
Neuromodulation research group
Leaders
Group description

Neuronavigated transcranial magnetic stimulation, where a coil is used to target quickly changing magnetic field onto the cortex of the brain to induce electric field, which in turn activates the neurons of the cortex. Consequenly, muscle contraction may follow the stimulation. Activation of the cortical neurons can be modelled and studied. When mapping the cortical representation of a muscle, electric field modeling can be utilized to quantify the representation size and location.
Our research focuses on the neuromodulation, functional imaging, theoretical assessment and biomechanical measurement of the neuromuscular function connecting the human brains to motion. Our main focus is in the quantitative analysis motor function, and motor cortical control of muscle action. In addition, we have a general focus on methodological development of the navigated transcranial magnetic stimulation methodology, technology and response analysis tools to improve the accuracy and applicability of mapping the motor function as well as increasing the efficiency of neuromodulation treatments with navigated repetitive transcranial magnetic stimulation (rTMS).
The key methods we apply and develop are navigated transcranial magnetic stimulation, electromyography, electroencephalography (TMS-EEG), modeling of neural function, motion analysis, radiological imaging and biomechanical tests and modeling. We actively collaborate with other national and international research groups. Our research group includes members who are specialists in medicine, physics and biomedical engineering. Neuromodulation research group also operates as a member of the ”Musculoskeletal diseases” research community.
We are funded by:
- Academy of Finland
- Finnish Cancer Society
- Doctoral programme in Science, Technology and Computing (SCITECO)
- State research funding
- Orion Research Foundation
- Other private foundations
News
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Team for TMS-EEG formed to develop reproducibility of TMS-EEG
T4TE provides a framework for the TMS-EEG community to join in an international collaborative effort, with the aim of improving the quality of TMS-EEG… -
PhD student wanted
We are inviting applications for Doctoral Researcher position in Transcranial Magnetic Stimulation at the Department of Applied Physics on the Kuopio… -
BP-Pain project to reach analysis phase
The Academy of Finland -funded BP-Pain consortium, studying the multidiciplinary effects of osteoarthritic pain, has finalized all recruitments and…
Cooperation
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Manufacturer of neuromodulation systems
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Medical technology company and manufacturer of TMS-EEG systems
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Laboratory of Clinical Neurophysiology, Aristotle University of Thessaloniki, Greece
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Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo
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Department of Neurosurgery at the Technische Universität München, Germany
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New Jersey Institute of Technology, New Jersey, USA
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University of Eastern Finland / Epilepsy Center, Kuopio University Hospital, Kuopio, Finland
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University of Eastern Finland / Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
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School of Medicine, University of Eastern Finland
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Department of Otolaryngology, Kuopio University Hospital, Kuopio, Finland
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Biophysics of Bone and Cartilage (BBC) 01.01.1998 -
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Pain Neuromodulation Group 01.01.2022 -
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Biosignal Analysis and Medical Imaging research group (BSAMIG) 01.01.1994 -
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Clinical Epilepsy Research 01.01.2010 -
Keywords
Leaders
Senior Researchers
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Laura Säisänen
Senior ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology -
Virpi Laukkanen
Post-doctoral Researchers
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Amir Esrafilian
Postdoctoral ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology -
Paavo Vartiainen
Project ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology
Doctoral Researchers
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Dao Nguyen
Visiting ResearcherDepartment of Technical Physics, Faculty of Science, Forestry and Technology -
Michal Demjan
Researcher
Research Nurses
Other group members
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Jusa Reijonen / Post-Doctoral researcher and Specializing medical physicist
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Minna Pitkänen / Post-Doctoral researcher
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Nils Danner / Senior researcher, Neurosurgeon
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Jani Sirkka / PhD student
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Mervi Könönen / Docent
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Jari Karhu / Docent
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Jelena Hypponen / MD, PhD, Academy Fellow
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Olli Löfberg / MD, PhD, Post-doctoral researcher
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Anna-Leena Voutilainen / Study Nurse
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Joel Naukkarinen / PhD Student
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Zunaira Jamil / PhD Student
Publications
78 items-
Atlas-informed computational processing pipeline for individual targeting of brain areas for therapeutic navigated transcranial magnetic stimulation
Reijonen, Jusa; Könönen, Mervi; Tuunanen, Pasi; Määttä, Sara; Julkunen, Petro. 2021. Clinical neurophysiology. 132: 1612-1621 -
Fast acquisition of resting motor threshold with a stimulus-response curve - Possibility or hazard for transcranial magnetic stimulation applications?
Kallioniemi, Elisa; Awiszus, Friedemann; Pitkänen, Minna; Julkunen, Petro. 2021. Clinical neurophysiology practice. 2022; 7: 7-15 -
Mapping of Motor Function with Neuronavigated Transcranial Magnetic Stimulation: A Review on Clinical Application in Brain Tumors and Methods for Ensuring Feasible Accuracy
Sollmann, Nico; Krieg, Sandro M; Säisänen, Laura; Julkunen, Petro. 2021. Brain sciences. 11: 897 -
Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus
Sirkka, Jani; Parviainen, Marita; Jyrkkänen, Henna-Kaisa; Koivisto, Anne M.; Säisänen, Laura; Rauramaa, Tuomas; Leinonen, Ville; Danner, Nils. 2021. Acta neurochirurgica. 163: 2675-2683 -
Wearable monitoring of positive and negative myoclonus in progressive myoclonic epilepsy type 1
Rissanen, Saara M; Hyppönen, Jelena; Silvennoinen, Katri; Säisänen, Laura; Karjalainen, Pasi A; Mervaala, Esa; Kälviäinen, Reetta. 2021. Clinical neurophysiology. 132: 2464-2472 -
Brain Response Induced with Paired Associative Stimulation Is Related to Repetition Suppression of Motor Evoked Potential
Kariminezhad, Shohreh; Karhu, Jari; Säisänen, Laura; Reijonen, Jusa; Könönen, Mervi; Julkunen, Petro. 2020. Brain sciences. 10: 674 -
Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study
Sirkka, J; Säisänen, L; Julkunen, P; Könönen, M; Kallioniemi, E; Leinonen, V; Danner, N. 2020. Fluids and barriers of the cns. 17: 6 -
Mechanobiological Model for Simulation of Injured Cartilage Degradation via Pro-Inflammatory Cytokines and Mechanical Stimulus
Eskelinen, ASA; Tanska, P; Florea, C; Orozco, GA; Julkunen, P; Grodzinsky, AJ; Korhonen, RK. 2020. PLoS computational biology. 16: 1007998 -
Navigated transcranial magnetic stimulation planning using a structural effectiveness index
Järnefelt Gustaf, Julkunen Petro. 2020. -
Paired-pulse navigated TMS is more effective than single-pulse navigated TMS for mapping upper extremity muscles in brain tumor patients
Sollmann, Nico; Zhang, Haosu; Kelm, Anna; Schröder, Axel; Meyer, Bernhard; Pitkänen, Minna; Julkunen, Petro; Krieg, Sandro M. 2020. Clinical neurophysiology. 131: 2887-2898