Latonen Lab - Cancer stress biology
Leaders
We study the molecular, cellular and tissue mechanisms that contribute to the increased ability of cancer cells to tolerate stress. We focus on the molecular mechanisms behind the different capacities of cancer and neuronal cells to deal with protein and RNA aggregates, and the ability of cancer cells to form resistance to drugs. We also query the cancer growth patterns in tissue combining this to molecular information in order to better understand the mechanisms behind cancer cells’ ability to survive in the crossfire of different stress types. In our tissue analysis collaboration projects we search for better ways to image, visualise and quantitatively analyse histology with development of digital pathology, machine learning and AI tools. Our research aims at developing better diagnostic tools and novel cancer treatments.
Leaders
Post-doctoral Researchers
Doctoral Researchers
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Sonja Koivukoski
Visiting ResearcherInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Nithin Sadeesh
Project ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology
Technicians
Other group members
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Nikolas Nurmesviita
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Miia Romo
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Elina Kallio
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Siiri Sirviö
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Jenni Ruokolainen
Publications
22 items-
Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images
Koivukoski, Sonja; Khan, Umair; Ruusuvuori, Pekka; Latonen, Leena. 2023. Laboratory investigation. 103: -
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
Tollis, Sylvain; Rizzotto, Andrea; Pham, Nhan T; Koivukoski, Sonja; Sivakumar, Aishwarya; Shave, Steven; Wildenhain, Jan; Zuleger, Nikolaj; Keys, Jeremy T; Culley, Jayne; Zheng, Yijing; Lammerding, Jan; Carragher, Neil O; Brunton, Valerie G; Latonen, Leena; Auer, Manfred; Tyers, Mike; Schirmer, Eric C. 2022. Acs chemical biology. 17: 680-700 -
Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen
Kukkonen, Konsta; Autio-Kimura, Bryn; Rauhala, Hanna; Kesseli, Juha; Nykter, Matti; Latonen, Leena; Visakorpi, Tapio. 2022. Endocrine-related cancer. 29: 717–733 -
Nuclear Organization in Response to Stress: A Special Focus on Nucleoli
Batnasan, Enkhzaya; Koivukoski, Sonja; Kärkkäinen, Minttu; Latonen, Leena. Teoksessa: Kloc, Malgorzat ; Kubiak, Jacek Z(toim.) , 2022. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. s. 469-494. Springer -
Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
Schirmer, Eric C; Latonen, Leena; Tollis, Sylvain. 2022. Frontiers in cell and developmental biology. 10: . 1022723 -
Spatial analysis of histology in 3D: quantification and visualization of organ and tumor level tissue environment
Ruusuvuori, Pekka; Valkonen, Masi; Kartasalo, Kimmo; Valkonen, Mira; Visakorpi, Tapio; Nykter, Matti; Latonen, Leena. 2022. Heliyon. 8: -
miR-32 promotes MYC-driven prostate cancer
Scaravilli, Mauro; Koivukoski, Sonja; Gillen, Andrew; Bouazza, Aya; Ruusuvuori, Pekka; Visakorpi, Tapio; Latonen, Leena. 2022. Oncogenesis. 11: . 11 -
A systematic comparison of data- and knowledge-driven approaches to disease subtype discovery
Rintala, TJ; Federico, A; Latonen, L; Greco, D; Fortino, V. 2021. Briefings in bioinformatics. 22: bbab314 -
Androgen-Driven Fusion Genes and Chimeric Transcripts in Prostate Cancer
Scaravilli, Mauro; Koivukoski, Sonja; Latonen, Leena. 2021. Frontiers in cell and developmental biology. 9: 623809 -
Building a central repository landmarks a new era for artificial intelligence - assisted digital pathology development in Europe
Latonen, Leena; Ruusuvuori, Pekka. 2021. European journal of cancer. 150: 31-32