Hilkka Soininen
Professor, Emerita
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 40 573 5749
Major research interests
Alzheimer’s disease and memory disorders: biomarkers, genetics, neuroimaging, therapy and prevention
Major positions and appointments
- Professor, Institute of Clinical Medicine, University of Eastern Finland, 2018 –
- Dean, Faculty of Health Sciences, University of Eastern Finland, 2012-2017
- Professor in Neurology 1989-1990,1995-1999, 2000- 2017
- Visiting Associate Professor, Southern Illinois University School of Medicine, Springfield, Illinois, 1988-1989
- Researcher, Academy of Finland, 1988-1991, 1992-1995
- Associate Professor in Neurology, Kuopio University, 1987-1988
- Lecturer, Kuopio University, 1981-1987
Research groups
-
Clinical Alzheimer Research 01.01.2022 - -
NPH and Early AD 01.01.2010 - -
UEF - Nordic-UK Brain Network (UEF-NBN) 01.01.2022 -
Projects
Publications
772/772 items-
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; Lehtisalo, Jenni; Mangialasche, Francesca; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Stephen, Ruth; Kivipelto, Miia; Solomon, Alina. 2024. Alzheimer's & dementia. 20: 4345-4350 A1 Journal article (refereed), original research -
Cognition, Depression, Pain, and Exercise Motives as Predictors of Longitudinal Profiles of Physical Activity During a Seven‐Year Follow‐Up Among Older Adults
Saila, Kyrönlahti; Jenni, Lehtisalo; Tiia, Ngandu; Miia, Kivipelto; Timo, Strandberg; Riitta, Antikainen; Tiina, Laatikainen; Hilkka, Soininen; Jaakko, Tuomilehto; Satu, Havulinna; Jenni, Kulmala. 2024. Scandinavian journal of medicine and science in sports. 34: 1-12 A1 Journal article (refereed), original research -
Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia
van Gils, Aniek M.; Tolonen, Antti; van Harten, Argonde C.; Vigneswaran, Sinthujah; Barkhof, Frederik; Visser, Leonie N. C.; Koikkalainen, Juha; Herukka, Sanna-Kaisa; Hasselbalch, Steen Gregers; Mecocci, Patrizia; Remes, Anne M.; Soininen, Hilkka; Lemstra, Afina W.; Teunissen, Charlotte E.; Jönsson, Linus; Lötjönen, Jyrki; van der Flier, Wiesje M.; Rhodius-Meester, Hanneke FM. 2024. Alzheimer's research and therapy. 16: . 256 A1 Journal article (refereed), original research -
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome
Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna. 2024. Journal of neuropathology and experimental neurology. 83: 967-978 A1 Journal article (refereed), original research -
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
García-Marín, Luis M.; Campos, Adrian I.; Diaz-Torres, Santiago; Rabinowitz, Jill A.; Ceja, Zuriel; Mitchell, Brittany L.; Grasby, Katrina L.; Thorp, Jackson G.; Agartz, Ingrid; Alhusaini, Saud; Ames, David; Amouyel, Philippe; Andreassen, Ole A.; Arfanakis, Konstantinos; Arias-Vasquez, Alejandro; Armstrong, Nicola J.; Athanasiu, Lavinia; Bastin, Mark E.; Beiser, Alexa S.; Bennett, David A.; Bis, Joshua C.; Boks, Marco P. M.; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Buitelaar, Jan . 2024. Nature genetics. 56: 2333-2344 A1 Journal article (refereed), original research -
Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
Levak, Nicholas; Lehtisalo, Jenni; Thunborg, Charlotta; Westman, Eric; Andersen, Pia; Andrieu, Sandrine; Broersen, Laus M.; Coley, Nicola; Hartmann, Tobias; Irving, Gerd Faxén; Mangialasche, Francesca; Ngandu, Tiia; Pantel, Johannes; Rosenberg, Anna; Sindi, Shireen; Soininen, Hilkka; Solomon, Alina; Wang, Rui; Kivipelto, Miia. 2024. Alzheimer's research and therapy. 16: . 147 A1 Journal article (refereed), original research -
Subjective memory complaints and the effect of a multidomain lifestyle intervention on cognition – the FINGER trial
Vaskivuo, Laura; Hokkanen, Laura; Levälahti, Esko; Hänninen, Tuomo; Antikainen, Riitta; Bäckman, Lars; Laatikainen, Tiina; Paajanen, Teemu; Stigsdotter-Neely, Anna; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2024. Journals of gerontology series b: psychological sciences and social sciences. 2025; 80: . gbae179 A1 Journal article (refereed), original research -
The effect of multidomain lifestyle intervention on health care service use and costs - secondary analyses from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): a randomised controlled trial
Sääskilahti, Maria; Kulmala, Jenni; Nurhonen, Markku; Lehtisalo, Jenni; Peltonen, Markku; Mangialasche, Francesca; Laatikainen, Tiina; Strandberg, Timo; Antikainen, Riitta; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2024. Age and ageing. 53: . afae249 A1 Journal article (refereed), original research -
X‐chromosome-wide association study for Alzheimer’s disease
Le Borgne, Julie; Gomez, Lissette; Heikkinen, Sami; Amin, Najaf; Ahmad, Shahzad; Choi, Seung Hoan; Bis, Joshua; Grenier-Boley, Benjamin; Garcia Rodriguez, Omar; Kleineidam, Luca; Young, Juan; Tripathi, Kumar Parijat; Wang, Lily; Varma, Achintya; Campos-Martin, Rafael; van der Lee, Sven; Damotte, Vincent; de Rojas, Itziar; Palmal, Sagnik; EADB; GR@ACE; DEGESCO; EADI; GERAD; DemGene; FinnGen; ADGC; CHARGE; Lipton, Richard; Reiman, Eric; McKee, Ann; De Jager, Philip; Bush, William; Small, Scott; Le. 2024. Molecular psychiatry. [Published: 04 December 2024]: 1-12 A1 Journal article (refereed), original research -
Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer’s Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial
Hendrix, Suzanne B; Soininen, H; Solomon, A; Visser, PJ; van Hees, AMJ; Counotte, DS; Nicodemus-Johnson, J; Dickson, SP; Blennow, K; Kivipelto, M; Hartmann, T; LipiDiDiet clinical study group. 2023. The Journal of prevention of Alzheimer's disease. 10: 464-470 A1 Journal article (refereed), original research -
FinnGen provides genetic insights from a well-phenotyped isolated population
Kurki, Mitja I.; Karjalainen, Juha; Palta, Priit; Sipilä, Timo P.; Kristiansson, Kati; Donner, Kati M.; Reeve, Mary P.; Laivuori, Hannele; Aavikko, Mervi; Kaunisto, Mari A.; Loukola, Anu; Lahtela, Elisa; Mattsson, Hannele; Laiho, Päivi; Della Briotta Parolo, Pietro; Lehisto, Arto A.; Kanai, Masahiro; Mars, Nina; Rämö, Joel; Kiiskinen, Tuomo; Heyne, Henrike O.; Veerapen, Kumar; Rüeger, Sina; Lemmelä, Susanna; Zhou, Wei; Ruotsalainen, Sanni; Pärn, Kalle; Hiekkalinna, Tero; Koskelainen, Sami; Paaja. 2023. Nature. 613: 508-518 A1 Journal article (refereed), original research -
Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration. 2023. JAMA network open. 6: A1 Journal article (refereed), original research -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research -
Response to “Comment on ‘Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program’”
Wimo, Anders; Handels, Ron; Antikainen, Riitta; Eriksdotter, Maria; Jönsson, Linus; Knapp, Martin; Kulmala, Jenni; Laatikainen, Tiina; Lehtisalo, Jenni; Peltonen, Markku; Sköldunger, Anders; Soininen, Hilkka; Solomon, Alina; Timo Strandberg, T; Tuomilehto, Jaakko; Ngandu, Tiia; Kivipelto, Miia. 2023. Alzheimer's & dementia. 19: 4760-4763 B1 Non-refereed journal articles -
The effect of physical activity on white matter integrity in aging and prodromal to mild Alzheimer's disease with vascular comorbidity
Konwar, Srijan; Manca, Riccardo; De Marco, Matteo; Soininen, Hilkka; Venneri, Annalena. 2023. Frontiers in aging neuroscience. 15: A1 Journal article (refereed), original research -
The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia
Rydstrom, Anders; Stephen, Ruth; Kareholt, Ingemar; Mattsson, Alexander Darin; Ngandu, Tiia; Lehtisalo, Jenni; Backman, Lars; Kemppainen, Nina; Rinne, Juha; Sindi, Shireen; Soininen, Hilkka; Vanninen, Ritva; Solomon, Alina; Mangialasche, Francesca. 2023. Gerontology. 69: 972-985 A1 Journal article (refereed), original research -
Association Between Cognition, Health Related Quality of Life, and Costs in a Population at Risk for Cognitive Decline
Janssen, Niels; Handels, Ron L.; Wimo, Anders; Antikainen, Riitta; Laatikainen, Tiina; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Evers, Silvia M.A.A.; Verhey, Frans R.J.; Ngandu, Tiia. 2022. Journal of Alzheimer's disease. 89: 623-632 A1 Journal article (refereed), original research -
Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial
Neuvonen, Elisa; Lehtisalo, Jenni; Ngandu, Tiia; Levälahti, Esko; Antikainen, Riitta; Hänninen, Tuomo; Laatikainen, Tiina; Lindström, Jaana; Paajanen, Teemu; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Solomon, Alina. 2022. Journal of clinical medicine. 11: A1 Journal article (refereed), original research -
Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program
Wimo, Anders; Handels, Ron; Antikainen, Riitta; Eriksdotter, Maria; Jönsson, Linus; Knapp, Martin; Kulmala, Jenni; Laatikainen, Tiina; Lehtisalo, Jenni; Peltonen, Markku; Sköldunger, Anders; Soininen, Hilkka; Solomon, Alina; Strandberg, Timo; Tuomilehto, Jaakko; Ngandu, Tiia; Kivipelto, Miia. 2022. Alzheimer's & dementia. [First published: 16 July 2022]: 1-10 A1 Journal article (refereed), original research -
Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial
Lehtisalo, Jenni; Rusanen, Minna; Solomon, Alina; Antikainen, Riitta; Laatikainen, Tiina; Peltonen, Markku; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2022. European heart journal. 43: 2054–2061 A1 Journal article (refereed), original research -
Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition
Wesenhagen, Kirsten E. J.; Gobom, Johan; Bos, Isabelle; Vos, Stephanie J. B.; Martinez-Lage, Pablo; Popp, Julius; Tsolaki, Magda; Vandenberghe, Rik; Freund-Levi, Yvonne; Verhey, Frans; Lovestone, Simon; Streffer, Johannes; Dobricic, Valerija; Bertram, Lars; Blennow, Kaj; Pikkarainen, Maria; Hallikainen, Merja; Kuusisto, Johanna; Laakso, Markku; Soininen, Hilkka; Scheltens, Philip; Zetterberg, Henrik; Teunissen, Charlotte E.; Visser, Pieter Jelle; Tijms, Betty M.; for the Alzheimer’s Disease Neur. 2022. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 14: A1 Journal article (refereed), original research -
Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational Randomized Controlled Trial
Coley, Nicola; Andre, Laurine; Hoevenaar-Blom, Marieke P; Ngandu, Tiia; Beishuizen, Cathrien; Barbera, Mariagnese; van Wanrooij, Lennard; Kivipelto, Miia; Soininen, Hilkka; van Gool, Willem; Brayne, Carol; Moll van Charante, Eric; Richard, Edo; Andrieu, Sandrine; HATICE study group; PRODEMOS study group. 2022. Journal of medical internet research. 24: A1 Journal article (refereed), original research -
Multimodal Preventive Trial for Alzheimer’s Disease: MIND-ADmini Pilot Trial Study Design and Progress
Sindi, S; Thunborg, C; Rosenberg, A; Andersen, P; Andrieu, S; Broersen, LM; Coley, N; Couderc, C; Duval, CZ; Faxen-Irving, G; Hagman, G; Hallikainen, M; Håkansson, K; Lehtisalo, J; Levak, N; Mangialasche, F; Pantel, J; Kekkonen, E; Rydström, A; Stigsdotter-Neely, A; Wimo, A; Ngandu, T; Soininen, H; Hartmann, T; Solomon, A; Kivipelto, M. 2022. The Journal of prevention of Alzheimer's disease. 9: 30-39 A1 Journal article (refereed), original research -
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Em. 2022. Nature genetics. 54: 412-436 A1 Journal article (refereed), original research -
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
Jansen, Willemijn J.; Janssen, Olin; Tijms, Betty M.; Vos, Stephanie J. B.; Ossenkoppele, Rik; Visser, Pieter Jelle; Aarsland, Dag; Alcolea, Daniel; Altomare, Daniele; von Arnim, Christine; Baiardi, Simone; Baldeiras, Ines; Barthel, Henryk; Bateman, Randall J.; Van Berckel, Bart; Binette, Alexa Pichet; Blennow, Kaj; Boada, Merce; Boecker, Henning; Bottlaender, Michel; den Braber, Anouk; Brooks, David J.; Van Buchem, Mark A.; Camus, Vincent; Carill, Jose Manuel; Cerman, Jiri; Chen, Kewei; Chétela. 2022. JAMA neurology. 79: 228-243 A1 Journal article (refereed), original research -
Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial
Neuvonen, Elisa; Lehtisalo, Jenni; Solomon, Alina; Antikainen, Riitta; Havulinna, Satu; Hänninen, Tuomo; Laatikainen, Tiina; Lindström, Jaana; Rautio, Nina; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia. 2022. Aging clinical and experimental research. 34: 1793-1805 A1 Journal article (refereed), original research -
27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
Sandebring-Matton, Anna; Goikolea, Julen; Björkhem, Ingemar; Paternain, Laura; Kemppainen, Nina; Laatikainen, Tiina; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Cedazo-Minguez, Angel; Solomon, Alina; Kivipelto, Miia. 2021. Alzheimer's research and therapy. 13: 56 A1 Journal article (refereed), original research -
5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus
Junkkari, A; Sintonen, H; Danner, N; Jyrkkänen, HK; Rauramaa, T; Luikku, AJ; Koivisto, AM; Roine, RP; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2021. Journal of neurology. 268: 3283-3293 A1 Journal article (refereed), original research -
A competing risk joint model for dealing with different types of missing data in an intervention trial in prodromal Alzheimer's disease
Swinkels, Sophie HN; Soininen, Hilkka; Kivipelto, Miia; Hartmann, Tobias; Rizopoulos, Dimitris. 2021. Alzheimer's research and therapy. 13: 63 A1 Journal article (refereed), original research -
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans
Gudmundsson, Sanna; Karczewski, Konrad J.; Francioli, Laurent C.; Tiao, Grace; Cummings, Beryl B.; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L.; Laricchia, Kristen M.; Ganna, Andrea; Birnbaum, Daniel P.; Gauthier, Laura D.; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A.; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M.; Seaby, Eleanor G.; Kosmicki, Jack A. et al [incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2021. Nature. 597: E3-E4 B1 Non-refereed journal articles -
Change in CAIDE Dementia Risk Score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis
Stephen, Ruth; Ngandu, Tiia; Liu, Yawu; Peltonen, Markku; Antikainen, Riitta; Kemppainen, Nina; Laatikainen, Tiina; Lötjönen, Jyrki; Rinne, Juha; Strandberg, Timo; Tuomilehto, Jaakko; Vanninen, Ritva; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2021. Journals of gerontology series a: biological sciences and medical sciences. 76: 1407-1414 A1 Journal article (refereed), original research -
Characteristics of subjective cognitive decline associated with amyloid positivity
Janssen, Olin; Jansen, Willemijn J; Vos, Stephanie JB; Boada, Merce; Parnetti, Lucilla; Gabryelewicz, Tomasz; Fladby, Tormod; Molinuevo, José Luis; Villeneuve, Sylvia; Hort, Jakub; Epelbaum, Stéphane; Lleó, Alberto; Engelborghs, Sebastiaan; van der Flier, Wiesje M; Landau, Susan; Popp, Julius; Wallin, Anders; Scheltens, Philip; Olde Rikkert, Marcel; Snyder, Peter J; et al.; Alzheimer's Disease Neuroimaging Initiative; FACEHBI study group; PREVENT-AD research group. 2021. Alzheimer's & dementia. [Epub ahead of print 8 Dec 2021]: 1-14 A1 Journal article (refereed), original research -
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; et al; [incl. Haapasalo, A; Soininen, H; Lehtisalo, J; Kivipelto, M; Kuulasmaa, T; Hiltunen, M]. 2021. Nature communications. 12: 3417 A1 Journal article (refereed), original research -
Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk
Solomon, Alina; Handels, Ron; Wimo, Anders; Antikainen, Riitta; Laatikainen, Tiina; Levälahti, Esko; Peltonen, Markku; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia. 2021. Journal of Alzheimer's disease. 82: 1461-1466 A1 Journal article (refereed), original research -
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Nabais, Marta F; Laws, Simon M; Lin, Tian; Vallerga, Costanza L; Armstrong, Nicola J; Blair, Ian P; Kwok, John B; Mather, Karen A; Mellick, George D; Sachdev, Perminder S; Wallace, Leanne; Henders, Anjali K; Zwamborn, Ramona AJ; Hop, Paul J; Lunnon, Katie; Pishva, Ehsan; Roubroeks, Janou AY; Soininen, Hilkka; Tsolaki, Magda; Mecocci, Patrizia; the Australian Imaging Biomarkers and Lifestyle study; et al. 2021. Genome biology. 22: 90 A1 Journal article (refereed), original research -
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease
Whiley, Luke; Chappell, Katie E; D'Hondt, Ellie; Lewis, Matthew R; Jiménez, Beatriz; Snowden, Stuart G; Soininen, Hilkka; Kloszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Swann, Jonathan R; Hye, Abdul; Lovestone, Simon; Legido-Quigley, Cristina; Holmes, Elaine. 2021. Alzheimer's research and therapy. 13: 20 A1 Journal article (refereed), original research -
Muistisairaudet
Lehtisalo, Jenni; Kivipelto, Miia; Ngandu, Tiia; Eskelinen, Marjo; Soininen, Hilkka. Teoksessa: Mutanen, Marja; Niinikoski, Harri; Schwab, Ursula; Uusitupa, Matti(toim.) , 2021. Ravitsemustiede (8. uud. painos). s. 461-466. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study
Dake, Manmohi D; De Marco, Matteo; Blackburn, Daniel J; Wilkinson, Iain D; Remes, Anne; Liu, Yawu; Pikkarainen, Maria; Hallikainen, Merja; Soininen, Hilkka; Venneri, Annalena. 2021. Journal of Alzheimer's disease reports. 5: 65-77 A1 Journal article (refereed), original research -
Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.
Deckers, Kay; Köhler, Sebastian; Ngandu, Tiia; Antikainen, Riitta; Laatikainen, Tiina; Soininen, Hilkka; Strandberg, Timo; Verhey, Frans; Kivipelto, Miia; Solomon, Alina. 2021. Alzheimer's & dementia. 17: 1205-1212 A1 Journal article (refereed), original research -
Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial
Rosenberg, Anna; Solomon, Alina; Soininen, Hilkka; Visser, Pieter Jelle; Blennow, Kaj; Hartmann, Tobias; Kivipelto, Miia; on behalf of the LipiDiDiet clinical study group [incl. Hallikainen, Ilona; Hallikainen, Merja; Helisalmi, Seppo; Lappalainen, Tarja; Liu, Yawu; Paajanen, Teemu]. 2021. Alzheimer's research and therapy. 13: 64 A1 Journal article (refereed), original research -
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko. 2021. Neurobiology of disease. 2022; 163: 105603 A1 Journal article (refereed), original research -
Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial
Sindi, Shireen; Solomon, Alina; Kåreholt, Ingemar; Hovatta, Iiris; Antikainen, Riitta; Hänninen, Tuomo; Levälahti, Esko; Laatikainen, Tiina; Lehtisalo, Jenni; Lindström, Jaana; Paajanen, Teemu; Peltonen, Markku; Singh Khalsa, Dharma; Wolozin, Benjamin; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Ngandu, Tiia; Kivipelto, Miia; for the FINGER Study Group. 2021. Journals of gerontology series a: biological sciences and medical sciences. 76: 491-498 A1 Journal article (refereed), original research -
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease
Simrén, Joel; Leuzy, Antoine; Karikari, Thomas K; Hye, Abdul; Benedet, Andréa Lessa; Lantero-Rodriguez, Juan; Mattsson-Carlgren, Niklas; Schöll, Michael; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; Soininen, Hilkka; Lovestone, Simon; Aarsland, Dag; Hansson, Oskar; Rosa-Neto, Pedro; Westman, Eric; Blennow, Kaj; Zetterberg, Henrik; et al; AddNeuroMed consortium. 2021. Alzheimer's & dementia. 17: 1145-1156 A1 Journal article (refereed), original research -
The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
Ngandu, Tiia; Lehtisalo, Jenni; Korkki, Saana; Solomon, Alina; Coley, Nicola; Antikainen, Riitta; Bäckman, Lars; Hänninen, Tuomo; Lindström, Jaana; Laatikainen, Tiina; Paajanen, Teemu; Havulinna, Satu; Peltonen, Markku; Neely, Anna Stigsdotter; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia. 2021. Alzheimer's & dementia. First published: 20 October 2021: 1 - 10 A1 Journal article (refereed), original research -
Voiko kliininen ravintovalmiste jarruttaa muistisairauden etenemistä?
Soininen, Hilkka. 2021. Lääkärilehti. 76: 915 D1 Article in a trade journal -
36-month LipiDiDiet multinutrient clinical trial in prodromal Alzheimer's disease
Soininen, Hilkka; Solomon, Alina; Visser, Pieter Jelle; Hendrix, Suzanne B; Blennow, Kaj; Kivipelto, Miia; Hartmann, Tobias; Hallikainen, Ilona; Hallikainen, Merja; Helisalmi, Seppo; Lappalainen, Tarja; Liu, Yawu; Paajanen, Teemu; Wahlund, Lars-Olof; Freund-Levi, Yvonne; Hagman, Göran; Hartmann, Tobias; Fassbender, Klaus; Riemenschneider, Matthias; Grimm, Marcus OW et al.. 2020. Alzheimer's & dementia. 2021; 17: 29-40 A1 Journal article (refereed), original research -
A structural variation reference for medical and population genetics
Collins, Ryan L; Brand, Harrison; Karczewski, Konrad J; Zhao, Xuefang; Alföldi, Jessica; Francioli, Laurent C; Khera, Armit V; Lowther, Chelsea; Gauthier, Laura D; Wang, Harold; Watts, Nicholas A; Solomonson, Matthew; O'Donnell-Luria, Anne; Baumann, Alexander; Munshi, Ruchi; Walker, Mark; Whelan, Christopher W; Huang, Yongqing; Brookings, Ted; Sharpe, Ted; et al.; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen. 2020. Nature. 581: 444-451 A1 Journal article (refereed), original research -
An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene
Roubroeks, Janoy AY; Smith, Adam R; Smith, Rebecca G; Pishva, Ehsan; Ibrahim, Zina; Sattlecker, Martina; Hannon, Eilis J; Kloszewska, Iwona; Mecocci, Patrizia; Soininen, Hilkka; Tsolaki, Magda; Vellas, Bruno; Wahlund, Lars-Olof; Aarsland, Dag; Proitsi, Petroula; Hodges, Angela; Lovestone, Simon; Newhouse, Stephen J; Dobson, Richard JB; Mill, Jonathan; et al.. 2020. Neurobiology of aging. 95: 26-45 A1 Journal article (refereed), original research -
Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus With Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia
Pekkala, Timo; Hall, Anette; Mangialasche, Francesca; Kemppainen, Niina; Mecocci, Patrizia; Ngandu, Tiia; Rinne, Juha O; Soininen, Hilkka; Tuomilehto, Jaakko; Kivipelto. Miia; Solomon. Alina 1 2. 2020. Journal of Alzheimer's disease. 76: 1243-1248 A1 Journal article (refereed), original research -
Attitudes of at-risk older adults about prevention of cardiovascular disease and dementia using eHealth: a qualitative study in a European context.
Akenine, Ulrika; Barbera, Mariagnese; Beishuizen, Cathrien Rl; Fallah Pour, Mandana; Guillemont, Juliette; Rosenberg, Anna; Coley, Nicola; Mangialasche, Francesca; Salo, Lotta; Savy, Stephanie; Pols, A Jeannette; Andrieu, Sandrine; Richard, Edo; Soininen, Hilkka; Moll van Charante, Eric; Kivipelto, Miia; The HATICE study group. 2020. BMJ open. 10: e037050 A1 Journal article (refereed), original research -
Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland
Liang, Yajun; Ngandu, Tiia; Laatikainen, Tiina; Soininen, Hilkka; Tuomilehto, Jaakko; Kivipelto, Miia; Qiu, Chengxuan. 2020. PLoS medicine. 17: e1003474 A1 Journal article (refereed), original research -
Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals
Whiffin, Nicola; Karczewski, Konrad J; Zhang, Xiaolei; Chothani, Sonia; Smith, Miriam J; Evans, D Gareth; Roberts, Angharad M; Quaife, Nicholas M; Schafer, Sebastian; Rackham, Owen; Alföldi, Jessica; O'Donnell-Luria, Anne H; Francioli, Laurent C; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature communications. 11: 2523 A1 Journal article (refereed), original research -
Dementia risk scores as surrogate outcomes for lifestyle-based multidomain prevention trials - rationale, preliminary evidence and challenges
Coley, N; Hoevenaar-Blom, MP; van Dalen, JW; Moll van Charante, EP; Kivipelto, M; Soininen, H; Andrieu, S; Richard, E. 2020. Alzheimer's & dementia. 16: 1674-1685 A1 Journal article (refereed), original research -
Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline
Pekkala, Timo; Hall, Anette; Ngandu, Tiia; Gils, Mark van; Helisalmi, Seppo; Hänninen, Tuomo; Kemppainen, Nina; Liu, Yawu; Lötjönen, Jyrki; Paajanen, Teemu; Rinne, Juha O; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2020. Frontiers in aging neuroscience. 12: 228 A1 Journal article (refereed), original research -
Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members
Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Fluids and barriers of the cns. 17: 57 A1 Journal article (refereed), original research -
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
Shi, L; Winchester, LM; Liu, BY; Killick, R; Ribe, EM; Westwood, S; Baird, AL; Buckley, NJ; Hong, S; Dobricic, V; Kilpert, F; Franke, A; Kiddle, S; Sattlecker, M; Dobson, R; Cuadrado, A; Hye, A; Ashton, NJ; Morgan, AR; Bos, I; et al. [incl. Soininen, H]. 2020. Journal of Alzheimer's disease. 77: 1353-1368 A1 Journal article (refereed), original research -
Earlier life leisure-time physical activity in relation to age-related frailty syndrome
Kolehmainen, L; Havulinna, S; Ngandu, T; Strandberg, T; Levälahti, E; Lehtisalo, J; Antikainen, R; Hietikko, E; Peltonen, M; Pölönen, A; Soininen, H; Tuomilehto, J; Laatikainen, T; Rauramaa, R; Kivipelto, M; Kulmala, J. 2020. Age and ageing. 2021; 50: 161-168 A1 Journal article (refereed), original research -
Evaluating drug targets through human loss-of-function genetic variation
Minikel, Eric Vallabh; Karczewski, Konrad J; Martin, Hilary C; Cummings, Beryl B; Whiffin, Nicola; Rhodes, Daniel; Alföldi, Jessica; Trembath, Richard C; van Heel, David A; Daly, Mark J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Schreiber, Stuart L; MacArthur, Daniel G [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature. 581: 459-464 A1 Journal article (refereed), original research -
Experiences of dementia and attitude towards prevention: a qualitative study among older adults participating in a prevention trial
Rosenberg, Anna; Coley, Nicola; Soulier, Alexandra; Kulmala, Jenni; Soininen, Hilkka; Andrieu, Sandrine; Kivipelto, Miia; Barbera, Mariagnese; for the MIND-AD and HATICE groups. 2020. Bmc geriatrics. 20: 99 A1 Journal article (refereed), original research -
Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort
Muurling, Marijn; Rhodius-Meester, Hanneke; Pärkkä, Juha; van Gils, Mark; Frederiksen, Kristian S; Bruun, Marie; Hasselbalch, Steen G; Soininen, Hilkka; Herukka, Sanna-Kaisa; Hallikainen, Merja; Teunissen, Charlotte E; Visser, Pieter; Scheltens, Philip; van der Flier, Wiesje M; Mattila, Jussi; Lötjönen, Jyrki; de Boer, Casper. 2020. Journal of Alzheimer's disease. 76: 1061-1070 A1 Journal article (refereed), original research -
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
Wang, Qingbo; Pierce-Hoffman, Emma; Cumings, Beryl B; Alföldi, Jessica; Francioli, Laurent C; Gauthier, Laura D; Hill, Andrew J; O'Donnell-Luria, Anne H; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature communications. 11: 2539 A1 Journal article (refereed), original research -
Late-life personality traits, cognitive impairment, and mortality in a population-based cohort
Neuvonen, Elisa; Hall, Anette; Tolppanen, Anna-Maija; Ngandu, Tiia; Rusanen, Minna; Laatikainen, Tiina; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2020. International journal of geriatric psychiatry. 35: 989-999 A1 Journal article (refereed), original research -
Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.
Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Journal of Alzheimer's disease. 74: 277-286 A1 Journal article (refereed), original research -
Patient-specific Alzheimer-like Pathology in Trisomy 21 Cerebral Organoids Reveals BACE2 as a Gene Dose-Sensitive AD Suppressor in Human Brain
Alic, I; Goh, PA; Murray, A; Portelius, E; Gkanatsiou, E; Gough, G; Mok, KY; Koschut, D; Brunmeir, R; Yeap, YJ; O'Brien, NL; Groet, J; Shao, X; Havlicek, S; Dunn, NR; Kvartsberg, H; Brinkmalm, G; Hithersay, R; Startin, C; Hamburg, S; et al. [incl. Soininen, H]. 2020. Molecular psychiatry. 2021; 26: 5766-5788 A1 Journal article (refereed), original research -
Pooling individual participant data from randomized controlled trials: Exploring potential loss of information
van Wanrooij, Lennard L; Hoevenaar-Blom, Marieke P; Coley, Nicola; Ngandu, Tiia; Meiller, Yannick; Guillemont, Juliette; Rosenberg, Anna; Beishuizen, Cathrien R L; Moll van Charante, Eric P; Soininen, Hilkka; Brayne, Carol; Andrieu, Sandrine; Kivipelto, Miia; Richard, Edo. 2020. PLoS ONE. 15: e0232970 A1 Journal article (refereed), original research -
Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß
Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Cells. 9: 2482 A1 Journal article (refereed), original research -
Production of Inflected Novel Words in Older Adults With and Without Dementia
Nikolaev, Alexandre; Higby, Eve; Hyun, JungMoon; Lehtonen, Minna; Ashaie, Sameer; Hallikainen, Merja; Hänninen, Tuomo; Soininen, Hilkka. 2020. Cognitive science. 44: e12879 A1 Journal article (refereed), original research -
Regional strength of large-scale functional brain networks is associated with regional volumes in older adults and in Alzheimer's disease
Sarli, Giuseppe; De Marco, Matteo; Hallikainen, Merja; Soininen, Hilkka; Bruno, Giuseppe; Venneri, Annalena. 2020. Brain connectivity. 2021; 11: 201-212 A1 Journal article (refereed), original research -
Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy
Rhodius-Meester, HFM; van Maurik, IS; Koikkalainen, J; Tolonen, A; Frederiksen, KS; Hasselbalch, SG; Soininen, H; Herukka, SK; Remes, AM; Teunissen, CE; Barkhof, F; Pijnenburg, YAL; Scheltens, P; Lötjönen, J; van der Flier, WM. 2020. PLoS ONE. 15: e0226784 A1 Journal article (refereed), original research -
The effect of LRRK2 loss-of-function variants in humans
Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco AS; Merchant, Kalpana M; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; et al.[Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature medicine. 26: 869-877 A1 Journal article (refereed), original research -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Elvsåshagen, T; Bahrami, S; van der Meer, D; Alnæs, D; Frei, O; Jönsson, EG; Lagerberg, TV; Maglanoc, LA; Melle, I; Moberget, T; O'Connell, KS; Rokicki, J; Shadrin, AA; Andreassen, OA; Westlye, LT; Kaufmann, T; Celius, EG; Harbo, HF; Høgestøl, EA; Beyer, MK (incl. Soininen, H). 2020. Nature communications. : 4016 (2020) A1 Journal article (refereed), original research -
The mutational constraint spectrum quantified from variation in 141,456 humans
Karczewski, Konrad J; Francioli, Laurent C; Tiao, Grace; Cummings, Beryl B; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L; Laricchia, Kristen M; Ganna, Andre; Birnbaum, Daniel P; Gauthier, Laura D; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M; Seaby, Eleanor G; Kosmicki, Jack A; Walters, Raymond K; et al.; Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature. 581: 434-443 A1 Journal article (refereed), original research -
The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study
Mårtensson, Gustav; Ferreira, Daniel; Granberg, Tobias; Cavallin, Lena; Oppedal, Ketil; Padovani, Alessandro; Rektorova, Irena; Bonanni, Laura; Pardini, Matteo; Kramberger, Milica G; Taylor, John-Paul; Hort, Jakub; Snædal, Jón; Kulisevsky, Jaime; Blanc, Frederic; Antonini, Angelo; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; et al. [incl. Soininen, Hilkka]. 2020. Medical image analysis. 66: 101714 A1 Journal article (refereed), original research -
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol
Barbera, Mariagnese; Kulmala, Jenni; Lisko, Inna; Pietilä, Eija; Rosenberg, Anna; Hallikainen, Ilona; Hallikainen, Merja; Laatikainen, Tiina; Lehtisalo, Jenni; Neuvonen, Elisa; Rusanen, Minna; Soininen, Hilkka; Tuomilehto, Jaakko; Ngandu, Tiia; Solomon, Alina; Kivipelto, Miia. 2020. Bmc geriatrics. 20: 238 A1 Journal article (refereed), original research -
Transcript expression-aware annotation improves rare variant interpretation
Cummings, Beryl B; Karczewski, Konrad J; Kosmicki, Jack A; Seaby, Eleanor G; Watts, Nicholas A; Singer-Berk, Moriel; Mudge, Jonathan M; Karjalainen, Juha; Satterstrom, F Kyle; O'Donnell-Luria, Anne H; Poterba, Timothy; Seed, Cotton; Solomonson, Matthew; Alföldi, Jessica; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Daly, Mark J; MacArthur, Daniel G; et al. [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Nature. 581: 452-458 A1 Journal article (refereed), original research -
Urinary metabolic phenotyping for Alzheimer's disease
Kurbatova, Natalja; Garg, Manik; Whiley, Luke; Chekmeneva, Elena; Jiménez, Beatriz; Gómez-Romero, María; Pearce, Jake; Kimhofer, Torben; D'Hondt, Ellie; Soininen, Hilkka; Kloszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Aarsland, Dag; Nevado-Holgado, Alejo; et al.. 2020. Scientific reports. 10: 21745 A1 Journal article (refereed), original research -
White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial
Stephen, Ruth; Solomon, Alina; Ngandu, Tiia; Levälahti, Esko; Rinne, Juha O; Kemppainen, Nina; Parkkola, Riitta; Antikainen, Riitta; Strandberg, Timo; Kivipelto, Miia; Soininen, Hilkka; Liu, Yawu. 2020. Journal of Alzheimer's disease. 78: 75-86 A1 Journal article (refereed), original research -
White Matter Hyperintensities are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers
van Waalwijk van Doorn, Linda J C; Ghafoorian, Mohsen; van Leijsen, Esther M C; Claassen, Jurgen A H R; Arighi, Andrea; Bozzali, Marco; Cannas, Jorge; Cavedo, Enrica; Eusebi, Paolo; Farotti, Lucia; Fenoglio, Chiara; Fortea, Juan; Frisoni, Giovanni B; Galimberti, Daniela; Greco, Viviana; Herukka, Sanna-Kaisa; Liu, Yawu; Lleó, Alberto; de Mendonça, Alexandre; Nobili, Flavio M; et al. [incl. Pikkarainen, Maria; Soininen, Hilkka]. 2020. Journal of Alzheimer's disease. 2021; 79: 163-175 A1 Journal article (refereed), original research -
World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
Kivipelto, M; Mangialasche, F; Snyder, HM; Allegri, R; Andrieu, S; Arai, H; Baker, L; Belleville, S; Brodaty, H; Brucki, SM; Calandri, I; Caramelli, P; Chen, C; Chertkow, H; Chew, E; Choi, SH; Chowdhary, N; Crivelli, L; De La Torre, R; Du, Y; et al. [Incl. Lehtisalo, J; Rosenberg, A; Soininen, H; Solomon, A]. 2020. Alzheimer's & dementia. 16: 1078-1094 A1 Journal article (refereed), original research -
cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders
Rhodius-Meester, HFM; Paajanen, T; Koikkalainen, J; Mahdiani, S; Bruun, M; Baroni, M; Lemstra, AW; Scheltens, P; Herukka, SK; Pikkarainen, M; Hall, A; Hänninen, T; Ngandu, T; Kivipelto, M; van Gils, M; Hasselbalch, SG; Mecocci, P; Remes, A; Soininen, H; van der Flier, WM; Lötjönen, J. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 12: e12083 A1 Journal article (refereed), original research -
Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials
Coley, N; Ngandu, T; Lehtisalo, J; Soininen, H; Vellas, B; Richard, E; Kivipelto, M; Andrieu, S; HATICE, FINGER, MAPT/DSA groups. 2019. Alzheimer's & dementia. 15: 729-741 A1 Journal article (refereed), original research -
Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in alzheimer's disease
Jones, Sarah Amy; De Marco, Matteo; Manca, Riccardo; Bell, Simon M; Blackburn, Daniel J; Wilkinson, Iain D; Soininen, Hilkka; Venneri, Annalena. 2019. Cortex. 119: 100-110 A1 Journal article (refereed), original research -
Alzheimer's Disease Composite Score: A Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer's Disease
Hendrix, Suzanne B; Soininen, H; van Hees, AMJ; Ellison, N; Visser, PJ; Solomon, A; Attali, A; Blennow, K; Kivipelto, M; Hartmann, T. 2019. The Journal of prevention of Alzheimer's disease. 6: 232-236 A1 Journal article (refereed), original research -
Automatically computed rating scales from MRI for patients with cognitive disorders
Koikkalainen, JR; Rhodius-Meester, HFM; Frederiksen, KS; Bruun, M; Hasselbalch, SG; Baroni, M; Mecocci, P; Vanninen, R; Remes, A; Soininen, H; van Gils, M; van der Flier, WM; Scheltens, P; Barkhof, F; Erkinjuntti, T; Lötjönen, JMP. 2019. European radiology. 29: 4937-4947 A1 Journal article (refereed), original research -
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study
van Maurik, IS; Vos, SJ; Bos, I; Bouwman, FH; Teunissen, CE; Scheltens, P; Barkhof, F; Frolich, L; Kornhuber; J; Wiltfang, J; Maier, W; Peters, O; Rüther, E; Nobili, F; Frisoni, GB; Spiru, L; Freund-Levi, Y; Wallin, AK; Hampel, H; Soininen, H; Tsolaki, M; et al. (incl. Herukka, SK). 2019. The Lancet Neurology. 18: 1034-1044 A1 Journal article (refereed), original research -
Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
Stephen, R; Liu, Y; Ngandu, T; Antikainen, R; Hulkkonen, J; Koikkalainen, J; Kemppainen, N; Lötjönen, J; Levälahti, E; Parkkola, R; Pippola, P; Rinne, J; Strandberg, T; Tuomilehto, J; Vanninen, R; Kivipelto, M; Soininen, H; Solomon, A. 2019. Alzheimer's research and therapy. 11: 53 A1 Journal article (refereed), original research -
Cardiorespiratory Fitness and Cognition: Longitudinal Associations in the FINGER Study
Pentikäinen, H; Savonen, K; Ngandu, T; Solomon, A; Komulainen, P; Paajanen, T; Antikainen, R; Kivipelto, M; Soininen, H; Rauramaa, R. 2019. Journal of Alzheimer's disease. 68: 961-968 A1 Journal article (refereed), original research -
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann, T; van der Meer, D; Doan, NT Schwarz, E; Lund, MJ; Agartz, I; Alnæs, D; Barch, DM; Baur-Streubel, R; Bertolino, A; Bettella, F; Beyer, MK; Bøen, E; Borgwardt, S; Brandt, CL; Buitelaar, J; Celius, EGl; Cervenka, S; Conzelmann, A; Córdova-Palomera, A; et al. (incl. Soininen, H). 2019. Nature neuroscience. 22: 1617-1623 A1 Journal article (refereed), original research -
Computer-based cognitive training for older adults: Determinants of adherence
Turunen, Merita; Hokkanen, Lauta; Bäckman, Lars; Stigsdotter-Neely, Anna; Hänninen, Tuomo; Paajanen, Teemu; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2019. PLoS ONE. 14: e0219541 A1 Journal article (refereed), original research -
Detecting frontotemporal dementia syndromes using MRI biomarkers
Bruun, M; Koikkalainen, J; Rhodius-Meester, HFM; Baroni, M; Gjerum, L; van Gils, M; Soininen, H; Remes, AM; Hartikainen, P; Waldemar, G; Mecocci, P; Barkhof, F; Pijnenburg, Y; van der Flier, WM; Hasselbalch, SG; Lötjönen, J; Frederiksen, KS. 2019. Neuroimage : clinical. 22: 101711 A1 Journal article (refereed), original research -
Dietary changes and cognition over 2 years within a multidomain intervention trial - The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
Lehtisalo, J; Levälahti, E; Lindström, J; Hänninen, T; Paajanen, T; Peltonen, M; Antikainen, R; Laatikainen, T; Strandberg, T; Soininen, H; Tuomilehto, J; Kivipelto, M; Ngandu, T. 2019. Alzheimer's & dementia. 15: 410-417 A1 Journal article (refereed), original research -
Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease
Boccardi, V; Westman, E; Pelini, L; Lindberg, O; Muehlboeck, JS; Simmons, A; Tarducci, R; Floridi, P; Chiarini, P; Soininen, H; Kloszewska, I; Tsolaki, M; Vellas, B; Spenger, C; Wahlund, LO; Lovestone, S; Mecocci, P. 2019. Frontiers in aging neuroscience. 10: 439 A1 Journal article (refereed), original research -
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
Vermunt, L; Sikkes, SAM; van den Hout, A; Handels, R; Bos, I; van der Flier, WM; Kern, S; Ousset, PJ; Maruff, P; Skoog, I; Verhey, FRJ; Freund-Levi, Y; Tsolaki, M; Wallin, ÅK; Olde Rikkert, M; Soininen, H; Spiru, L; Zetterberg, H; Blennow, K; Scheltens, P; et al.. 2019. Alzheimer's & dementia. 15: 888-898 A1 Journal article (refereed), original research -
Effects of morphological family on word recognition in normal aging, mild cognitive impairment, and Alzheimer's disease
Nikolaev, Alexandre; Ashaie, Sameer; Hallikainen, Merja; Hänninen, Tuomo; Higby, Eve; Hyun, JungMoon; Lehtonen, Minna; Soininen, Hilkka. 2019. Cortex. 116: 91-103 A1 Journal article (refereed), original research -
FINGER-elintapaohjelma -toimintamalli kognitiivisen toimintakyvyn tukemiseen
Kivipelto, Miia; Kulmala, Jenni; Lehtisalo, Jenni; Solomon, Alina; Lindström, Jaana; Rauramaa, Rainer; Peltonen, Markku; Laatikainen, Tiina; Havulinna, Satu; Soininen, Hilkka; Tuomilehto, Jaakko; Hänninen, Tuomo; Paajanen, Teemu; Antikainen, Riitta; Strandberg, Timo; Ngandu, Tiia. 2019. Lääkärilehti. 74: 183-186 D1 Article in a trade journal -
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti; Soininen, Hilkka; Kälviäinen, Reetta). 2019. Nature communications. 10: 4329 A1 Journal article (refereed), original research -
Genetic architecture of subcortical brain structures in 38,851 individuals
Satizabal, CL; Adams, HHH; Hibar, DP; White, CC; Knol, MJ; Stein, JL; Scholz, M; Sargurupremraj, M; Jahanshad, N; Roshchupkin, GV; Smith, AV; Bis, JC; Jian, X; Luciano, M; Hofer, E; Teumer, A; van der Lee, SJ; Yang, J; Yanek, LR; Lee, TV; et al. incl. Soininen, H. 2019. Nature genetics. 51: 1624-1636 A1 Journal article (refereed), original research -
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing
Kunkle, BW; Grenier-Boley, B; Sims, R; Bis, JC; Damotte, V; Naj, AC; Boland, A; Vronskaya, M; van der Lee, S; Amlie-Wolf, A; Bellenguez, C; Frizatti, A; Chouraki, V; Martin, ER; Sleegers, K; Badarinarayan, N; Jakobsdottir, J; Hamilton-Nelson, KL; Moreno-Grau, S; Olaso R; et al. (Incl. Hiltunen, Mikko; Haapasalo; Annakaisa; Helisalmi, Seppo; Koivisto, Anne; Soininen, Hilkka). 2019. Nature genetics. 51: 414-430 A1 Journal article (refereed), original research -
Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial
Richard, Edo; van Charante, Eric P Moll; Hoevenaar-Blom, Marieke P; Coley, Nicola, Barbera, Mariagnese; van der Groep, Abraham; Meiller, Yannick; Mangialasche, Francesca; Beishuizen, Cathrien B; Jongstra, Susan; van Middelaar, Tessa; Van Wanrooij, Lennard L; Ngandu, Tiia; Guillemont, Juliette; Andrieu, Sandrine; Brayne, Carol; Kivipelto, Miia; Soininen, Hilkka; Van Gool, Willem A. 2019. The Lancet : digital health. 1: e424-e434 A1 Journal article (refereed), original research -
Impact of a clinical decision support tool on dementia diagnostics in memory clinics: The PredictND validation study
Bruun, M; Frederiksen, KS; Rhodius-Meester, HFM; Baroni, M; Gjerum, L; Koikkalainen, J; Urhema, T; Tolonen, A; van Gils, M; Tong, T; Rueckert, D; Dyremos, N; Bo Andersen, B; Simonsen, AH; Lemstra, A; Hallikainen, M; Kurl, S; Herukka, SK; Remes, AM; Waldemar, G; et al. (incl. Soininen, Hilkka). 2019. Current alzheimer research. 16: 91-101 A1 Journal article (refereed), original research -
Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study
Bruun, M; Frederiksen, KS; Rhodius-Meester, HFM; Baroni, M; Gjerum, L; Koikkalainen, J; Urhemaa, T; Tolonen, A; van Gils, M; Rueckert, D; Dyremose, N; Andersen, BB; Lemstra, AW; Hallikainen, M; Kurl, S; Herukka, SK; Remes, AM; Waldemar, G; Soininen, H; Mecocci, P; et al. 2019. Alzheimer's research and therapy. 11: 25 A1 Journal article (refereed), original research -
Inflammatory biomarkers in Alzheimer's disease plasma
Morgan, AR; Touchard, S; Leckey, C; O'Hagan, C; Nevado-Holgado, AJ; Barkhof, F; Bertram, L; Blin, O; Bos, I; Dobricic, V; Engelborghs, S; Frisoni, G; Frölich, L; Gabel, S; Johannsen, P; Kettunen, P; Kloszewska, I; Legido-Quigley, C; Lleó, A; et al. (incl. Soininen, H). 2019. Alzheimer's & dementia. 15: 776-787 A1 Journal article (refereed), original research -
Integrating nurses' experiences with supporting behaviour change for cardiovascular prevention into a self-management internet platform in Finland and the Netherlands: a qualitative study
Beishuizen, CR; Akenine, U; Barbera, M; Rosenberg, A; Fallah Pour, M; Richard, E; Soininen, H; Mangialasche, F; Kivipelto, M; Pols, AJ; Moll van Charante, E. 2019. BMJ open. 9: e023480 A1 Journal article (refereed), original research -
Long-term dementia risk prediction by the LIBRA score: a 30-year follow-up of the CAIDE study
Deckers, K; Barbera, M; Köhler, S; Ngandu, T; van Boxtel, M; Rusanen, M; Laatikainen, T; Verhey, F; Soininen, H; Kivipelto, M; Solomon, A. 2019. International journal of geriatric psychiatry. 2020; 35: 195-203 A1 Journal article (refereed), original research -
Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients
Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease. 72: 127-137 A1 Journal article (refereed), original research -
Midlife improvements in financial situation are associated with a reduced dementia risk later in life: The CAIDE 30-Year Study
Sindi, S; Darin-Mattsson, A; Kåreholt, I; Kulmala, J; Ngandu, T; Laatikainen, T; Soininen, H; Kivipelto, M. 2019. International psychogeriatrics. [Published online 25 November 2019]: 1-8 A1 Journal article (refereed), original research -
Muistiterveys
Soininen, Hilkka. Teoksessa: Pietilä, Anna-Maija; Terkamo-Moisio, Anja(toim.) , 2019. Näkökulmia terveyteen ja sen edistämiseen. s. 167-176. Itä-Suomen yliopisto B2 Book section -
Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison
Coley, N; Rosenberg, A; van Middelaar, T; Soulier, A; Barbera, M; Guillemont, J; Steensma, J; Igier, V; Eskelinen, M; Soininen, H; Moll van Charante, E; Richard, E; Kivipelto, M; Andrieu, S. 2019. Journal of the american medical directors association. 20: 843-849.e5 A1 Journal article (refereed), original research -
Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus
Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease. 71: 1233-1243 A1 Journal article (refereed), original research -
Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study
Hall, A; Pekkala, T; Polvikoski, T; van Gils, M; Kivipelto, M; Lötjönen, J; Mattila, J; Kero, M; Myllykangas, L; Mäkelä, M; Oinas, M; Paetau, A; Soininen, H; Tanskanen, M; Solomon, A. 2019. Alzheimer's research and therapy. 11: 11 A1 Journal article (refereed), original research -
Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus
Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Dementia and geriatric cognitive disorders. 47: 91-103 A1 Journal article (refereed), original research -
Self and Informant Memory Reports in FINGER: Associations with Two-Year Cognitive Change
Vaskivuo, L; Hokkanen, L; Hänninen, T; Antikainen, R; Bäckman, L; Laatikainen, T; Paajanen, T; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Soininen, H; Kivipelto, M; Ngandu, T. 2019. Journal of Alzheimer's disease. 71: 785-795 A1 Journal article (refereed), original research -
Serum insulin and cognitive performance in older adults: a longitudinal study
Hooshmand, B; Rusanen, M; Ngandu, T; Leiviskä, J; Sindi, S; von Arnim, CAF; Falkai, P; Soininen, H; Tuomilehto, J; Kivipelto, M. 2019. American journal of medicine. 132: 367-373 A1 Journal article (refereed), original research -
The Association Between Distinct Frontal Brain Volumes and Behavioral Symptoms in Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia
Cajanus, A; Solje, E; Koikkalainen, J; Lötjönen, J; Suhonen, NM; Hallikainen, I; Vanninen, R; Hartikainen, P; de Marco, M; Venneri, A; Soininen, H; Remes, AM; Hall, A. 2019. Frontiers in neurology. 10: 1059 A1 Journal article (refereed), original research -
The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People
Kulmala, J; Ngandu, T; Havulinna, S; Levälahti, E; Lehtisalo, J; Solomon, A; Antikainen, R; Laatikainen, T; Pippola, P; Peltonen, M; Rauramaa, R; Soininen, H; Strandberg, T; Tuomilehto, J; Kivipelto, M. 2019. Journal of the american geriatrics society. 67: 1138-1144 A1 Journal article (refereed), original research -
Understanding the effect of cognitive/brain reserve and depression on regional atrophy in early Alzheimer's disease
Capogna, E; Manca, R; De Marco, M; Hall, A; Soininen, H; Venneri, A. 2019. Postgraduate medicine. 131: 533-538 A1 Journal article (refereed), original research -
Using joint models to disentangle intervention effect types and baseline confounding: an application within an intervention study in prodromal Alzheimer's disease with Fortasyn Connect
van Oudenhoven, FM; Swinkels, SHN; Hartmann, T; Soininen, H; van Hees, AMJ; Rizopoulos, D. 2019. Bmc medical research methodology. 19: 163 A1 Journal article (refereed), original research -
[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus
Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. Journal of Alzheimer's disease. 67: 1343-1351 A1 Journal article (refereed), original research -
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
Marttinen, M; Paananen, J; Neme, A; Mitra, V; Takalo, M; Natunen, T; Paldanius, KMA; Mäkinen, P; Bremang, M; Kurki, MI; Rauramaa, T; Leinonen, V; Soininen, H; Haapasalo, A; Pike, I; Hiltunen, M. 2018. Neurobiology of disease. 2019; 124: 454-468 A1 Journal article (refereed), original research -
Alzheimerin taudin haaste - patofysiologiasta hoidon tutkimukseen
Soininen, Hilkka. 2018. Duodecim. 134: 2509-2510 D1 Article in a trade journal -
Associations between Prospective and Retrospective Subjective Memory Complaints and Neuropsychological Performance in Older Adults: The Finger Study
Vaskivuo, Laura; Hokkanen, Laura; Hänninen, Tuomo; Antikainen, Riita; Bäckman, Lars; Laatikainen, Tiina; Paajanen, Teemu; Stigsdotter-Neely, Anna; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2018. Journal of the international neuropsychological society. 24: 1099-1109 A1 Journal article (refereed), original research -
Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis
Cajanus, A; Hall, A; Koikkalainen, J; Solje, E; Tolonen, A; Urhemaa, T; Liu, Y; Haanpää, RM; Hartikainen, P; Helisalmi, S; Korhonen, V; Rueckert, D; Hasselbalch, S; Waldemar, G; Mecocci, P; Vanninen, R; van Gils, M; Soininen, H; Lötjönen, J; Remes, AM. 2018. Dementia and geriatric cognitive disorders extra. 8: 51-59 A1 Journal article (refereed), original research -
Brain ß-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
Martikainen, IK; Kemppainen, N; Johansson, J; Teuho, J; Helin, S; Liu, Y; Helisalmi, S; Soininen, H; Parkkola, R; Ngandu, T; Kivipelto, M; Rinne, JO. 2018. American journal of neuroradiology. 2019; 40: 80-85 A1 Journal article (refereed), original research -
Cardiorespiratory fitness and risk of dementia: a prospective population-based cohort study
Kurl, S; Laukkanen, J A; Lönnroos, E; Remes, A M; Soininen, H. 2018. Age and ageing. 47: 611-614 A1 Journal article (refereed), original research -
Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH
Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Neurology : Genetics. 4: e291 A1 Journal article (refereed), original research -
Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier
Tolonen, Antti; Rhodius-Meester, Hanneke FM; Bruun, Marie; Koikkalainen, Juha; Barkhof, Frederik; Lemstra, Afina W; Koene, Teddy; Scheltens, Philip; Teunissen, Charlotte E; Tong, Tong; Guerrero, Ricardo; Schuh, Andreas; Ledig, Christian; Baroni, Marta; Rueckert, Daniel; Soininen, Hilkka; Remes, Anne M; Waldemar, Gunhild; Hasselbalch, Steen G; Mecocci, Patrizia; et al.. 2018. Frontiers in aging neuroscience. 10: 111 A1 Journal article (refereed), original research -
Decreased plasma C-reactive protein levels in APOE E 4 allele carriers
Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Annals of clinical and translational neurology. 5: 1229-1240 A1 Journal article (refereed), original research -
Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial
Solomon, A; Turunen, H; Ngandu, T; Peltonen, M; Levälahti, E; Helisalmi, S; Antikainen, R; Bäckman, L; Hänninen, T; Jula, A; Laatikainen, T; Lehtisalo, J; Lindström, J; Paajanen, T; Pajala, S; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Soininen, H; Kivipelto, M. 2018. JAMA neurology. 75: 462-470 A1 Journal article (refereed), original research -
Epilepsy in neuropathologically verified Alzheimer's disease
Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Seizure: european journal of epilepsy. 58: 9-12 A1 Journal article (refereed), original research -
Evaluating combinations of diagnostic tests to discriminate different dementia types
Bruun, Marie; Rhodius-Meester, Hanneke FM; Koikkalainen, Juha; Baroni, Marta; Gjerum, Le; Lemstra, Afina W; Barkhof, Frederik; Remes, Anne M; Urhemaa, Timo; Tolonen, Antti; Rueckert, Daniel; van Gils, Mark; Frederiksen, Kristian S; Waldemar, Gunhild; Scheltens, Philip; Mecocci, Patrizia; Soininen, Hilkka; Lötjönen, Jyrki; Hasselbalch, Steen G; van der Flier, Wiesje M. 2018. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 10: 509-518 A1 Journal article (refereed), original research -
Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life
Sindi, Shireen; Kåreholt, Ingemar; Eskelinen, Marjo; Hooshmand, Babak; Lehtisalo, Jenni; Soininen, Hilkka; Ngandu, Tiia; Kivipelto, Miia. 2018. Nutrients. 10: 1649 A1 Journal article (refereed), original research -
Heterogeneous patterns of brain atrophy in Alzheimer's disease
Poulakis, Konstantinos; Pereira, Joana B; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; Soininen, Hilkka; Lovestone, Simon; Simmons, Andrew; Wahlund, Lars-Olof; Westman, Eric. 2018. Neurobiology of aging. 65: 98-108 A1 Journal article (refereed), original research -
Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus
Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. World neurosurgery. 112: e624-e631 A1 Journal article (refereed), original research -
Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples
Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Journal of Alzheimer's disease. 62: 269-278 A1 Journal article (refereed), original research -
Melatonin receptor type 1A gene linked to Alzheimer's disease in old age
Sulkava, S; Muggalla, P; Sulkava, R; Ollila, HM; Peuralinna, T; Myllykangas, L; Kaivola, K; Stone, DJ; Traynor, BJ; Renton, AE; Rivera, AM; Helisalmi, S; Soininen, H; Polvikoski , T; Hiltunen, M; Tienari, PJ; Huttunen, HJ; Paunio, T. 2018. Sleep. 41: 1-10 A1 Journal article (refereed), original research -
Muistiystävällisiä tutkimustekoja
Soininen, Hilkka. 2018. MUISTI. 31: 5 E1 Popularised article, newspaper article -
Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
Rosenberg, A; Ngandu, T; Rusanen, M; Antikainen, R; Bäckman, L; Havulinna, S; Hänninen, T; Laatikainen, T; Lehtisalo, J; Levälahti, E; Lindström, J; Paajanen, T; Peltonen, M; Soininen, H; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Solomon, A; Kivipelto, M. 2018. Alzheimer's & dementia. 14: 263-270 A1 Journal article (refereed), original research -
Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus
Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Neurosurgery. 2019; 84: 883-889 A1 Journal article (refereed), original research -
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers
de Matos, MR; Ferreira, C; Herukka, SK; Soininen, H; Janeiro, A; Santana, I; Baldeiras, I; Almeida, MR; Lleó, A; Dols-Icardo, O; Alcolea, D; Benussi, L; Binetti, G; Paterlini, A; Ghidoni, R; Nacmias, B; Meulenbroek, O; van Waalwijk van Doorn, LJC; Kuiperij, HB; Hausner, L; et al. 2018. Journal of Alzheimer's disease. 66: 639-652 A1 Journal article (refereed), original research -
Sleep disturbances and dementia risk: A multicenter study
Sindi, S; Kåreholt, I; Johansson, L; Skoog, J; Sjöberg, L; Wang, HX; Johansson, B; Fratiglioni, L; Soininen, H; Solomon, A; Skoog, I; Kivipelto, M. 2018. Alzheimer's & dementia. 14: 1235-1242 A1 Journal article (refereed), original research -
Sleep disturbances and later cognitive status: a multi-centre study
Sindi, S; Johansson, L; Skoog, J; Mattsson, AD; Sjöberg, L; Wang, HX; Fratiglioni, L; Kulmala, J; Soininen, H; Solomon, A; Johansson, B; Skoog, I; Kivipelto, M; Kåreholt, I. 2018. Sleep medicine. 52: 26-33 A1 Journal article (refereed), original research -
Stability of graph theoretical measures in structural brain networks in Alzheimer's disease
Martensson, Gustav; Pereira, Joana B; Mecocci, Patrizia; Vellas, Bruno; Tsolaki, Magda; Kloszewska, Iwona; Soininen, Hilkka; Lovestone, Simon; Simmons, Andrew; Volpe, Giovanni; Westman, Eric. 2018. Scientific reports. 8: 11592 A1 Journal article (refereed), original research -
Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject
Haapalinna, F; Kokki, M; Jääskeläinen, O; Hallikainen, M; Helisalmi, S; Koivisto, A; Kokki, H; Paajanen, T; Penttinen, J; Pikkarainen, M; Rautiainen, M; Soininen, H; Solje, E; Remes, AM; Herukka, SK. 2018. Journal of Alzheimer's disease. 62: 165-174 A1 Journal article (refereed), original research -
Suomeen perustetaan kansallinen neurokeskus: Perustutkimuksen innovaatiot kliiniseen testaukseen ja käyttöön [Pääkirjoitus]
von und zu Fraunberg, Mikael; Jaronen, Merja; Soininen, Hilkka. 2018. Duodecim. 134: 1661-1662 D1 Article in a trade journal -
Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor
Ore¨ic, M; Anderson, G; Mattila, I; Manoucheri, M; Soininen, H; Hyötyläinen, T; Basignani, C. 2018. Frontiers in neuroscience. 11: 747 A1 Journal article (refereed), original research -
The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity - the FINGER Randomized Controlled Trial
Marengoni, A; Rizzuto, D; Fratiglioni, L; Antikainen, R; Laatikainen, T; Lehtisalo, J; Peltonen, M; Soininen, H; Strandberg, T; Tuomilehto, J; Kivipelto, M; Ngandu, T. 2018. Journal of the american medical directors association. 19: 355-360.e1 A1 Journal article (refereed), original research -
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Bis, JC; Jian, X; Kunkle, BW; Chen, Y; Hamilton-Nelson, KL; Bush, WS; Salerno, WJ; Lancour, D; Ma, Y; Renton, AE; Marcora, E; Farrell, JJ; Zhao, Y; Qu, L; Ahmad, S; Amin, N; Amouyel, P; Beecham, GW; Below, JE; Campion, D; et al [ Incl Helisalmi, Seppo; HIltunen, Mikko; Remes, Anne; Soininen, Hilkka]. 2018. Molecular psychiatry. [Published: 14 August 2018]: 1-17 A1 Journal article (refereed), original research -
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
Soininen Hilkka, Solomon Alina, Jelle Visser Pieter, Hendrix Suzanne B, Blennow Kaj, Kivipelto Miia, Hartmann Tobias, LipiDiDiet clinical study group. 2017. The Lancet Neurology. 16: 965-975 A1 Journal article (refereed), original research -
A Multi-Cohort Study of ApoE e4 and Amyloid-ß Effects on the Hippocampus in Alzheimer's Disease
Khan W, Giampietro V, Banaschewski T, Barker GJ, Bokde ALW, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaître H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka MN, Ströhle A et al.. 2017. Journal of Alzheimer's disease. 56: 1159-1174 A1 Journal article (refereed), original research -
Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus
Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Journal of Alzheimer's disease. 60: 1077-1085 A1 Journal article (refereed), original research -
Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study
Reijs BLR, Vos SJB, Soininen H, Lötjonen J, Koikkalainen J, Pikkarainen M, Hall A, Vanninen R, Liu Y, Herukka SK, Freund-Levi Y, Frisoni GB, Frölich L, Nobili F, Rikkert MO, Spiru L, Tsolaki M, Wallin ÅK, Scheltens P1, Verhey F, Visser PJ. 2017. Journal of Alzheimer's disease. 60: 1387-1395 A1 Journal article (refereed), original research -
Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease
Kim Min, Nevado-Holgado Alejo, Whiley Luke, Snowden Stuart G, Soininen Hilkka, Kloszewska Iwona , Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Thambisetty Madhav, Dobson Richard JB, Powell John F, Lupton Michelle K, Simmons Andyi, Velayudhan Latha, Lovestone Simon, Proitsi Petroula, Legido-Quigley Cristina. 2017. Journal of Alzheimer's disease. 60: 809-817 A1 Journal article (refereed), original research -
Association of Cerebral Amyloid-ß Aggregation With Cognitive Functioning in Persons Without Dementia
Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J et al.. 2017. JAMA psychiatry. 75: 84-95 A1 Journal article (refereed), original research -
Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis
Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, Lupton MK, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Powell JF, Dobson RJ, Legido-Quigley C. 2017. Alzheimer's & dementia. 13: 140-151 A1 Journal article (refereed), original research -
Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition
Stephen R, Liu Y, Ngandu T, Rinne JO, Kemppainen N, Parkkola R, Laatikainen T, Paajanen T, Hänninen T, Strandberg T, Antikainen R, Tuomilehto J, Keinänen Kiukaanniemi S, Vanninen R, Helisalmi S, Levälahti E, Kivipelto M, Soininen H, Solomon A. 2017. Journal of Alzheimer's disease. 59: 695-705 A1 Journal article (refereed), original research -
Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
Sindi Shireen, Ngandu Tiia, Hovatta Iiris, Kåreholt Ingemar, Antikainen Riitta, Hänninen Tuomo, Levälahti Esko, Laatikainen Tiina, Lindström Jaana, Paajanen Teemu, Peltonen Markku, Khalsa Dharma Singh, Wolozin Benjamin, Strandberg Timo, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia, Solomon Alina. 2017. Journal of Alzheimer's disease. 59: 1459-1470 A1 Journal article (refereed), original research -
Brain amyloid load and its associations with cognition and vascular risk factors in FINGER study
Kemppainen Nina, Johansson Jarkko, Teuho Jarmo, Parkkola Riitta, Joutsa Juho, Ngandu Tiika, Solomon Alina, Stephen Ruth, Liu Yawu, Hänninen Tuomo, Paajanen Teemu, Laatikainen Tiina, Soininen Hilkka, Jula Antti, Rokka Johanna, Rissanen Eero, Vahlberg Tero, Peltoniemi Julia, Kivipelto Miia, Rinne Juha O. 2017. Neurology. 2018; 90: e206-e213 A1 Journal article (refereed), original research -
Cardiorespiratory fitness and brain volumes in men and women in the FINGER study
Pentikäinen Heikki, Ngandu Tiia, Liu Yawu, Savonen Kai, Komulainen Pirjo, Hallikainen Merja, Kivipelto Miia, Rauramaa Rainer, Soininen Hilkka. 2017. Age and ageing. 46: 310-313 A1 Journal article (refereed), original research -
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants
Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD et al.. 2017. PLoS ONE. 12: e0185777 A1 Journal article (refereed), original research -
Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline
Bos Isabelle, Verhey Frans R, Ramakers Inez HGB, Jacobs Heidi IL, Soininen Hilkka, Freund-Levi Yvonne, Hampel Harald, Tsolaki Magda, Wallin Åsa K, van Buchem Mark A, Oleksik Ania, Verbeek Marcel M, Rikkert Marcel Olde, van der Flier Wiesje M, Scheltens Philip, Aalten Pauline, Visser Pieter Jelle, Vos Stephanie JB. 2017. Alzheimer's research and therapy. 9: 101 A1 Journal article (refereed), original research -
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation. : 215 A1 Journal article (refereed), original research -
Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers
Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Annals of neurology. 82: 128-132 A1 Journal article (refereed), original research -
Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting
Tong T, Ledig C, Guerrero R, Schuh A, Koikkalainen J, Tolonen A, Rhodius H, Barkhof F, Tijms B, Lemstra AW, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, Baroni M, Lötjönen J, Flier WV, Rueckert D. 2017. Neuroimage : clinical. 15: 613-624 A1 Journal article (refereed), original research -
Genetic risk factors in Finnish patients with Parkinson's disease
Ylönen Susanna, Siitonen Ari, Nalls Michael A, Ylikotila Pauli, Autere Jaana, Eerola-Rautio Johanna, Gibbs Raphael, Hiltunen Mikko, Tienari Pentti J, Soininen Hilkka, Singleton Andrew B, Majamaa Kari. 2017. Parkinsonism and related disorders. 45: 39-43 A1 Journal article (refereed), original research -
Health-related quality of life in a multidomain intervention trial to prevent cognitive decline (FINGER)
Strandberg TE, Levälahti E, Ngandu T, Solomon A, Kivipelto M, Lehtisalo J, Laatikainen T, Soininen H, Antikainen R, Jula A, Tuomilehto J, Peltonen M, Lindström J, Rauramaa R, Pajala S, Hänninen T, Solomon A, Paajanen T, Mangialasche F, FINGER Study Group. 2017. European geriatric medicine. 8: 164-167 A1 Journal article (refereed), original research -
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
van Waalwijk van Doorn LC, Gispert JD, Kuiperij HB, Claassen, JAHR, Arighi A, Baldeiras I, Blennow K, Bozzali M, Castelo-Branco M, Cavedo E, Emek-Savas D, Eren E, Eusebi P, Farotti L, Fenoglio C, Ormaechea JF, Freund-Levi Y, Frisoni G, Galimberti D, Genc S et al. 2017. Journal of Alzheimer's disease. 56: 543-555 A1 Journal article (refereed), original research -
Improving data sharing in research with context-free encoded missing data
Hoevenaar-Blom MP, Guillemont J, Ngandu T, Beishuizen CRL, Coley N, Moll van Charante EP, Andrieu S, Kivipelto M, Soininen H, Brayne C, Meiller Y, Richard E. 2017. PLoS ONE. 12: e0182362 A1 Journal article (refereed), original research -
Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy
Sindi, Shireen; Kåreholt, Ingemar; Spulber, Gabriela; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2017. Journal of Alzheimer's disease reports. 1: 219-227 A1 Journal article (refereed), original research -
Midlife work-related stress is associated with late-life cognition
Sindi S, Kåreholt I, Solomon A, Hooshmand B, Soininen H, Kivipelto M. 2017. Journal of neurology. 264: 1996-2002 A1 Journal article (refereed), original research -
Mitochondrial genes are altered in blood early in Alzheimer's disease
Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Schalkwyk L, Dobson R, Malik AN, Powell J, Lovestone S, Hodges A. 2017. Neurobiology of aging. 53: 36-47 A1 Journal article (refereed), original research -
New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1
Takalo Mari, Natunen Teemu, Leskelä Stina, Paldanius Kaisa MA, Soininen Hilkka, Hiltunen MIkko, Haapasalo Annakaisa. 2017. Journal of Alzheimer's disease & Parkinsonism. 7: 365 A2 Review article, Literature review, Systematic review -
No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease
Lupton MK, Benyamin B, Proitsi P, Nyholt DR, Ferreira MA, Montgomery GW, Heath AC, Madden PA, Medland SE, Gordon SD, Lovestone S, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Vellas B, Powell JF, Bush AI, Wright MJ, Martin NG, Whitfield JB. 2017. Journal of Alzheimer's disease. 59: 85-99 A1 Journal article (refereed), original research -
Novel genetic loci associated with hippocampal volume
Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L et al.. 2017. Nature communications. 8: 13624 A1 Journal article (refereed), original research -
Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial
Lehtisalo Jenni, Ngandu Tiia, Valve Päivi, Antikainen Riitta, Laatikainen Tiina, Strandberg Timo, Soininen Hilkka, Tuomilehto Jaakko, Kivipelto Miia, Lindström Jaana. 2017. British journal of nutrition. 118: 291-302 A1 Journal article (refereed), original research -
Postmenopausal hormone therapy and Alzheimer disease. A prospective cohort study
Imtiaz B, Tuppurainen M, Rikkonen T, Kivipelto M, Soininen H, Kröger H, Tolppanen A-M. 2017. Neurology. 88: 1062-1068 A1 Journal article (refereed), original research -
Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers
Handels RL, Vos SJ, Kramberger MG, Jelic V, Blennow K, van Buchem M, van der Flier W, Freund-Levi Y, Hampel H, Olde Rikkert M, Oleksik A, Pirtosek Z, Scheltens P, Soininen H, Teunissen C, Tsolaki M, Wallin AK, Winblad B, Verhey FR, Visser PJ. 2017. Alzheimer's & dementia. 13: 903-912 A1 Journal article (refereed), original research -
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADGC, EADI. 2017. Nature genetics. 49: 1373-1384 A1 Journal article (refereed), original research -
Risk of Alzheimer's disease among users of postmenopausal hormonetherapy: A nationwide case-control study
Imtiaz B, Taipale H, Tanskanen A, Tiihonen M, Kivipelto M, Heikkinen A-M, Tiihonen J, Soininen H, Hartikainen S, Tolppanen A-M. 2017. Maturitas. 98: 7-13 A1 Journal article (refereed), original research -
The Modified Frontal Behavioral Inventory (FBI-mod) for Patients with Frontotemporal Lobar Degeneration, Alzheimer's Disease, and Mild Cognitive Impairment
Suhonen NM, Hallikainen I, Hänninen T, Jokelainen J, Krüger J, Hall A, Pikkarainen M, Soininen H, Remes AM. 2017. Journal of Alzheimer's disease. 56: 1241-1251 A1 Journal article (refereed), original research -
The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
Bos I, Vos SJ, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E, Engelborghs S, Niemantsverdriet E, De Roeck EE, Tsolaki M, Freund-Levi Y, Johannsen P, Vandenberghe R, Lleó A, Alcolea D, Frisoni GB, Galluzzi S, Nobili F et al., the Alzheimer's Disease Neuroimaging Initiative. 2017. Neurobiology of aging. 56: 33-40 A1 Journal article (refereed), original research -
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. Alzheimer's research and therapy. 9: 31 A2 Review article, Literature review, Systematic review -
The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals
Ferreira D, Hansson O, Barroso J, Molina Y, Machado A, Hernández-Cabrera JA, Muehlboeck J-S, Stomrud E, Nägga K, Lindberg O, Ames D, Kalpouzos G, Fratiglioni L, Bäckman L, Graff C, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H et al. and for the AddNeuroMed consortium, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), for the Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) research group. 2017. Hippocampus. 27: 653-667 A1 Journal article (refereed), original research -
Why does the health-related quality of life in idiopathic normal pressure hydrocephalus fail to improve despite the favorable clinical outcome?
Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2017. World neurosurgery. 108: 356-366 A1 Journal article (refereed), original research -
Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study
Jongstra Susan, Beishuizen Cathrien, Andrieu Sandrine, Barbera Mariagnese, van Dorp Matthijs, van de Groep Bram, Guillemont Juliette, Mangialasche Francesca, van Middelaar Tessa, Moll van Charante Eric, Soininen Hilkka, Kivipelto Miia, Richard Edo. 2016. Telemedicine and e-health. 2017; 23: 1-9 A1 Journal article (refereed), original research -
Development of a Late-Life Dementia Prediction Index with Supervised Machine Learning in the Population-Based CAIDE Study
Pekkala Timo, Hall Anette, Lötjönen Jyrki, Mattila Jussi, Soininen Hilkka, Ngandu Tiia, Laatikainen Tiina, Kivipelto Miia, Solomon Alina. 2016. Journal of Alzheimer's disease. 2017; 55: 1055-1067 A1 Journal article (refereed), original research -
Differential diagnosis of neurodegenerative diseases using structural MRI data
Koikkalainen J, Rhodius-Meester H, Tolonen A, Barkhof F, Tijms B, Lemstra AW, Tong T, Guerrero R, Schuh A, Ledig C, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, van der Flier W, Lötjönen J. 2016. Neuroimage : clinical. 11: 435-449 A1 Journal article (refereed), original research -
Disrupted network topology in patients with stable and progressive mild cognitive impairment and Alzheimer's disease
Pereira Joana B, Mijalkov Mite, Kakaei Ehsan, Mecocci Patricia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Spenger Christian, Lovestone Simmon, Simmons Andrew, Wahlund Lars-Olof, Volpe Giovanni, Westman Eric, AddNeuroMed consortium, for the Alzheimer's Disease Neuroimaging Initiative. 2016. Cerebral cortex. First published online: May 13, 201: 3476-3493 A1 Journal article (refereed), original research -
Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Journal of Alzheimer's disease. 2017; 55: 995-1003 A1 Journal article (refereed), original research -
Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study
Imtiaz Bushra, Tolppanen Anna-Maija, Solomon Alina, Soininen Hilkka, Kivipelto Miia. 2016. Journal of Alzheimer's disease. 2017; 56: 453-458 A1 Journal article (refereed), original research -
Familial idiopathic normal pressure hydrocephalus
Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Journal of the neurological sciences. 368: 11-18 A1 Journal article (refereed), original research -
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B. 2016. Molecular psychiatry. [Epub ahead of print]: 1-10 A1 Journal article (refereed), original research -
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ et al, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, Enigma Consortium (incl. Soininen H). 2016. Nature neuroscience. 19: 420-431 A1 Journal article (refereed), original research -
Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study
Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. 2016. European journal of neurology. 24: 58-66 A1 Journal article (refereed), original research -
Healthy ageing through internet counselling in the elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment
Richard Edo, Jongstra Susan, Soininen Hilkka, Brayne Carol, Moll van Charante Eric P, Meiller Yannick, van der Groep Bram, Beishuizen Cathrien RL, Mangialasche Francesca, Barbera Mariagnese, Ngandu Tiia, Coley Nicola, Guillemont Juliette, Savy Stéphanie, Dijkgraaf Marcel GW, Peters Ron JG, van Gool Willem A, Kivipelto Miia, Andrieu Sandrine. 2016. BMJ open. 6: e010806 A1 Journal article (refereed), original research -
High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1
Koivisto Anne M, Kurki Mitja, Alafuzoff Irina, Sutela Anna, Rummukainen Jaana, Savolainen Sakari, Vanninen Ritva, Jääskeläinen Juha E, Soininen Hilkka, Leinonen Ville. 2016. Journal of Alzheimer's disease. 52: 497-507 A1 Journal article (refereed), original research -
Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning
Kulmala Jenni, Ngandu Tiia, Pajala Satu, Lehtisalo Jenni, Levälahti Esko, Antikainen Riitta, Laatikainen Tiina, Oksa Heikki, Peltonen Markku, Raurama Rainer, Soininen Hilkka, Strandberg Timo, Tuomilehto Jaakko, Kivipelto Miia. 2016. Journal of physical activity and health. 13: 1079-1087 A1 Journal article (refereed), original research -
Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations
Orellana C, Ferreira D, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Wahlund LO, Westman E, AddNeuronMed consortium and for the Alzheimer''s Disease Neuroimaging Initiative. 2016. Neurodegenerative diseases. 16: 77-86 A1 Journal article (refereed), original research -
Midlife work-related stress increases dementia risk in later life: the CAIDE 30-year study
Sindi Shireen, Hagman Göran, Håkansson Krister, Kulmala Jenni, Nilsen Charlotta, Kåreholt Ingemar, Soininen Hilkka, Solomon Alina, Kivipelto Miia. 2016. Journals of gerontology series b: psychological sciences and social sciences. 2017; 72: 1044-1053 A1 Journal article (refereed), original research -
Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data
Halbgebauer Steffen, Nagl Magdalena, Klafki Hans, Haußmann Ute, Steinacker Petra, Oeckl Patrick, Kassubek Jan, Pinkhardt Elmar, Ludolph Albert C, Soininen Hilkka, Herukka Sanna-Kaisa, Wiltfang Jens, Otto Markus. 2016. Scientific reports. 6: 1-8 A1 Journal article (refereed), original research -
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica. 158: 2311-2319 A1 Journal article (refereed), original research -
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS et al. 2016. Nature neuroscience. 19: 1569-1582 A1 Journal article (refereed), original research -
SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. Journal of cell science. 129: 2224-2238 A1 Journal article (refereed), original research -
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
Lupton Michelle K, Strike Lachlan, Hansell Narelle K, Wen Wei, Mather Karen A, Armstrong Nicola J, Thalamuthu Anbupalam, McMahon Katie L, de Zubicaray Greig I, Assareh Amelia A, Simmons Andrew, Proitsi Petroula, Powell John F, Montgomery Grant W, Hibar Derrek P, Westman Eric, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Mecocci Patrizia, Velas Bruno et al, Alzheimer's Disease Neuroimaging Initiative. 2016. Neurobiology of aging. 40: 68-77 A1 Journal article (refereed), original research -
Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease
Rinne JO, Wesnes K, Cummings JL, Hakulinen P, Hallikainen M, Hänninen J, Murphy M, Riordan H, Scheinin M, Soininen H, Rouru J. 2016. Alzheimer's & dementia : Translational research & clinical interventions. 2017; 3: 1-9 A1 Journal article (refereed), original research -
Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease
Muñoz-Ruiz MÁ, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Husso M, Hänninen T, Vanninen R, Liu Y, Hallikainen M, Lötjönen J, Remes AM, Alafuzoff I, Soininen H, Hartikainen P. 2016. Dementia and geriatric cognitive disorders. 6: 313-329 A1 Journal article (refereed), original research -
Voiko muistisairautta ehkäistä
Soininen Hilkka. 2016. Memo: muistisairaiden ihmisten hoidon ammattilehti. 1: 4-6 D1 Article in a trade journal -
Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis
Beishuizen Cathrien RL, Stephan Blossom CM, van Gool Willem A, Brayne Carol, Peters Ron JG, Andrieu Sandrine, Kivipelto Miia, Soininen Hilkka, Busschers Wim B, Moll van Charante Eric P, Richard Edo. 2016. Journal of medical internet research. 18: e55 A2 Review article, Literature review, Systematic review -
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Ngandu Tiia, Lehtisalo Jenni, Solomon Alina, Levälahti Esko, Ahtiluoto Satu, Antikainen Riitta, Bäckman Lars, Hänninen Tuomo, Jula Antti, Laatikainen Tiina, Lindström Jaana, Mangialasche Francesca, Paajanen Teemu, Pajala Satu, Peltonen Markku, Rauramaa Rainer, Stigsdotter-Neely Anna, Strandberg T, Tuomilehto J, Soininen Hilkka, Kivipelto Miia. 2015. The Lancet. 385: 2255-2263 A1 Journal article (refereed), original research -
A Pathway based classification method for analyzing gene expression for Alzheimer's disease diagnosis
Voyle Nicola, Keohane Aoife, Newhouse Stephen, Lunnon Katie, Johnston Caroline, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Hodges Angela, Kiddle Steven, Dobson Richard JB. 2015. Journal of Alzheimer's disease. 49: 659-669 A1 Journal article (refereed), original research -
A Phase II Trial of Tideglusib in Alzheimer's Disease
Lovestone Simon, Boada Mercè, Dubois Bruno, Hüll Michael, Rinne Juha O, Huppertz Hans-Jürgen, Calero Miguel, Andrés María V, Gómez-Carrillo Belén, León Teresa, del Ser Teodoro for the ARGO investigators (incl. Soininen Hilkka, Hallikainen Merja, Remes Anne). 2015. Journal of Alzheimer's disease. 45: 75-88 A1 Journal article (refereed), original research -
A novel Alzheimer disease locus located near the gene encoding tau protein
Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA et al (incl. Hilkka Soininen and Mikko Hiltunen). 2015. Molecular psychiatry. 2016; 21: 108-117 A1 Journal article (refereed), original research -
Alzheimer's disease: a report from the 7th Kuopio Alzheimer symposium
Haapasalo Annakaisa, Pikkarainen Maria, Soininen Hilkka. 2015. Neurodegenerative disease management. 5: 379-382 A1 Journal article (refereed), original research -
Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease. 46: 261-269 A1 Journal article (refereed), original research -
CSF biomarkers for the differential diagnosis of Alzheimer's disease. A large-scale international multicenter study
Ewers Michael, Mattsson Niklas, Minthon Lennart, Molinuevo José L, Antonell Anna, Popp Julius, Jessen Frank, Herukka Sanna-Kaisa, Soininen Hilkka, Maetzler Walter, Leyhe Thomas, Bürger Katharina, Taniguchi Miyako, Urakami Katsuya, Lista Simone, Dubois Bruno, Blennow Kaj, Hampel Harald. 2015. Alzheimer's & dementia. 11: 1306-1315 A1 Journal article (refereed), original research -
Common genetic variants influence human subcortical brain structures
Hibar Derrek P, Stein Jason L, Renteria Miguel E, Arias-Vasquez Alejandro, Desrivières Sylvane, Jahanshad Neda, Toro Roberto, Wittfeld Katharina, Abramovic Lucija, Andersson Micael, Aribisala Benjamin S, Armstrong Nicola J, Bernard Manon, Bohlken Marc M, Boks Marco P, Bralten Janita, Brown Andrew A, Chakravarty M Mallar, Qiang Chen, Ching Christopher RK et al. (incl. Hilkka Soininen). 2015. Nature. 520: 224-229 A1 Journal article (refereed), original research -
Dementia: Risk prediction models in dementia prevention
Solomon Alina, Soininen Hilkka. 2015. Nature reviews neurology. 11: 375-377 A1 Journal article (refereed), original research -
Early psychosocial intervention does not delay institutionalization in persons with mild Alzheimer disease and has impact on neither disease progression nor caregivers' well-being: ALSOVA 3-year follow-up
Koivisto Anne M, Hallikainen Ilona, Välimäki Tarja, Hongisto Kristiina, Hiltunen Asta, Karppi Pertti, Sivenius Juhani, Soininen Hilkka, Martikainen Janne. 2015. International journal of geriatric psychiatry. 31(2016): 273-283 A1 Journal article (refereed), original research -
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573 A1 Journal article (refereed), original research -
Feasibility of radiological markers in idiopathic normal pressure hydrocephalus
Kojoukhova Maria, Koivisto Anne M, Korhonen Riiika, Remes Anne M, Vanninen Ritva, Soininen Hilkka, Jääskeläinen Juha E, Sutela Anna, Leinonen Ville. 2015. Acta neurochirurgica. 157: 1709-1719 A1 Journal article (refereed), original research -
Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study
Håkansson Krister, Soininen Hilkka, Winblad Bengt, Kivipelto Miia. 2015. PLoS ONE. 10: e0140261 A1 Journal article (refereed), original research -
Generalizability of the Disease State Index Prediction Model for Identifying Patients Progressing from Mild Cognitive Impairment to Alzheimer's Disease
Hall Anette, Muñoz-Ruiz Miguel, Mattila Jussi, Koikkalainen Juha, Tsolaki Magda, Mecocci Patrizia, Kloszewska Iwona, Vellas Bruno, Lovestone Simon, Visser Pieter Jelle, Lötjonen Jyrki, Soininen Hilkka. 2015. Journal of Alzheimer's disease. 44: 79-92 A1 Journal article (refereed), original research -
Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease
Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 48: 507-516 A1 Journal article (refereed), original research -
Health-related quality of life in patients with idiopathic normal pressure hydrocephalus
Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 2015. European journal of neurology. published online 24 JUN 2015: 9 p A1 Journal article (refereed), original research -
Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Progress in neurobiology. epub ahead of print 19 May 2015: A1 Journal article (refereed), original research -
Kliinis-neurofysiologiset tutkimukset
Soininen Hilkka, Partanen Juhani V. Teoksessa: Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka(toim.) , 2015. Muistisairaudet. s. 419-425. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts
Khondoker Mizanur, Newhouse Stephen, Westman Eric, Muehlboeck J-Sebastian, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Lovestone Simon, Dobson Richard, Simmons Andrew, and for the AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. 2015. Journal of Alzheimer's disease. 45: 851-864 A1 Journal article (refereed), original research -
Long-Term Response to Cholinesterase Inhibitor Treatment Is Related to Functional MRI Response in Alzheimer's Disease
Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. 2015. Dementia and geriatric cognitive disorders. 40: 243-255 A1 Journal article (refereed), original research -
Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease
Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Dobson RJ. 2015. Journal of Alzheimer's disease. 49: 1105-1114 A1 Journal article (refereed), original research -
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Steinberg Stacy, Stefansson Hreinn, Jonsson Thorlakur, Johannsdottir Hrefna, Ingason Andres, Helgason Hannes, Sulem Patrick, Magnusson Olafur Th, Gudjonsson Sigurjon A, Unnsteinsdottir Unnur, Kong Augustine, Helisalmi Seppo, Soininen Hilkka, Lah James J, DemGene, Aarsland Dag, Fladby Tormod, Ulstein Ingun D, Djurovic Srdjan, Sando Sigrid B (incl. Hiltunen Mikko). 2015. Nature genetics. 47: 445-447 A1 Journal article (refereed), original research -
Midlife CAIDE Dementia Risk Score and Dementia-Related Brain Changes up to 30 Years Later on Magnetic Resonance Imaging
Vuorinen Miika, Spulber Gabriela, Soheil Damingir, Niskanen Eini, Ngandu Tiia, Soininen Hilkka, Kivipelto Miia, Soloman Alina. 2015. Journal of Alzheimer's disease. 44: 93-101 A1 Journal article (refereed), original research -
Muistioireiden taudinmääritys
Soininen Hilkka, Hänninen Tuomo. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 81-89. Kustannus Oy Duodecim A3 Book section, Chapters in research books -
Muistisairaudet
Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka (toim.). 2015. . 2., uudistettu painos. Kustannus Oy Duodecim C2 Edited book, conference proceedings or special issue of a journal -
Muistisairaudet: käsitteitä ja termejä
Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka. Teoksessa: Erkinjuntti Timo, Remes Anne, Rinne Juha, Soininen Hilkka(toim.) , 2015. Muistisairaudet. s. 18-22. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Muistisairauksien ennaltaehkäisy
Soininen Hilkka, Kivipelto Miia. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen(toim.) , 2015. Muistisairaudet. s. 436-445. Kustannus Oy Duodecim A3 Book section, Chapters in research books -
No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease
Chiam Justin Tao Wen, Lunnon Katie, Voyle Nicola, Proitsi Petroula, Coppola Giovanni, Geschwind Daniel, Nelson Sally, Johnston Caroline, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Hodges Angela, Lovestone Simon, Newhouse Stephen, Dobson Richard James Butler, Kiddle Steven John, Sattlecker Martina. 2015. Journal of Alzheimer's disease. 47: 741-750 A1 Journal article (refereed), original research -
Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation
Boccardi Marina, Bocchetta Martina, Ganzola Rossana, Rabitaille Nicholas, Redolfi Alberto, Duchesne Simon, Jack Jr. Clifford R, Frisoni Giovanni B, Bartzokis G. Csemansky JG, de Leon MJ, de Toledo-Morrell L., Killiany RJ, Lehéricy S. Malykhin N. Pantel J. Pruessner JC, Soininen H., Watson C.. 2015. Alzheimer's & dementia. 11: 184-194 A1 Journal article (refereed), original research -
Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease
Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Sham P, Lovestone S, Powell JF, Dobson RJB, Legido-Quigley C. 2015. Translational psychiatry. 5: e494 A1 Journal article (refereed), original research -
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes
Kiddle S J, Steves C J, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton N J, Bazenet C, Killick R, Adnan J, Westman E, Nelson S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Curtis C, Breen G, Williams S C R, Lovestone S, Spector T D, Dobson R J B. 2015. Translational psychiatry. 5: e584 A1 Journal article (refereed), original research -
Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment
Ferreira D, Cavallin L, Larsson E-M, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Wahlund L-O, Esteman E and for the AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. 2015. Journal of internal medicine. 278: 277-290 A1 Journal article (refereed), original research -
Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index
Hall Anette, Mattila Jussi, Koikkalainen Juha, Lötjonen Jyrki, Wolz Robin, Scheltens Philip, Frisoni Giovanni, Tsolaki Magdalini, Nobili Flavio, Freund-Levi Yvonne, Minthon Lennart, Frölich Lutz, Hampel Harald, Visser Pieter Jelle, Soininen Hilkka. 2015. Current alzheimer research. 12: 69-79 A1 Journal article (refereed), original research -
Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage
Vos Stephanie JB, Verhey Frans, Frölich Lutz, Kornhuber Johannes, Wiltfang Jens, Maier Wolfgang, Peters Oliver, Rüther Eckart, Nobili Flavio, Morbelli Silvia, Frisoni Giovanni B, Drzezga Alexander, Didic Mira, van Berckel Bart NM, Simmons Andrew, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Muscio Cristina, Herukka Sanna-Kaisa, Salmon Eric, Bastin Christine, Wallin Anders, Nordlund Arto, de Mendonça Alexandre, Silva Dina, Santana Isabel, Lemo. 2015. Brain. 138: 1327-1338 A1 Journal article (refereed), original research -
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia A Meta-analysis
Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewic. 2015. JAMA : Journal of the American Medical Association. 313: 1924-1938 A1 Journal article (refereed), original research -
Protective Variant for Hippocampal Atrophy Identified by Whole Exome Sequencing
Nho Kwangsik, Kim Sungeun, Risacher Shannon L, Shen Li, Corneveaux Jason J, Swaminathan Shanker, Lin Hai, Ramanan Vijay K, Liu Yunlong, Foroud Tatiana M, Inlow Mark H, Siniard Ashley L, Reiman Rebecca A, Aisen Paul S, Petersen Ronald C, Green Robert C, Jack Jr Clifford R, Weiner Michael W, Baldwin Clinton T, Lunetta Kathryn L, Farrer Lindsay A, Furney Simon J, Lovestone Simon, Simmons Andrew, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, McDonald Brenna C, Far. 2015. Annals of neurology. 77: 547-552 A1 Journal article (refereed), original research -
Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition
Ferreira Daniel, Cavallin Lena, Granberg Tobias, Lindberg Olof, Aguilar Carlos, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Lovestone Simon, Simmons Andrew, Wahlund Lars-Olof, Westman Eric for the AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. 2015. European radiology. [first online 11 Nov 2015]: 1-14 A1 Journal article (refereed), original research -
Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol
Apostolova Liana G, Zarow Chris, Biado Kristina, Hurtz Sona, Boccardi Marina, Somme Johanne, Honarpisheh Hedieh, Blanken Anna E, Brook Jenny, Tung Spencer, Kraft Emily, Lo Darrick, Ng Denise, Alger Jeffry R, Vinters Harry V, Bocchetta Martina, Duvernoy Henri, R. Jack Jr Clifford R, Frisoni Giovanni B for the EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation (incl. Soininen Hilkka). 2015. Alzheimer's & dementia. 11: 139-150 A1 Journal article (refereed), original research -
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205 A1 Journal article (refereed), original research -
Synaptic dysfunction and septin protein family members in neurodegenerative diseases
Marttinen Mikael, Kurkinen Kaisa MA, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Molecular neurodegeneration. 10: 12 p A2 Review article, Literature review, Systematic review -
Targeting prodromal Alzheimer disease with avagacestat: a randomized clinical trial
Coric Vladimir, Salloway Stephen, van Dyck Christopher H, Dubois Bruno, Andreasen Niels, Brody Mark, Curtis Craig, Soininen Hilkka, Thein Stephen, Shiovitz Thomas, Pilcher Gary, Ferris Steven, Colby Susan, Kerselaers Wendy, Dockens Randy, Soares Holly, Kaplita Stephen, Luo Feng, Pachai Chahin, Bracoud Luc, Mintun Mark, Grill Joshua D, Marek Ken, Seibyl John, Cedarbaum Jesse M, Albright Charles, Feldman Howard H, Berman Robert M. 2015. JAMA neurology. 72: - A1 Journal article (refereed), original research -
The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia
Sindi Shireen, Calov Elisabeth, Fokkens Jasmine, Ngandu Tiia, Soininen Hilkka, Tuomilehto Jaakko, Kivipelto Miia. 2015. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 1: 328-333 A1 Journal article (refereed), original research -
The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects
Falahati Farshad, Ferreira Daniel, Soininen Hilkka, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Lovestone Simon, Eriksdotter Maria, Wahlund Lars-Olof, Simmons Andrew, Westman Eric; for the AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. 2015. Brain topography. 2016; 29: 296-307 A1 Journal article (refereed), original research -
The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. Journal of Alzheimer's disease. 48: 959-968 A1 Journal article (refereed), original research -
Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study
Zwan Marissa D, Rinne Juha O, Hasselbalch Steen G, Nordberg Agneta, Lleó Alberto, Herukka Sanna-Kaisa, Soininen Hilkka, Law Ian, Bahl Justyna MC, Carter Stephen F, Fortea Juan, Blesa Rafael, Teunissen Charlotte E, Bouwman Femke H, van Berckel Bart NM, Visser Pieter J. 2015. Neurology. 86 (2016): 50-58 A1 Journal article (refereed), original research -
A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's Disease
Hartmann Tobias, van Wijk Nick, Wurtmann Richard J, Olde Rikkert Marcel GM, Sijben John WC, Soininen Hilkka, Vellas Bruno, Scheltens Philip. 2014. Journal of Alzheimer's disease. 41: 715-717 A1 Journal article (refereed), original research -
Aivosairaudet ovat kalleimmat kansantautimme
Lindsberg Perttu J, Castrén Eero, Korkeila Jyrki, Alho Hannu, Erkinjuntti Timo, Isometsä Erkki, Kalso Eija, Marttunen Mauri, Pihko Helena, Tienari Pentti, Wartiovaara Anu, Jäkälä Pekka, Kälviäinen Reetta, Soininen Hilkka, Tiihonen Jari, Karlsson Hasse, Rinne Juha, Roine Risto O, Elovaara Irina, Tamminen Tuula, Öhman Juha, Majamaa Kari, Hari Riitta. 2014. Duodecim. 130: 1721-1730 A1 Journal article (refereed), original research -
Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease
Proitsi P, Lupton MK, Velayudhan L, Hunter G, Newhouse S, Lin K, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Craig D, Todd S, Johnston JA, McGuinness B, Kloszewska I, Soininen H, Mecocci P, Vellas B, Passmore PA, Sims R, et al.. 2014. Neurobiology of aging. [Epub ahead of print]: x-x A1 Journal article (refereed), original research -
Altered cerebrospinal fluid levels of amyloid beeta and amyloid precursor-like protein 1 peptides in Down's Syndrome
Portelius Erik, Hölttä Mikko, Soininen Hilkka, Bjerke Maria, Zetterberg Henrik, Westerlund Anni, Herukka Sanna-Kaisa, Blennow Kaj, Mattsson Niklas. 2014. Neuromolecular medicine. 16: 510-516 A1 Journal article (refereed), original research -
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Sattlecker Martina, Kiddle Steven J, Newhouse Stephen, Proitsi Petroula, Nelson Sally, Williams Stephen, Johnston Caroline, Killick Richard, Simmons Andrew, Westman Eric, Hodges Angela, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Dobson Richard JB. 2014. Alzheimer's & dementia. Epub April 2014: 1-11 A1 Journal article (refereed), original research -
Alzheimer's disease-related plaques in nondemented subjects
Elobeid Adila, Rantakömi Sanna, Soininen Hilkka, Alafuzoff Irina. 2014. Alzheimer's & dementia. Epub April 2014: 1-8 A1 Journal article (refereed), original research -
Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort
Aquilar C, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Wahlund L-O, Simmons A, Westman E. 2014. Frontiers in aging neuroscience. 6: 1-12 A1 Journal article (refereed), original research -
Application of the PredictAD Decision Support Tool to a Danish Cohort of Patients with Alzheimer's Disease and Other Dementias
Simonsen AH, Mattila J, Hejl AM, Garde E, van Gils M, Thomsen C, Lötjönen J, Soininen H, Waldemar G. 2014. Dementia and geriatric cognitive disorders. 37: 207-213 A1 Journal article (refereed), original research -
Association between mid- to late life physical fitness and dementia: evidence from the CAIDE study
Kulmala J, Solomon A, Kåreholt I, Ngandu T, Rantanen T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M. 2014. Journal of internal medicine. 276: 296-307 A1 Journal article (refereed), original research -
Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts
Khan W, Westman E, Jones N, Wahlund LO, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Muehlboeck JS, Simmons A, for the AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. 2014. Brain topography. Epub: - A1 Journal article (refereed), original research -
Behavioural and ERP effects of paradigm complexity on visual word recognition
Nikolaev Alexandre, Pääkkönen Ari, Niemi Jussi, Nissi Mikko J, Niskanen Eini, Könönen Mervi, Mervaala Esa, Soininen Hilkka. 2014. Language, cognition and neuroscience. 29: 1295-1310 A1 Journal article (refereed), original research -
Candidate Blood Proteome Markers of Alzheimer's Disease Onset and Progression: A Systematic Review and Replication Study
Kiddle SJ, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, Nelson SK, Williams S, Hodges A, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Newhouse S, Lovestone S, Dobson RJ. 2014. Journal of Alzheimer's disease. 38: 515-531 A2 Review article, Literature review, Systematic review -
Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus
Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. PLoS ONE. 9: 1-10 A1 Journal article (refereed), original research -
Circulating proteomic signatures of chronological age
Menni Cristina, Kiddle Steven J, Mangino Massimo, Vinuela Ana, Psatha Maria, Steves Claire, Sattlecker Martina, Buil Alfonso, Newhouse Stephen, Nelson Sally, Williams Stephen, Voyle Nicola, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Spector Tim D, Dobson Richard, Valdes Ana M. 2014. Journals of gerontology series a: biological sciences and medical sciences. -: 1-9 A1 Journal article (refereed), original research -
Convergent genetic and expression data implicate immunity in Alzheimer's disease
Jones L, Lambert J, Wang L, Choi S, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards A, Bellenguez C, Ibrahim-Verbaas CA, Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis JC, Beecham GW, Grenier-Boley B, ..., Soininen H, et al., (International Genomics of Alzheimer's Disease Consortium (IGAP); International Genomics of Alzheimer's Disease Consortium IGAP). 2014. Alzheimer's & dementia. 2014: 1-14 A1 Journal article (refereed), original research -
Coronary Heart Disease and Cortical Thickness, Gray Matter and White Matter Lesion Volumes on MRI
Vuorinen Miika, Damangir Soheil, Niskanen Eini, Miralbell Julia, Rusanen Minna, Spulber Gabriela, Soininen Hilkka, Kivipelto Miia, Solomon Alina. 2014. PLoS ONE. 9: e109250, 1-9 A1 Journal article (refereed), original research -
Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance
Boccardi Marina, Bocchetta Martina, Apostolova Liana G, Barnes Josephine, Bartzokis George, Corbetta Gabriele, DeCarli Charles, deToledo-Morrell Leyla, Firbank Michael, Ganzola Rossana, Gerritsen Lotte, Henneman Wouter, Killiany Ronald J, Malykhin Nikolai, Pasqualetti Patrizio, Pruessner Jens C, Redolfi Alberto, Robitaille Nicolas, Soininen Hilkka et al. 2014. Alzheimer's & dementia. -: 1-13 A1 Journal article (refereed), original research -
Exploring Alzheimer Molecular Pathology in Down's Syndrome Cerebrospinal Fluid
Portelius Erik, Soininen Hilkka, Andreasson Ulf, Zetterberg Henrik, Persson Rita, Karlsson Gösta, Blennow Kaj, Herukka Sanna-Kaisa, Mattsson Niklas. 2014. Neurodegenerative diseases. 14: 98-106 A1 Journal article (refereed), original research -
FASTKD2 is associated with memory and hippocampal structure in older adults
Ramanan VK, Nho K, Shen L, Risacher SL, Kim S, McDonald BC, Farlow MR, Foroud TM, Gao S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, De Jager PL, Yu L, Bennett DA, Saykin AJ. 2014. Molecular psychiatry. 2014: 1-8 A1 Journal article (refereed), original research -
Functional MRI in Alzheimer's Disease
Kivistö Julia, Soininen Hilkka, Pihlajamäki Maija. Teoksessa: Papageorgiou D, Christopoulos GI, Smirnakis SM(toim.) , 2014. Advanced Brain Neuroimaging Topics in Health and Disease - Methods and Applications. s. 497-519. Intech media A3 Book section, Chapters in research books -
Future directions in Alzheimer's disease from risk factors to prevention
Imtiaz Bushra, Tolppanen Anna-Maija, Kivipelto Miia, Soininen Hilkka. 2014. Biochemical pharmacology. 88: 661-670 A2 Review article, Literature review, Systematic review -
Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease
Escott-Price V, Bellenguez C, Wang L-S, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert J-C, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA et.al.. 2014. PLoS ONE. 9: e94661 A1 Journal article (refereed), original research -
Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B; Alzheimer's Disease Neuroimaging Initiative, Williams J; GERAD1 Consortium, Stewart R, Sham P, Lovestone S, Powell JF. 2014. PLoS medicine. 11: e1001713; 1-15 A1 Journal article (refereed), original research -
Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project
Bocchetta M, Boccardi M, Ganzola R, Apostolova LG, Preboske G, Wolf D, Ferrari C, Pasqualetti P, Robitaille N, Duchesne S, Jack CR Jr, Frisoni GB; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and the Alzheimer's Disease Neuroimaging Initiative; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and the Alzheimer's Disease Neuroimaging Initiative, Collaborators: Bartzokis G, DeCarli C, deToledo-Morrell L, Fellgiebel A, . 2014. Alzheimer's & dementia. 2014: Epub ahead of print A1 Journal article (refereed), original research -
Harmonized diagnostic criteria for Alzheimer's disease: recommendations
Morris JC, Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund L-O, Dubois B. 2014. Journal of internal medicine. 275: 204-213 A1 Journal article (refereed), original research -
Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study
Rusanen Minna, Kivipelto Miia, Levälahti Esko, Laatikainen Tiina, Tuomilehto Jaakko, Soininen Hilkka, Ngandu Tiia. 2014. Journal of Alzheimer's disease. 42: 183-191 A1 Journal article (refereed), original research -
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641 A1 Journal article (refereed), original research -
Hospital admissions, outpatient visits and healthcare costs of community-dwellers with Alzheimer's disease
Tolppanen Anna-Maija, Taipale Heidi, Purmonen Timo, Koponen Marjaana, Soininen Hilkka, Hartikainen Sirpa. 2014. Alzheimer's & dementia. 2015; 11: 955-963 A1 Journal article (refereed), original research -
Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology
Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. PLoS ONE. 3: 1-8 A1 Journal article (refereed), original research -
Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells
Sutinen EM, Korolainen MA, Häyrinen J, Alafuzoff I, Petratos S, Salminen A, Soininen H, Pirttilä T, Ojala JO. 2014. Frontiers in cellular neuroscience. 8: 1-16 A1 Journal article (refereed), original research -
Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort
Neuvonen Elisa, Rusanen Minna, Solomon Alina, Ngandu Tiia, Laatikainen Tiina, Soininen Hilkka, Kivipelto Miia, Tolppanen Anna-Maija. 2014. Neurology. 82: 2205-2212 A1 Journal article (refereed), original research -
Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia
Tolppanen Anna-Maija, Solomon Alina, Kulmala Jenni, Kåreholt Ingemar, Ngandu Tiia, Rusanen Minna, Laatikainen Tiina, Soininen Hilkka, Kivipelto Miia. 2014. Alzheimer's & dementia. Epub ahead of print: - A1 Journal article (refereed), original research -
Modifiable lifestyle factors in dementia: A systematic review of longitudinal observational cohort studies
Di Marco Luigi Yuri, Marzo Alberto, Munoz-Ruiz Miguel, Arfan Ikram M, Kivipelto Miia, Ruefenacht Daniel, Venneri Annalena, Soininen Hilkka, Wanke Isabel, Ventikos Yiannis A, Frangi Alejandro F. 2014. Journal of Alzheimer's disease. 42: 119-135 A1 Journal article (refereed), original research -
Oophorectomy, Hysterectomy, and Risk of Alzheimer's Disease: A Nationwide Case-Control Study
Imtiaz Bushra, Tuppurainen Marjo, Tiihonen Miia, Kivipelto Miia, Soininen Hilkka, Hartikainen Sirpa, Tolppanen Anna-Maija. 2014. Journal of Alzheimer's disease. 42: 575-581 A1 Journal article (refereed), original research -
Plasma proteins predict conversion to dementia from prodromal disease
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H et.al.. 2014. Alzheimer's & dementia. -: 1-9 A1 Journal article (refereed), original research -
Predicting progression of Alzheimer's Disease using ordinal regression
Doyle OM, Westman E, Marquand AF, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Williams SCR, Simmons A. 2014. PLoS ONE. 9: e105542 A1 Journal article (refereed), original research -
Prognostic polypeptide blood plasma biomarkers of Alzheimer's Disease progression
Yang Hongqian, Lyutvinskiy Yaroslav, Herukka Sanna-Kaisa, Soininen Hilkka, Rutishauser Dorothea, Zubarev Roman A. 2014. Journal of Alzheimer's disease. 40: 659-666 A1 Journal article (refereed), original research -
Random Forest ensembles for detection and prediction of Alzheimer's disease with a good between-cohort robustness
Lebedev AV, Westman E, Van Westen GJ, Kramberger MG, Lundervold A, Aarsland D, Soininen H, KLoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Simmons A, for the Alzheimer's Disease Neuroimaging Initiative and the AddNeuroMed consortium. 2014. Neuroimage : clinical. 6: 115-125 A1 Journal article (refereed), original research -
Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial
Ngandu Tiia, Lehtisalo Jenni, Levälahti Esko, Laatikainen Tiina, Lindström Jaana, Peltonen Markku, Solomon Alina, Ahtiluoto Satu, Antikainen Riitta, Hänninen Tuomo, Jula Antti, Mangialasche Francesca, Paajanen Teemu, Pajala Satu, Rauramaa Rainer, Strandberg Timo, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. 2014. International journal of environmental research and public health. 11: 9345-9360 A1 Journal article (refereed), original research -
The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C, Apostolova LG, ..., Soininen H, et al.. 2014. Alzheimer's & dementia. 11: 111-125 A1 Journal article (refereed), original research -
The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients
Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. Neurodegenerative diseases. 14: 204-208 A1 Journal article (refereed), original research -
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28 A1 Journal article (refereed), original research -
A blood gene expression marker of early Alzheimer's Disease
Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H et.al.. 2013. Journal of Alzheimer's disease. 33: 737-753 A1 Journal article (refereed), original research -
Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood
Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A. 2013. Neurobiology of aging. [Epub ahead of print]: 1-12 A1 Journal article (refereed), original research -
Alzheimern taudin uudet riskigeenit - tautia ennakoivat biomarkkerit?
Hiltunen M, Haapasalo A, Soininen H. 2013. Duodecim. 129: 583-588 A2 Review article, Literature review, Systematic review -
An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment
Spulber G, Simmons A, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Wahlund L-O, Westman E. 2013. Journal of internal medicine. 273: 396-409 A1 Journal article (refereed), original research -
Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study
Chincarini Andres, Bosco Paolo, Gemme Gianluca, Esposito Mario, Rei Luca, Squarcia Sandro, Bellotti Roberto, Minthon Lennart, Frisoni Giovanni, Scheltens Philip, Frölich Lutz, Soininen Hilkka, Visser Pieter-Jelle, Nobili Flavio. 2013. Alzheimer's & dementia. [Epub ahead of print]: 1-12 A1 Journal article (refereed), original research -
CERAD neuropsychological compound scores are accurate in detecting prodromal Alzheimer's Disease: A prospective AddNeuroMed Study
Paajanen T, Hänninen T, Tunnard C, Hallikainen M, Mecocci P, Sobow T, Tsolaki M, Vellas B, Lovestone S, Soininen H. 2013. Journal of Alzheimer's disease. -: - A1 Journal article (refereed), original research -
CERAD neuropsychological total score reflect cortical thinning in prodromal Alzheimer's Disease
Paajanen T, Hänninen T, Aitken A, Hallikainen M, Westman E, Wahlund L-O, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H.. 2013. Dementia and geriatric cognitive disorders. 3: 446-458 A1 Journal article (refereed), original research -
Changes in vascular factors 28 years from midlife and late-life cortical thickness
Vuorinen M, Kåreholt I, Julkunen V, Spulber G, Niskanen E, Paajanen T, Soininen H, Kivipelto M, Solomon A. 2013. Neurobiology of aging. 34: 100-109 A1 Journal article (refereed), original research -
Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study
Rusanen M, Ngandu T, Laatikainen T, Tuomilehto J, Soininen H, Kivipelto M. 2013. Current alzheimer research. 10: 549-555 A1 Journal article (refereed), original research -
Classification Models for Alzheimer's Disease Detection
Anagnostopoulos C-N, Giannoukos J, Spenger C,Simmons A, Mecocci P, Soininen H, Kloszewska I, Vellas B, Lovestone S, Tsolaki M. Teoksessa: Iliadis L, Papadopoulos H, Jayne C(toim.) , 2013. Engineering Applications of Neural Networks. s. 193-202. A4 Conference proceedings -
Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of alpha-/gamma-tocotrienols and gamma-tocopherol
Mangialasche F, Westman E, Kivipelto M, Muehlboeck J-S, Cecchetti R, Baglioni M, Tarducci R, Gobbi G, Floridi P, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Spenger C, Lovestone S, Wahlund L-O, Simmons A, Mecocci P. 2013. Journal of internal medicine. 273: 602-621 A1 Journal article (refereed), original research -
Clinical symptoms and symptom signatures of Alzheimer's Disease subgroups
Iqbal Khalid, Flory Michael, Soininen Hilkka. 2013. Journal of Alzheimer's disease. 37: 475-481 A1 Journal article (refereed), original research -
Comparing Predictors of Conversion to Alzheimer's Disease Using the Disease State Index
Muñoz-Ruiz MA, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Neurodegenerative diseases. epub ahead of print: 3 sivua A1 Journal article (refereed), original research -
Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment
Aguilar C, Westman E, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Spenger C, Simmons A, Wahlund L-O. 2013. Psychiatry research: neuroimaging. 212: 89-98 A1 Journal article (refereed), original research -
Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's Disease and mild cognitive impairment
Munoz-Ruiz MA, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Journal of Alzheimer's disease. 35: 727-739 A1 Journal article (refereed), original research -
Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease
Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700 A1 Journal article (refereed), original research -
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease
Natunen T, Parrado AR, Helisalmi S, Pursiheimo J-P, Sarajärvi T, Mäkinen P, Kurkinen KMA, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Journal of Alzheimer's disease. 37: 217-232 A1 Journal article (refereed), original research -
Entorhinal cortex thickness predicts cognitive decline in Alzheimer's Disease
Velayudhan L, Proitsi P, Westman E, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Hodges A, Powell J, Lovestone S, Simmons A. 2013. Journal of Alzheimer's disease. 33: 755-766 A1 Journal article (refereed), original research -
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
Whiley Luke, Sen Arundhuti, Heaton James, Proitsi Petroula, Garcia-Gomez Diego, Leung Rufina, Smith Norman, Thambisetty Madhav, Kloszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Legido-Quigley C. 2013. Neurobiology of aging. x: 1-8 A1 Journal article (refereed), original research -
GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. Journal of Alzheimer's disease. 33: 23-27 A1 Journal article (refereed), original research -
Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort
Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. PLoS ONE. 8: e59676 A1 Journal article (refereed), original research -
History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study
Tolppanen Anna-Maija, Lavikainen Piia, Solomon Alina, Kivipelto Miia, Uusitupa Matti, Soininen Hilkka, Hartikainen Sirpa. 2013. Diabetes care. 36: 2015-2019 A1 Journal article (refereed), original research -
Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics
Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH... Soininen H et al.. 2013. Molecular psychiatry. 18: 739 A1 Journal article (refereed), original research -
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Progress in neurobiology. 106-107: 33-54 A1 Journal article (refereed), original research -
Incidence of stroke in people with Alzheimer disease. A national register-based approach
Tolppanen Anna-Maija, Lavikainen Piia, Solomon Alina, Kivipelto Miia, Soininen Hilkka, Hartikainen Sirpa. 2013. Neurology. 80: 353-358 A1 Journal article (refereed), original research -
Incident Hip Fractures among Community Dwelling Persons with Alzheimer's Disease in a Finnish Nationwide Register-Based Cohort
Tolppanen A-M, Lavikainen P, Soininen H, Hartikainen S. 2013. PLoS ONE. 8: e59124 A1 Journal article (refereed), original research -
Incident ischaemic heart disease in persons with Alzheimer's disease in a Finnish nationwide exposure-matched cohort
Tolppanen Anna-Maija, Kettunen Raimo, Ahonen Riitta, Soininen Hilkka, Hartikainen Sirpa. 2013. International journal of cardiology. 170: 195-201 A1 Journal article (refereed), original research -
Inflammatory proteins in plasma are associated with severity of Alzheimer's Disease
Leung R, Proitsi P, Simmons A, Lunnon K, Guntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Soininen H, Wahlund L-O, Lovestone S. 2013. PLoS ONE. 8: e64971 A1 Journal article (refereed), original research -
Influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs
Pereira JB, Cavallin L, Spulber G, Aguilar C, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Aarsland D, Lovestone S, Simmons A, Wahlund L-O, Westman E. 2013. Journal of internal medicine. -: - A1 Journal article (refereed), original research -
Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment
Clerx L, van Rossum IA, Burns L, Knol DL, Scheltens P, Verhey F, Aalten P, Lapuerta P, van de Pol L, van Schijndel R, de Jong R, Barkhof F, Wolz R, Rueckert D, Bocchetta M, Tsolaki M, Nobili F, Wahlund L-O, Minthon L, Frölich L, Hampel H, Soininen H, Jelle Visser P. 2013. Neurobiology of aging. 34: 2003-2013 A1 Journal article (refereed), original research -
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Lambert JC,Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, ... Soininen H, ... Hiltunen M et al.. 2013. Nature genetics. Dec; 45 (12): 1452-8 A1 Journal article (refereed), original research -
Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort
Tolppanen A-M, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, Kivipelto M. 2013. Journal of Alzheimer's disease. online: - A1 Journal article (refereed), original research -
Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V,. 2013. Neurosurgery. 72: 1-8 A1 Journal article (refereed), original research -
Predicting AD conversion: Comparison between prodromal AD guidelines and computer assisted PredictAD tool
Liu Y, Mattila J, Muñoz Ruiz MA, Paajanen T, Koikkalainen J, van Gils M, Herukka S-K, Waldemar G, Lötjönen J, Soininen H. 2013. PLoS ONE. 8: e55246 A1 Journal article (refereed), original research -
Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI
Voss SJB, van Rossum IA, Verhey F, Knol DL, Soininen H, Wahlund L-O, Hampel H, Tsolaki M, Minthon L, Frisoni GB, Froelich L, Nobili F, van der Flier W, Blennow K, Wolz R, Scheltens P, Visser PJ. 2013. Neurology. 80: 1124-1132 A1 Journal article (refereed), original research -
Prevention of Alzheimer's Disease: Moving backward through the lifespan
Solomon A, Kivipelto M, Soininen H. 2013. Journal of Alzheimer's disease. 33: S465-S469 A2 Review article, Literature review, Systematic review -
Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study
Hallikainen I, Hänninen T, Fraunberg M, Hongisto K, Välimäki T, Hiltunen A, Karppi P, Sivenius J, Soininen H, Koivisto AM. 2013. International psychogeriatrics. 25: 1335-1344 A1 Journal article (refereed), original research -
Protein aggregation and degradation mechanisms in neurodegenerative diseases
Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A. 2013. American journal of neurodegenerative disease. 2: 1-14 A2 Review article, Literature review, Systematic review -
Quantitative evaluation of disease progression in a longitudinal mild cognitive impairment cohort
Runtti H, Mattila J, van Gils M, Koikkalainen J, Soininen H. 2013. Journal of Alzheimer's disease. -: - A1 Journal article (refereed), original research -
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's Disease patients alter calcium homeostasis
Rubio-Moscardo Fanny, Seto-Salvia Nuria, Pera Marta, Bosch-Morato Monica, Plata Christina, Belbin Olivia, Gene Gemma, Dols-Icardo Oriol, Ingelsson Martin, Helisalmi Seppo, Soininen Hilkka, Hiltunen Mikko, Giedraitis Vilmantas, Lannfelt Lars, Frank Ana, Bullido Ma Jesus, Combarros Onofre, Sanchez-Juan Pascual et.al.. 2013. PLoS ONE. 8: e74203 A1 Journal article (refereed), original research -
Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults
Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. 2013. Experimental gerontology. 48: 1428-1435 A1 Journal article (refereed), original research -
Single-domain amnestic mild cognitive impairment identified by Cluster analysis predicts Alzheimer's Disease in the European Prospective DESCRIPA Study
Damian M, Hausner L, Jekel K, Richter M, Froelich L, Almkvist O, Boada M, Bullock R, De Deyn PP, Frisoni GB, Hampel H, Jones RW, Kehoe P, Lenoir H, Minthon L, Olde Rikkert MGM, Rodriguez G, Scheltens P, Soininen H, Luizaa Spiru et.al.. 2013. Dementia and geriatric cognitive disorders. 36: 1-19 A1 Journal article (refereed), original research -
Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 781-794 A1 Journal article (refereed), original research -
Targeting ubiquilin-1 in Alzheimer's disease
Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KMA, Tanzi RE, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 795-810 A2 Review article, Literature review, Systematic review -
The Finnish Geriatric intervention study to prevent cognitive impairment and disability (FINGER): Study design and progress
Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. 2013. Alzheimer's & dementia. 9: 657-665 A1 Journal article (refereed), original research -
The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease
Antila K, Lötjönen J, Thurfjell L, Laine J, Massimini M, Rueckert D, Zubarev RA, Oresic M, van Gils M, Mattila J, Hviid Simonsen A, Waldemar G, Soininen H. 2013. Interface focus. 6 April 2013 vol. 3: 20120072 A1 Journal article (refereed), original research -
The association between APOE epsilon4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA study
Vermeiren APA, Bosma H, Visser P-J, Zeegers MP, Graff C, Ewers M, Frisoni GB, Frölich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili FM, Olde Rikkert M, Rigaud A-S, Scheltens P, Soininen H, Spiru L, Tsolaki M, Wahlund L-O et.al.. 2013. Journal of Alzheimer's disease. 35: 241-246 A1 Journal article (refereed), original research -
Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells
Viswanathan J, Haapasalo A, Kurkinen KMA, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Biochemistry. 52: 3899-3912 A1 Journal article (refereed), original research -
Validity of dementia and Alzheimer disease diagnoses in Finnish national registers
Solomon A, Ngandu T, Soininen H, Hallikainen M, Kivipelto M, Laatikainen T. 2013. Alzheimer's & dementia. Epub: 1-7 A1 Journal article (refereed), original research -
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment
Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H et.al.. 2013. Molecular psychiatry. -: 1-7 A1 Journal article (refereed), original research -
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. Journal of neurology neurosurgery and psychiatry. 83: 1119-1124 A1 Journal article (refereed), original research -
Alzheimer's Disease
Pihlajamäki M, Soininen H. Teoksessa: Bartsch T(toim.) , 2012. The Clinical Neurobiology of the Hippocampus. s. 223-244. Oxford University Press A3 Book section, Chapters in research books -
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation
Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, Pritchard M, Lord K, Martin BM, Craig D, Todd S, McGuinness B, Hollingworth P, Harold D, Kloszewska I, Soininen H, Mecocci P, Velas B, Gill M, Lawlor B, Rubinsztein DC, Brayne C, Passmore PA, Williams J, Lovestone S, Powell JF. 2012. Neurobiology of aging. 33: 1843.e9-1843.e17 A1 Journal article (refereed), original research -
Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
Greco I, Day N, Riddoch-Contreras J, Reed J, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Spenger C, Mecocci P, Wahlund L-O, Simmons A, Barnes J, Lovestone S. 2012. Journal of translational medicine. 10: 217 A1 Journal article (refereed), original research -
Alzheimerin taudin perustutkimuksesta uusiin lääkehoitoihin [with English Summary: From basic research towards novel therapies in Alzheimer's disease]
Hiltunen Mikko, Hallikainen Merja, Haapasalo Annakaisa, Soininen Hilkka. 2012. Dosis. 28: 25-31 A2 Review article, Literature review, Systematic review -
Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment
Ramakers IHGB, Verhey FRJ, Scheltens P, Hampel H, Soininen H, Aalten P, Olde Rikkert M, Verbeek MM, Spiru L, Blennow K, Trojanowski JQ, Shaw LM, Visser PJ. 2012. Psychological medicine. -: 1-10 A1 Journal article (refereed), original research -
Application of the PredictAD software tool to predict progression in patients with mild cognitive impairment
Simonsen AH, Mattila J, Hejl A-M, Frederiksen KS, Herukka S-K, Hallikainen M, van Gils M, Lötjönen J, Soininen H, Waldemar G. 2012. Dementia and geriatric cognitive disorders. 34: 344-350 A1 Journal article (refereed), original research -
Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
Hooshmand B, Solomon A, Kåreholt I, Rusanen M, Hänninen T, Leivistä J, Winblad B, Laatikainen T, Soininen H, Kivipelto M. 2012. Journal of internal medicine. 271: 204-212 A1 Journal article (refereed), original research -
Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
Sarajärvi Timo, Lipsanen Anu, Mäkinen Petra, Peräniemi Sirpa, Soininen Hilkka, Haapasalo Annakaisa, Jolkkonen Jukka, Hiltunen Mikko. 2012. Journal of cellular and molecular medicine. 16: 2754-2767 A1 Journal article (refereed), original research -
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology. 78: 1568-1575 A1 Journal article (refereed), original research -
Cognitive and neuropsychiatric symptom differences in early stages of Alzheimer's Disease: Kuopio ALSOVA Study
Hallikainen I, Koivisto AM, Paajanen T, Hiltunen A, Karppi P, Vanhanen M, Välimäki T, Herukka S-K, Soininen H, Hänninen T. 2012. Dementia and geriatric cognitive disorders. 2: 209-218 A1 Journal article (refereed), original research -
Combination of biomarkers: PET [18F]Flutemetamol imaging and structural MRI in Dementia and mild cognitive impairment
Thurfjell L, Lötjönen J, Lundqvist R, Koikkalainen J, Soininen H, Waldemar G, Brooks DJ, Vandenberghe R. 2012. Neurodegenerative diseases. 10: 246-249 A1 Journal article (refereed), original research -
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Journal of cellular and molecular medicine. 16: 1206-1222 A1 Journal article (refereed), original research -
Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von Und Zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. 2012. Neurodegenerative diseases. 10: 166-169 A1 Journal article (refereed), original research -
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's Disease Dementia
Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka S-K, Steinacker P, Tawfik S, Tumani H, von Arnim CSF, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M. 2012. PLoS ONE. 7: e48783 A1 Journal article (refereed), original research -
Education increases reserve against Alzheimer's disease - evidence from structural MRI analysis
Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund L-O, Aitken A, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H. 2012. Neuroradiology. 54: 929-938 A1 Journal article (refereed), original research -
Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer's Disease
Dubois B, Zaim M, Touchon J, Vellas B, Robert P, Murphy MF, Pujadas-Navines F, Rainer M, Soininen H, Riordan HJ, Kanony-Truc C. 2012. Journal of Alzheimer's disease. 29: 527-535 A1 Journal article (refereed), original research -
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Progress in neurobiology. 96: 87-95 A1 Journal article (refereed), original research -
Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD
Spulber G, Niskanen E, MacDonald S, Kivipelto M, Ferreira Padilla D, Julkunen V, Hallikainen M, Vanninen R, Wahlund L-O, Soininen H. 2012. Current alzheimer research. 9: 516-524 A1 Journal article (refereed), original research -
Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease
Whitehead D, Tunnard C, Hurt C, Wahlund LO, Mecocci P, Tsolaki M, Vellas B, Spenger C, Kloszewska I, Soininen H, Cromb D, Lovestone S, Simmons A. 2012. International psychogeriatrics. 24: 99-107 A1 Journal article (refereed), original research -
Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease
Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Journal of Alzheimer's disease. 28: 553-559 A1 Journal article (refereed), original research -
Genetics of Alzheimer's disease
Viswanathan J, Soininen H, Hiltunen M. Teoksessa: Gauthier S, Rosa-Neto P(toim.) , 2012. Advances in Alzheimer's Disease Management. s. 2-9. A3 Book section, Chapters in research books -
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C et al.. 2012. Molecular psychiatry. -: - A1 Journal article (refereed), original research -
Hippocampal atrophy in Alzheimer's disease
Soininen H, Liu Y, Rueckert D, Lötjönen J. 2012. Neurodegenerative disease management. 2: 197-209 A2 Review article, Literature review, Systematic review -
Hyperphosphorylated tau in young and middle-aged subjects
Elobeid A, Soininen H, Alafuzoff I. 2012. Acta neuropathologica. 123: 97-104 A1 Journal article (refereed), original research -
Identification of cis-regulatory variation influencing protein abundance levels in human plasma
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S, Dobson R. 2012. Human molecular genetics. 21: 3719-3726 A1 Journal article (refereed), original research -
Improved classification of Alzheimer's Disease data via removal of nuisance variability
Koikkalainen J, Pölönen H, Mattila J, van Gils M, Soininen H, Lötjönen J. 2012. PLoS ONE. 7: e31112 A1 Journal article (refereed), original research -
Injury markers predict time to dementia in subjects with MCI and amyloid pathology
van Rossum IA, Bos SJB, Burns L, Knol DL, Scheltens P, Soininen H, Wahlund L-O, Hampel H, Tsolaki M, Minthon L, L'Italien G, van der Flier WM, Teunissen CE, Blennow K, Barkhof F, Rueckert D, Wolz R, Verhey F, Visser PJ. 2012. Neurology. 79: 1809-1816 A1 Journal article (refereed), original research -
Midlife Vascular Risk Factors and Alzheimer's Disease: Evidence from Epidemiological Studies
Tolppanen AM, Solomon A, Soininen H, Kivipelto M. 2012. Journal of Alzheimer's disease. 32: 531-40 A2 Review article, Literature review, Systematic review -
Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: A population-based study
Wallin K, Solomon A, Kåreholt I, Tuomilehto J, Soininen H, Kivipelto M. 2012. Journal of Alzheimer's disease. 31: 669-676 A1 Journal article (refereed), original research -
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses
Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Journal of nutrition health and aging. 16: 631-635 A1 Journal article (refereed), original research -
Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's Disease blood
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A, on behalf of the AddNeuroMed Consortium. 2012. Journal of Alzheimer's disease. 30: 685-710 A1 Journal article (refereed), original research -
Optimizing the diagnosis of early Alzheimer's Disease in mild cognitive impairment subjects
Mattila J, Soininen H, Koikkalainen J, Rueckert D, Wolz R, Waldemar G, Lötjönen J. 2012. Journal of Alzheimer's disease. 32: 969-979 A1 Journal article (refereed), original research -
Plasma based markers of [11C] PiB-PET brain amyloid burden
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R. 2012. PLoS ONE. 7: e44260 A1 Journal article (refereed), original research -
Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature
Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. 2012. Neuropathology and applied neurobiology. 38: 72-86 A1 Journal article (refereed), original research -
Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer Disease
Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G, Colby S, Rollin L, Dockens R, Pachai C, Portelius E, Andreasson U, Blennow K, Soares H, Albright C, Feldman HH, Berman RM. 2012. Archives of neurology. 69: 1430-1440 A1 Journal article (refereed), original research -
Sensorimotor, visual, and auditory cortical atrophy in Unverricht-Lundborg Disease mapped with cortical thickness analysis
Koskenkorva P, Niskanen E, Hyppönen J, Könönen M, Mervaala E, Soininen H, Kälviäinen R, Vanninen R. 2012. American journal of neuroradiology. 33: 878-883 A1 Journal article (refereed), original research -
Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry
Munoz-Ruiz MA, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka S-K, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H. 2012. PLoS ONE. 7: e52531 A1 Journal article (refereed), original research -
TREM2 Variants in Alzheimer's Disease
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JSK, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert J-C, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St. George-Hyslop P, Singleton A, Hardy J, for the Alzheimer Genetic Analysis Group, Soininen H.... 2012. The new england journal of medicine. -: 1-11 A1 Journal article (refereed), original research -
Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI
Vos S, van Rossum I, Burns L, Knol D, Scheltens P, Soininen H, Wahlund L-O, Hampel H, Tsolaki M, Minthon L, Handels R, Italien GL, van der Flier W, Aalten P, Teunissen C, Barkhof F, Blennow K, Wolz R, Rueckert D, Verhey F, Visser PJ. 2012. Neurobiology of aging. 33: 2272-2281 A1 Journal article (refereed), original research -
The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent
Jacobs HIL, Visser PJ, Van Boxtel MPJ, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund L-O, Minthon L, Frölich L, Hampel H, Soininen H, van de Pol L, Scheltens P, Tan FES, Jolles J, Verhey FRJ. 2012. Neurobiology of aging. 33: 201.e1-201.e8 A1 Journal article (refereed), original research -
Tocopherols and tocotrienols plasma levels are associated with cognitive impairment
Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P. 2012. Neurobiology of aging. 33: 2282-2290 A1 Journal article (refereed), original research -
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions
Hartikainen PH, Pikkarainen M, Hänninen T, Soininen H, Alafuzoff I. 2012. Neuropathology. 32: 60-68 A1 Journal article (refereed), original research -
Voiko muistisairauksia ehkäistä?
Kivipelto M, Ngandu T, Soininen H, Laatikainen T. Teoksessa: Reivinen J, Vähäkylä L(toim.) , 2012. Kansan terveys, yksilön hyvinvointi. s. 91-107. Gaudeamus Oy D2 Article in a professional book (incl. an introduction by the editor) -
iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia
Lehnert S, Jesse S, Rist W, Steinacker P, Soininen H, Herukka S-K, Tumani H, Lenter M, Oeckl P, Ferger B, Hengerer B, Otto M. 2012. Experimental neurology. 234: 499-505 A1 Journal article (refereed), original research -
A Disease State Fingerprint for Evaluation of Alzheimer's Disease
Mattila J, Koikkalainen J, Virkki A, Simonsen A, van Gils M, Waldemar G, Soininen H, Lötjönen J. 2011. Journal of Alzheimer's disease. 27: 163-176 A1 Journal article (refereed), original research -
AMP-activated protein kinase: a potential player in Alzheimer's disease
Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of neurochemistry. 118: 460-474 A1 Journal article (refereed), original research -
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fievet N, Brouwers N, Bettens K, Arosio B, Coto E, Del Zompo M, Mateo I, Epelbaum J, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Valdivieso F, Vepsäläinen S et al.. 2011. Molecular psychiatry. 16: 903-907 A1 Journal article (refereed), original research -
AddNeuroMed and ADNI: Similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America
Westman E, Simmons A, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Weiner MW, Lovestone S, Spenger C, Wahlund L-O. 2011. Neuroimage. 58: 818-828 A1 Journal article (refereed), original research -
Age-related macular degeneration (AMD): Alzheimer's Disease in the eye
Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of Alzheimer's disease. 24: 615-631 A2 Review article, Literature review, Systematic review -
Alzheimer's Disease and mild cognitive impairment are associated with elevated levels of isoaspartyl residues in blood plasma proteins
Yang H, Lyutvinskiy Y, Soininen H, Zubarev RA. 2011. Journal of Alzheimer's disease. 27: 113-118 A1 Journal article (refereed), original research -
Alzheimer's disese-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
Viswanathan Jayashree, Haapasalo Annakaisa, Böttcher Claudia, Miettinen Riitta, Kurkinen Kaisa MA, Lu Alice, Thomas Anne, Maynard Christa J, Romano Donna, Hyman Bradley T, Berezovska Oksana, Bertram Lars, Soininen Hilkka, Dantuma Nico P, Tanzi RE, Hiltunen Mikko. 2011. Traffic. 12: 330-348 A1 Journal article (refereed), original research -
Apathy and cortical atrophy in Alzheimer's disease
Tunnard C, Whitehead D, Hurt C, Wahlund LO, Mecocci P, Tsolaki M, Vellas B, Spenger C, Kloszewska I, Soininen H, Lovestone S, Simmons A. 2011. International journal of geriatric psychiatry. 26: 741-748 A1 Journal article (refereed), original research -
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. European journal of neuroscience. 34: 3-11 A2 Review article, Literature review, Systematic review -
Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment
Costafreda Sergi G, Dinov Ivo D, Tu Zhuowen, Shi Yonggang, Liu Cheng-Yi, Kloszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Wahlund Lars-Olof, Spenger Christian, Toga Arthur W, Lovestone Simon, Simmons Andrew. 2011. Neuroimage. 56: 212-219 A1 Journal article (refereed), original research -
CERAD-neuropsychological battery in screening mild Alzheimer's disease
Sotaniemi M, Pulliainen V, Hokkanen L, Pirttilä T, Hallikainen I, Soininen H, Hänninen T. 2011. Acta neurologica scandinavica. doi:10.1111/j.1439-0272.2010.01459.: 1-8 A1 Journal article (refereed), original research -
Changes in vascular risk factors from midlife to late life and white matter lesions: A 20-year follow-up study
Vuorinen Miika, Solomon Alina, Rovio Suvi, Nieminen Lasse, Kåreholt Ingemar, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. 2011. Dementia and geriatric cognitive disorders. 31: 119-125 A1 Journal article (refereed), original research -
Characterization of a novel transgenic rat carrying human tau with mutation P301L
Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen M-L, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H. 2011. Neurobiology of aging. 32: 2314-2315 A1 Journal article (refereed), original research -
Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups - The AddNeuroMed study
Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H. 2011. Neurobiology of aging. 32: 1198-1206 A1 Journal article (refereed), original research -
Combinatorial markers of mild cognitive impairment conversion to Alzheimer's Disease - cytokines and MRI measures together predict disease progression
Furney SJ, Kronenberg D, Simmons A, Guntert A, Dobson RJ, Proitsi P, Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lovestone S. 2011. Journal of Alzheimer's disease. 26: 395-405 A1 Journal article (refereed), original research -
Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's Disease
Julkunen P, Jauhiainen AM, Könönen M, Pääkkönen A, Karhu J, Soininen H. 2011. International journal of alzheimers disease. 2011: 1-9 A1 Journal article (refereed), original research -
Common variants at ABCA7,MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J et al.. 2011. Nature genetics. 43: 429-435 A2 Review article, Literature review, Systematic review -
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking
Sarajärvi Timo, Tuusa Jussi T, Haapasalo Annakaisa, Lackman Jarkko T, Sormunen Raija, Helisalmi Seppo, Roehr Johannes T, Parrado Antonio R, Mäkinen Petra, Bertram Lars, Soininen Hilkka, Tanzi Rudolph E, Petäjä-Repo Ulla E, Hiltunen Mikko. 2011. Molecular and cellular biology. 31: 2326-2340 A1 Journal article (refereed), original research -
Deep sequencing of the nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease
Lupton Michell K, Proitsi Petroula, Danillidou Makrina, Tsolaki Magda, Hamilton Gillian, Wroe Richard, Pritchard Megan, Lord Kathryn, Martin Belinda M, Kloszewska Iwona, Soininen Hilkka, Mecocci Patrizia, Vellas Bruno, Harold Denise, Hollingworth Paul, Lovestone Simon, Powell John F. 2011. PLoS ONE. 6: e17298 A1 Journal article (refereed), original research -
Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment
Liu Y, Spulber G, Lehtimäki KK, Könönen M, Hallikainen I, Gröhn H, Kivipelto M, Hallikainen M, Vanninen R, Soininen H. 2011. Neurobiology of aging. 32: 1558-1571 A1 Journal article (refereed), original research -
Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar Ataxia as assessed by p62/Sequestosome immunohistochemistry
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I. 2011. Cerebellum. 10: 720-731 A1 Journal article (refereed), original research -
Do instrumental activities of daily living predict dementia at 1- and 2-year follow-up? Findings from the development of screening guidelines and diagnostic criteria for predementia Alzheimer's Disease Study
Sikkes SAM, Visser PJ, Knol DL, de Lange-de-Klerk ESM, Tsolaki M, Frisoni GB, Nobili F, Spiru L, Rigaud AS, Frölich L, Olde Rikkert M, Soininen H, Touchon J, Wilcock G, Boada M, Hampel H, Bullock R, Vellas B, Pijnenburg YAL, Scheltens P, Verhey FR, Uitdehaag BMJ. 2011. Journal of the american geriatrics society. 59: 2273-2281 A1 Journal article (refereed), original research -
Effect of cholinergic stimulation in early Alzheimer's Disease - Functional imaging during a recognition memory task
Miettinen PS, Pihlajamäki M, Jauhiainen AM, Tarkka IM, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. 2011. Current alzheimer research. 8: 753-764 A1 Journal article (refereed), original research -
Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease
Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Progress in neurobiology. 96: 87-95 A1 Journal article (refereed), original research -
Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations
Lambert J, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, Tognoni G, Fievet N, Boland A, Arosio B, Coto E, Del Zompo M, Mateo I, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri F, Delepine M et al.. 2011. Neurobiology of aging. 32: 756.e11-756.e15 A1 Journal article (refereed), original research -
Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease
Lötjönen Jyrki, Wolz Robin, Koikkalainen Juha, Julkunen Valtteri, Thurfjell Lennart, Lundqvist Roger, Waldemar Gunhild, Soininen Hilkka, Rueckert Daniel. 2011. Neuroimage. 56: 185-196 A1 Journal article (refereed), original research -
Improved generation of probabilistic atlases for the expectation maximization classification
Lötjönen Jyrki, Wolz Robin, Koikkalainen Juha, Thurfjell Lennart, Lundqvist Roger, Waldemard Gunhild, Soininen Hilkka, Rueckert Daniel. Teoksessa: Wright S, Pan X, Liebling M (Eds)(toim.) , 2011. Proceedings - International Symposium on Biomedical Imaging. s. 1839-1842. IEEE A4 Conference proceedings -
Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation
Haapasalo A, Viswanathan J, Kurkinen KMA, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. 2011. Communicative & integrative biology. 4: 428-432 A1 Journal article (refereed), original research -
Longitudinal changes of CSF biomarkers in Alzheimer's Disease
Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka S-K. 2011. Journal of Alzheimer's disease. 25: 583-594 A1 Journal article (refereed), original research -
Metabolome in progression to Alzheimer's disease
Oresic M, Hyötyläinen T, Herukka S-K, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H. 2011. Translational psychiatry. 1: e57 A1 Journal article (refereed), original research -
Midlife healthy-diet index and late-life dementia and Alzheimer's disease
Eskelinen Marjo, Ngandu Tiia, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. 2011. Dementia and geriatric cognitive disorders. 1: 103-112 A1 Journal article (refereed), original research -
Multi-method analysis of MRI images in early diagnostics of Alzheimer's Disease
Wolz R, Julkunen V, Koikkalainen J, Niskanen E, Zhang DP, Rueckert D, Soininen H, Lötjönen J. 2011. PLoS ONE. 6: e25446 A1 Journal article (refereed), original research -
Multi-template tensor-based morphometry: Application to analysis of Alzheimer's disease
Koikkalainen Juha, Lötjönen Jyrki, Thurfjell Lennart, Rueckert Daniel, Waldemar Gunhild, Soininen Hilkka. 2011. Neuroimage. 56: 1134-1144 A1 Journal article (refereed), original research -
Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls
Westman Eric, Simmons Andrew, Zhang Yi, Muehlboeck J-Sebastian, Tunnard Catherine, Liu Yawu, Collins Louis, Evans Alan, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Soininen Hilkka, Lovestone Simon, Spenger Christian, Wahlund Lars-Olof. 2011. Neuroimage. 54: 1178-1187 A1 Journal article (refereed), original research -
New insights into Alzheimer's disease progression: A combined TMS and structural MRI study
Niskanen Eini, Könönen Mervi, Määttä Sara, Hallikainen Merja, Kivipelto Miia, Casarotto Silvia, Massimini Marcello, Vanninen Ritva, Mervaala Esa, Karhu Jari, Soininen Hilkka. 2011. PLoS ONE. 6: e26113 A1 Journal article (refereed), original research -
No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease
Turunen Mari, Vepsäläinen Saila, Mäkinen Petra, Helisalmi Seppo, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2011. Neurobiology of aging. 32: 547.e7-547.e9 A1 Journal article (refereed), original research -
Plasma biomarkers of brain atrophy in Alzheimer's Disease
Thambisetty M, Simmons A, Hye A, Campbell J, Westman E, Zhang Y, Wahlund L-O, Kinsey A, Causevic M, Killick R, Kloszweska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lovestone S. 2011. PLoS ONE. 6: e28527 A1 Journal article (refereed), original research -
Regional differences in effects of APOE allele4 on cognitive impairment in non-demented subjects
Nordberg J, Graff C, Almkvist O, Ewers M, Frisoni GB, Fröhlich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili F, Olde Rikkert M, Rigaud A-S, Scheltens P, Soininen H, Spiru L, Tsolari M, Wahlund L-O, Vellas B, Wilcock G, Elias-Sonnenschein LS, Verhey FRJ, Visser PJ. 2011. Dementia and geriatric cognitive disorders. 32: 135-142 A1 Journal article (refereed), original research -
Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's Disease
Westman E, Cavallin L, Muehlboeck J-S, Zhang Y, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Simmons A, Wahlund L-O. 2011. PLoS ONE. 6: e22506 A1 Journal article (refereed), original research -
Software tool for improved prediction of Alzheimer's Disease
Soininen H, Mattila J, Koikkalainen J, van Gils M, Hviid Simonsen A, Waldemar G, Rueckert D, Thurfjell L, Lötjönen J. 2011. Neurodegenerative diseases. doi:10.1159/000332600: www.karger.com/ndd A1 Journal article (refereed), original research -
Structure and function of medial temporal and posteromedial cortices in early Alzheimer's disease
Miettinen PS, Pihlajamäki M, Jauhiainen AM, Niskanen E, Hänninen T, Vanninen R, Soininen H. 2011. European journal of neuroscience. 34: 320-330 A1 Journal article (refereed), original research -
Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol
Boccardi M, Ganzola R, Bocchetta M, Pievani M, Redolfi A, Bartzokis G, Camicioli R, Csernansky JG, de Leon MJ, de Toledo-Morrell L, Killiany RJ, Lehericy S, Pantel J, Pruessner JC, Soininen H, Watson C, Duchesne S, Jack Jr CR, Frisoni GB. 2011. Journal of Alzheimer's disease. 26: 61-75 A2 Review article, Literature review, Systematic review -
Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. Negative results
Tolppanen AM, Helisalmi S, Hiltunen M, Kolehmainen M, Schwab U, Pirttilä T, Pulkkinen L, Uusitupa M & Soininen H.. 2011. Neurobiology of aging. 32: 546.e7-546.e9 A1 Journal article (refereed), original research -
The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months
Simmons Andrew, Westman Eric, Muehlboeck Sebastian, Mecocci Patrizia, Vellas Bruno, Tsolaki Magda, Kloszewska Iwona, Wahlund Lars-Olof, Soininen Hilkka, Lovestone Simon, Evans Alan, Spenger Christian. 2011. International journal of geriatric psychiatry. 26: 75-82 A1 Journal article (refereed), original research -
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
Mattson N, Andreasson U, Persson S, Arai H, Dev Batish S, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlbors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka S-K. 2011. Alzheimer's & dementia. 7: 386-395 A1 Journal article (refereed), original research -
Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging
Casarotto S, Määttä S, Herukka SK, Pigorini A, Napolitani M, Gosseries O, Niskanen E, Könönen M, Mervaala E, Rosanova M, Soininen H, Massimini M. 2011. Neuroreport. 22: 592-597 A1 Journal article (refereed), original research -
Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland
Bell J Simon, Lönnroos Eija, Koivisto Anne M, Lavikainen Piia, Laitinen Marja-Liisa, Soininen Hilkka, Hartikainen Sirpa. 2011. Journal of Alzheimer's disease. 26: 231-237 A1 Journal article (refereed), original research -
Uusia Alzheimerin taudin lääkkeitä etsimässä
Soininen H. 2011. Duodecim. 127: 2345-2347 A1 Journal article (refereed), original research -
APOE epsilon-2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes
Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J et al. 2010. Dementia and geriatric cognitive disorders. 30: 229-237 A1 Journal article (refereed), original research -
Amyloid and Tau proteins in cortical brain biopsy and Alzheimer's Disease
Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J & Alafuzoff I. 2010. Annals of neurology. 68: 446-453 A1 Journal article (refereed), original research -
An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M. 2010. Journal of Alzheimer's disease. 21: 763-767 A1 Journal article (refereed), original research -
Analysis of human Tau in cerbrospinal fluid
Hanisch K, Soininen H, Alafuzoff I & Hoffman R. 2010. Journal of proteome research. 9: 1476-1482 A1 Journal article (refereed), original research -
Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease
Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M et al. 2010. Neurobiology of aging. 31: 1375-1385 A1 Journal article (refereed), original research -
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Guntert A et al. 2010. Archives of general psychiatry. 67: 739-748 A1 Journal article (refereed), original research -
Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation
Martikainen P, Pikkarainen M, Pöntynen K, Hiltunen M, Lehtovirta M, Tuisku S, Soininen H & Alafuzoff I. 2010. Neuropathology and applied neurobiology. 36: 41-54 A1 Journal article (refereed), original research -
CALHM1 P86L polymorphism does not alter amyloid-beeta or tau in cerebrospinal fluid
Giedraitis V, Glaser A, Sarajärvi T, Brundin RM, Degerman Gunnarsson M, Schjeide BM, Tanzi RE, Helisalmi S et al. 2010. Neuroscience letters. 469: 265-267 A1 Journal article (refereed), original research -
CERAD Neuropsychological battery total score in multinational mild cognitive impairment and control populations: The AddNeuroMed Study
Paajanen T, Hänninen T, Tunnard C, Mecocci P, Sobow T, Tsolaki M, Vellas B, Lovestone S & Soininen H. 2010. Journal of Alzheimer's disease. 22: 1089-1097 A1 Journal article (refereed), original research -
Cluster analysis and decision trees of MR imaging in patients suffering Alzheimer's
Hamou A, Bauer M, Lewden B, Simmons A, Zhang Y, Wahlund LO, Tunnard C, Kloszewska I, Mecozzi, Soininen H et al. 2010. Trends in Practical Applications of Agents and Multiagent Systems. 71. Springer-Verlag C1 Book -
Consensus statement on dementia education and training in Europe
Tsolaki M, Papaliagkas V, Anogianakis G, Bernabei R, Emre M, Frolich L, Visser PJ, Michel JP, Pirttilä T, Olde Rikkert M, Soininen H et al. 2010. Journal of nutrition health and aging. 14: 131-135 A1 Journal article (refereed), original research -
Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's Diseaes patients: A longitudinal study
Julkunen V, Niskanen E, Koikkalainen J, Herukka SK, Pihlajamäki M, Hallikainen H, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R & Soininen H. 2010. Journal of Alzheimer's disease. 21: 1141-1151 A1 Journal article (refereed), original research -
Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's Disease
Bronzova J, Sampaio C, Hauser RA, Lang AE, Rascol O, Theeuwes A, van de Witte SV, van Scharrenburg G on behalf of the Bruegel Study Group. 2010. Movement disorders. 25: 738-746 A1 Journal article (refereed), original research -
Effect of APOE epsilon4 allele on cortical thicknesses and volumes: The AddNeuroMed Study
Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J et al. 2010. Journal of Alzheimer's disease. 21: 947-966 A1 Journal article (refereed), original research -
Effects of cholinesterase inhibitors on the activities and protein levels of cholinesterases in the cerebrospinal fluid of patients with Alzheimer's disease: A review of recent clinical studies
Darreh-Shori T & Soininen H. 2010. Current alzheimer research. 7: 67-73 A1 Journal article (refereed), original research -
Fast and bobust multi-atlas segmentation of brain magnetic resonance images
Lötjönen JMP, Wolz R, Koikkalainen JR, Thurfjell L, Waldemar G, Soininen H & Rueckert D. 2010. Neuroimage. 49: 2352-2365 A1 Journal article (refereed), original research -
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease
Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I et al. 2010. Molecular psychiatry. doi:10.1038/mp.2010.123: 1-9 A1 Journal article (refereed), original research -
Homocysteine and holotranscobalamin and the risk of Alzheimer disease
Hooshmand B, Solomon A, Kåreholt I, Leivistä J, Rusanen M, Ahtiluoto S, Winblad B, Laatikainen T, Soininen H & Kivipelto M. 2010. Neurology. 75: 1408-1414 A1 Journal article (refereed), original research -
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Progress in neurobiology. 93: 99-110 A1 Journal article (refereed), original research -
Insight, cognition and quality of life in Alzheimer's disease
Hurt CS, Banerjee S, Tunnard C, Whitehead DL, Tsolaki M, Mecocci P, Kloszewska I & Soininen H et al. 2010. Journal of neurology neurosurgery and psychiatry. 81: 331-336 A1 Journal article (refereed), original research -
Lipid-Lowering Treatment Is Related to Decreased Risk of Dementia: A Population-Based Study (FINRISK)
Solomon A, Sippola R, Soininen H, Wolozin B, Tuomilehto J, Laatikainen T & Kivipelto M. 2010. Neurodegenerative diseases. 7: 180-182 A1 Journal article (refereed), original research -
Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: A population-based cardiovascular risk factors, aging and dementia study
Rusanen M, Rovio S, Ngandu T, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. 2010. Dementia and geriatric cognitive disorders. 30: 277-284 A1 Journal article (refereed), original research -
Muistisairaudet
Erkinjuntti T, Rinne J & Soininen H. 2010. . . WS Bookwell Oy C1 Book -
Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease
Karttunen K, Karppi P, Hiltunen A, Vanhanen M, Välimäki T, Martikainen J, Valtonen H, Sivenius J, Soininen H, Hartikainen S, Suhonen J & Pirttilä T; for the ALSOVA study group. 2010. International journal of geriatric psychiatry. 2011:26: 473-482 A1 Journal article (refereed), original research -
Plasma A-beta42 and A-beta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study
Seppälä TT, Herukka SK, Hänninen T, Tervo S, Hallikainen M, Soininen H & Pirttilä T. 2010. Journal of neurology neurosurgery and psychiatry. 81: 1123-1127 A1 Journal article (refereed), original research -
Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease
Oresic M, Lötjönen J & Soininen H. 2010. Genome medicine. 2: 2-5 B1 Non-refereed journal articles -
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
Lambert JC, Sleegers K, Gonzalez-Perez A, Ingelsson M, Beecham GW, Hiltunen M et al. 2010. Journal of Alzheimer's disease. 22: 247-255 A1 Journal article (refereed), original research -
The effect of midlife physical activity on structural brain changes in the elderly
Rovio S, Spulber G, Nieminen LJ, Niskanen E, Winblad B, Tuomilehto J, Nissinen A, Soininen H & Kivipelto M. 2010. Neurobiology of aging. 31: 1927-1936 A1 Journal article (refereed), original research -
Whole brain atrophy rate predicts progression from MCI to Alzheimer's disease
Spulber G, Niskanen E, MacDonald S, Smilovici O, Chen K, Reiman EM, Jauhiainen AM, Hallikainen M, Tervo S, Wahlund LO, Vanninen R, Kivipelto M, Soininen H. 2010. Neurobiology of aging. 31: 1601-1605 A1 Journal article (refereed), original research -
cNEUPRO: Novel biomarkers for neurodegenerative diseases
Spitzer P, Klafki HW, Blennow K, Buee L, Esselmann H, Herukka SK, Jimenez C, Klivenyi P, Lewczuk P, Maler JM et al. 2010. International journal of alzheimers disease. ID548145: 1-12 A2 Review article, Literature review, Systematic review -
AddNeuroMed - The European collaboration for the discovery of novel biomarkers for Alzheimer's disease
Lovestone S, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund L-O, Ward M, on behalf of the AddNeuroMed Consortium, Soininen H. 2009. Annals of the New York Academy of Sciences. 1180: 36-46 A1 Journal article (refereed), original research -
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population
Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M, Soininen H, Hiltunen M, Helisalmi S. 2009. American journal of medical genetics. Part B : neuropsychiatric genetics. 150B: 747-750 A1 Journal article (refereed), original research -
Association between mid-life marital status and cognitive function in later life: population based cohort study
Håkansson K, Rovio S, Helkala E-L, Vilska A-R, Windlad B, Soininen H, Nissinen A, Mohammed AH, Kivipelto M, Soininen H. 2009. BMJ. 339: A1 Journal article (refereed), original research -
Beta-amyloid deposition in brains of subjects with diabetes
Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H, Soininen H. 2009. Neuropathology and applied neurobiology. 1: 60-68 A1 Journal article (refereed), original research -
Cerebrospinal fluid {beta}-amyloid 42 and Tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
Tapiola T, Alafuzoff I, Herukka S-K, Parkkinen L, Hartikainen P, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2009. Archives of neurology. 66: 382-389 A1 Journal article (refereed), original research -
Combined risk effects of IDE and NEP gene variants on Alzheimer disease
Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M, Helisalmi S, Pirttilä T, Soininen H, Hiltunen M. 2009. Journal of neurology neurosurgery and psychiatry. 80: 1268-1270 A1 Journal article (refereed), original research -
Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease
Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, Hallikainen M, Kivipelto M, Tervo S, Vanninen R, Evans A, Soininen H, Soininen H. 2009. Dementia and geriatric cognitive disorders. 28: 404-412 A1 Journal article (refereed), original research -
Different cholinesterase inhibitor effects on CSF cholines Alzheimer patients
Nordberg A, Darreh-Shori T, Peskind E, Soininen H, Mousavi M, Eagle G, Lane R, Soininen H. 2009. Current alzheimer research. 6: 4-14 A1 Journal article (refereed), original research -
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment
Jauhiainen AM, Pihlajamäki M, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H, Soininen H. 2009. Hippocampus. 19: 166-175 A1 Journal article (refereed), original research -
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis
Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M, Soininen H, Hiltunen M. 2009. Journal of biological chemistry. 284: 34433-34443 A1 Journal article (refereed), original research -
Effects of ubiquillin 1 on the unfolded protein response
Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE, Hiltunen M, Soininen H. 2009. Journal of molecular neuroscience. 38: 19-30 A1 Journal article (refereed), original research -
Flanking markers of cyntation C (CST3) gene do not show association with Alzheimer's disease
Helisalmi S, Väkevä A, Hiltunen M, Soininen H, Soininen H, Helisalmi S. 2009. Dementia and geriatric cognitive disorders. 27: 318-321 A1 Journal article (refereed), original research -
Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus
Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J, Hiltunen M, Sivenius J, Soininen H. 2009. Neurobiology of disease. 35: 103-113 A1 Journal article (refereed), original research -
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Lambert JC, Heath S, Even G..., Hiltunen M, Combarros O..., Helisalmi S, Porcellini E..., Licastro F, Soininen H, Ritchie K..., Amouyel P, Hiltunen M, Helisalmi S, Soininen H. 2009. Nature genetics. 41: 1047-1048 A1 Journal article (refereed), original research -
Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease
Singer D, Soininen H, Alafuzoff I, Hoffmann R, Soininen H. 2009. . 395: 2263-2267 A1 Journal article (refereed), original research -
MRI measures of Alzheimer's disease and the AddNeuroMed study
Simmons A, Westman E, Muehlboeck S, Meccoci P, Vellas B, Tsolaki M, Kloszewska I, Wahlund L-O, Soininen H, Lovestone S, Evans A, Spenger C, for the AddNeuroMed Consortium, Soininen H. 2009. Annals of the New York Academy of Sciences. 1180: 47-55 A1 Journal article (refereed), original research -
Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study
Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M, Soininen H. 2009. Journal of Alzheimer's disease. 16: 85-91 A1 Journal article (refereed), original research -
Muistihäiriöpotilaan neurologisten löydösten diagnostiset vihjeet
Soininen H, Soininen H. 2009. Lääkärilehti. 64: 4049-4053 A2 Review article, Literature review, Systematic review -
Olfactory identification in non-demented elderly population and mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test
Laakso MP, Tervo S, Hänninen T, Vanhanen M, Hallikainen M, Soininen H, Soininen H, Laakso MP. 2009. Journal of neural transmission. 116: 891-895 A1 Journal article (refereed), original research -
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease
Solomon A, Leoni V, Kivipelto M, Besga A, Öksengård AR, Julin P, Svensson L, Wahlund L-O, Andreasen N, Winbland B, Soininen H, Björkhem I, Soininen H. 2009. Neuroscience letters. : 89-93 A1 Journal article (refereed), original research -
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study
Visser PJ, Verhey F, Knol DL, Scheltens P, Wahlund L-O, Freud-Levi Y, Tsolaki M, Minthon L, Wallin ÅK, Hampel H, Burger K, Pirttila T, Soininen H, Rikkert MO, Verbeek MM, Spiru L, Blennow K, Pirttilä T, Soininen H. 2009. The Lancet Neurology. 8: 619-627 A1 Journal article (refereed), original research -
Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment
Ferris S, Nordberg A, Soininen H, Darreh-Shori T, Lane R, Soininen H. 2009. Pharmacogenetics and genomics. : 635-646 A1 Journal article (refereed), original research -
Safety of lumbar puncture procedures in patients with Alzheimer's disease
Peskind E, Nordberg A, Darreh-Shori T, Soininen H, Soininen H. 2009. Current alzheimer research. 6: 290-292 A1 Journal article (refereed), original research -
Serum total cholesterol, statins and cognition in non-demented elderly
Solomon A, Kåreholt I, Ngandu T, Wolozin B, Macdonald SW, Winbland B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M, Soininen H. 2009. Neurobiology of aging. 30: 1006-1009 A1 Journal article (refereed), original research -
Structural and functional MRI in mild cognitive impairment
Pihlajamäki M, Jauhiainen AM, Soininen H, Soininen H. 2009. Current alzheimer research. 6: 179-185 A1 Journal article (refereed), original research -
White matter hyperintensities and medial temporal lobe atrophy in clincal subtypes of mild cognitive impairment: the DESCRIPA study
van de Pol LA, Verhey F, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund L-O, Minthon L, Frölich L, Hampel H, Soininen H, Knol DL, Barkhof F, Scheltens P, Visser PJ, Soininen H. 2009. Journal of neurology neurosurgery and psychiatry. 80: 1069-1074 A1 Journal article (refereed), original research -
A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease
Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. Biochemical and biophysical research communications. 375: 356-361 A1 Journal article (refereed), original research -
Apolipoprotein E epsilon4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study
Hämäläinen A, Grau-Olivares M, Tervo S, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala E-L, Nissinen A, Vanninen RL, Soininen H, Hallikainen M, Soininen H. 2008. Neurodegenerative diseases. 5: 186-189 A1 Journal article (refereed), original research -
Apolipoprotein E epsilon4 magnifiles lifestyle risks for dementia: a population-based study
Kivipelto M, Rovio S, Ngandu T, Kåreholt I, Eskelinen M, Wiblad B, Hachinski V, Cedazo-Minguez A, Soininen H, Tuomilehto J, Nissinen A, Soininen H. 2008. Journal of cellular and molecular medicine. 12: 2762-2771 A1 Journal article (refereed), original research -
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11- labeled Pittsburgh compound B
Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne J, Pirttilä T, Soininen H. 2008. Archives of neurology. 65: 1304-1309 A1 Journal article (refereed), original research -
Brain anatomy of persistent violent offenders: more rather than less
Tiihonen J, Rossi R, Laakso MP, Hodgins S, Testa C, Perez J, Repo-Tiihonen E, Vaurio O, Soininen H, Aronen HJ, Könönen M, Thompson PM, Frisoni G, Könönen M, Soininen H. 2008. Psychiatry research: neuroimaging. 163: 201-212 A1 Journal article (refereed), original research -
CSF Abeeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy
Herukka S-K, Pennanen C, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2008. Journal of Alzheimer's disease. 14: 51-57 A1 Journal article (refereed), original research -
Coaccumulation of calcium and b-amyloid in the thalamus after transient middle cerebral artery occlusion in rats
Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J, Hiltunen M, Soininen H. 2008. Journal of cerebral blood flow and metabolism. 28: 263-268 A1 Journal article (refereed), original research -
Dementoivat sairaudet ja kognitiivinen prosessointi
Soininen H, Hänninen T, Soininen H. Teoksessa: Juntunen J et al(toim.) , 2008. Aivot ja ajattelu. Kliininen kognitiivinen neurotiede. s. 102-118. Recallmed A3 Book section, Chapters in research books -
Development of screening guidelines and clinical criteria for predementia Alzheimer's disease
Visser PJ, Verhey FRJ, Boada M, Bullock R, De Deyn PP, Frisoni GB, Frölich L, Hampel H, Jolles J, Jones R, Minthon L, Nobili F, Olde Rikkert M, Ousset P-J, Rigaud A-S, Scheltens P, Soininen H, Spiru L ..., Soininen H, DESCRIPA Study Group. 2008. Neuroepidemiology. 30: 254-265 A1 Journal article (refereed), original research -
Differential hypometabolism patterns according to mild cognitive impairment subtypes
Jauhiainen AM, Kangasmaa T, Rusanen M, Niskanen E, Tervo S, Kivipelto M, Vanninen RL, Kuikka JT, Soininen H, Soininen H. 2008. Dementia and geriatric cognitive disorders. 26: 490-498 A1 Journal article (refereed), original research -
Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study
Eskelinen MH, Ngandu T, Helkala EL, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M, Soininen H. 2008. International journal of geriatric psychiatry. 23: 741-747 A1 Journal article (refereed), original research -
Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease
Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Journal of neurology. 255: 668-673 A1 Journal article (refereed), original research -
Genetic study evaluating LDLR polymorphisms and Alzheimer's disease
Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Pirttilä T, Soininen H. 2008. Neurobiology of aging. 29: 848-855 A1 Journal article (refereed), original research -
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Neuroscience letters. 438: 216-220 A1 Journal article (refereed), original research -
Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease
Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H, Helisalmi S, Hiltunen M, Soininen H. 2008. Neuroscience letters. 441: 233-236 A1 Journal article (refereed), original research -
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease
Blom ES, Viswanathan J, Kilander L, Helisalmi S, Soininen H, Lannfelt L, Ingelsson M, Glaser A, Hiltunen M, Helisalmi S, Soininen H, Hiltunen M. 2008. European journal of human genetics. 16: 171-175 A1 Journal article (refereed), original research -
MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study
Tapiola T, Pennanen C, Tapiola M, Tervo S, Kivipelto M, Hänninen T, Pihlajamäki M, Laakso MP, Hallikainen M, Hämäläinen A, Vanhanen M, Helkala EL, Vanninen R, Nissinen A, Rossi R, Frisoni GB, Soininen H. 2008. Neurobiology of aging. 29: 31-38 A1 Journal article (refereed), original research -
Mixed brain pathologies in dementia: the BrainNet Europe consortium experience
Kovacs GG, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Capellari S, Ferrer I, Gelpi E, Kövari V, Kretzschmar H, Nagy Z, Parchi P, Seilhean D, Soininen H, Troakes C, Budka H, Soininen H. 2008. Dementia and geriatric cognitive disorders. 26: 343-350 A1 Journal article (refereed), original research -
Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: a pilot study
Julkunen P, Jauhiainen AM, Westerén-Punnonen S, Pirinen E, Soininen H, Könönen M, Pääkkönen A, Määttä S, Karhu J, Könönen M, Soininen H. 2008. Journal of neuroscience methods. 172: 270-276 A1 Journal article (refereed), original research -
No association between CALHM1 and Alzheimers's disease risk
Bertram L, Schjeide BMM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE, Hiltunen M, Soininen H. 2008. Cell -
PET amyloid ligand (11C)PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment
Koivunen J, Pirttilä T, Kemppainen N, Aalto S, Herukka S-K, Jauhiainen AM, Hänninen T, Hallikainen M, Någren K, Rinne JO, Soininen H, Pirttilä T, Soininen H. 2008. Dementia and geriatric cognitive disorders. 26: 378-383 A1 Journal article (refereed), original research -
Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease
Lane R, Feldman HH, Meyer J, He Y, Ferris SH, Nordberg A, Darreh-Shori T, Soininen H, Pirttilä T, Farlow MR, Sfikas N, Ballard C, Greig NG, Soininen H, Pirttilä T. 2008. Pharmacogenetics and genomics. 18: 289-298 A1 Journal article (refereed), original research -
Alcohol drinking and cognitive functions: findings from the cardiovascular risk factors aging and dementia (CAIDE) study
Ngandu T, Helkala E-L, Soininen H, Winblad B, Tuomilehto J, Nissinen A, Kivipelto M. 2007. Dementia and geriatric cognitive disorders. 23: 140-149 A1 Journal article (refereed), original research -
CSF Abeta42, tau and phosphorylated tau, APOE epsilon4 allele and MCI type in progressive MCI
Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T, Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T. 2007. Neurobiology of aging. 28: 507-514 A1 Journal article (refereed), original research -
Education and dementia: What lies behind the association?
Ngandu T, von Strauss E, Helkala E-L, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M, Soininen H. 2007. Neurology. 69: 1442-1450 A1 Journal article (refereed), original research -
Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy
Sakka P, Tsolaki M, Hort J, Hager K, Soininen H, Pousa SL, Li C, Schwam E, Soininen H. 2007. Current medical research and opinion. 23: 3153-3165 A1 Journal article (refereed), original research -
Increased fMRI responses during encoding in mild cognitive impairment
Hämäläinen A, Pihlajamäki M, Tanila H, Hänninen T, Niskanen E, Tervo S, Karjalainen PA, Vanninen RL, Soininen H, Soininen H, Tervo S. 2007. Neurobiology of aging. 28: 1889-1903 A1 Journal article (refereed), original research -
Insulin-degrading enzyme is genetically associated wirh Alzheimer's disease in the finnish population
Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M, Vepsäläinen S, Helisalmi S, Soininen H, Hiltunen M. 2007. Journal of medical genetics. 44: 606-608 A1 Journal article (refereed), original research -
Long-term efficacy and safety of celecoxib in Alzheimer¿s disease
Soininen H, West C, Robbins J, Niculescu L, Soininen H. 2007. Dementia and geriatric cognitive disorders. 23: 8-21 A1 Journal article (refereed), original research -
Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats
Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J, Soininen H. 2007. European journal of neuroscience. 26: 1845-1852 A1 Journal article (refereed), original research -
Serum cholesterol changes after midlife and late-life cognition. Twenty-one-year follow-up study
Solomon A, Kåreholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. 2007. Neurology. 68: 751-756 A1 Journal article (refereed), original research -
Somatostatin genetic variants modify the risk for Alzheimer¿s disease among finnish patients
Vepsäläinen S, Helisalmi S, Koivisto AM, Tapaninen T, Hiltunen M, Soininen H, Vepsäläinen S, Helisalmi S, Hiltunen M, Soininen H. 2007. Journal of neurology. 254: 1504-1508 A1 Journal article (refereed), original research -
Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers
Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H. 2007. Dementia and geriatric cognitive disorders. 24: 146-150 A1 Journal article (refereed), original research -
Subspace approaches for fMRI time series estimation
Niskanen EI, Tarvainen MP, Könönen M, Soininen H, Karjalainen PA, Könönen M. Teoksessa: (toim.) , 2007. Proceedings of the 29th Annual International Conference of the IEEE EMBS. s. 5485-5488. IOP Publishing A4 Conference proceedings -
The association study between DHCR24 polymorphisms and Alzheimer's disease
Lämsä R, Helisalmi S, Hiltunen M, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S. 2007. American journal of medical genetics. Part B : neuropsychiatric genetics. 144B: 906-910 A1 Journal article (refereed), original research -
Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study
Joyal CC, Putkonen A, Mancini-Marïe A, Hodgins S, Kononen M, Boulay L, Pihlajamaki M, Soininen H, Stip E, Tiihonen J, Aronen HJ, Könönen M. 2007. Schizophrenia research. 91: 97-102 A1 Journal article (refereed), original research -
Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment
Hämäläinen A, Tervo S, Grau-Olivares M, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala E-L, Nissinen A, Vanninen R, Soininen H, Hämäläinen A, Tervo S, Vanhanen M, Hallikainen M, Soininen H. 2007. Neuroimage. 37: 1122-1131 A1 Journal article (refereed), original research -
Work-related physical activity and the risk of dementia and Alzheimer's disease
Rovio S, Kåreholt I, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M, Soininen H. 2007. International journal of geriatric psychiatry. 22: 874-882 A1 Journal article (refereed), original research -
3-Year study of Donepezil therapy in Alzheimer¿s Disease: Effects of early and continuous therapy
Winblad B, Wimo A, Engedal K, Soininen H, Verhey F, Waldemar G, Wetterholm A-L, Haglund A, Zhang R, Schindler R, For the Donepezil Nordic Group, Soininen H. 2006. Dementia and geriatric cognitive disorders. 21: 353-363 A1 Journal article (refereed), original research -
Aromatase enzyme and Alzheimer¿s disease
Hiltunen M, Iivonen S, Soininen H, Hiltunen M, Soininen H. 2006. Minerva endocrinologica. 31: 61-73 A1 Journal article (refereed), original research -
Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
Zhou X-W, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei J-J. 2006. Neurobiology of disease. 22: 657-668 A1 Journal article (refereed), original research -
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population
Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453 A1 Journal article (refereed), original research -
Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary
Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Journal of neurology neurosurgery and psychiatry. 77: 421-422 A1 Journal article (refereed), original research -
Association of metabolic syndrome with Alzheimer disease: a population-based study
Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. 2006. Neurology. 67: 843-847 A1 Journal article (refereed), original research -
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
Buerger K, Ewers M, Pirttilä T, Zinkowski R, Alafuzoff I, Teipel SJ, DeBernardis J, Kerkman D, McCulloch C, Soininen H, Hampel H, Pirttilä T, Soininen H. 2006. Brain. 129: 3035-3041 A1 Journal article (refereed), original research -
Cerebrospinal fluid Abeta42, tau and phosphorylated tau predict progression in patients with cognitive impairment
Herukka S-K, Hallikainen M, Tervo S, Helisalmi S, Tapiola T, Soininen H, Pirttilä T, Hallikainen M, Tervo S, Helisalmi S, Soininen H, Pirttilä T. Teoksessa: Vellas B, Winblad B, Grundman M, Fitten LJ, Feldman H, Giacobini E, Kurz A(toim.) , 2006. Research and Practice in Alzheimer¿s Disease. s. 245-250. Serdi A3 Book section, Chapters in research books -
Determinants of costs of care for patients with Alzheimer¿s disease
Jönsson L, Jönhagen ME, Kilander L, Soininen H, Hallikainen M, Waldemar G, Nygaard H, Andreasen N, Winblad B, Wimo A, Soininen H, Hallikainen M. 2006. International journal of geriatric psychiatry. 21: 449-459 A1 Journal article (refereed), original research -
Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice
Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Neuroscience. 137: 1143-1152 A1 Journal article (refereed), original research -
Fat intake at midlife and risk of dementia and Alzheimer¿s disease: A population-based study
Laitinen MH, Ngandu T, Rovio S, Helkala E-L, Uusitalo U, Viitanen M, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. 2006. Dementia and geriatric cognitive disorders. 22: 99-107 A1 Journal article (refereed), original research -
Kliinis-neurofysiologiset tutkimukset
Soininen H, Partanen J. Teoksessa: Erkinjuntti T, Alhainen K, Rinne J, Soininen H(toim.) , 2006. Muistihäiriöt ja dementia. 2. uud. p.. s. 431-437. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Mikä on näyttö yli 80-vuotiaiden dementian hoidosta
Soininen H. 2006. Lääkärilehti. 61: 4215-4217 A2 Review article, Literature review, Systematic review -
Muistihäiriöiden ja dementian ennaltaehkäisy
Soininen H. Teoksessa: Erkinjuntti T, Alhainen K, Rinne J, Soininen H(toim.) , 2006. Muistihäiriöt ja dementia. 2. uud. p.. s. 464-471. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Muistihäiriöiden oirediagnostiikka
Soininen H, Hänninen T. Teoksessa: Erkinjuntti T, Alhainen K, Rinne J, Soininen H(toim.) , 2006. Muistihäiriöt ja dementia. 2. uud. p.. s. 82-92. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Muistihäiriöt ja dementia. 2. uud. p
Erkinjuntti T, Alhainen K, Rinne J, Soininen H. 2006. . . Duodecim D6 Edited professional book -
Patient- and proxy-reported utility in Alzheimer disease using the euroQoL
Jönsson L, Andreasen N, Kilander L, Soininen H, Waldemar G, Nygaard H, Winblad B, Jönhagen ME, Hallikainen M, Wimo A, Soininen H, Hallikainen M. 2006. Alzheimer disease and associated disorders. 20: 49-55 A1 Journal article (refereed), original research -
Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. 2006. The Lancet Neurology. 5: 735-741 A1 Journal article (refereed), original research -
The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: A voxel-based morphometric study
Pennanen C, Testa C, Boccardi M, Laakso MP, Hallikainen M, Helkala E-L, Hänninen T, Kivipelto M, Könönen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H, Könönen M, Hallikainen M, Tervo S, Soininen H, Laakso MP. 2006. Dementia and geriatric cognitive disorders. 22: 60-66 A1 Journal article (refereed), original research -
A voxel based morphometry study on mild cognitive impairment
Pennanen C, Testa C, Laakso MP, Hallikainen M, Helkala E-L, Hänninen T, Kivipelto M, Könönen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H, Laakso MP, Könönen M, Soininen H. 2005. Journal of neurology neurosurgery and psychiatry. 76: 11-14 A1 Journal article (refereed), original research -
CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
Herukka S-K, Hallikainen M, Soininen H, Pirttilä T, Hallikainen M, Soininen H, Pirttilä T. 2005. Neurology. 64: 1294-1297 A1 Journal article (refereed), original research -
Can mild cognitive impairment predict Alzheimer¿s disease?
Soininen H, Tuomainen S, Pennanen C, Hänninen T, Kivipelto M, Soininen H. Teoksessa: Hanin I, Cacabelos R, Fisher A(toim.) , 2005. Recent Progress in Alzheimer¿s and Parkinson¿s Disease. s. 191-195. Taylor & Francis A3 Book section, Chapters in research books -
Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects
Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Aronen HJ, Soininen H, Soininen H, könönen m. 2005. European journal of neuroscience. 22: 2095-2105 A1 Journal article (refereed), original research -
Estrogen receptor beta gene variants are associated with increased risk of Alzheimer¿s disease in women
Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2005. European journal of human genetics. 13: 1000-1006 A1 Journal article (refereed), original research -
Frontotemporal dementia as a neural system disease
Boccardi M, Sabbatoli F, Laakso MP, Testa C, Rossi R, Beltramello A, Soininen H, Frisoni GB, Laakso MP, Soininen H. 2005. Neurobiology of aging. 26: 37-44 A1 Journal article (refereed), original research -
Genetic analysis on BDNF and TrkB gene polymorphisms in Alzheimer's disease
Vepsäläinen S, Castren E, Helisalmi S, Iivonen S, Mannermaa A, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Vepsäläinen S, Helisalmi S, Iivonen S, Soininen H, Hiltunen M. 2005. Journal of neurology. 252: 423-428 A1 Journal article (refereed), original research -
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
Rovio S, Kåreholt I, Helkala E-L, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. 2005. The Lancet Neurology. 4: 705-711 A1 Journal article (refereed), original research -
Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alxheimer's disease brain
Li X, Alafuzoff I, Soininen H, Winblad B, Pei J-J, Soininen H. 2005. Febs journal. 272: 4211-4220 A1 Journal article (refereed), original research -
Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods
Chaudhuri JD, Hiltunen M, Nykänen M, Ylä-Herttuala S, Soininen H, Miettinen R, Hiltunen M, Soininen H. 2005. Neuroscience. 131: 557-566 A1 Journal article (refereed), original research -
Muistihäiriöiden varhaisdiagnostiikka kaipaa tehostamista
Soininen H, Soininen H. 2005. Lääkärilehti -
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer¿s disease
Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, Helkala E-L, Tuomilehto J, Soininen H, Nissinen A, Soininen H. 2005. Archives of neurology. 62: 1556-1560 A1 Journal article (refereed), original research -
Onko Alzheimer-lääkkeistä hyötyä?
Soininen H, Pirttilä T, Soininen H. 2005. Duodecim -
Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy
Miettinen R, Riedel A, Kalesnykas G, Kettunen H-P, Puoliväli J, Soininen H, Arendt T, Soininen H. 2005. Journal of chemical neuroanatomy. 30: 105-118 A1 Journal article (refereed), original research -
Response to letter by Bullock and Truyen
Jones R, Soininen H, Hager K, Aarsland D, Passmore P, Soininen H. 2005. International journal of geriatric psychiatry -
Structural correlates of early and late onset Alzheimer`s disease: voxel based morphometric study
Frisconi GB, Testa C, Sabattoli F, Beltramello A, Soininen H, Laakso MP, Laakso MP, Soininen H. 2005. Journal of neurology neurosurgery and psychiatry. 76: 112-114 A1 Journal article (refereed), original research -
Subgroups of Alzheimer¿s disease based on cerebrospinal fluid molecular markers
Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I, Soininen H, Pirttilä T. 2005. Annals of neurology. 58: 748-757 A1 Journal article (refereed), original research -
Visual assessment of medial temporal atrophy on MR films in Alzheimer¿s disease: comparison with volumetry
Bresciani L, Rossi R, Testa C, Geroldi C, Galluzzi S, Laakso MP, Beltramello A, Soininen H, Frisoni GB, Laakso MP, Soininen H. 2005. Aging clinical and experimental research. 17: 8-13 A1 Journal article (refereed), original research -
A comparison between the accurancy of voxel-based morphometry and hippocampal volumetry in Alzheimer`s disease
Testa C, Laakso MP, Sabattoli F, Rossi R, Beltramello A, Soininen H, Frisoni GB, Laakso MP, Soininen H. 2004. Journal of magnetic resonance imaging. 19: 274-282 A1 Journal article (refereed), original research -
A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer¿s disease
Jones RW, Soininen H, Hager K, Aarsland D, Passmore P, The DONGAL Study Group, Murthy A, Zhang R, Bahra R, Soininen H. 2004. International journal of geriatric psychiatry. 19: 58-67 A1 Journal article (refereed), original research -
APOE and modulation of Alzheimer¿s and frontotemporal dementia
Boccardi M, Sabattoli F, Testa C, Beltramello A, Soininen H, Frisoni GB, Soininen H. 2004. Neuroscience letters. 356: 167-170 A1 Journal article (refereed), original research -
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study
Anttila T, Helkala E-L, Viitanen M, Kåreholt I, Fratiglioni L, Winblad B, Soininen H, Tuomilehto J, Nissinen A, Kivipelto M, Soininen H. 2004. BMJ international edition. 329: 539-544 A1 Journal article (refereed), original research -
Alzheimerin taudin genetiikka
Hiltunen M, Helisalmi S, Kivipelto M, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2004. Duodecim. 120: 2425-2431 A2 Review article, Literature review, Systematic review -
Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons
Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2004. Neuroscience letters. 368: 181-185 A1 Journal article (refereed), original research -
Genetic variation in apolipoprotein D and Alzheimer¿s disease
Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder EH, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Koivisto AM, Soininen H. 2004. Journal of neurology. 251: 951-957 A1 Journal article (refereed), original research -
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala E-L, Vainio P, Vanninen R, Partanen K, Soininen H, Pennanen C, Kivipelto M, Tuomainen S, Hänninen T, Hallikainen M, Vanhanen M. 2004. Neurobiology of aging. 25: 303-310 A1 Journal article (refereed), original research -
Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects
Tervo S, Kivipelto M, Hänninen T, Vanhanen M, Hallikainen M, Mannermaa A, Soininen H, Tervo S, Kivipelto M, Hänninen T, Vanhanen M, Hallikainen M, Soininen H. 2004. Dementia and geriatric cognitive disorders. 17: 196-203 A1 Journal article (refereed), original research -
Mitochondrial DNA polymorphisms as risk factors for Parkinson¿s disease and Parkinson¿s disease dementia
Autere J, Moilanen JS, Finnilä S, Soininen H, Mannermaa A, Hartikainen P, Hallikainen M, Majamaa K, Soininen H. 2004. Human genetics. 115: 29-35 A1 Journal article (refereed), original research -
Muistihäiriöt ja dementia
Hänninen T, Soininen H, Soininen H. Teoksessa: Raitanen T, Hänninen T, Pajunen H, Suutama T(toim.) , 2004. Geropsykologia - vanhenemisen ja vanhuuden psykologia. s. 182-192. WSOY D2 Article in a professional book (incl. an introduction by the editor) -
Phosphorylated eukaryotic translation factor 4E is elevated in alzheimer brain
Li X, An W-L, Alafuzoff I, Soininen H, Winblad B, Pei J-J, Soininen H. 2004. Neuroreport. 15: 2237-2240 A1 Journal article (refereed), original research -
Polymorphisms in neprilysin gene affect the risk of Alzheimer¿s disease in Finnish patients
Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto AM, Alafuzoff I, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Koivisto AM, Soininen H, Iivonen S. 2004. Journal of neurology neurosurgery and psychiatry. 75: 1746-1748 A1 Journal article (refereed), original research -
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease
Iivonen S, Corder E, Lehtovirta M, Helisalmi S, Mannermaa A, Vepsäläinen S, Hänninen T, Soininen H, Hiltunen M, Iivonen S, Hiltunen M, Soininen H, Helisalmi S, Vepsäläinen S. 2004. Neurology. 62: 1170-1176 A1 Journal article (refereed), original research -
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population
Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto AM, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C, Soininen H. 2004. Neurology. 63: 173-175 A1 Journal article (refereed), original research -
Serum testosterone levels in males with Alzheimer¿s disease
Pennanen C, Laakso MP, Kivipelto M, Ramberg J, Soininen H, Laakso MP, Soininen H. 2004. Journal of neuroendocrinology. 16: 95-98 A1 Journal article (refereed), original research -
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans
Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Hämäläinen A, Soininen H, Aronen HJ, Könönen M, Soininen H. 2004. European journal of neuroscience. 19: 1939-1949 A1 Journal article (refereed), original research -
Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer¿s disease in Finnish patients
Mattila KM, Hiltunen M, Rinne JO, Mannermaa A, Röyttä M, Alafuzoff I, Laippala P, Soininen H, Lehtimäki T. 2003. Neuroscience letters. 337: 61-63 A1 Journal article (refereed), original research -
An economic evaluation of donepezil in mild to moderate Alzheimer¿s disease: Results of a 1-year, double-blind, randomized trial
Wimo A, Winblad B, Engedal K, Soininen H, Verhey F, Waldemar G, Wetterholm A-L, Mastey V, Haglund A, Zhang R, Miceli R, Chin W, Subbiah P, Donepezil Nordi Study Group, Hallikainen M, Jäkälä P, Riekkinen M. 2003. Dementia and geriatric cognitive disorders. 15: 44-54 A1 Journal article (refereed), original research -
Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers
Laakso MP, Hiltunen Y, Könönen M, Kivipelto M, Koivisto A, Hallikainen M, Soininen H, Laakso MP. 2003. Journal of neural transmission. 110: 267-275 A1 Journal article (refereed), original research -
Encoding of novel picture pairs activates the perirhinal cortex: An fMRI study
Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Mikkonen M, Jalkanen V, Partanen K, Aronen HJ, Soininen H. 2003. Hippocampus. 13: 67-80 A1 Journal article (refereed), original research -
Heparan sulfate proteoglycan 2 polymorphism in Alzheimer¿s disease and correlation with neuropathology
Iivonen S, Helisalmi S, Mannermaa A, Alafuzoff I, Lehtovirta M, Soininen H, Hiltunen M. 2003. Neuroscience letters. 352: 146-150 A1 Journal article (refereed), original research -
Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC
Frisoni GB, Scheltens P, Galluzzi S, Nobili FM, Fox NC, Robert PH, Soininen H, Wahlund L-O, Waldemar G, Salmon E. 2003. Journal of neurology neurosurgery and psychiatry. 74: 1371-1381 A2 Review article, Literature review, Systematic review -
Reelin-immunoreactive cajal-retzius cells: the entorhinal cortex in normal aging and alzheimer¿s disease
Riedel A, Miettinen R, Stieler J, Mikkonen M, Alafuzoff I, Soininen H, Arendt T. 2003. Acta neuropathologica. 106: 291-302 A1 Journal article (refereed), original research -
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease
Parkkinen L, Soininen H, Alafuzoff I. 2003. Journal of neuropathology and experimental neurology. 62: 363-367 A1 Journal article (refereed), original research -
The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia
Boccardi M, Laakso MP, Bresciani L, Galluzzi S, Geroldi C, Beltramello A, Soininen H, Frisoni GB, Laakso MP. 2003. Neurobiology of aging. 24: 95-103 A1 Journal article (refereed), original research -
The density of endothelial cells in brain tissue is influenced by gender, age and concomitant brain pathology
Berdel B, Koivisto A, Soininen H, Laakso M, Alafuzoff I. 2003. BRAIN AGING. 3: 29-32 A1 Journal article (refereed), original research -
Amygdaloid atrophy in frontotemporal dementia and Alzheimer¿s disease
Boccardi M, Pennanen C, Laakso MP, Testa C, Geroldi C, Soininen H, Frisoni GB. 2002. Neuroscience letters. 335: 139-143 A1 Journal article (refereed), original research -
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H. 2002. Annals of internal medicine. 137: 149-155 A1 Journal article (refereed), original research -
Auditory adaptation is differentially impaired in familial and sporadic Alzheimer`s disease
Tarkka IM, Lehtovirta M, Soininen H, Pääkkönen A, Karhu J, Partanen J. 2002. Biomedicine and pharmacotherapy. 56: 45-49 A1 Journal article (refereed), original research -
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation
Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T. 2002. Biochemical and biophysical research communications. 298: 693-698 A1 Journal article (refereed), original research -
Detection of grey matter loss in mild Alzheimer¿s disease with voxel based morphometry
Frisoni GB, Testa C, Zorzan A, Sabattoli F, Beltramello A, Soininen H, Laakso MP. 2002. Journal of neurology neurosurgery and psychiatry. 73: 657-664 A1 Journal article (refereed), original research -
EEG as a diagnostic tool in dementia
Soininen H, Partanen J. Teoksessa: Qizilbash N, Schneider LS, Chui H, Tariot P, Brodaty H, Kaye J, Erkinjuntti T(toim.) , 2002. Evidence-based Dementia Practice. s. 170-175. Blackwell A3 Book section, Chapters in research books -
Hypertension and hypercholesterolaemia as risk factors for Alzheimer¿s disease: potential for pharmacological intervention
Kivipelto M, Laakso MP, Tuomilehto J, Nissinen A, Soininen H. 2002. Cns drugs. 16: 435-444 A1 Journal article (refereed), original research -
Hypertension and white matter lesions of the brain
Kivipelto M, Soininen H, Tuomilehto J. 2002. Journal of hypertension. 20: 387-389 A1 Journal article (refereed), original research -
Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T. 2002. MOLECULAR BRAIN RESEARCH. 106: 50-56 A1 Journal article (refereed), original research -
Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease
Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Dementia and geriatric cognitive disorders. 14: 123-127 A1 Journal article (refereed), original research -
Midlife income, occupation, APOE status, and dementia
Anttila T, Helkala E-L, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Mannermaa A, Tuomilehto J, Soininen H, Nissinen A. 2002. Neurology. 59: 887-893 A1 Journal article (refereed), original research -
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland
Autere JM, Hiltunen MJ, Mannermaa A, Jäkälä PA, Hartikainen PH, Majamaa K, Alafuzoff I, Soininen HS. 2002. European journal of neurology. 9: 479-483 A1 Journal article (refereed), original research -
Muistihäiriö: normaalia ikääntymistä vai dementiaa
Soininen H, Hänninen T. 2002. Lääkärilehti. 57: 2183-2185 A2 Review article, Literature review, Systematic review -
Neuropathology and ethiopathogenesis of Alzheimer¿s disease
Alafuzoff I, Soininen H. Teoksessa: Qizilbash N, Sneider LS, Chui H, Tariot P, Brodaty H, Kaye J, Erkinjuntti T(toim.) , 2002. Evidence-based Dementia Practice. s. 244-259. Blackwell A3 Book section, Chapters in research books -
Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism
Laakso MP, Gunning-Dixon F, Vaurio O, Repo-Tiihonen E, Soininen H, Tiihonen J. 2002. Psychiatry research: neuroimaging. 114: 95-102 D1 Article in a trade journal -
Prevalence of mild cognitive impairment: a population-based study in elderly subjects
Hänninen T, Hallikainen M, Tuomainen S, Vanhanen M, Soininen H. 2002. Acta neurologica scandinavica. 106: 148-154 A1 Journal article (refereed), original research -
Radial width of the temporal horn: a sensitive measure in Alzheimer disease
Frisoni GB, Geroldi C, Beltramello A, Bianchetti A, Binetti G, Bordiga G, DeCarli C, Laakso MP, Soininen H, Testa C, Zanetti O, Trabucchi M. 2002. American journal of neuroradiology. 23: 35-47 D1 Article in a trade journal -
Relevance of APOE genotype in diagnostics and therapy of Alzheimer¿s disease
Soininen H. 2002. REVIEW SERIES. DEMENTIA. : 15-18 A1 Journal article (refereed), original research -
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer¿s disease
Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, Soininen H. 2002. Neuroscience. 113: 301-310 A1 Journal article (refereed), original research -
Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure - a population-based study
Helkala E-L, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Tuomilehto J, Soininen H, Nissinen A. 2002. Acta neurologica scandinavica. 106: 341-346 A1 Journal article (refereed), original research -
Vascular risk factors, ApoE epsilon4 allele, and gender and the risk of Alzheimer¿s disease: perspectives on prevention
Kivipelto M, Helkala E-L, Nissinen A, Soininen H, Tuomilehto J. 2002. Drug development research. 56: 85-94 A1 Journal article (refereed), original research -
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
Winblad B, Engedal K, Soininen H, Verhey F, Waldemar G, Wimo A, Wetterholm A-L, Zhang R, Haglund A, Subbiah P, the Donepezil Nordic Study Group, Hallikainen M, Jäkälä P, Riekkinen M. 2001. Neurology. 57: 489-495 A1 Journal article (refereed), original research -
APOE-epsilon4 is associated with weight loss in women with AD. A population-based study
Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M. 2001. Neurology. 56: 655-659 A1 Journal article (refereed), original research -
An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin
Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. Neurogenetics -
Benefits of donepezil on cognition, function and neuropsychiatric symptoms in patients with mild and moderate Alzheimr¿s disease over one year
Waldemar G, Winblad B, Engedal K, Soininen H, Verhey F, Wimo A, Wetterholm A-L, Zhang R, Haglund A, Subbiah P, The Donepezil Nordic Study Group. Teoksessa: Igbal K, Sisodia SS, Winblad B(toim.) , 2001. Alzheimer¿s Disease: Advances in Ethiology, Pathogenesis and Therapeutics. s. 725-738. John Wiley & Sons A3 Book section, Chapters in research books -
Beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality
Kerokoski P, Soininen H, Pirttilä T. 2001. Neurochemistry international. 38: 127-134 A1 Journal article (refereed), original research -
CSF tau and Abeta42 levels in patients with Down¿s syndrome
Tapiola T, Soininen H, Pirttilä T. 2001. Neurology. 56: 979 A1 Journal article (refereed), original research -
Genes, proteins and brain disease
Hiltunen M, Soininen H. 2001. Trends in molecular medicine. 7: 382-383 A2 Review article, Literature review, Systematic review -
Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland
Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Neurology. 57: 1663-1668 A1 Journal article (refereed), original research -
Hippocampal plasticity in Alzheimer¿s disease
Mikkonen M, Soininen H, Alafuzoff I, Miettinen R. 2001. Reviews in the neurosciences. 12: 311-325 A1 Journal article (refereed), original research -
Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNA
Finnilä S, Autere J, Lehtovirta M, Hartikainen P, Mannermaa A, Soininen H, Majamaa K. 2001. Journal of medical genetics -
Kliinis-neurofysiologiset tutkimukset
Soininen H, Partanen J. Teoksessa: Erkinjuntti T, Rinne J, Alhainen K, Soininen H(toim.) , 2001. Muistihäiriöt ja dementia. s. 403-409. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Midlife vascular risk factors and Alzheimer¿s disease in later life: longitudinal, population based study
Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissien A. 2001. BMJ international edition. 322: 1447-1451 A1 Journal article (refereed), original research -
Midlife vascular risk factors and late-life mild cognitive impairment. A population-based study
Kivipelto M, Helkala E-L, Hänninen T, Laakso MP, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A. 2001. Neurology. 56: 1683-1689 A1 Journal article (refereed), original research -
Muistihäiriöiden ja dementian ennaltaehkäisy
Soininen H. Teoksessa: Erkinjuntti T, Rinne J, Alhainen K, Soininen H(toim.) , 2001. Muistihäiriöt ja dementia. s. 435-441. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Muistihäiriöiden oirediagnostiikka
Soininen H, Hänninen T. Teoksessa: Erkinjuntti T, Rinne J, Alhainen K, Soininen H(toim.) , 2001. Muistihäiriöt ja dementia. s. 77-87. Helsinki D2 Article in a professional book (incl. an introduction by the editor) -
Muistihäiriöt ja dementia
Erkinjuntti T, Rinne J, Soininen H. Teoksessa: Soinila S, Kaste M, Launes J, Somer H(toim.) , 2001. Duodecim. s. 322-341. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Muistihäiriöt ja dementia
Erkinjuntti T, Rinne J, Alhainen K, Soininen H. 2001. . . Duodecim D6 Edited professional book -
Psychopathy and the posterior hippocampus
Laakso MP, Vaurio O, Koivisto E, Savolainen L, Eronen M, Aronen HJ, Hakola P, Repo E, Soininen H, Tiihonen J. 2001. Behavioural brain research. 118: 187-193 A1 Journal article (refereed), original research -
Tacrine may alter APP-like protein levels in the lumbar CSF of Alzheimer patients
Clarke NA, Soininen H, Gustafson L, Minthon L, Alhainen K, Francis PT. 2001. International journal of geriatric psychiatry. 16: 1104-1106 A1 Journal article (refereed), original research -
The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis
Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T. 2001. Biochemical and biophysical research communications. 280: 998-1002 A1 Journal article (refereed), original research -
The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer¿s disease
Kraszpulski M, Soininen H, Helisalmi S, Alafuzoff I. 2001. Acta neurologica scandinavica. 103: 88-92 A1 Journal article (refereed), original research -
alpha-Synuclein pathology is highly dependent on the case selection
Parkkinen L, Soininen H, Laakso M, Alafuzoff I. 2001. Neuropathology and applied neurobiology. 27: 314-325 A1 Journal article (refereed), original research -
A longitudinal quantitative EEG study of Alzheimer¿s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Hiltunen J, Helisalmi S, Hartikainen P, Riekkinen P Sr, Soininen H. 2000. Dementia and geriatric cognitive disorders. 11: 29-35 A1 Journal article (refereed), original research -
A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism
Laakso MP, Vaurio O, Savolainen L, Repo E, Soininen H, Aronen HJ, Tiihonen J. 2000. Behavioural brain research. 109: 177-186 A1 Journal article (refereed), original research -
APOE4 relevance to early diagnosis and treatment of Alzhemer¿s disease
Soininen H. Teoksessa: Battistin L, Korczyn AD(toim.) , 2000. 5th Congress of the European Society for Clinical Neuropharmacology. s. 124-130. Monduzzi A4 Conference proceedings -
Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer¿s disease: a volumetric MRI study
Geroldi C, Laakso MP, DeCarli C, Beltramello A, Biancetti A, Soininen H, Trabucchi M, Frisoni GB. 2000. Journal of neurology neurosurgery and psychiatry. 68: 93-96 A1 Journal article (refereed), original research -
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study
Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. 2000. Neuroepidemiology. 19: 327-332 A1 Journal article (refereed), original research -
DNA fragmentation, gliosis and histological hallmarks of Alzheimer¿s disease
Overmyer M, Kraszpulski M, Helisalmi S, Soininen H, Alafuzoff I. 2000. Acta neuropathologica. 100: 681-687 A1 Journal article (refereed), original research -
Diagnosis of Alzheimer`s disease: MRI of the hippocampus vs delayed recall
Laakso MP, Hallikainen M, Hänninen T, Partanen K, Soininen H. 2000. Neuropsychologia. 38: 579-584 A1 Journal article (refereed), original research -
Early diagnosis of Alzheimer¿s disease
Soininen H. 2000. PATHWAYS: THE NOVARTIS JOURNAL -
Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer¿s disease: a morphometric MRI study
Laakso MP, Frisoni GB, Könönen M, Mikkonen M, Beltramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ. 2000. Biological psychiatry. 47: 1056-1063 A1 Journal article (refereed), original research -
Hippocampus in Alzheimer¿s disease: A 3-year follow-up MRI study
Laakso MP, Lehtovirta M, Partanen K, Riekkinen PJ Sr, Soininen H. 2000. Biological psychiatry. 47: 557-561 A1 Journal article (refereed), original research -
How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer¿s disease ? A review of neuroimaging studies
Lehtovirta M, Laakso MP, Frisoni GB, Soininen H. 2000. Neurobiology of aging. 21: 293-300 A1 Journal article (refereed), original research -
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination?
Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. European journal of human genetics. 8: 259-266 A1 Journal article (refereed), original research -
Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts
Fratiglioni L, Launer LJ, Andersen K, Breteler MMB, Copeland JRM, Dartigues J-F, Lobo A, Martinez-Lage J, Soininen H, Hofman A, for the Neurologic Diseases in the Elderly Research Group. 2000. NEUROLOGY. SUPPLEMENT. 54: S10-S15 A1 Journal article (refereed), original research -
Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer¿s disease?
Helisalmi S, Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Alafuzoff I, Ryynänen M, Soininen H. 2000. Neuroscience letters. 278: 65-68 A1 Journal article (refereed), original research -
La rilevazione delle alterazioni strutturali cerebrali nella malttia di Alzheimer: tecniche e strumenti
Scheltens P, Wahlund L-O, Soininen H, Laakso M, Partanen K, Resconi G, Rossini PM, Tecchio F, Fox N. Teoksessa: Frisoni GB, Trabucchi M(toim.) , 2000. Il neuroimaging nella diagnosi di malattia di Alzheimer, Problemi, strumenti, linee-guida. s. 21-34. Il Pensiero Scientifico Editore A3 Book section, Chapters in research books -
Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs
Alafuzoff I, Overmyer M, Helisalmi S, Soininen H. 2000. Journal of Alzheimer's disease. 2: 37-46 A1 Journal article (refereed), original research -
MR imaging of the hippocampus in normal pressure hydrocephalus: correlations with cortical Alzheimer`s disease confirmed by pathologic analysis
Savolainen S, Laakso MP, Paljärvi L, Alafuzoff I, Hurskainen H, Partanen K, Soininen H, Vapalahti M. 2000. American journal of neuroradiology. 21: 409-414 A1 Journal article (refereed), original research -
Mild cognitive impairment as a warning sign of dementia
Hänninen T, Soininen H. Teoksessa: Vellas B, Fitten LJ(toim.) , 2000. Research and Practice in Alzheimer¿s Disease. s. 93-97. Springer A3 Book section, Chapters in research books -
Milloin aivot tulee kuvata
Soininen H, Sulkava R. 2000. Duodecim -
Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow
Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R. 2000. Neuroscience. 96: 515-522 A1 Journal article (refereed), original research -
Muistihäiriö- ja dementiapotilaan toimintakyvyn ja sairauden vaikeusasteen arviointi
Suomen muistitutkimusyksiköiden asiantuntijatyöryhmä, Rosenvall A, Viramo P, Juva K, Alhainen K, Koivisto K, Pirttilä T, Rinne J, Saarela T, Soininen H, Vanhanen M, Erkinjuntti T. 2000. Lääkärilehti. 55: 2299-2304 A2 Review article, Literature review, Systematic review -
Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts
Lobo A, Launer LJ, Fratiglioni L, Andersen K, Carlo AD, Breteler MMB, Copeland JRM, Dartigues J-F, Jagger C, Martinez-Lage J, Soininen H, Hofman A, for the Neurologic Diseases in the Elderly Research Group. 2000. NEUROLOGY. SUPPLEMENT. 54: S4-S9 A1 Journal article (refereed), original research -
Prognosis with dementia in Europe: a collaborative study of population-based cohorts
Jagger C, Andersen K, Breteler MMB, Copeland JRM, Helmer C, Baldereschi M, Fratiglioni L, Lobo A, Soininen H, Hofman A, Launer LJ, for the Neurolgic Diseases in the Elderly Research Group. 2000. NEUROLOGY. SUPPLEMENT. 54: S16-S20 A1 Journal article (refereed), original research -
Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer¿s disease
Tapiola T, Pirttilä T, Mehta PD, Alafuzoff I, Lehtovirta M, Soininen H. 2000. Neurobiology of aging. 21: 735-740 A1 Journal article (refereed), original research -
Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer¿s disease
Alafuzoff I, Helisalmi S, Heinonen EH, Reinikainen K, Hallikainen M, Soininen H, Koivisto K. 2000. European journal of clinical pharmacology. 55: 815-819 A1 Journal article (refereed), original research -
Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia
Alafuzoff I, Helisalmi S, Mannermaa A, Soininen H. 2000. Annals of the New York Academy of Sciences. 903: 244-251 A1 Journal article (refereed), original research -
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with Alzheimer¿s disease or the link apolipoprotein E
Helisalmi S, Valve R, Karvonen MK, Hiltunen M, Pirskanen M, Mannermaa A, Koulu M, Pesonen U, Uusitupa M, Soininen H. 2000. Neuroscience letters. 287: 25-28 A1 Journal article (refereed), original research -
Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and concentration in Alzheimer¿s disease
Tapiola T, Pirttilä T, Mikkonen M, Mehta PD, Alafuzoff I, Koivisto K, Soininen H. 2000. Neuroscience letters. 280: 119-122 A1 Journal article (refereed), original research -
Varhaisen dementian kuvantamisdiagnostiikka
Partanen K, Laakso M, Erkinjuntti T, Soininen H. 2000. Duodecim. 116: 1049-1058 A2 Review article, Literature review, Systematic review -
Vascular dementia and white matter changes: electrophyciological tests
Partanen J, Soininen H, Riekkinen P. Teoksessa: Pantoni L, Inzitari D, Wallin A(toim.) , 2000. The Matter of White Matter. s. 171-178. Academic Pharmaceutical Productions D2 Article in a professional book (incl. an introduction by the editor) -
Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study
Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Laakso M, Partanen K, Soininen H, Aronen HJ. 2000. Annals of neurology. 47: 470-476 A1 Journal article (refereed), original research -
APOE type and MRI volumetric changes as predictor of Alzheimer¿s disease
Soininen HS, Riekkinen P Sr. Teoksessa: Vellas B, Fitten LJ(toim.) , 1999. Research and Practice in Alzheimer¿s Disease. s. 95-98. Springer A3 Book section, Chapters in research books -
APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD
Geroldi C, Pihlajamäki M, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, Trabucchi M, Frisoni GB. 1999. Neurology. 53: 1825-1832 A1 Journal article (refereed), original research -
Astrogliosis and the ApoE genotype: an immunohistochemical study of postmortem human brain tissue
Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Dementia and geriatric cognitive disorders. 10: 252-257 A1 Journal article (refereed), original research -
Beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients
Alafuzoff I, Helisalmi S, Mannermaa A, Riekkinen P Sr, Soininen H. 1999. Stroke. 30: 613-618 A1 Journal article (refereed), original research -
Beta-amyloid load, astroglia and microglia in Alzheimer¿s disease: association with apoE genotype
Alafuzoff I, Overmyer M, Helisalmi S, Riekkinen P Sr, Soininen H. 1999. ALZHEIMER'S RESEARCH. 2: 283-289 A1 Journal article (refereed), original research -
Cerebrospinal fluid aspartate aminotransferase activity is increased in Alzheimer¿s disease
Tapiola T, Lehtovirta M, Pirttilä T, Alafuzoff I, Riekkinen P Sr, Soininen H. Teoksessa: Iqbal K, Swaab DF, Winblad B, Wisniewski HM(toim.) , 1999. Alzheimer¿s Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics. s. 193-197. John Wiley & Sons A3 Book section, Chapters in research books -
Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease
Juottonen K, Laakso MP, Partanen K, Soininen H. 1999. American journal of neuroradiology. 20: 139-144 A1 Journal article (refereed), original research -
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer¿s disease
Frisoni GB, Laakso MP, Beltramello A, Geroldi C, Bianchetti A, Soininen H, Trabucchi M. 1999. Neurology. 52: 91-100 A1 Journal article (refereed), original research -
Hippocampal plasticity in Alzheimer¿s disease: changes in highly polysialylated NCAM immunoreactivity in the hippocampal formation
Mikkonen M, Soininen H, Tapiola T, Alafuzoff I, Miettinen R. 1999. European journal of neuroscience. 11: 1754-1764 A1 Journal article (refereed), original research -
Kognitiiviset testit muistihäiriöiden ja alkavan dementian varhaisdiagnostiikassa: CERAD-tehtäväsarja
Hänninen T, Pulliainen V, Salo J, Hokkanen L, Erkinjuntti T, Koivisto K, Viramo P, Soininen H, Suomen muistitutkimusyksiköiden asiantuntijaryhmä. 1999. Lääkärilehti. 54: 1967-1975 A2 Review article, Literature review, Systematic review -
Kuka on vaarassa sairastua Alzheimerin tautiin ?
Soininen H, Hänninen T. 1999. Lääkärilehti. 54: 1519-1523 A2 Review article, Literature review, Systematic review -
Lievä kognitiivinen heikentyminen dementian varhaisena merkkinä
Hänninen T, Soininen H. 1999. Duodecim. 115: 381-388 A2 Review article, Literature review, Systematic review -
Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer`s disease patients
Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Helisalmi S, Ryynänen M, Riekkinen P Sr, Soininen H. 1999. European journal of human genetics. 7: 652-658 A1 Journal article (refereed), original research -
Prognosis with dementia: results from a European collaborative analysis of population-based studies
Jagger C, Andersen K, Breteler MMB, Copeland RJM, Dartigues J-F, Di Carlo A, Fratiglioni L, Lobo A, Schmidt R, Soininen H, Hofman A, Launer LJ. Teoksessa: Iqbal K, Swaab DF, Winblad B, Wisniewski HM(toim.) , 1999. Alzheimer¿s Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics. s. 39-44. John Wiley & Sons A3 Book section, Chapters in research books -
Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer¿s disease patients and control individuals
Helisalmi S, Hiltunen M, Valonen P, Mannermaa A, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 1999. Journal of neurology. 246: 821-824 A1 Journal article (refereed), original research -
Rapidly progressive multifocal leukoencephalopathy with substantial cell-mediated inflammatory response and with cognitive decline of non-Alzheimer type in a 75-year-old female patient
Alafuzoff I, Hartikainen P, Hanninen T, Partanen K, Kuikka J, Syrjänen K, Naukkarinen A, Soininen H. 1999. Clinical neuropathology. 18: 113-123 A1 Journal article (refereed), original research -
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue
Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P Sr, Alafuzoff I. 1999. Acta neuropathologica. 97: 383-392 A1 Journal article (refereed), original research -
Regional differences in the incidence of dementia in Europe: EURODEM collaborative analyses
Launer LJ, Fratiglioni L, Andersen K, Breteler MMB, Copeland RJM, Dartigues J-F, Lobo A, Martinez-Lage J, Soininen H, Hofman A. Teoksessa: Iqbal K, Swaab DF, Winblad B, Wisniewski HM(toim.) , 1999. Alzheimer¿s Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics. s. 9-15. John Wiley & Sons A3 Book section, Chapters in research books -
Subfield- and layer-specific changes in parvalbumin, calretinin and calbindin-D28k immunoreactivity in the entorhinal cortex in Alzheimer`s disease
Mikkonen M, Alafuzoff I, Tapiola T, Soininen H, Miettinen R. 1999. Neuroscience. 92: 515-532 A1 Journal article (refereed), original research -
Type-2 diabetes and cognitive function in a non-demented population
Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1999. Acta neurologica scandinavica. 100: 97-101 A1 Journal article (refereed), original research -
ApoE and memory in Alzheimer¿s disease
Soininen HS, Riekkinen PJ Sr. Teoksessa: Fisher A, Hanin I, Yoshida M(toim.) , 1998. Progress in Alzheimer¿s and Parkinson¿s Diseases. s. 13-16. Plenum A3 Book section, Chapters in research books -
Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer¿s disease patients
Hiltunen M, Mannermaa A, Helisalmi S, Koivisto A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Neuroscience letters. 250: 69-71 A1 Journal article (refereed), original research -
CSF tau is related to apolipoprotein E genotype in early Alzheimer's disease
Tapiola T, Lehtovirta M, Ramberg J, Helisalmi S, Linnaranta K, Riekkinen P Sr, Soininen H. 1998. Neurology. 50: 169-174 A1 Journal article (refereed), original research -
Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala
Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1998. Brain research. 783: 355-358 A1 Journal article (refereed), original research -
Cognitive function in an elderly population with persistent impaired glucose tolerance
Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1998. Diabetes care. 21: 398-402 A1 Journal article (refereed), original research -
Consensus report of the working group on: Molecular and biochemical markers of Alzheimer¿s disease
The Ronald and Nancy Reagan Research Institute of the Alzheimer's ..., Riekkinen PJ, Soininen HS. 1998. Neurobiology of aging. 19: 109-116 A1 Journal article (refereed), original research -
Early diagnostic indices for the prevention of Alzheimer¿s disease
Soininen HS, Scheltens P. 1998. Annals of medicine. 30: 553-559 A1 Journal article (refereed), original research -
Glucose intolerance, cognitive impairment and Alzheimer¿s disease
Vanhanen M, Soininen H. 1998. Current opinion in neurology. 11: 673-677 A1 Journal article (refereed), original research -
Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson`s disease patients
Riekkinen P Jr, Kejonen K, Laakso MP, Soininen H, Partanen K, Riekkinen M. 1998. Neuroreport. 9: 1507-1511 A1 Journal article (refereed), original research -
Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer¿s disease
Tapiola T, Lehtovirta M, Pirttilä T, Alafuzoff I, Riekkinen P, Soininen H. 1998. The Lancet -
Longitudinal SPECT study in Alzheimer`s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 64: 742-746 A1 Journal article (refereed), original research -
Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer`s disease
Pirttilä T, Koivisto K, Mehta PD, Reinikainen K, Kim KS, Kilkku O, Heinonen E, Soininen H, Riekkinen P Sr, Wisniewski HM. 1998. Neuroscience letters. 249: 21-24 A1 Journal article (refereed), original research -
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices
Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A. 1998. American journal of neuroradiology. 19: 659-671 A1 Journal article (refereed), original research -
MRI of the hippocampus in Alzheimer`s disease: sensitivity, specificity, and analysis of the incorrectly classified subjects
Laakso MP, Soininen H, Partanen K, Lehtovirta M, Hallikainen M, Hänninen T, Helkala E-L, Vainio P, Riekkinen PJ Sr. 1998. Neurobiology of aging. 19: 23-31 A1 Journal article (refereed), original research -
Major decrease in the volume of the entorhinal cortex in patients with Alzheimer`s disease carrying the apolipoprotein E epsilon4 allele
Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen PJ Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 65: 322-327 A1 Journal article (refereed), original research -
Pitfalls in the quantitative estimation of beetta-amyloid immunoreactivity in human brain tissue
Kraszpulski M, Soininen H, Riekkinen P Sr, Alafuzoff I. 1998. Histochemistry and cell biology. 110: 439-445 A1 Journal article (refereed), original research -
Reduction of noradrenaline impairs attention and dopamine depletion slows responses in Parkinson`s disease
Riekkinen M, Kejonen K, Jäkälä P, Soininen H, Riekkinen P Jr. 1998. European journal of neuroscience. 10: 1429-1435 A1 Journal article (refereed), original research -
Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex
Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A. 1998. Annals of neurology. 44: 923-934 A1 Journal article (refereed), original research -
Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease
Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H. 1998. Neurobiology of aging. 19: 15-22 A1 Journal article (refereed), original research -
Age-associated memory impairment Normal aging or warning of dementia?
Hänninen T, Soininen H. 1997. Drugs and aging. 11: 480-489 A1 Journal article (refereed), original research -
Alzheimerin taudin hoito
Soininen H. 1997. Duodecim. 113: 1739-1746 A2 Review article, Literature review, Systematic review -
Alzheimerin taudin perinnöllisyys
Lehtovirta M, Soininen H. 1997. Lääkärilehti. 52: 177-180 D1 Article in a trade journal -
Apolipoprotein E and temporal lobe pathology: magnetic resonance imaging and population-based studies
Riekkinen PJ Sr, Soininen HS. Teoksessa: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM(toim.) , 1997. Alzheimer`s Disease: Biology, Diagnosis and Therapeutics. s. 145-148. John Wiley & Sons A3 Book section, Chapters in research books -
Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains
Pirttilä T, Soininen H, Mehta PD, Heinonen O, Lehtimäki T, Bogdanovic N, Paljärvi L, Kim KS, Kosunen O, Winblad B, Riekkinen P Sr, Wisniewski HM. 1997. Neurobiology of aging. 18: 121-127 A1 Journal article (refereed), original research -
Challenge of Alzheimer`s disease is taken in Finland
Soininen H. 1997. UNFORGETTABLE. : 39-40 E1 Popularised article, newspaper article -
Decline of frontal lobe functions in subjects with age-associated memory impairment
Hänninen T, Hallikainen M, Koivisto K, Partanen K, Laakso MP, Riekkinen PJ Sr, Soininen H. 1997. Neurology. 48: 148-153 A1 Journal article (refereed), original research -
Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex
Mikkonen M, Soininen H, Pitkänen A. 1997. Journal of comparative neurology. 388: 64-88 A1 Journal article (refereed), original research -
Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence
Salminen A, Helenius M, Lahtinen T, Korhonen P, Tapiola T, Soininen H, Solovyan V. 1997. Biochemical and biophysical research communications. 238: 712-716 A1 Journal article (refereed), original research -
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Van Duijn CM, for the APOE and Alzheimer Disease Meta Analysis Consorium, Koivisto K, Lehtovirta M, Riekkinen P Sr, Kuusisto J, Laakso M, Soininen H. 1997. JAMA : Journal of the American Medical Association. 278: 1349-1356 A1 Journal article (refereed), original research -
Fragile-X: Neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes
Jäkälä P, Hänninen T, Ryynänen M, Laakso M, Partanen K, Mannermaa A, Soininen H. 1997. Journal of clinical investigation. 100: 331-338 A1 Journal article (refereed), original research -
Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease
Riekkinen P Jr, Riekkinen M, Soininen H, Kuikka J, Laakso M, Riekkinen P Sr. 1997. Neuroreport. 8: 1845-1849 A1 Journal article (refereed), original research -
Glutamate-induced changes in the DNA-binding complexes of transcription factor YY1 in cultured hippocampal and cerebellar granule cells
Korhonen P, Huotari V, Soininen H, Salminen A. 1997. MOLECULAR BRAIN RESEARCH. 52: 330-333 A1 Journal article (refereed), original research -
Lack of association between presenilin-1 polymorphism, Alzheimer's disease and apolipoprotein E
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. ALZHEIMER'S RESEARCH. 3: 159-161 A1 Journal article (refereed), original research -
MRI volumetry of the hippocampus: the effect of slice thickness on volume formation
Laakso MP, Juottonen K, Partanen K, Vainio P, Soininen H. 1997. Magnetic resonance imaging. 15: 263-265 A1 Journal article (refereed), original research -
No association between alfa1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer`s disease
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. Neuroscience letters. 231: 56-58 A1 Journal article (refereed), original research -
Relationship between EEG reactivity and neuropsychological tests in vascular dementia
Partanen J, Soininen H, Helkala E-L, Könönen M, Kilpeläinen R, Riekkinen P. 1997. Journal of neural transmission. 104: 905-912 A1 Journal article (refereed), original research -
Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function
Vanhanen M, Koivisto K, Karjalainen L, Helkala E-L, Laakso M, Soininen H, Riekkinen P Sr. 1997. Neuroreport. 8: 1527-1530 A1 Journal article (refereed), original research -
THA disrupts mismatch negativity in Alzheimer disease
Riekkinen P Jr, Pääkkönen A, Karhu J, Partanen J, Soininen H, Laakso M, Riekkinen P Sr. 1997. Psychopharmacology. 133: 203-206 A1 Journal article (refereed), original research -
The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients
Riekkinen P Jr, Soininen H, Partanen J, Pääkkönen A, Helisalmi S, Riekkinen P Sr. 1997. Psychopharmacology. 129: 285-288 A1 Journal article (refereed), original research -
The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer`s disease
Tapiola T, Overmyer M, Lehtovirta M, Helisalmi S, Ramberg J, Alafuzoff I, Riekkinen P Sr, Soininen H. 1997. Neuroreport. 8: 3961-3963 A1 Journal article (refereed), original research -
ApoE and Alzheimer`s disease-neuropathological, MRI and polpulation-based studies
Soininen H. Teoksessa: Salonen T, Sivenius J, Sirviö J, Riekkinen P Jr, Salminen A(toim.) , 1996. 20 Years of Brain Research in Kuopio. s. 37-40. Kuopio University, Department of Neuroscience and Neur... A3 Book section, Chapters in research books -
ApoE genotype and MRI volumetry: implication for therapy
Soininen HS, Lehtovirta M, Laakso MP, Partanen K, Riekkinen P Jr, Hallikainen M, Hänninen T, Koivisto K, Riekkinen PJ Sr. Teoksessa: Becker R, Giacobini E(toim.) , 1996. Alzheimer Disease: From Molecular Biology to Therapy. s. 475-480. Birkhäuser A3 Book section, Chapters in research books -
Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls
Pirttilä T, Soininen H, Heinonen O, Lehtimäki T, Bogdanovic N, Paljärvi L, Kosunen O, Winblad B, Riekkinen P Sr, Wisniewski HM, Mehta PD. 1996. Brain research. 722: 71-77 A1 Journal article (refereed), original research -
Apolipoprotein E epsilon4 allele - a risk factor for Alzheimer`s disease and hippocampal volume loss
Soininen H. 1996. TEKNIA JOURNAL. : 12-13 D1 Article in a trade journal -
Apolipoprotein E polymorphism in patients with different neurodegenerative disorders
Helisalmi S, Linnaranta K, Lehtovirta M, Mannermaa A, Heinonen O, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters. 205: 61-64 A1 Journal article (refereed), original research -
Apolipoprotein E, memory and Alzheimer's disease
Soininen HS, Riekkinen PJ Sr. 1996. Trends in neurosciences. 19: 224-228 A1 Journal article (refereed), original research -
Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex
Sorvari H, Soininen H, Pitkänen A. 1996. Neuroscience. 75: 421-443 A1 Journal article (refereed), original research -
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex
Sorvari H, Soininen H, Pitkänen A. 1996. Journal of comparative neurology. 369: 188-208 A1 Journal article (refereed), original research -
Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease
Pirttilä T, Mehta PD, Soininen H, Kim KS, Heinonen O, Paljärvi L, Kosunen O, Riekkinen P Sr, Wisniewski HM. 1996. Archives of neurology. 53: 189-193 A1 Journal article (refereed), original research -
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ Sr. 1996. Neurology. 46: 413-419 A1 Journal article (refereed), original research -
Diagnostic accuracy of Alzheimer's disease: a neuropathological study
Kosunen O, Soininen H, Paljärvi L, Heinonen O, Talasniemi S, Riekkinen PJ Sr. 1996. Acta neuropathologica. 91: 185-193 A1 Journal article (refereed), original research -
EEG reactivity correlates with neuropsychological test scores in Down's syndrome
Partanen J, Soininen H, Könönen M, Kilpeläinen R, Helkala E-L, Riekkinen P Sr. 1996. Acta neurologica scandinavica. 94: 242-246 A1 Journal article (refereed), original research -
Electrophysiological tests
Petit D, Montplaisir J, Riekkinen P Sr, Soininen H, Riekkinen P Jr. Teoksessa: Gauthier S(toim.) , 1996. Clinical Diagnosis and Management of Alzheimer's Disease. s. 107-126. Martin Duniz A3 Book section, Chapters in research books -
Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: an MRI study
Laakso MP, Partanen K, Riekkinen P Jr, Lehtovirta M, Helkala E-L, Hallikainen M, Hänninen T, Vainio P, Soininen H. 1996. Neurology. 46: 678-681 A1 Journal article (refereed), original research -
MR T2 relaxometry in Alzheimer's disease and age-associated memory impairment
Laakso MP, Partanen K, Soininen H, Lehtovirta M, Hallikainen M, Hänninen T, Helkala E-L, Vainio P, Riekkinen PJ Sr. 1996. Neurobiology of aging. 17: 535-540 A1 Journal article (refereed), original research -
Muistihäiriöt ja dementia
Suomen muistitutkimusyksiköiden asiantuntijaryhmä, Erkinjuntti T, Alhainen K, Frey H, Helkala E-L, Hervonen A, Hietanen M, Juva K, Kivelä S-L, Koponen H, Koivisto K, Majamaa K, Myllylä V, Pirttilä T, Reinikainen KJ, Riekkinen P Jr, Rinne J, Saarela T. 1996. Lääkärilehti. 51: 2949-2957 D1 Article in a trade journal -
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study
Sorvari H, Miettinen R, Soininen H, Pitkänen A. 1996. Neuroscience letters. 217: 93-96 A1 Journal article (refereed), original research -
Prevalence of ageing-associated cognitive decline in an elderly population
Hänninen T, Koivisto K, Reinikainen KJ, Helkala E-L, Soininen H, Mykkänen L, Laakso M, Riekkinen PJ. 1996. Age and ageing. 25: 201-205 A1 Journal article (refereed), original research -
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon4 allele
Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, Ryynänen M, Kuikka J, Hartikainen P, Riekkinen PJ Sr. 1996. Journal of neurology neurosurgery and psychiatry. 60: 644-649 A1 Journal article (refereed), original research -
Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters. 205: 68-70 A1 Journal article (refereed), original research -
Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease
Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H. 1996. Neurology. 46: 1724-1730 A1 Journal article (refereed), original research -
Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer`s disease patiens
Helkala E-L, Hänninen T, Könönen M, Hartikainen P, Partanen J, Partanen K, Vainio P, Hallikainen M, Laakso MP, Soininen H, Riekkinen P Sr. 1996. Behavioral neuroscience. 110: 1235-1243 A1 Journal article (refereed), original research -
Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Soininen H, Helisalmi S, Mannermaa A, Ryynänen M, Hartikainen P, Riekkinen P Sr. 1996. Neurobiology of aging. 17: 523-526 A1 Journal article (refereed), original research -
A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia
Hänninen T, Hallikainen M, Koivisto K, Helkala E-L, Reinikainen KJ, Soininen H, Mykkänen L, Laakso M, Pyörälä K, Riekkinen PJ Sr. 1995. Journal of the american geriatrics society. 43: 1007-1015 A1 Journal article (refereed), original research -
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein e4 allele
Soininen H, Kosunen O, Helisalmi S, Mannermaa A, Paljärvi L, Talasniemi S, Ryynänen M, Riekkinen P Sr. 1995. Neuroscience letters. 187: 79-82 A1 Journal article (refereed), original research -
Alzheimer pathology of patients carrying apolipoprotein E epsilon4 allele
Heinonen O, Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Sorvari H, Kosunen O, Paljärvi L, Ryynänen M, Riekkinen PJ Sr. 1995. Neurobiology of aging. 16: 505-513 A1 Journal article (refereed), original research -
Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland
Lehtovirta M, Helisalmi S, Mannermaa A, Soininen H, Koivisto K, Ryynänen M, Riekkinen P Sr. 1995. Neuroscience letters. 185: 13-15 A1 Journal article (refereed), original research -
Beta-amyloid-protein immunoreactivity in skin is not a reliable marker of Alzheimer's disease: an autopsy controlled study
Heinonen O, Soininen H, Syrjänen S, Neittaanmäki H, Paljärvi L, Kosunen O, Talasniemi S, Syrjänen K, Riekkinen P Sr. Teoksessa: Hanin I, Yoshida M, Fisher A(toim.) , 1995. Alzheimer's and Parkinson's Diseases. s. 157-163. Plenum Press A3 Book section, Chapters in research books -
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele
Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Neurology. 45: 391-392 A1 Journal article (refereed), original research -
Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex
Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1995. Journal of comparative neurology. 360: 185-212 A1 Journal article (refereed), original research -
Habituation of auditory N100 correlates with amygdaloid volumes and frontal functions in age-associated memory impairment
Soininen HS, Karhu J, Partanen J, Pääkkönen A, Jousmäki V, Hänninen T, Hallikainen M, Partanen K, Laakso MP, Koivisto K, Riekkinen PJ Sr. 1995. Physiology and behavior. 57: 927-935 A1 Journal article (refereed), original research -
Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease
Riekkinen P Jr, Soininen H, Helkala E-L, Partanen K, Laakso M, Vanhanen M, Riekkinen P. 1995. Neuroreport. 6: 1297-1300 A1 Journal article (refereed), original research -
Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele
Soininen H, Lehtovirta M, Helisalmi S, Linnaranta K, Heinonen O, Riekkinen P Sr. 1995. Neuroreport. 6: 2518-2520 A1 Journal article (refereed), original research -
Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease
Heinonen O, Soininen H, Sorvari H, Kosunen O, Paljärvi L, Koivisto E, Riekkinen PJ Sr. 1995. Neuroscience. 64: 375-384 A1 Journal article (refereed), original research -
MRI of amygdala fails to diagnose early Alzheimer's disease
Laakso MP, Partanen K, Lehtovirta M, Hallikainen M, Hänninen T, Vainio P, Riekkinen P Sr, Soininen H. 1995. Neuroreport. 6: 2414-2418 A1 Journal article (refereed), original research -
Regional cerebral blood flow measured by 99mTC-HMPAO SPECT differs in subgroups of Alzheimer's disease
Soininen H, Helkala E-L, Kuikka J, Hartikainen P, Lehtovirta M, Riekkinen PJ Sr. 1995. Journal of neural transmission. 9: 95-109 A1 Journal article (refereed), original research -
Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients
Kosunen O, Talasniemi S, Lehtovirta M, Heinonen O, Helisalmi S, Mannermaa A, Paljärvi L, Ryynänen M, Riekkinen PJ Sr, Soininen H. 1995. Stroke. 26: 743-748 A1 Journal article (refereed), original research -
Tetrahydroaminoacridine modulates technetium-99m labelled ethylene dicysteinate retention in Alzheimer's disease measured with single photon emission computed tomography imaging
Riekkinen P Jr, Kuikka J, Soininen H, Helkala E-L, Hallikainen M, Riekkinen P. 1995. Neuroscience letters. 195: 53-56 A1 Journal article (refereed), original research -
The interuncal distance in Alzheimer disease and age-associated memory impairment
Laakso M, Soininen H, Partanen K, Hallikainen M, Lehtovirta M, Hänninen T, Vainio P, Riekkinen PJ Sr. 1995. American journal of neuroradiology. 16: 727-734 A1 Journal article (refereed), original research -
Volumes of hippocampus and amygdala in the magnetic resonance imaging based diagnosis of early Alzheimer's disease
Laakso MP, Soininen H, Helkala E-L, Hartikainen P, Partanen K, Vainio P, Riekkinen PJ Sr. Teoksessa: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM(toim.) , 1995. Research Advances in Alzheimer's Disease and Related Disorders. s. 181-188. John Wiley A3 Book section, Chapters in research books -
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes
Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Partanen K, Ryynänen M, Vainio P, Hartikainen P, Riekkinen PJ Sr. 1995. Neuroscience. 67: 65-72 A1 Journal article (refereed), original research -
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions
Laakso MP, Soininen H, Partanen K, Helkala E-L, Hartikainen P, Vainio P, Hallikainen M, Hänninen T, Riekkinen PJ Sr. 1995. Journal of neural transmission. 9: 73-86 A1 Journal article (refereed), original research -
Interaction between genetic and environmental risk factors for Alzheimer's disease: A reanalysis of case-control studies
Van Duijn CM, Clayton DG, Chandra V, Fratiglioni L, Graves AB, Heyman A, Jorm AF, Kokmen E, Kondo K, Mortimer JA, Rocca WA, Shalat SL, Soininen H, Hofman A for the EURODEM Risk Factors Research Group. 1994. Genetic epidemiology. 11: 539-551 A1 Journal article (refereed), original research