Olli Gröhn

ComBating inter‐site differences in field strength: harmonizing preclinical traumatic brain injury MRI data

Quach, Mara; Ali, Idrish; Shultz, Sandy R; Casillas‐Espinosa, Pablo M; Hudson, Matthew R; Jones, Nigel C; Silva, Juliana C; Yamakawa, Glenn R; Braine, Emma L; Immonen, Riikka; Staba, Richard J; Tohka, Jussi; Harris, Neil G; Gröhn, Olli; O'Brien, Terence J; Wright, David K. 2024. Nmr in biomedicine. 37: A1 Journal article (refereed), original research

Modeling the stress and forces on multi-channel TMS coil arrays in high-field MRI scanners

Koponen, Maria A; Korhonen, Juuso T; Membrilla, Jose A Vilchez; Sinisalo, Heikki; Paasonen, Jaakko; Sanchez, Clemente Cobos; Gröhn, Olli; Ilmoniemi, Risto J; Souza, Victor H. 2024. Physics in medicine and biology. 69: A1 Journal article (refereed), original research

Resting-state functional MRI of the nose as a novel investigational window into the nervous system

Ponticorvo, Sara; Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A.; Tanila, Heikki; Filip, Pavel; Rothman, Douglas L.; Eberly, Lynn E.; Garwood, Michael; Metzger, Gregory J.; Gröhn, Olli; Michaeli, Shalom; Mangia, Silvia. 2024. Scientific reports. 14: . 26352 A1 Journal article (refereed), original research

A consensus protocol for functional connectivity analysis in the rat brain

Grandjean, Joanes; Desrosiers-Gregoire, Gabriel; Anckaerts, Cynthia; Angeles-Valdez, Diego; Ayad, Fadi; Barrière, David A.; Blockx, Ines; Bortel, Aleksandra; Broadwater, Margaret; Cardoso, Beatriz M.; Célestine, Marina; Chavez-Negrete, Jorge E.; Choi, Sangcheon; Christiaen, Emma; Clavijo, Perrin; Colon-Perez, Luis; Cramer, Samuel; Daniele, Tolomeo; Dempsey, Elaine; Diao, Yujian; Doelemeyer, Arno; Dopfel, David; Dvořáková, Lenka; Falfán-Melgoza, Claudia; Fernandes, Francisca F.; Fowler, Caitlin F. 2023. Nature neuroscience. 26: 673-681 A1 Journal article (refereed), original research

Axon fiber orientation as the source of T1 relaxation anisotropy in white matter: A study on corpus callosum in vivo and ex vivo

Kauppinen, Risto A; Thothard, Jeromy; Leskinen, Henri PP; Pisharady, Pramod K; Manninen, Eppu; Kettunen, Mikko; Lenglet, Christophe; Gröhn, Olli HJ; Garwood, Michael; Nissi, Mikko J. 2023. Magnetic resonance in medicine. 90: 708-721 A1 Journal article (refereed), original research

Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury

Chary, Karthik; Manninen, Eppu; Claessens, Jade; Ramirez-Manzanares, Alonso; Gröhn, Olli; Sierra, Alejandra. 2023. Scientific reports. 13: . 2219 A1 Journal article (refereed), original research

Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1

Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla. 2023. Epilepsia. 2024; 65: 511-526 A1 Journal article (refereed), original research

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S. 2023. Epilepsy research. 195: A1 Journal article (refereed), original research

Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala

Gureviciene, Irina; Laakso, Hanne; Narvaez, Omar; Paasonen, Ekaterina; Lehto, Lauri; Gurevicius, Kestutis; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli; Sierra, Alejandra; Tanila, Heikki. 2023. Frontiers in neuroscience. 17: . 1147547 A1 Journal article (refereed), original research

Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies

Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla. 2023. Epilepsy research. 2024; 199: A1 Journal article (refereed), original research

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

van Vliet, Erwin A.; Immonen, Riikka; Prager, Ofer; Friedman, Alon; Bankstahl, Jens P.; Wright, David K.; O'Brien, Terence J.; Potschka, Heidrun; Gröhn, Olli; Harris, Neil G.. 2022. Epilepsia open. [First published: 13 August 2022]: 1-47 A1 Journal article (refereed), original research

Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury

Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research

Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka. 2022. Brain research. 1788: A1 Journal article (refereed), original research

Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury

De Feo, Riccardo; Hämäläinen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Frontiers in neurology. 13: . 820267 A1 Journal article (refereed), original research

Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat

Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli. 2022. Magnetic resonance in medicine. 87: 2872-2884 A1 Journal article (refereed), original research

Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model

De Feo, Riccardo; Manninen, Eppu; Chary, Karthik; Hämäläinen, Elina; Immonen, Riikka; Andrade, Pedro; Ndode‐Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Epilepsia. 63: 1849-1861 A1 Journal article (refereed), original research

Histopathological modeling of status epilepticus-induced brain damage based on in vivo diffusion tensor imaging in rats

San Martín Molina, Isabel; Salo, Raimo A.; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2022. Frontiers in neuroscience. 16: . 944432 A1 Journal article (refereed), original research

MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains

Ndode-Ekane, Xavier Ekolle; Immonen, Riikka; Hämäläinen, Elina; Manninen, Eppu; Andrade, Pedro; Ciszek, Robert; Paananen, Tomi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research

Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition

Wu, Lin; Canna, Antonietta; Narvaez, Omar; Ma, Jun; Sang, Sheng; Lehto, Lauri J.; Sierra, Alejandra; Tanila, Heikki; Zhang, Yuan; Gröhn, Olli; Low, Walter C.; Filip, Pavel; Mangia, Silvia; Michaeli, Shalom. 2022. Scientific reports. 12: . 8565 A1 Journal article (refereed), original research

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research

Relaxation anisotropy of quantitative MRI parameters in biological tissues

Hänninen, Nina Elina; Liimatainen, Timo; Hanni, Matti; Gröhn, Olli; Nieminen, Miika Tapio; Nissi, Mikko Johannes. 2022. Scientific reports. 12: . 12155 A1 Journal article (refereed), original research

Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents

Sirmpilatze, Nikoloz; Mylius, Judith; Ortiz-Rios, Michael; Baudewig, Jürgen; Paasonen, Jaakko; Golkowski, Daniel; Ranft, Andreas; Ilg, Rüdiger; Gröhn, Olli; Boretius, Susann. 2022. eLife. 11: . e74813 A1 Journal article (refereed), original research

State Estimation of Time-Varying MRI with Radial Golden Angle Sampling

Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko. 2022. Journal of mathematical imaging and vision. 64: 825-844 A1 Journal article (refereed), original research

Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI

Paasonen, Jaakko; Stenroos, Petteri; Laakso, Hanne; Pirttimäki, Tiina; Paasonen, Ekaterina; Salo, Raimo A.; Tanila, Heikki; Idiyatullin, Djaudat; Garwood, Michael; Michaeli, Shalom; Mangia, Silvia; Gröhn, Olli. 2022. Neuroimage. 250: A1 Journal article (refereed), original research

Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis

Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Epilepsia. 62: 1852-1864 A1 Journal article (refereed), original research

Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases

De Feo, Riccardo; Shatillo, Artem; Sierra, Alejandra; Valverde, Juan Miguel; Gröhn, Olli; Giove, Federico; Tohka, Jussi. 2021. Neuroimage. 229: 117734 A1 Journal article (refereed), original research

Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats

Dvoráková, Lenka; Stenroos, Petteri; Paasonen, Ekaterina; Salo, Raimo A.; Paasonen, Jaakko; Gröhn, Olli. 2021. Nmr in biomedicine. 2022; 35: A1 Journal article (refereed), original research

Metabolism of hyperpolarised [1-13C]pyruvate in awake and anaesthetised rat brains

Hyppönen, Viivi; Stenroos, Petteri; Nivajärvi, Riikka; Ardenkjaer-Larsen, Jan Henrik; Gröhn, Olli; Paasonen, Jaakko; Kettunen, Mikko I. 2021. Nmr in biomedicine. 2022; 35: e4635 A1 Journal article (refereed), original research

Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury

Chary Karthik, Narvaez Omar, Salo Raimo A, San Martín Molina Isabel, Tohka Jussi, Aggarwal Manisha, Gröhn Olli, Sierra Alejandra. 2021. Frontiers in neuroscience. 15: 746214 A1 Journal article (refereed), original research

Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury

Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Brain structure and function. 2022; 227: 145-158 A1 Journal article (refereed), original research

RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats

Holikova, Klara; Laakso, Hanne; Salo, Raimo; Shatillo, Artem; Nurmi, Antti; Bares, Martin; Vanicek, Jiri; Michaeli, Shalom; Mangia, Silvia; Sierra, Alejandra; Gröhn, Olli. 2021. Frontiers in neuroscience. 15: 625167 A1 Journal article (refereed), original research

Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification

Genicio, Nuria; Bañobre-López, Manuel; Gröhn, Olli; Gallo, Juan. 2021. Coordination chemistry reviews. 447: 214150 A2 Review article, Literature review, Systematic review

Relaxation Anisotropy in Biological Tissues

Hänninen N; Nissi MJ; Hanni M; Gröhn OHJ; Nieminen MT; Liimatainen T. 2021.

Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats

Laakso, Hanne; Lehto, Lauri J; Paasonen, Jaakko; Salo, Raimo; Canna, Antonietta; Lavrov, Igor; Michaeli, Shalom; Gröhn, Olli; Mangia, Silvia. 2021. Magnetic resonance in medicine. 86: 2137-2145 A1 Journal article (refereed), original research

Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation

Miocchi, Paolo; Sierra, Alejandra; Maugeri, Laura; Stefanutti, Eleonora; Abdollahzadeh, Ali; Mangini, Fabio; Moraschi, Marta; Bukreeva, Inna; Massimi, Lorenzo; Brun, Francesco; Tohka, Jussi; Gröhn, Olli; Mittone, Alberto; Bravin, Alberto; Nicaise, Charles; Giove, Federico; Cedola, Alessia; Fratini, Michela. 2021. Physica medica. 81: 197-209 A1 Journal article (refereed), original research

A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis

Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W. Teoksessa: -(toim.) , 2020. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). s. 1013-1017. IEEE A4 Conference proceedings

Assessment of the structural complexity of diffusion MRI voxels using 3D electron microscopy in the rat brain

Salo, Raimo A; Belevich, Ilya; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2020. Neuroimage. 225: 117529 A1 Journal article (refereed), original research

Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate

Nivajärvi, R; Olsson, V; Hyppönen, V; Bowen, S; Leinonen, HM; Lesch, HP; Ardenkjaer-Larsen, JH; Gröhn, OHJ; Ylä-Herttuala, S; Kettunen, MI. 2020. Nmr in biomedicine. 33: e4250 A1 Journal article (refereed), original research

Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury

Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Journal of neurotrauma. 37: 2580-2594 A1 Journal article (refereed), original research

In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats

San Martín Molina, Isabel; Salo, Raimo A; Abdollahzadeh, Ali; Tohka, Jussi; Gröhn, Olli; Sierra, Alejandra. 2020. eNeuro. 7: ENEURO.0476-19.2020 A1 Journal article (refereed), original research

Individual head models for estimating the TMS-induced electric field in rat brain

Koponen, Lari M; Stenroos, Matti; Nieminen, Jaakko O; Jokivarsi, Kimmo; Gröhn, Olli; Ilmoniemi, Risto J. 2020. Scientific reports. 10: 17397 A1 Journal article (refereed), original research

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Neurobiology of disease. 145: 1-20 A1 Journal article (refereed), original research

Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat

Paasonen, J; Laakso, H; Pirttimäki, T; Stenroos, P; Salo, RA; Zhurakovskaya, E; Lehto, LJ; Tanila, H; Garwood, M; Michaeli, S; Idiyatullin, D; Mangia, S; Gröhn, O. 2020. Neuroimage. 206: 116338 A1 Journal article (refereed), original research

Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective

Fratini, Michela; Abdollahzadeh, Ali; DiNuzzo, Mauro; Salo, Raimo; Maugeri, Laura; Cedola, Alessia; Giove, Federico; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2020. Frontiers in neuroscience. 14: 72 A2 Review article, Literature review, Systematic review

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Neuroimage. 213: 116750 A1 Journal article (refereed), original research

RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation

Valverde, Juan Miguel; Shatillo, Artem; De Feo, Riccardo; Gröhn, Olli; Sierra, Alejandra; Tohka, Jussi. 2020. Frontiers in neuroscience. 14: 610239 A1 Journal article (refereed), original research

Temporal Huber Regularization for DCE-MRI

Hanhela, Matti; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko; Kolehmainen, Ville. 2020. Journal of mathematical imaging and vision. 62: 1334-1346 A1 Journal article (refereed), original research

Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks

Valverde, JM; Shatillo, A; De Feo, R; Gröhn, O; Sierra, A; Tohka, J. Teoksessa: Suk, HI; Liu, M; Yan, P; Lian, C(toim.) , 2019. Machine Learning in Medical Imaging. MLMI 2019. s. 195-202. Springer A3 Book section, Chapters in research books

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain

Knight, MJ; Damion, RA; McGarry, BL; Bosnell, R; Jokivarsi, KT; Gröhn, OHJ; Jezzard, P; Harston, GWJ; Carone, D; Kennedy, J; El-Tawil, S; Elliot, J; Muir, KW; Clatworthy, P; Kauppinen, RA. 2019. Biomedical spectroscopy and imaging. 8: 11-28 A1 Journal article (refereed), original research

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research. 150: 46-57 A1 Journal article (refereed), original research

Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease

Zhurakovskaya, E; Ishchenko, I; Gureviciene, I; Aliev, R; Gröhn, O; Tanila, H. 2019. Scientific reports. 9: 5380 A1 Journal article (refereed), original research

Lateral fluid-percussion injury leads to pituitary atrophy in rats

Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports. 9: 11819 A1 Journal article (refereed), original research

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. Frontiers in neuroscience. 13: 863 A1 Journal article (refereed), original research

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Neuropharmacology. 149: 113-123 A1 Journal article (refereed), original research

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. eNeuro. 6: 1-12 A1 Journal article (refereed), original research

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Vespa, PM; Shrestha, V; Abend, N; Agoston, D; Au, A; Bell, MJ; Bleck, TP; Blanco, MB; Claassen, J; Diaz-Arrastia, R; Duncan, D; Ellingson, B; Foreman, B; Gilmore, EJ; Hirsch, L; Hunn, M; Kamnaksh, A; McArthur, D; Morokoff, A; O'Brien, T; et al. (incl. Gröhn, Olli). 2019. Neurobiology of disease. 123: 110-114 A2 Review article, Literature review, Systematic review

Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit

Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Frontiers in neuroscience. 12: 548 A1 Journal article (refereed), original research

Clinical deep brain stimulation strategies for orientation-selective pathway activation

Slopsema, Julia P; Peña, Edgar; Patriat, Remi; Lehto, Lauri J; Gröhn, Olli; Mangia, Silvia; Harel, Noam; Michaeli, Shalom; Johnson, Matthew D. 2018. Journal of neural engineering. 15: 56029 A1 Journal article (refereed), original research

Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury

Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Journal of neurotrauma. 35: 2708-2717 A1 Journal article (refereed), original research

Dynamic MRI reconstruction from undersampled data with an anatomical prescan

Rasch, Julian; Kolehmainen, Ville; Nivajärvi, Riikka; Kettunen, Mikko; Grohn, Olli; Burger, Martin; Brinkmann, Eva-Maria. 2018. Inverse problems. 34: 74001 A1 Journal article (refereed), original research

Functional connectivity under six anesthesia protocols and the awake condition in rat brain

Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A; Kiviniemi, Vesa; Gröhn Olli. 2018. Neuroimage. 172: 9-20 A1 Journal article (refereed), original research

Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers

Immonen, Riikka; Harris, Neil G; Wright, David; Johnston, Leigh; Manninen, Eppu; Smith, Gregory; Paydar, Afshin; Branch, Craig; Grohn Olli. 2018. Neurobiology of disease. 2019; 123: 75-85 A2 Review article, Literature review, Systematic review

Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain

Salo, Raimo A; Belevich, Ilya; Manninen, Eppu; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2018. Neuroimage. 172: 404-414 A1 Journal article (refereed), original research

Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging

Shatillo, A; Lipponen, A; Salo, RA; Tanila, H; Verkhratsky, A; Giniatullin, R; Gröhn, OH. 2018. Journal of cerebral blood flow and metabolism. 2019; 39: 1949-1960 A1 Journal article (refereed), original research

State estimation in dynamic MRI

Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Huttunen, Joanna; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko. Teoksessa: -(toim.) , 2018. 2018 IEEE Nuclear Science Symposium and Medical Imaging (NSS/MIC): Conference Proceedings. s. 1-6. IEEE A4 Conference proceedings

Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex

Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Frontiers in neuroscience. 12: 899 A1 Journal article (refereed), original research

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

McGarry BL, Jokivarsi KT, Knight MJ, Grohn OHJ, Kauppinen RA. 2017. Journal of visualized experiments. 127: 1-6 A1 Journal article (refereed), original research

Conceptual Design of Flex-DBS, a Mechanically Reconfigurable Deep Brain Stimulation Probe

Johnson G, Lehto L, Mangia S, Gröhn O, Michaeli S, Kodandaramaiah S. Teoksessa: -(toim.) , 2017. Proceedings of the 2017 Design of Medical Devices Conference. s. V001T02A001. American Society of Mechanical Engineers A4 Conference proceedings

Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis

Salo RA, Miettinen T, Laitinen T, Gröhn O, Sierra A. 2017. Neuroimage. 152: 221-236 A1 Journal article (refereed), original research

Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat

Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Neuropharmacology. 119: 15-25 A1 Journal article (refereed), original research

In Vivo Imaging in Rodents

Gröhn O, Deleye S, Bertoglio D, Dedeurwaerdere S. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL(toim.) , 2017. Models of Seizures and Epilepsy (Second Edition). s. 197-215. Elsevier A3 Book section, Chapters in research books

Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame

Lehto Lauri J, Albors Aloma A. Sierra Alejandra, Tolppanen Laura, Eberly Lynn E, Mangia Silvia, Nurmi Antti, Michaeli Shalom, Gröhn Olli. 2017. Frontiers in neuroscience. 11: 433 A1 Journal article (refereed), original research

MB-SWIFT functional MRI during deep brain stimulation in rats

Lehto Lauri J, Idiyatullin Djaudat, Zhang Jinjin, Utecht Lynn, Adriany Gregor, Garwood Michael, Gröhn Olli, Michaeli Shalom, Mangia Silvia. 2017. Neuroimage. 159: 443-448 A1 Journal article (refereed), original research

Magnetization transfer SWIFT MRI consistently detects histologically verified myelin loss in the thalamocortical pathway after a traumatic brain injury in rat

Lehto LJ, Sierra A, Gröhn O. 2017. Nmr in biomedicine. 30: e3678 A1 Journal article (refereed), original research

Neuroimaging in animal models of epilepsy

Bertoglio Daniele, Verhaeghe Jeroen, Dedeurwaerdere Stefanie, Gröhn Olli. 2017. Neuroscience. 358: 277-299 A1 Journal article (refereed), original research

Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM)

Aggarwal M, Li X, Gröhn O, Sierra A. 2017. Journal of magnetic resonance imaging. 2018; 47: 554-564 A1 Journal article (refereed), original research

Orientation selective deep brain stimulation

Lehto Lauri J, Slopsema Julia P, Johnson Matthew D, Shatillo Artem, Teplitzky Benjamin A, Utecht Lynn, Adriany Gregor, Mangia Silvia, Sierra Alejandra, Low Walter C, Gröhn Olli, Michaeli Shalom. 2017. Journal of neural engineering. 14: 16016 A1 Journal article (refereed), original research

Searching for epilepsy's crystal ball

Gröhn Olli, Sierra Alejandra. 2017. eLife. 6: e29853 A1 Journal article (refereed), original research

State Estimation with Structural Priors in fMRI

Wettenhovi Ville-Veikko, Kolehmainen Ville, Huttunen Joanna, Kettunen Mikko, Gröhn Olli, Vauhkonen Marko. 2017. Journal of mathematical imaging and vision. 2018; 60: 174-188 A1 Journal article (refereed), original research

Stroke onset time determination using MRI relaxation times without non-ischaemic reference in a rat stroke model

Norton Terence JT, Pereyra Marcelo, Knight Michael J, McGarry Bryony M, Jokivarsi Kimmo T, Grohn Olli HJ, Kauppinen Risto A. 2017. Biomedical spectroscopy and imaging. 6: 25-35 A1 Journal article (refereed), original research

A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: application and validation in a rat acute stroke model

Knight MJ, Mcgarry BL, Rogers HJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Journal of cerebral blood flow and metabolism. 36: 1232-1243 A1 Journal article (refereed), original research

Advances in the development of biomarkers for epilepsy

Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. The Lancet Neurology. 15: 843-856 A2 Review article, Literature review, Systematic review

Common data elements and data management: Remedy to cure underpowered preclinical studies

Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Epilepsy research. 129: 87-90 A1 Journal article (refereed), original research

Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat

Paasonen Jaakko, Salo Raimo A, Shatillo Artem, Forsberg Markus M, Närväinen Johanna, Huttunen Joanna K, Gröhn Olli. 2016. European neuropsychopharmacology. 26: 518-531 A1 Journal article (refereed), original research

Determining stroke onset time using quantitative MRI: High accuracy, sensitivity and specificity obtained from magnetic resonance relaxation times

McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Cerebrovascular diseases extra. 6: 60-65 A1 Journal article (refereed), original research

Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage

Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. 2016. Osteoarthritis and cartilage. 24: 1656-1664 A1 Journal article (refereed), original research

Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI

Zhurakovskaya Ekaterina, Paasonen Jaakko, Shatillo Artem, Lipponen Arto, Salo Raimo, Aliev Raimo, Tanila Heikki, Gröhn Olli. 2016. PLoS ONE. 11: e0155343 A1 Journal article (refereed), original research

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents

Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 A1 Journal article (refereed), original research

Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia

Vieites-Prado Alba, Iglesias-Rey Ramón, Fernández-Susavila Héctor, da Silva-Candal Andrés, Rodríguez-Castro Emilio, Gröhn Olli HJ, Wellmann Sven, Sobrino Tomás, Castillo José, Campos Francisco. 2016. Stroke. 47: 2386-2396 A1 Journal article (refereed), original research

Resting-state functional MRI as a tool for evaluating brain hemodynamic responsiveness to external stimuli in rats

Paasonen Jaakko, Salo Raimo A, Huttunen Joanna K, Gröhn Olli. 2016. Magnetic resonance in medicine. 78: 1136-1146 A1 Journal article (refereed), original research

Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia

McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Sierra A, Gröhn OHJ, Kauppinen RA. 2016. International journal of stroke. 11: 677-82 A1 Journal article (refereed), original research

Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo

Nissinen Tuomo, Näkki Simo, Laakso Hanne, Kuciauskas Dalius, Kaupinis Algirdas, Kettunen Mikko I, Liimatainen Timo, Hyvönen Mervi, Valius Mindaugas, Gröhn Olli, Lehto Vesa-Pekka. 2016. Acs applied materials and interfaces. 8: 32723-32731 A1 Journal article (refereed), original research

Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in AßPP/PS1 mice both in vivo and ex vivo

Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki. 2015. Journal of Alzheimer's disease. 46: 926-946 A1 Journal article (refereed), original research

Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat

Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Frontiers in neuroscience. 9: 12 p A1 Journal article (refereed), original research

Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model

Heidi Marjonen, Alejandra Sierra, Anna Nyman, Vladimir Rogojin, Olli Gröhn, Anni-Maija Linden, Sampsa Hautaniemi, Nina Kaminen-Ahola. 2015. PLoS ONE. 10: e0124931 A1 Journal article (refereed), original research

Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis

Sierra A, Gröhn O, Pitkänen A. 2015. Neuroscience. 309: 162-172 A2 Review article, Literature review, Systematic review

Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI

Shatillo Artem, Salo Raimo A, Giniatullin Rashid, Gröhn Olli H. 2015. Neuropharmacology. 93: 164-170 A1 Journal article (refereed), original research

Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats

Levijoki Jouko, Kivikko Matti, Pollesello Piero, Sallinen Jukka, Hyttilä-Hopponen Minja, Kuoppamäki Mikko, Haasio Kristiina, Gröhn Olli, Miettinen Riitta, Puoliväli Jukka, Tähtivaara Leena, Yrjänheikki Juha, Haapalinna Antti. 2015. European journal of pharmacology. 750: 132-140 A1 Journal article (refereed), original research

MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain

Hakkarainen Hanne, Sierra Alejandra, Mangia Silvia, Garwood Michael, Michaeli Shalom, Gröhn Olli, Liimatainen Timo. 2015. Magnetic resonance in medicine. first published online: 3 FEB 2015: 8 p A1 Journal article (refereed), original research

Phase imaging in brain using SWIFT

Lehto Lauri Juhani, Garwood Michael, Grohn Olli, Corum Curtis Andrew. 2015. Journal of magnetic resonance. 252: 20-28 A1 Journal article (refereed), original research

Decreased resting functional connectivity after traumatic brain injury in the rat

Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. PLoS ONE. 2014 Apr 18;9(4): e95280 A1 Journal article (refereed), original research

Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats

Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Epilepsy research. 2014 May;108(4): 653-65 A1 Journal article (refereed), original research

Facile synthesis of biocompatible superparamagnetic mesoporous nanoparticles for imageable drug delivery

Nissinen Tuomo, Näkki Simo, Latikka Mika, Heinonen Markku, Liimatainen Timo, Xu Wujun, Ras Robin HA, Gröhn Olli, Riikonen Joakim, Lehto Vesa-Pekka. 2014. Microporous and mesoporous materials. 195: 2-8 A1 Journal article (refereed), original research

Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging

Teplov Victor, Shatillo Artem, Nippolainen Ervin, Gröhn Olli, Giniatullin Rashid, Kamshilin Alexei A. 2014. Journal of biomedical optics. 19: 046011-1-9 A1 Journal article (refereed), original research

Measurement of T1 relaxation time of osteochondral specimens using VFA-SWIFT

Nissi Mikko J, Lehto Lauri J, Corum Curtis A, Idiyatullin Djaudat, Ellermann Jutta M, Gröhn Olli HJ, Nieminen Miika T. 2014. Magnetic resonance in medicine. -: - A1 Journal article (refereed), original research

Opposite reactivity of meningeal versus cortical microvessels to the nitric oxide donor glyceryl trinitrate evaluated in vivo with two-photon imaging

Pryazhnikov E, Kislin M, Tibeykina M, Toptunov D, Ptukha A, Shatillo A, Gröhn O, Giniatullin R, Khiroug L. 2014. PLoS ONE. 2014 Feb 28;9(2):e89699: e89699 A1 Journal article (refereed), original research

Parenchymal spin-lock fMRI signals associated with cortical spreading depression

Autio JA, Shatillo A, Giniatullin R, Gröhn OH. 2014. Journal of cerebral blood flow and metabolism. 34: 768-775 A1 Journal article (refereed), original research

Posttraumatic epilepsy - Disease or comorbidity?

Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior. 2014 Feb 11.: -- A2 Review article, Literature review, Systematic review

Progressive volume loss and white matter degeneration in cstb-deficient mice: a diffusion tensor and longitudinal volumetry MRI study

Manninen O, Laitinen T, Lehtimäki KK, Tegelberg S, Lehesjoki AE, Gröhn O, Kopra O. 2014. PLoS ONE. 2014 Mar 6;9(3):e90709.: e90709 A1 Journal article (refereed), original research

Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities

Rogers Harriet J, McGarry Bryony L, Knight Michael J, Jokivarsi Kimmo T, Gröhn Olli H, Kauppinen Risto A. 2014. Neuroreport. 2014 Oct 22;25(15): 1180-1185 A1 Journal article (refereed), original research

Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities

Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S. 2014. American journal of physiology : heart and circulatory physiology. 307: H1226-H1232 A1 Journal article (refereed), original research

Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system

Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M, Gu C, Khazipov R, Davletov B, Grohn O, Giniatullin R. 2013. Neuroscience. 2013 Sep 11;253C: 341-349 A1 Journal article (refereed), original research

Diffusion tensor imaging of hippocampal network plasticity

Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Brain structure and function. 220: 781-801 A1 Journal article (refereed), original research

In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders

Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A. 2013. International journal of cancer. 6 DEC 2013: -- A1 Journal article (refereed), original research

MRI biomarkers for post-traumatic epileptogenesis.

Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. Journal of neurotrauma. 2013 Jul 15;30(14): 1305-9 A1 Journal article (refereed), original research

Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI

Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Journal of neurotrauma. : 546-56 A1 Journal article (refereed), original research

Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI) in Permanent Focal Cerebral Ischemia in Rat

Jokivarsi KT, Liimatainen T, Kauppinen RA, Gröhn OH, Närväinen J. 2013. PLoS ONE. 2013 Jul 17;8(7):e69157: -- A1 Journal article (refereed), original research

White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B-Deficient Mice

Manninen O, Koskenkorva P, Lehtimäki KK, Hyppönen J, Könönen M, Laitinen T, Kalimo H, Kopra O, Kälviäinen R, Gröhn O, Lehesjoki AE, Vanninen R. 2013. Radiology. : -- A1 Journal article (refereed), original research

Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT

Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Neuroimage. 2012 Jul 16;61(4): 761-72 A1 Journal article (refereed), original research

Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo

Musthafa HS, Dragneva G, Lottonen L, Merentie M, Petrov L, Heikura T, Ylä-Herttuala E, Ylä-Herttuala S, Gröhn O, Liimatainen T. 2012. Magnetic resonance in medicine. 2012 Jun 26: -- A1 Journal article (refereed), original research

Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses

Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Journal of nutrition health and aging. 16: 631-635 A1 Journal article (refereed), original research

Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions

Torvinen S, Silvennoinen M, Piitulainen H, Närväinen J, Tuunanen P, Gröhn O, Koch LG, Britton SL, Kainulainen H. 2012. PLoS ONE. 2012;7(11):e48345: -- A1 Journal article (refereed), original research

Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures

Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Epilepsia. 2012 Jul;53(7): 1245-53 A1 Journal article (refereed), original research

Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia

Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Journal of cerebral blood flow and metabolism. 31: 1119-1132 A1 Journal article (refereed), original research

Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat

Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Brain structure and function. 216: 123-135 A1 Journal article (refereed), original research

Evoked local field potentials can explain temporal variation in blood oxygenation level-dependent responses in rat somatosensory cortex

Huttunen Joanna K, Niskanen Juha-Pekka, Lehto Lauri J, Airaksinen Antti M, Niskanen Eini I, Penttonen Markku, Gröhn Olli. 2011. Nmr in biomedicine. 24: 209-215 A1 Journal article (refereed), original research

Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8(mnd) : implications to delayed myelination and oligodendrocyte maturation

Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O. 2011. Neuropathology and applied neurobiology. 2012 Aug;38(5): 471-86 A1 Journal article (refereed), original research

Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67: 269-277, 2012

Liimatainen T, Sierra A, Hanson T, Sorce DJ, Ylä-Herttuala S, Garwood M, Michaeli S, Gröhn O. 2011. Magnetic resonance in medicine. 2012 Jan;67(1): 269-277 A1 Journal article (refereed), original research

Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats

Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Journal of cerebral blood flow and metabolism. 31: 166-177 A1 Journal article (refereed), original research

Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Epilepsia. : 57-60 B1 Non-refereed journal articles

VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2

Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2011. Cancer gene therapy. 18: 100-9 A1 Journal article (refereed), original research

Association of chronic vascular changes with functional outcome after traumatic brain injury in rats

Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Journal of neurotrauma. 27: 2203-2219 A1 Journal article (refereed), original research

Cerebral blood volume alterations in the perilesional areas in the rat brain after traumatic brain injury¿comparison with behavioral outcome

Immonen R, Heikkinen T, Tähtivaara L, Nurmi A, Stenius TK, Puoliväli J, Tuinstra T, Phinney AL, Van Vliet B, Yrjänheikki J et al. 2010. Journal of cerebral blood flow and metabolism. 30: 1318 -1328 A1 Journal article (refereed), original research

Correlating tissue outcome with quantitative multiparametric MRI of acute cerebral ischemia in rats

Jokivarsi KT, Hiltunen Y, Tuunanen PI, Kauppinen RA & Gröhn OH. 2010. Journal of cerebral blood flow and metabolism. 30: 415-427 A1 Journal article (refereed), original research

Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice

Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. 2010. Cancer gene therapy. 18: 100-109 A1 Journal article (refereed), original research

Diffusion tensor MRI of axonal plasticity in the rat hippocampus

Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Neuroimage. 51: 251-530 A1 Journal article (refereed), original research

Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats

Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Neuroscience letters. 484: 39-42 A1 Journal article (refereed), original research

Estimation of the onset time of cerebral ischemia using T1rho and T2 MRI in rats

Jokivarsi KT, Hiltunen Y, Gröhn H, Tuunanen P, Gröhn OH & Kauppinen RA. 2010. Stroke. 41: 2335-2340 A1 Journal article (refereed), original research

NMR relaxation times of trabecular bone - reproducibility, relationships to tissue structure and effects of sample freezing

Prantner V, Isaksson H, Närväinen J, Lammentausta E, Nissi MJ, Avela J, Gröhn OH, Jurvelin JS. 2010. Physics in medicine and biology. 55(2010): 1-13 A1 Journal article (refereed), original research

Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence

Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Magnetic resonance in medicine. 64: 1191-1199 A1 Journal article (refereed), original research

Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy

Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Neuroscience. 166: 312-332 A1 Journal article (refereed), original research

(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery

Kaikkonen MU, Lesch HP, Pikkarainen J, Räty JK, Vuorio T, Huhtala T, Taavitsainen M, Laitinen T, Tuunanen P, Gröhn O, Närvänen A, Airenne KJ, Ylä-Herttuala S. 2009. Gene therapy. 16: 894-904 A1 Journal article (refereed), original research

Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up

Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Experimental neurology. 215: 29-40 A1 Journal article (refereed), original research

From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options

Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. EPILEPSIA. SUPPLEMENT. 50: 21-29 A2 Review article, Literature review, Systematic review

Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury

Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Neuroimage. 45: 1-9 A1 Journal article (refereed), original research

Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat

Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Experimental neurology. 217: 154-164 A1 Journal article (refereed), original research

Quantitative assessment of water pools by T1rho and T2rho MRI in acute cerebral ischemia of the rat

Jokivarsi KT, Niskanen J-P, Michaeli S, Gröhn HI, Garwood M, Kauppinen RA, Gröhn OH. 2009. Journal of cerebral blood flow and metabolism. 29: 206-216 A1 Journal article (refereed), original research

1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo

Liimatainen TJ, Erkkilä AT, Valonen P, Vidgren H, Lakso M, Wong G, Gröhn OHJ, Ylä-Herttuala S, Hakumäki JM. 2008. Magnetic resonance in medicine. 59: 1232-1238 A1 Journal article (refereed), original research

A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease

Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. Biochemical and biophysical research communications. 375: 356-361 A1 Journal article (refereed), original research

Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex

Huttunen JK, Gröhn O, Penttonen M. 2008. Neuroimage. 39: 775-785 A1 Journal article (refereed), original research

High-resolution ultrasound perfusion imaging of therapeutic angiogenesis

Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn OH, Ylä-Herttuala S. 2008. JACC : cardiovascular imaging. 1: 83 - 91 A1 Journal article (refereed), original research

Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat

Parry-Jones AR, Liimatainen T, Kauppinen RA, Gröhn OH, Rothwell NJ. 2008. Magnetic resonance in medicine. 59: 1239-1249 A1 Journal article (refereed), original research

Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus

Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Neuroimage. 40: 1718-1730 A1 Journal article (refereed), original research

T2, Carr-Purcell T2 and T1rho of fat and water as surrogate markers of trabecular bone structure

Lammentausta E, Silvast TS, Närväinen J, Jurvelin JS, Nieminen MT, Gröhn OHJ. 2008. Physics in medicine and biology. 53: 543-555 A1 Journal article (refereed), original research

Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs

Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Gröhn OH, Ylä-Herttuala S. 2008. Cardiovascular research. 80: 263-270 A1 Journal article (refereed), original research

Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho

Sierra A, Michaeli S, Niskanen J-P, Valonen PK, Gröhn HI, Ylä-Herttuala S, Garwood M, Gröhn OH. 2008. Magnetic resonance in medicine. 59: 1311-1319 A1 Journal article (refereed), original research

Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle

Kholová I, Koota S, Kaskenpää N, Leppänen P, Närväinen J, Kavec M, Rissanen TT, Hazes T, Korpisalo P, Gröhn O, Ylä-Herttuala S. 2007. Human gene therapy. 18: 232-244 A1 Journal article (refereed), original research

Epileptogenesis in experimental models

Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. EPILEPSIA. SUPPLEMENT. 48: 13-20 A1 Journal article (refereed), original research

Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma

Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OHJ. 2007. Radiology. 243: 796-803 A1 Journal article (refereed), original research

Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations

Gröhn O, Pitkänen A. 2007. EPILEPSIA. SUPPLEMENT. 48: 3-10 A1 Journal article (refereed), original research

Non-invasive imaging in gene therapy

Räty JK, Liimatainen T, Kaikkonen MU, Gröhn O, Airenne KJ, Ylä-Herttuala S. 2007. Molecular therapy. 15: 1579-1586 A2 Review article, Literature review, Systematic review

Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia

Jokivarsi KT, Gröhn HI, Gröhn OH, Kauppinen RA. 2007. Magnetic resonance in medicine. 57: 647-653 A1 Journal article (refereed), original research

Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis

Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Brain. 130: 3155-3168 A1 Journal article (refereed), original research

Spectroscopic imaging with volume selection by unpaired adiabatic pi pulses: Theory and application

Valette J, Park J-Y, Gröhn O, Ugurbil K, Garwood M, Henry P-G. 2007. Journal of magnetic resonance. 189: 1-12 A1 Journal article (refereed), original research

Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions

Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Neuroscience letters. 428: 99-102 A1 Journal article (refereed), original research

Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia

Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Free radical biology and medicine. 40: 1776-1784 A1 Journal article (refereed), original research

Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo

Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Neuroimage. 30: 130-135 A1 Journal article (refereed), original research

Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy

Liimatainen T, Hakumäki J, Tkác I, Gröhn O. 2006. Nmr in biomedicine. 19: 554-559 A1 Journal article (refereed), original research

Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis

Rissanen TT, Korpisalo P, Markkanen JE, Liimatainen T, Ordén M-R, Kholová I, de Goede A, Heikura T, Gröhn OH, Ylä-Herttuala S. 2005. Circulation. 112: 3937-3946 A1 Journal article (refereed), original research

Dispersion of cerebral on-resonance T1 in the rotating frame (T1 rho) in global ischaemia

Kettunen MI, Kauppinen RA, Gröhn OHJ. 2005. Applied magnetic resonance. 29: 89-106 A1 Journal article (refereed), original research

Dynamic dephasing changes in developing ischemic cerebral infarction in rats studied by Carr-Purcell T2 magnetic resonance imaging

Kavec M, Gröhn OHJ, Gröhn HI, Garwood M, Kauppinen RA. 2005. Magnetic resonance in medicine. 53: 960-964 A1 Journal article (refereed), original research

Exchange-influenced T2rho contrast in human brain images measured with adiabatic radio frequency pulses

Michaeli S, Gröhn H, Gröhn O, Sorce DJ, Kauppinen R, Springer CS Jr, Ugurbil K, Garwood M. 2005. Magnetic resonance in medicine. 53: 823-829 A1 Journal article (refereed), original research

Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain

Pitkänen A, Gröhn O. 2005. Epilepsy currents

High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma

Valonen PK, Griffin JL, Lehtimäki KK, Liimatainen T, Nicholson JK, Gröhn OHJ, Kauppinen RA. 2005. Nmr in biomedicine. 18: 252-259 A1 Journal article (refereed), original research

Quantitative T(1rho) and adiabatic Carr-Purcell T2 magnetic resonance imaging of human occipital lobe at 4 T

Gröhn HI, Michaeli S, Garwood M, Kauppinen RA, Gröhn OHJ. 2005. Magnetic resonance in medicine. 54: 14-19 A1 Journal article (refereed), original research

Tumour gene therapy monitoring using magnetic resonance imaging and spectroscopy

Kettunen MI, Gröhn OHJ. 2005. Current gene therapy. 5: 685-696 A1 Journal article (refereed), original research

Acute cerebral ischemia in rats studied by Carr-Purcell spin-echo magnetic resonance imaging: Assessment of blood oxygenation level-dependent and tissue effects on the transverse relaxation

Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Garwood M, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 1138-1146 A1 Journal article (refereed), original research

B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo

Mäkelä HI, De Vita E, Gröhn OHJ, Kettunen MI, Kavec M, Lythgoe M, Garwood M, Ordidge R, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 4-8 A1 Journal article (refereed), original research

In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent

Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, Adriany G, Gröhn OHJ, Grimm R, Poduslo JF. 2004. Magnetic resonance in medicine. 52: 1263-1271 A1 Journal article (refereed), original research

Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy

Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Epilepsia. 45: 1024-1034 A1 Journal article (refereed), original research

Quantitative T1rho NMR spectroscopy of rat cerebral metabolites in vivo: Effects of global ischemia

Kettunen MI, Gröhn OHJ, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 875-880 A1 Journal article (refereed), original research

Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density

Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Gröhn OHJ, Ylä-Herttuala S, Kauppinen RA. 2004. Journal of magnetic resonance imaging. 19: 389-396 A1 Journal article (refereed), original research

Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death

Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Cancer research. 63: 3195-3201 A1 Journal article (refereed), original research

Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*

Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. 2003. Journal of biological chemistry. 278: 45915-45923 A1 Journal article (refereed), original research

Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma

Gröhn OHJ, Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Ylä-Herttuala S, Kauppinen RA, Garwood M. 2003. Cancer research. 63: 7571-7574 A1 Journal article (refereed), original research

On- and off-resonance T1rho MRI in acute cerebral ischemia of the rat

Gröhn OHJ, Mäkelä HI, Lukkarinen JA, DelaBarre L, Lin J, Garwood M, Kauppinen RA. 2003. Magnetic resonance in medicine. 49: 172-176 A1 Journal article (refereed), original research

Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice

Kaasinen SK, Gröhn OHJ, Keinänen TA, Alhonen L, Jänne J. 2003. Experimental neurology. 183: 645-652 A1 Journal article (refereed), original research

Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained

Kuhmonen J, Lukkarinen J, Gröhn O, Jolkkonen J, Sivenius J. 2002. Journal of pharmacy and pharmacology. 54: 1565-1569 A1 Journal article (refereed), original research

Early gene therapy - induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame

Hakumäki JM, Gröhn OHJ, Tyynelä K, Valonen P, Ylä-Herttuala S, Kauppinen RA. 2002. Cancer gene therapy. 9: 338-345 A1 Journal article (refereed), original research

Effects of intracellular pH, blood, and tissue oxygen tension on T-1rho relaxation in rat brain

Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Magnetic resonance in medicine. 48: 470-477 A1 Journal article (refereed), original research

Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy

Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. Teoksessa: Sutula T, Pitkänen A(toim.) , 2002. Do Seizures Damage the Brain. s. 67-83. Elsevier A3 Book section, Chapters in research books

Quantitative T (1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat

Mäkelä HI, Kettunen MI, Gröhn OHJ, Kauppinen RA. 2002. Journal of cerebral blood flow and metabolism. 22: 547-558 A1 Journal article (refereed), original research

Quantitative assessment of the balance between oxygen delivery and consumption in the rat brain after transient ischemia with T2-BOLD magnetic resonance imaging

Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Journal of cerebral blood flow and metabolism. 22: 262-270 A1 Journal article (refereed), original research

Assessment of brain tissue viability in acute ischemic stroke by BOLD NMR

Gröhn OHJ, Kauppinen RA. 2001. Nmr in biomedicine. 14: 432-440 D1 Article in a trade journal

Cerebral T1rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization

Kettunen MI, Gröhn OHJ, Penttonen M, Kauppinen RA. 2001. Magnetic resonance in medicine. 46: 565-572 A1 Journal article (refereed), original research

Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions

Mäkelä HI, Gröhn OHJ, Kettunen MI, Kauppinen RA. 2001. Biochemical and biophysical research communications. 289: 813-818 A1 Journal article (refereed), original research

Use of spin echo T2 BOLD in assessment of cerebral misery perfusion at 1.5 T

Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2001. Magnetic resonance materials in physics biology and medicine. 12: 32-39 A1 Journal article (refereed), original research

Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho

Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 1457-1466 A1 Journal article (refereed), original research

Graded reduction of cerebral blood flow in rat as detected by the nuclear magnetic resonance relaxation time T2: a theoretical and experimental approach

Gröhn OHJ, Kettunen MI, Penttonen M, Oja JME, van Zijl PCM, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 316-326 A1 Journal article (refereed), original research

Interrelations of T1 and diffusion of water in acute cerebral ischemia of the rat

Kettunen MI, Gröhn OHJ, Lukkarinen JA, Vainio P, Silvennoinen MJ, Kauppinen RA. 2000. Magnetic resonance in medicine. 44: 833-839 A1 Journal article (refereed), original research

Magnetic Resonance Imaging of Acute Cerebral Ischaemia. Novel Haemodynamic and Parenchymal Indicators of Reversible and Irreversible Ischaemia

Gröhn O. 2000. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet G5 Doctoral dissertation (article)

Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia

Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Molecular and cellular neuroscience. 16: 87-96 A1 Journal article (refereed), original research

Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat

Lukkarinen JA, Gröhn OHJ, Alhonen LI, Jänne J, Kauppinen RA. 1999. Brain research. 826: 325-329 A1 Journal article (refereed), original research

Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame

Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Magnetic resonance in medicine. 42: 268-276 A1 Journal article (refereed), original research

Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging

Poptani H, Puumalainen A-M, Gröhn OH, Loimas S, Kainulainen R, Ylä-Herttuala S, Kauppinen RA. 1998. Cancer gene therapy. 5: 101-109 A1 Journal article (refereed), original research

Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats

Lukkarinen JA, Kauppinen RA, Gröhn OHJ, Oja JME, Sinervirta R, Järvinen A, Alhonen LI, Jänne J. 1998. European journal of neuroscience. 10: 2046-2055 A1 Journal article (refereed), original research

Noninvasive detection of cerebral hypoperfusion and reversible ischemia from reductions in the magnetic resonance imaging relaxation time, T2

Gröhn OHJ, Lukkarinen JA, Oja JME, van Zijl PCM, Ulatowski JA, Traystman RJ, Kauppinen RA. 1998. Journal of cerebral blood flow and metabolism. 18: 911-920 A1 Journal article (refereed), original research

Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion

Lukkarinen J, Gröhn OHJ, Sinervirta R, Järvinen A, Kauppinen RA, Jänne J, Alhonen LI. 1997. Stroke. 28: 639-645 A1 Journal article (refereed), original research

Increased macromolecular resonances in the rat cerebral cortex during severe energy failure as detected by 1H nuclear magnetic resonance spectroscopy

Hakumäki JM, Gröhn OHJ, Pirttilä T-RM, Kauppinen RA. 1996. Neuroscience letters. 212: 151-154 A1 Journal article (refereed), original research

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Research groups

Projects

ComBating inter‐site differences in field strength: harmonizing preclinical traumatic brain injury MRI data

Modeling the stress and forces on multi-channel TMS coil arrays in high-field MRI scanners

Resting-state functional MRI of the nose as a novel investigational window into the nervous system

A consensus protocol for functional connectivity analysis in the rat brain

Axon fiber orientation as the source of T1 relaxation anisotropy in white matter: A study on corpus callosum in vivo and ex vivo

Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury

Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala

Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury

Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury

Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat

Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model

Histopathological modeling of status epilepticus-induced brain damage based on in vivo diffusion tensor imaging in rats

MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains

Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Relaxation anisotropy of quantitative MRI parameters in biological tissues

Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents

State Estimation of Time-Varying MRI with Radial Golden Angle Sampling

Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI

Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis

Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases

Brain fMRI during orientation selective epidural spinal cord stimulation

Data-Driven Regularization Parameter Selection in Dynamic MRI

Infantile status epilepticus disrupts myelin development

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats

Metabolism of hyperpolarised [1-13C]pyruvate in awake and anaesthetised rat brains

Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury

Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury

RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats

Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification

Relaxation Anisotropy in Biological Tissues

Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats

Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation

A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis

Assessment of the structural complexity of diffusion MRI voxels using 3D electron microscopy in the rat brain

Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate

Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury

In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats

Individual head models for estimating the TMS-induced electric field in rat brain

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat

Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation

Temporal Huber Regularization for DCE-MRI

Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease

Lateral fluid-percussion injury leads to pituitary atrophy in rats

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit

Clinical deep brain stimulation strategies for orientation-selective pathway activation

Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury

Dynamic MRI reconstruction from undersampled data with an anatomical prescan

Functional connectivity under six anesthesia protocols and the awake condition in rat brain

Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers

Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain

Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging

State estimation in dynamic MRI

Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Conceptual Design of Flex-DBS, a Mechanically Reconfigurable Deep Brain Stimulation Probe

Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis

Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat

In Vivo Imaging in Rodents

Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame