Neurobiology of schizophrenia

Group leader:
Professor Jari Tiihonen

Research topics and goals:

• To elucidate gene expression and molecular signaling pathways associated with schizophrenia.

Latest achievements:

• The results from Tiihonen et al. 2019 (Nat Comm) provided the first evidence that the pathophysiology of schizophrenia differs between males and females and provided explanation why symptoms appear after adolescence when the expression of many sex-specific genes change, suggesting the need for sex-specific treatments.

Research methods:

• Stem cell research

Collaboration:

• Karolinska Institutet, Stockholm, Sweden
• University of Helsinki, National Institute for Health and Welfare
• Yale University, USA
• La Trobe University, Bundoora, Australia.

Selected publications:

• Tiihonen J, Koskuvi M, Storvik M, Hyötyläinen I, Gao Y, Puttonen KA, Giniatullina R, Poguzhelskaya E, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Cheng L, Hill AF, Lähteenvuo M, Tohka J, Giniatullin R, Lehtonen Š, Koistinaho J: Sex-specific transcriptional and proteomic signatures in schizophrenia. Nat Commun 2019;10(1):3933.

Keywords

Group members - UEF