Aaro Jalkanen

A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery

Järvinen, Juulia; Adla, Santosh Kumar; Tampio, Janne; Jalkanen, Aaro; Sloan, Kenneth B; Huttunen, Kristiina M; Rautio, Jarkko, 2026, Chemmedchem, 21, 2, e202500856. A1 Journal article (refereed), original research

Altered Retinal Dopamine Homeostasis in Murine Models of Retinitis Pigmentosa

Vainionpää, Katri; Lappalainen, Eerik; Nilsson, Anna; Pavela, Ida; Torsti, Tommi; Seemab, Umair; Mäkinen, Elina; Shariatgorji, Reza; Andrén, Per E; Jalkanen, Aaro; Forsberg, Markus M; Leinonen, Henri, 2026, Journal of neurochemistry, 170, 9, e70552. A1 Journal article (refereed), original research

Sodium-Dependent Multivitamin Transporter Facilitates Brain and Neuronal Uptake of a Creatine Analogue

Králová, Adéla; Kuorikoski, Ville; Anamea, Landry; Tampio, Janne; Tonduru, Arun Kumar; Cui, Hengjing; Leinonen, Henri; Rysä, Jaana; Poso, Antti; Terasaki, Tetsuya; Jalkanen, Aaro; Kronenberger, Thales; Huttunen, Kristiina M., 2026, Acs chemical neuroscience, [Epub ahead of print 17 Sep 2026], 1-17. A1 Journal article (refereed), original research

A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation

Králová, Adéla; Montaser, Ahmed B; Tampio, Janne; Adla, Santosh Kumar; Jalkanen, Aaro; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmacology, 995, 177409. A1 Journal article (refereed), original research

Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas

Tampio, Janne; Králová, Adéla; Riihioja, Sara; Pitkänen, Sofia; Markowicz-Piasecka, Magdalena; Ihamäki, Olli; Savolainen, Katja; Torunoglu, Sema T; Jalkanen, Aaro J; Lehtonen, Marko; Kauppinen, Anu; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmaceutics and biopharmaceutics, 214, 114797. A1 Journal article (refereed), original research

Brain-targeted Jedi1 and Jedi2 derivatives as potent enhancers of Piezo1 ion channel activity

Anamea, Landry; Králová, Adéla; Tampio, Janne; Shakirzyanova, Anastasia; Hänninen, Milka; Giniatullin, Rashid; Jalkanen, Aaro J; Malm, Tarja; Huttunen, Kristiina M, 2025, European journal of medicinal chemistry, 302, Part 2, 118359. A1 Journal article (refereed), original research

Progressive rod bipolar cell loss, ubiquitin accumulation, and subretinal drusenoid deposits in Cln3Δex7/8 mice: New insights into juvenile neuronal ceroid lipofuscinosis pathogenesis

Torsti, Tommi; Tamminen, Toni; Toropainen, Elisa; Jalkanen, Aaro; Kauppinen, Anu; Kaarniranta, Kai; Forsberg, Markus M, 2025, Experimental eye research, 263, 110766. A1 Journal article (refereed), original research

Estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise

Lee, Earric; Nissinen, Tuuli A.; Ylä-Outinen, Laura; Jalkanen, Aaro; Karppinen, Jari E; Vieira-Potter, Victoria Jeanne; Lipponen, Arto; Karvinen, Sira, 2024, Frontiers in neuroscience, 18, 1399229. A1 Journal article (refereed), original research

The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2024, European journal of pharmaceutical sciences, 203, 106937. A1 Journal article (refereed), original research

Altering distribution profile of palbociclib by its prodrugs

Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko, 2023, European journal of pharmaceutical sciences, 192, 106637. A1 Journal article (refereed), original research

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon

Cui, Hengjing; Elford, Joshua D; Alitalo, Okko; Perez-Pardo, Paula; Tampio, Janne; Huttunen, Kristiina M; Kraneveld, Aletta; Forsberg, Markus M; Myöhänen, Timo T; Jalkanen, Aaro J, 2023, Neurobiology of aging, 129, 62-71. A1 Journal article (refereed), original research

Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

Tonduru, Arun Kumar; Maljaei, Seyed Hamed; Adla, Santosh Kumar; Anamea, Landry; Tampio, Janne; Králová, Adéla; Jalkanen, Aaro J; Espada, Catarina; Santos, Inês Falcato; Montaser, Ahmed B; Rautio, Jarkko; Kronenberger, Thales; Poso, Antti; Huttunen, Kristiina M, 2023, Journal of medicinal chemistry, 66, 22, 15094-15114. A1 Journal article (refereed), original research

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Toppila, Maija; Hytti, Maria; Korhonen, Eveliina; Ranta-aho, Sofia; Harju, Niina; Forsberg, Markus M.; Kaarniranta, Kai; Jalkanen, Aaro; Kauppinen, Anu, 2023, Antioxidants, 12, 6, 1279. A1 Journal article (refereed), original research

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M, 2022, Life sciences, 310, 121088. A1 Journal article (refereed), original research

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko, 2022, Brain disorders, 6, 100035. A1 Journal article (refereed), original research

Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity

Grotell, Milo; den Hollander, Bjørnar; Jalkanen, Aaro; Törrönen, Essi; Ihalainen, Jouni; de Miguel, Elena; Dudek, Mateusz; Kettunen, Mikko I; Hyytiä, Petri; Forsberg, Markus M; Kankuri, Esko; Korpi, Esa R, 2021, Frontiers in pharmacology, 12, 679579. A1 Journal article (refereed), original research

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

Jalkanen, Aaro J.; Ihalainen, Jouni; Lehtonen, Marko; Forsberg, Markus M.; Rautio, Jarkko; Huttunen, Kristiina M.; Gynther, Mikko, 2021, International journal of pharmaceutics, 596, 120300. A1 Journal article (refereed), original research

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Efflux Transporter Inhibitors Can Improve the Brain Uptake and Apoptosis-Inducing Effects of Vinblastine in Cancer Cells

Montaser, Ahmed; Markowicz-Piasecka, Magdalena; Sikora, Joanna; Jalkanen, Aaro; Huttunen, Kristiina M, 2020, International journal of pharmaceutics, 586, 119585. A1 Journal article (refereed), original research

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M, 2020, Acs chemical neuroscience, 11, 24, 4301-4315. A1 Journal article (refereed), original research

Ravitsemusongelmille altistavat lääkkeet iäkkäillä

Solonen, Sanni; Jalkanen, Henna; Jalkanen, Aaro, 2020, Dosis, 36, 1, 60-74. A2 Review article, Literature review, Systematic review

Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone

Jalkanen, Aaro; Lassheikki, Veera; Torsti, Tommi; Gharib, Elham; Lehtonen, Marko; Juvonen, Risto O, 2020, Xenobiotica, 2021; 51, 3, 268-278. A1 Journal article (refereed), original research

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J, 2019, eNeuro, 6, 1, 1-12. A1 Journal article (refereed), original research

Extracellular Prolyl Oligopeptidase Derived from Activated Microglia is a Potential Neuroprotection Target.

Natunen, Teemu A; Gynther, Mikko; Rostalski, Hannah; Jaako, Külli; Jalkanen, Aaro J, 2018, Basic and clinical pharmacology and toxicology, 2019; 124, 1, 40-49. A1 Journal article (refereed), original research

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats

Savolainen, Katja; Ihalainen, Jouni; Jalkanen, Aaaro J; Forsberg, Markus M, 2018, Psychopharmacology, 2019; 236, 4, 1245-1253. A1 Journal article (refereed), original research

Brief isoflurane anesthesia regulates striatal AKT-GSK3ß signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease

Leikas J V, Kohtala S, Theilmann W, Jalkanen A J, Forsberg M M, Rantamäki T, 2017, Journal of neurochemistry, 142, 3, 456-463. A1 Journal article (refereed), original research

Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

Leikas JV, Kääriäinen TM, Jalkanen AJ, Lehtonen M, Rantamäki T, Forsberg MM, 2017, Journal of neuroscience research, 95, 9, 1858-1870. A1 Journal article (refereed), original research

Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Are Elevated in Severe Pre-Eclampsia

Jalkanen V, Tihtonen K, Jalkanen K, Jalkanen AJ, Uotila J, Karlsson S, 2016, Journal of clinical gynecology and obstetrics, 5, 4, 101-105. A1 Journal article (refereed), original research

Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

Gynther Mikko, Kääriäinen Tiina M, Hakkarainen Jenni J, Jalkanen Aaro J, Petsalo Aleksanteri, Lehtonen Marko, Peura Lauri, Kurkipuro Jere, Samaranayake Haritha, Yla-Herttuala Seppo, Rautio Jarkko, Forsberg Markus M, 2014, Drug metabolism and disposition, 2015; 43, 140-146. A1 Journal article (refereed), original research

Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex

Jalkanen Aaro J, Leikas Juuso V, Forsberg Markus M, 2014, Neuroscience letters, 579, 110-113. A1 Journal article (refereed), original research

Skitsofrenian sosiaalisten ja kognitiivisten oireiden uudet mallit ja hoitokonseptit

Forsberg Markus, Ihalainen Jouni, Savolainen Katja, Jalkanen Aaro, 2014, Dosis, 30, 3, 192. B1 Non-refereed journal articles

KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase

Jalkanen Aaro J, Leikas Juuso V, Forsberg Markus M, 2013, Basic and clinical pharmacology and toxicology, 2014:114, 460-463. A1 Journal article (refereed), original research

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum

Jalkanen Aaro J, Piepponen T. Petteri, Hakkarainen Jenni J, De Meester Ingrid, Lambeir Anne-Marie, Forsberg Markus M, 2012, Neurochemistry international, 60, 301-309. A1 Journal article (refereed), original research

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat

Jalkanen Aaro J, Hakkarainen Jenni J, Lehtonen Marko, Venäläinen Tetta, Kääriäinen Tiina M, Jarho Elina, Suhonen Marjukka, Forsberg Markus M, 2011, Basic and clinical pharmacology and toxicology, 109, 443-451. A1 Journal article (refereed), original research

Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum

Jalkanen Aaro J, Savolainen Katja, Forsberg Markus M, 2011, Neuroscience letters, 502, 107-111. A1 Journal article (refereed), original research

Brain uptake of ketoprofen–lysine prodrug in rats

Gynther, Mikko; Jalkanen, Aaro; Lehtonen, Marko; Forsberg, Markus; Laine, Krista; Ropponen, Jarmo; Leppänen, Jukka; Knuuti, Johanna; Rautio, Jarkko, 2010, International journal of pharmaceutics, 399, 1-2, 121-128. A1 Journal article (refereed), original research

Comparison of in vitro cell models in predicting in vivo brain entry of drugs

Hakkarainen, Jenni J; Jalkanen, Aaro J; Kääriäinen, Tiina M; Keski-Rahkonen, Pekka; Venäläinen, Tetta; Hokkanen, Juho; Mönkkönen, Jukka; Suhonen, Marjukka; Forsberg, Markus M, 2010, International journal of pharmaceutics, 402, 1-2, 27-36. A1 Journal article (refereed), original research

Different effects of scopolamine and inhibition of prolyl oligopeptidase on mnemonic and motility functions of young and 8- to 9-month-old rats in the radial-arm maze

Peltonen I, Jalkanen AJ, Sinervä V, Puttonen KA & Männistö P, 2010, Basic and clinical pharmacology and toxicology, 106, 4, 280-287. A1 Journal article (refereed), original research

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: A retrograde neurotracing study in the rat brain

Myöhänen TT, Kääriäinen TM, Jalkanen AJ, Piltonen M, Männistö PT, 2009, Neuroscience letters, 450, 201-205. A1 Journal article (refereed), original research

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

Jalkanen AJ, Puttonen KA, Venäläinen JI, Sinervä V, Mannila A, Ruotsalainen S, Jarho EM, Wallén EAA, Männistö PT, 2007, Basic and clinical pharmacology and toxicology, 100, 132-138. A1 Journal article (refereed), original research

Prolyl oligopeptidase: A potential target for the treatment of cognitive disorders

Männistö PT, Venäläinen J, Jalkanen A, Garcia-Horsman JA, 2007, Drug news and perspectives, 20, 5, 285-351. A2 Review article, Literature review, Systematic review

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors

Venäläinen JI, Garcia-Horsman JA, Forsberg MM, Jalkanen A, Wallén EAA, Jarho EM, Christiaans JAM, Gynther J, Männistö PT, 2006, Biochemical pharmacology, 71, 5, 683-692. A1 Journal article (refereed), original research

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A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery

Altered Retinal Dopamine Homeostasis in Murine Models of Retinitis Pigmentosa

Sodium-Dependent Multivitamin Transporter Facilitates Brain and Neuronal Uptake of a Creatine Analogue

A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation

Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas

Brain-targeted Jedi1 and Jedi2 derivatives as potent enhancers of Piezo1 ion channel activity

Progressive rod bipolar cell loss, ubiquitin accumulation, and subretinal drusenoid deposits in Cln3Δex7/8 mice: New insights into juvenile neuronal ceroid lipofuscinosis pathogenesis

Estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise

The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

Altering distribution profile of palbociclib by its prodrugs

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon

Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Efflux Transporter Inhibitors Can Improve the Brain Uptake and Apoptosis-Inducing Effects of Vinblastine in Cancer Cells

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

Ravitsemusongelmille altistavat lääkkeet iäkkäillä

Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone

Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease

Extracellular Prolyl Oligopeptidase Derived from Activated Microglia is a Potential Neuroprotection Target.

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats

Brief isoflurane anesthesia regulates striatal AKT-GSK3ß signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease

Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Are Elevated in Severe Pre-Eclampsia

Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex

Skitsofrenian sosiaalisten ja kognitiivisten oireiden uudet mallit ja hoitokonseptit

KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat

Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum

Brain uptake of ketoprofen–lysine prodrug in rats

Comparison of in vitro cell models in predicting in vivo brain entry of drugs

Different effects of scopolamine and inhibition of prolyl oligopeptidase on mnemonic and motility functions of young and 8- to 9-month-old rats in the radial-arm maze

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: A retrograde neurotracing study in the rat brain

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

Prolyl oligopeptidase: A potential target for the treatment of cognitive disorders

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors