Prodrugs and Drug Delivery
Research group
01.01.2017 -
School of Pharmacy, Faculty of Health Sciences
Research in Prodrugs and Drug Delivery group focuses on the chemistry-based methods, especially prodrugs, to overcome drug delivery liabilities of problematic drugs and drug candidates. Much of the research is currently focusing on exploiting the body’s natural mechanisms for transporting amino acids and glucose, the LAT1 and GLUT1 proteins, respectively, for targeted drug delivery across the blood-brain barrier (BBB) and cancer cells that express these transporters.
Keywords
Doctoral Researchers
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Juulia Järvinen
Grant-funded ResearcherSchool of Pharmacy, Faculty of Health Sciences -
Katayun Bahrami
Doctoral ResearcherSchool of Pharmacy, Faculty of Health Sciences
Technicians
Other group members
Publications
4 items-
Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation
Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Bioorganic chemistry. 112: 104921 -
Addressing the biochemical foundations of a glucose-based "Trojan horse"-stradegy to boron neutron capture therephy: from chemical synthesis to in vitro assesment
Matovic, Jelena; Järvinen, Juulia; Bland, Helena C; Sokka, Iris K; Imlimthan, Surachet; Ferrando, Ruth Mateu; Huttunen, Kristiina M; Timonen, Juri; Peräniemi, Sirpa; Aitio, Olli; Airaksinen, Anu J; Sarparanta, Mirkka; Johansson, Mikael P; Rautio, Jarkko; Ekholm, Filip S. 2020. Molecular pharmaceutics. 17: 3885-3899 -
Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates
Matovic, Jelena; Järvinen, Juulia; Sokka, Iris K; Imlimthan, Surachet; Raitanen, Jan-Erik; Montaser, Ahmed; Maaheimo, Hannu; Huttunen, Kristiina M; Peräniemi, Sirpa; Airaksinen, Anu J; Sarparanta, Mirkka; Johansson, Mikael P; Rautio, Jarkko; Ekholm, Filip S. 2020. Molecular pharmaceutics. 2021; 18: 285-304 -
The expanding role of prodrugs in contemporary drug design and development
Rautio, Jarkko; Meanwell, Nicholas A; Di, Li; Hageman, Michael J. 2018. Nature reviews drug discovery. 17: 559-587