Neuromodulation research group
Leaders
Neuronavigated transcranial magnetic stimulation, where a coil is used to target quickly changing magnetic field onto the cortex of the brain to induce electric field, which in turn activates the neurons of the cortex. Consequenly, muscle contraction may follow the stimulation. Activation of the cortical neurons can be modelled and studied. When mapping the cortical representation of a muscle, electric field modeling can be utilized to quantify the representation size and location.
Our research focuses on the neuromodulation, functional imaging, theoretical assessment and biomechanical measurement of the neuromuscular function connecting the human brains to motion. Our main focus is in the quantitative analysis motor function, and motor cortical control of muscle action. In addition, we have a general focus on methodological development of the navigated transcranial magnetic stimulation methodology, technology and response analysis tools to improve the accuracy and applicability of mapping the motor function as well as increasing the efficiency of neuromodulation treatments with navigated repetitive transcranial magnetic stimulation (rTMS).
The key methods we apply and develop are navigated transcranial magnetic stimulation, electromyography, electroencephalography (TMS-EEG), modeling of neural function, motion analysis, radiological imaging and biomechanical tests and modeling. We actively collaborate with other national and international research groups. Our research group includes members who are specialists in medicine, physics and biomedical engineering. Neuromodulation research group also operates as a member of the ”Musculoskeletal diseases” research community.
We are funded by:
- Academy of Finland
- Finnish Cancer Society
- Doctoral programme in Science, Technology and Computing (SCITECO)
- State research funding
- Orion Research Foundation
- Other private foundations
News
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Team for TMS-EEG formed to develop reproducibility of TMS-EEGTeam for TMS-EEG formed to develop reproducibility of TMS-EEG
T4TE provides a framework for the TMS-EEG community to join in an international collaborative effort, with the aim of improving the quality of TMS-EEG… -
PhD student wanted
We are inviting applications for Doctoral Researcher position in Transcranial Magnetic Stimulation at the Department of Applied Physics on the Kuopio… -
BP-Pain project to reach analysis phase
The Academy of Finland -funded BP-Pain consortium, studying the multidiciplinary effects of osteoarthritic pain, has finalized all recruitments and…
Cooperation
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Manufacturer of neuromodulation systems
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Medical technology company and manufacturer of TMS-EEG systems
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Laboratory of Clinical Neurophysiology, Aristotle University of Thessaloniki, Greece
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Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo
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Department of Neurosurgery at the Technische Universität München, Germany
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New Jersey Institute of Technology, New Jersey, USA
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University of Eastern Finland / Epilepsy Center, Kuopio University Hospital, Kuopio, Finland
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University of Eastern Finland / Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
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School of Medicine, University of Eastern Finland
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Department of Otolaryngology, Kuopio University Hospital, Kuopio, Finland
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Biophysics of Bone and Cartilage (BBC) 01.01.1998 - -
Pain Neuromodulation Group 01.01.2022 - -
Biosignal Analysis and Medical Imaging research group (BSAMIG) 01.01.1994 - -
Clinical Epilepsy Research 01.01.2010 -
Keywords
Leaders
Senior Researchers
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Laura Säisänen
Senior ResearcherInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Virpi Laukkanen
Post-doctoral Researchers
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Amir Esrafilian
Postdoctoral ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology -
Paavo Vartiainen
Project ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology
Doctoral Researchers
Other group members
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Jusa Reijonen / Post-Doctoral researcher and Specializing medical physicist jusa.reijonen@pshyvinvointialue.fi
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Minna Pitkänen / Post-Doctoral researcher
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Nils Danner / Senior researcher, Neurosurgeon
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Jani Sirkka / PhD student
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Mervi Könönen / Docent
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Jari Karhu / Docent
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Jelena Hypponen / MD, PhD, Academy Fellow
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Olli Löfberg / MD, PhD, Post-doctoral researcher
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Anna-Leena Voutilainen / Study Nurse anna-leena.voutilainen@pshyvinvointialue.fi
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Joel Naukkarinen / PhD Student
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Zunaira Jamil / PhD Student
Publications
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Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis
Mustonen, Anne-Mari; Palviainen, Mari; Säisänen, Laura; Karttunen, Lauri; Tollis, Sylvain; Esrafilian, Amir; Reijonen, Jusa; Julkunen, Petro; Siljander, Pia R-M; Kröger, Heikki; Mäki, Jussi; Arokoski, Jari; Nieminen, Petteri. 2024. Arthritis research and therapy. 26: . 33 -
Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood
Nguyen, Dao T A; Julkunen, Petro; Säisänen, Laura; Määttä, Sara; Rissanen, Saara M; Lintu, Niina; Könönen, Mervi; Lakka, Timo; Karjalainen, Pasi A. 2023. Scientific reports. 13: -
Near-threshold recruitment characteristics of motor evoked potentials in transcranial magnetic stimulation
Demjan, Michal; Säisänen, Laura; Reijonen, Jusa; Rissanen, Saara; Määttä, Sara; Julkunen, Petro. 2023. Brain research. 1805: -
TMS combined with EEG: Recommendations and open issues for data collection and analysis
Hernandez-Pavon, Julio C; Veniero, Domenica; Bergmann, Til Ole; Belardinelli, Paolo; Bortoletto, Marta; Casarotto, Silvia; Casula, Elias P; Farzan, Faranak; Fecchio, Matteo; Julkunen, Petro; Kallioniemi, Elisa; Lioumis, Pantelis; Metsomaa, Johanna; Miniussi, Carlo; Mutanen, Tuomas P; Rocchi, Lorenzo; Rogasch, Nigel C; Shafi, Mouhsin M; Siebner, Hartwig R; Thut, Gregor; Zrenner, Christoph; Ziemann, Ulf; Ilmoniemi, Risto J. 2023. Brain stimulation. 16: 567-593 -
Bridging the gap: TMS-EEG from lab to clinic
Julkunen, Petro; Kimiskidis, Vasilios K; Belardinelli, Paolo. 2022. Journal of neuroscience methods. 369: -
Efficacy and tolerability in patients with chronic facial pain of two consecutive treatment periods of rTMS applied over the facial motor cortex, using protocols differing in stimulation frequency, duration, and train pattern
Säisänen, Laura; Huttunen, Jukka; Hyppönen, Jelena; Nissen, Mette; Kotiranta, Ulla; Mervaala, Esa; Fraunberg, Mikael von und zu. 2022. Neurophysiologie clinique-clinical neurophysiology. 52: 95-108 -
Short‐ and long‐interval intracortical inhibition in EPM1 is related to genotype
Silvennoinen, Katri; Säisänen, Laura; Hyppönen, Jelena; Rissanen, Saara M; Karjalainen, Pasi A; D’Ambrosio, Sasha; Jimenez‐Jimenez, Diego; Zagaglia, Sara; Rothwell, John C; Balestrini, Simona; Sisodiya, Sanjay M; Julkunen, Petro; Mervaala, Esa; Kälviäinen, Reetta. 2022. Epilepsia. 2023; 64: 208-217 -
T4TE: Team for TMS−EEG and improve reproducibility through an open collaborative initiative
Bortoletto, Marta; Veniero, Domenica; Julkunen, Petro; Hernandez-Pavon, Julio C.; Mutanen, Tuomas P.; Zazio, Agnese; Bagattini, Chiara. 2022. Brain stimulation. 2023; 16: 20-22 -
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
Sirkka, Jani; Säisänen, Laura; Julkunen, Petro; Könönen, Mervi; Kallioniemi, Elisa; Leinonen, Ville; Danner, Nils. 2022. Fluids and barriers of the cns. 19: . 89 -
Navigoitu TMS (nTMS) ja neuromodulaatio: Kliiniset käyttöaiheet
Julkunen, Petro; Säisänen, Laura. Teoksessa: Mervaala, Esa; Haaksiluoto, Erika; Himanen, Sari-Leena; Jääskeläinen, Satu; Kallio, Mika; Vanhatalo, Sampsa(toim.) , 2019. Kliininen neurofysiologia. s. 356-361. Kustannus Oy Duodecim