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Leaders
Levonen Lab focuses on two major research topics: cancer and metabolic diseases.
In Professor Anna-Liisa Levonen’s research group, we explore the dual role of the NRF2 transcription factor in cancer, with a particular focus on lung cancer. Additionally, we investigate metabolic diseases, emphasizing NRF2’s role in metabolic regulation and the detrimental metabolic effects of environmental toxicant exposure.
News
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New publication!
Our new article in Redox Biology: Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells -
New publication!
Our new article in Current Opinion in Chemical Biology: Electrophilic metabolites targeting the KEAP1/NRF2 partnership -
New publication!
Our recent article published in Archives of Toxicology: Metabolic effects of nuclear receptor activation in vivo after 28‑day oral exposure to… -
Levonen Lab as part of a new EU-funded project
The European Union has granted 8 million euros in funding from the Horizon Europe Programme to an international research project (NEMESIS), which…
Projects
Keywords
Leaders
Senior Researchers
Post-doctoral Researchers
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Ashik Jawahar Deen
Project ResearcherInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Henriikka Hakomäki
Postdoctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Doctoral Researchers
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Sini Pitkänen
Doctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Simone Adinolfi
Project ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Tommi Patinen
Doctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Akshatha Kalavathi Shivakumar
Doctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Jouni Härkönen
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Sreejita Das
Project ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Technicians
Students
Publications
126 items-
Electrophilic metabolites targeting the KEAP1/NRF2 partnership
Dinkova-Kostova, Albena T; Hakomäki, Henriikka; Levonen, Anna-Liisa. 2024. Current opinion in chemical biology. 78: A2 Review article, Literature review, Systematic review -
Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals
Attema, Brecht; Kummu, Outi; Pitkänen, Sini; Weisell, Jonna; Vuorio, Taina; Pennanen, Erika; Vorimo, Maria; Rysä, Jaana; Kersten, Sander; Levonen, Anna-Liisa; Hakkola, Jukka. 2024. Archives of toxicology. 98: 911-928 A1 Journal article (refereed), original research -
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
Deen, Ashik Jawahar; Adinolfi, Simone; Härkönen, Jouni; Patinen, Tommi; Liu, Xiaonan; Laitinen, Tuomo; Takabe, Piia; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna; Gawriyski, Lisa M; Arasu, Uma Thanigai; Selvarajan, Ilakya; Mäkinen, Petri; Laitinen, Hanna; Kansanen, Emilia; Kaikkonen, Minna U; Poso, Antti; Varjosalo, Markku; Levonen, Anna-Liisa. 2024. Redox biology. 69: A1 Journal article (refereed), original research -
Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer
Elomaa, Hanna; Härkönen, Jouni; Väyrynen, Sara A; Ahtiainen, Maarit; Ogino, Shuji; Nowak, Jonathan A; Lau, Mai Chan; Helminen, Olli; Wirta, Erkki Ville; Seppälä, Toni T; Böhm, Jan; Mecklin, Jukka Pekka; Kuopio, Teijo; Väyrynen, Juha P. 2024. Modern pathology. 37: . 100450 A1 Journal article (refereed), original research -
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies
Härkönen, Jouni; Pölönen, Petri; Deen, Ashik Jawahar; Selvarajan, Ilakya; Teppo, Hanna-Riikka; Dimova, Elitsa Y.; Kietzmann, Thomas; Ahtiainen, Maarit; Väyrynen, Juha P.; Väyrynen, Sara A.; Elomaa, Hanna; Tynkkynen, Niko; Eklund, Tiia; Kuopio, Teijo; Talvitie, Eva-Maria; Taimen, Pekka; Kallajoki, Markku; Kaikkonen, Minna U.; Heinäniemi, Merja; Levonen, Anna-Liisa. 2023. Redox biology. 61: A1 Journal article (refereed), original research -
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Velidendla, Bharadwaja; Niskanen, Einari; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Heikkinen, Sami. 2023. Nucleic acids research. 2024; 52: 2904-2923 A1 Journal article (refereed), original research -
PI3Kβ inhibition enhances ALK ‐inhibitor sensitivity in ALK‐rearranged lung cancer
Talwelkar, Sarang S; Mäyränpää, Mikko I; Schüler, Julia; Linnavirta, Nora; Hemmes, Annabrita; Adinolfi, Simone; Kankainen, Matti; Sommergruber, Wolfgang; Levonen, Anna‐Liisa; Räsänen, Jari; Knuuttila, Aija; Verschuren, Emmy W.; Wennerberg, Krister. 2023. Molecular oncology. 17: 747-764 A1 Journal article (refereed), original research -
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
Dufva, Olli; Gandolfi, Sara; Huuhtanen, Jani; Dashevsky, Olga; Duàn, Hanna; Saeed, Khalid; Klievink, Jay; Nygren, Petra; Bouhlal, Jonas; Lahtela, Jenni; Näätänen, Anna; Ghimire, Bishwa R.; Hannunen, Tiina; Ellonen, Pekka; Lähteenmäki, Hanna; Rumm, Pauliina; Theodoropoulos, Jason; Laajala, Essi; Härkönen, Jouni; Pölönen, Petri; Heinäniemi, Merja; Hollmén, Maija; Yamano, Shizuka; Shirasaki, Ryosuke; Barbie, David A.; Roth, Jennifer A.; Romee, Rizwan; Sheffer, Michal; Lähdesmäki, Harri; Lee, Dean A. 2023. Immunity. 56: 2816-2835.e13 A1 Journal article (refereed), original research -
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
Adinolfi, Simone; Patinen, Tommi; Jawahar Deen, Ashik; Pitkänen, Sini; Härkönen, Jouni; Kansanen, Emilia; Küblbeck, Jenni; Levonen, Anna-Liisa. 2023. Redox biology. 63: A2 Review article, Literature review, Systematic review -
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
Mehine, Miika; Ahvenainen, Terhi; Khamaiseh, Sara; Härkönen, Jouni; Reinikka, Siiri; Heikkinen, Tuomas; Äyräväinen, Anna; Pakarinen, Päivi; Härkki, Päivi; Pasanen, Annukka; Levonen, Anna-Liisa; Bützow, Ralf; Vahteristo, Pia. 2022. Oncogenesis. 11: . 52 A1 Journal article (refereed), original research