Steroid Receptor Research Center
We utilize state-of-the-art experimental and computational methods to study molecular mechanisms of steroid hormone receptor functions especially in regulation of chromatin, transcription, and treatment resistance relevant for hormone-dependent cancers, such as prostate and breast cancer.
The research groups of SRRC are led by Prof. Jorma Palvimo, Docent Leena Latonen, Docent Einari Niskanen, Academy researcher Kirsi Ketola and Ville Paakinaho, Ph.D.
The SRRC holds monthly seminar meetings.
Dates for the spring 2021 are:
Tue 23.2.
Tue 30.3.
Tue 27.4.
Wed 26.5.
Time at 2:15pm.
Group members - UEF
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Jorma Palvimo Professor , School of Medicine, Biomedicine -
Kirsi Ketola Academy Research Fellow , School of Medicine, Biomedicine -
Leena Latonen Senior Researcher , School of Medicine, Biomedicine -
Einari Niskanen University Lecturer , School of Medicine, Biomedicine -
Ville Paakinaho Postdoctoral Researcher , School of Medicine, Biomedicine
Others
Publications by the research group members
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SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites Nucleic acids research 49 4: 1951-1971. 2021
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AR and ERG drive the expression of prostate cancer specific long noncoding RNAs Kohvakka, Annika; Sattari, Mina; Shcherban, Anastasia; Annala, Matti; Urbanucci, Alfonso; Kesseli, Juha; Tammela, Teuvo L J; Kivinummi, Kati; Latonen, Leena; Nykter, Matti; Visakorpi, Tapio. 2020. AR and ERG drive the expression of prostate cancer specific long noncoding RNAs Oncogene 39 30: 5241-5251. 2020
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BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation Lempiäinen, JK; Manjur, ABMK; Malinen, M; Ketola, K; Niskanen, EA; Palvimo, JJ. 2020. BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation Oncogene 39: 2391-2407. 2020
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Histonien muokkaukset ja geenien säätely Sutinen, Siiri; Niskanen, Einari. 2020. Histonien muokkaukset ja geenien säätely SOLUBIOLOGI 1: 12-21. 2020
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Integrative proteomics of prostate cancer Scaravilli, M; Afyounian, E; Nykter, M; Visakorpi, T; Latonen, L. 2020. Integrative proteomics of prostate cancer Current opinion in endocrine and metabolic research 10: 43-49. 2020
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New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing Jaillard, Sylvie; Bell, Katrina; Akloul, Linda; Walton, Kelly; McElreavy, Kenneth; Stocker, William A; Beaumont, Marion; Harrisson, Craig; Jääskeläinen, Tiina; Palvimo, Jorma J; Robevska, Gorjana; Launay, Erika; Satié, Anne-Pascale; Listyasari, Nurin; Bendavid, Claude; Sreenivasan, Rajini; Duros, Solène; van den Bergen, Jocelyn; Henry, Catherine; Domin-Bernhard, Mathilde et al.. 2020. New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing Maturitas 141: 9-19. 2020
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Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome Paakinaho, V; Johnson, TA; Presman, DM; Hager, GL. 2019. Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome Genome research 29 8: 1223-1234. 2019
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IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling Kaiser Manjur, ABM; Lempiäinen, Joanna K; Malinen, Marjo; Palvimo, Jorma J; Niskanen, Einari A. 2019. IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling Journal of steroid biochemistry and molecular biology 192: 105382. 2019
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Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction Zhang, Fu-Ping; Malinen, Marjo; Mehmood, Arfa; Lehtiniemi, Tiina; Jääskeläinen, Tiina; Niskanen, Einari A; Korhonen, Hanna; Laiho, Asta; Elo, Laura L; Ohlsson, Claes; Kotaja, Noora; Poutanen, Matti; Sipilä, Petra; Palvimo, Jorma J. 2019. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction Nature communications 10: 777. 2019
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Meta-analysis of Chromatin Programming by Steroid Receptors Paakinaho, Ville; Swinstead, Erin E; Presman, Diego M; Grøntved, Lars; Hager, Gordon L. 2019. Meta-analysis of Chromatin Programming by Steroid Receptors Cell reports 28 13: 3523-3534. 2019