Prodrugs and Drug Delivery
Research group
01.01.2017 -
School of Pharmacy, Faculty of Health Sciences
Leaders
Research in Prodrugs and Drug Delivery group focuses on the chemistry-based methods, especially prodrugs, to overcome drug delivery liabilities of problematic drugs and drug candidates. Our current research is centered on leveraging the body’s natural transport mechanisms for transporting amino acids and glucose, the LAT1 and GLUT1 proteins, respectively, for targeted delivery of drugs and boron carriers for BNCT across the blood-brain barrier (BBB) and cancer cells that express these transporters.
Keywords
Leaders
Senior Researchers
Post-doctoral Researchers
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Juulia Järvinen
Postdoctoral ResearcherSchool of Pharmacy, Faculty of Health Sciences -
Diego Fernando Rodriguez Ibañez
Postdoctoral ResearcherSchool of Pharmacy, Faculty of Health Sciences
Doctoral Researchers
Technicians
Other group members
Publications
12 items-
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195: A1 Journal article (refereed), original research -
Altering distribution profile of palbociclib by its prodrugs
Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192: A1 Journal article (refereed), original research -
Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)
Järvinen, Juulia; Pulkkinen, Herkko; Rautio, Jarkko; Timonen, Juri M. 2023. Pharmaceutics. 15: A2 Review article, Literature review, Systematic review -
Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner
Huttunen, Johanna; Tampio, Janne; Järvinen, Juulia; Montaser, Ahmed B; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M. 2023. Chemico-biological interactions. 2024; 388: A1 Journal article (refereed), original research -
Sweet Battle of the Epimers─Continued Exploration of Monosaccharide-Derived Delivery Agents for Boron Neutron Capture Therapy
Matović, Jelena; Bahrami, Katayun; Stockmann, Philipp; Sokka, Iris K; Khng, You Cheng; Sarparanta, Mirkka; Hey-Hawkins, Evamarie; Rautio, Jarkko; Ekholm, Filip S. 2023. Molecular pharmaceutics. 20: 3127-3139 A1 Journal article (refereed), original research -
Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids
Auchynnikava, Tatsiana; Aarela, Antti; Liljenback, Heidi; Jarvinen, Juulia; Andriana, Putri; Kovacs, Luciana; Rautio, Jarkko; Rajander, Johan; Virta, Pasi; Roivainen, Anne; Li, Xiang-Guo; Airaksinen, Anu J.. 2023. ACS omega. 8: 45326-45336 A1 Journal article (refereed), original research -
Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma
Srisongkram, Tarapong; Bahrami, Katayun; Järvinen, Juulia; Timonen, Juri; Rautio, Jarkko; Weerapreeyakul, Natthida. 2022. International journal of molecular sciences. 23: . 8446 A1 Journal article (refereed), original research -
Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
Bahrami, Katayun; Järvinen, Juulia; Laitinen, Tuomo; Reinisalo, Mika; Honkakoski, Paavo; Poso, Antti; Huttunen, Kristiina M.; Rautio, Jarkko. 2022. Molecular pharmaceutics. 2023; 20: 206-218 A1 Journal article (refereed), original research -
Synthesis and In Vitro Evaluation of a Set of 6-Deoxy-6-thio-carboranyl d-Glucoconjugates Shed Light on the Substrate Specificity of the GLUT1 Transporter
Matović, Jelena; Järvinen, Juulia; Sokka, Iris K; Stockmann, Philipp; Kellert, Martin; Imlimthan, Surachet; Sarparanta, Mirkka; Johansson, Mikael P; Hey-Hawkins, Evamarie; Rautio, Jarkko; Ekholm, Filip S. 2022. ACS omega. 7: 30376-30388 A1 Journal article (refereed), original research -
Addressing the biochemical foundations of a glucose-based "Trojan horse"-stradegy to boron neutron capture therephy: from chemical synthesis to in vitro assesment
Matovic, Jelena; Järvinen, Juulia; Bland, Helena C; Sokka, Iris K; Imlimthan, Surachet; Ferrando, Ruth Mateu; Huttunen, Kristiina M; Timonen, Juri; Peräniemi, Sirpa; Aitio, Olli; Airaksinen, Anu J; Sarparanta, Mirkka; Johansson, Mikael P; Rautio, Jarkko; Ekholm, Filip S. 2020. Molecular pharmaceutics. 17: 3885-3899 A1 Journal article (refereed), original research