Anna-Kaisa Ruotsalainen
Senior Researcher
Principal Investigator, Senior Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
My research group explores how cells adapt their metabolism under stress and how these changes influence tissue repair and regeneration in cardiometabolic diseases. We aim to uncover the underlying mechanisms to drive the development of therapies that resolve inflammation and fibrosis and improves tissue regeneration, ultimately improving treatment options for cardiovascular and chronic liver diseases. As part of the GeneCellNano Flagship Program, we also strive to develop RNA therapies for the treatment of cardiometabolic diseases. We are also part of MSCA MIRACLE Doctoral Network where we aim to better understand the metabolic programming in macrophages and its impact on atherosclerosis and cardiac fibrosis.
Research groups
Activities
www.satyry.fi
www.genecellnano.fi
Publications
24/24 items-
Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice
Törmä, Diana; Suoranta, Tuisku; Rinta‐Harri, Mimmi; Hytönen, Jarkko; Ylä‐Herttuala, Seppo; Ruotsalainen, Anna‐Kaisa, 2026, Apmis, 134, 1, e70132. A1 Journal article (refereed), original research -
The co-delivery of Programmed Death 1 ligands enhances and prolongs rAAV-mediated gene expression in pre-immunized mice
Käyhty, Piia; Nieminen, Tiina; Eriksson, Reetta AE.; Tumelius, Ritva; Tawfek, Ahmed; Laidinen, Svetlana; Ruotsalainen, Anna-Kaisa; Bailey, Aubrey; Galibert, Lionel; Lesch, Hanna P; Ylä-Herttuala, Seppo; Airenne, Kari J, 2026, Gene therapy, [Published: 09 January 2026], 1-11. A1 Journal article (refereed), original research -
Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia
Kettunen, Sanna; Slita, Anna; Suoranta, Tuisku; Räty, Iida; Laidinen, Svetlana; Ylä‐Herttuala, Elias; Ruotsalainen, Anna‐Kaisa; Ylä‐Herttuala, Seppo, 2025, Physiological reports, 13, 10, 1-15. A1 Journal article (refereed), original research -
Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis
Örd, Tiit; Palani, Senthil; Giroud Gerbetant, Judith; Bodoy, Susanna; Lönnberg, Tapio; Niskanen, Henri; Ravindran, Aarthi; Holappa, Lari; Chemaly, Melody; Taipale, Mari; Õunap, Kadri; Haikonen, Retu; Talukdar, Husain; Sukhavasi, Katyayani; Liljenbäck, Heidi; Virta, Jenni; Ruotsalainen, Anna-Kaisa; Pierrot-Blanchet, Clara; Miner, Maxwell W G; Moisio, Olli; Rajala, Noora; Li, Xiang-Guo; Low, Philip S; Saraste, Antti; Heinäniemi, Merja; Ylä-Herttuala, Seppo; Björkegren, Johan L M; Hedin, Ulf; Matic, 2025, Cardiovascular research, 121, 16, 2503-2519. A1 Journal article (refereed), original research -
The mechanisms of Chr.9p21.3 risk locus in coronary artery disease – where are we today?
Ruotsalainen, Anna-Kaisa; Kettunen, Sanna; Suoranta, Tuisku; Kaikkonen, Minna U; Ylä-Herttuala, Seppo; Aherrahrou, Rédouane, 2025, American journal of physiology : heart and circulatory physiology, 328, 2, H196-H208. A2 Review article, Literature review, Systematic review -
Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice
Kettunen, Sanna; Suoranta, Tuisku; Beikverdi, Sadegh; Heikkilä, Minja; Slita, Anna; Räty, Iida; Ylä-Herttuala, Elias; Öörni, Katariina; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo, 2024, Cells, 13, 11, 983. A1 Journal article (refereed), original research -
Ex vivo imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T1- and T1ρ-mapping magnetic resonance imaging in mice
Räty, Iida; Aarnio, Antti; Nissi, Mikko J; Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Laidinen, Svetlana; Ylä-Herttuala, Seppo; Ylä-Herttuala, Elias, 2024, European heart journal : imaging methods and practice, 3, 1, 1-10. A1 Journal article (refereed), original research -
Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity
Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Örd, Tiit; Suoranta, Tuisku; Heikkilä, Janne; Kaikkonen, Minna U.; Laham-Karam, Nihay; Ylä-Herttuala, Seppo, 2023, Frontiers in cardiovascular medicine, 10, 1113890. A1 Journal article (refereed), original research -
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Velidendla, Bharadwaja; Niskanen, Einari; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Heikkinen, Sami, 2023, Nucleic acids research, 52, 6, 2904-2923. A1 Journal article (refereed), original research -
Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice
Koponen, Markus; Rysä, Jaana; Ruotsalainen, Anna-Kaisa; Kärkkäinen, Olli; Juvonen, Risto O, 2023, Journal of nutrition and metabolism, 2023, 5599789. A1 Journal article (refereed), original research