Esa Hämäläinen

Adipose Tissue Sex Steroids in Postmenopausal Women with and without Menopausal Hormone Therapy

Hetemäki, Natalia; Robciuc, Alexandra; Vihma, Veera; Haanpää, Mikko; Hämäläinen, Esa; Tikkanen, Matti J; Mikkola, Tomi S; Savolainen-Peltonen, Hanna. 2025. Journal of clinical endocrinology and metabolism. 110: 511-522 A1 Journal article (refereed), original research

Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer

Eskelinen, Maaret; Selander, Tuomas; Pulkkinen, Jukka; Kaarniranta, Kai; Hämäläinen, Esa; Eskelinen, Matti. 2025. Anticancer research. 45: 667-675 A1 Journal article (refereed), original research

Associations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts

Girchenko, Polina; Lahti-Pulkkinen, Marius; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia M; Kajantie, Eero; Räikkönen, Katri. 2024. Bmc pregnancy and childbirth. 24: A1 Journal article (refereed), original research

Blood Interleukin-18 (IL-18) and IL-18 Binding Protein (IL-18BP) Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer

Eskelinen, Maaret; Selander, Tuomas; Pulkkinen, Jukka; Hämäläinen, Esa; Eskelinen, Matti. 2024. Anticancer research. 44: 2039-2046 A1 Journal article (refereed), original research

Brief Pain Inventory (BPI) Pain Survey Versus Cysteine Protease Caspase-1 (Casp1) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer

Eskelinen, Maaret; Selander, Tuomas; Saimanen, Iina; Pulkkinen, Jukka; Hämäläinen, Esa; Eskelinen, Matti. 2024. Anticancer research. 44: 3463-3471 A1 Journal article (refereed), original research

Correlation Between Blood Levels of Cysteine Protease Caspase-1 (Casp1) and Pain Scores (NRS) Post-surgery: A Prospective Randomized Study of Patients With Cholelithiasis

Eskelinen, Maaret; Selander, Tuomas; Pulkkinen, Jukka; Holopainen, Anu; Hämäläinen, Esa; Eskelinen, Matti. 2024. Anticancer research. 44: 2997-3003 A1 Journal article (refereed), original research

Effects of vaginal estrogen on serum estradiol during aromatase inhibitor therapy in breast cancer patients with vulvovaginal atrophy: a prospective trial

Faltinová, Mária; Vehmanen, Leena; Lyytinen, Heli; Savolainen-Peltonen, Hanna; Virtanen, Anni; Haanpää, Mikko; Hämäläinen, Esa; Tiitinen, Aila; Mattson, Johanna. 2024. Breast cancer research and treatment. [Published: 27 December 2024]: 1-11 A1 Journal article (refereed), original research

Quantification of multiple steroid hormones in serum and human breast cancer tissue by liquid chromatography-tandem mass spectrometry analysis

Wang, Feng; Eikeland, Eline; Reidunsdatter, Randi J; Hagen, Lars; Engstrøm, Monica J; Geisler, Jürgen; Haanpää, Mikko; Hämäläinen, Esa; Giskeødegård, Guro F; Bathen, Tone F. 2024. Frontiers in oncology. 14: . 1383104 A1 Journal article (refereed), original research

Serum Hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein a but does not serve as an independent marker for preeclampsia

Heinosalo, Taija; Saarinen, Niina; Biehl, Alexander; Rytkönen, Kalle T; Villa, Pia M; Juhila, Juuso; Koskimies, Pasi; Laiho, Asta; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Elo, Laura L; Laivuori, Hannele; Poutanen, Matti. 2024. Biology of reproduction. 111: 436-447 A1 Journal article (refereed), original research

A Possible Role of Interleukin-18 Binding Protein in Immune Regulation of Postoperative Pain: A Prospective Randomized Clinical Trial

Eskelinen, Maaret; Saimanen, Iina; Pulkkinen, Jukka; Selander, Tuomas; Holopainen, Anu; Hämäläinen, Esa; Eskelinen, Matti. 2023. Anticancer research. 43: 3113-3119 A1 Journal article (refereed), original research

Effect of external sleep disturbance on sleep architecture in perimenopausal and postmenopausal women

Virtanen, I; Polo-Kantola, P; Turpeinen, U; Hämäläinen, E; Kalleinen, N. 2023. Climacteric. 26: 103-109 A1 Journal article (refereed), original research

Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC–MS/MS (liquid chromatography–tandem mass spectrometry) method for estrogen measurement

Faltinová, Mária; Vehmanen, Leena; Lyytinen, Heli; Haanpää, Mikko; Hämäläinen, Esa; Tiitinen, Aila; Blomqvist, Carl; Mattson, Johanna. 2023. Breast cancer research and treatment. 201: 425-435 A1 Journal article (refereed), original research

Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes

Sormunen-Harju, Heidi; Huvinen, Emilia; Girchenko, Polina V; Kajantie, Eero; Villa, Pia M; Hämäläinen, Esa K; Lahti-Pulkkinen, Marius; Laivuori, Hannele; Räikkönen, Katri; Koivusalo, Saila B. 2023. Journal of clinical endocrinology and metabolism. 108: 2862-2870 A1 Journal article (refereed), original research

Non-suppression of renin by renal cysts in a subset of patients with primary aldosteronism - a prospective observational single center study

Ylänen, Antero; Pörsti, Ilkka; Nevalainen, Riikka; Hinkka, Tero; Huhtala, Heini; Matikainen, Niina; Hämäläinen, Esa; Niemelä, Onni; Nevalainen, Pasi, I. 2023. European journal of endocrinology. 189: 58-66 A1 Journal article (refereed), original research

Effects of rifampicin on porphyrin metabolism in healthy volunteers

Tolonen, Hanna; Ranta, Sirpa; Hämäläinen, Esa; Kauppinen, Raili; Hukkanen, Janne. 2022. Basic and clinical pharmacology and toxicology. 2023; 132: 281-291 A1 Journal article (refereed), original research

Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores and the Number of Analgesic Doses Following Surgery

Eskelinen, Maaret; Saimanen, Iina; Selander, Tuomas; Holopainen, Anu; Aspinen, Samuli; Hämäläinen, Esa; Eskelinen, Matti. 2022. Anticancer research. 42: 5521-5526 A1 Journal article (refereed), original research

Maternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children

Girchenko, Polina; Lahti-Pulkkinen, Marius; Lipsanen, Jari; Heinonen, Kati; Lahti, Jari; Rantalainen, Ville; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia M.; Kajantie, Eero; Räikkönen, Katri. 2022. Molecular psychiatry. 27: 4653-4661 A1 Journal article (refereed), original research

Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children

Girchenko, Polina; Robinson, Rachel; Rantalainen, Ville Juhani; Lahti-Pulkkinen, Marius; Heinonen-Tuomaala, Kati; Lemola, Sakari; Wolke, Dieter; Schnitzlein, Daniel; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia M.; Kajantie, Eero; Räikkönen, Katri. 2022. Scientific reports. 12: . 947 A1 Journal article (refereed), original research

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Pervjakova, Natalia; Moen, Gunn-Helen; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P; Allard, Catherine; Beaumont, Robin N; Canouil, Mickaël; Hatem, Gad; Heiskala, Anni; Joensuu, Anni; Karhunen, Ville; Kwak, Soo Heon; Lin, Frederick T J; Liu, Jun; Rifas-Shiman, Sheryl; Tam, Claudia H; Tam, Wing Hung; Thorleifsson, Gudmar; Andrew, Toby; Auvinen, Juha; Bhowmik, Bishwajit; Bonnefond, Amélie; Delahaye, Fabien; Demirkan, Ayse; Froguel, Philippe; Haller-Kikkatalo, Kadri; Hardardottir, Hildur. 2022. Human molecular genetics. 31: 3377-3391 A1 Journal article (refereed), original research

Primaarin aldosteronismin diagnostiikka ja hoito

Nevalainen, Pasi I; Ylänen, Antero; Hämäläinen, Esa; Pörsti, Ilkka; Matikainen, Niina . 2022. Duodecim. 138: 1721-1732 A2 Review article, Literature review, Systematic review

Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia

Joenväärä, Sakari; Holm, Matilda; Saraswat, Mayank; Agarwal, Rahul; Tohmola, Tiialotta; Kajantie, Eero; Räikkönen, Katri; Laivuori, Hannele; Villa, Pia M.; Hämäläinen, Esa; Renkonen, Risto. 2022. Translational medicine communications. 7: . 1 A1 Journal article (refereed), original research

Adipose tissue estrogen production and metabolism in premenopausal women

Hetemäki, Natalia; Mikkola, Tomi S; Tikkanen, Matti J; Wang, Feng; Hämäläinen, Esa; Turpeinen, Ursula; Haanpää, Mikko; Vihma, Veera; Savolainen-Peltonen, Hanna. 2021. Journal of steroid biochemistry and molecular biology. 209: 105849 A1 Journal article (refereed), original research

Longitudinal metabolic profiling of maternal obesity, gestational diabetes and hypertensive pregnancy disorders

Kivelä, Jemina; Sormunen-Harju, Heidi; Girchenko, Polina V; Huvinen, Emilia; Stach-Lempinen, Beata; Kajantie, Eero; Villa, Pia M; Reynolds, Rebecca M; Hämäläinen, Esa K; Lahti-Pulkkinen, Marius; Murtoniemi, Katja K; Laivuori, Hannele; Eriksson, Johan G; Räikkönen, Katri; Koivusalo, Saila B. 2021. Journal of clinical endocrinology and metabolism. 106: e4372-e4388 A1 Journal article (refereed), original research

Maternal antenatal stress and mental and behavioral disorders in their children

Tuovinen, Soile; Lahti-Pulkkinen, Marius; Girchenko, Polina; Heinonen, Kati; Lahti, Jari; Reynolds, Rebecca M; Hämäläinen, Esa; Villa, Pia M; Kajantie, Eero; Laivuori, Hannele; Raikkonen, Katri. 2021. Journal of affective disorders. 278: 57-65 A1 Journal article (refereed), original research

Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial

Faltinova, Maria; Vehmanen, Leena; Lyytinen, Heli; Haanpää, Mikko; Hämäläinen, Esa; Tiitinen, Aila; Blomqvist, Carl; Mattson, Johanna. 2021. Breast cancer research and treatment. 187: 769-775 A1 Journal article (refereed), original research

Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women

Keikkala, Elina; Forstén, Janina; Ritvos, Olli; Stenman, Ulf-Håkan; Kajantie, Eero; Hämäläinen, Esa; Räikkönen, Katri; Villa, Pia M; Laivuori, Hannele. 2021. Pregnancy hypertension. 25: 116-122 A1 Journal article (refereed), original research

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders

Suarez, Anna; Lahti, Jari; Lahti-Pulkkinen, Marius; Girchenko, Polina; Czamara, Darina; Arloth, Janine; Malmberg, Anni Lk; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M; Reynolds, Rebecca M; Provençal, Nadine; Binder, Elisabeth B; Räikkönen, Katri. 2020. Neurobiology of stress. 13: 100275 A1 Journal article (refereed), original research

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Yeung, Edwina H; Guan, Weihua; Zeng, Xuehuo; Salas, Lucas A; Mumford, Sunni L; de Prado Bert, Paula; van Meel, Evelien R; Malmberg, Anni; Sunyer, Jordi; Duijts, Liesbeth; Felix, Janine F; Czamara, Darina; Hämäläinen, Esa; Binder, Elisabeth B; Räikkönen, Katri; Lahti, Jari; London, Stephanie J; Silver, Robert M; Schisterman, Enrique F. 2020. Clinical epigenetics. 12: 60 A1 Journal article (refereed), original research

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

Provençal, Nadine; Arloth, Janine; Cattaneo, Annamaria; Anacker, Christoph; Cattane, Nadia; Wiechmann, Tobias; Röh, Simone; Ködel, Maik; Klengel, Torsten; Czamara, Darina; Müller, Nikola S; Lahti, Jari; PREDO team; Räikkönen, Katri; Pariante, Carmine M; Binder, Elisabeth B. 2020. Proceedings of the National Academy of Sciences of the United States of America. 117: 23280-23285 A1 Journal article (refereed), original research

Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children

Lahti-Pulkkinen, Marius; Girchenko, Polina; Tuovinen, Soile; Sammallahti, Sara; Reynolds, Rebecca M; Lahti, Jari; Heinonen, Kati; Lipsanen, Jari; Hämäläinen, Esa; Villa, Pia M; Kajantie, Eero; Laivuori, Hannele; Räikkönen, Katri. 2020. Hypertension. 75: 1429-1438 A1 Journal article (refereed), original research

Persistently High Levels of Maternal Antenatal Inflammation Are Associated With and Mediate the Effect of Prenatal Environmental Adversities on Neurodevelopmental Delay in the Offspring

Girchenko, Polina; Lahti-Pulkkinen, Marius; Heinonen, Kati; Reynolds, Rebecca M; Laivuori, Hannele; Lipsanen, Jari; Villa, Pia M; Hämäläinen, Esa; Kajantie, Eero; Lahti, Jari; Räikkönen, Katri. 2020. Biological psychiatry. 87: 898-907 A1 Journal article (refereed), original research

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Korhonen, Kati; Unkila-Kallio, Leila; Alfthan, Henrik; Hämäläinen, Esa; Tiitinen, Aila; Mikkola, Tomi; Tapanainen, Juha; Savolainen-Peltonen, Hanna. 2020. Archives of gynecology and obstetrics. 301: 1569-1578 A1 Journal article (refereed), original research

Polygenic Prediction of the Risk of Perinatal Depressive Symptoms

Rantalainen, V; Binder, EB; Lahti-Pulkkinen, M; Czamara, D; Laivuori, H; Villa, PM; Girchenko, P; Kvist, T; Hämäläinen, E; Kajantie, E; Lahti, J; Räikkönen, K. 2020. Depression and anxiety. 37: 862-875 A1 Journal article (refereed), original research

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Bramham, Kate; Villa, Pia M; Joslin, Jennifer R; Laivuori, Hannele; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Pesonen, Anukatriina; Seed, Paul; Dalton, R Neil; Turner, Charles; Wong, Max; Von Dadelszen, Peter; Roberts, James M; Poston, Lucilla; Chappell, Lucy C. 2020. Hypertension in pregnancy. 39: 326-335 A1 Journal article (refereed), original research

Saltatory Pattern of Fetal Heart Rate during Labor Is a Sign of Fetal Hypoxia

Tarvonen, Mikko; Sainio, Susanna; Hämäläinen, Esa; Hiilesmaa, Vilho; Andersson, Sture; Teramo, Kari. 2020. Neonatology. 117: 111-117 A1 Journal article (refereed), original research

Kliniskt-kemisk avdelning vid Kuopio universitetssjukhus samt institutionen för klinisk kemi vid Kuopio universitet verksamheten under åren 1959-1995

Penttilä I, Hämäläinen E, Puhakainen E, Rantanen T, Sahlstein R. 1996. Klinisk biokemi i norden. 8: 15-20 D1 Article in a trade journal

Diet and urinary estrogen profile in various populations. A preliminary report

Adlercreutz H, Gorbach SL, Goldin BR, Woods MN, Dwyer JT, Höckerstedt K, Wähälä K, Hase T, Hämäläinen E, Fotsis T. 1994. Polycyclic aromatic compounds. 6: 261-273 A1 Journal article (refereed), original research

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Publications

Adipose Tissue Sex Steroids in Postmenopausal Women with and without Menopausal Hormone Therapy

Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer

Associations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts

Blood Interleukin-18 (IL-18) and IL-18 Binding Protein (IL-18BP) Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer

Brief Pain Inventory (BPI) Pain Survey Versus Cysteine Protease Caspase-1 (Casp1) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer

Correlation Between Blood Levels of Cysteine Protease Caspase-1 (Casp1) and Pain Scores (NRS) Post-surgery: A Prospective Randomized Study of Patients With Cholelithiasis

Effects of vaginal estrogen on serum estradiol during aromatase inhibitor therapy in breast cancer patients with vulvovaginal atrophy: a prospective trial

Quantification of multiple steroid hormones in serum and human breast cancer tissue by liquid chromatography-tandem mass spectrometry analysis

Serum Hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein a but does not serve as an independent marker for preeclampsia

A Possible Role of Interleukin-18 Binding Protein in Immune Regulation of Postoperative Pain: A Prospective Randomized Clinical Trial

Effect of external sleep disturbance on sleep architecture in perimenopausal and postmenopausal women

Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC–MS/MS (liquid chromatography–tandem mass spectrometry) method for estrogen measurement

Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes

Non-suppression of renin by renal cysts in a subset of patients with primary aldosteronism - a prospective observational single center study

Effects of rifampicin on porphyrin metabolism in healthy volunteers

Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores and the Number of Analgesic Doses Following Surgery

Maternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children

Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Primaarin aldosteronismin diagnostiikka ja hoito

Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia

Adipose tissue estrogen production and metabolism in premenopausal women

Longitudinal metabolic profiling of maternal obesity, gestational diabetes and hypertensive pregnancy disorders

Maternal antenatal stress and mental and behavioral disorders in their children

Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial

Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children

Persistently High Levels of Maternal Antenatal Inflammation Are Associated With and Mediate the Effect of Prenatal Environmental Adversities on Neurodevelopmental Delay in the Offspring

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Polygenic Prediction of the Risk of Perinatal Depressive Symptoms

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Saltatory Pattern of Fetal Heart Rate during Labor Is a Sign of Fetal Hypoxia

Kliniskt-kemisk avdelning vid Kuopio universitetssjukhus samt institutionen för klinisk kemi vid Kuopio universitet verksamheten under åren 1959-1995

Diet and urinary estrogen profile in various populations. A preliminary report