Olli Gröhn
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
[email protected] | +358 50 359 0963
Publications
216/216 items-
fMRI data acquisition and analysis for task-free, anesthetized rats
Vrooman, Roël M.; van den Berg, Monica; Desrosiers-Gregoire, Gabriel; van Engelenburg, Wessel A.; Galteau, Marie E.; Lee, Sung-Ho; Veltien, Andor; Barrière, David A.; Cash, Diana; Chakravarty, M. Mallar; Devenyi, Gabriel A.; Gozzi, Alessandro; Gröhn, Olli; Hess, Andreas; Homberg, Judith R.; Jelescu, Ileana O.; Keliris, Georgios A.; Scheenen, Tom; Shih, Yen-Yu Ian; Verhoye, Marleen; Wary, Claire; Zwiers, Marcel; Grandjean, Joanes. 2025. Nature protocols. [Published: 28 January 2025]: 1-23 A2 Review article, Literature review, Systematic review -
ComBating inter‐site differences in field strength: harmonizing preclinical traumatic brain injury MRI data
Quach, Mara; Ali, Idrish; Shultz, Sandy R; Casillas‐Espinosa, Pablo M; Hudson, Matthew R; Jones, Nigel C; Silva, Juliana C; Yamakawa, Glenn R; Braine, Emma L; Immonen, Riikka; Staba, Richard J; Tohka, Jussi; Harris, Neil G; Gröhn, Olli; O'Brien, Terence J; Wright, David K. 2024. Nmr in biomedicine. 37: A1 Journal article (refereed), original research -
Modeling the stress and forces on multi-channel TMS coil arrays in high-field MRI scanners
Koponen, Maria A; Korhonen, Juuso T; Membrilla, Jose A Vilchez; Sinisalo, Heikki; Paasonen, Jaakko; Sanchez, Clemente Cobos; Gröhn, Olli; Ilmoniemi, Risto J; Souza, Victor H. 2024. Physics in medicine and biology. 69: A1 Journal article (refereed), original research -
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study
Heiskanen, Mette; Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Puhakka, Noora; Gupta, Shalini Das; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Manninen, Eppu; Smith, Gregory; Brady, Rhys D.; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R.; Jones, Nigel C.; Shultz, Sandy R.; Harris, Neil G.; Wright, David K.; Gröhn, Olli; Staba, Richard J.; O'Brien, Terence J.; Pitkänen, Asla. 2024. Epilepsia. [First published: 11 December 2024]: 1-16 A1 Journal article (refereed), original research -
Resting-state functional MRI of the nose as a novel investigational window into the nervous system
Ponticorvo, Sara; Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A.; Tanila, Heikki; Filip, Pavel; Rothman, Douglas L.; Eberly, Lynn E.; Garwood, Michael; Metzger, Gregory J.; Gröhn, Olli; Michaeli, Shalom; Mangia, Silvia. 2024. Scientific reports. 14: . 26352 A1 Journal article (refereed), original research -
Whole-brain responses to visual and auditory stimuli in anesthetized and minimally restrained awake mice using quiet zero echo time fMRI
Dvořáková, Lenka; Stenroos, Petteri; Salo, Raimo A.; Paasonen, Ekaterina; Tanila, Heikki; Michaeli, Shalom; Mangia, Silvia; Zehnder, Tamara; Mueggler, Thomas; Künnecke, Basil; Paasonen, Jaakko; Gröhn, Olli. 2024. Imaging neuroscience. 2: 1-16 A1 Journal article (refereed), original research -
A consensus protocol for functional connectivity analysis in the rat brain
Grandjean, Joanes; Desrosiers-Gregoire, Gabriel; Anckaerts, Cynthia; Angeles-Valdez, Diego; Ayad, Fadi; Barrière, David A.; Blockx, Ines; Bortel, Aleksandra; Broadwater, Margaret; Cardoso, Beatriz M.; Célestine, Marina; Chavez-Negrete, Jorge E.; Choi, Sangcheon; Christiaen, Emma; Clavijo, Perrin; Colon-Perez, Luis; Cramer, Samuel; Daniele, Tolomeo; Dempsey, Elaine; Diao, Yujian; Doelemeyer, Arno; Dopfel, David; Dvořáková, Lenka; Falfán-Melgoza, Claudia; Fernandes, Francisca F.; Fowler, Caitlin F. 2023. Nature neuroscience. 26: 673-681 A1 Journal article (refereed), original research -
Axon fiber orientation as the source of T1 relaxation anisotropy in white matter: A study on corpus callosum in vivo and ex vivo
Kauppinen, Risto A; Thothard, Jeromy; Leskinen, Henri PP; Pisharady, Pramod K; Manninen, Eppu; Kettunen, Mikko; Lenglet, Christophe; Gröhn, Olli HJ; Garwood, Michael; Nissi, Mikko J. 2023. Magnetic resonance in medicine. 90: 708-721 A1 Journal article (refereed), original research -
Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury
Chary, Karthik; Manninen, Eppu; Claessens, Jade; Ramirez-Manzanares, Alonso; Gröhn, Olli; Sierra, Alejandra. 2023. Scientific reports. 13: . 2219 A1 Journal article (refereed), original research -
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1
Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla. 2023. Epilepsia. 2024; 65: 511-526 A1 Journal article (refereed), original research -
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S. 2023. Epilepsy research. 195: A1 Journal article (refereed), original research -
Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala
Gureviciene, Irina; Laakso, Hanne; Narvaez, Omar; Paasonen, Ekaterina; Lehto, Lauri; Gurevicius, Kestutis; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli; Sierra, Alejandra; Tanila, Heikki. 2023. Frontiers in neuroscience. 17: . 1147547 A1 Journal article (refereed), original research -
Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies
Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla. 2023. Epilepsy research. 2024; 199: A1 Journal article (refereed), original research -
A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force
van Vliet, Erwin A.; Immonen, Riikka; Prager, Ofer; Friedman, Alon; Bankstahl, Jens P.; Wright, David K.; O'Brien, Terence J.; Potschka, Heidrun; Gröhn, Olli; Harris, Neil G.. 2022. Epilepsia open. [First published: 13 August 2022]: 1-47 A1 Journal article (refereed), original research -
Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury
Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research -
Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat
Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka. 2022. Brain research. 1788: A1 Journal article (refereed), original research -
Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury
De Feo, Riccardo; Hämäläinen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Frontiers in neurology. 13: . 820267 A1 Journal article (refereed), original research -
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat
Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli. 2022. Magnetic resonance in medicine. 87: 2872-2884 A1 Journal article (refereed), original research -
Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model
De Feo, Riccardo; Manninen, Eppu; Chary, Karthik; Hämäläinen, Elina; Immonen, Riikka; Andrade, Pedro; Ndode‐Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Epilepsia. 63: 1849-1861 A1 Journal article (refereed), original research -
Histopathological modeling of status epilepticus-induced brain damage based on in vivo diffusion tensor imaging in rats
San Martín Molina, Isabel; Salo, Raimo A.; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2022. Frontiers in neuroscience. 16: . 944432 A1 Journal article (refereed), original research -
MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains
Ndode-Ekane, Xavier Ekolle; Immonen, Riikka; Hämäläinen, Elina; Manninen, Eppu; Andrade, Pedro; Ciszek, Robert; Paananen, Tomi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research -
Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition
Wu, Lin; Canna, Antonietta; Narvaez, Omar; Ma, Jun; Sang, Sheng; Lehto, Lauri J.; Sierra, Alejandra; Tanila, Heikki; Zhang, Yuan; Gröhn, Olli; Low, Walter C.; Filip, Pavel; Mangia, Silvia; Michaeli, Shalom. 2022. Scientific reports. 12: . 8565 A1 Journal article (refereed), original research -
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research -
Relaxation anisotropy of quantitative MRI parameters in biological tissues
Hänninen, Nina Elina; Liimatainen, Timo; Hanni, Matti; Gröhn, Olli; Nieminen, Miika Tapio; Nissi, Mikko Johannes. 2022. Scientific reports. 12: . 12155 A1 Journal article (refereed), original research -
Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents
Sirmpilatze, Nikoloz; Mylius, Judith; Ortiz-Rios, Michael; Baudewig, Jürgen; Paasonen, Jaakko; Golkowski, Daniel; Ranft, Andreas; Ilg, Rüdiger; Gröhn, Olli; Boretius, Susann. 2022. eLife. 11: . e74813 A1 Journal article (refereed), original research -
State Estimation of Time-Varying MRI with Radial Golden Angle Sampling
Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko. 2022. Journal of mathematical imaging and vision. 64: 825-844 A1 Journal article (refereed), original research -
Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI
Paasonen, Jaakko; Stenroos, Petteri; Laakso, Hanne; Pirttimäki, Tiina; Paasonen, Ekaterina; Salo, Raimo A.; Tanila, Heikki; Idiyatullin, Djaudat; Garwood, Michael; Michaeli, Shalom; Mangia, Silvia; Gröhn, Olli. 2022. Neuroimage. 250: A1 Journal article (refereed), original research -
Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis
Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Epilepsia. 62: 1852-1864 A1 Journal article (refereed), original research -
Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases
De Feo, Riccardo; Shatillo, Artem; Sierra, Alejandra; Valverde, Juan Miguel; Gröhn, Olli; Giove, Federico; Tohka, Jussi. 2021. Neuroimage. 229: 117734 A1 Journal article (refereed), original research -
Brain fMRI during orientation selective epidural spinal cord stimulation
Canna, Antonietta; Lehto, Lauri J; Wu, Lin; Sang, Sheng; Laakso, Hanne; Ma, Jun; Filip, Pavel; Zhang, Yuan; Gröhn, Olli; Esposito, Fabrizio; Chen, Clark C; Lavrov, Igor; Michaeli, Shalom; Mangia, Silvia. 2021. Scientific reports. 11: 5504 A1 Journal article (refereed), original research -
Data-Driven Regularization Parameter Selection in Dynamic MRI
Hanhela, Matti; Gröhn, Olli; Kettunen, Mikko; Niinimäki, Kati; Vauhkonen, Marko; Kolehmainen, Ville. 2021. Journal of imaging. 7: 38 A1 Journal article (refereed), original research -
Infantile status epilepticus disrupts myelin development
Bencurova, Petra; Laakso, Hanne; Salo, Raimo A; Paasonen, Ekaterina; Manninen, Eppu; Paasonen, Jaakko; Michaeli, Shalom; Mangia, Silvia; Bares, Martin; Brazdil, Milan; Kubova, Hana; Gröhn, Olli. 2021. Neurobiology of disease. 2022; 162: 105566 A1 Journal article (refereed), original research -
Isoflurane affects brain functional connectivity in rats 1 month after exposure
Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Neuroimage. 234: 117987 A1 Journal article (refereed), original research -
Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats
Dvoráková, Lenka; Stenroos, Petteri; Paasonen, Ekaterina; Salo, Raimo A.; Paasonen, Jaakko; Gröhn, Olli. 2021. Nmr in biomedicine. 2022; 35: A1 Journal article (refereed), original research -
Metabolism of hyperpolarised [1-13C]pyruvate in awake and anaesthetised rat brains
Hyppönen, Viivi; Stenroos, Petteri; Nivajärvi, Riikka; Ardenkjaer-Larsen, Jan Henrik; Gröhn, Olli; Paasonen, Jaakko; Kettunen, Mikko I. 2021. Nmr in biomedicine. 2022; 35: e4635 A1 Journal article (refereed), original research -
Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury
Chary Karthik, Narvaez Omar, Salo Raimo A, San Martín Molina Isabel, Tohka Jussi, Aggarwal Manisha, Gröhn Olli, Sierra Alejandra. 2021. Frontiers in neuroscience. 15: 746214 A1 Journal article (refereed), original research -
Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury
Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Brain structure and function. 2022; 227: 145-158 A1 Journal article (refereed), original research -
RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats
Holikova, Klara; Laakso, Hanne; Salo, Raimo; Shatillo, Artem; Nurmi, Antti; Bares, Martin; Vanicek, Jiri; Michaeli, Shalom; Mangia, Silvia; Sierra, Alejandra; Gröhn, Olli. 2021. Frontiers in neuroscience. 15: 625167 A1 Journal article (refereed), original research -
Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification
Genicio, Nuria; Bañobre-López, Manuel; Gröhn, Olli; Gallo, Juan. 2021. Coordination chemistry reviews. 447: 214150 A2 Review article, Literature review, Systematic review -
Relaxation Anisotropy in Biological Tissues
Hänninen N; Nissi MJ; Hanni M; Gröhn OHJ; Nieminen MT; Liimatainen T. 2021. -
Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats
Laakso, Hanne; Lehto, Lauri J; Paasonen, Jaakko; Salo, Raimo; Canna, Antonietta; Lavrov, Igor; Michaeli, Shalom; Gröhn, Olli; Mangia, Silvia. 2021. Magnetic resonance in medicine. 86: 2137-2145 A1 Journal article (refereed), original research -
Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation
Miocchi, Paolo; Sierra, Alejandra; Maugeri, Laura; Stefanutti, Eleonora; Abdollahzadeh, Ali; Mangini, Fabio; Moraschi, Marta; Bukreeva, Inna; Massimi, Lorenzo; Brun, Francesco; Tohka, Jussi; Gröhn, Olli; Mittone, Alberto; Bravin, Alberto; Nicaise, Charles; Giove, Federico; Cedola, Alessia; Fratini, Michela. 2021. Physica medica. 81: 197-209 A1 Journal article (refereed), original research -
A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis
Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W. Teoksessa: -(toim.) , 2020. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). s. 1013-1017. IEEE A4 Conference proceedings -
Assessment of the structural complexity of diffusion MRI voxels using 3D electron microscopy in the rat brain
Salo, Raimo A; Belevich, Ilya; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2020. Neuroimage. 225: 117529 A1 Journal article (refereed), original research -
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate
Nivajärvi, R; Olsson, V; Hyppönen, V; Bowen, S; Leinonen, HM; Lesch, HP; Ardenkjaer-Larsen, JH; Gröhn, OHJ; Ylä-Herttuala, S; Kettunen, MI. 2020. Nmr in biomedicine. 33: e4250 A1 Journal article (refereed), original research -
Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury
Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Journal of neurotrauma. 37: 2580-2594 A1 Journal article (refereed), original research -
In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats
San Martín Molina, Isabel; Salo, Raimo A; Abdollahzadeh, Ali; Tohka, Jussi; Gröhn, Olli; Sierra, Alejandra. 2020. eNeuro. 7: ENEURO.0476-19.2020 A1 Journal article (refereed), original research -
Individual head models for estimating the TMS-induced electric field in rat brain
Koponen, Lari M; Stenroos, Matti; Nieminen, Jaakko O; Jokivarsi, Kimmo; Gröhn, Olli; Ilmoniemi, Risto J. 2020. Scientific reports. 10: 17397 A1 Journal article (refereed), original research -
Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury
van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Neurobiology of disease. 145: 1-20 A1 Journal article (refereed), original research -
Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat
Paasonen, J; Laakso, H; Pirttimäki, T; Stenroos, P; Salo, RA; Zhurakovskaya, E; Lehto, LJ; Tanila, H; Garwood, M; Michaeli, S; Idiyatullin, D; Mangia, S; Gröhn, O. 2020. Neuroimage. 206: 116338 A1 Journal article (refereed), original research -
Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective
Fratini, Michela; Abdollahzadeh, Ali; DiNuzzo, Mauro; Salo, Raimo; Maugeri, Laura; Cedola, Alessia; Giove, Federico; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2020. Frontiers in neuroscience. 14: 72 A2 Review article, Literature review, Systematic review -
Orientation selective deep brain stimulation of the subthalamic nucleus in rats
Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Neuroimage. 213: 116750 A1 Journal article (refereed), original research -
RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation
Valverde, Juan Miguel; Shatillo, Artem; De Feo, Riccardo; Gröhn, Olli; Sierra, Alejandra; Tohka, Jussi. 2020. Frontiers in neuroscience. 14: 610239 A1 Journal article (refereed), original research -
Temporal Huber Regularization for DCE-MRI
Hanhela, Matti; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko; Kolehmainen, Ville. 2020. Journal of mathematical imaging and vision. 62: 1334-1346 A1 Journal article (refereed), original research -
Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks
Valverde, JM; Shatillo, A; De Feo, R; Gröhn, O; Sierra, A; Tohka, J. Teoksessa: Suk, HI; Liu, M; Yan, P; Lian, C(toim.) , 2019. Machine Learning in Medical Imaging. MLMI 2019. s. 195-202. Springer A3 Book section, Chapters in research books -
Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain
Knight, MJ; Damion, RA; McGarry, BL; Bosnell, R; Jokivarsi, KT; Gröhn, OHJ; Jezzard, P; Harston, GWJ; Carone, D; Kennedy, J; El-Tawil, S; Elliot, J; Muir, KW; Clatworthy, P; Kauppinen, RA. 2019. Biomedical spectroscopy and imaging. 8: 11-28 A1 Journal article (refereed), original research -
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research. 150: 46-57 A1 Journal article (refereed), original research -
Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease
Zhurakovskaya, E; Ishchenko, I; Gureviciene, I; Aliev, R; Gröhn, O; Tanila, H. 2019. Scientific reports. 9: 5380 A1 Journal article (refereed), original research -
Lateral fluid-percussion injury leads to pituitary atrophy in rats
Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports. 9: 11819 A1 Journal article (refereed), original research -
MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study
Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. Frontiers in neuroscience. 13: 863 A1 Journal article (refereed), original research -
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Neuropharmacology. 149: 113-123 A1 Journal article (refereed), original research -
Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease
Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. eNeuro. 6: 1-12 A1 Journal article (refereed), original research -
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol
Vespa, PM; Shrestha, V; Abend, N; Agoston, D; Au, A; Bell, MJ; Bleck, TP; Blanco, MB; Claassen, J; Diaz-Arrastia, R; Duncan, D; Ellingson, B; Foreman, B; Gilmore, EJ; Hirsch, L; Hunn, M; Kamnaksh, A; McArthur, D; Morokoff, A; O'Brien, T; et al. (incl. Gröhn, Olli). 2019. Neurobiology of disease. 123: 110-114 A2 Review article, Literature review, Systematic review -
Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit
Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Frontiers in neuroscience. 12: 548 A1 Journal article (refereed), original research -
Clinical deep brain stimulation strategies for orientation-selective pathway activation
Slopsema, Julia P; Peña, Edgar; Patriat, Remi; Lehto, Lauri J; Gröhn, Olli; Mangia, Silvia; Harel, Noam; Michaeli, Shalom; Johnson, Matthew D. 2018. Journal of neural engineering. 15: 56029 A1 Journal article (refereed), original research -
Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury
Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Journal of neurotrauma. 35: 2708-2717 A1 Journal article (refereed), original research -
Dynamic MRI reconstruction from undersampled data with an anatomical prescan
Rasch, Julian; Kolehmainen, Ville; Nivajärvi, Riikka; Kettunen, Mikko; Grohn, Olli; Burger, Martin; Brinkmann, Eva-Maria. 2018. Inverse problems. 34: 74001 A1 Journal article (refereed), original research -
Functional connectivity under six anesthesia protocols and the awake condition in rat brain
Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A; Kiviniemi, Vesa; Gröhn Olli. 2018. Neuroimage. 172: 9-20 A1 Journal article (refereed), original research -
Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers
Immonen, Riikka; Harris, Neil G; Wright, David; Johnston, Leigh; Manninen, Eppu; Smith, Gregory; Paydar, Afshin; Branch, Craig; Grohn Olli. 2018. Neurobiology of disease. 2019; 123: 75-85 A2 Review article, Literature review, Systematic review -
Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain
Salo, Raimo A; Belevich, Ilya; Manninen, Eppu; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2018. Neuroimage. 172: 404-414 A1 Journal article (refereed), original research -
Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging
Shatillo, A; Lipponen, A; Salo, RA; Tanila, H; Verkhratsky, A; Giniatullin, R; Gröhn, OH. 2018. Journal of cerebral blood flow and metabolism. 2019; 39: 1949-1960 A1 Journal article (refereed), original research -
State estimation in dynamic MRI
Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Huttunen, Joanna; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko. Teoksessa: -(toim.) , 2018. 2018 IEEE Nuclear Science Symposium and Medical Imaging (NSS/MIC): Conference Proceedings. s. 1-6. IEEE A4 Conference proceedings -
Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex
Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Frontiers in neuroscience. 12: 899 A1 Journal article (refereed), original research -
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
McGarry BL, Jokivarsi KT, Knight MJ, Grohn OHJ, Kauppinen RA. 2017. Journal of visualized experiments. 127: 1-6 A1 Journal article (refereed), original research -
Conceptual Design of Flex-DBS, a Mechanically Reconfigurable Deep Brain Stimulation Probe
Johnson G, Lehto L, Mangia S, Gröhn O, Michaeli S, Kodandaramaiah S. Teoksessa: -(toim.) , 2017. Proceedings of the 2017 Design of Medical Devices Conference. s. V001T02A001. American Society of Mechanical Engineers A4 Conference proceedings -
Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis
Salo RA, Miettinen T, Laitinen T, Gröhn O, Sierra A. 2017. Neuroimage. 152: 221-236 A1 Journal article (refereed), original research -
Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat
Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Neuropharmacology. 119: 15-25 A1 Journal article (refereed), original research -
In Vivo Imaging in Rodents
Gröhn O, Deleye S, Bertoglio D, Dedeurwaerdere S. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL(toim.) , 2017. Models of Seizures and Epilepsy (Second Edition). s. 197-215. Elsevier A3 Book section, Chapters in research books -
Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame
Lehto Lauri J, Albors Aloma A. Sierra Alejandra, Tolppanen Laura, Eberly Lynn E, Mangia Silvia, Nurmi Antti, Michaeli Shalom, Gröhn Olli. 2017. Frontiers in neuroscience. 11: 433 A1 Journal article (refereed), original research -
MB-SWIFT functional MRI during deep brain stimulation in rats
Lehto Lauri J, Idiyatullin Djaudat, Zhang Jinjin, Utecht Lynn, Adriany Gregor, Garwood Michael, Gröhn Olli, Michaeli Shalom, Mangia Silvia. 2017. Neuroimage. 159: 443-448 A1 Journal article (refereed), original research -
Magnetization transfer SWIFT MRI consistently detects histologically verified myelin loss in the thalamocortical pathway after a traumatic brain injury in rat
Lehto LJ, Sierra A, Gröhn O. 2017. Nmr in biomedicine. 30: e3678 A1 Journal article (refereed), original research -
Neuroimaging in animal models of epilepsy
Bertoglio Daniele, Verhaeghe Jeroen, Dedeurwaerdere Stefanie, Gröhn Olli. 2017. Neuroscience. 358: 277-299 A1 Journal article (refereed), original research -
Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM)
Aggarwal M, Li X, Gröhn O, Sierra A. 2017. Journal of magnetic resonance imaging. 2018; 47: 554-564 A1 Journal article (refereed), original research -
Orientation selective deep brain stimulation
Lehto Lauri J, Slopsema Julia P, Johnson Matthew D, Shatillo Artem, Teplitzky Benjamin A, Utecht Lynn, Adriany Gregor, Mangia Silvia, Sierra Alejandra, Low Walter C, Gröhn Olli, Michaeli Shalom. 2017. Journal of neural engineering. 14: 16016 A1 Journal article (refereed), original research -
Searching for epilepsy's crystal ball
Gröhn Olli, Sierra Alejandra. 2017. eLife. 6: e29853 A1 Journal article (refereed), original research -
State Estimation with Structural Priors in fMRI
Wettenhovi Ville-Veikko, Kolehmainen Ville, Huttunen Joanna, Kettunen Mikko, Gröhn Olli, Vauhkonen Marko. 2017. Journal of mathematical imaging and vision. 2018; 60: 174-188 A1 Journal article (refereed), original research -
Stroke onset time determination using MRI relaxation times without non-ischaemic reference in a rat stroke model
Norton Terence JT, Pereyra Marcelo, Knight Michael J, McGarry Bryony M, Jokivarsi Kimmo T, Grohn Olli HJ, Kauppinen Risto A. 2017. Biomedical spectroscopy and imaging. 6: 25-35 A1 Journal article (refereed), original research -
A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: application and validation in a rat acute stroke model
Knight MJ, Mcgarry BL, Rogers HJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Journal of cerebral blood flow and metabolism. 36: 1232-1243 A1 Journal article (refereed), original research -
Advances in the development of biomarkers for epilepsy
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. The Lancet Neurology. 15: 843-856 A2 Review article, Literature review, Systematic review -
Common data elements and data management: Remedy to cure underpowered preclinical studies
Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Epilepsy research. 129: 87-90 A1 Journal article (refereed), original research -
Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat
Paasonen Jaakko, Salo Raimo A, Shatillo Artem, Forsberg Markus M, Närväinen Johanna, Huttunen Joanna K, Gröhn Olli. 2016. European neuropsychopharmacology. 26: 518-531 A1 Journal article (refereed), original research -
Determining stroke onset time using quantitative MRI: High accuracy, sensitivity and specificity obtained from magnetic resonance relaxation times
McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Cerebrovascular diseases extra. 6: 60-65 A1 Journal article (refereed), original research -
Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage
Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. 2016. Osteoarthritis and cartilage. 24: 1656-1664 A1 Journal article (refereed), original research -
Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI
Zhurakovskaya Ekaterina, Paasonen Jaakko, Shatillo Artem, Lipponen Arto, Salo Raimo, Aliev Raimo, Tanila Heikki, Gröhn Olli. 2016. PLoS ONE. 11: e0155343 A1 Journal article (refereed), original research -
Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents
Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 A1 Journal article (refereed), original research -
Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia
Vieites-Prado Alba, Iglesias-Rey Ramón, Fernández-Susavila Héctor, da Silva-Candal Andrés, Rodríguez-Castro Emilio, Gröhn Olli HJ, Wellmann Sven, Sobrino Tomás, Castillo José, Campos Francisco. 2016. Stroke. 47: 2386-2396 A1 Journal article (refereed), original research -
Resting-state functional MRI as a tool for evaluating brain hemodynamic responsiveness to external stimuli in rats
Paasonen Jaakko, Salo Raimo A, Huttunen Joanna K, Gröhn Olli. 2016. Magnetic resonance in medicine. 78: 1136-1146 A1 Journal article (refereed), original research -
Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia
McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Sierra A, Gröhn OHJ, Kauppinen RA. 2016. International journal of stroke. 11: 677-82 A1 Journal article (refereed), original research -
Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo
Nissinen Tuomo, Näkki Simo, Laakso Hanne, Kuciauskas Dalius, Kaupinis Algirdas, Kettunen Mikko I, Liimatainen Timo, Hyvönen Mervi, Valius Mindaugas, Gröhn Olli, Lehto Vesa-Pekka. 2016. Acs applied materials and interfaces. 8: 32723-32731 A1 Journal article (refereed), original research -
Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in AßPP/PS1 mice both in vivo and ex vivo
Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki. 2015. Journal of Alzheimer's disease. 46: 926-946 A1 Journal article (refereed), original research -
Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat
Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Frontiers in neuroscience. 9: 12 p A1 Journal article (refereed), original research -
Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model
Heidi Marjonen, Alejandra Sierra, Anna Nyman, Vladimir Rogojin, Olli Gröhn, Anni-Maija Linden, Sampsa Hautaniemi, Nina Kaminen-Ahola. 2015. PLoS ONE. 10: e0124931 A1 Journal article (refereed), original research -
Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis
Sierra A, Gröhn O, Pitkänen A. 2015. Neuroscience. 309: 162-172 A2 Review article, Literature review, Systematic review -
Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI
Shatillo Artem, Salo Raimo A, Giniatullin Rashid, Gröhn Olli H. 2015. Neuropharmacology. 93: 164-170 A1 Journal article (refereed), original research -
Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats
Levijoki Jouko, Kivikko Matti, Pollesello Piero, Sallinen Jukka, Hyttilä-Hopponen Minja, Kuoppamäki Mikko, Haasio Kristiina, Gröhn Olli, Miettinen Riitta, Puoliväli Jukka, Tähtivaara Leena, Yrjänheikki Juha, Haapalinna Antti. 2015. European journal of pharmacology. 750: 132-140 A1 Journal article (refereed), original research -
MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain
Hakkarainen Hanne, Sierra Alejandra, Mangia Silvia, Garwood Michael, Michaeli Shalom, Gröhn Olli, Liimatainen Timo. 2015. Magnetic resonance in medicine. first published online: 3 FEB 2015: 8 p A1 Journal article (refereed), original research -
Phase imaging in brain using SWIFT
Lehto Lauri Juhani, Garwood Michael, Grohn Olli, Corum Curtis Andrew. 2015. Journal of magnetic resonance. 252: 20-28 A1 Journal article (refereed), original research -
Decreased resting functional connectivity after traumatic brain injury in the rat
Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. PLoS ONE. 2014 Apr 18;9(4): e95280 A1 Journal article (refereed), original research -
Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats
Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Epilepsy research. 2014 May;108(4): 653-65 A1 Journal article (refereed), original research -
Facile synthesis of biocompatible superparamagnetic mesoporous nanoparticles for imageable drug delivery
Nissinen Tuomo, Näkki Simo, Latikka Mika, Heinonen Markku, Liimatainen Timo, Xu Wujun, Ras Robin HA, Gröhn Olli, Riikonen Joakim, Lehto Vesa-Pekka. 2014. Microporous and mesoporous materials. 195: 2-8 A1 Journal article (refereed), original research -
Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging
Teplov Victor, Shatillo Artem, Nippolainen Ervin, Gröhn Olli, Giniatullin Rashid, Kamshilin Alexei A. 2014. Journal of biomedical optics. 19: 046011-1-9 A1 Journal article (refereed), original research -
Measurement of T1 relaxation time of osteochondral specimens using VFA-SWIFT
Nissi Mikko J, Lehto Lauri J, Corum Curtis A, Idiyatullin Djaudat, Ellermann Jutta M, Gröhn Olli HJ, Nieminen Miika T. 2014. Magnetic resonance in medicine. -: - A1 Journal article (refereed), original research -
Opposite reactivity of meningeal versus cortical microvessels to the nitric oxide donor glyceryl trinitrate evaluated in vivo with two-photon imaging
Pryazhnikov E, Kislin M, Tibeykina M, Toptunov D, Ptukha A, Shatillo A, Gröhn O, Giniatullin R, Khiroug L. 2014. PLoS ONE. 2014 Feb 28;9(2):e89699: e89699 A1 Journal article (refereed), original research -
Parenchymal spin-lock fMRI signals associated with cortical spreading depression
Autio JA, Shatillo A, Giniatullin R, Gröhn OH. 2014. Journal of cerebral blood flow and metabolism. 34: 768-775 A1 Journal article (refereed), original research -
Posttraumatic epilepsy - Disease or comorbidity?
Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior. 2014 Feb 11.: -- A2 Review article, Literature review, Systematic review -
Progressive volume loss and white matter degeneration in cstb-deficient mice: a diffusion tensor and longitudinal volumetry MRI study
Manninen O, Laitinen T, Lehtimäki KK, Tegelberg S, Lehesjoki AE, Gröhn O, Kopra O. 2014. PLoS ONE. 2014 Mar 6;9(3):e90709.: e90709 A1 Journal article (refereed), original research -
Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities
Rogers Harriet J, McGarry Bryony L, Knight Michael J, Jokivarsi Kimmo T, Gröhn Olli H, Kauppinen Risto A. 2014. Neuroreport. 2014 Oct 22;25(15): 1180-1185 A1 Journal article (refereed), original research -
Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities
Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S. 2014. American journal of physiology : heart and circulatory physiology. 307: H1226-H1232 A1 Journal article (refereed), original research -
Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system
Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M, Gu C, Khazipov R, Davletov B, Grohn O, Giniatullin R. 2013. Neuroscience. 2013 Sep 11;253C: 341-349 A1 Journal article (refereed), original research -
Diffusion tensor imaging of hippocampal network plasticity
Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Brain structure and function. 220: 781-801 A1 Journal article (refereed), original research -
In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders
Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A. 2013. International journal of cancer. 6 DEC 2013: -- A1 Journal article (refereed), original research -
MRI biomarkers for post-traumatic epileptogenesis.
Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. Journal of neurotrauma. 2013 Jul 15;30(14): 1305-9 A1 Journal article (refereed), original research -
Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI
Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Journal of neurotrauma. : 546-56 A1 Journal article (refereed), original research -
Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI) in Permanent Focal Cerebral Ischemia in Rat
Jokivarsi KT, Liimatainen T, Kauppinen RA, Gröhn OH, Närväinen J. 2013. PLoS ONE. 2013 Jul 17;8(7):e69157: -- A1 Journal article (refereed), original research -
White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B-Deficient Mice
Manninen O, Koskenkorva P, Lehtimäki KK, Hyppönen J, Könönen M, Laitinen T, Kalimo H, Kopra O, Kälviäinen R, Gröhn O, Lehesjoki AE, Vanninen R. 2013. Radiology. : -- A1 Journal article (refereed), original research -
Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT
Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Neuroimage. 2012 Jul 16;61(4): 761-72 A1 Journal article (refereed), original research -
Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo
Musthafa HS, Dragneva G, Lottonen L, Merentie M, Petrov L, Heikura T, Ylä-Herttuala E, Ylä-Herttuala S, Gröhn O, Liimatainen T. 2012. Magnetic resonance in medicine. 2012 Jun 26: -- A1 Journal article (refereed), original research -
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses
Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Journal of nutrition health and aging. 16: 631-635 A1 Journal article (refereed), original research -
Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions
Torvinen S, Silvennoinen M, Piitulainen H, Närväinen J, Tuunanen P, Gröhn O, Koch LG, Britton SL, Kainulainen H. 2012. PLoS ONE. 2012;7(11):e48345: -- A1 Journal article (refereed), original research -
Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures
Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Epilepsia. 2012 Jul;53(7): 1245-53 A1 Journal article (refereed), original research -
Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia
Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Journal of cerebral blood flow and metabolism. 31: 1119-1132 A1 Journal article (refereed), original research -
Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat
Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Brain structure and function. 216: 123-135 A1 Journal article (refereed), original research -
Evoked local field potentials can explain temporal variation in blood oxygenation level-dependent responses in rat somatosensory cortex
Huttunen Joanna K, Niskanen Juha-Pekka, Lehto Lauri J, Airaksinen Antti M, Niskanen Eini I, Penttonen Markku, Gröhn Olli. 2011. Nmr in biomedicine. 24: 209-215 A1 Journal article (refereed), original research -
Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8(mnd) : implications to delayed myelination and oligodendrocyte maturation
Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O. 2011. Neuropathology and applied neurobiology. 2012 Aug;38(5): 471-86 A1 Journal article (refereed), original research -
Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67: 269-277, 2012
Liimatainen T, Sierra A, Hanson T, Sorce DJ, Ylä-Herttuala S, Garwood M, Michaeli S, Gröhn O. 2011. Magnetic resonance in medicine. 2012 Jan;67(1): 269-277 A1 Journal article (refereed), original research -
Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats
Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Journal of cerebral blood flow and metabolism. 31: 166-177 A1 Journal article (refereed), original research -
Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain
Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Epilepsia. : 57-60 B1 Non-refereed journal articles -
VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2011. Cancer gene therapy. 18: 100-9 A1 Journal article (refereed), original research -
Association of chronic vascular changes with functional outcome after traumatic brain injury in rats
Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Journal of neurotrauma. 27: 2203-2219 A1 Journal article (refereed), original research -
Cerebral blood volume alterations in the perilesional areas in the rat brain after traumatic brain injury¿comparison with behavioral outcome
Immonen R, Heikkinen T, Tähtivaara L, Nurmi A, Stenius TK, Puoliväli J, Tuinstra T, Phinney AL, Van Vliet B, Yrjänheikki J et al. 2010. Journal of cerebral blood flow and metabolism. 30: 1318 -1328 A1 Journal article (refereed), original research -
Correlating tissue outcome with quantitative multiparametric MRI of acute cerebral ischemia in rats
Jokivarsi KT, Hiltunen Y, Tuunanen PI, Kauppinen RA & Gröhn OH. 2010. Journal of cerebral blood flow and metabolism. 30: 415-427 A1 Journal article (refereed), original research -
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. 2010. Cancer gene therapy. 18: 100-109 A1 Journal article (refereed), original research -
Diffusion tensor MRI of axonal plasticity in the rat hippocampus
Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Neuroimage. 51: 251-530 A1 Journal article (refereed), original research -
Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats
Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Neuroscience letters. 484: 39-42 A1 Journal article (refereed), original research -
Estimation of the onset time of cerebral ischemia using T1rho and T2 MRI in rats
Jokivarsi KT, Hiltunen Y, Gröhn H, Tuunanen P, Gröhn OH & Kauppinen RA. 2010. Stroke. 41: 2335-2340 A1 Journal article (refereed), original research -
NMR relaxation times of trabecular bone - reproducibility, relationships to tissue structure and effects of sample freezing
Prantner V, Isaksson H, Närväinen J, Lammentausta E, Nissi MJ, Avela J, Gröhn OH, Jurvelin JS. 2010. Physics in medicine and biology. 55(2010): 1-13 A1 Journal article (refereed), original research -
Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence
Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Magnetic resonance in medicine. 64: 1191-1199 A1 Journal article (refereed), original research -
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy
Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Neuroscience. 166: 312-332 A1 Journal article (refereed), original research -
(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery
Kaikkonen MU, Lesch HP, Pikkarainen J, Räty JK, Vuorio T, Huhtala T, Taavitsainen M, Laitinen T, Tuunanen P, Gröhn O, Närvänen A, Airenne KJ, Ylä-Herttuala S. 2009. Gene therapy. 16: 894-904 A1 Journal article (refereed), original research -
Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up
Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Experimental neurology. 215: 29-40 A1 Journal article (refereed), original research -
From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options
Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. EPILEPSIA. SUPPLEMENT. 50: 21-29 A2 Review article, Literature review, Systematic review -
Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury
Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Neuroimage. 45: 1-9 A1 Journal article (refereed), original research -
Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Experimental neurology. 217: 154-164 A1 Journal article (refereed), original research -
Quantitative assessment of water pools by T1rho and T2rho MRI in acute cerebral ischemia of the rat
Jokivarsi KT, Niskanen J-P, Michaeli S, Gröhn HI, Garwood M, Kauppinen RA, Gröhn OH. 2009. Journal of cerebral blood flow and metabolism. 29: 206-216 A1 Journal article (refereed), original research -
1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo
Liimatainen TJ, Erkkilä AT, Valonen P, Vidgren H, Lakso M, Wong G, Gröhn OHJ, Ylä-Herttuala S, Hakumäki JM. 2008. Magnetic resonance in medicine. 59: 1232-1238 A1 Journal article (refereed), original research -
A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease
Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. Biochemical and biophysical research communications. 375: 356-361 A1 Journal article (refereed), original research -
Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex
Huttunen JK, Gröhn O, Penttonen M. 2008. Neuroimage. 39: 775-785 A1 Journal article (refereed), original research -
High-resolution ultrasound perfusion imaging of therapeutic angiogenesis
Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn OH, Ylä-Herttuala S. 2008. JACC : cardiovascular imaging. 1: 83 - 91 A1 Journal article (refereed), original research -
Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat
Parry-Jones AR, Liimatainen T, Kauppinen RA, Gröhn OH, Rothwell NJ. 2008. Magnetic resonance in medicine. 59: 1239-1249 A1 Journal article (refereed), original research -
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus
Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Neuroimage. 40: 1718-1730 A1 Journal article (refereed), original research -
T2, Carr-Purcell T2 and T1rho of fat and water as surrogate markers of trabecular bone structure
Lammentausta E, Silvast TS, Närväinen J, Jurvelin JS, Nieminen MT, Gröhn OHJ. 2008. Physics in medicine and biology. 53: 543-555 A1 Journal article (refereed), original research -
Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs
Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Gröhn OH, Ylä-Herttuala S. 2008. Cardiovascular research. 80: 263-270 A1 Journal article (refereed), original research -
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho
Sierra A, Michaeli S, Niskanen J-P, Valonen PK, Gröhn HI, Ylä-Herttuala S, Garwood M, Gröhn OH. 2008. Magnetic resonance in medicine. 59: 1311-1319 A1 Journal article (refereed), original research -
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle
Kholová I, Koota S, Kaskenpää N, Leppänen P, Närväinen J, Kavec M, Rissanen TT, Hazes T, Korpisalo P, Gröhn O, Ylä-Herttuala S. 2007. Human gene therapy. 18: 232-244 A1 Journal article (refereed), original research -
Epileptogenesis in experimental models
Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. EPILEPSIA. SUPPLEMENT. 48: 13-20 A1 Journal article (refereed), original research -
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma
Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OHJ. 2007. Radiology. 243: 796-803 A1 Journal article (refereed), original research -
Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations
Gröhn O, Pitkänen A. 2007. EPILEPSIA. SUPPLEMENT. 48: 3-10 A1 Journal article (refereed), original research -
Non-invasive imaging in gene therapy
Räty JK, Liimatainen T, Kaikkonen MU, Gröhn O, Airenne KJ, Ylä-Herttuala S. 2007. Molecular therapy. 15: 1579-1586 A2 Review article, Literature review, Systematic review -
Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia
Jokivarsi KT, Gröhn HI, Gröhn OH, Kauppinen RA. 2007. Magnetic resonance in medicine. 57: 647-653 A1 Journal article (refereed), original research -
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Brain. 130: 3155-3168 A1 Journal article (refereed), original research -
Spectroscopic imaging with volume selection by unpaired adiabatic pi pulses: Theory and application
Valette J, Park J-Y, Gröhn O, Ugurbil K, Garwood M, Henry P-G. 2007. Journal of magnetic resonance. 189: 1-12 A1 Journal article (refereed), original research -
Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions
Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Neuroscience letters. 428: 99-102 A1 Journal article (refereed), original research -
Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia
Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Free radical biology and medicine. 40: 1776-1784 A1 Journal article (refereed), original research -
Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo
Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Neuroimage. 30: 130-135 A1 Journal article (refereed), original research -
Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy
Liimatainen T, Hakumäki J, Tkác I, Gröhn O. 2006. Nmr in biomedicine. 19: 554-559 A1 Journal article (refereed), original research -
Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis
Rissanen TT, Korpisalo P, Markkanen JE, Liimatainen T, Ordén M-R, Kholová I, de Goede A, Heikura T, Gröhn OH, Ylä-Herttuala S. 2005. Circulation. 112: 3937-3946 A1 Journal article (refereed), original research -
Dispersion of cerebral on-resonance T1 in the rotating frame (T1 rho) in global ischaemia
Kettunen MI, Kauppinen RA, Gröhn OHJ. 2005. Applied magnetic resonance. 29: 89-106 A1 Journal article (refereed), original research -
Dynamic dephasing changes in developing ischemic cerebral infarction in rats studied by Carr-Purcell T2 magnetic resonance imaging
Kavec M, Gröhn OHJ, Gröhn HI, Garwood M, Kauppinen RA. 2005. Magnetic resonance in medicine. 53: 960-964 A1 Journal article (refereed), original research -
Exchange-influenced T2rho contrast in human brain images measured with adiabatic radio frequency pulses
Michaeli S, Gröhn H, Gröhn O, Sorce DJ, Kauppinen R, Springer CS Jr, Ugurbil K, Garwood M. 2005. Magnetic resonance in medicine. 53: 823-829 A1 Journal article (refereed), original research -
Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain
Pitkänen A, Gröhn O. 2005. Epilepsy currents -
High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma
Valonen PK, Griffin JL, Lehtimäki KK, Liimatainen T, Nicholson JK, Gröhn OHJ, Kauppinen RA. 2005. Nmr in biomedicine. 18: 252-259 A1 Journal article (refereed), original research -
Quantitative T(1rho) and adiabatic Carr-Purcell T2 magnetic resonance imaging of human occipital lobe at 4 T
Gröhn HI, Michaeli S, Garwood M, Kauppinen RA, Gröhn OHJ. 2005. Magnetic resonance in medicine. 54: 14-19 A1 Journal article (refereed), original research -
Tumour gene therapy monitoring using magnetic resonance imaging and spectroscopy
Kettunen MI, Gröhn OHJ. 2005. Current gene therapy. 5: 685-696 A1 Journal article (refereed), original research -
Acute cerebral ischemia in rats studied by Carr-Purcell spin-echo magnetic resonance imaging: Assessment of blood oxygenation level-dependent and tissue effects on the transverse relaxation
Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Garwood M, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 1138-1146 A1 Journal article (refereed), original research -
B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo
Mäkelä HI, De Vita E, Gröhn OHJ, Kettunen MI, Kavec M, Lythgoe M, Garwood M, Ordidge R, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 4-8 A1 Journal article (refereed), original research -
In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent
Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, Adriany G, Gröhn OHJ, Grimm R, Poduslo JF. 2004. Magnetic resonance in medicine. 52: 1263-1271 A1 Journal article (refereed), original research -
Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy
Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Epilepsia. 45: 1024-1034 A1 Journal article (refereed), original research -
Quantitative T1rho NMR spectroscopy of rat cerebral metabolites in vivo: Effects of global ischemia
Kettunen MI, Gröhn OHJ, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 875-880 A1 Journal article (refereed), original research -
Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density
Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Gröhn OHJ, Ylä-Herttuala S, Kauppinen RA. 2004. Journal of magnetic resonance imaging. 19: 389-396 A1 Journal article (refereed), original research -
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death
Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Cancer research. 63: 3195-3201 A1 Journal article (refereed), original research -
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*
Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. 2003. Journal of biological chemistry. 278: 45915-45923 A1 Journal article (refereed), original research -
Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma
Gröhn OHJ, Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Ylä-Herttuala S, Kauppinen RA, Garwood M. 2003. Cancer research. 63: 7571-7574 A1 Journal article (refereed), original research -
On- and off-resonance T1rho MRI in acute cerebral ischemia of the rat
Gröhn OHJ, Mäkelä HI, Lukkarinen JA, DelaBarre L, Lin J, Garwood M, Kauppinen RA. 2003. Magnetic resonance in medicine. 49: 172-176 A1 Journal article (refereed), original research -
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice
Kaasinen SK, Gröhn OHJ, Keinänen TA, Alhonen L, Jänne J. 2003. Experimental neurology. 183: 645-652 A1 Journal article (refereed), original research -
Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained
Kuhmonen J, Lukkarinen J, Gröhn O, Jolkkonen J, Sivenius J. 2002. Journal of pharmacy and pharmacology. 54: 1565-1569 A1 Journal article (refereed), original research -
Early gene therapy - induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame
Hakumäki JM, Gröhn OHJ, Tyynelä K, Valonen P, Ylä-Herttuala S, Kauppinen RA. 2002. Cancer gene therapy. 9: 338-345 A1 Journal article (refereed), original research -
Effects of intracellular pH, blood, and tissue oxygen tension on T-1rho relaxation in rat brain
Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Magnetic resonance in medicine. 48: 470-477 A1 Journal article (refereed), original research -
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. Teoksessa: Sutula T, Pitkänen A(toim.) , 2002. Do Seizures Damage the Brain. s. 67-83. Elsevier A3 Book section, Chapters in research books -
Quantitative T (1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat
Mäkelä HI, Kettunen MI, Gröhn OHJ, Kauppinen RA. 2002. Journal of cerebral blood flow and metabolism. 22: 547-558 A1 Journal article (refereed), original research -
Quantitative assessment of the balance between oxygen delivery and consumption in the rat brain after transient ischemia with T2-BOLD magnetic resonance imaging
Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Journal of cerebral blood flow and metabolism. 22: 262-270 A1 Journal article (refereed), original research -
Assessment of brain tissue viability in acute ischemic stroke by BOLD NMR
Gröhn OHJ, Kauppinen RA. 2001. Nmr in biomedicine. 14: 432-440 D1 Article in a trade journal -
Cerebral T1rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization
Kettunen MI, Gröhn OHJ, Penttonen M, Kauppinen RA. 2001. Magnetic resonance in medicine. 46: 565-572 A1 Journal article (refereed), original research -
Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions
Mäkelä HI, Gröhn OHJ, Kettunen MI, Kauppinen RA. 2001. Biochemical and biophysical research communications. 289: 813-818 A1 Journal article (refereed), original research -
Use of spin echo T2 BOLD in assessment of cerebral misery perfusion at 1.5 T
Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2001. Magnetic resonance materials in physics biology and medicine. 12: 32-39 A1 Journal article (refereed), original research -
Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho
Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 1457-1466 A1 Journal article (refereed), original research -
Graded reduction of cerebral blood flow in rat as detected by the nuclear magnetic resonance relaxation time T2: a theoretical and experimental approach
Gröhn OHJ, Kettunen MI, Penttonen M, Oja JME, van Zijl PCM, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 316-326 A1 Journal article (refereed), original research -
Interrelations of T1 and diffusion of water in acute cerebral ischemia of the rat
Kettunen MI, Gröhn OHJ, Lukkarinen JA, Vainio P, Silvennoinen MJ, Kauppinen RA. 2000. Magnetic resonance in medicine. 44: 833-839 A1 Journal article (refereed), original research -
Magnetic Resonance Imaging of Acute Cerebral Ischaemia. Novel Haemodynamic and Parenchymal Indicators of Reversible and Irreversible Ischaemia
Gröhn O. 2000. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet G5 Doctoral dissertation (article) -
Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia
Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Molecular and cellular neuroscience. 16: 87-96 A1 Journal article (refereed), original research -
Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat
Lukkarinen JA, Gröhn OHJ, Alhonen LI, Jänne J, Kauppinen RA. 1999. Brain research. 826: 325-329 A1 Journal article (refereed), original research -
Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame
Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Magnetic resonance in medicine. 42: 268-276 A1 Journal article (refereed), original research -
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging
Poptani H, Puumalainen A-M, Gröhn OH, Loimas S, Kainulainen R, Ylä-Herttuala S, Kauppinen RA. 1998. Cancer gene therapy. 5: 101-109 A1 Journal article (refereed), original research -
Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats
Lukkarinen JA, Kauppinen RA, Gröhn OHJ, Oja JME, Sinervirta R, Järvinen A, Alhonen LI, Jänne J. 1998. European journal of neuroscience. 10: 2046-2055 A1 Journal article (refereed), original research -
Noninvasive detection of cerebral hypoperfusion and reversible ischemia from reductions in the magnetic resonance imaging relaxation time, T2
Gröhn OHJ, Lukkarinen JA, Oja JME, van Zijl PCM, Ulatowski JA, Traystman RJ, Kauppinen RA. 1998. Journal of cerebral blood flow and metabolism. 18: 911-920 A1 Journal article (refereed), original research -
Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion
Lukkarinen J, Gröhn OHJ, Sinervirta R, Järvinen A, Kauppinen RA, Jänne J, Alhonen LI. 1997. Stroke. 28: 639-645 A1 Journal article (refereed), original research -
Increased macromolecular resonances in the rat cerebral cortex during severe energy failure as detected by 1H nuclear magnetic resonance spectroscopy
Hakumäki JM, Gröhn OHJ, Pirttilä T-RM, Kauppinen RA. 1996. Neuroscience letters. 212: 151-154 A1 Journal article (refereed), original research