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Anna-Kaisa Ruotsalainen

Anna-Kaisa Ruotsalainen

Senior Researcher

A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences

[email protected]

Information Publications

In my team, we investigate the regulatory mechanisms of metabolism and inflammatory activation in cardiometabolic diseases, aiming to gain new insights into the interaction between cellular metabolism and tissue homeostasis. As part of the GeneCellNano Flagship Program, we also strive to develop RNA therapies for the treatment of cardiometabolic diseases, particularly to regulate liver lipid metabolism and inflammatory cell activation.

Research groups

Molecular Medicine 01.01.1995 -

Activities

www.satyry.fi

www.genecellnano.fi

Keywords

atherosclerosis cardiovascular diseases lipidmetabolism low-grade inflammation macrophages metabolic diseases mouse models

Publications

21/21 items

Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia
Kettunen, Sanna; Slita, Anna; Suoranta, Tuisku; Räty, Iida; Laidinen, Svetlana; Ylä‐Herttuala, Elias; Ruotsalainen, Anna‐Kaisa; Ylä‐Herttuala, Seppo, 2025, Physiological reports, 13, 10, 1-15. A1 Journal article (refereed), original research
The mechanisms of Chr.9p21.3 risk locus in coronary artery disease – where are we today?
Ruotsalainen, Anna-Kaisa; Kettunen, Sanna; Suoranta, Tuisku; Kaikkonen, Minna U; Ylä-Herttuala, Seppo; Aherrahrou, Rédouane, 2025, American journal of physiology : heart and circulatory physiology, 328, 2, H196-H208. A2 Review article, Literature review, Systematic review
Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice
Kettunen, Sanna; Suoranta, Tuisku; Beikverdi, Sadegh; Heikkilä, Minja; Slita, Anna; Räty, Iida; Ylä-Herttuala, Elias; Öörni, Katariina; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo, 2024, Cells, 13, 11, 983. A1 Journal article (refereed), original research
Ex vivo imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T1- and T1ρ-mapping magnetic resonance imaging in mice
Räty, Iida; Aarnio, Antti; Nissi, Mikko J; Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Laidinen, Svetlana; Ylä-Herttuala, Seppo; Ylä-Herttuala, Elias, 2024, European heart journal : imaging methods and practice, 3, 1, 1-10. A1 Journal article (refereed), original research
Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity
Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Örd, Tiit; Suoranta, Tuisku; Heikkilä, Janne; Kaikkonen, Minna U.; Laham-Karam, Nihay; Ylä-Herttuala, Seppo, 2023, Frontiers in cardiovascular medicine, 10, 1113890. A1 Journal article (refereed), original research
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Velidendla, Bharadwaja; Niskanen, Einari; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Heikkinen, Sami, 2023, Nucleic acids research, 2024; 52, 6, 2904-2923. A1 Journal article (refereed), original research
Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice
Koponen, Markus; Rysä, Jaana; Ruotsalainen, Anna-Kaisa; Kärkkäinen, Olli; Juvonen, Risto O, 2023, Journal of nutrition and metabolism, 2023, 5599789. A1 Journal article (refereed), original research
RNA interference-based therapies for the control of atherosclerosis risk factors
Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo, 2022, Current opinion in cardiology, 37, 4, 364-371. A2 Review article, Literature review, Systematic review
Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice
Weisell, Jonna; Ruotsalainen, Anna-Kaisa; Näpänkangas, Juha; Jauhiainen, Matti; Rysä, Jaana, 2021, Scientific reports, 11, 1, 3014. A1 Journal article (refereed), original research
Novel RNAi-Based Therapies for Atherosclerosis
Ruotsalainen, Anna-Kaisa; Mäkinen, Petri; Ylä-Herttuala, Seppo, 2021, Current atherosclerosis reports, 23, 8, 45. A2 Review article, Literature review, Systematic review
SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice
Gurzeler, Erika; Ruotsalainen, Anna-Kaisa; Laine, Anssi; Valkama, Teemu; Kettunen, Sanna; Laakso, Markku; Ylä-Herttuala, Seppo, 2021, PLoS ONE, 16, 11, e025840. A1 Journal article (refereed), original research
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models
Cedo, Lidia; Metso, Jari; Santos, David; García-León, Annabel; Plana, Nuria; Sabate-Soler, Sonia; Rotllan, Noemi; Rivas-Urbina, Andrea; Mendez-Lara, Karen A; Tondo, Mireia; Girona, Josefa; Julve, Josep; Pallarès, Victor; Benitez-Amado, Aleyda; Llorente Cortes, Vicenta; Pérez, Antonio; Gómez-Coronado, Diego; Ruotsalainen, Anna-Kaisa; Levonen, Anna-Liisa; Sanchez-Quesada, Jose Luis et al., 2020, Circulation research, 127, 6, 778-792. A1 Journal article (refereed), original research
Nucleic Acid-Based Therapies for Atherosclerosis
Mäkinen, P; Ruotsalainen, AK; Ylä-Herttuala, S, 2020, Current atherosclerosis reports, 22, 2, 10. A2 Review article, Literature review, Systematic review
Characterizing valve dynamics in mice by high-resolution cine-MRI
Weisell, J; Ruotsalainen, AK; Laakso, H; Ylä-Herttuala, E; Näpänkangas, J; Levonen, AL; Liimatainen, T; Rysä, J, 2019, Nmr in biomedicine, 32, 8, e4108. A1 Journal article (refereed), original research
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A], 2018, Redox biology, 2019; 20, 1-12. A1 Journal article (refereed), original research
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice
Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa, 2018, Cardiovascular research, 2019; 115, 1, 243-254. A1 Journal article (refereed), original research
The role of transcription factor Nrf2 in atherogenesis and hepatic steatosis in hypercholesterolemic mouse models
Ruotsalainen, Anna-Kaisa, 2018, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)
Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells
Kansanen Emilia, Kuosmanen Suvi M, Ruotsalainen Anna-Kaisa, Hynynen Heidi, Levonen Anna-Liisa, 2017, Molecular pharmacology, 92, 4, 481-490. A1 Journal article (refereed), original research
The absence of macrophage Nrf2 promotes early atherogenesis
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL, 2013, Cardiovascular research, 2013 Apr 1;98(1), 107-15. A1 Journal article (refereed), original research
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T, 2013, Journal of neuroinflammation, 2013 Aug 20;10(1):102. A1 Journal article (refereed), original research
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL, 2012, Cancer research, 2012 Oct 9. [Epub ahead of print]. A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Anna-Kaisa Ruotsalainen

Research groups

Activities

Keywords

Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia

The mechanisms of Chr.9p21.3 risk locus in coronary artery disease – where are we today?

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice

Ex vivo imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T1- and T1ρ-mapping magnetic resonance imaging in mice

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice

RNA interference-based therapies for the control of atherosclerosis risk factors

Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice

Novel RNAi-Based Therapies for Atherosclerosis

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models

Nucleic Acid-Based Therapies for Atherosclerosis

Characterizing valve dynamics in mice by high-resolution cine-MRI

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice

The role of transcription factor Nrf2 in atherogenesis and hepatic steatosis in hypercholesterolemic mouse models

Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells

The absence of macrophage Nrf2 promotes early atherogenesis

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment