Eppu Manninen
Postdoctoral Researcher
Magnetic resonance imaging in aging
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
I work as a postdoctoral researcher in the NOVEL MSCA Postdoctoral Programme. I research magnetic resonance imaging (MRI)-based biomarkers for aging and memory impairment. In my project, I utilize existing datasets and apply novel multidimensional MRI and zero echo time functional MRI methods to detect aging-related changes and diseases.
I completed my dissertation “Magnetic resonance imaging-based biomarkers of epilepsy in a rat model of traumatic brain injury” in 2022 at the University of Eastern Finland. During my thesis work, I collected and analyzed a large collection of MRI data, gaining a good working knowledge of MRI.
Publications
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Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury
Kyyriäinen, Jenni; Andrade, Pedro; Ekolle Ndode-Ekane, Xavier; Manninen, Eppu; Hämäläinen, Elina; Rauramaa, Tuomas; Heiskanen, Mette; Puhakka, Noora; Immonen, Riikka; Pitkänen, Asla, 2024, Epilepsy research, 200, 107301. A1 Journal article (refereed), original research -
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study
Heiskanen, Mette; Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Puhakka, Noora; Gupta, Shalini Das; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Manninen, Eppu; Smith, Gregory; Brady, Rhys D.; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R.; Jones, Nigel C.; Shultz, Sandy R.; Harris, Neil G.; Wright, David K.; Gröhn, Olli; Staba, Richard J.; O'Brien, Terence J.; Pitkänen, Asla, 2024, Epilepsia, 66, 3, 870-885. A1 Journal article (refereed), original research -
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury
Heiskanen, Mette; Banuelos, Ivette; Manninen, Eppu; Andrade, Pedro; Hämäläinen, Elina; Puhakka, Noora; Pitkänen, Asla, 2024, Epilepsia, 65, 12, 3703-3716. A1 Journal article (refereed), original research -
Axon fiber orientation as the source of T1 relaxation anisotropy in white matter: A study on corpus callosum in vivo and ex vivo
Kauppinen, Risto A; Thothard, Jeromy; Leskinen, Henri PP; Pisharady, Pramod K; Manninen, Eppu; Kettunen, Mikko; Lenglet, Christophe; Gröhn, Olli HJ; Garwood, Michael; Nissi, Mikko J, 2023, Magnetic resonance in medicine, 90, 2, 708-721. A1 Journal article (refereed), original research -
Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury
Chary, Karthik; Manninen, Eppu; Claessens, Jade; Ramirez-Manzanares, Alonso; Gröhn, Olli; Sierra, Alejandra, 2023, Scientific reports, 13, 2219. A1 Journal article (refereed), original research -
Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort
Heiskanen, Mette; Das Gupta, Shalini; Mills, James D; van Vliet, Erwin A; Manninen, Eppu; Ciszek, Robert; Andrade, Pedro; Puhakka, Noora; Aronica, Eleonora; Pitkänen, Asla, 2023, International journal of molecular sciences, 24, 3, 2823. A1 Journal article (refereed), original research -
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1
Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla, 2023, Epilepsia, 65, 2, 511-526. A1 Journal article (refereed), original research -
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S, 2023, Epilepsy research, 195, 107201. A1 Journal article (refereed), original research -
Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies
Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla, 2023, Epilepsy research, 199, 107263. A1 Journal article (refereed), original research -
Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury
Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla, 2022, Biomedicines, 10, 11, 2721. A1 Journal article (refereed), original research