Neuromodulation research group

Research group

01.01.2017 -

Department of Technical Physics, Faculty of Science, Forestry and Technology

Information People Publications

Leaders

Petro Julkunen

Professor

Department of Technical Physics, Faculty of Science, Forestry and Technology

Group description

Neuronavigated transcranial magnetic stimulation, where a coil is used to target quickly changing magnetic field onto the cortex of the brain to induce electric field, which in turn activates the neurons of the cortex. Consequenly, muscle contraction may follow the stimulation. Activation of the cortical neurons can be modelled and studied. When mapping the cortical representation of a muscle, electric field modeling can be utilized to quantify the representation size and location.

Our research focuses on the neuromodulation, functional imaging, theoretical assessment and biomechanical measurement of the neuromuscular function connecting the human brains to motion. Our main focus is in the quantitative analysis motor function, and motor cortical control of muscle action. In addition, we have a general focus on methodological development of the navigated transcranial magnetic stimulation methodology, technology and response analysis tools to improve the accuracy and applicability of mapping the motor function as well as increasing the efficiency of neuromodulation treatments with navigated repetitive transcranial magnetic stimulation (rTMS).

The key methods we apply and develop are navigated transcranial magnetic stimulation, electromyography, electroencephalography (TMS-EEG), modeling of neural function, motion analysis, radiological imaging and biomechanical tests and modeling. We actively collaborate with other national and international research groups. Our research group includes members who are specialists in medicine, physics and biomedical engineering. Neuromodulation research group also operates as a member of the ”Musculoskeletal diseases” research community.

We are funded by:

Academy of Finland
Finnish Cancer Society
Doctoral programme in Science, Technology and Computing (SCITECO)
State research funding
Orion Research Foundation
Other private foundations

News

Team for TMS-EEG formed to develop reproducibility of TMS-EEG

T4TE provides a framework for the TMS-EEG community to join in an international collaborative effort, with the aim of improving the quality of TMS-EEG…

Team for TMS-EEG formed to develop reproducibility of TMS-EEG
PhD student wanted

We are inviting applications for Doctoral Researcher position in Transcranial Magnetic Stimulation at the Department of Applied Physics on the Kuopio…
BP-Pain project to reach analysis phase

The Academy of Finland -funded BP-Pain consortium, studying the multidiciplinary effects of osteoarthritic pain, has finalized all recruitments and…

Cooperation

Nexstim Plc

Manufacturer of neuromodulation systems
Bittium Ltd

Medical technology company and manufacturer of TMS-EEG systems
Associate Professor Vasilios Kimiskidis

Laboratory of Clinical Neurophysiology, Aristotle University of Thessaloniki, Greece
Professor Risto Ilmoniemi

Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo
Professor Sandro Krieg, MD, PhD

Department of Neurosurgery at the Technische Universität München, Germany
Assistant Professor Elisa Kallioniemi, PhD

New Jersey Institute of Technology, New Jersey, USA
Professor Reetta Kälviäinen

University of Eastern Finland / Epilepsy Center, Kuopio University Hospital, Kuopio, Finland
Professor Esa Mervaala

University of Eastern Finland / Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
Professor Petteri Nieminen

School of Medicine, University of Eastern Finland
Team for TMS-EEG (T4TE)
Docent Aarno Dietz

Department of Otolaryngology, Kuopio University Hospital, Kuopio, Finland

Keywords

biomechanics brain brain imaging brain research clinical neurophysiology motion analysis motor-evoked potential muscle neuroimaging plasticity

Leaders

Petro Julkunen

Professor

Department of Technical Physics, Faculty of Science, Forestry and Technology

Senior Researchers

Post-doctoral Researchers

Doctoral Researchers

Research Nurses

Other group members

Jusa Reijonen / Post-Doctoral researcher and Specializing medical physicist
Minna Pitkänen / Post-Doctoral researcher
Nils Danner / Senior researcher, Neurosurgeon
Jani Sirkka / PhD student
Mervi Könönen / Docent
Jari Karhu / Docent
Jelena Hypponen / MD, PhD, Academy Fellow
Olli Löfberg / MD, PhD, Post-doctoral researcher
Anna-Leena Voutilainen / Study Nurse
Joel Naukkarinen / PhD Student
Zunaira Jamil / PhD Student

Publications

78 items

Neuromodulation research group

Leaders

Petro Julkunen

Group description

News

Team for TMS-EEG formed to develop reproducibility of TMS-EEG

PhD student wanted

BP-Pain project to reach analysis phase

Cooperation

Keywords

Leaders

Petro Julkunen

Senior Researchers

Laura Säisänen

Virpi Laukkanen

Post-doctoral Researchers

Amir Esrafilian

Paavo Vartiainen

Doctoral Researchers

Dao Nguyen

Michal Demjan

Research Nurses

Other group members

Atlas-informed computational processing pipeline for individual targeting of brain areas for therapeutic navigated transcranial magnetic stimulation

Fast acquisition of resting motor threshold with a stimulus-response curve - Possibility or hazard for transcranial magnetic stimulation applications?

Mapping of Motor Function with Neuronavigated Transcranial Magnetic Stimulation: A Review on Clinical Application in Brain Tumors and Methods for Ensuring Feasible Accuracy

Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus

Wearable monitoring of positive and negative myoclonus in progressive myoclonic epilepsy type 1

Brain Response Induced with Paired Associative Stimulation Is Related to Repetition Suppression of Motor Evoked Potential

Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study

Mechanobiological Model for Simulation of Injured Cartilage Degradation via Pro-Inflammatory Cytokines and Mechanical Stimulus

Navigated transcranial magnetic stimulation planning using a structural effectiveness index

Paired-pulse navigated TMS is more effective than single-pulse navigated TMS for mapping upper extremity muscles in brain tumor patients

Primary hand motor representation areas in healthy children, preadolescents, adolescents, and adults

Short-Interval Intracortical Facilitation Improves Efficacy in nTMS Motor Mapping of Lower Extremity Muscle Representations in Patients with Supra-Tentorial Brain Tumors

Spatial extent of cortical motor hotspot in navigated transcranial magnetic stimulation

Cortical Inhibition of Face and Jaw Muscle Activity and Discomfort Induced by Repetitive and Paired-Pulse TMS During an Overt Object Naming Task

Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study

Interaction between repetition suppression in motor activation and long-interval intracortical inhibition

Mobile Application for Adaptive Threshold Hunting in Transcranial Magnetic Stimulation

Principal Component Regression on Motor Evoked Potential in Single-Pulse Transcranial Magnetic Stimulation

Reproducibility in TMS-EEG studies: A call for data sharing, standard procedures and effective experimental control

The effect of coil placement and orientation on the assessment of focal excitability in motor mapping with navigated transcranial magnetic stimulation

Abnormal motor cortical adaptation to external stimulus in Unverricht-Lundborg disease (progressive myoclonus type 1, EPM1)

Development of corticospinal motor excitability and cortical silent period from mid-childhood to adulthood - a navigated TMS study

Efficient Mapping of the Motor Cortex with Navigated Biphasic Paired-Pulse Transcranial Magnetic Stimulation

Individual Characterization of Fast Intracortical Facilitation With Paired Biphasic-Wave Tanscranial Magnetic Stimulation

Modulation of motor cortical excitability with auditory stimulation

Transcranial magnetic stimulation modulation of corticospinal excitability by targeting cortical I-waves with biphasic paired-pulses

Brain plasticity in neurosurgery

Development of cortical motor circuits between childhood and adulthood: A navigated TMS-HdEEG study

Effect of inter-train interval on the induction of repetition suppression of motor-evoked potentials using transcranial magnetic stimulation

Infrared thermography reveals effect of working posture on skin temperature in office workers

Minimum-Norm Estimation of Motor Representations in Navigated TMS Mappings

Oscillatory TMS-EEG-responses as a Measure of the Cortical Excitability Threshold

Treatment of paresis

Alternative Stimulation Intensities for Mapping Cortical Motor Area with Navigated TMS

Facilitatory effect of paired-pulse stimulation by transcranial magnetic stimulation with biphasic wave-form

Functional and structural cortical characteristics after restricted focal motor cortical infarction evaluated at chronic stage : Indications from a preliminary study

Increased Inhibition in Non-Primary Motor Areas of String-Instrument Players: A Preliminary Study with Paired-Pulse Transcranial Magnetic Stimulation

Localization of cortical primary motor area of the hand using navigated transcranial magnetic stimulation, BOLD and arterial spin labeling fMRI

Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke

Motor plasticity after extra-intracranial bypass surgery in occlusive cerebrovascular disease

Extent and Location of the Excitatory and Inhibitory Cortical Hand Representation Maps: A Navigated Transcranial Magnetic Stimulation Study

Functional neuronal anisotropy assessed with neuronavigated transcranial magnetic stimulation

Input-Output Characteristics of Late Corticospinal Silent Period Induced by Transcranial Magnetic Stimulation

Locating and Outlining the Cortical Motor Representation Areas of Facial Muscles With Navigated Transcranial Magnetic Stimulation

Menthol concentration in topical cold gel does not have significant effect on skin cooling

Motor cortical alterations in children with Asperger's syndrome studied with navigated TMS

Non-invasive mapping of bilateral motor speech areas using navigated transcranial magnetic stimulation and functional magnetic resonance imaging

Onset Latency of Motor Evoked Potentials in Motor Cortical Mapping with Neuronavigated Transcranial Magnetic Stimulation

Refining the phenotype of Unverricht-Lundborg disease (EPM1): a population-wide Finnish study

Repeatability of functional anisotropy in navigated transcranial magnetic stimulation - coil-orientation versus response

Repetition suppression in transcranial magnetic stimulation-induced motor-evoked potentials is modulated by cortical inhibition

Thermal imaging in screening of joint inflammation and rheumatoid arthritis in children

Methods for estimating cortical motor representation size and location in navigated transcranial magnetic stimulation

On the estimation of silent period thresholds in transcranial magnetic stimulation

The auditory-evoked arousal modulates motor cortex excitability

Alterations of motor cortical excitability and anatomy in Unverricht-Lundborg disease

Feasibility of automated analysis and inter-examiner variability of cortical silent period induced by transcranial magnetic stimulation