Neurobiology of schizophrenia
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Jari TiihonenProfessorInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Research topics and goals
- To elucidate gene expression and molecular signaling pathways associated with schizophrenia.
- The results from Tiihonen et al. 2019 (Nat Comm) provided the first evidence that the pathophysiology of schizophrenia differs between males and females and provided explanation why symptoms appear after adolescence when the expression of many sex-specific genes change, suggesting the need for sex-specific treatments.
- Stem cell research
Sex-specific transcriptional and proteomic signatures in schizophreniaTiihonen, J; Koskuvi, M; Storvik, M; Hyötyläinen, I; Gao, Y; Puttonen, KA; Giniatullina, R; Poguzhelskaya, E; Ojansuu, I; Vaurio, O; Cannon, TD; Lönnqvist, J; Therman, S; Suvisaari, J; Kaprio, J; Cheng, L; Hill, AF; Lähteenvuo, M; Tohka, J; Giniatullin, R; et al.. 2019. Nature communications. 10: 3933