physical fitness and dementia: evidence from the CAIDE study

Kulmala J, Solomon A, Kåreholt I, Ngandu T, Rantanen T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M. 2014. Journal of internal medicine. 276: 296-307 A1 Journal article (refereed), original research

Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts

Khan W, Westman E, Jones N, Wahlund LO, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Muehlboeck JS, Simmons A, for the AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. 2014. Brain topography. Epub: - A1 Journal article (refereed), original research

Behavioural and ERP effects of paradigm complexity on visual word recognition

Nikolaev Alexandre, Pääkkönen Ari, Niemi Jussi, Nissi Mikko J, Niskanen Eini, Könönen Mervi, Mervaala Esa, Soininen Hilkka. 2014. Language, cognition and neuroscience. 29: 1295-1310 A1 Journal article (refereed), original research

Candidate Blood Proteome Markers of Alzheimer's Disease Onset and Progression: A Systematic Review and Replication Study

Kiddle SJ, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, Nelson SK, Williams S, Hodges A, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Newhouse S, Lovestone S, Dobson RJ. 2014. Journal of Alzheimer's disease. 38: 515-531 A2 Review article, Literature review, Systematic review

Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. PLoS ONE. 9: 1-10 A1 Journal article (refereed), original research

Circulating proteomic signatures of chronological age

Menni Cristina, Kiddle Steven J, Mangino Massimo, Vinuela Ana, Psatha Maria, Steves Claire, Sattlecker Martina, Buil Alfonso, Newhouse Stephen, Nelson Sally, Williams Stephen, Voyle Nicola, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Spector Tim D, Dobson Richard, Valdes Ana M. 2014. Journals of gerontology series a: biological sciences and medical sciences. -: 1-9 A1 Journal article (refereed), original research

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones L, Lambert J, Wang L, Choi S, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards A, Bellenguez C, Ibrahim-Verbaas CA, Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis JC, Beecham GW, Grenier-Boley B, ..., Soininen H, et al., (International Genomics of Alzheimer's Disease Consortium (IGAP); International Genomics of Alzheimer's Disease Consortium IGAP). 2014. Alzheimer's & dementia. 2014: 1-14 A1 Journal article (refereed), original research

Coronary Heart Disease and Cortical Thickness, Gray Matter and White Matter Lesion Volumes on MRI

Vuorinen Miika, Damangir Soheil, Niskanen Eini, Miralbell Julia, Rusanen Minna, Spulber Gabriela, Soininen Hilkka, Kivipelto Miia, Solomon Alina. 2014. PLoS ONE. 9: e109250, 1-9 A1 Journal article (refereed), original research

Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance

Boccardi Marina, Bocchetta Martina, Apostolova Liana G, Barnes Josephine, Bartzokis George, Corbetta Gabriele, DeCarli Charles, deToledo-Morrell Leyla, Firbank Michael, Ganzola Rossana, Gerritsen Lotte, Henneman Wouter, Killiany Ronald J, Malykhin Nikolai, Pasqualetti Patrizio, Pruessner Jens C, Redolfi Alberto, Robitaille Nicolas, Soininen Hilkka et al. 2014. Alzheimer's & dementia. -: 1-13 A1 Journal article (refereed), original research

Exploring Alzheimer Molecular Pathology in Down's Syndrome Cerebrospinal Fluid

Portelius Erik, Soininen Hilkka, Andreasson Ulf, Zetterberg Henrik, Persson Rita, Karlsson Gösta, Blennow Kaj, Herukka Sanna-Kaisa, Mattsson Niklas. 2014. Neurodegenerative diseases. 14: 98-106 A1 Journal article (refereed), original research

FASTKD2 is associated with memory and hippocampal structure in older adults

Ramanan VK, Nho K, Shen L, Risacher SL, Kim S, McDonald BC, Farlow MR, Foroud TM, Gao S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, De Jager PL, Yu L, Bennett DA, Saykin AJ. 2014. Molecular psychiatry. 2014: 1-8 A1 Journal article (refereed), original research

Functional MRI in Alzheimer's Disease

Kivistö Julia, Soininen Hilkka, Pihlajamäki Maija. Teoksessa: Papageorgiou D, Christopoulos GI, Smirnakis SM(toim.) , 2014. Advanced Brain Neuroimaging Topics in Health and Disease - Methods and Applications. s. 497-519. Intech media A3 Book section, Chapters in research books

Future directions in Alzheimer's disease from risk factors to prevention

Imtiaz Bushra, Tolppanen Anna-Maija, Kivipelto Miia, Soininen Hilkka. 2014. Biochemical pharmacology. 88: 661-670 A2 Review article, Literature review, Systematic review

Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease

Escott-Price V, Bellenguez C, Wang L-S, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert J-C, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA et.al.. 2014. PLoS ONE. 9: e94661 A1 Journal article (refereed), original research

Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B; Alzheimer's Disease Neuroimaging Initiative, Williams J; GERAD1 Consortium, Stewart R, Sham P, Lovestone S, Powell JF. 2014. PLoS medicine. 11: e1001713; 1-15 A1 Journal article (refereed), original research

Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Bocchetta M, Boccardi M, Ganzola R, Apostolova LG, Preboske G, Wolf D, Ferrari C, Pasqualetti P, Robitaille N, Duchesne S, Jack CR Jr, Frisoni GB; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and the Alzheimer's Disease Neuroimaging Initiative; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and the Alzheimer's Disease Neuroimaging Initiative, Collaborators: Bartzokis G, DeCarli C, deToledo-Morrell L, Fellgiebel A, . 2014. Alzheimer's & dementia. 2014: Epub ahead of print A1 Journal article (refereed), original research

Harmonized diagnostic criteria for Alzheimer's disease: recommendations

Morris JC, Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund L-O, Dubois B. 2014. Journal of internal medicine. 275: 204-213 A1 Journal article (refereed), original research

Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study

Rusanen Minna, Kivipelto Miia, Levälahti Esko, Laatikainen Tiina, Tuomilehto Jaakko, Soininen Hilkka, Ngandu Tiia. 2014. Journal of Alzheimer's disease. 42: 183-191 A1 Journal article (refereed), original research

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641 A1 Journal article (refereed), original research

Hospital admissions, outpatient visits and healthcare costs of community-dwellers with Alzheimer's disease

Tolppanen Anna-Maija, Taipale Heidi, Purmonen Timo, Koponen Marjaana, Soininen Hilkka, Hartikainen Sirpa. 2014. Alzheimer's & dementia. 2015; 11: 955-963 A1 Journal article (refereed), original research

Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology

Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE. 3: 1-8 A1 Journal article (refereed), original research

Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells

Sutinen EM, Korolainen MA, Häyrinen J, Alafuzoff I, Petratos S, Salminen A, Soininen H, Pirttilä T, Ojala JO. 2014. Frontiers in cellular neuroscience. 8: 1-16 A1 Journal article (refereed), original research

Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort

Neuvonen Elisa, Rusanen Minna, Solomon Alina, Ngandu Tiia, Laatikainen Tiina, Soininen Hilkka, Kivipelto Miia, Tolppanen Anna-Maija. 2014. Neurology. 82: 2205-2212 A1 Journal article (refereed), original research

Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

Tolppanen Anna-Maija, Solomon Alina, Kulmala Jenni, Kåreholt Ingemar, Ngandu Tiia, Rusanen Minna, Laatikainen Tiina, Soininen Hilkka, Kivipelto Miia. 2014. Alzheimer's & dementia. Epub ahead of print: - A1 Journal article (refereed), original research

Modifiable lifestyle factors in dementia: A systematic review of longitudinal observational cohort studies

Di Marco Luigi Yuri, Marzo Alberto, Munoz-Ruiz Miguel, Arfan Ikram M, Kivipelto Miia, Ruefenacht Daniel, Venneri Annalena, Soininen Hilkka, Wanke Isabel, Ventikos Yiannis A, Frangi Alejandro F. 2014. Journal of Alzheimer's disease. 42: 119-135 A1 Journal article (refereed), original research

Oophorectomy, Hysterectomy, and Risk of Alzheimer's Disease: A Nationwide Case-Control Study

Imtiaz Bushra, Tuppurainen Marjo, Tiihonen Miia, Kivipelto Miia, Soininen Hilkka, Hartikainen Sirpa, Tolppanen Anna-Maija. 2014. Journal of Alzheimer's disease. 42: 575-581 A1 Journal article (refereed), original research

Plasma proteins predict conversion to dementia from prodromal disease

Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H et.al.. 2014. Alzheimer's & dementia. -: 1-9 A1 Journal article (refereed), original research

Predicting progression of Alzheimer's Disease using ordinal regression

Doyle OM, Westman E, Marquand AF, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Williams SCR, Simmons A. 2014. PLoS ONE. 9: e105542 A1 Journal article (refereed), original research

Prognostic polypeptide blood plasma biomarkers of Alzheimer's Disease progression

Yang Hongqian, Lyutvinskiy Yaroslav, Herukka Sanna-Kaisa, Soininen Hilkka, Rutishauser Dorothea, Zubarev Roman A. 2014. Journal of Alzheimer's disease. 40: 659-666 A1 Journal article (refereed), original research

Random Forest ensembles for detection and prediction of Alzheimer's disease with a good between-cohort robustness

Lebedev AV, Westman E, Van Westen GJ, Kramberger MG, Lundervold A, Aarsland D, Soininen H, KLoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Simmons A, for the Alzheimer's Disease Neuroimaging Initiative and the AddNeuroMed consortium. 2014. Neuroimage : clinical. 6: 115-125 A1 Journal article (refereed), original research

Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial

Ngandu Tiia, Lehtisalo Jenni, Levälahti Esko, Laatikainen Tiina, Lindström Jaana, Peltonen Markku, Solomon Alina, Ahtiluoto Satu, Antikainen Riitta, Hänninen Tuomo, Jula Antti, Mangialasche Francesca, Paajanen Teemu, Pajala Satu, Rauramaa Rainer, Strandberg Timo, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. 2014. International journal of environmental research and public health. 11: 9345-9360 A1 Journal article (refereed), original research

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C, Apostolova LG, ..., Soininen H, et al.. 2014. Alzheimer's & dementia. 11: 111-125 A1 Journal article (refereed), original research

The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients

Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. Neurodegenerative diseases. 14: 204-208 A1 Journal article (refereed), original research

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28 A1 Journal article (refereed), original research

A blood gene expression marker of early Alzheimer's Disease

Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H et.al.. 2013. Journal of Alzheimer's disease. 33: 737-753 A1 Journal article (refereed), original research

Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood

Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A. 2013. Neurobiology of aging. [Epub ahead of print]: 1-12 A1 Journal article (refereed), original research

Alzheimern taudin uudet riskigeenit - tautia ennakoivat biomarkkerit?

Hiltunen M, Haapasalo A, Soininen H. 2013. Duodecim. 129: 583-588 A2 Review article, Literature review, Systematic review

An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment

Spulber G, Simmons A, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Wahlund L-O, Westman E. 2013. Journal of internal medicine. 273: 396-409 A1 Journal article (refereed), original research

Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study

Chincarini Andres, Bosco Paolo, Gemme Gianluca, Esposito Mario, Rei Luca, Squarcia Sandro, Bellotti Roberto, Minthon Lennart, Frisoni Giovanni, Scheltens Philip, Frölich Lutz, Soininen Hilkka, Visser Pieter-Jelle, Nobili Flavio. 2013. Alzheimer's & dementia. [Epub ahead of print]: 1-12 A1 Journal article (refereed), original research

CERAD neuropsychological compound scores are accurate in detecting prodromal Alzheimer's Disease: A prospective AddNeuroMed Study

Paajanen T, Hänninen T, Tunnard C, Hallikainen M, Mecocci P, Sobow T, Tsolaki M, Vellas B, Lovestone S, Soininen H. 2013. Journal of Alzheimer's disease. -: - A1 Journal article (refereed), original research

CERAD neuropsychological total score reflect cortical thinning in prodromal Alzheimer's Disease

Paajanen T, Hänninen T, Aitken A, Hallikainen M, Westman E, Wahlund L-O, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H.. 2013. Dementia and geriatric cognitive disorders. 3: 446-458 A1 Journal article (refereed), original research

Changes in vascular factors 28 years from midlife and late-life cortical thickness

Vuorinen M, Kåreholt I, Julkunen V, Spulber G, Niskanen E, Paajanen T, Soininen H, Kivipelto M, Solomon A. 2013. Neurobiology of aging. 34: 100-109 A1 Journal article (refereed), original research

Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study

Rusanen M, Ngandu T, Laatikainen T, Tuomilehto J, Soininen H, Kivipelto M. 2013. Current alzheimer research. 10: 549-555 A1 Journal article (refereed), original research

Classification Models for Alzheimer's Disease Detection

Anagnostopoulos C-N, Giannoukos J, Spenger C,Simmons A, Mecocci P, Soininen H, Kloszewska I, Vellas B, Lovestone S, Tsolaki M. Teoksessa: Iliadis L, Papadopoulos H, Jayne C(toim.) , 2013. Engineering Applications of Neural Networks. s. 193-202. A4 Conference proceedings

Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of alpha-/gamma-tocotrienols and gamma-tocopherol

Mangialasche F, Westman E, Kivipelto M, Muehlboeck J-S, Cecchetti R, Baglioni M, Tarducci R, Gobbi G, Floridi P, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Spenger C, Lovestone S, Wahlund L-O, Simmons A, Mecocci P. 2013. Journal of internal medicine. 273: 602-621 A1 Journal article (refereed), original research

Clinical symptoms and symptom signatures of Alzheimer's Disease subgroups

Iqbal Khalid, Flory Michael, Soininen Hilkka. 2013. Journal of Alzheimer's disease. 37: 475-481 A1 Journal article (refereed), original research

Comparing Predictors of Conversion to Alzheimer's Disease Using the Disease State Index

Muñoz-Ruiz MA, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Neurodegenerative diseases. epub ahead of print: 3 sivua A1 Journal article (refereed), original research

Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment

Aguilar C, Westman E, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Spenger C, Simmons A, Wahlund L-O. 2013. Psychiatry research: neuroimaging. 212: 89-98 A1 Journal article (refereed), original research

Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's Disease and mild cognitive impairment

Munoz-Ruiz MA, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Journal of Alzheimer's disease. 35: 727-739 A1 Journal article (refereed), original research

Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease

Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700 A1 Journal article (refereed), original research

Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease

Natunen T, Parrado AR, Helisalmi S, Pursiheimo J-P, Sarajärvi T, Mäkinen P, Kurkinen KMA, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Journal of Alzheimer's disease. 37: 217-232 A1 Journal article (refereed), original research

Entorhinal cortex thickness predicts cognitive decline in Alzheimer's Disease

Velayudhan L, Proitsi P, Westman E, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Hodges A, Powell J, Lovestone S, Simmons A. 2013. Journal of Alzheimer's disease. 33: 755-766 A1 Journal article (refereed), original research

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

Whiley Luke, Sen Arundhuti, Heaton James, Proitsi Petroula, Garcia-Gomez Diego, Leung Rufina, Smith Norman, Thambisetty Madhav, Kloszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Legido-Quigley C. 2013. Neurobiology of aging. x: 1-8 A1 Journal article (refereed), original research

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients

Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. Journal of Alzheimer's disease. 33: 23-27 A1 Journal article (refereed), original research

Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort

Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. PLoS ONE. 8: e59676 A1 Journal article (refereed), original research

History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study

Tolppanen Anna-Maija, Lavikainen Piia, Solomon Alina, Kivipelto Miia, Uusitupa Matti, Soininen Hilkka, Hartikainen Sirpa. 2013. Diabetes care. 36: 2015-2019 A1 Journal article (refereed), original research

Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics

Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH... Soininen H et al.. 2013. Molecular psychiatry. 18: 739 A1 Journal article (refereed), original research

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Progress in neurobiology. 106-107: 33-54 A1 Journal article (refereed), original research

Incidence of stroke in people with Alzheimer disease. A national register-based approach

Tolppanen Anna-Maija, Lavikainen Piia, Solomon Alina, Kivipelto Miia, Soininen Hilkka, Hartikainen Sirpa. 2013. Neurology. 80: 353-358 A1 Journal article (refereed), original research

Incident Hip Fractures among Community Dwelling Persons with Alzheimer's Disease in a Finnish Nationwide Register-Based Cohort

Tolppanen A-M, Lavikainen P, Soininen H, Hartikainen S. 2013. PLoS ONE. 8: e59124 A1 Journal article (refereed), original research

Incident ischaemic heart disease in persons with Alzheimer's disease in a Finnish nationwide exposure-matched cohort

Tolppanen Anna-Maija, Kettunen Raimo, Ahonen Riitta, Soininen Hilkka, Hartikainen Sirpa. 2013. International journal of cardiology. 170: 195-201 A1 Journal article (refereed), original research

Inflammatory proteins in plasma are associated with severity of Alzheimer's Disease

Leung R, Proitsi P, Simmons A, Lunnon K, Guntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Soininen H, Wahlund L-O, Lovestone S. 2013. PLoS ONE. 8: e64971 A1 Journal article (refereed), original research

Influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs

Pereira JB, Cavallin L, Spulber G, Aguilar C, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Aarsland D, Lovestone S, Simmons A, Wahlund L-O, Westman E. 2013. Journal of internal medicine. -: - A1 Journal article (refereed), original research

Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

Clerx L, van Rossum IA, Burns L, Knol DL, Scheltens P, Verhey F, Aalten P, Lapuerta P, van de Pol L, van Schijndel R, de Jong R, Barkhof F, Wolz R, Rueckert D, Bocchetta M, Tsolaki M, Nobili F, Wahlund L-O, Minthon L, Frölich L, Hampel H, Soininen H, Jelle Visser P. 2013. Neurobiology of aging. 34: 2003-2013 A1 Journal article (refereed), original research

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Lambert JC,Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, ... Soininen H, ... Hiltunen M et al.. 2013. Nature genetics. Dec; 45 (12): 1452-8 A1 Journal article (refereed), original research

Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort

Tolppanen A-M, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, Kivipelto M. 2013. Journal of Alzheimer's disease. online: - A1 Journal article (refereed), original research

Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus

Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,. 2013. Neurosurgery. 72: 1-8 A1 Journal article (refereed), original research

Predicting AD conversion: Comparison between prodromal AD guidelines and computer assisted PredictAD tool

Liu Y, Mattila J, Muñoz Ruiz MA, Paajanen T, Koikkalainen J, van Gils M, Herukka S-K, Waldemar G, Lötjönen J, Soininen H. 2013. PLoS ONE. 8: e55246 A1 Journal article (refereed), original research

Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI

Voss SJB, van Rossum IA, Verhey F, Knol DL, Soininen H, Wahlund L-O, Hampel H, Tsolaki M, Minthon L, Frisoni GB, Froelich L, Nobili F, van der Flier W, Blennow K, Wolz R, Scheltens P, Visser PJ. 2013. Neurology. 80: 1124-1132 A1 Journal article (refereed), original research

Prevention of Alzheimer's Disease: Moving backward through the lifespan

Solomon A, Kivipelto M, Soininen H. 2013. Journal of Alzheimer's disease. 33: S465-S469 A2 Review article, Literature review, Systematic review

Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study

Hallikainen I, Hänninen T, Fraunberg M, Hongisto K, Välimäki T, Hiltunen A, Karppi P, Sivenius J, Soininen H, Koivisto AM. 2013. International psychogeriatrics. 25: 1335-1344 A1 Journal article (refereed), original research

Protein aggregation and degradation mechanisms in neurodegenerative diseases

Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A. 2013. American journal of neurodegenerative disease. 2: 1-14 A2 Review article, Literature review, Systematic review

Quantitative evaluation of disease progression in a longitudinal mild cognitive impairment cohort

Runtti H, Mattila J, van Gils M, Koikkalainen J, Soininen H. 2013. Journal of Alzheimer's disease. -: - A1 Journal article (refereed), original research

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's Disease patients alter calcium homeostasis

Rubio-Moscardo Fanny, Seto-Salvia Nuria, Pera Marta, Bosch-Morato Monica, Plata Christina, Belbin Olivia, Gene Gemma, Dols-Icardo Oriol, Ingelsson Martin, Helisalmi Seppo, Soininen Hilkka, Hiltunen Mikko, Giedraitis Vilmantas, Lannfelt Lars, Frank Ana, Bullido Ma Jesus, Combarros Onofre, Sanchez-Juan Pascual et.al.. 2013. PLoS ONE. 8: e74203 A1 Journal article (refereed), original research

Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults

Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. 2013. Experimental gerontology. 48: 1428-1435 A1 Journal article (refereed), original research

Single-domain amnestic mild cognitive impairment identified by Cluster analysis predicts Alzheimer's Disease in the European Prospective DESCRIPA Study

Damian M, Hausner L, Jekel K, Richter M, Froelich L, Almkvist O, Boada M, Bullock R, De Deyn PP, Frisoni GB, Hampel H, Jones RW, Kehoe P, Lenoir H, Minthon L, Olde Rikkert MGM, Rodriguez G, Scheltens P, Soininen H, Luizaa Spiru et.al.. 2013. Dementia and geriatric cognitive disorders. 36: 1-19 A1 Journal article (refereed), original research

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 781-794 A1 Journal article (refereed), original research

Targeting ubiquilin-1 in Alzheimer's disease

Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KMA, Tanzi RE, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 795-810 A2 Review article, Literature review, Systematic review

The Finnish Geriatric intervention study to prevent cognitive impairment and disability (FINGER): Study design and progress

Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. 2013. Alzheimer's & dementia. 9: 657-665 A1 Journal article (refereed), original research

The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease

Antila K, Lötjönen J, Thurfjell L, Laine J, Massimini M, Rueckert D, Zubarev RA, Oresic M, van Gils M, Mattila J, Hviid Simonsen A, Waldemar G, Soininen H. 2013. Interface focus. 6 April 2013 vol. 3: 20120072 A1 Journal article (refereed), original research

The association between APOE epsilon4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA study

Vermeiren APA, Bosma H, Visser P-J, Zeegers MP, Graff C, Ewers M, Frisoni GB, Frölich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili FM, Olde Rikkert M, Rigaud A-S, Scheltens P, Soininen H, Spiru L, Tsolaki M, Wahlund L-O et.al.. 2013. Journal of Alzheimer's disease. 35: 241-246 A1 Journal article (refereed), original research

Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells

Viswanathan J, Haapasalo A, Kurkinen KMA, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Biochemistry. 52: 3899-3912 A1 Journal article (refereed), original research

Validity of dementia and Alzheimer disease diagnoses in Finnish national registers

Solomon A, Ngandu T, Soininen H, Hallikainen M, Kivipelto M, Laatikainen T. 2013. Alzheimer's & dementia. Epub: 1-7 A1 Journal article (refereed), original research

Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H et.al.. 2013. Molecular psychiatry. -: 1-7 A1 Journal article (refereed), original research

APOE4 predicts amyloid-&#946 in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. Journal of neurology neurosurgery and psychiatry. 83: 1119-1124 A1 Journal article (refereed), original research

Alzheimer's Disease

Pihlajamäki M, Soininen H. Teoksessa: Bartsch T(toim.) , 2012. The Clinical Neurobiology of the Hippocampus. s. 223-244. Oxford University Press A3 Book section, Chapters in research books

Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation

Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, Pritchard M, Lord K, Martin BM, Craig D, Todd S, McGuinness B, Hollingworth P, Harold D, Kloszewska I, Soininen H, Mecocci P, Velas B, Gill M, Lawlor B, Rubinsztein DC, Brayne C, Passmore PA, Williams J, Lovestone S, Powell JF. 2012. Neurobiology of aging. 33: 1843.e9-1843.e17 A1 Journal article (refereed), original research

Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

Greco I, Day N, Riddoch-Contreras J, Reed J, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Spenger C, Mecocci P, Wahlund L-O, Simmons A, Barnes J, Lovestone S. 2012. Journal of translational medicine. 10: 217 A1 Journal article (refereed), original research

Alzheimerin taudin perustutkimuksesta uusiin lääkehoitoihin [with English Summary: From basic research towards novel therapies in Alzheimer's disease]

Hiltunen Mikko, Hallikainen Merja, Haapasalo Annakaisa, Soininen Hilkka. 2012. Dosis. 28: 25-31 A2 Review article, Literature review, Systematic review

Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment

Ramakers IHGB, Verhey FRJ, Scheltens P, Hampel H, Soininen H, Aalten P, Olde Rikkert M, Verbeek MM, Spiru L, Blennow K, Trojanowski JQ, Shaw LM, Visser PJ. 2012. Psychological medicine. -: 1-10 A1 Journal article (refereed), original research

Application of the PredictAD software tool to predict progression in patients with mild cognitive impairment

Simonsen AH, Mattila J, Hejl A-M, Frederiksen KS, Herukka S-K, Hallikainen M, van Gils M, Lötjönen J, Soininen H, Waldemar G. 2012. Dementia and geriatric cognitive disorders. 34: 344-350 A1 Journal article (refereed), original research

Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study

Hooshmand B, Solomon A, Kåreholt I, Rusanen M, Hänninen T, Leivistä J, Winblad B, Laatikainen T, Soininen H, Kivipelto M. 2012. Journal of internal medicine. 271: 204-212 A1 Journal article (refereed), original research

Bepridil decreases A&#946 and calcium levels in the thalamus after middle cerebral artery occlusion in rats

Sarajärvi Timo, Lipsanen Anu, Mäkinen Petra, Peräniemi Sirpa, Soininen Hilkka, Haapasalo Annakaisa, Jolkkonen Jukka, Hiltunen Mikko. 2012. Journal of cellular and molecular medicine. 16: 2754-2767 A1 Journal article (refereed), original research

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology. 78: 1568-1575 A1 Journal article (refereed), original research

Cognitive and neuropsychiatric symptom differences in early stages of Alzheimer's Disease: Kuopio ALSOVA Study

Hallikainen I, Koivisto AM, Paajanen T, Hiltunen A, Karppi P, Vanhanen M, Välimäki T, Herukka S-K, Soininen H, Hänninen T. 2012. Dementia and geriatric cognitive disorders. 2: 209-218 A1 Journal article (refereed), original research

Combination of biomarkers: PET [18F]Flutemetamol imaging and structural MRI in Dementia and mild cognitive impairment

Thurfjell L, Lötjönen J, Lundqvist R, Koikkalainen J, Soininen H, Waldemar G, Brooks DJ, Vandenberghe R. 2012. Neurodegenerative diseases. 10: 246-249 A1 Journal article (refereed), original research

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Journal of cellular and molecular medicine. 16: 1206-1222 A1 Journal article (refereed), original research

Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus

Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. 2012. Neurodegenerative diseases. 10: 166-169 A1 Journal article (refereed), original research

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's Disease Dementia

Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka S-K, Steinacker P, Tawfik S, Tumani H, von Arnim CSF, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M. 2012. PLoS ONE. 7: e48783 A1 Journal article (refereed), original research

Education increases reserve against Alzheimer's disease - evidence from structural MRI analysis

Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund L-O, Aitken A, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H. 2012. Neuroradiology. 54: 929-938 A1 Journal article (refereed), original research

Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer's Disease

Dubois B, Zaim M, Touchon J, Vellas B, Robert P, Murphy MF, Pujadas-Navines F, Rainer M, Soininen H, Riordan HJ, Kanony-Truc C. 2012. Journal of Alzheimer's disease. 29: 527-535 A1 Journal article (refereed), original research

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Progress in neurobiology. 96: 87-95 A1 Journal article (refereed), original research

Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD

Spulber G, Niskanen E, MacDonald S, Kivipelto M, Ferreira Padilla D, Julkunen V, Hallikainen M, Vanninen R, Wahlund L-O, Soininen H. 2012. Current alzheimer research. 9: 516-524 A1 Journal article (refereed), original research

Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease

Whitehead D, Tunnard C, Hurt C, Wahlund LO, Mecocci P, Tsolaki M, Vellas B, Spenger C, Kloszewska I, Soininen H, Cromb D, Lovestone S, Simmons A. 2012. International psychogeriatrics. 24: 99-107 A1 Journal article (refereed), original research

Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease

Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Journal of Alzheimer's disease. 28: 553-559 A1 Journal article (refereed), original research

Genetics of Alzheimer's disease

Viswanathan J, Soininen H, Hiltunen M. Teoksessa: Gauthier S, Rosa-Neto P(toim.) , 2012. Advances in Alzheimer's Disease Management. s. 2-9. A3 Book section, Chapters in research books

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C et al.. 2012. Molecular psychiatry. -: - A1 Journal article (refereed), original research

Hippocampal atrophy in Alzheimer's disease

Soininen H, Liu Y, Rueckert D, Lötjönen J. 2012. Neurodegenerative disease management. 2: 197-209 A2 Review article, Literature review, Systematic review

Hyperphosphorylated tau in young and middle-aged subjects

Elobeid A, Soininen H, Alafuzoff I. 2012. Acta neuropathologica. 123: 97-104 A1 Journal article (refereed), original research

Identification of cis-regulatory variation influencing protein abundance levels in human plasma

Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S, Dobson R. 2012. Human molecular genetics. 21: 3719-3726 A1 Journal article (refereed), original research

Improved classification of Alzheimer's Disease data via removal of nuisance variability

Koikkalainen J, Pölönen H, Mattila J, van Gils M, Soininen H, Lötjönen J. 2012. PLoS ONE. 7: e31112 A1 Journal article (refereed), original research

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

van Rossum IA, Bos SJB, Burns L, Knol DL, Scheltens P, Soininen H, Wahlund L-O, Hampel H, Tsolaki M, Minthon L, L'Italien G, van der Flier WM, Teunissen CE, Blennow K, Barkhof F, Rueckert D, Wolz R, Verhey F, Visser PJ. 2012. Neurology. 79: 1809-1816 A1 Journal article (refereed), original research

Midlife Vascular Risk Factors and Alzheimer's Disease: Evidence from Epidemiological Studies

Tolppanen AM, Solomon A, Soininen H, Kivipelto M. 2012. Journal of Alzheimer's disease. 32: 531-40 A2 Review article, Literature review, Systematic review

Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: A population-based study

Wallin K, Solomon A, Kåreholt I, Tuomilehto J, Soininen H, Kivipelto M. 2012. Journal of Alzheimer's disease. 31: 669-676 A1 Journal article (refereed), original research

Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses

Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Journal of nutrition health and aging. 16: 631-635 A1 Journal article (refereed), original research

Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's Disease blood

Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A, on behalf of the AddNeuroMed Consortium. 2012. Journal of Alzheimer's disease. 30: 685-710 A1 Journal article (refereed), original research

Optimizing the diagnosis of early Alzheimer's Disease in mild cognitive impairment subjects

Mattila J, Soininen H, Koikkalainen J, Rueckert D, Wolz R, Waldemar G, Lötjönen J. 2012. Journal of Alzheimer's disease. 32: 969-979 A1 Journal article (refereed), original research

Plasma based markers of [11C] PiB-PET brain amyloid burden

Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R. 2012. PLoS ONE. 7: e44260 A1 Journal article (refereed), original research

Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature

Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. 2012. Neuropathology and applied neurobiology. 38: 72-86 A1 Journal article (refereed), original research

Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer Disease

Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G, Colby S, Rollin L, Dockens R, Pachai C, Portelius E, Andreasson U, Blennow K, Soares H, Albright C, Feldman HH, Berman RM. 2012. Archives of neurology. 69: 1430-1440 A1 Journal article (refereed), original research

Sensorimotor, visual, and auditory cortical atrophy in Unverricht-Lundborg Disease mapped with cortical thickness analysis

Koskenkorva P, Niskanen E, Hyppönen J, Könönen M, Mervaala E, Soininen H, Kälviäinen R, Vanninen R. 2012. American journal of neuroradiology. 33: 878-883 A1 Journal article (refereed), original research

Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry

Munoz-Ruiz MA, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka S-K, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H. 2012. PLoS ONE. 7: e52531 A1 Journal article (refereed), original research

TREM2 Variants in Alzheimer's Disease

Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JSK, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert J-C, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St. George-Hyslop P, Singleton A, Hardy J, for the Alzheimer Genetic Analysis Group, Soininen H.... 2012. The new england journal of medicine. -: 1-11 A1 Journal article (refereed), original research

Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI

Vos S, van Rossum I, Burns L, Knol D, Scheltens P, Soininen H, Wahlund L-O, Hampel H, Tsolaki M, Minthon L, Handels R, Italien GL, van der Flier W, Aalten P, Teunissen C, Barkhof F, Blennow K, Wolz R, Rueckert D, Verhey F, Visser PJ. 2012. Neurobiology of aging. 33: 2272-2281 A1 Journal article (refereed), original research

The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent

Jacobs HIL, Visser PJ, Van Boxtel MPJ, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund L-O, Minthon L, Frölich L, Hampel H, Soininen H, van de Pol L, Scheltens P, Tan FES, Jolles J, Verhey FRJ. 2012. Neurobiology of aging. 33: 201.e1-201.e8 A1 Journal article (refereed), original research

Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P. 2012. Neurobiology of aging. 33: 2282-2290 A1 Journal article (refereed), original research

Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions

Hartikainen PH, Pikkarainen M, Hänninen T, Soininen H, Alafuzoff I. 2012. Neuropathology. 32: 60-68 A1 Journal article (refereed), original research

Voiko muistisairauksia ehkäistä?

Kivipelto M, Ngandu T, Soininen H, Laatikainen T. Teoksessa: Reivinen J, Vähäkylä L(toim.) , 2012. Kansan terveys, yksilön hyvinvointi. s. 91-107. Gaudeamus Oy D2 Article in a professional book (incl. an introduction by the editor)

iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia

Lehnert S, Jesse S, Rist W, Steinacker P, Soininen H, Herukka S-K, Tumani H, Lenter M, Oeckl P, Ferger B, Hengerer B, Otto M. 2012. Experimental neurology. 234: 499-505 A1 Journal article (refereed), original research

A Disease State Fingerprint for Evaluation of Alzheimer's Disease

Mattila J, Koikkalainen J, Virkki A, Simonsen A, van Gils M, Waldemar G, Soininen H, Lötjönen J. 2011. Journal of Alzheimer's disease. 27: 163-176 A1 Journal article (refereed), original research

AMP-activated protein kinase: a potential player in Alzheimer's disease

Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of neurochemistry. 118: 460-474 A1 Journal article (refereed), original research

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fievet N, Brouwers N, Bettens K, Arosio B, Coto E, Del Zompo M, Mateo I, Epelbaum J, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Valdivieso F, Vepsäläinen S et al.. 2011. Molecular psychiatry. 16: 903-907 A1 Journal article (refereed), original research

AddNeuroMed and ADNI: Similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America

Westman E, Simmons A, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Weiner MW, Lovestone S, Spenger C, Wahlund L-O. 2011. Neuroimage. 58: 818-828 A1 Journal article (refereed), original research

Age-related macular degeneration (AMD): Alzheimer's Disease in the eye

Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of Alzheimer's disease. 24: 615-631 A2 Review article, Literature review, Systematic review

Alzheimer's Disease and mild cognitive impairment are associated with elevated levels of isoaspartyl residues in blood plasma proteins

Yang H, Lyutvinskiy Y, Soininen H, Zubarev RA. 2011. Journal of Alzheimer's disease. 27: 113-118 A1 Journal article (refereed), original research

Alzheimer's disese-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

Viswanathan Jayashree, Haapasalo Annakaisa, Böttcher Claudia, Miettinen Riitta, Kurkinen Kaisa MA, Lu Alice, Thomas Anne, Maynard Christa J, Romano Donna, Hyman Bradley T, Berezovska Oksana, Bertram Lars, Soininen Hilkka, Dantuma Nico P, Tanzi RE, Hiltunen Mikko. 2011. Traffic. 12: 330-348 A1 Journal article (refereed), original research

Apathy and cortical atrophy in Alzheimer's disease

Tunnard C, Whitehead D, Hurt C, Wahlund LO, Mecocci P, Tsolaki M, Vellas B, Spenger C, Kloszewska I, Soininen H, Lovestone S, Simmons A. 2011. International journal of geriatric psychiatry. 26: 741-748 A1 Journal article (refereed), original research

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. European journal of neuroscience. 34: 3-11 A2 Review article, Literature review, Systematic review

Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment

Costafreda Sergi G, Dinov Ivo D, Tu Zhuowen, Shi Yonggang, Liu Cheng-Yi, Kloszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Wahlund Lars-Olof, Spenger Christian, Toga Arthur W, Lovestone Simon, Simmons Andrew. 2011. Neuroimage. 56: 212-219 A1 Journal article (refereed), original research

CERAD-neuropsychological battery in screening mild Alzheimer's disease

Sotaniemi M, Pulliainen V, Hokkanen L, Pirttilä T, Hallikainen I, Soininen H, Hänninen T. 2011. Acta neurologica scandinavica. doi:10.1111/j.1439-0272.2010.01459.: 1-8 A1 Journal article (refereed), original research

Changes in vascular risk factors from midlife to late life and white matter lesions: A 20-year follow-up study

Vuorinen Miika, Solomon Alina, Rovio Suvi, Nieminen Lasse, Kåreholt Ingemar, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. 2011. Dementia and geriatric cognitive disorders. 31: 119-125 A1 Journal article (refereed), original research

Characterization of a novel transgenic rat carrying human tau with mutation P301L

Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen M-L, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H. 2011. Neurobiology of aging. 32: 2314-2315 A1 Journal article (refereed), original research

Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups - The AddNeuroMed study

Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H. 2011. Neurobiology of aging. 32: 1198-1206 A1 Journal article (refereed), original research

Combinatorial markers of mild cognitive impairment conversion to Alzheimer's Disease - cytokines and MRI measures together predict disease progression

Furney SJ, Kronenberg D, Simmons A, Guntert A, Dobson RJ, Proitsi P, Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lovestone S. 2011. Journal of Alzheimer's disease. 26: 395-405 A1 Journal article (refereed), original research

Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's Disease

Julkunen P, Jauhiainen AM, Könönen M, Pääkkönen A, Karhu J, Soininen H. 2011. International journal of alzheimers disease. 2011: 1-9 A1 Journal article (refereed), original research

Common variants at ABCA7,MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J et al.. 2011. Nature genetics. 43: 429-435 A2 Review article, Literature review, Systematic review

Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking

Sarajärvi Timo, Tuusa Jussi T, Haapasalo Annakaisa, Lackman Jarkko T, Sormunen Raija, Helisalmi Seppo, Roehr Johannes T, Parrado Antonio R, Mäkinen Petra, Bertram Lars, Soininen Hilkka, Tanzi Rudolph E, Petäjä-Repo Ulla E, Hiltunen Mikko. 2011. Molecular and cellular biology. 31: 2326-2340 A1 Journal article (refereed), original research

Deep sequencing of the nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease

Lupton Michell K, Proitsi Petroula, Danillidou Makrina, Tsolaki Magda, Hamilton Gillian, Wroe Richard, Pritchard Megan, Lord Kathryn, Martin Belinda M, Kloszewska Iwona, Soininen Hilkka, Mecocci Patrizia, Vellas Bruno, Harold Denise, Hollingworth Paul, Lovestone Simon, Powell John F. 2011. PLoS ONE. 6: e17298 A1 Journal article (refereed), original research

Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment

Liu Y, Spulber G, Lehtimäki KK, Könönen M, Hallikainen I, Gröhn H, Kivipelto M, Hallikainen M, Vanninen R, Soininen H. 2011. Neurobiology of aging. 32: 1558-1571 A1 Journal article (refereed), original research

Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar Ataxia as assessed by p62/Sequestosome immunohistochemistry

Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I. 2011. Cerebellum. 10: 720-731 A1 Journal article (refereed), original research

Do instrumental activities of daily living predict dementia at 1- and 2-year follow-up? Findings from the development of screening guidelines and diagnostic criteria for predementia Alzheimer's Disease Study

Sikkes SAM, Visser PJ, Knol DL, de Lange-de-Klerk ESM, Tsolaki M, Frisoni GB, Nobili F, Spiru L, Rigaud AS, Frölich L, Olde Rikkert M, Soininen H, Touchon J, Wilcock G, Boada M, Hampel H, Bullock R, Vellas B, Pijnenburg YAL, Scheltens P, Verhey FR, Uitdehaag BMJ. 2011. Journal of the american geriatrics society. 59: 2273-2281 A1 Journal article (refereed), original research

Effect of cholinergic stimulation in early Alzheimer's Disease - Functional imaging during a recognition memory task

Miettinen PS, Pihlajamäki M, Jauhiainen AM, Tarkka IM, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. 2011. Current alzheimer research. 8: 753-764 A1 Journal article (refereed), original research

Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease

Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Progress in neurobiology. 96: 87-95 A1 Journal article (refereed), original research

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

Lambert J, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, Tognoni G, Fievet N, Boland A, Arosio B, Coto E, Del Zompo M, Mateo I, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri F, Delepine M et al.. 2011. Neurobiology of aging. 32: 756.e11-756.e15 A1 Journal article (refereed), original research

Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease

Lötjönen Jyrki, Wolz Robin, Koikkalainen Juha, Julkunen Valtteri, Thurfjell Lennart, Lundqvist Roger, Waldemar Gunhild, Soininen Hilkka, Rueckert Daniel. 2011. Neuroimage. 56: 185-196 A1 Journal article (refereed), original research

Improved generation of probabilistic atlases for the expectation maximization classification

Lötjönen Jyrki, Wolz Robin, Koikkalainen Juha, Thurfjell Lennart, Lundqvist Roger, Waldemard Gunhild, Soininen Hilkka, Rueckert Daniel. Teoksessa: Wright S, Pan X, Liebling M (Eds)(toim.) , 2011. Proceedings - International Symposium on Biomedical Imaging. s. 1839-1842. IEEE A4 Conference proceedings

Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation

Haapasalo A, Viswanathan J, Kurkinen KMA, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. 2011. Communicative & integrative biology. 4: 428-432 A1 Journal article (refereed), original research

Longitudinal changes of CSF biomarkers in Alzheimer's Disease

Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka S-K. 2011. Journal of Alzheimer's disease. 25: 583-594 A1 Journal article (refereed), original research

Metabolome in progression to Alzheimer's disease

Oresic M, Hyötyläinen T, Herukka S-K, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H. 2011. Translational psychiatry. 1: e57 A1 Journal article (refereed), original research

Midlife healthy-diet index and late-life dementia and Alzheimer's disease

Eskelinen Marjo, Ngandu Tiia, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. 2011. Dementia and geriatric cognitive disorders. 1: 103-112 A1 Journal article (refereed), original research

Multi-method analysis of MRI images in early diagnostics of Alzheimer's Disease

Wolz R, Julkunen V, Koikkalainen J, Niskanen E, Zhang DP, Rueckert D, Soininen H, Lötjönen J. 2011. PLoS ONE. 6: e25446 A1 Journal article (refereed), original research

Multi-template tensor-based morphometry: Application to analysis of Alzheimer's disease

Koikkalainen Juha, Lötjönen Jyrki, Thurfjell Lennart, Rueckert Daniel, Waldemar Gunhild, Soininen Hilkka. 2011. Neuroimage. 56: 1134-1144 A1 Journal article (refereed), original research

Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls

Westman Eric, Simmons Andrew, Zhang Yi, Muehlboeck J-Sebastian, Tunnard Catherine, Liu Yawu, Collins Louis, Evans Alan, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Lovestone Simon, Spenger Christian, Wahlund Lars-Olof. 2011. Neuroimage. 54: 1178-1187 A1 Journal article (refereed), original research

New insights into Alzheimer's disease progression: A combined TMS and structural MRI study

Niskanen Eini, Könönen Mervi, Määttä Sara, Hallikainen Merja, Kivipelto Miia, Casarotto Silvia, Massimini Marcello, Vanninen Ritva, Mervaala Esa, Karhu Jari, Soininen Hilkka. 2011. PLoS ONE. 6: e26113 A1 Journal article (refereed), original research

No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease

Turunen Mari, Vepsäläinen Saila, Mäkinen Petra, Helisalmi Seppo, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2011. Neurobiology of aging. 32: 547.e7-547.e9 A1 Journal article (refereed), original research

Plasma biomarkers of brain atrophy in Alzheimer's Disease

Thambisetty M, Simmons A, Hye A, Campbell J, Westman E, Zhang Y, Wahlund L-O, Kinsey A, Causevic M, Killick R, Kloszweska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lovestone S. 2011. PLoS ONE. 6: e28527 A1 Journal article (refereed), original research

Regional differences in effects of APOE allele4 on cognitive impairment in non-demented subjects

Nordberg J, Graff C, Almkvist O, Ewers M, Frisoni GB, Fröhlich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili F, Olde Rikkert M, Rigaud A-S, Scheltens P, Soininen H, Spiru L, Tsolari M, Wahlund L-O, Vellas B, Wilcock G, Elias-Sonnenschein LS, Verhey FRJ, Visser PJ. 2011. Dementia and geriatric cognitive disorders. 32: 135-142 A1 Journal article (refereed), original research

Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's Disease

Westman E, Cavallin L, Muehlboeck J-S, Zhang Y, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Simmons A, Wahlund L-O. 2011. PLoS ONE. 6: e22506 A1 Journal article (refereed), original research

Software tool for improved prediction of Alzheimer's Disease

Soininen H, Mattila J, Koikkalainen J, van Gils M, Hviid Simonsen A, Waldemar G, Rueckert D, Thurfjell L, Lötjönen J. 2011. Neurodegenerative diseases. doi:10.1159/000332600: www.karger.com/ndd A1 Journal article (refereed), original research

Structure and function of medial temporal and posteromedial cortices in early Alzheimer's disease

Miettinen PS, Pihlajamäki M, Jauhiainen AM, Niskanen E, Hänninen T, Vanninen R, Soininen H. 2011. European journal of neuroscience. 34: 320-330 A1 Journal article (refereed), original research

Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol

Boccardi M, Ganzola R, Bocchetta M, Pievani M, Redolfi A, Bartzokis G, Camicioli R, Csernansky JG, de Leon MJ, de Toledo-Morrell L, Killiany RJ, Lehericy S, Pantel J, Pruessner JC, Soininen H, Watson C, Duchesne S, Jack Jr CR, Frisoni GB. 2011. Journal of Alzheimer's disease. 26: 61-75 A2 Review article, Literature review, Systematic review

Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. Negative results

Tolppanen AM, Helisalmi S, Hiltunen M, Kolehmainen M, Schwab U, Pirttilä T, Pulkkinen L, Uusitupa M & Soininen H.. 2011. Neurobiology of aging. 32: 546.e7-546.e9 A1 Journal article (refereed), original research

The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months

Simmons Andrew, Westman Eric, Muehlboeck Sebastian, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Wahlund Lars-Olof, Soininen Hilkka, Lovestone Simon, Evans Alan, Spenger Christian. 2011. International journal of geriatric psychiatry. 26: 75-82 A1 Journal article (refereed), original research

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Mattson N, Andreasson U, Persson S, Arai H, Dev Batish S, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlbors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka S-K. 2011. Alzheimer's & dementia. 7: 386-395 A1 Journal article (refereed), original research

Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

Casarotto S, Määttä S, Herukka SK, Pigorini A, Napolitani M, Gosseries O, Niskanen E, Könönen M, Mervaala E, Rosanova M, Soininen H, Massimini M. 2011. Neuroreport. 22: 592-597 A1 Journal article (refereed), original research

Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland

Bell J Simon, Lönnroos Eija, Koivisto Anne M, Lavikainen Piia, Laitinen Marja-Liisa, Soininen Hilkka, Hartikainen Sirpa. 2011. Journal of Alzheimer's disease. 26: 231-237 A1 Journal article (refereed), original research

Uusia Alzheimerin taudin lääkkeitä etsimässä

Soininen H. 2011. Duodecim. 127: 2345-2347 A1 Journal article (refereed), original research

APOE epsilon-2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes

Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J et al. 2010. Dementia and geriatric cognitive disorders. 30: 229-237 A1 Journal article (refereed), original research

Amyloid and Tau proteins in cortical brain biopsy and Alzheimer's Disease

Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J & Alafuzoff I. 2010. Annals of neurology. 68: 446-453 A1 Journal article (refereed), original research

An association study of 21 potential Alzheimer's disease risk genes in a Finnish population

Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M. 2010. Journal of Alzheimer's disease. 21: 763-767 A1 Journal article (refereed), original research

Analysis of human Tau in cerbrospinal fluid

Hanisch K, Soininen H, Alafuzoff I & Hoffman R. 2010. Journal of proteome research. 9: 1476-1482 A1 Journal article (refereed), original research

Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease

Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M et al. 2010. Neurobiology of aging. 31: 1375-1385 A1 Journal article (refereed), original research

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Guntert A et al. 2010. Archives of general psychiatry. 67: 739-748 A1 Journal article (refereed), original research

Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation

Martikainen P, Pikkarainen M, Pöntynen K, Hiltunen M, Lehtovirta M, Tuisku S, Soininen H & Alafuzoff I. 2010. Neuropathology and applied neurobiology. 36: 41-54 A1 Journal article (refereed), original research

CALHM1 P86L polymorphism does not alter amyloid-beeta or tau in cerebrospinal fluid

Giedraitis V, Glaser A, Sarajärvi T, Brundin RM, Degerman Gunnarsson M, Schjeide BM, Tanzi RE, Helisalmi S et al. 2010. Neuroscience letters. 469: 265-267 A1 Journal article (refereed), original research

CERAD Neuropsychological battery total score in multinational mild cognitive impairment and control populations: The AddNeuroMed Study

Paajanen T, Hänninen T, Tunnard C, Mecocci P, Sobow T, Tsolaki M, Vellas B, Lovestone S & Soininen H. 2010. Journal of Alzheimer's disease. 22: 1089-1097 A1 Journal article (refereed), original research

Cluster analysis and decision trees of MR imaging in patients suffering Alzheimer's

Hamou A, Bauer M, Lewden B, Simmons A, Zhang Y, Wahlund LO, Tunnard C, Kloszewska I, Mecozzi, Soininen H et al. 2010. Trends in Practical Applications of Agents and Multiagent Systems. 71. Springer-Verlag C1 Book

Consensus statement on dementia education and training in Europe

Tsolaki M, Papaliagkas V, Anogianakis G, Bernabei R, Emre M, Frolich L, Visser PJ, Michel JP, Pirttilä T, Olde Rikkert M, Soininen H et al. 2010. Journal of nutrition health and aging. 14: 131-135 A1 Journal article (refereed), original research

Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's Diseaes patients: A longitudinal study

Julkunen V, Niskanen E, Koikkalainen J, Herukka SK, Pihlajamäki M, Hallikainen H, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R & Soininen H. 2010. Journal of Alzheimer's disease. 21: 1141-1151 A1 Journal article (refereed), original research

Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's Disease

Bronzova J, Sampaio C, Hauser RA, Lang AE, Rascol O, Theeuwes A, van de Witte SV, van Scharrenburg G on behalf of the Bruegel Study Group. 2010. Movement disorders. 25: 738-746 A1 Journal article (refereed), original research

Effect of APOE epsilon4 allele on cortical thicknesses and volumes: The AddNeuroMed Study

Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J et al. 2010. Journal of Alzheimer's disease. 21: 947-966 A1 Journal article (refereed), original research

Effects of cholinesterase inhibitors on the activities and protein levels of cholinesterases in the cerebrospinal fluid of patients with Alzheimer's disease: A review of recent clinical studies

Darreh-Shori T & Soininen H. 2010. Current alzheimer research. 7: 67-73 A1 Journal article (refereed), original research

Fast and bobust multi-atlas segmentation of brain magnetic resonance images

Lötjönen JMP, Wolz R, Koikkalainen JR, Thurfjell L, Waldemar G, Soininen H & Rueckert D. 2010. Neuroimage. 49: 2352-2365 A1 Journal article (refereed), original research

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I et al. 2010. Molecular psychiatry. doi:10.1038/mp.2010.123: 1-9 A1 Journal article (refereed), original research

Homocysteine and holotranscobalamin and the risk of Alzheimer disease

Hooshmand B, Solomon A, Kåreholt I, Leivistä J, Rusanen M, Ahtiluoto S, Winblad B, Laatikainen T, Soininen H & Kivipelto M. 2010. Neurology. 75: 1408-1414 A1 Journal article (refereed), original research

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Progress in neurobiology. 93: 99-110 A1 Journal article (refereed), original research

Insight, cognition and quality of life in Alzheimer's disease

Hurt CS, Banerjee S, Tunnard C, Whitehead DL, Tsolaki M, Mecocci P, Kloszewska I & Soininen H et al. 2010. Journal of neurology neurosurgery and psychiatry. 81: 331-336 A1 Journal article (refereed), original research

Lipid-Lowering Treatment Is Related to Decreased Risk of Dementia: A Population-Based Study (FINRISK)

Solomon A, Sippola R, Soininen H, Wolozin B, Tuomilehto J, Laatikainen T & Kivipelto M. 2010. Neurodegenerative diseases. 7: 180-182 A1 Journal article (refereed), original research

Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: A population-based cardiovascular risk factors, aging and dementia study

Rusanen M, Rovio S, Ngandu T, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. 2010. Dementia and geriatric cognitive disorders. 30: 277-284 A1 Journal article (refereed), original research

Muistisairaudet

Erkinjuntti T, Rinne J & Soininen H. 2010. . . WS Bookwell Oy C1 Book

Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease

Karttunen K, Karppi P, Hiltunen A, Vanhanen M, Välimäki T, Martikainen J, Valtonen H, Sivenius J, Soininen H, Hartikainen S, Suhonen J & Pirttilä T; for the ALSOVA study group. 2010. International journal of geriatric psychiatry. 2011:26: 473-482 A1 Journal article (refereed), original research

Plasma A-beta42 and A-beta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study

Seppälä TT, Herukka SK, Hänninen T, Tervo S, Hallikainen M, Soininen H & Pirttilä T. 2010. Journal of neurology neurosurgery and psychiatry. 81: 1123-1127 A1 Journal article (refereed), original research

Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease

Oresic M, Lötjönen J & Soininen H. 2010. Genome medicine. 2: 2-5 B1 Non-refereed journal articles

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

Lambert JC, Sleegers K, Gonzalez-Perez A, Ingelsson M, Beecham GW, Hiltunen M et al. 2010. Journal of Alzheimer's disease. 22: 247-255 A1 Journal article (refereed), original research

The effect of midlife physical activity on structural brain changes in the elderly

Rovio S, Spulber G, Nieminen LJ, Niskanen E, Winblad B, Tuomilehto J, Nissinen A, Soininen H & Kivipelto M. 2010. Neurobiology of aging. 31: 1927-1936 A1 Journal article (refereed), original research

Whole brain atrophy rate predicts progression from MCI to Alzheimer's disease

Spulber G, Niskanen E, MacDonald S, Smilovici O, Chen K, Reiman EM, Jauhiainen AM, Hallikainen M, Tervo S, Wahlund LO, Vanninen R, Kivipelto M, Soininen H. 2010. Neurobiology of aging. 31: 1601-1605 A1 Journal article (refereed), original research

cNEUPRO: Novel biomarkers for neurodegenerative diseases

Spitzer P, Klafki HW, Blennow K, Buee L, Esselmann H, Herukka SK, Jimenez C, Klivenyi P, Lewczuk P, Maler JM et al. 2010. International journal of alzheimers disease. ID548145: 1-12 A2 Review article, Literature review, Systematic review

AddNeuroMed - The European collaboration for the discovery of novel biomarkers for Alzheimer's disease

Lovestone S, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund L-O, Ward M, on behalf of the AddNeuroMed Consortium, Soininen H. 2009. Annals of the New York Academy of Sciences. 1180: 36-46 A1 Journal article (refereed), original research

An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population

Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M, Soininen H, Hiltunen M, Helisalmi S. 2009. American journal of medical genetics. Part B : neuropsychiatric genetics. 150B: 747-750 A1 Journal article (refereed), original research

Association between mid-life marital status and cognitive function in later life: population based cohort study

Håkansson K, Rovio S, Helkala E-L, Vilska A-R, Windlad B, Soininen H, Nissinen A, Mohammed AH, Kivipelto M, Soininen H. 2009. BMJ. 339: A1 Journal article (refereed), original research

Beta-amyloid deposition in brains of subjects with diabetes

Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H, Soininen H. 2009. Neuropathology and applied neurobiology. 1: 60-68 A1 Journal article (refereed), original research

Cerebrospinal fluid {beta}-amyloid 42 and Tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain

Tapiola T, Alafuzoff I, Herukka S-K, Parkkinen L, Hartikainen P, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2009. Archives of neurology. 66: 382-389 A1 Journal article (refereed), original research

Combined risk effects of IDE and NEP gene variants on Alzheimer disease

Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M, Helisalmi S, Pirttilä T, Soininen H, Hiltunen M. 2009. Journal of neurology neurosurgery and psychiatry. 80: 1268-1270 A1 Journal article (refereed), original research

Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease

Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, Hallikainen M, Kivipelto M, Tervo S, Vanninen R, Evans A, Soininen H, Soininen H. 2009. Dementia and geriatric cognitive disorders. 28: 404-412 A1 Journal article (refereed), original research

Different cholinesterase inhibitor effects on CSF cholines Alzheimer patients

Nordberg A, Darreh-Shori T, Peskind E, Soininen H, Mousavi M, Eagle G, Lane R, Soininen H. 2009. Current alzheimer research. 6: 4-14 A1 Journal article (refereed), original research

Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment

Jauhiainen AM, Pihlajamäki M, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H, Soininen H. 2009. Hippocampus. 19: 166-175 A1 Journal article (refereed), original research

Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis

Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M, Soininen H, Hiltunen M. 2009. Journal of biological chemistry. 284: 34433-34443 A1 Journal article (refereed), original research

Effects of ubiquillin 1 on the unfolded protein response

Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE, Hiltunen M, Soininen H. 2009. Journal of molecular neuroscience. 38: 19-30 A1 Journal article (refereed), original research

Flanking markers of cyntation C (CST3) gene do not show association with Alzheimer's disease

Helisalmi S, Väkevä A, Hiltunen M, Soininen H, Soininen H, Helisalmi S. 2009. Dementia and geriatric cognitive disorders. 27: 318-321 A1 Journal article (refereed), original research

Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus

Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J, Hiltunen M, Sivenius J, Soininen H. 2009. Neurobiology of disease. 35: 103-113 A1 Journal article (refereed), original research

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Lambert JC, Heath S, Even G..., Hiltunen M, Combarros O..., Helisalmi S, Porcellini E..., Licastro F, Soininen H, Ritchie K..., Amouyel P, Hiltunen M, Helisalmi S, Soininen H. 2009. Nature genetics. 41: 1047-1048 A1 Journal article (refereed), original research

Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease

Singer D, Soininen H, Alafuzoff I, Hoffmann R, Soininen H. 2009. . 395: 2263-2267 A1 Journal article (refereed), original research

MRI measures of Alzheimer's disease and the AddNeuroMed study

Simmons A, Westman E, Muehlboeck S, Meccoci P, Vellas B, Tsolaki M, Kloszewska I, Wahlund L-O, Soininen H, Lovestone S, Evans A, Spenger C, for the AddNeuroMed Consortium, Soininen H. 2009. Annals of the New York Academy of Sciences. 1180: 47-55 A1 Journal article (refereed), original research

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study

Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M, Soininen H. 2009. Journal of Alzheimer's disease. 16: 85-91 A1 Journal article (refereed), original research

Muistihäiriöpotilaan neurologisten löydösten diagnostiset vihjeet

Soininen H, Soininen H. 2009. Lääkärilehti. 64: 4049-4053 A2 Review article, Literature review, Systematic review

Olfactory identification in non-demented elderly population and mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test

Laakso MP, Tervo S, Hänninen T, Vanhanen M, Hallikainen M, Soininen H, Soininen H, Laakso MP. 2009. Journal of neural transmission. 116: 891-895 A1 Journal article (refereed), original research

Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease

Solomon A, Leoni V, Kivipelto M, Besga A, Öksengård AR, Julin P, Svensson L, Wahlund L-O, Andreasen N, Winbland B, Soininen H, Björkhem I, Soininen H. 2009. Neuroscience letters. : 89-93 A1 Journal article (refereed), original research

Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study

Visser PJ, Verhey F, Knol DL, Scheltens P, Wahlund L-O, Freud-Levi Y, Tsolaki M, Minthon L, Wallin ÅK, Hampel H, Burger K, Pirttila T, Soininen H, Rikkert MO, Verbeek MM, Spiru L, Blennow K, Pirttilä T, Soininen H. 2009. The Lancet Neurology. 8: 619-627 A1 Journal article (refereed), original research

Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment

Ferris S, Nordberg A, Soininen H, Darreh-Shori T, Lane R, Soininen H. 2009. Pharmacogenetics and genomics. : 635-646 A1 Journal article (refereed), original research

Safety of lumbar puncture procedures in patients with Alzheimer's disease

Peskind E, Nordberg A, Darreh-Shori T, Soininen H, Soininen H. 2009. Current alzheimer research. 6: 290-292 A1 Journal article (refereed), original research

Serum total cholesterol, statins and cognition in non-demented elderly

Solomon A, Kåreholt I, Ngandu T, Wolozin B, Macdonald SW, Winbland B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M, Soininen H. 2009. Neurobiology of aging. 30: 1006-1009 A1 Journal article (refereed), original research

Structural and functional MRI in mild cognitive impairment

Pihlajamäki M, Jauhiainen AM, Soininen H, Soininen H. 2009. Current alzheimer research. 6: 179-185 A1 Journal article (refereed), original research

White matter hyperintensities and medial temporal lobe atrophy in clincal subtypes of mild cognitive impairment: the DESCRIPA study

van de Pol LA, Verhey F, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund L-O, Minthon L, Frölich L, Hampel H, Soininen H, Knol DL, Barkhof F, Scheltens P, Visser PJ, Soininen H. 2009. Journal of neurology neurosurgery and psychiatry. 80: 1069-1074 A1 Journal article (refereed), original research

A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease

Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. Biochemical and biophysical research communications. 375: 356-361 A1 Journal article (refereed), original research

Apolipoprotein E epsilon4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study

Hämäläinen A, Grau-Olivares M, Tervo S, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala E-L, Nissinen A, Vanninen RL, Soininen H, Hallikainen M, Soininen H. 2008. Neurodegenerative diseases. 5: 186-189 A1 Journal article (refereed), original research

Apolipoprotein E epsilon4 magnifiles lifestyle risks for dementia: a population-based study

Kivipelto M, Rovio S, Ngandu T, Kåreholt I, Eskelinen M, Wiblad B, Hachinski V, Cedazo-Minguez A, Soininen H, Tuomilehto J, Nissinen A, Soininen H. 2008. Journal of cellular and molecular medicine. 12: 2762-2771 A1 Journal article (refereed), original research

Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11- labeled Pittsburgh compound B

Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne J, Pirttilä T, Soininen H. 2008. Archives of neurology. 65: 1304-1309 A1 Journal article (refereed), original research

Brain anatomy of persistent violent offenders: more rather than less

Tiihonen J, Rossi R, Laakso MP, Hodgins S, Testa C, Perez J, Repo-Tiihonen E, Vaurio O, Soininen H, Aronen HJ, Könönen M, Thompson PM, Frisoni G, Könönen M, Soininen H. 2008. Psychiatry research: neuroimaging. 163: 201-212 A1 Journal article (refereed), original research

CSF Abeeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy

Herukka S-K, Pennanen C, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2008. Journal of Alzheimer's disease. 14: 51-57 A1 Journal article (refereed), original research

Coaccumulation of calcium and b-amyloid in the thalamus after transient middle cerebral artery occlusion in rats

Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J, Hiltunen M, Soininen H. 2008. Journal of cerebral blood flow and metabolism. 28: 263-268 A1 Journal article (refereed), original research

Dementoivat sairaudet ja kognitiivinen prosessointi

Soininen H, Hänninen T, Soininen H. Teoksessa: Juntunen J et al(toim.) , 2008. Aivot ja ajattelu. Kliininen kognitiivinen neurotiede. s. 102-118. Recallmed A3 Book section, Chapters in research books

Development of screening guidelines and clinical criteria for predementia Alzheimer's disease

Visser PJ, Verhey FRJ, Boada M, Bullock R, De Deyn PP, Frisoni GB, Frölich L, Hampel H, Jolles J, Jones R, Minthon L, Nobili F, Olde Rikkert M, Ousset P-J, Rigaud A-S, Scheltens P, Soininen H, Spiru L ..., Soininen H, DESCRIPA Study Group. 2008. Neuroepidemiology. 30: 254-265 A1 Journal article (refereed), original research

Differential hypometabolism patterns according to mild cognitive impairment subtypes

Jauhiainen AM, Kangasmaa T, Rusanen M, Niskanen E, Tervo S, Kivipelto M, Vanninen RL, Kuikka JT, Soininen H, Soininen H. 2008. Dementia and geriatric cognitive disorders. 26: 490-498 A1 Journal article (refereed), original research

Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study

Eskelinen MH, Ngandu T, Helkala EL, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M, Soininen H. 2008. International journal of geriatric psychiatry. 23: 741-747 A1 Journal article (refereed), original research

Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Journal of neurology. 255: 668-673 A1 Journal article (refereed), original research

Genetic study evaluating LDLR polymorphisms and Alzheimer's disease

Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Pirttilä T, Soininen H. 2008. Neurobiology of aging. 29: 848-855 A1 Journal article (refereed), original research

Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology

Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Neuroscience letters. 438: 216-220 A1 Journal article (refereed), original research

Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease

Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H, Helisalmi S, Hiltunen M, Soininen H. 2008. Neuroscience letters. 441: 233-236 A1 Journal article (refereed), original research

Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease

Blom ES, Viswanathan J, Kilander L, Helisalmi S, Soininen H, Lannfelt L, Ingelsson M, Glaser A, Hiltunen M, Helisalmi S, Soininen H, Hiltunen M. 2008. European journal of human genetics. 16: 171-175 A1 Journal article (refereed), original research

MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study

Tapiola T, Pennanen C, Tapiola M, Tervo S, Kivipelto M, Hänninen T, Pihlajamäki M, Laakso MP, Hallikainen M, Hämäläinen A, Vanhanen M, Helkala EL, Vanninen R, Nissinen A, Rossi R, Frisoni GB, Soininen H. 2008. Neurobiology of aging. 29: 31-38 A1 Journal article (refereed), original research

Mixed brain pathologies in dementia: the BrainNet Europe consortium experience

Kovacs GG, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Capellari S, Ferrer I, Gelpi E, Kövari V, Kretzschmar H, Nagy Z, Parchi P, Seilhean D, Soininen H, Troakes C, Budka H, Soininen H. 2008. Dementia and geriatric cognitive disorders. 26: 343-350 A1 Journal article (refereed), original research

Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: a pilot study

Julkunen P, Jauhiainen AM, Westerén-Punnonen S, Pirinen E, Soininen H, Könönen M, Pääkkönen A, Määttä S, Karhu J, Könönen M, Soininen H. 2008. Journal of neuroscience methods. 172: 270-276 A1 Journal article (refereed), original research

No association between CALHM1 and Alzheimers's disease risk

Bertram L, Schjeide BMM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE, Hiltunen M, Soininen H. 2008. Cell

PET amyloid ligand (11C)PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment

Koivunen J, Pirttilä T, Kemppainen N, Aalto S, Herukka S-K, Jauhiainen AM, Hänninen T, Hallikainen M, Någren K, Rinne JO, Soininen H, Pirttilä T, Soininen H. 2008. Dementia and geriatric cognitive disorders. 26: 378-383 A1 Journal article (refereed), original research

Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease

Lane R, Feldman HH, Meyer J, He Y, Ferris SH, Nordberg A, Darreh-Shori T, Soininen H, Pirttilä T, Farlow MR, Sfikas N, Ballard C, Greig NG, Soininen H, Pirttilä T. 2008. Pharmacogenetics and genomics. 18: 289-298 A1 Journal article (refereed), original research

Alcohol drinking and cognitive functions: findings from the cardiovascular risk factors aging and dementia (CAIDE) study

Ngandu T, Helkala E-L, Soininen H, Winblad B, Tuomilehto J, Nissinen A, Kivipelto M. 2007. Dementia and geriatric cognitive disorders. 23: 140-149 A1 Journal article (refereed), original research

CSF Abeta42, tau and phosphorylated tau, APOE epsilon4 allele and MCI type in progressive MCI

Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T, Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T. 2007. Neurobiology of aging. 28: 507-514 A1 Journal article (refereed), original research

Education and dementia: What lies behind the association?

Ngandu T, von Strauss E, Helkala E-L, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M, Soininen H. 2007. Neurology. 69: 1442-1450 A1 Journal article (refereed), original research

Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy

Sakka P, Tsolaki M, Hort J, Hager K, Soininen H, Pousa SL, Li C, Schwam E, Soininen H. 2007. Current medical research and opinion. 23: 3153-3165 A1 Journal article (refereed), original research

Increased fMRI responses during encoding in mild cognitive impairment

Hämäläinen A, Pihlajamäki M, Tanila H, Hänninen T, Niskanen E, Tervo S, Karjalainen PA, Vanninen RL, Soininen H, Soininen H, Tervo S. 2007. Neurobiology of aging. 28: 1889-1903 A1 Journal article (refereed), original research

Insulin-degrading enzyme is genetically associated wirh Alzheimer's disease in the finnish population

Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M, Vepsäläinen S, Helisalmi S, Soininen H, Hiltunen M. 2007. Journal of medical genetics. 44: 606-608 A1 Journal article (refereed), original research

Long-term efficacy and safety of celecoxib in Alzheimer¿s disease

Soininen H, West C, Robbins J, Niculescu L, Soininen H. 2007. Dementia and geriatric cognitive disorders. 23: 8-21 A1 Journal article (refereed), original research

Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats

Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J, Soininen H. 2007. European journal of neuroscience. 26: 1845-1852 A1 Journal article (refereed), original research

Serum cholesterol changes after midlife and late-life cognition. Twenty-one-year follow-up study

Solomon A, Kåreholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. 2007. Neurology. 68: 751-756 A1 Journal article (refereed), original research

Somatostatin genetic variants modify the risk for Alzheimer¿s disease among finnish patients

Vepsäläinen S, Helisalmi S, Koivisto AM, Tapaninen T, Hiltunen M, Soininen H, Vepsäläinen S, Helisalmi S, Hiltunen M, Soininen H. 2007. Journal of neurology. 254: 1504-1508 A1 Journal article (refereed), original research

Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers

Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H. 2007. Dementia and geriatric cognitive disorders. 24: 146-150 A1 Journal article (refereed), original research

Subspace approaches for fMRI time series estimation

Niskanen EI, Tarvainen MP, Könönen M, Soininen H, Karjalainen PA, Könönen M. Teoksessa: (toim.) , 2007. Proceedings of the 29th Annual International Conference of the IEEE EMBS. s. 5485-5488. IOP Publishing A4 Conference proceedings

The association study between DHCR24 polymorphisms and Alzheimer's disease

Lämsä R, Helisalmi S, Hiltunen M, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S. 2007. American journal of medical genetics. Part B : neuropsychiatric genetics. 144B: 906-910 A1 Journal article (refereed), original research

Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study

Joyal CC, Putkonen A, Mancini-Marïe A, Hodgins S, Kononen M, Boulay L, Pihlajamaki M, Soininen H, Stip E, Tiihonen J, Aronen HJ, Könönen M. 2007. Schizophrenia research. 91: 97-102 A1 Journal article (refereed), original research

Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment

Hämäläinen A, Tervo S, Grau-Olivares M, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala E-L, Nissinen A, Vanninen R, Soininen H, Hämäläinen A, Tervo S, Vanhanen M, Hallikainen M, Soininen H. 2007. Neuroimage. 37: 1122-1131 A1 Journal article (refereed), original research

Work-related physical activity and the risk of dementia and Alzheimer's disease

Rovio S, Kåreholt I, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M, Soininen H. 2007. International journal of geriatric psychiatry. 22: 874-882 A1 Journal article (refereed), original research

3-Year study of Donepezil therapy in Alzheimer¿s Disease: Effects of early and continuous therapy

Winblad B, Wimo A, Engedal K, Soininen H, Verhey F, Waldemar G, Wetterholm A-L, Haglund A, Zhang R, Schindler R, For the Donepezil Nordic Group, Soininen H. 2006. Dementia and geriatric cognitive disorders. 21: 353-363 A1 Journal article (refereed), original research

Aromatase enzyme and Alzheimer¿s disease

Hiltunen M, Iivonen S, Soininen H, Hiltunen M, Soininen H. 2006. Minerva endocrinologica. 31: 61-73 A1 Journal article (refereed), original research

Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

Zhou X-W, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei J-J. 2006. Neurobiology of disease. 22: 657-668 A1 Journal article (refereed), original research

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453 A1 Journal article (refereed), original research

Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary

Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Journal of neurology neurosurgery and psychiatry. 77: 421-422 A1 Journal article (refereed), original research

Association of metabolic syndrome with Alzheimer disease: a population-based study

Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. 2006. Neurology. 67: 843-847 A1 Journal article (refereed), original research

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

Buerger K, Ewers M, Pirttilä T, Zinkowski R, Alafuzoff I, Teipel SJ, DeBernardis J, Kerkman D, McCulloch C, Soininen H, Hampel H, Pirttilä T, Soininen H. 2006. Brain. 129: 3035-3041 A1 Journal article (refereed), original research

Cerebrospinal fluid Abeta42, tau and phosphorylated tau predict progression in patients with cognitive impairment

Herukka S-K, Hallikainen M, Tervo S, Helisalmi S, Tapiola T, Soininen H, Pirttilä T, Hallikainen M, Tervo S, Helisalmi S, Soininen H, Pirttilä T. Teoksessa: Vellas B, Winblad B, Grundman M, Fitten LJ, Feldman H, Giacobini E, Kurz A(toim.) , 2006. Research and Practice in Alzheimer¿s Disease. s. 245-250. Serdi A3 Book section, Chapters in research books

Determinants of costs of care for patients with Alzheimer¿s disease

Jönsson L, Jönhagen ME, Kilander L, Soininen H, Hallikainen M, Waldemar G, Nygaard H, Andreasen N, Winblad B, Wimo A, Soininen H, Hallikainen M. 2006. International journal of geriatric psychiatry. 21: 449-459 A1 Journal article (refereed), original research

Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice

Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Neuroscience. 137: 1143-1152 A1 Journal article (refereed), original research

Fat intake at midlife and risk of dementia and Alzheimer¿s disease: A population-based study

Laitinen MH, Ngandu T, Rovio S, Helkala E-L, Uusitalo U, Viitanen M, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. 2006. Dementia and geriatric cognitive disorders. 22: 99-107 A1 Journal article (refereed), original research

Kliinis-neurofysiologiset tutkimukset

Soininen H, Partanen J. Teoksessa: Erkinjuntti T, Alhainen K, Rinne J, Soininen H(toim.) , 2006. Muistihäiriöt ja dementia. 2. uud. p.. s. 431-437. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Mikä on näyttö yli 80-vuotiaiden dementian hoidosta

Soininen H. 2006. Lääkärilehti. 61: 4215-4217 A2 Review article, Literature review, Systematic review

Muistihäiriöiden ja dementian ennaltaehkäisy

Soininen H. Teoksessa: Erkinjuntti T, Alhainen K, Rinne J, Soininen H(toim.) , 2006. Muistihäiriöt ja dementia. 2. uud. p.. s. 464-471. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Muistihäiriöiden oirediagnostiikka

Soininen H, Hänninen T. Teoksessa: Erkinjuntti T, Alhainen K, Rinne J, Soininen H(toim.) , 2006. Muistihäiriöt ja dementia. 2. uud. p.. s. 82-92. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Muistihäiriöt ja dementia. 2. uud. p

Erkinjuntti T, Alhainen K, Rinne J, Soininen H. 2006. . . Duodecim D6 Edited professional book

Patient- and proxy-reported utility in Alzheimer disease using the euroQoL

Jönsson L, Andreasen N, Kilander L, Soininen H, Waldemar G, Nygaard H, Winblad B, Jönhagen ME, Hallikainen M, Wimo A, Soininen H, Hallikainen M. 2006. Alzheimer disease and associated disorders. 20: 49-55 A1 Journal article (refereed), original research

Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study

Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. 2006. The Lancet Neurology. 5: 735-741 A1 Journal article (refereed), original research

The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: A voxel-based morphometric study

Pennanen C, Testa C, Boccardi M, Laakso MP, Hallikainen M, Helkala E-L, Hänninen T, Kivipelto M, Könönen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H, Könönen M, Hallikainen M, Tervo S, Soininen H, Laakso MP. 2006. Dementia and geriatric cognitive disorders. 22: 60-66 A1 Journal article (refereed), original research

A voxel based morphometry study on mild cognitive impairment

Pennanen C, Testa C, Laakso MP, Hallikainen M, Helkala E-L, Hänninen T, Kivipelto M, Könönen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H, Laakso MP, Könönen M, Soininen H. 2005. Journal of neurology neurosurgery and psychiatry. 76: 11-14 A1 Journal article (refereed), original research

CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment

Herukka S-K, Hallikainen M, Soininen H, Pirttilä T, Hallikainen M, Soininen H, Pirttilä T. 2005. Neurology. 64: 1294-1297 A1 Journal article (refereed), original research

Can mild cognitive impairment predict Alzheimer¿s disease?

Soininen H, Tuomainen S, Pennanen C, Hänninen T, Kivipelto M, Soininen H. Teoksessa: Hanin I, Cacabelos R, Fisher A(toim.) , 2005. Recent Progress in Alzheimer¿s and Parkinson¿s Disease. s. 191-195. Taylor & Francis A3 Book section, Chapters in research books

Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects

Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Aronen HJ, Soininen H, Soininen H, könönen m. 2005. European journal of neuroscience. 22: 2095-2105 A1 Journal article (refereed), original research

Estrogen receptor beta gene variants are associated with increased risk of Alzheimer¿s disease in women

Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2005. European journal of human genetics. 13: 1000-1006 A1 Journal article (refereed), original research

Frontotemporal dementia as a neural system disease

Boccardi M, Sabbatoli F, Laakso MP, Testa C, Rossi R, Beltramello A, Soininen H, Frisoni GB, Laakso MP, Soininen H. 2005. Neurobiology of aging. 26: 37-44 A1 Journal article (refereed), original research

Genetic analysis on BDNF and TrkB gene polymorphisms in Alzheimer's disease

Vepsäläinen S, Castren E, Helisalmi S, Iivonen S, Mannermaa A, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Vepsäläinen S, Helisalmi S, Iivonen S, Soininen H, Hiltunen M. 2005. Journal of neurology. 252: 423-428 A1 Journal article (refereed), original research

Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease

Rovio S, Kåreholt I, Helkala E-L, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. 2005. The Lancet Neurology. 4: 705-711 A1 Journal article (refereed), original research

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alxheimer's disease brain

Li X, Alafuzoff I, Soininen H, Winblad B, Pei J-J, Soininen H. 2005. Febs journal. 272: 4211-4220 A1 Journal article (refereed), original research

Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods

Chaudhuri JD, Hiltunen M, Nykänen M, Ylä-Herttuala S, Soininen H, Miettinen R, Hiltunen M, Soininen H. 2005. Neuroscience. 131: 557-566 A1 Journal article (refereed), original research

Muistihäiriöiden varhaisdiagnostiikka kaipaa tehostamista

Soininen H, Soininen H. 2005. Lääkärilehti

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer¿s disease

Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, Helkala E-L, Tuomilehto J, Soininen H, Nissinen A, Soininen H. 2005. Archives of neurology. 62: 1556-1560 A1 Journal article (refereed), original research

Onko Alzheimer-lääkkeistä hyötyä?

Soininen H, Pirttilä T, Soininen H. 2005. Duodecim

Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy

Miettinen R, Riedel A, Kalesnykas G, Kettunen H-P, Puoliväli J, Soininen H, Arendt T, Soininen H. 2005. Journal of chemical neuroanatomy. 30: 105-118 A1 Journal article (refereed), original research

Response to letter by Bullock and Truyen

Jones R, Soininen H, Hager K, Aarsland D, Passmore P, Soininen H. 2005. International journal of geriatric psychiatry

Structural correlates of early and late onset Alzheimer`s disease: voxel based morphometric study

Frisconi GB, Testa C, Sabattoli F, Beltramello A, Soininen H, Laakso MP, Laakso MP, Soininen H. 2005. Journal of neurology neurosurgery and psychiatry. 76: 112-114 A1 Journal article (refereed), original research

Subgroups of Alzheimer¿s disease based on cerebrospinal fluid molecular markers

Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I, Soininen H, Pirttilä T. 2005. Annals of neurology. 58: 748-757 A1 Journal article (refereed), original research

Visual assessment of medial temporal atrophy on MR films in Alzheimer¿s disease: comparison with volumetry

Bresciani L, Rossi R, Testa C, Geroldi C, Galluzzi S, Laakso MP, Beltramello A, Soininen H, Frisoni GB, Laakso MP, Soininen H. 2005. Aging clinical and experimental research. 17: 8-13 A1 Journal article (refereed), original research

A comparison between the accurancy of voxel-based morphometry and hippocampal volumetry in Alzheimer`s disease

Testa C, Laakso MP, Sabattoli F, Rossi R, Beltramello A, Soininen H, Frisoni GB, Laakso MP, Soininen H. 2004. Journal of magnetic resonance imaging. 19: 274-282 A1 Journal article (refereed), original research

A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer¿s disease

Jones RW, Soininen H, Hager K, Aarsland D, Passmore P, The DONGAL Study Group, Murthy A, Zhang R, Bahra R, Soininen H. 2004. International journal of geriatric psychiatry. 19: 58-67 A1 Journal article (refereed), original research

APOE and modulation of Alzheimer¿s and frontotemporal dementia

Boccardi M, Sabattoli F, Testa C, Beltramello A, Soininen H, Frisoni GB, Soininen H. 2004. Neuroscience letters. 356: 167-170 A1 Journal article (refereed), original research

Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study

Anttila T, Helkala E-L, Viitanen M, Kåreholt I, Fratiglioni L, Winblad B, Soininen H, Tuomilehto J, Nissinen A, Kivipelto M, Soininen H. 2004. BMJ international edition. 329: 539-544 A1 Journal article (refereed), original research

Alzheimerin taudin genetiikka

Hiltunen M, Helisalmi S, Kivipelto M, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2004. Duodecim. 120: 2425-2431 A2 Review article, Literature review, Systematic review

Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2004. Neuroscience letters. 368: 181-185 A1 Journal article (refereed), original research

Genetic variation in apolipoprotein D and Alzheimer¿s disease

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder EH, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Koivisto AM, Soininen H. 2004. Journal of neurology. 251: 951-957 A1 Journal article (refereed), original research

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala E-L, Vainio P, Vanninen R, Partanen K, Soininen H, Pennanen C, Kivipelto M, Tuomainen S, Hänninen T, Hallikainen M, Vanhanen M. 2004. Neurobiology of aging. 25: 303-310 A1 Journal article (refereed), original research

Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects

Tervo S, Kivipelto M, Hänninen T, Vanhanen M, Hallikainen M, Mannermaa A, Soininen H, Tervo S, Kivipelto M, Hänninen T, Vanhanen M, Hallikainen M, Soininen H. 2004. Dementia and geriatric cognitive disorders. 17: 196-203 A1 Journal article (refereed), original research

Mitochondrial DNA polymorphisms as risk factors for Parkinson¿s disease and Parkinson¿s disease dementia

Autere J, Moilanen JS, Finnilä S, Soininen H, Mannermaa A, Hartikainen P, Hallikainen M, Majamaa K, Soininen H. 2004. Human genetics. 115: 29-35 A1 Journal article (refereed), original research

Muistihäiriöt ja dementia

Hänninen T, Soininen H, Soininen H. Teoksessa: Raitanen T, Hänninen T, Pajunen H, Suutama T(toim.) , 2004. Geropsykologia - vanhenemisen ja vanhuuden psykologia. s. 182-192. WSOY D2 Article in a professional book (incl. an introduction by the editor)

Phosphorylated eukaryotic translation factor 4E is elevated in alzheimer brain

Li X, An W-L, Alafuzoff I, Soininen H, Winblad B, Pei J-J, Soininen H. 2004. Neuroreport. 15: 2237-2240 A1 Journal article (refereed), original research

Polymorphisms in neprilysin gene affect the risk of Alzheimer¿s disease in Finnish patients

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto AM, Alafuzoff I, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Koivisto AM, Soininen H, Iivonen S. 2004. Journal of neurology neurosurgery and psychiatry. 75: 1746-1748 A1 Journal article (refereed), original research

Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease

Iivonen S, Corder E, Lehtovirta M, Helisalmi S, Mannermaa A, Vepsäläinen S, Hänninen T, Soininen H, Hiltunen M, Iivonen S, Hiltunen M, Soininen H, Helisalmi S, Vepsäläinen S. 2004. Neurology. 62: 1170-1176 A1 Journal article (refereed), original research

Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population

Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto AM, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C, Soininen H. 2004. Neurology. 63: 173-175 A1 Journal article (refereed), original research

Serum testosterone levels in males with Alzheimer¿s disease

Pennanen C, Laakso MP, Kivipelto M, Ramberg J, Soininen H, Laakso MP, Soininen H. 2004. Journal of neuroendocrinology. 16: 95-98 A1 Journal article (refereed), original research

Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans

Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Hämäläinen A, Soininen H, Aronen HJ, Könönen M, Soininen H. 2004. European journal of neuroscience. 19: 1939-1949 A1 Journal article (refereed), original research

Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer¿s disease in Finnish patients

Mattila KM, Hiltunen M, Rinne JO, Mannermaa A, Röyttä M, Alafuzoff I, Laippala P, Soininen H, Lehtimäki T. 2003. Neuroscience letters. 337: 61-63 A1 Journal article (refereed), original research

An economic evaluation of donepezil in mild to moderate Alzheimer¿s disease: Results of a 1-year, double-blind, randomized trial

Wimo A, Winblad B, Engedal K, Soininen H, Verhey F, Waldemar G, Wetterholm A-L, Mastey V, Haglund A, Zhang R, Miceli R, Chin W, Subbiah P, Donepezil Nordi Study Group, Hallikainen M, Jäkälä P, Riekkinen M. 2003. Dementia and geriatric cognitive disorders. 15: 44-54 A1 Journal article (refereed), original research

Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers

Laakso MP, Hiltunen Y, Könönen M, Kivipelto M, Koivisto A, Hallikainen M, Soininen H, Laakso MP. 2003. Journal of neural transmission. 110: 267-275 A1 Journal article (refereed), original research

Encoding of novel picture pairs activates the perirhinal cortex: An fMRI study

Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Mikkonen M, Jalkanen V, Partanen K, Aronen HJ, Soininen H. 2003. Hippocampus. 13: 67-80 A1 Journal article (refereed), original research

Heparan sulfate proteoglycan 2 polymorphism in Alzheimer¿s disease and correlation with neuropathology

Iivonen S, Helisalmi S, Mannermaa A, Alafuzoff I, Lehtovirta M, Soininen H, Hiltunen M. 2003. Neuroscience letters. 352: 146-150 A1 Journal article (refereed), original research

Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC

Frisoni GB, Scheltens P, Galluzzi S, Nobili FM, Fox NC, Robert PH, Soininen H, Wahlund L-O, Waldemar G, Salmon E. 2003. Journal of neurology neurosurgery and psychiatry. 74: 1371-1381 A2 Review article, Literature review, Systematic review

Reelin-immunoreactive cajal-retzius cells: the entorhinal cortex in normal aging and alzheimer¿s disease

Riedel A, Miettinen R, Stieler J, Mikkonen M, Alafuzoff I, Soininen H, Arendt T. 2003. Acta neuropathologica. 106: 291-302 A1 Journal article (refereed), original research

Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease

Parkkinen L, Soininen H, Alafuzoff I. 2003. Journal of neuropathology and experimental neurology. 62: 363-367 A1 Journal article (refereed), original research

The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia

Boccardi M, Laakso MP, Bresciani L, Galluzzi S, Geroldi C, Beltramello A, Soininen H, Frisoni GB, Laakso MP. 2003. Neurobiology of aging. 24: 95-103 A1 Journal article (refereed), original research

The density of endothelial cells in brain tissue is influenced by gender, age and concomitant brain pathology

Berdel B, Koivisto A, Soininen H, Laakso M, Alafuzoff I. 2003. BRAIN AGING. 3: 29-32 A1 Journal article (refereed), original research

Amygdaloid atrophy in frontotemporal dementia and Alzheimer¿s disease

Boccardi M, Pennanen C, Laakso MP, Testa C, Geroldi C, Soininen H, Frisoni GB. 2002. Neuroscience letters. 335: 139-143 A1 Journal article (refereed), original research

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H. 2002. Annals of internal medicine. 137: 149-155 A1 Journal article (refereed), original research

Auditory adaptation is differentially impaired in familial and sporadic Alzheimer`s disease

Tarkka IM, Lehtovirta M, Soininen H, Pääkkönen A, Karhu J, Partanen J. 2002. Biomedicine and pharmacotherapy. 56: 45-49 A1 Journal article (refereed), original research

Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T. 2002. Biochemical and biophysical research communications. 298: 693-698 A1 Journal article (refereed), original research

Detection of grey matter loss in mild Alzheimer¿s disease with voxel based morphometry

Frisoni GB, Testa C, Zorzan A, Sabattoli F, Beltramello A, Soininen H, Laakso MP. 2002. Journal of neurology neurosurgery and psychiatry. 73: 657-664 A1 Journal article (refereed), original research

EEG as a diagnostic tool in dementia

Soininen H, Partanen J. Teoksessa: Qizilbash N, Schneider LS, Chui H, Tariot P, Brodaty H, Kaye J, Erkinjuntti T(toim.) , 2002. Evidence-based Dementia Practice. s. 170-175. Blackwell A3 Book section, Chapters in research books

Hypertension and hypercholesterolaemia as risk factors for Alzheimer¿s disease: potential for pharmacological intervention

Kivipelto M, Laakso MP, Tuomilehto J, Nissinen A, Soininen H. 2002. Cns drugs. 16: 435-444 A1 Journal article (refereed), original research

Hypertension and white matter lesions of the brain

Kivipelto M, Soininen H, Tuomilehto J. 2002. Journal of hypertension. 20: 387-389 A1 Journal article (refereed), original research

Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T. 2002. MOLECULAR BRAIN RESEARCH. 106: 50-56 A1 Journal article (refereed), original research

Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease

Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Dementia and geriatric cognitive disorders. 14: 123-127 A1 Journal article (refereed), original research

Midlife income, occupation, APOE status, and dementia

Anttila T, Helkala E-L, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Mannermaa A, Tuomilehto J, Soininen H, Nissinen A. 2002. Neurology. 59: 887-893 A1 Journal article (refereed), original research

Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland

Autere JM, Hiltunen MJ, Mannermaa A, Jäkälä PA, Hartikainen PH, Majamaa K, Alafuzoff I, Soininen HS. 2002. European journal of neurology. 9: 479-483 A1 Journal article (refereed), original research

Muistihäiriö: normaalia ikääntymistä vai dementiaa

Soininen H, Hänninen T. 2002. Lääkärilehti. 57: 2183-2185 A2 Review article, Literature review, Systematic review

Neuropathology and ethiopathogenesis of Alzheimer¿s disease

Alafuzoff I, Soininen H. Teoksessa: Qizilbash N, Sneider LS, Chui H, Tariot P, Brodaty H, Kaye J, Erkinjuntti T(toim.) , 2002. Evidence-based Dementia Practice. s. 244-259. Blackwell A3 Book section, Chapters in research books

Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism

Laakso MP, Gunning-Dixon F, Vaurio O, Repo-Tiihonen E, Soininen H, Tiihonen J. 2002. Psychiatry research: neuroimaging. 114: 95-102 D1 Article in a trade journal

Prevalence of mild cognitive impairment: a population-based study in elderly subjects

Hänninen T, Hallikainen M, Tuomainen S, Vanhanen M, Soininen H. 2002. Acta neurologica scandinavica. 106: 148-154 A1 Journal article (refereed), original research

Radial width of the temporal horn: a sensitive measure in Alzheimer disease

Frisoni GB, Geroldi C, Beltramello A, Bianchetti A, Binetti G, Bordiga G, DeCarli C, Laakso MP, Soininen H, Testa C, Zanetti O, Trabucchi M. 2002. American journal of neuroradiology. 23: 35-47 D1 Article in a trade journal

Relevance of APOE genotype in diagnostics and therapy of Alzheimer¿s disease

Soininen H. 2002. REVIEW SERIES. DEMENTIA. : 15-18 A1 Journal article (refereed), original research

Seladin-1 transcription is linked to neuronal degeneration in Alzheimer¿s disease

Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, Soininen H. 2002. Neuroscience. 113: 301-310 A1 Journal article (refereed), original research

Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure - a population-based study

Helkala E-L, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Tuomilehto J, Soininen H, Nissinen A. 2002. Acta neurologica scandinavica. 106: 341-346 A1 Journal article (refereed), original research

Vascular risk factors, ApoE epsilon4 allele, and gender and the risk of Alzheimer¿s disease: perspectives on prevention

Kivipelto M, Helkala E-L, Nissinen A, Soininen H, Tuomilehto J. 2002. Drug development research. 56: 85-94 A1 Journal article (refereed), original research

A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD

Winblad B, Engedal K, Soininen H, Verhey F, Waldemar G, Wimo A, Wetterholm A-L, Zhang R, Haglund A, Subbiah P, the Donepezil Nordic Study Group, Hallikainen M, Jäkälä P, Riekkinen M. 2001. Neurology. 57: 489-495 A1 Journal article (refereed), original research

APOE-epsilon4 is associated with weight loss in women with AD. A population-based study

Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M. 2001. Neurology. 56: 655-659 A1 Journal article (refereed), original research

An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin

Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. Neurogenetics

Benefits of donepezil on cognition, function and neuropsychiatric symptoms in patients with mild and moderate Alzheimr¿s disease over one year

Waldemar G, Winblad B, Engedal K, Soininen H, Verhey F, Wimo A, Wetterholm A-L, Zhang R, Haglund A, Subbiah P, The Donepezil Nordic Study Group. Teoksessa: Igbal K, Sisodia SS, Winblad B(toim.) , 2001. Alzheimer¿s Disease: Advances in Ethiology, Pathogenesis and Therapeutics. s. 725-738. John Wiley & Sons A3 Book section, Chapters in research books

Beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality

Kerokoski P, Soininen H, Pirttilä T. 2001. Neurochemistry international. 38: 127-134 A1 Journal article (refereed), original research

CSF tau and Abeta42 levels in patients with Down¿s syndrome

Tapiola T, Soininen H, Pirttilä T. 2001. Neurology. 56: 979 A1 Journal article (refereed), original research

Genes, proteins and brain disease

Hiltunen M, Soininen H. 2001. Trends in molecular medicine. 7: 382-383 A2 Review article, Literature review, Systematic review

Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland

Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Neurology. 57: 1663-1668 A1 Journal article (refereed), original research

Hippocampal plasticity in Alzheimer¿s disease

Mikkonen M, Soininen H, Alafuzoff I, Miettinen R. 2001. Reviews in the neurosciences. 12: 311-325 A1 Journal article (refereed), original research

Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNA

Finnilä S, Autere J, Lehtovirta M, Hartikainen P, Mannermaa A, Soininen H, Majamaa K. 2001. Journal of medical genetics

Kliinis-neurofysiologiset tutkimukset

Soininen H, Partanen J. Teoksessa: Erkinjuntti T, Rinne J, Alhainen K, Soininen H(toim.) , 2001. Muistihäiriöt ja dementia. s. 403-409. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Midlife vascular risk factors and Alzheimer¿s disease in later life: longitudinal, population based study

Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissien A. 2001. BMJ international edition. 322: 1447-1451 A1 Journal article (refereed), original research

Midlife vascular risk factors and late-life mild cognitive impairment. A population-based study

Kivipelto M, Helkala E-L, Hänninen T, Laakso MP, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A. 2001. Neurology. 56: 1683-1689 A1 Journal article (refereed), original research

Muistihäiriöiden ja dementian ennaltaehkäisy

Soininen H. Teoksessa: Erkinjuntti T, Rinne J, Alhainen K, Soininen H(toim.) , 2001. Muistihäiriöt ja dementia. s. 435-441. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Muistihäiriöiden oirediagnostiikka

Soininen H, Hänninen T. Teoksessa: Erkinjuntti T, Rinne J, Alhainen K, Soininen H(toim.) , 2001. Muistihäiriöt ja dementia. s. 77-87. Helsinki D2 Article in a professional book (incl. an introduction by the editor)

Muistihäiriöt ja dementia

Erkinjuntti T, Rinne J, Soininen H. Teoksessa: Soinila S, Kaste M, Launes J, Somer H(toim.) , 2001. Duodecim. s. 322-341. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Muistihäiriöt ja dementia

Erkinjuntti T, Rinne J, Alhainen K, Soininen H. 2001. . . Duodecim D6 Edited professional book

Psychopathy and the posterior hippocampus

Laakso MP, Vaurio O, Koivisto E, Savolainen L, Eronen M, Aronen HJ, Hakola P, Repo E, Soininen H, Tiihonen J. 2001. Behavioural brain research. 118: 187-193 A1 Journal article (refereed), original research

Tacrine may alter APP-like protein levels in the lumbar CSF of Alzheimer patients

Clarke NA, Soininen H, Gustafson L, Minthon L, Alhainen K, Francis PT. 2001. International journal of geriatric psychiatry. 16: 1104-1106 A1 Journal article (refereed), original research

The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T. 2001. Biochemical and biophysical research communications. 280: 998-1002 A1 Journal article (refereed), original research

The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer¿s disease

Kraszpulski M, Soininen H, Helisalmi S, Alafuzoff I. 2001. Acta neurologica scandinavica. 103: 88-92 A1 Journal article (refereed), original research

alpha-Synuclein pathology is highly dependent on the case selection

Parkkinen L, Soininen H, Laakso M, Alafuzoff I. 2001. Neuropathology and applied neurobiology. 27: 314-325 A1 Journal article (refereed), original research

A longitudinal quantitative EEG study of Alzheimer¿s disease: relation to apolipoprotein E polymorphism

Lehtovirta M, Partanen J, Könönen M, Hiltunen J, Helisalmi S, Hartikainen P, Riekkinen P Sr, Soininen H. 2000. Dementia and geriatric cognitive disorders. 11: 29-35 A1 Journal article (refereed), original research

A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism

Laakso MP, Vaurio O, Savolainen L, Repo E, Soininen H, Aronen HJ, Tiihonen J. 2000. Behavioural brain research. 109: 177-186 A1 Journal article (refereed), original research

APOE4 relevance to early diagnosis and treatment of Alzhemer¿s disease

Soininen H. Teoksessa: Battistin L, Korczyn AD(toim.) , 2000. 5th Congress of the European Society for Clinical Neuropharmacology. s. 124-130. Monduzzi A4 Conference proceedings

Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer¿s disease: a volumetric MRI study

Geroldi C, Laakso MP, DeCarli C, Beltramello A, Biancetti A, Soininen H, Trabucchi M, Frisoni GB. 2000. Journal of neurology neurosurgery and psychiatry. 68: 93-96 A1 Journal article (refereed), original research

Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study

Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. 2000. Neuroepidemiology. 19: 327-332 A1 Journal article (refereed), original research

DNA fragmentation, gliosis and histological hallmarks of Alzheimer¿s disease

Overmyer M, Kraszpulski M, Helisalmi S, Soininen H, Alafuzoff I. 2000. Acta neuropathologica. 100: 681-687 A1 Journal article (refereed), original research

Diagnosis of Alzheimer`s disease: MRI of the hippocampus vs delayed recall

Laakso MP, Hallikainen M, Hänninen T, Partanen K, Soininen H. 2000. Neuropsychologia. 38: 579-584 A1 Journal article (refereed), original research

Early diagnosis of Alzheimer¿s disease

Soininen H. 2000. PATHWAYS: THE NOVARTIS JOURNAL

Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer¿s disease: a morphometric MRI study

Laakso MP, Frisoni GB, Könönen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. 2000. Biological psychiatry. 47: 1056-1063 A1 Journal article (refereed), original research

Hippocampus in Alzheimer¿s disease: A 3-year follow-up MRI study

Laakso MP, Lehtovirta M, Partanen K, Riekkinen PJ Sr, Soininen H. 2000. Biological psychiatry. 47: 557-561 A1 Journal article (refereed), original research

How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer¿s disease ? A review of neuroimaging studies

Lehtovirta M, Laakso MP, Frisoni GB, Soininen H. 2000. Neurobiology of aging. 21: 293-300 A1 Journal article (refereed), original research

Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination?

Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. European journal of human genetics. 8: 259-266 A1 Journal article (refereed), original research

Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts

Fratiglioni L, Launer LJ, Andersen K, Breteler MMB, Copeland JRM, Dartigues J-F, Lobo A, Martinez-Lage J, Soininen H, Hofman A, for the Neurologic Diseases in the Elderly Research Group. 2000. NEUROLOGY. SUPPLEMENT. 54: S10-S15 A1 Journal article (refereed), original research

Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer¿s disease?

Helisalmi S, Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Alafuzoff I, Ryynänen M, Soininen H. 2000. Neuroscience letters. 278: 65-68 A1 Journal article (refereed), original research

La rilevazione delle alterazioni strutturali cerebrali nella malttia di Alzheimer: tecniche e strumenti

Scheltens P, Wahlund L-O, Soininen H, Laakso M, Partanen K, Resconi G, Rossini PM, Tecchio F, Fox N. Teoksessa: Frisoni GB, Trabucchi M(toim.) , 2000. Il neuroimaging nella diagnosi di malattia di Alzheimer, Problemi, strumenti, linee-guida. s. 21-34. Il Pensiero Scientifico Editore A3 Book section, Chapters in research books

Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs

Alafuzoff I, Overmyer M, Helisalmi S, Soininen H. 2000. Journal of Alzheimer's disease. 2: 37-46 A1 Journal article (refereed), original research

MR imaging of the hippocampus in normal pressure hydrocephalus: correlations with cortical Alzheimer`s disease confirmed by pathologic analysis

Savolainen S, Laakso MP, Paljärvi L, Alafuzoff I, Hurskainen H, Partanen K, Soininen H, Vapalahti M. 2000. American journal of neuroradiology. 21: 409-414 A1 Journal article (refereed), original research

Mild cognitive impairment as a warning sign of dementia

Hänninen T, Soininen H. Teoksessa: Vellas B, Fitten LJ(toim.) , 2000. Research and Practice in Alzheimer¿s Disease. s. 93-97. Springer A3 Book section, Chapters in research books

Milloin aivot tulee kuvata

Soininen H, Sulkava R. 2000. Duodecim

Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow

Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R. 2000. Neuroscience. 96: 515-522 A1 Journal article (refereed), original research

Muistihäiriö- ja dementiapotilaan toimintakyvyn ja sairauden vaikeusasteen arviointi

Suomen muistitutkimusyksiköiden asiantuntijatyöryhmä, Rosenvall A, Viramo P, Juva K, Alhainen K, Koivisto K, Pirttilä T, Rinne J, Saarela T, Soininen H, Vanhanen M, Erkinjuntti T. 2000. Lääkärilehti. 55: 2299-2304 A2 Review article, Literature review, Systematic review

Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts

Lobo A, Launer LJ, Fratiglioni L, Andersen K, Carlo AD, Breteler MMB, Copeland JRM, Dartigues J-F, Jagger C, Martinez-Lage J, Soininen H, Hofman A, for the Neurologic Diseases in the Elderly Research Group. 2000. NEUROLOGY. SUPPLEMENT. 54: S4-S9 A1 Journal article (refereed), original research

Prognosis with dementia in Europe: a collaborative study of population-based cohorts

Jagger C, Andersen K, Breteler MMB, Copeland JRM, Helmer C, Baldereschi M, Fratiglioni L, Lobo A, Soininen H, Hofman A, Launer LJ, for the Neurolgic Diseases in the Elderly Research Group. 2000. NEUROLOGY. SUPPLEMENT. 54: S16-S20 A1 Journal article (refereed), original research

Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer¿s disease

Tapiola T, Pirttilä T, Mehta PD, Alafuzoff I, Lehtovirta M, Soininen H. 2000. Neurobiology of aging. 21: 735-740 A1 Journal article (refereed), original research

Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer¿s disease

Alafuzoff I, Helisalmi S, Heinonen EH, Reinikainen K, Hallikainen M, Soininen H, Koivisto K. 2000. European journal of clinical pharmacology. 55: 815-819 A1 Journal article (refereed), original research

Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia

Alafuzoff I, Helisalmi S, Mannermaa A, Soininen H. 2000. Annals of the New York Academy of Sciences. 903: 244-251 A1 Journal article (refereed), original research

The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with Alzheimer¿s disease or the link apolipoprotein E

Helisalmi S, Valve R, Karvonen MK, Hiltunen M, Pirskanen M, Mannermaa A, Koulu M, Pesonen U, Uusitupa M, Soininen H. 2000. Neuroscience letters. 287: 25-28 A1 Journal article (refereed), original research

Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and concentration in Alzheimer¿s disease

Tapiola T, Pirttilä T, Mikkonen M, Mehta PD, Alafuzoff I, Koivisto K, Soininen H. 2000. Neuroscience letters. 280: 119-122 A1 Journal article (refereed), original research

Varhaisen dementian kuvantamisdiagnostiikka

Partanen K, Laakso M, Erkinjuntti T, Soininen H. 2000. Duodecim. 116: 1049-1058 A2 Review article, Literature review, Systematic review

Vascular dementia and white matter changes: electrophyciological tests

Partanen J, Soininen H, Riekkinen P. Teoksessa: Pantoni L, Inzitari D, Wallin A(toim.) , 2000. The Matter of White Matter. s. 171-178. Academic Pharmaceutical Productions D2 Article in a professional book (incl. an introduction by the editor)

Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study

Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Laakso M, Partanen K, Soininen H, Aronen HJ. 2000. Annals of neurology. 47: 470-476 A1 Journal article (refereed), original research

APOE type and MRI volumetric changes as predictor of Alzheimer¿s disease

Soininen HS, Riekkinen P Sr. Teoksessa: Vellas B, Fitten LJ(toim.) , 1999. Research and Practice in Alzheimer¿s Disease. s. 95-98. Springer A3 Book section, Chapters in research books

APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD

Geroldi C, Pihlajamäki M, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, Trabucchi M, Frisoni GB. 1999. Neurology. 53: 1825-1832 A1 Journal article (refereed), original research

Astrogliosis and the ApoE genotype: an immunohistochemical study of postmortem human brain tissue

Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Dementia and geriatric cognitive disorders. 10: 252-257 A1 Journal article (refereed), original research

Beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients

Alafuzoff I, Helisalmi S, Mannermaa A, Riekkinen P Sr, Soininen H. 1999. Stroke. 30: 613-618 A1 Journal article (refereed), original research

Beta-amyloid load, astroglia and microglia in Alzheimer¿s disease: association with apoE genotype

Alafuzoff I, Overmyer M, Helisalmi S, Riekkinen P Sr, Soininen H. 1999. ALZHEIMER'S RESEARCH. 2: 283-289 A1 Journal article (refereed), original research

Cerebrospinal fluid aspartate aminotransferase activity is increased in Alzheimer¿s disease

Tapiola T, Lehtovirta M, Pirttilä T, Alafuzoff I, Riekkinen P Sr, Soininen H. Teoksessa: Iqbal K, Swaab DF, Winblad B, Wisniewski HM(toim.) , 1999. Alzheimer¿s Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics. s. 193-197. John Wiley & Sons A3 Book section, Chapters in research books

Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease

Juottonen K, Laakso MP, Partanen K, Soininen H. 1999. American journal of neuroradiology. 20: 139-144 A1 Journal article (refereed), original research

Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer¿s disease

Frisoni GB, Laakso MP, Beltramello A, Geroldi C, Bianchetti A, Soininen H, Trabucchi M. 1999. Neurology. 52: 91-100 A1 Journal article (refereed), original research

Hippocampal plasticity in Alzheimer¿s disease: changes in highly polysialylated NCAM immunoreactivity in the hippocampal formation

Mikkonen M, Soininen H, Tapiola T, Alafuzoff I, Miettinen R. 1999. European journal of neuroscience. 11: 1754-1764 A1 Journal article (refereed), original research

Kognitiiviset testit muistihäiriöiden ja alkavan dementian varhaisdiagnostiikassa: CERAD-tehtäväsarja

Hänninen T, Pulliainen V, Salo J, Hokkanen L, Erkinjuntti T, Koivisto K, Viramo P, Soininen H, Suomen muistitutkimusyksiköiden asiantuntijaryhmä. 1999. Lääkärilehti. 54: 1967-1975 A2 Review article, Literature review, Systematic review

Kuka on vaarassa sairastua Alzheimerin tautiin ?

Soininen H, Hänninen T. 1999. Lääkärilehti. 54: 1519-1523 A2 Review article, Literature review, Systematic review

Lievä kognitiivinen heikentyminen dementian varhaisena merkkinä

Hänninen T, Soininen H. 1999. Duodecim. 115: 381-388 A2 Review article, Literature review, Systematic review

Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer`s disease patients

Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Helisalmi S, Ryynänen M, Riekkinen P Sr, Soininen H. 1999. European journal of human genetics. 7: 652-658 A1 Journal article (refereed), original research

Prognosis with dementia: results from a European collaborative analysis of population-based studies

Jagger C, Andersen K, Breteler MMB, Copeland RJM, Dartigues J-F, Di Carlo A, Fratiglioni L, Lobo A, Schmidt R, Soininen H, Hofman A, Launer LJ. Teoksessa: Iqbal K, Swaab DF, Winblad B, Wisniewski HM(toim.) , 1999. Alzheimer¿s Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics. s. 39-44. John Wiley & Sons A3 Book section, Chapters in research books

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer¿s disease patients and control individuals

Helisalmi S, Hiltunen M, Valonen P, Mannermaa A, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 1999. Journal of neurology. 246: 821-824 A1 Journal article (refereed), original research

Rapidly progressive multifocal leukoencephalopathy with substantial cell-mediated inflammatory response and with cognitive decline of non-Alzheimer type in a 75-year-old female patient

Alafuzoff I, Hartikainen P, Hanninen T, Partanen K, Kuikka J, Syrjänen K, Naukkarinen A, Soininen H. 1999. Clinical neuropathology. 18: 113-123 A1 Journal article (refereed), original research

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue

Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Acta neuropathologica. 97: 383-392 A1 Journal article (refereed), original research

Regional differences in the incidence of dementia in Europe: EURODEM collaborative analyses

Launer LJ, Fratiglioni L, Andersen K, Breteler MMB, Copeland RJM, Dartigues J-F, Lobo A, Martinez-Lage J, Soininen H, Hofman A. Teoksessa: Iqbal K, Swaab DF, Winblad B, Wisniewski HM(toim.) , 1999. Alzheimer¿s Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics. s. 9-15. John Wiley & Sons A3 Book section, Chapters in research books

Subfield- and layer-specific changes in parvalbumin, calretinin and calbindin-D28k immunoreactivity in the entorhinal cortex in Alzheimer`s disease

Mikkonen M, Alafuzoff I, Tapiola T, Soininen H, Miettinen R. 1999. Neuroscience. 92: 515-532 A1 Journal article (refereed), original research

Type-2 diabetes and cognitive function in a non-demented population

Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1999. Acta neurologica scandinavica. 100: 97-101 A1 Journal article (refereed), original research

ApoE and memory in Alzheimer¿s disease

Soininen HS, Riekkinen PJ Sr. Teoksessa: Fisher A, Hanin I, Yoshida M(toim.) , 1998. Progress in Alzheimer¿s and Parkinson¿s Diseases. s. 13-16. Plenum A3 Book section, Chapters in research books

Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer¿s disease patients

Hiltunen M, Mannermaa A, Helisalmi S, Koivisto A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Neuroscience letters. 250: 69-71 A1 Journal article (refereed), original research

CSF tau is related to apolipoprotein E genotype in early Alzheimer's disease

Tapiola T, Lehtovirta M, Ramberg J, Helisalmi S, Linnaranta K, Riekkinen P Sr, Soininen H. 1998. Neurology. 50: 169-174 A1 Journal article (refereed), original research

Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala

Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1998. Brain research. 783: 355-358 A1 Journal article (refereed), original research

Cognitive function in an elderly population with persistent impaired glucose tolerance

Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1998. Diabetes care. 21: 398-402 A1 Journal article (refereed), original research

Consensus report of the working group on: Molecular and biochemical markers of Alzheimer¿s disease

The Ronald and Nancy Reagan Research Institute of the Alzheimer's ..., Riekkinen PJ, Soininen HS. 1998. Neurobiology of aging. 19: 109-116 A1 Journal article (refereed), original research

Early diagnostic indices for the prevention of Alzheimer¿s disease

Soininen HS, Scheltens P. 1998. Annals of medicine. 30: 553-559 A1 Journal article (refereed), original research

Glucose intolerance, cognitive impairment and Alzheimer¿s disease

Vanhanen M, Soininen H. 1998. Current opinion in neurology. 11: 673-677 A1 Journal article (refereed), original research

Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson`s disease patients

Riekkinen P Jr, Kejonen K, Laakso MP, Soininen H, Partanen K, Riekkinen M. 1998. Neuroreport. 9: 1507-1511 A1 Journal article (refereed), original research

Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer¿s disease

Tapiola T, Lehtovirta M, Pirttilä T, Alafuzoff I, Riekkinen P, Soininen H. 1998. The Lancet

Longitudinal SPECT study in Alzheimer`s disease: relation to apolipoprotein E polymorphism

Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 64: 742-746 A1 Journal article (refereed), original research

Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer`s disease

Pirttilä T, Koivisto K, Mehta PD, Reinikainen K, Kim KS, Kilkku O, Heinonen E, Soininen H, Riekkinen P Sr, Wisniewski HM. 1998. Neuroscience letters. 249: 21-24 A1 Journal article (refereed), original research

MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices

Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A. 1998. American journal of neuroradiology. 19: 659-671 A1 Journal article (refereed), original research

MRI of the hippocampus in Alzheimer`s disease: sensitivity, specificity, and analysis of the incorrectly classified subjects

Laakso MP, Soininen H, Partanen K, Lehtovirta M, Hallikainen M, Hänninen T, Helkala E-L, Vainio P, Riekkinen PJ Sr. 1998. Neurobiology of aging. 19: 23-31 A1 Journal article (refereed), original research

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer`s disease carrying the apolipoprotein E epsilon4 allele

Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen PJ Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 65: 322-327 A1 Journal article (refereed), original research

Pitfalls in the quantitative estimation of beetta-amyloid immunoreactivity in human brain tissue

Kraszpulski M, Soininen H, Riekkinen P Sr, Alafuzoff I. 1998. Histochemistry and cell biology. 110: 439-445 A1 Journal article (refereed), original research

Reduction of noradrenaline impairs attention and dopamine depletion slows responses in Parkinson`s disease

Riekkinen M, Kejonen K, Jäkälä P, Soininen H, Riekkinen P Jr. 1998. European journal of neuroscience. 10: 1429-1435 A1 Journal article (refereed), original research

Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex

Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A. 1998. Annals of neurology. 44: 923-934 A1 Journal article (refereed), original research

Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease

Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H. 1998. Neurobiology of aging. 19: 15-22 A1 Journal article (refereed), original research

Age-associated memory impairment Normal aging or warning of dementia?

Hänninen T, Soininen H. 1997. Drugs and aging. 11: 480-489 A1 Journal article (refereed), original research

Alzheimerin taudin hoito

Soininen H. 1997. Duodecim. 113: 1739-1746 A2 Review article, Literature review, Systematic review

Alzheimerin taudin perinnöllisyys

Lehtovirta M, Soininen H. 1997. Lääkärilehti. 52: 177-180 D1 Article in a trade journal

Apolipoprotein E and temporal lobe pathology: magnetic resonance imaging and population-based studies

Riekkinen PJ Sr, Soininen HS. Teoksessa: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM(toim.) , 1997. Alzheimer`s Disease: Biology, Diagnosis and Therapeutics. s. 145-148. John Wiley & Sons A3 Book section, Chapters in research books

Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains

Pirttilä T, Soininen H, Mehta PD, Heinonen O, Lehtimäki T, Bogdanovic N, Paljärvi L, Kim KS, Kosunen O, Winblad B, Riekkinen P Sr, Wisniewski HM. 1997. Neurobiology of aging. 18: 121-127 A1 Journal article (refereed), original research

Challenge of Alzheimer`s disease is taken in Finland

Soininen H. 1997. UNFORGETTABLE. : 39-40 E1 Popularised article, newspaper article

Decline of frontal lobe functions in subjects with age-associated memory impairment

Hänninen T, Hallikainen M, Koivisto K, Partanen K, Laakso MP, Riekkinen PJ Sr, Soininen H. 1997. Neurology. 48: 148-153 A1 Journal article (refereed), original research

Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex

Mikkonen M, Soininen H, Pitkänen A. 1997. Journal of comparative neurology. 388: 64-88 A1 Journal article (refereed), original research

Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence

Salminen A, Helenius M, Lahtinen T, Korhonen P, Tapiola T, Soininen H, Solovyan V. 1997. Biochemical and biophysical research communications. 238: 712-716 A1 Journal article (refereed), original research

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Van Duijn CM, for the APOE and Alzheimer Disease Meta Analysis Consorium, Koivisto K, Lehtovirta M, Riekkinen P Sr, Kuusisto J, Laakso M, Soininen H. 1997. JAMA : Journal of the American Medical Association. 278: 1349-1356 A1 Journal article (refereed), original research

Fragile-X: Neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes

Jäkälä P, Hänninen T, Ryynänen M, Laakso M, Partanen K, Mannermaa A, Soininen H. 1997. Journal of clinical investigation. 100: 331-338 A1 Journal article (refereed), original research

Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease

Riekkinen P Jr, Riekkinen M, Soininen H, Kuikka J, Laakso M, Riekkinen P Sr. 1997. Neuroreport. 8: 1845-1849 A1 Journal article (refereed), original research

Glutamate-induced changes in the DNA-binding complexes of transcription factor YY1 in cultured hippocampal and cerebellar granule cells

Korhonen P, Huotari V, Soininen H, Salminen A. 1997. MOLECULAR BRAIN RESEARCH. 52: 330-333 A1 Journal article (refereed), original research

Lack of association between presenilin-1 polymorphism, Alzheimer's disease and apolipoprotein E

Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. ALZHEIMER'S RESEARCH. 3: 159-161 A1 Journal article (refereed), original research

MRI volumetry of the hippocampus: the effect of slice thickness on volume formation

Laakso MP, Juottonen K, Partanen K, Vainio P, Soininen H. 1997. Magnetic resonance imaging. 15: 263-265 A1 Journal article (refereed), original research

No association between alfa1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer`s disease

Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. Neuroscience letters. 231: 56-58 A1 Journal article (refereed), original research

Relationship between EEG reactivity and neuropsychological tests in vascular dementia

Partanen J, Soininen H, Helkala E-L, Könönen M, Kilpeläinen R, Riekkinen P. 1997. Journal of neural transmission. 104: 905-912 A1 Journal article (refereed), original research

Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function

Vanhanen M, Koivisto K, Karjalainen L, Helkala E-L, Laakso M, Soininen H, Riekkinen P Sr. 1997. Neuroreport. 8: 1527-1530 A1 Journal article (refereed), original research

THA disrupts mismatch negativity in Alzheimer disease

Riekkinen P Jr, Pääkkönen A, Karhu J, Partanen J, Soininen H, Laakso M, Riekkinen P Sr. 1997. Psychopharmacology. 133: 203-206 A1 Journal article (refereed), original research

The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients

Riekkinen P Jr, Soininen H, Partanen J, Pääkkönen A, Helisalmi S, Riekkinen P Sr. 1997. Psychopharmacology. 129: 285-288 A1 Journal article (refereed), original research

The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer`s disease

Tapiola T, Overmyer M, Lehtovirta M, Helisalmi S, Ramberg J, Alafuzoff I, Riekkinen P Sr, Soininen H. 1997. Neuroreport. 8: 3961-3963 A1 Journal article (refereed), original research

ApoE and Alzheimer`s disease-neuropathological, MRI and polpulation-based studies

Soininen H. Teoksessa: Salonen T, Sivenius J, Sirviö J, Riekkinen P Jr, Salminen A(toim.) , 1996. 20 Years of Brain Research in Kuopio. s. 37-40. Kuopio University, Department of Neuroscience and Neur... A3 Book section, Chapters in research books

ApoE genotype and MRI volumetry: implication for therapy

Soininen HS, Lehtovirta M, Laakso MP, Partanen K, Riekkinen P Jr, Hallikainen M, Hänninen T, Koivisto K, Riekkinen PJ Sr. Teoksessa: Becker R, Giacobini E(toim.) , 1996. Alzheimer Disease: From Molecular Biology to Therapy. s. 475-480. Birkhäuser A3 Book section, Chapters in research books

Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls

Pirttilä T, Soininen H, Heinonen O, Lehtimäki T, Bogdanovic N, Paljärvi L, Kosunen O, Winblad B, Riekkinen P Sr, Wisniewski HM, Mehta PD. 1996. Brain research. 722: 71-77 A1 Journal article (refereed), original research

Apolipoprotein E epsilon4 allele - a risk factor for Alzheimer`s disease and hippocampal volume loss

Soininen H. 1996. TEKNIA JOURNAL. : 12-13 D1 Article in a trade journal

Apolipoprotein E polymorphism in patients with different neurodegenerative disorders

Helisalmi S, Linnaranta K, Lehtovirta M, Mannermaa A, Heinonen O, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters. 205: 61-64 A1 Journal article (refereed), original research

Apolipoprotein E, memory and Alzheimer's disease

Soininen HS, Riekkinen PJ Sr. 1996. Trends in neurosciences. 19: 224-228 A1 Journal article (refereed), original research

Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex

Sorvari H, Soininen H, Pitkänen A. 1996. Neuroscience. 75: 421-443 A1 Journal article (refereed), original research

Calretinin-immunoreactive cells and fibers in the human amygdaloid complex

Sorvari H, Soininen H, Pitkänen A. 1996. Journal of comparative neurology. 369: 188-208 A1 Journal article (refereed), original research

Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease

Pirttilä T, Mehta PD, Soininen H, Kim KS, Heinonen O, Paljärvi L, Kosunen O, Riekkinen P Sr, Wisniewski HM. 1996. Archives of neurology. 53: 189-193 A1 Journal article (refereed), original research

Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism

Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ Sr. 1996. Neurology. 46: 413-419 A1 Journal article (refereed), original research

Diagnostic accuracy of Alzheimer's disease: a neuropathological study

Kosunen O, Soininen H, Paljärvi L, Heinonen O, Talasniemi S, Riekkinen PJ Sr. 1996. Acta neuropathologica. 91: 185-193 A1 Journal article (refereed), original research

EEG reactivity correlates with neuropsychological test scores in Down's syndrome

Partanen J, Soininen H, Könönen M, Kilpeläinen R, Helkala E-L, Riekkinen P Sr. 1996. Acta neurologica scandinavica. 94: 242-246 A1 Journal article (refereed), original research

Electrophysiological tests

Petit D, Montplaisir J, Riekkinen P Sr, Soininen H, Riekkinen P Jr. Teoksessa: Gauthier S(toim.) , 1996. Clinical Diagnosis and Management of Alzheimer's Disease. s. 107-126. Martin Duniz A3 Book section, Chapters in research books

Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: an MRI study

Laakso MP, Partanen K, Riekkinen P Jr, Lehtovirta M, Helkala E-L, Hallikainen M, Hänninen T, Vainio P, Soininen H. 1996. Neurology. 46: 678-681 A1 Journal article (refereed), original research

MR T2 relaxometry in Alzheimer's disease and age-associated memory impairment

Laakso MP, Partanen K, Soininen H, Lehtovirta M, Hallikainen M, Hänninen T, Helkala E-L, Vainio P, Riekkinen PJ Sr. 1996. Neurobiology of aging. 17: 535-540 A1 Journal article (refereed), original research

Muistihäiriöt ja dementia

Suomen muistitutkimusyksiköiden asiantuntijaryhmä, Erkinjuntti T, Alhainen K, Frey H, Helkala E-L, Hervonen A, Hietanen M, Juva K, Kivelä S-L, Koponen H, Koivisto K, Majamaa K, Myllylä V, Pirttilä T, Reinikainen KJ, Riekkinen P Jr, Rinne J, Saarela T. 1996. Lääkärilehti. 51: 2949-2957 D1 Article in a trade journal

Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study

Sorvari H, Miettinen R, Soininen H, Pitkänen A. 1996. Neuroscience letters. 217: 93-96 A1 Journal article (refereed), original research

Prevalence of ageing-associated cognitive decline in an elderly population

Hänninen T, Koivisto K, Reinikainen KJ, Helkala E-L, Soininen H, Mykkänen L, Laakso M, Riekkinen PJ. 1996. Age and ageing. 25: 201-205 A1 Journal article (refereed), original research

SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon4 allele

Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, Ryynänen M, Kuikka J, Hartikainen P, Riekkinen PJ Sr. 1996. Journal of neurology neurosurgery and psychiatry. 60: 644-649 A1 Journal article (refereed), original research

Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease

Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters. 205: 68-70 A1 Journal article (refereed), original research

Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease

Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H. 1996. Neurology. 46: 1724-1730 A1 Journal article (refereed), original research

Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer`s disease patiens

Helkala E-L, Hänninen T, Könönen M, Hartikainen P, Partanen J, Partanen K, Vainio P, Hallikainen M, Laakso MP, Soininen H, Riekkinen P Sr. 1996. Behavioral neuroscience. 110: 1235-1243 A1 Journal article (refereed), original research

Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism

Lehtovirta M, Partanen J, Könönen M, Soininen H, Helisalmi S, Mannermaa A, Ryynänen M, Hartikainen P, Riekkinen P Sr. 1996. Neurobiology of aging. 17: 523-526 A1 Journal article (refereed), original research

A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia

Hänninen T, Hallikainen M, Koivisto K, Helkala E-L, Reinikainen KJ, Soininen H, Mykkänen L, Laakso M, Pyörälä K, Riekkinen PJ Sr. 1995. Journal of the american geriatrics society. 43: 1007-1015 A1 Journal article (refereed), original research

A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein e4 allele

Soininen H, Kosunen O, Helisalmi S, Mannermaa A, Paljärvi L, Talasniemi S, Ryynänen M, Riekkinen P Sr. 1995. Neuroscience letters. 187: 79-82 A1 Journal article (refereed), original research

Alzheimer pathology of patients carrying apolipoprotein E epsilon4 allele

Heinonen O, Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Sorvari H, Kosunen O, Paljärvi L, Ryynänen M, Riekkinen PJ Sr. 1995. Neurobiology of aging. 16: 505-513 A1 Journal article (refereed), original research

Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland

Lehtovirta M, Helisalmi S, Mannermaa A, Soininen H, Koivisto K, Ryynänen M, Riekkinen P Sr. 1995. Neuroscience letters. 185: 13-15 A1 Journal article (refereed), original research

Beta-amyloid-protein immunoreactivity in skin is not a reliable marker of Alzheimer's disease: an autopsy controlled study

Heinonen O, Soininen H, Syrjänen S, Neittaanmäki H, Paljärvi L, Kosunen O, Talasniemi S, Syrjänen K, Riekkinen P Sr. Teoksessa: Hanin I, Yoshida M, Fisher A(toim.) , 1995. Alzheimer's and Parkinson's Diseases. s. 157-163. Plenum Press A3 Book section, Chapters in research books

Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele

Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Neurology. 45: 391-392 A1 Journal article (refereed), original research

Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex

Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1995. Journal of comparative neurology. 360: 185-212 A1 Journal article (refereed), original research

Habituation of auditory N100 correlates with amygdaloid volumes and frontal functions in age-associated memory impairment

Soininen HS, Karhu J, Partanen J, Pääkkönen A, Jousmäki V, Hänninen T, Hallikainen M, Partanen K, Laakso MP, Koivisto K, Riekkinen PJ Sr. 1995. Physiology and behavior. 57: 927-935 A1 Journal article (refereed), original research

Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease

Riekkinen P Jr, Soininen H, Helkala E-L, Partanen K, Laakso M, Vanhanen M, Riekkinen P. 1995. Neuroreport. 6: 1297-1300 A1 Journal article (refereed), original research

Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele

Soininen H, Lehtovirta M, Helisalmi S, Linnaranta K, Heinonen O, Riekkinen P Sr. 1995. Neuroreport. 6: 2518-2520 A1 Journal article (refereed), original research

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease

Heinonen O, Soininen H, Sorvari H, Kosunen O, Paljärvi L, Koivisto E, Riekkinen PJ Sr. 1995. Neuroscience. 64: 375-384 A1 Journal article (refereed), original research

MRI of amygdala fails to diagnose early Alzheimer's disease

Laakso MP, Partanen K, Lehtovirta M, Hallikainen M, Hänninen T, Vainio P, Riekkinen P Sr, Soininen H. 1995. Neuroreport. 6: 2414-2418 A1 Journal article (refereed), original research

Regional cerebral blood flow measured by 99mTC-HMPAO SPECT differs in subgroups of Alzheimer's disease

Soininen H, Helkala E-L, Kuikka J, Hartikainen P, Lehtovirta M, Riekkinen PJ Sr. 1995. Journal of neural transmission. 9: 95-109 A1 Journal article (refereed), original research

Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients

Kosunen O, Talasniemi S, Lehtovirta M, Heinonen O, Helisalmi S, Mannermaa A, Paljärvi L, Ryynänen M, Riekkinen PJ Sr, Soininen H. 1995. Stroke. 26: 743-748 A1 Journal article (refereed), original research

Tetrahydroaminoacridine modulates technetium-99m labelled ethylene dicysteinate retention in Alzheimer's disease measured with single photon emission computed tomography imaging

Riekkinen P Jr, Kuikka J, Soininen H, Helkala E-L, Hallikainen M, Riekkinen P. 1995. Neuroscience letters. 195: 53-56 A1 Journal article (refereed), original research

The interuncal distance in Alzheimer disease and age-associated memory impairment

Laakso M, Soininen H, Partanen K, Hallikainen M, Lehtovirta M, Hänninen T, Vainio P, Riekkinen PJ Sr. 1995. American journal of neuroradiology. 16: 727-734 A1 Journal article (refereed), original research

Volumes of hippocampus and amygdala in the magnetic resonance imaging based diagnosis of early Alzheimer's disease

Laakso MP, Soininen H, Helkala E-L, Hartikainen P, Partanen K, Vainio P, Riekkinen PJ Sr. Teoksessa: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM(toim.) , 1995. Research Advances in Alzheimer's Disease and Related Disorders. s. 181-188. John Wiley A3 Book section, Chapters in research books

Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes

Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Partanen K, Ryynänen M, Vainio P, Hartikainen P, Riekkinen PJ Sr. 1995. Neuroscience. 67: 65-72 A1 Journal article (refereed), original research

Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions

Laakso MP, Soininen H, Partanen K, Helkala E-L, Hartikainen P, Vainio P, Hallikainen M, Hänninen T, Riekkinen PJ Sr. 1995. Journal of neural transmission. 9: 73-86 A1 Journal article (refereed), original research

Interaction between genetic and environmental risk factors for Alzheimer's disease: A reanalysis of case-control studies

Van Duijn CM, Clayton DG, Chandra V, Fratiglioni L, Graves AB, Heyman A, Jorm AF, Kokmen E, Kondo K, Mortimer JA, Rocca WA, Shalat SL, Soininen H, Hofman A for the EURODEM Risk Factors Research Group. 1994. Genetic epidemiology. 11: 539-551 A1 Journal article (refereed), original research

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Keywords

Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)

Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer’s Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial

FinnGen provides genetic insights from a well-phenotyped isolated population

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Response to “Comment on ‘Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program’”

The effect of physical activity on white matter integrity in aging and prodromal to mild Alzheimer's disease with vascular comorbidity

The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

Association Between Cognition, Health Related Quality of Life, and Costs in a Population at Risk for Cognitive Decline

Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition

Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational Randomized Controlled Trial

Multimodal Preventive Trial for Alzheimer’s Disease: MIND-ADmini Pilot Trial Study Design and Progress

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial

27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

A competing risk joint model for dealing with different types of missing data in an intervention trial in prodromal Alzheimer's disease

Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

Change in CAIDE Dementia Risk Score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis

Characteristics of subjective cognitive decline associated with amyloid positivity

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease

Muistisairaudet

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study

Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.

Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Voiko kliininen ravintovalmiste jarruttaa muistisairauden etenemistä?

36-month LipiDiDiet multinutrient clinical trial in prodromal Alzheimer's disease

A structural variation reference for medical and population genetics

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus With Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia

Attitudes of at-risk older adults about prevention of cardiovascular disease and dementia using eHealth: a qualitative study in a European context.

Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

Dementia risk scores as surrogate outcomes for lifestyle-based multidomain prevention trials - rationale, preliminary evidence and challenges

Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline

Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

Earlier life leisure-time physical activity in relation to age-related frailty syndrome

Evaluating drug targets through human loss-of-function genetic variation

Experiences of dementia and attitude towards prevention: a qualitative study among older adults participating in a prevention trial

Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Late-life personality traits, cognitive impairment, and mortality in a population-based cohort

Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.

Patient-specific Alzheimer-like Pathology in Trisomy 21 Cerebral Organoids Reveals BACE2 as a Gene Dose-Sensitive AD Suppressor in Human Brain

Pooling individual participant data from randomized controlled trials: Exploring potential loss of information

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß

Production of Inflected Novel Words in Older Adults With and Without Dementia

Regional strength of large-scale functional brain networks is associated with regional volumes in older adults and in Alzheimer's disease

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

The effect of LRRK2 loss-of-function variants in humans

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The mutational constraint spectrum quantified from variation in 141,456 humans

The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study

Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol

Transcript expression-aware annotation improves rare variant interpretation

Urinary metabolic phenotyping for Alzheimer's disease

White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial

White Matter Hyperintensities are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders