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Embodetect Study Group

Research group
01.01.2022 -
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Information People Publications

Imaging as an aid in understanding stroke etiology

Stroke is the leading cause of long-term disability, the second-leading cause of death, and a major consumer of healthcare resources worldwide. Embolism of cardiac origin is thought to account for around one fifth of ischemic strokes. Approximately 20–25% of all strokes are recurrent and the risk of recurrence can be reduced with early initiation of appropriate secondary prevention. Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30–40% of all ischemic strokes.

Etiological work-up of stroke/transient ischemic attack (TIA) usually includes the parallel use of several imaging modalities that may be time-consuming and expensive when performed in separate sessions.

Our study group investigates whether combined examination of the heart, aorta, and cervicocranial arteries with CT may improve the diagnosis of stroke etiology.

Most cardiac thrombi originate from the left atrial appendage (LAA). An enlarged LAA may predispose to blood coagulation due to slow flow velocity. The study also aims to assess whether LAA and/or left atrium volumetry is helpful in risk stratifications in patients with cryptogenic stroke.

We also investigate the role of inflammation markers and increased visceral fat, intrathoracic fat and pericardial fat in stroke pathogenesis.

Cooperation

    • Antti Muuronen, MD / Junior Researcher
      Visceral adipose tissue and inflammation markers
      Antti.Muuronen ( at ) kuh.fi
    • Miika Korhonen, BM M.Sc.(Tech.) / Junior Researcher
      Left atrial appendage morphology and automatized segmentation
      Miika.Korhonen ( at ) kuh.fi
    • Juha Onatsu, MD / Neurologist
      Clinical perspectives and fife-year follow-up
      Juha.Onatsu ( at ) kuh.fi

Keywords

clinical medicine enlarged LAA imaging inflammation markers ischemic stroke left arterial appendage stroke TIA visceral fat

Professors

Other group members

  • Pirjo Mustonen, Adjunct Professor (KUH)
  • Sakari Simula, Senior Researcher
  • Kari Pulkki, Professor
  • Petri Sipola, Adjunct Professor (KUH)

Publications

15 items