Prodrugs and Drug Delivery

Research group

The Prodrug and Drug Delivery group develops chemistry-based methods, especially prodrugs, for improved drug delivery and targeting.

Our research is currently focusing on exploiting the body’s natural mechanisms for transporting nutrients, the LAT1 and GLUT1 proteins, for improved and targeted drug delivery across the blood-brain barrier (BBB) and cancer cells that express these transporters. The focus is on head and neck cancers as well as on brain tumors. We belong to a national research consortium having an aim to develop boron carriers for boron neutron capture therapy (BNCT).
We use computational, in vitro and in vivo tools to build an understanding of cellular uptake mechanisms and quantities as well as preclinical pharmacokinetics of our compounds.