
Inhalation Toxicology Laboratory
The research of the Inhalation Toxicology Laboratory is focused on toxicological effects of inhalable environmental exposures in the immune system. Our aim is to identify the actual causes of health effects by using cell lines, experimental animals and clinical samples. The research is conducted using multidisciplinary approach in collaboration with experts in e.g. aerosol physics, combustion technology, microbiology, epidemiology and modeling.
We study how environmental exposures such as combustion emissions, outdoor and indoor air particulate matter, microbes and chemicals activate toxicological mechanisms leading to adverse health effects. In addition, we are also interested in the protective role of exposure to environmental microbes during childhood, e.g. their effect on the maturation of immune responses and development of asthma and allergies.
Teams
Keywords
Professors
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Marjut Roponen
ProfessorFaculty of Science, Forestry and Technology, Department of Environmental and Biological Sciences -
Pasi Jalava
Associate ProfessorFaculty of Science, Forestry and Technology, Department of Environmental and Biological Sciences
Post-doctoral Researchers
Doctoral Researchers
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Henri Hakkarainen
Doctoral ResearcherFaculty of Science, Forestry and Technology, Department of Environmental and Biological Sciences -
Tarleena Tossavainen
Doctoral ResearcherFaculty of Science, Forestry and Technology, Department of Environmental and Biological Sciences
Visiting researcher
Other group members
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Miisa Kankaanpää
Publications
206 items-
Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers
Illi, S; Depner, M; Pfefferle, PI; Renz, H; Roduit, C; Taft, DH; Kalanetra, KM; Mills, DA; Farquharson, FM; Louis, P; Schmausser-Hechfellner, E; Divaret-Chauveau, A; Lauener, R; Karvonen, AM; Pekkanen, J; Kirjavainen, PV; Roponen, M; Riedler, J; Kabesch, M; Schaub, B; von Mutius, E; PASTURE Study Group. American journal of respiratory and critical care medicine [in press]: -. 2022 -
A review of microbial and chemical assessment of indoor surfaces
Mihucz, Victor G; Ruus, Aime; Raamets, Jane; Wimmerova, Lenká; Vera, Teresa; Bossi, Rossana; Huttunen, Kati. Applied spectroscopy reviews [ePub ahead of print 18 Nov 2021]: 1-73. 2021 -
Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China
He, Zhi-Zhou; Guo, Peng-Yue; Xu, Shu-Li; Zhou, Yang; Jalaludin, Bin; Leskinen, Ari; Knibbs, Luke D; Heinrich, Joachim; Morawska, Lidia; Yim, Steve Hung-Lam; Bui, Dinh; Komppula, Mika; Roponen, Marjut; Hu, Liwen; Chen, Gongbo; Zeng, Xiao-Wen; Yu, Yunjiang; Yang, Bo-Yi; Dong, Guanghui. Environmental science and technology 55 8: 5065-5075. 2021 -
Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
Liu, Lizhi; Bai, Xuan; Martikainen, Maria-Viola; Kårlund, Anna; Roponen, Marjut; Xu, Wujun; Hu, Guoqing; Tasciotti, Ennio; Lehto, Vesa-Pekka. Nature communications 12 1: 5726. 2021 -
Early age exposure to moisture and mould is related to FeNO at the age of 6 years
Tischer, Christina; Karvonen, Anne M; Kirjavainen, Pirkka V; Flexeder, Claudia; Roponen, Marjut; Hyvärinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha. Pediatric allergy and immunology 32 6: 1226-1237. 2021 -
Genotoxic and inflammatory effects of spruce and brown coal briquettes combustion aerosols on lung cells at the air-liquid interface
Ihantola, Tuukka; Hirvonen, Maija-Riitta; Ihalainen, Mika; Hakkarainen, Henri; Sippula, Olli; Tissari, Jarkko; Bauer, Stefanie; Di Bucchianico, Sebastiano; Rastak, Narges; Hartikainen, Anni; Leskinen, Jani; Yli-Pirilä, Pasi; Martikainen, Maria-Viola; Miettinen, Mirella; Suhonen, Heikki; Rönkkö, Teemu J.; Kortelainen, Miika; Lamberg, Heikki; Czech, Hendryk; Martens, Patrick et al. [incl. Jokiniemi,. Science of the total environment 2022; 806 1: 150489. 2021 -
Household solid waste combustion with wood increases particulate trace metal and lung deposited surface area emissions
Timonen, H; Mylläri, F; Simonen, P; Aurela, M; Maasikmets, M; Bloss, M; Kupri, H-L; Vainumäe, K; Lepistö, T; Salo, L; Niemelä, V; Seppälä, S; Jalava, PI; Teinemaa, E; Saarikoski, S; Rönkkö, T. Journal of environmental management 293: 112793. 2021 -
Microbial exposures in moisture-damaged schools and associations with respiratory symptoms in students: A multi-country environmental exposure study
Adams, Rachel I.; Leppänen, Hanna; Karvonen, Anne M.; Jacobs, José; Borràs-Santos, Alicia; Valkonen, Maria; Krop, Esmeralda; Haverinen-Shaughnessy, Ulla; Huttunen, Kati; Zock, Jan-Paul; Hyvärinen, Anne; Heederik, Dick; Pekkanen, Juha; Täubel, Martin. Indoor air 31 6: 1952-1966. 2021 -
Mitogen-activated protein kinase signaling in childhood asthma development and environment-mediated protection
Theodorou, J; Nowak, E; Böck, A; Salvermoser, M; Beerweiler, C; Zeber, K; Kulig, P; Tsang, MS; Wong, CK; Wong, GWK; Roponen, M; Kumbrink, J; Alhamdan, F; Michel, F; Garn, H; Tosevski, V; Schaub, B. Pediatric allergy and immunology 2022; 33 1: e13657. 2021 -
Perfluorooctanesulfonate and perfluorooctanoate exacerbate airway inflammation in asthmatic mice and in vitro
Yang, Mo; Li, Li-Yue; Qin, Xiao-Di; Ye, Xiao-Yan; Yu, Shu; Bao, Qing; Sun, Lin; Wang, Zhi-Bin; Bloom, Michael S; Jalava, Pasi; Hu, Li-Wen; Yu, Hong-Yao; Zeng, Xiao-Wen; Yang, Bo-Yi; Dong, Guang-Hui; Li, Chun-Wei. Science of the total environment 766: 142365. 2021 -
Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China
Guo, Peng-Yue; He, Zhi-Zhou; Jalaludin, Bin; Knibbs, Luke D; Leskinen, Ari; Roponen, Marjut; Komppula, Mika; Jalava, Pasi; Hu, Li-Wen; Chen, Gongbo; Zeng, Xiao-Wen; Yang, Bo-Yi; Dong, Guang-Hui. Journal of the American heart association 10 10: e019063. 2021 -
Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among Healthy Young Adults in Guangzhou, China
Feng, Dan; Cao, Ke; He, Zhi-Zhou; Knibbs, Luke D.; Jalaludin, Bin; Leskinen, Ari; Roponen, Marjut; Komppula, Mika; Jalava, Pasi; Guo, Peng-Yue; Xu, Shu-Li; Yang, Bo-Yi; Hu, Liwen; Zeng, Xiao-Wen; Chen, Gongbo; Yu, Hong-Yao; Lin, Lizi; Dong, Guanghui. Environmental science and technology 55 9: 9. 2021 -
Sisäilma, terveys ja riskikäsitykset
Huttunen, Kati. Ympäristö ja terveys 52 5: 6-13. 2021 -
The characteristics and size of lung-depositing particles vary significantly between high and low pollution traffic environments
Salo, Laura; Hyvärinen, Antti; Jalava, Pasi; Teinilä, Kimmo; Hooda, Rakesh K.; Datta, Arindam; Saarikoski, Sanna; Lintusaari, Henna; Lepistö, Teemu; Martikainen, Sampsa; Rostedt, Antti; Sharma, Ved Prakash; Rahman, Md. Hafizur; Subudhi, Sanjukta; Asmi, Eija; Niemi, Jarkko V.; Lihavainen, Heikki; Lal, Banwari; Keskinen, Jorma; Kuuluvainen, Heino et al.. Atmospheric environment 255: 118421. 2021 -
Toxicological and microbiological characterization of cow stable dust
Martikainen, Maria-Viola; Tossavainen, Tarleena; Täubel, Martin; Wolczkiewicz, Kirsi; Lähde, Anna; Roponen, Marjut. Toxicology in vitro 75: 105202. 2021 -
Toxicological transcriptome of human airway constructs after exposure to indoor air particulate matter: In search of relevant pathways of moisture damage-associated health effects
Nordberg, Maria-Elisa; Täubel, Martin; Heikkinen, Sami; Jalkanen, Kaisa; Köliö, Arto; Stranger, Marianne; Leppanen, Hanna; Hyvärinen, Anne; Huttunen, Kati. Environment international 2022; 158: 106997. 2021 -
Visualising household air pollution: Colorimetric sensor arrays for monitoring volatile organic compounds indoors
Duffy, Emer; Huttunen, Kati; Lahnavik, Roosa; Smeaton, Alan F.; Morrin, Aoife. PLoS ONE 16 10: e0258281. 2021 -
Weathering of Antibacterial Melt-Spun Polyfilaments Modified by Pine Rosin
Kanerva, Mikko; Mensah-Attipoe, Jacob; Puolakka, Arja; Takala, Timo M.; Hyttinen, Marko; Layek, Rama; Palola, Sarianna; Yudin, Vladimir; Pasanen, Pertti; Saris, Per. Molecules 26 4: 876. 2021 -
Air quality intervention during the Nanjing youth olympic games altered PM sources, chemical composition, and toxicological responses
Rönkkö, TJ; Hirvonen, M-R; Happo, MS; Leskinen, A; Koponen, H; Mikkonen, S; Bauer, S; Ihantola, T; Hakkarainen, H; Miettinen, M; Orasche, J; Gu, C; Wang, Q; Jokiniemi, J; Sippula, O; Komppula, M; Jalava, PI. Environmental research 185: 109360. 2020 -
Altistuminen kosteusvaurioituneista taloista kerätyille hiukkasnäytteille aktivoi ilmatiesolukon toksisiin vasteisiin liittyviä geenejä
Nordberg, Maria-Elisa; Täubel, Martin; Leppänen, Hanna; Hyvärinen Anne; Huttunen, Kati / Sisäilmastoseminaari 2020. 2020. 2020 -
Association Between Residential Greenness, Cardiometabolic Disorders, and Cardiovascular Disease Among Adults in China
Yang, Bo-Yi; Hu, Li-Wen; Jalaludin, Bin; Knibbs, Luke D; Markevych, Iana; Heinrich, Joachim; Bloom, Michael S; Morawska, Lidia; Lin, Shao; Jalava, Pasi; Roponen, Marjut; Gao, Meng; Chen, Duo-Hong; Zhou, Yang; Yu, Hong-Yao; Liu, Ru-Qing; Zeng, Xiao-Wen; Zeeshan, Mohammed; Guo, Yuming; Yu, Yunjiang et al.. JAMA network open 3 9: e2017507. 2020 -
Cryopreservation Affected the Levels of Immune Responses of PBMCs and Antigen-Presenting Cells
Martikainen, Maria-Viola; Roponen, Marjut. Toxicology in vitro 67: 104918. 2020 -
Glial smog: Interplay between air pollution and astrocyte-microglia interactions
Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. Neurochemistry international 136: 104715. 2020 -
Greenness surrounding schools is associated with lower risk of asthma in schoolchildren.
Zeng, Xiao-Wen; Lowe, Adrian J; Lodge, Caroline J; Heinrich, Joachim; Roponen, Marjut; Jalava, Pasi; Guo, Yuming; Hu, Li-Wen; Yang, Bo-Yi; Dharmage, Shyamali C; Dong, Guang-Hui. Environment international 143: 105967. 2020 -
Human Airway Construct Model is Suitable for Studying Transcriptome Changes Associated with Indoor Air Particulate Matter Toxicity
Nordberg, ME; Täubel, M; Jalava, PI; BéruBé, K; Tervahauta, A; Hyvärinen, A; Huttunen, K. Indoor air 30 3: 433-444. 2020 -
Inflammatory responses of urban air PM modulated by chemical composition and different air quality situations in Nanjing, China
Rönkkö, Teemu J; Hirvonen, Maija-Riitta; Happo, Mikko S; Ihantola, Tuukka; Hakkarainen, Henri; Martikainen, Maria-Viola; Gu, Cheng; Wang, Qin'geng; Jokiniemi, Jorma; Komppula, Mika; Jalava, Pasi I. Environmental research 2021; 192: 110382. 2020 -
Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke
Ihantola, Tuukka; Di Bucchianico, Sebastiano; Happo, Mikko; Ihalainen, Mika; Uski, Oskari; Bauer, Stefanie; Kuuspalo, Kari; Sippula, Olli; Tissari, Jarkko; Oeder, Sebastian; Hartikainen, Anni; Rönkkö, Teemu J; Martikainen, Maria-Viola; Huttunen, Kati; Vartiainen, Petra; Suhonen, Heikki; Kortelainen, Miika; Lamberg, Heikki; Leskinen, Ari; Sklorz, Martin et al [incl. Yli-Pirilä, Pasi; Hirvonen, Maij. Particle and fibre toxicology 17 1: 27. 2020 -
Is PM 1 similar to PM 2.5? A new insight into the association of PM 1 and PM 2.5 with children's lung function
Yang, Mo; Guo, Yu-Ming; Bloom, Michael S; Dharmagee, Shyamali C; Morawska, Lidia; Heinrich, Joachim; Jalaludin, Bin; Markevychd, Iana; Knibbsf, Luke D; Lin, Shao; Hung Lan, Steve; Jalava, Pasi; Komppula, Mika; Roponen, Marjut; Hirvonen, Maija-Riitta; Guan, Qi-Hua; Liang, Zi-Mian; Yu, Hong-Yao; Hu, Li-Wen; Yang, Bo-Yi; et al.. Environment international 145: 106092. 2020 -
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Depner, Martin; Taft, Diana Hazard; Kirjavainen, Pirkka V; Kalanetra, Karen M; Karvonen, Anne M; Peschel, Stefanie; Schmausser-Hechfellner, Elisabeth; Roduit, Caroline; Frei, Remo; Lauener, Roger; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Riedler, Josef; Roponen, Marjut; Kabesch, Michael; Renz, Harald; Pekkanen, Juha; Farquharson, Freda M; Louis, Petra; Mills, David A. et al.. Nature medicine 26: 1766-1775. 2020 -
Modification of caesarean section on the associations between air pollution and childhood asthma in seven Chinese cities
Yu, Hongyao; Guo, Yuming; Zeng, Xiaoyun; Gao, Meng; Yang, Bo-Yi; Hu, Li-Wen; Yu, Yunjiang; Dong, Guang-Hui; Zhou, Yang; Qian, Zhengmin; Sun, Jia; McMillin, Stephen Edward; Bloom, Michael S; Heinrich, Joachim; Markevych, Iana; Morawska, Lidia; Dharmage, Shyamali C; Jalaludin, Bin; Knibbs, Luke; Lin, Shao; et al. [incl. Jalava, Pasi; Roponen, Marjut; Leskinen, Ari]. Environmental pollution 267: 115443. 2020 -
Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration
Kanninen, KM; Lampinen, R; Rantanen, LM; Odendaal, L; Jalava, P; Chew, S; White, AR. Neurochemistry international 136: 104729. 2020 -
The role of influenza vaccination in mitigating the adverse impact of ambient air pollution on lung function in children: new insights from the Seven Northeastern Cities Study in China
Liu, K; Yang, B-Y; Guo, Y; Bloom, MS; Dharmage, SC; Knibbs, LD; Heinrich, J; Leskinen, A; Lin, S; Morawska, L; Jalaludin, B; Markevych, I; Jalava, P; Komppula, M; Yu, Y; Gao, M; Zhou, Y; Yu, H-Y; Hu, L-W; Zeng, X-W et al.. Environmental research 187: 109624. 2020 -
Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy
Happonen, Emilia; Tamarov, Konstantin; Martikainen, Maria-Viola; Ketola, Kirsi; Roponen, Marjut; Lehto, Vesa-Pekka; Xu, Wujun. International journal of pharmaceutics 587: 119657. 2020 -
Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions
Hakkarainen, Henri; Aakko-Saksa, Päivi; Sainio, Maija; Ihantola, Tuukka; Rönkkö, Teemu J; Koponen, Päivi; Rönkkö, Topi; Jalava, Pasi I. Particle and fibre toxicology 17 1: 17. 2020 -
Urban air PM modifies differently immune defense responses against bacterial and viral infections in vitro
Shahbaz, Muhammad Ali; Martikainen, Maria-Viola; Rönkkö, Teemu J; Komppula, Mika; Jalava, Pasi I; Roponen, Marjut. Environmental research 192: 110244. 2020 -
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells
Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. Particle and fibre toxicology 17 1: 18. 2020 -
Voiko sisäilman haitallisuutta arvioida toksisuustesteillä?
Mahiout, Selma; Korkalainen, Merja; Wallenius, Kaisa; Viluksela, Matti; Santonen, Tiina; Huttunen, Kati. Ympäristö ja terveys 51 1: 14-16. 2020 -
Adaptation of Black Carbon Footprint Concept Would Accelerate Mitigation of Global Warming
Timonen, Hilkka; Karjalainen, Panu; Aalto, Pami; Saarikoski, Sanna; Mylläri, Fanni; Karvosenoja, Niko; Jalava, Pasi; Asmi, Eija; Aakko-Saksa, Päivi; Saukkonen, Natalia; Laine, Teemu; Saarnio, Karri; Niemelä, Niko; Enroth, Joonas; Väkevä, Minna; Oyola, Pedro; Pagels, Joakim; Ntziachristos, Leonidas; Cordero, Raul; Kuittinen, Niina; et al.. Environmental science and technology 53 21: 12153-12155. 2019 -
Ambient Airborne Particulates of Diameter less than or equal to 1 micrometre, a Leading Contributor to the Association Between Ambient Airborne Particulates of Diameter less than or equal to 2.5 micrometres and Children's Blood Pressure
Wu, QZ; Li, S; Yang, BY; Bloom, M; Shi, Z; Knibbs, L; Dharmage, S; Leskinen, A; Jalaludin, B; Jalava, P; Roponen, M; Lin, S; Chen, G; Guo, Y; Xu, SL; Yu, HY; Zeeshan, M; Hu, LW; Yu, Y; Zeng, XW; et al.. Hypertension 2020; 75 2: 347-355. 2019 -
Association Between Greenness Surrounding Schools and Kindergartens and Attention-Deficit/Hyperactivity Disorder in Children in China
Yang, BY; Zeng, XW; Markevych, I; Bloom, MS; Heinrich, J; Knibbs, LD; Dharmage, SC; Lin, S; Jalava, P; Guo, Y; Jalaludin, B; Morawska, L; Zhou, Y; Hu, LW; Yu, HY; Yu, Y; Dong, GH. JAMA Network Open 2 12: e1917862. 2019 -
Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases
Metzler, S; Frei, R; Schmaußer-Hechfellner, E; von Mutius, E; Pekkanen, J; Karvonen, AM; Kirjavainen, PV; Dalphin, JC; Divaret-Chauveau, A; Riedler, J; Lauener, R; Roduit, C; PASTURE/EFRAIM study group (incl. Roponen, Marjut). Pediatric allergy and immunology 30 4: 423-433. 2019 -
Association between community greenness and obesity in urban-dwelling Chinese adults
Huang, WZ; Yang, BY; Yu, HY; Bloom, MS; Markevych, I; Heinrich, J; Knibbs, LD; Leskinen, A; Dharmage, SC; Jalaludin, B; Morawska, L; Jalava, P; Guo, Y; Lin, S; Zhou, Y; Liu, RQ; Feng, D; Hu, LW; Zeng, XW; Hu, Q; et al.. Science of the total environment 2020; 702: 135040. 2019 -
Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children
Zhang, C; Guo, Y; Xiao, X; Bloom, MS; Qian, Z; Rolling, CA; Xian, H; Lin, S; Li, S; Chen, G; Jalava, P; Roponen, M; Hirvonen, MR; Komppula, M; Leskinen, A; Yim, SHL; Chen, DH; Ma, H; Zeng, XW; Hu, LW; et al.. JAMA network open 2 5: e194186. 2019 -
Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China
Liu, Kangkang; Li, Shanshan; Qian, Zhengmin (Min); Dharmage, Shyamali C; Bloom, Michael S; Heinrich, Joachim; Jalaludin, Bin; Markevych, Iana; Morawska, Lidia; Knibbs, Luke D; Hinyard, Leslie; Xian, Hong; Liu, Shan; Lin, Shao; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Roponen, Marjut; Hu, Li-Wen; Zeng, Xiao-Wen; et al.. Environmental pollution 2020; 256: 113434. 2019 -
Community greenness, blood pressure, and hypertension in urban dwellers: The 33 Communities Chinese Health Study
Yang, BY; Markevych, I; Bloom, MS; Heinrich, J; Guo, Y; Morawska, L; Dharmage, SC; Knibbs, LD; Jalaludin, B; Jalava, P; Zeng, XW; Hu, LW; Liu, KK; Dong, GH. Environment international 126: 727-734. 2019 -
Emissions from a fast-pyrolysis bio-oil fired boiler: Comparison of health-related characteristics of emissions from bio-oil, fossil oil and wood
Sippula, O; Huttunen, K; Hokkinen, J; Kärki, S; Suhonen, H; Kajolinna, T; Kortelainen, M; Karhunen, T; Jalava, P; Uski, O; Yli-Pirilä, P; Hirvonen, MR; Jokiniemi, J. Environmental pollution 248: 888-897. 2019 -
Farm-like indoor microbiota in non-farm homes protects children from asthma development
Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. Nature medicine 25: 1089-1095. 2019 -
Greenness around schools associated with lower risk of hypertension among children: Findings from the Seven Northeastern Cities Study in China
Xiao, Xiang; Yang, Bo-Yi; Markevych, Iana; Bloom, Michael S; Dharmage, Shyamali C; Jalaludin, Bin; Knibbs, Luke D; Heinrich, Joachim; Morawska, Lidia; Lin, Shao; Roponen, Marjut; Guo, Yuming; Hung Lam Yim, Steve; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Yu, Hong-Yao; Zeeshan, Mohammed; Zeng, Xiao-Wen; Dong, Guang-Hui. Environmental pollution 2020; 256: 113422. 2019 -
Keuhkokudoksesta eristetyn RNA:n toksikologinen transkriptomi sisäilmasta kerättyjen hiukkasten terveysvaikutusten tutkimuksessa
Nordberg, Maria-Elisa; Täubel, Martin; Hyvärinen, Anne; Huttunen, Kati / Sisäilmastoseminaari 2019. 2019. 2019 -
Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin
Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. Duodecim 135 13: 1309. 2019 -
Miksi sisäilman haitallisuutta ei voi arvioida toksisuustesteillä?
Mahiout, Selma; Korkalainen, Merja; Wallenius, Kaisa; Viluksela, Matti; Santonen, Tiina; Huttunen, Kati. Duodecim 135 8: 735-743. 2019 -
Oxidative Capacity and Haemolytic Activity of Settled Dust from Moisture-Damaged Schools
Huttunen, K; Wlodarczyk, AJ; Tirkkonen, J; Mikkonen, S; Täubel, M; Krop, E; Jacobs, J; Pekkanen, J; Heederik, D; Zock, JP; Hyvärinen, A; Hirvonen, MR; Adams, R; Jones, T; Zimmermann, R; BéruBé, K. Indoor air 29 2: 299-307. 2019 -
Oxidative stress induced by ultrafine carbon black particles can elicit apoptosis in vivo and vitro
Li, Y; Yang, M; Meng, T; Niu, Y; Dai, Y; Zhang, L; Zheng, X; Jalava, P; Dong, G; Gao, W; Zheng, Y. Science of the total environment 2020; 709: 135802. 2019 -
Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes
Brick, Tabea; Hose, Alexander; Wawretzka, Katharina; von Mutius, Erika; Roduit, Caroline; Lauener, Roger; Riedler, Josef; Karvonen, Anne M; Pekkanen, Juha; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Ege, Markus J; PASTURE study group (incl. Roponen, Marjut; Hirvonen, Maija-Riitta; Kirjavainen, Pirkka Viljami). Pediatric allergy and immunology 30 8: 795-802. 2019 -
Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study
Zeng, XW; Bloom, MS; Dharmage, SC; Lodge, CJ; Chen, D; Li, S; Guo, Y; Roponen, M; Jalava, P; Hirvonen, MR; Ma, H; Hao, YT; Chen, W; Yang, M; Chu, C; Li, QQ; Hu, LW; Liu, KK; Yang, BY; Liu, S; et al. Science of the total environment 663: 60-67. 2019 -
Residential greenness and blood lipids in urban-dwelling adults: The 33 Communities Chinese Health Study
Yang, BY; Markevych, I; Heinrich, J; Bloom, MS; Qian, Z; Geiger, SD; Vaughn, M; Liu, S; Guo, Y; Dharmage, SC; Jalaludin, B; Knibbs, LD; Chen, D; Jalava, P; Lin, S; Hung-Lam Yim, S; Liu, KK; Zeng, XW; Hu, LW; Dong, GH. Environmental pollution 250: 14-22. 2019 -
TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection
Krusche, Johanna; Twardziok, Monika; Rehbach, Katharina; Böck, Andreas; Tsang, Miranda S; Schröder, Paul C; Kumbrink, Jörg; Kirchner, Thomas; Xing, Yuhan; Riedler, Josef; Dalphin, Jean-Charles; Pekkanen, Juha; Lauener, Roger; Roponen, Marjut; Li, Jing; Wong, Chun K; Wong, Gary W K; Schaub, Bianca; Ege, Markus; Depner, Martin; et al.. Journal of allergy and clinical immunology 144 6: 1684-1696.e12. 2019 -
A panel study of airborne particulate matter concentration and impaired cardiopulmonary function in young adults by two different exposure measurement
Hu, Li-Wen; Qian, Zhengmin (Min); Bloom, Michael S; Nelson, Erik J; Liu, Echu; Han, Bin; Zhang, Nan; Liu, Yimin; Ma, Huimin; Chen, Duo-Hong; Yang, Bo-Yi; Zeng, Xiao-Wen; Chen, Wen; Komppula, Mika; Leskinen, Ari; Hirvonen, Maija-Riitta; Roponen, Marjut; Jalava, Pasi; Bai, Zhipeng; Dong, Guang-Hui. Atmospheric Environment 180: 103-109. 2018 -
Design and validation of an air-liquid interface (ALI) exposure device based on thermophoresis
Ihalainen, Mika; Jalava, Pasi; Ihantola, Tuukka; Kasurinen, Stefanie; Uski, Oskari; Sippula, Olli; Hartikainen, Anni; Tissari, Jarkko; Kuuspalo, Kari; Lähde, Anna; Hirvonen, Maija-Riitta; Jokiniemi, Jorma. Aerosol science and technology 2019; 53 2: 133-145. 2018 -
Differences between co-cultures and monocultures in testing the toxicity of particulate matter derived from log wood and pellet combustion
Kasurinen, S; Happo, MS; Rönkkö, TJ; Orasche, J; Jokiniemi, J; Kortelainen, M; Tissari, J; Zimmermann, R; Hirvonen, MR; Jalava, PI. PLOS ONE 13 2: e0192453. 2018 -
Early age exposure to moisture damage and systemic inflammation at the age of 6 years
Karvonen, AM; Tischer, C; Kirjavainen, PV; Roponen, M; Hyvärinen, A; Illi, S; Mustonen, K; Pfefferle, PI; Renz, H; Remes, S; Schaub, B; von Mutius, E; Pekkanen, J. INDOOR AIR 28 3: 450-458. 2018 -
Emissions and atmospheric processes influence the chemical composition and toxicological properties of urban air particulate matter in Nanjing, China
Rönkkö, TJ; Jalava, PI; Happo, MS; Kasurinen, S; Sippula, O; Leskinen, A; Koponen, H; Kuuspalo, K; Ruusunen, J; Väisänen, O; Hao, L; Ruuskanen, A; Orasche, J; Fang, D; Zhang, L; Lehtinen, KEJ; Zhao, Y; Gu, C; Wang, Q; Jokiniemi, J; et al.. SCIENCE OF THE TOTAL ENVIRONMENT 639: 1290-1310. 2018 -
Emissions from a modern log wood masonry heater and wood pellet boiler: Composition and biological impact on air-liquid interface exposed human lung cancer cells
Kanashova, Tamara; Sippula, Olli; Oeder, Sebastian; Streibel, Thorsten; Passig, Johannes; Czech, Hendryk; Kaoma, Tony; Sapcariu, Sean C; Dilger, Marco; Paur, Hanns-Rudolf; Schlager, Christoph; Mülhopt, Sonja; Weiss, Carsten; Schmidt-Weber, Carsten; Traidl-Hoffmann, Claudia; Michalke, Bernhard; Krebs, Tobias; Karg, Erwin; Jakobi, Gert; Scholtes, Sorana; et al [Incl Jalava, Pasi; Jokiniemi, Jorma; K. Journal of Molecular and Clinical Medicine 1 1: 23-35. 2018 -
High levels of Butyrate and Propionate in early life are associated with protection against atopy
Roduit, C; Frei, R; Ferstl, R; Loeliger, S; Westermann, P; Rhyner, C; Schiavi, E; Barcik, W; Rodriguez-Perez, N; Wawrzyniak, M; Chassard, C; Lacroix, C; Schmausser-Hechfellner, E; Depner, M; von Mutius, E; Braun-Fahrländer, C; Karvonen, A; Kirjavainen, P; Pekkanen, J; Dalphin, JC; et al. Allergy 2019; 74 4: 799-809. 2018 -
In vitro -solumallit sisäilmasta kerättyjen hiukkasten terveysvaikutusten tutkimuksessa
Nordberg, Maria-Elisa; Gajšt, Tamara; Täubel, Martin; Jalava, Pasi; Jalkanen, Kaisa; Hyvärinen, Anne; Huttunen, Kati / Sisäilmastoseminaari 2018. 2018. 2018 -
Indoor air pollution
Huttunen, Kati. In: Capello, Fabio; Gaddi, Antonio Vittorino (ed.) Clinical Handbook of Air Pollution-Related Diseases. Springer. s. 107-114. 2018 -
Integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high-risk environments
Martikainen, MV; Rönkkö, TJ; Schaub, B; Täubel, M; Gu, C; Wong, GW; Li, J; Pekkanen, J; Komppula, M; Hirvonen, MR; Jalava, PI; Roponen, M. PEDIATRIC ALLERGY AND IMMUNOLOGY 29 8: 815-822. 2018 -
Is smaller worse? New insights about associations of PM1 and respiratory health in children and adolescents
Yang, M; Chu, C; Bloom, MS; Li, S; Chen, G; Heinrich, J; Markevych, I; Knibbs, LD; Bowatte, G; Dharmage, SC; Komppula, M; Leskinen, A; Hirvonen, MR; Roponen, M; Jalava, P; Wang, SQ; Lin, S; Zeng, XW; Hu, LW; Liu, KK; et al.. Environment international 120: 516-524. 2018 -
PM2.5 concentration and composition in the urban air of Nanjing, China: Effects of emission control measures applied during the 2014 Youth Olympic Games
Miettinen, M; Leskinen, A; Abbaszade, G; Orasche, J; Sainio, M; Mikkonen, S; Koponen, H; Rönkkö, T; Ruusunen, J; Kuuspalo, K; Tiitta, P; Jalava, P; Hao, L; Fang, D; Wang, Q; Gu, C; Zhao, Y; Michalke, B; Schnelle-Kreis, J; Lehtinen, KE; et al.. SCIENCE OF THE TOTAL ENVIRONMENT 2019; 652: 1-18. 2018 -
Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants
Gorlanova, O; Illi, S; Toncheva, AA; Usemann, J; Latzin, P; Kabesch, M; Dalphin, JC; Lauener, R; Pekkanen, JR; Von Mutius, E; Riedler, J; Kuehni, CE; Röösli, M; Frey, U; et al.; BILD and PASTURE study groups (incl. Roponen, M). ALLERGY 73 12: 2388-2392. 2018 -
The development of immune responses and allergic diseases : the role of prenatal and early life exposures
Martikainen, Maria-Viola. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences 322. 2018 -
Wide band frequency measurements of fungal species uisng laser patterned finger electrodes on LTCC
Sobocinski, J; Mensah-Attipoe, S; Myllymaki, N; Halonen, M; Tuhkala, J; Putaala; Lloyd-Spetz, A; Pasanen, P. Progress In Electromagnetics Research Letters 73: 121-125. 2018 -
Analysis Approaches for Fungi in Indoor Environmental Assessments
Mensah-Attipoe Jacob, Taubel Martin. In: Viegas Carla, Viegas Susana, Gomes Anita, Täubel Martin, Sabino Raquel (ed.) Exposure to Microbiological Agents in Indoor and Occupational Environments. Springer. s. 109-127. 2017 -
Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children
Twardziok M, Schröder PC, Krusche J, Casaca VI, Illi S, Böck A, Loss GJ, Kabesch M, Toncheva A, Roduit C, Depner M, Genuneit J, Renz H, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC et al., the PASTURE Study Group. Clinical Immunology 183: 285-292. 2017 -
Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis
Frei Remo, Ferstl Ruth, Roduit Caroline, Ziegler Mario, Schiavi Elisa, Barcik Weronika, Rodriguez-Perez Noelia, Wirz Oliver F, Wawrzyniak Marcin, Pugin Benoit, Nehrbass Dirk, Jutel Marek, Smolinska Sylwia, Konieczna Patrycja, Bieli Christian, Loeliger Susanne, Waser Marco, Pershagen Göran, Riedler Josef, Depner Martin et al. (incl. Roponen Marjut, Hirvonen Marja-Riitta, Pekkanen Juha). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2018; 141 1: 382-390.e7. 2017 -
Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants
Delgado-Eckert E, Fuchs O, Kumar N, Pekkanen J, Dalphin JC, Riedler J, Lauener R, Kabesch M, Kupczyk M, Dahlen SE, Mutius EV, Frey U et al., PASTURE Study group, BIOAIR Study group. THORAX 2018; 73 2: 107-115. 2017 -
In vitro toxicological effects of zinc containing nanoparticles with different physico-chemical properties
Uski O, Torvela T, Sippula O, Karhunen T, Koponen H, Peräniemi S, Jalava P, Happo M, Jokiniemi J, Hirvonen M-R, Lähde A. TOXICOLOGY IN VITRO 42: 105-113. 2017 -
Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children
Zhou Y, Hu LW, Qian Z, Geiger SD, Parrish KL, Dharmage SC, Campbell B, Roponen M, Jalava P, Hirvonen MR, Heinrich J, Zeng XW, Yang BY, Qin XD, Lee YLL, Dong GH. Scientific Reports 7: 899. 2017 -
Latent class analysis reveals clinically relevant atopy phenotypes in two birth cohorts
Hose AJ, Depner M, Illi S, Lau S, Keil T, Wahn U, Fuchs O, Pfefferle PI, Schmaußer-Hechfellner E, Genuneit J, Lauener R, Karvonen AM, Roduit C, Dalphin JC, Riedler J, Pekkanen J, von Mutius E, Ege MJ, Bauer CP, Forster J et al., MAS and PASTURE Study Grops. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 139 6: 1935-1945.e12-. 2017 -
Microbial Secondary Metabolites and Knowledge on Inhalation Effects
Huttunen K, Korkalainen M. In: Viegas Carla, Viegas Susana, Gomes Anita, Täubel Martin, Sabino Raquel (ed.) Exposure to Microbiological Agents in Indoor and Occupational Environments. Springer. s. 213-234. 2017 -
Mikrobitoksiinien hengitystievaikutukset
Huttunen K, Korkalainen M, Täubel M, Pekkanen J, Hyvärinen A. In: Säteri Jorma, Ahola Mervi (ed.) , Sisäilmastoseminaari 2017: Messukeskus, Helsinki 15.3.2017. Sisäilmayhdistys. SIY Raportti 35. s. 372-378. 2017 -
Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood
Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, Schmausser-Hechfellner E, Pekkanen J, Riedler J, Dalphin J-C, von Mutius E, Lauener RP and the PASTURE study group. JAMA Pediatrics 171 7: 655-662. 2017 -
The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life
Martikainen M-V, Keski-Nisula L, Jakupovic H, Karvonen AM, Pekkanen J, Hirvonen M-R, Roponen M. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (NEW YORK) 77 3: -. 2017 -
Toxicity of airborne dust as an indicator of moisture problems in school buildings
Tirkkonen J, Täubel M, Leppänen H, Peltonen M, Lindsley W, Chen BT, Hyvärinen A, Hirvonen M-R, Huttunen K. Inhalation toxicology 29 2: 75-81. 2017 -
A switch in regulatory T cells through farm-exposure during immune maturation in childhood
Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, Depner M, Frei R, Genuneit J, Pfefferle PI, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Dalphin JC, Pekkanen J, Lauener R, von Mutius E, Schaub B, PASTURE study group (Hyvärinen A, Karvonen AM, Hirvonen MR, Tiittanen P, Remes S, Kaulek V, Dalphin ML, Ege MJ, Loss GJ, Renz H, Doekes G, Kabesch M). ALLERGY [Epub ahead of print 17 Nov 2016]: -. 2016 -
An emerging paradox: Toward a better understanding of the potential benefits and adversity of microbe exposures in the indoor environment
Mensah-Attipoe J, Täubel M, Hernandez M, Pitkäranta M, Reponen T. INDOOR AIR 2017; 27 1: 3 - 5. 2016 -
Associations of Early Life Exposures and Environmental Factors With Asthma Among Children in Rural and Urban Areas of Guangdong, China
Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schröder PC, Roponen M, Schaub B, Wong GW, Li J. CHEST 149 4: 1030-1041. 2016 -
Associations of natural history and environmental factors with asthma among children in rural and urban areas of Guangdong, China
Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schröder PC, Roponen M, Schaub B, Wong GWK, Li J. CHEST 149 4: 1030-1041. 2016 -
Comparison of Methods for assessing temporal variation of growth of fungi on building materials
Mensah-Attipoe Jacob, Reponen Tiina, Veijalainen Anna-Maria, Rintala Helena, Täubel Martin, Rantakokko Panu, Ying Jun, Hyvärinen Anne, Pasanen Pertti. Microbiology 162: 1895-1903. 2016 -
Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy
Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin J-C, Kaulek V, Loss GJ, Lauener R, Hirvonen M-R, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J, the PASTURE study group. PEDIATRIC ALLERGY AND IMMUNOLOGY 2017; 28 1: 53-59. 2016 -
Evaluation of sampling methods for toxicological testing of indoor air particulate matter
Tirkkonen J, Täubel M, Hirvonen MR, Leppänen H, Lindsley WG, Chen BT, Hyvärinen A, Huttunen K. Inhalation toxicology 28 11: 500-507. 2016 -
IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort
Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin J-C, Pekkanen J, von Mutius E et al.. PEDIATRIC ALLERGY AND IMMUNOLOGY 27 7: 687-695. 2016 -
Maatila-altistuminen muokkaa lasten immuunivastetta sääteleviä mekanismeja
Martikainen Maria-Viola, Roponen Marjut. BestPractice Keuhkosairaudet: lääketieteen asiantuntijoiden ammattilehti 12: 22-23. 2016 -
Microbial contamination of building materials: growth and aerosolization
Mensah-Attipoe Jacob. University of Eastern Finland. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences 211. 2016 -
Moisture accumulation in building materials and growth of fungi
Mensah-Attipoe Jacob, Reponen Tiina, Pasanen Pertti. In: Mazela B, Perdoch W, Broda M, Greskowiak W, Jones D. (ed.) , Proceedings of Hygrothermal performance of buildings and their materials. Poznan University of Life Sciences. s. 7-8. 2016 -
Particulate emissions from the combustion of birch, beech, and spruce logs cause different cytotoxic responses in A549 cells
Kasurinen Stefanie, Jalava Pasi I, Happo Mikko S, Sippula Olli, Koponen Hanna, Orasche Jürgen, Zimmermann Ralf, Jokiniemi Jorma, Hirvonen Maija-Riitta. ENVIRONMENTAL TOXICOLOGY [Epub ahead of print 28 Sep 2016]: 1-13. 2016 -
Radiative and climate impacts of a large volcanic eruption during stratospheric sulfur geoengineering
Laakso A, Kokkola H, Partanen A.-I, Niemeier U, Timmreck C, Lehtinen KEJ, Hakkarainen H, Korhonen H. ATMOSPHERIC CHEMISTRY AND PHYSICS 16 1: 305-323. 2016 -
Release and characteristics of fungal fragments in various conditions
Mensah-Attipoe Jacob, Saari Sampo, Veijalainen Anna-Maria, Pasanen Pertti, Keskinen Jorma, Leskinen Jari TT, Reponen Tiina. Science of the total environment 547: 234-243. 2016 -
The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21
Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ, PASTURE study group (Dalphin M-L, Doekes G, Frei R, Hirvonen M-R, Illi S, Kaulek V, Schaub B, Remes S, Renz H, Roponen M, Tiittanen P). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 8: 889-897. 2016 -
Triboelectric charging of fungal spores during resuspension and rebound
Kuuluvainen Heino, Saari Sampo, Mensah-Attipoe Jacob, Arffman Anssi, Pasanen Pertti, Reponen Tiina, Keskinen Jorma. AEROSOL SCIENCE AND TECHNOLOGY 50 2: 187-197. 2016 -
Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity
Muala Ala, Rankin Gregory, Sehlstedt Maria, Unosson Jon, Bosson Jenny A, Behndig Annelie, Pourazar Jamshid, Nyström Robin, Pettersson Esbjörn, Bergvall Christoffer, Westerholm Roger, Jalava Pasi I, Happo Mikko S, Uski Oskari, Hirvonen Maija-Riitta, Kelly Frank J, Mudway Ian S, Blomberg Anders, Boman Christoffer, Sandström Thomas. Particle and Fibre Toxicology 12 33: -. 2015 -
Characterization and testing of a new environmental chamber
Leskinen A, Yli-Pirilä P, Kuuspalo K, Sippula O, Jalava P, Hirvonen M-R, Jokiniemi J, Virtanen A, Komppula M, Lehtinen KEJ. Atmospheric Measurement Techniques 8: 2267-2278. 2015 -
Chemical and microbial components of urban air PM cause seasonal variation of toxicological activity
Jalava Pasi I, Happo Mikko S, Huttunen Kati, Sillanpää Markus, Hillamo Risto, Salonen Raimo O, Hirvonen Maija-Riitta. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 40 2: 375-387. 2015 -
Circulating dendritic cells, farm exposure and asthma at early age
Kääriö Heidi, Nieminen Janne K, Karvonen Anne M, Huttunen Kati, Schröder Paul C, Vaarala Outi, von Mutius Erika, Pfefferle Petra Ina, Schaub Bianca, Pekkanen Juha, Hirvonen Maija-Riitta, Roponen Marjut. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 83 (2016) 1: 18-25. 2015 -
DETERMINATION OF FUNGAL CONTAMINATION USING TOTAL FUNGAL BIOMASS
Mensah-Attipoe Jacob, Pasanen Pertti, Veijalainen Anna-Maria, Taubel Martin, Hyvärinen Anne, Rintala Helena, Reponen Tiina. Loomans M and te Kulve M, (Eds), Healthy Buildings Europe 2015.ISIAQ. 4. 2015 -
Day and night variation in chemical composition and toxicological responses of size segregated urban air PM samples in a high air pollution situation
Jalava PI, Wang Q, Kuuspalo K, Ruusunen J, Hao L, Fang D, Väisänen O, Ruuskanen A, Sippula O, Happo MS, Uski O, Kasurinen S, Torvela T, Koponen H, Lehtinen KEJ, Komppula M, Gub C, Jokiniemi J, Hirvonen M-R. ATMOSPHERIC ENVIRONMENT 120: 427-437. 2015 -
Exposure to a farm environment is associated with Th1 and regulatory cytokines at age 4.5 years
Kääriö H, Huttunen K, Karvonen AM, Schaub B, von Mutius E, Pekkanen J, Hirvonen MR, Roponen M. Clinical & Experimental Allergy 2016; 46 1: 71-77. 2015 -
Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6
Martikainen M-V, Kääriö H, Karvonen A Schröder PC, Renz H, Kaulek V, Dalphin J-C, von Mutius E, Schaub B, Pekkanen J, Hirvonen M-R, Roponen M. ALLERGY 70 10: 1278-1287. 2015 -
High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6
Orivuori L, Mustonen K, de Goffau MC, Hakala S, Paasela M, Roduit C, Dalphin JC, Genuneit J, Lauener R, Riedler J, Weber J, von Mutius E, Pekkanen J, Harmsen HJ, Vaarala O, PASTURE Study Group (Hirvonen MR, Hyvärinen A, Karvonen AM, Remes S, Roponen M, Tiittanen P, Dalphin ML, Kaulek V, Depner M, Ege M, Illi S, Kabesch M, Pfefferle P, Renz H, Schaub B, Doekes G, Braun-Fahrländer C, Frei R, Loss G). CLINICAL AND EXPERIMENTAL ALLERGY 45 5: 928-939. 2015 -
Identification of single microbial particles using electro-dynamic balance assisted laser-induced breakdown and fluorescence spectroscopy
Saari S, Järvinen S, Reponen T, Mensah-Attipoe J, Pasanen P, Toivonen J, Keskinen J. AEROSOL SCIENCE AND TECHNOLOGY 50 2, 2016: 126-132. 2015 -
Inflammatory potential in relation to the microbial content of settled dust samples collected from moisture-damaged and reference schools: results of HITEA study
Huttunen K, Tirkkonen J, Täubel M, Krop E, Mikkonen S, Pekkanen J, Heederik D, Zock J-P, Hyvärinen A, Hirvonen M-R. INDOOR AIR 2016; 26 3: 380-90. 2015 -
Moisture damage in home associates with systemic inflammation in children
Mustonen K, Karvonen AM, Kirjavainen P, Roponen M, Schaub B, Hyvärinen A, Frey U, Renz H, Pfefferle PI, Genuneit J, Vaarala O, Pekkanen J. INDOOR AIR [epub ahead of print 23 May 2015]: -. 2015 -
Toxicological characterization of particulate emissions from straw, mischantus, poplar pellet combustion in residential boilers
Kasurinen Stefanie, Jalava Pasi I, Uski Oskari, Happo Mikko S, Brunner Thomas, Mäki-Paakkanen Jorma, Jokiniemi Jorma, Obernberger Ingwald, Hirvonen Maija-Riitta. AEROSOL SCIENCE AND TECHNOLOGY 2016; 50 1: 41-51. 2015 -
Biological effects of inhalable compounds - improvements of the in vitro testing method
Ritter Detlef, Knebel Jan, Brodbeck Carsten, Jalava Pasi. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 115 1: 157. 2014 -
Building up a co-culture and surfactant model for routine use in ali exposures
Jalava Pasi, Ritter Detlef, Knebel Jan. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 115 1: 156. 2014 -
Characterization and testing of a new environmental chamber designed for emission aging studies
Leskinen A, Yli-Pirilä P, Kuuspalo K, Sippula O, Jalava P, Hirvonen M-R, Jokiniemi J, Virtanen A, Komppula M, Lehtinen KEJ. Atmospheric Measurement Techniques Discussion 7 6: 5921-5951. 2014 -
Characterization of Fungal Fragments
Mensah-Attipoe Jacob, Saari Sampo, Keskinen Jorma, Salmela Anniina, Veijalainen Anna-Maria, Pasanen Pertti, Reponen Tiina. -, 2014 AAAR Annual Conference Abstracts.American Association for Aerosol Research (AAAR). AAAR Annual Conference Abstracts 2014. 11BA.4. 2014 -
Characterization of Fungal Spores and Fragments Released in Various Conditions
Mensah-Attipoe Jacob, Saari Sampo, Keskinen Jorma, Salmela Anniina, Veijalainen Anna-Maria, Pasanen Pertti, Reponen Tiina. -, Abstract Book of the 24th Annual Meeting of the International Society of Exposure Science (ISES).ISES. Abstract Book of the Annual Meeting of the International Society of Exposure Science 2014. 10. 2014 -
Charge of airborne fungal particles
Reponen Tiina, Saari Sampo, Mensah-Attipoe Jacob, Ukkonen Ari, Veijalainen Anna-Maria, Pasanen Pertti. Yuguo Li, Indoor Air 2014. 1-3. 2014 -
Clinical and Epidemiologic Phenotypes of Childhood Asthma
Depner Martin, Fuchs Oliver, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Kaulek Vincent, Roduit Caroline, Weber Juliane, Schaub Bianca, Lauener Roger, Kabesch Michael, Pfefferle Petra Ina, Frey Urs, Pekkanen Juha, Dalphin Jean-Charles, Riedler Joseph, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J and the PASTURE Study Group. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 189 2: 129-138. 2014 -
Comparison of methods for assessing growth of fungi on building materials
Mensah-Attipoe Jacob, Reponen Tiina, Veijalainen Anna-Maria, Rintala Helena, Täubel Martin, Hyvärinen Anne, Salmela Anniina, Pasanen Pertti. Yuguo Li, Indoor Air 2014. 1-3. 2014 -
Consumption of unprocessed cow's milk protects infants from common respiratory infections
Loss Georg, Depner Martin, Ulfman Laurien H, van Neerven RJ Joost, Hose Alexander J, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Kaulek Vincent, Roduit Caroline, Weber Juliane, Lauener Roger, Pfefferle Petra Ina, Pekkanen Juha, Vaarala Outi, Dalphin Jean-Charles, Riedler Josef, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J. and the PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 135 1: 56-62.E2. 2014 -
Determinants of interleukin-12 in stable ischaemic heart disease
Salonen Iiris, Huttunen Kati, Hirvonen Maija-Riitta, Dufva Juhani, Groundstroem Kaj, Dufva Hilkka, Salonen Raimo O. Cardiovascular Endocrinology 3 4: 123-128. 2014 -
Determinants, reproducibility, and seasonal variation of bacterial cell wall components and viable counts in house dust
Leppänen HK, Täubel M, Roponen M, Vepsäläinen A, Rantakokko P, Pekkanen J, Nevalainen A, von Mutius E, Hyvärinen A.. INDOOR AIR 2015; 25 3: 260-272. 2014 -
Different toxic mechanisms are activated by emission PM depending on combustion efficiency
Uski O, Jalava PI, Happo MS, Leskinen J, Sippula O, Tissari J, Mäki-Paakkanen J, Jokiniemi J, Hirvonen M-R. ATMOSPHERIC ENVIRONMENT 89: 623-632. 2014 -
Effect of fuel zinc content on toxicological responses of particulate matter from pellet combustion in vitro
Uski O, Jalava PI, Happo MS, Torvela T, Leskinen J, Mäki-Paakkanen J, Tissari J, Sippula O, Lamberg H, Jokiniemi J, Hirvonen M-R. SCIENCE OF THE TOTAL ENVIRONMENT 511: 331-340. 2014 -
Effects of different factors on the fluorescence properties of fungas spores
S. Saari; J. Mensah-Attipoe; T. Reponen; A. Salmela; A-M. Veijalainen; P. Pasanen; J. Keskinen. Brucklacher, Beate; Mann, Sibylle; Metzig Gunthart, Conference on Aerosol Technology 2014.Gesellschaft fuer Aerosolforschung e.V.. Aerosol Technology 2014. 1-3. 2014 -
Effects of fungal species, cultivation time, growth substrate, and air exposure velocity on the fluorescence properties of airborne fungal spores
Saari S, Mensah-Attipoe J, Reponen T, Veijalainen A-M, Salmela A, Pasanen P, Keskinen J. INDOOR AIR Epub ahead of print: x-x. 2014 -
Effects of various factors on fluorescence properties of fungal spores
Saari Sampo, Mensah-Attipoe Jacob, Veijalainen Anna-Maria, Salmela Anniina, Pasanen Pertti, Reponen Tiina, Keskinen Jorma,. Szponar Bogumila, Proceedings of 3rd Workplace and indoor aerosols conference.Institute of Innunology and experimental therapy, polish academy of sciences. Proceedings of 3rd Workplace and indoor aerosols conference -. 1. 2014 -
Electrical charge of fungal spores aerosolized from different types if surfaces
Saari Sampo, Mensah-Attipoe Jacob, Ukkonen Ari, Veijalainen Anna-Maria, Pasanen Pertti, Reponen Tiina, Keskinen Jorma,. -, NOSA 2014.Nordic Society for Aerosol Research. Nosa Aerosol Symposium 2014. Book of Abstracts -. P61. 2014 -
Fine particle emissions in three different combustion conditions of a woodchip-fired appliance: Particulate physico-chemical properties and induced cell death
Leskinen J, Tissari J, Uski O, Virén A, Torvela T, Kaivosoja T, Lamberg H, Nuutinen I, Kettunen T, Joutsensaari J, Jalava PI, Sippula O, Hirvonen M-R, Jokiniemi J. ATMOSPHERIC ENVIRONMENT 86C: 129-139. 2014 -
Fluorescence based real-time measurements of fungal spores and fragments
Saari Sampo, Mensah-Attipoe Jacob, Veijalainen Anna-Maria, Hellsten Anniina, Pasanen Pertti, Reponen Tiina, Keskinen Jorma. Sanna Pynnönen, Tuula Tuhkanen, Proceedings of Finnish conference of environmental sciences. 41-43. 2014 -
Immunoglobulin A and immunoglobulin G antibodies against ß-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O, PASTURE Study Group (Hirvonen MR, Hyvärinen A, Karvonen AM, Remes S, Roponen M, Tiittanen P, Dalphin ML, Kaulek V, Büchele G, Depner M, Ege M, Kabesch M, Pfefferle P, Renz H, Schaub B, Doekes G, Frei R). PEDIATRIC ALLERGY AND IMMUNOLOGY 25 4: 329-337. 2014 -
Increased food diversity in the first year of life is inversely associated with allergic diseases
Roduit Caroline, Frei Remo, Depner Martin, Schaub Bianca, Loss Georg, Genuneit Jon, Pfefferle Petra, Hyvärinen Anne, Karvonen Anne M, Riedler Josef, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Braun-Fahrländer Charlotte, Lauener Roger; PASTURE study group (Hirvonen Maija-Riitta, Remes Sami, Roponen Marjut, Tiittanen Petri, Dalphin Marie-Laure, Kaulek Vincent, Buchele Gisela, Ege Markus,. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 133 4: 1056-1064. 2014 -
Influence of ozone initiated processing on the toxicity of aerosol particles from small scale wood combustion
Nordin Erik Z, Uski Oskari, Nyström Robin, Jalava Pasi, Eriksson Axel C, Genberg, Johan, Roldin Pontus, Bergvall Christoffer, Westerholm Roger, Jokiniemi Jorma, Pagels Joakim H, Boman Christoffer, Hirvonen Maija-Riitta. ATMOSPHERIC ENVIRONMENT 102: 282-289. 2014 -
Novel applications for single particle levitation in electrodynamic balance chamber
Saari Sampo, Järvinen S, Mensah-Attipoe Jacob, Veijalainen Anna-Maria, Pasanen Pertti, Reponen Tiina, Toivonen J, Keskinen Jorma,. Brucklacher Beate, Mann Sibylle, Metzig Gunthart, Conference on Aerosol Technology 2014.Gesellschaft fur Aerosol Forschnung e.V.. Aerosol Technology 2014 -. 1-3. 2014 -
Reference particles for toxicological studies of wood combustion: formation, characteristics, and toxicity compared to those of real wood combustion particulate mass
Torvela Tiina, Uski Oskari, Karhunen Tommi, Lähde Anna, Sippula Olli, Tissari Jarkko, Jalava Pasi, Hirvonen Maija-Riitta, Jokiniemi Jorma,. CHEMICAL RESEARCH IN TOXICOLOGY 27: 1516-1527. 2014 -
Release of fungal spores and fragments in various conditions
Mensah-Attipoe Jacob, Saari Sampo, Keskinen J, Veijalainen Anna-Maria, Pasanen P, Reponen Tiina. -, NOSA 2014.Nordic Society for Aerosol Research. Nosa Aerosol Symposium 2014. Book of Abstracts -. O25. 2014 -
Role of microbial and chemical composition in toxicological properties of indoor and outdoor air particulate matter
Happo Mikko S, Sippula Olli, Jalava Pasi I, Rintala Helena, Leskinen Ari, Komppula Mika, Kuuspalo Kari, Mikkonen Santtu, Lehtinen Kari, Jokiniemi Jorma, Hirvonen Marja-Riitta. Particle and Fibre Toxicology 11: 1-18. 2014 -
Source-specific fine particulate air pollution and systemic inflammation in ischaemic heart disease patients
Siponen Taina, Yli-Tuomi Tarja, Aurela Minna, Dufva Hilkka, Hillamo Risto, Hirvonen Maija-Riitta, Huttunen Kati, Pekkanen Juha, Pennanen Arto, Salonen Iiris, Tiittanen Pekka, Salonen Raimo O, Lanki Timo. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 2015; 72 4: 277-283. 2014 -
Susceptibility of green and conventional building materials to microbial growth
Mensah-Attipoe Jacob, Reponen Tiina, Salmela Anniina, Veijalainen Anna-Maria, Pasanen Pertti. INDOOR AIR 25 3: 273-284. 2014 -
The effect of assay type and sample matrix on detected cytokine concentrations in human blood serum and nasal lavage fluid
Huttunen Kati, Tiihonen Kati, Roponen Marjut, Heederik Dick, Zock Jan-Paul, Täubel Martin, Hyvärinen Anne, Hirvonen Maija-Riitta. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 96 -: 151-155. 2014 -
Toxicological effects of particulate emissions - A comparison of oil and wood fuels in small- and medium-scale heating systems
Kasurinen Stefanie, Jalava Pasi I., Tapanainen Maija, Uski Oskari, Happo Mikko S., Maki-Paakkanen Jorma, Lamberg Heikki, Koponen Hanna, Nuutinen Ilpo, Kortelainen Miika, Jokiniemi Jorma, Hirvonen Maija-Riitta. ATMOSPHERIC ENVIRONMENT 2015; 103: 321-330. 2014 -
Atopic sensitization in the first year of life
Depner M, Ege MJ, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Kaulek V, Krauss-Etschmann S, Riedler J, Braun-Fahrländer C, Roduit C, Lauener R, Pfefferle PI, Weber J, von Mutius E; PASTURE Study Group.. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 131 3: 781-788. 2013 -
Characterization of Chemical and Microbial Species from Size-Segregated Indoor and Outdoor Particulate Samples
Sippula O, Rintala H, Happo M, Jalava P, Kuuspalo K, Virén A, Leskinen A, Markkanen A, Komppula M, Markkanen P, Lehtinen K, Jokiniemi J, Hirvonen M-R. Aerosol and Air Quality Research 13: 1212-1230. 2013 -
Comparison of emissions and toxicological properties of fine particles from wood and oil boilers in small (20-25 kW) and medium (5-10 MW) scale
Kaivosoja Terhi, Jalava Pasi, Lamberg Heikki, Virén Annika, Tapanainen Maija, Torvela Tiina, Tapper Unto, Sippula Olli, Tissari Jarkko, Hillamo Raimo, Hirvonen Maija-Riitta, Jokiniemi Jorma. ATMOSPHERIC ENVIRONMENT 77: 193-201. 2013 -
Dampness and mould in schools and respiratory symptoms in children: the HITEA study
Borràs-Santos Alicia, Jacobs José H, Täubel Martin, Haverinen-Shaughnessy Ulla, Krop Esmeralda JM, Huttunen Kati, Hirvonen Maija-Riitta, Pekkanen Juha, Heederik Dick JJ, Zock Jan-Paul, Hyvärinen Anne. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 70 10: 681-687. 2013 -
Determinants, reproducibility, and seasonal variation of ergosterol levels in house dust
Leppänen HK, Nevalainen A, Vepsäläinen A, Roponen M, Täubel M, Laine O, Rantakokko P, von Mutius E, Pekkanen J, Hyvärinen A. Indoor air 24 3: 248-259. 2013 -
Effect of moisture-damage intervention on the immunotoxic potential and microbial content of airborne particles and on occupants' upper airway inflammatory responses
Roponen M, Meklin T, Rintala H, Hyvärinen A, Hirvonen MR. INDOOR AIR 23 4: 295-302. 2013 -
Evaluating of growth of microbes on green and non-green building materials
Mensah-Attipoe Jacob, Reponen Tiina, Hellsten Anniina, Veijalainen Anna-Maria, Pasanen Pertti. Säteri J, Backman H, Sisäilmastoseminaari 2013. 45-50. 2013 -
Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy
Michel S, Busato F, Genuneit J, Pekkanen J, Dalphin JC, Riedler J, Mazaleyrat N, Weber J, Karvonen AM, Hirvonen MR, Braun-Fahrländer C, Lauener R, von Mutius E, Kabesch M, Tost J; PASTURE study group.. ALLERGY 68 3: 355-364. 2013 -
Hiukkaspäästöjen terveysvaikutukset
Uski Oskari, Jalava Pasi, Happo Mikko, Hirvonen Maija-Riitta. NUOHOOJAT 2: 16-17. 2013 -
Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood
Lluis A, Depner M, Gaugler B, Saas P, Liu L, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton D, Dalphin J-C, Pekkanen J, von Mutius E, Schaub B and the PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY - [Epub ahead of print]: -. 2013 -
Inflammatory response and IgE sensitization at early age
Mustonen K, Orivuori L, Keski-Nisula L, Hyvärinen A, Pfefferle PI, Riedler J, Dalphin JC, Genuneit J, Lauener R, Roduit C, Braun-Fahrländer C, Weber J, Schaub B, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.. PEDIATRIC ALLERGY AND IMMUNOLOGY 24 4: 395-401. 2013 -
Kosteus- ja homevaurioituneista kouluista kerätyn pölynäytteen analysointi: kun toksikologia kohtaa mikrobiologian
Huttunen K, Tirkkonen J, Krop E, Täubel M, Pekkanen J, Hyvärinen A, Heederik D, Zock J-P, Hirvonen M-R.. Sisäilmayhdistys ry, Helsinki, Sisäilmayhdistys raportti.Sisäilmayhdistys ry, Helsinki. Sisäilmayhdistys raportti. ---. 2013 -
Seasonal variation in the toxicological properties of size-segregated indoor and outdoor air particulate matter
Happo MS, Markkanen A, Markkanen P, Jalava P, Kuuspalo K, Leskinen A, Sippula O, Lehtinen K, Jokiniemi J, Hirvonen M-R. TOXICOLOGY IN VITRO 27: 1550-1561. 2013 -
Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: The PASTURE cohort study
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O; ThePASTURE Study Group. CLINICAL AND EXPERIMENTAL ALLERGY Epub: x-x. 2013 -
Toksisuustesti sisäilmanäytteille? TOXTEST tutkimuksen tuloksia
Huttunen K, Alenius H, Hyvärinen A, Lilius E-M, Salkinoja-Salonen M, Lehto M, Leino M, Matikainen S, Täubel M, Järvi K, Nevalainen A, Atosuo J, Andersson M, Mikkola R, Markkanen P, Hirvonen M-R.. Jorma Säteri, Helka Backman, Sisäilmastoseminaari 2013 : 13.3.2013.Sisäilmayhdistys ry, Helsinki. SIY Raportti 31. 13-18. 2013 -
Acute systemic lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies
Uski O, Happo MS, Jalava PI, Brunner T, Kelz J, Obernberger I, Jokiniemi J, Hirvonen M-R.. INHALATION TOXICOLOGY 24 14: 952-965. 2012 -
Cytotoxicity and genotoxicity of emission particles from heavy EURO4 engine operated with conventional and biobased diesel fuels and compressed natural gas
Jalava P, Happo M, Murtonen T, Yli-Pirilä P, Hakulinen P, Aakko-Saksa P, Mäki-Paakkanen J, Jokiniemi J, Hirvonen M-R. In: (ed.) , EAC 2012 Digital Abstract Book. ss. P259. 2012 -
Development of atopic dermatitis according to age of onset and association with early-life exposures
Roduit Caroline, Frei Remo, Loss Georg, Büchele Gisela, Weber Juliane, Depner Martin, Loeliger Susanne, Dalphin Marie-Laure, Roponen Marjut, Hyvärinen Anne, Riedler Josef, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Braun-Fahrländer Charlotte, Lauener Roger, PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 130 1: 130-136. 2012 -
Effects of different combustion conditions on the toxicological properties of PM1 in adjustable biomass combustion reactor
Uski O, Leskinen J, Jalava P, Virén A, Lamberg H, Kaivosoja T, Kettunen T, Nuutinen I, Happo M, Torvela T, Tissari J, Sippula O, Jokiniemi J, Hirvonen M-R / EAC 2012 Digital Abstract Book. 2012. 2012 -
Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles
Tapanainen Maija, Jalava Pasi, Mäki-Paakkanen Jorma, Hakulinen Pasi, Lamberg Heikki, Ruusunen Jarno, Tissari Jarkko, Jokiniemi Jorma, Hirvonen Maija-Riitta. INHALATION TOXICOLOGY 24 6: 343-355. 2012 -
Exhaled nitric oxide and atherosclerosis
Salonen Iiris, Huttunen Kati, Hirvonen Maija-Riitta, Dufva Juhani, Groundstroem Kaj, Dufva Hilkka, Salonen Raimo. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 42 8: 873-880. 2012 -
Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas
Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin J-C, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J, the PASTURE Study Group. CLINICAL AND EXPERIMENTAL ALLERGY 42 8: 1246-1256. 2012 -
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children
Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin JC, Buechele G, Lauener R, Braun-Fahrländer C, von Mutius E, Pekkanen J, the PASTURE Study Group, 19 jäsentä; Remes S. PEDIATRIC ALLERGY AND IMMUNOLOGY 23 6: 522-528. 2012 -
High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy
Lappalainen Mikko Harri Juhani, Hyvärinen Anne, Hirvonen Maija-Riitta, Rintala Helena, Roivainen Jarkko, Renz Harald, Pfefferle Petra Ina, Nevalainen Aino, Roponen Marjut, Pekkanen Juha. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 159: 194-203. 2012 -
In vitro toxicological characterization of particulate emissions from residential biomass heating systems based on old and new technologies
Jalava Pasi, Happo Mikko, Kelz Joachim, Brunner Thomas, Hakulinen Pasi, Mäki-Paakkanen Jorma, Hukkanen Annika, Jokiniemi Jorma, Obernberger Ingwald, Hirvonen Maija-Riitta. ATMOSPHERIC ENVIRONMENT 50: 24-35. 2012 -
Kosteusvauriuituneiden koulujen pölynäytteiden vaikutus immuunipuolustuksen soluihin: HITEA-tutkimuksen tuloksia
Huttunen Kati, Täubel Martin, Pekkanen Juha, Hyvärinen Anne, Heederik Dick, Zock Jan-Paul, Hirvonen Maija-Riitta. Säteri, J. ja Backman H. (toim.), Sisäilmastoseminaari 2012. 151-154. 2012 -
Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients
Huttunen Kati, Siponen Taina, Salonen Iiris, Yli-Tuomi Tarja, Aurela Minna, Dufva Hilkka, Hillamo Risto, Linkola Eeva, Pekkanen Juha, Pennanen Arto, Peters Annette, Salonen Raimo, Schneider Alexandra, Tiittanen Pekka, Hirvonen Maija-Riitta, Lanki Timo. ENVIRONMENTAL RESEARCH 116: 44-51. 2012 -
Occurrence of moisture problems in schools in three countries from different climatic regions of Europe based on questionnaires and building inspections - the HITEA study.
Haverinen-Shaughnessy U, Borras-Santos A, Turunen M, Zock JP, Jacobs J, Krop EJ, Casas L, Shaughnessy R, Täubel M, Heederik D, Hyvärinen A, Pekkanen J, Nevalainen A; HITEA study group (Bloom E, Chen CM, Doekes G, Heinrich J, Hirvonen MR, Huttunen K, Jarvis D, Krska R, Leppänen H, Peitzsch M,, Rintala H, Roponen M, Sulyok M, Sunyer J,Tischer C, Torrens M, Tiittanen P, Valkonen M, Vepsäläinen A, Vis. INDOOR AIR 22 3: 457-466. 2012 -
Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study
Loss Georg, Bitter Sondhja, Wohlgensinger Johanna, Frei Remo, Roduit Caroline, Genuneit Jon, Pekkanen Juha, Roponen Marjut, Hirvonen Maija-Riitta, Dalphin Jean-Charles, Dalphin Marie-Laure, Riedler Josef, von Mutius Erika, Weber Juliane, Kabesch Michael, Michel Sven, Braun-Fahrländer Charlotte, Lauener Roger, PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 130 2: 523-530. 2012 -
Pulmonary inflammation and tissue damage in the mouse lung after exposure to PM samples from biomass heating appliances of old and modern technologies
Happo MS, Uski O, Jalava PI, Kelz J, Brunner T, Hakulinen P, Mäki-Paakkanen J, Kosma VM, Jokiniemi J, Obernberger I, Hirvonen M-R. SCIENCE OF THE TOTAL ENVIRONMENT 443: 256-266. 2012 -
Serum myeloperoxidase is independent of the risk factors of atherosclerosis
Salonen Iiris, Huttunen Kati, Hirvonen Maija-Riitta, Dufva Juhani, Groundstroem Kaj, Dufva Hilkka, Pekkanen Juha, Salonen Raimo. CORONARY ARTERY DISEASE 23: 251-258. 2012 -
Toxicological properties of emission particles from heavy duty engines powered by conventional and bio-based diesel fuels and compressed natural gas
Jalava Pasi, Aakko-Saksa Päivi, Murtonen Timo, Happo Mikko, Markkanen Ari, Yli-Pirilä Pasi, Hakulinen Pasi, Hillamo Risto, Mäki-Paakkanen Jorma, Salonen Raimo, Jokiniemi Jorma, Hirvonen Maija-Riitta. Particle and Fibre Toxicology 9: 37. 2012 -
A novel particle sampling system for physico-chemical and toxicological characterization of emissions
Ruusunen Jarno, Tapanainen Maija, Sippula Olli, Jalava Pasi I, Lamberg Heikki, Nuutinen Kati, Tissari Jarkko, Ihalainen Mika, Kuuspalo Kari, Mäki-Paakkanen Jorma, Hakulinen Pasi, Pennanen Arto, Teinilä Kimmo, Makkonen Ulla, Salonen Raimo O, Hillamo Risto, Hirvonen Maija-Riitta, Jokiniemi Jorma. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 401 10: 3183-3195. 2011 -
Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
Bomert M, Köllisch G, Roponen M, Lauener R, Renz H, Pfefferle PI, Al-Fakhri N. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 49 10: 1691-1693. 2011 -
Determinants of stimulated peripheral blood cytokine production among farming women
Lampi J, Roponen M, Hyvärinen A, Hirvonen MR, Larsson L, Nevalainen A, Pekkanen J. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 214 3: 205-209. 2011 -
In vitro immunotoxic and genotoxic activities of particles emitted from two different small-scale wood combustion appliances
Tapanainen Maija, Jalava Pasi I., Mäki-Paakkanen Jorma, Hakulinen Pasi, Happo Mikko S., Lamberg Heikki, Ruusunen Jarno, Tissari Jarkko, Nuutinen Kati, Yli-Pirilä Pasi, Hillamo Risto, Salonen Raimo O., Jokiniemi Jorma, Hirvonen Maija-Riitta. ATMOSPHERIC ENVIRONMENT 45 40: 7546-7554. 2011 -
Physicochemical characterization of fine particles from small-scale wood combustion
Lamberg Heikki, Nuutinen Kati, Tissari Jarkko, Ruusunen Jarno, Yli-Pirilä Pasi, Sippula Olli, Tapanainen Maija, Jalava Pasi, Makkonen Ulla, Teinilä Kimmo, Saarnio Karri, Hillamo Risto, Hirvonen Maija-Riitta, Jokiniemi Jorma. ATMOSPHERIC ENVIRONMENT 45: 7635-7643. 2011 -
Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis
Roduit C, Wohlgensinger J, Frei R, Bitter S, Bieli C, Loeliger S, Büchele G, Riedler J, Dalphin JC, Remes S, Roponen M, Pekkanen J, Kabesch M, Schaub B, von Mutius E, Braun-Fahrländer C, Lauener R; PASTURE Study Group.. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 127 1: 179-185. 2011 -
Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study
Pfefferle PI, Büchele G, Blümer N, Roponen M, Ege MJ, Krauss-Etschmann S, Genuneit J, Hyvärinen A, Hirvonen MR, Lauener R, Pekkanen J, Riedler J, Dalphin JC, Brunekreef B, Braun-Fahrländer C, von Mutius E, Renz H & PASTURE Study Group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 125 1: 108-115. 2010 -
Effect of combustion condition on cytotoxic and inflammatory activity of residential wood combustion particles
Jalava PI, Salonen RO, Nuutinen K, Pennanen AS, Happo MS, Tissari J, Frey A, Hillamo R, Jokiniemi J & Hirvonen M-R. ATMOSPHERIC ENVIRONMENT 44: 1691-1698. 2010 -
Exposure to dogs is associated with a decreased tumour necrosis factor-α -producing capacity in early life
Lappalainen MHJ, Huttunen K, Roponen M, Remes S, Hirvonen M-R & Pekkanen J. 2010. Exposure to dogs is associated with a decreased tumour necrosis factor-α-producing capacity in early life. Clinical & Experimental Allergy 40 10: 1498- 2010 -
Immunotoxicological properties of airborne particles at landfill, urban and rural sites and their relation to microbial concentrations
Huttunen K, Kaarakainen P, Meklin T, Nevalainen A & Hirvonen M-R. JOURNAL OF ENVIRONMENTAL MONITORING 12: 1368-1374. 2010 -
Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Dormans JAMA, Gerlofs-Nijland ME, Cassee FR, Kosma V-M, Sillanpää M, Hillamo R & Hirvonen M-R. INHALATION TOXICOLOGY 22 5: 402-416. 2010 -
Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
Rochat MK, Ege MJ, Plabst D, Steinle J, Bitter S, Braun-Fahrländer C, Dalphin J-C, Riedler J, Roponen M, Hirvonen M-R, Büchele G, Renz H, Lauener R, Krauss-Etschmann S, Von Mutius E &the PASTURE Study group. CLINICAL AND EXPERIMENTAL ALLERGY 40 5: 786-794. 2010 -
PM EMISSIONS FROM OLD AND MODERN BIOMASS COMBUSTION SYSTEMS AND THEIR HEALTH EFFECTS
Kelz J, Brunner T, Obernberger I, Jalava P & Hirvonen M-R. -, Proceedings of 18th European Biomass conference. 1231-1244. 2010 -
Physicochemical characterisation of fine particles from small scale wood combustion for toxicological studies
Lamberg H, Nuutinen K, Tissari J, Ruusunen J, Pennanen AS, Tapanainen M, Jalava PI, Makkonen U, Hillamo R, Hirvonen M-R & Jokiniemi J. In: (ed.) , American Association for Aerosol Research (AAAR): Air pollution and health. ss. 00. 2010 -
Physicochemical characterization of fine particles from small scale wood combustion
Lamberg H, Nuutinen K, Tissari J, Ruusunen J, Yli-Pirilä P, Sippula O, Tapanainen M, Jalava PI, Makkonen U, Teinilä K, Hillamo R, Hirvonen M-R & Jokiniemi J. , International Aerosol Conference, Helsinki. Abstract P3Q1/4A0. 2010 -
Production of interleukin-5, -10 and interferon-g in cord blood is strongly associated with the season of birth
Keski-Nisula L, Lappalainen MHJ, Mustonen K, Hirvonen M-R, Pfefferle PI, Renz H, Pekkanen J & Roponen M. CLINICAL AND EXPERIMENTAL ALLERGY 40: 1658-1668. 2010 -
Seasonal variation in chemical composition of size-segregated urban air particles and the inflammatory activity in the mouse lung
Happo MS, Hirvonen M-R, Hälinen AI, Jalava PI, Pennanen AS, Sillanpää M, Hillamo R & Salonen RO. INHALATION TOXICOLOGY 22 1: 17-32. 2010 -
The effect of ozonization on furniture dust: Microbial content and immunotoxicity in vitro
Huttunen K, Kauhanen E, Meklin T, Vepsäläinen A, Hirvonen M-R, Hyvärinen A & Nevalainen A. SCIENCE OF THE TOTAL ENVIRONMENT 408 11: 2305-2311. 2010 -
Toll-like receptor 7 function is reduced in adolescents with asthma
Roponen M, Yerkovich ST, Hollams E, Sly PD, Holt PG & Upham JW. EUROPEAN RESPIRATORY JOURNAL 35 1: 64-71. 2010 -
Toxicological effects of emission particles from fossil- and biodiesel-fueled diesel engine with and without DOC/POC catalytic converter
Jalava PI, Tapanainen M, Kuuspalo K, Markkanen A, Hakulinen P, Happo MS, Pennanen AS, Ihalainen M, Yli-Pirilä P, Makkonen U, Teinilä K, Mäki-Paakkanen J, Salonen RO, Jokiniemi J & Hirvonen M-R. INHALATION TOXICOLOGY 22 S2: 48-58. 2010 -
Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line
Jalava PI, Hirvonen M-R, Sillanpää M, Pennanen AS, Happo MS, Hillamo R, Cassee FR, Gerlofs-Nijland M, Borm PJA, Schins RPF, Janssen NAH, Salonen RO. INHALATION TOXICOLOGY 21 12: 994-1006. 2009 -
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress
Markkanen P, Pelkonen J, Tapanainen M, Mäki-Paakkanen J, Jalava PI, Hirvonen M-R.. INHALATION TOXICOLOGY 21: 857-867. 2009 -
Maturation of cytokine-producing capacity from birth to 1 yr of age
Lappalainen MH, Roponen M, Pekkanen J, Huttunen K, Hirvonen M-R. PEDIATRIC ALLERGY AND IMMUNOLOGY 20 8: 714-725. 2009 -
Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples of contrasting air pollution in Europe
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Sillanpää M, Hillamo R, Hirvonen MR. INHALATION TOXICOLOGY 20: 1215-1231. 2008 -
Effects of solubility of urban air coarse and fine particulate samples on cytotoxic and inflammatory responses in RAW 264.7 macrophage cell line
Jalava PI, Salonen RO, Pennanen AS, Happo MS, Penttinen P, Hälinen AI, Sillanpää M, Hillamo R, Hirvonen M-R. TOXICOLOGY AND APPLIED PHARMACOLOGY 229: 146-160. 2008 -
Dose- and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine and ultrafine particles from six European cities
Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Kosma VM, Sillanpää M, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen M-R.. INHALATION TOXICOLOGY 19 3: 227-246. 2007 -
Heterogeneities in inflammatory and cytotoxic responses of RAW 264.7 macrophage cell line to urban air coarse, fine and ultrafine particles from six European sampling campaigns
Jalava PI, Salonen RO, Pennanen AS, Sillanpää M, Hälinen AI, Happo MS, Hillamo R, Brunekreef B, Katsouyanni K, Sunyer J, Hirvonen M-R.. INHALATION TOXICOLOGY 19 3: 213-225. 2007 -
Inflammatory and cytotoxic effects of size-segregated particulate samples collected during long-range transport of wildfire smoke to Helsinki
Jalava PI, Salonen RO, Hälinen AI, Penttinen P, Pennanen AS, Sillapää M, Sandell E, Hillamo R, Hirvonen M-R.. TOXICOLOGY AND APPLIED PHARMACOLOGY 215: 341-353. 2006 -
Effects of sample preparation on chemistry, cytotoxicity and inflammatory responses induced by air particulate matter
Jalava P, Salonen RO, Hälinen AI, Sillanpää M, Sandell E, Hirvonen M-R.. INHALATION TOXICOLOGY 17: 107-117. 2005 -
Amoebae and other protozoa in material samples from moisture-damaged buildings
Yli-Pirila T, Kusnetsov J, Haatainen S, Hanninen M, Jalava P, Reiman M, Seuri M, Hirvonen MR, Nevalainen A. ENVIRONMENTAL RESEARCH 96 3: 250-256. 2004 -
Inflammatory responses in RAW264.7 macrophages caused by mycobacteria isolated from moldy houses
Huttunen K, Ruotsalainen M, Iivanainen E, Torkko P, Katila M-L, Hirvonen M-R. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 8: 237-244. 2000