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Hani El-Nezamy

Hani El-Nezamy

Professor

Gut Health and Food Safety Research Laboratory (GHFS)

Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences

[email protected] | +358 40 591 5137

Information Publications

Research in GHFS laboratory has three focal areas:

Modulation of gut health parameters by probiotics and bioactive components in food.
Microbial therapy as an approach for management of liver diseases.
Gut microbiota in health and diseases.

Research groups

Food and Health 01.01.2012 -
Microplastic research 01.09.2016 -

Projects

Food Research and Health Connects 01.09.2022 - 31.12.2024
Direct microplastic exposure via foodstuff and food packaging - plastic leachables and their health effects (diMPex) Finished 01.09.2020 - 31.08.2024

Publications

93/93 items

Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
Lee, Pui-Kei; Co, Vanessa Anna; Yang, Yang; Wan, Murphy Lam Yim; El-Nezami, Hani; Zhao, Danyue. 2024. Food chemistry. 2025; 463: A1 Journal article (refereed), original research
Low-dose Valine Attenuates Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Mice by Enhancing Leptin Sensitivity and Modulating the Gut Microbiome
Felicianna; Kwan Lo, Emily Kwun; Chen, Congjia; Ismaiah, Marsena Jasiel; Zhang, Fangfei; Matthew Leung, Hoi Kit; El-Nezami, Hani. 2024. Molecular metabolism. 90: A1 Journal article (refereed), original research
MRGPRB2/X2 and the analogous effects of its agonist and antagonist in DSS-induced colitis in mice
Duraisamy, Karthi; Kumar, Mukesh; Nawabjan, Abdullah; Lo, Emily Kwun Kwan; hui Lin, Ming; Lefranc, Benjamin; Bonnafé, Elsa; Treilhou, Michel; El-Nezami, Hani; Leprince, Jérôme; Chow, Billy KC. 2024. Biomedicine and pharmacotherapy. 174: A1 Journal article (refereed), original research
Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds
Leung, Hoi Kit Matthew; Lo, Emily Kwun Kwan; Zhang, Fangfei; Felicianna; Ismaiah Marsena Jasiel; Chen, Congjia; El-Nezami, Hani. 2024. International journal of molecular sciences. 25: A2 Review article, Literature review, Systematic review
PNPLA3 Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids
Tauriainen, Milla-Maria; Csader, Susanne; Lankinen, Maria; Lo, Kwun Kwan; Chen, Congjia; Lahtinen, Olli; El-Nezamy, Hani; Laakso, Markku; Schwab, Ursula. 2024. Nutrients. 16: A1 Journal article (refereed), original research
Probiotic Mixture Ameliorates a Diet-Induced MASLD/MASH Murine Model through the Regulation of Hepatic Lipid Metabolism and the Gut Microbiome
Zhang, Fangfei; Lo, Emily Kwun Kwan; Chen, Jiarui; Wang, Ke; Felicianna; Ismaiah, Marsena Jasiel; Leung, Hoi Kit Matthew; Zhao, Danyue; Lee, Jetty Chung-Yung; El-Nezami, Hani. 2024. Journal of agricultural and food chemistry. 72: 8536-8549 A1 Journal article (refereed), original research
Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota
Leung, Hoi Kit Matthew; Lo, Emily Kwun Kwan; Chen, Congjia; Zhang, Fangfei; Felicianna; Ismaiah, Marsena Jasiel; El-Nezami, Hani. 2024. Probiotics and antimicrobial proteins. [Published: 06 December 2024]: 1-17 A1 Journal article (refereed), original research
Schisandrin B Suppresses Colon Cancer Growth by Inducing Cell Cycle Arrest and Apoptosis: Molecular Mechanism and Therapeutic Potential
Co, Vanessa Anna; El-Nezami, Hani; Liu, Yawen; Twum, Bonsra; Dey, Priyanka; Cox, Paul A; Joseph, Shalu; Agbodjan-Dossou, Roland; Sabzichi, Mehdi; Draheim, Roger; Wan, Murphy Lam Yim. 2024. ACS pharmacology & translational science. 7: 863-877 A1 Journal article (refereed), original research
The impact of intermittent fasting on gut microbiota: a systematic review of human studies
Paukkonen, Isa; Törrönen, Elli-Noora; Lok, Johnson; Schwab, Ursula; El-Nezami, Hani. 2024. Frontiers in nutrition. 11: 1-17 A2 Review article, Literature review, Systematic review
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice
Wang, Shuyuan; Ilves, Marit; Mäenpää, Kuunsäde; Zhao, Lan; El-Nezami, Hani; Karisola, Piia; Alenius, Harri. 2024. Acs nano. 18: 29479-29491 A1 Journal article (refereed), original research
Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression
Iannone, V; Lok, J; Babu, AF; Gómez-Gallego, C; Willman, RM; Koistinen, VM; Klåvus, A; Kettunen, MI; Kårlund, A; Schwab, U; Hanhineva, K; Kolehmainen, M; Nezami, H El. 2023. Journal of nutritional biochemistry. 115: A1 Journal article (refereed), original research
Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model
Iannone, Valeria; Babu, Ambrin Farizah; Lok, Johnson; Gómez-Gallego, Carlos; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Vaaben, Troels Holger; Bongers, Mareike; Mikkonen, Santtu; Vaittinen, Maija; Tikkanen, Ida; Kettunen, Mikko; Klåvus, Anton; Sehgal, Ratika; Kaminska, Dorota; Pihlajamaki, Jussi; Hanhineva, Kati; El-Nezami, Hani; Alexander Sommer, Morten Otto; Kolehmainen, Marjukka. 2023. Molecular metabolism. 78: A1 Journal article (refereed), original research
Editorial: Novel developments for promoting health through microbiota modulation
Gómez-Gallego, Carlos; El-Nezami, Hani. 2023. Frontiers in nutrition. 10: 1-3 B1 Non-refereed journal articles
Gut ecological networks reveal associations between bacteria, exercise, and clinical profile in non-alcoholic fatty liver disease patients
Csader, Susanne; Chen, Xiuqiang; Leung, Howell; Männistö, Ville; Pentikäinen, Heikki; Tauriainen, Milla-Maria; Savonen, Kai; El-Nezami, Hani; Schwab, Ursula; Panagiotou, Gianni. 2023. MSystems. 8: A1 Journal article (refereed), original research
Gut microbiota: Impact on 5-fluorouracil efficacy and toxicity
Lo, Emily Kwun Kwan; Leung, Hoi Kit Matthew; Zhang, Fangfei; El-Nezami, Hani. 2023. Current opinion in toxicology. 36: . 100423 A2 Review article, Literature review, Systematic review
Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches
Lo, Emily Kwun Kwan; Wang, Xiuwan; Lee, Pui-Kei; Wong, Ho-Ching; Lee, Jetty Chung-Yung; Gómez-Gallego, Carlos; Zhao, Danyue; El-Nezami, Hani; Li, Jun. 2023. Computational and Structural Biotechnology Journal. 21: 1785-1796 A1 Journal article (refereed), original research
Novel Developments for Promoting Health Through Microbiota Modulation
Gómez-Gallego, Carlos; El-Nezami, Hani. 2023. Frontiers Research Topics. . Frontiers media C2 Edited book, conference proceedings or special issue of a journal
Reduction in Five Harmful Substances in Fried Potato Chips by Pre-Soaking Treatment with Different Tea Extracts
Wang, Weitao; Wang, Huaixu; Wu, Zhongjun; Duan, Tingting; Liu, Pengzhan; Ou, Shiyi; El-Nezami, Hani; Zheng, Jie. 2023. Foods. 12: A1 Journal article (refereed), original research
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Ni, Yueqiong; Qian, Lingling; Siliceo, Sara Leal; Long, Xiaoxue; Nychas, Emmanouil; Liu, Yan; Ismaiah, Marsena Jasiel; Leung, Howell; Zhang, Lei; Gao, Qiongmei; Wu, Qian; Zhang, Ying; Jia, Xi; Liu, Shuangbo; Yuan, Rui; Zhou, Lina; Wang, Xiaolin; Li, Qi; Zhao, Yueliang; El-Nezami, Hani; Xu, Aimin; Xu, Guowang; Li, Huating; Panagiotou, Gianni; Jia, Weiping. 2023. Cell metabolism. 35: 1530-1547 A1 Journal article (refereed), original research
Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring
Virwani, Preeti Dinesh; Qian, Gordon; Hsu, Matthew SS; Pijarnvanit, Tommy KKTS; Cheung, Carman Nga-Man; Chow, Yick Hin; Tang, Lok Kan; Tse, Yiu-Hei; Xian, Jia-Wen; Lam, Shirley Sau-Wing; Lee, Crystal PI; Lo, Chelsea C.W.; Liu, Roxanna KC; Ho, Tsi Lok; Chow, Bak Yue; Leung, Kin Sum; Tsang, Hing Wai; Lo, Emily K.K.; Tung, Keith TS; Chung, Sookja Kim; Yuen, Man-Fung; Leung, Suet Yi; Ip, Patrick; Hung, Ivan Fan-Ngai; Louie, Jimmy Chun Yu; El-Nezami, Hani; Ho, Joshua Wing Kei; Lau, Kui Kai. 2023. Hypertension. 80: 1331 - 1342 A1 Journal article (refereed), original research
Twelve Weeks of High-Intensity Interval Training Alters Adipose Tissue Gene Expression but Not Oxylipin Levels in People with Non-Alcoholic Fatty Liver Disease
Csader, Susanne; Ismaiah, Marsena Jasiel; Kuningas, Tiina; Heinäniemi, Merja; Suhonen, Janne; Männistö, Ville; Pentikäinen, Heikki; Savonen, Kai; Tauriainen, Milla-Maria; Galano, Jean-Marie; Lee, Jetty Chung-Yung; Rintamäki, Reeta; Karisola, Piia; El-Nezami, Hani; Schwab, Ursula. 2023. International journal of molecular sciences. 24: A1 Journal article (refereed), original research
Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion
Leung, Hoi Kit Matthew; Lo, Emily Kwun Kwan; Chen, Congjia; Zhang, Fangfei; Felicianna; Ismaiah, Marsena Jasiel; El-Nezami, Hani. 2023. Biomedicine and pharmacotherapy. 164: A1 Journal article (refereed), original research
A New Look at the Effects of Engineered ZnO and TiO2 Nanoparticles: Evidence from Transcriptomics Studies
Wang, Shuyuan; Alenius, Harri; El-Nezami, Hani; Karisola, Piia. 2022. Nanomaterials. 12: A2 Review article, Literature review, Systematic review
Formation and metabolism of 6-(1-acetol)-8-(1-acetol)-rutin in foods and in vivo, and their cytotoxicity
Chen, Min; Liu, Pengzhan; Zhou, Hua; Huang, Caihuan; Zhai, Weiye; Xiao, Yuantao; Ou, Juanying; He, Jun; El-Nezami, Hani; Zheng, Jie. 2022. Frontiers in nutrition. 9: . 973048 A1 Journal article (refereed), original research
Gut microbiota insights into human adaption to high‐plateau diet
Huang, Yina; Liu, Jinxin; Tun, Hein Min; Stanton, Catherine; Chen, Tingtao; El‐Nezami, Hani; Wei, Hua; Wang, Mingfu; Wu, Qinglong. 2022. iMeta. 1: . e6 B1 Non-refereed journal articles
Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis
Wang, Shuyuan; Kang, Xing; Alenius, Harri; Wong, Sunny Hei; Karisola, Piia; El-Nezami, Hani. 2022. Food and chemical toxicology. 169: A1 Journal article (refereed), original research
The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood
Fong, Fiona Long Yan; El-Nezami, Hani; Mykkänen, Otto; Kirjavainen, Pirkka V.. 2022. Frontiers in nutrition. 9: . 73298 A1 Journal article (refereed), original research
The Emerging Role of Branched-Chain Amino Acids in Liver Diseases
Lo, Emily Kwun Kwan; Felicianna; Xu, Jing-Hang; Zhan, Qiao; Zeng, Zheng; El-Nezami, Hani. 2022. Biomedicines. 10: A2 Review article, Literature review, Systematic review
Theabrownin Alleviates Colorectal Tumorigenesis in Murine AOM/DSS Model via PI3K/Akt/mTOR Pathway Suppression and Gut Microbiota Modulation
Leung, Hoi Kit Matthew; Lo, Emily Kwun Kwan; El-Nezami, Hani. 2022. Antioxidants. 11: A1 Journal article (refereed), original research
Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
Xu, Jinghang; Zhan, Qiao; Fan, Yanan; Lo, Emily Kwun Kwan; Zhang, Fangfei; Yu, Yanyan; El-Nezami, Hani; Zeng, Zheng. 2021. Pathogens. 10: 782 A2 Review article, Literature review, Systematic review
Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies
Wan, Murphy Lam Yim; Co, Vanessa Anna; El-Nezami, Hani. 2021. Critical reviews in food science and nutrition. [Epub ahead of print 5 April 2021]: 1-28 A2 Review article, Literature review, Systematic review
Human immune repertoire in hepatitis B virus infection
Zhan, Qiao; Xu, Jing-Hang; Yu, Yan-Yan; Lo, Emily K N; Felicianna; El-Nezami, Hani; Zeng, Zheng. 2021. World journal of gastroenterology. 27: 3790-3801 A1 Journal article (refereed), original research
Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
Lo, Emily Kwun Kwan; Lee, Jetty Chung-Yung; Turner, Paul C; El-Nezami, Hani. 2021. Scientific reports. 11: 7403 A1 Journal article (refereed), original research
Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis
Babu, Ambrin Farizah; Csader, Susanne; Lok, Johnson; Gómez-Gallego, Carlos; Hanhineva, Kati; El-Nezami, Hani; Schwab, Ursula. 2021. Nutrients. 13: 3135 A2 Review article, Literature review, Systematic review
Yeast ß-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models
So, Sik Yu; Wu, Qinglong; Leung, Kin Sum; Kundi, Zuzanna Maria; Savidge, Tor C; El-Nezami, Hani. 2021. American journal of physiology : gastrointestinal and liver physiology. 321: G639-G655 A1 Journal article (refereed), original research
Dietary polyphenol impact on gut health and microbiota
Wan, Murphy L Y; Co, Vanessa Anna; El-Nezami, Hani. 2020. Critical reviews in food science and nutrition. 2021; 61: 690-711 A2 Review article, Literature review, Systematic review
Food ingredients in human health: Ecological and metabolic perspectives implicating gut microbiota function
Wu, Qinglong; Chen, Tingtao; El-Nezami, Hani; Savidge, Tor. 2020. Trends in food science and technology. 100: 103-117 A2 Review article, Literature review, Systematic review
Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources
Kårlund, Anna; Gómez-Gallego, Carlos; Korhonen, Jenni; Palo-Oja, Outi-Maaria; El-Nezami, Hani; Kolehmainen, Marjukka. 2020. Nutrients. 12: 1020 A2 Review article, Literature review, Systematic review
Reply to Alizadeh's letter to the editor on "Targeting bile acid metabolism in obesity reduction: A systematic review and meta-analysis"
So, Stephanie Sik Yu; Yeung, Chris Ho Ching; Schooling, C Mary; El-Nezami, Hani. 2020. Obesity reviews. 21: e13075 B1 Non-refereed journal articles
Targeting Bile Acid Metabolism in Obesity Reduction: A Systematic Review and Meta-Analysis
So, Stephanie Sik Yu; Yeung, Chris Ho Ching; Schooling, C Mary; El-Nezami, Hani. 2020. Obesity reviews. 21: e13017 A2 Review article, Literature review, Systematic review
Maternal use of drugs and preeclampsia
Sahlman, H; Koponen, M; El-Nezami, H; Vahakangas, K; Keski-Nisula, L. 2019. British journal of clinical pharmacology. 85: 2848-2855 A1 Journal article (refereed), original research
Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells
Poon, WL; Lee, JC; Leung, KS; Alenius, H; El-Nezami, H; Karisola, P. 2019. Nanotoxicology. 2020; 14: 453-467 A1 Journal article (refereed), original research
Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?
Kårlund, A; Gómez-Gallego, C; Turpeinen, AM; Palo-Oja, OM; El-Nezami, H; Kolehmainen, M. 2019. Nutrients. 11: 829 A2 Review article, Literature review, Systematic review
Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation
Wan, MLY; Turner, PC; Co, VA; Wang, MF; Amiri, KMA; El-Nezami, H. 2019. Scientific reports. 9: 19173 A1 Journal article (refereed), original research
Silver, titanium dioxide, and zinc oxide nanoparticles trigger miRNA/isomiR expression changes in THP-1 cells that are proportional to their health hazard potential
Ndika, J; Seemab, U; Poon, WL; Fortino, V; El-Nezami, H; Karisola, P; Alenius, H. 2019. Nanotoxicology. 13: 1380-1395 A1 Journal article (refereed), original research
Effects of Lactobacillus rhamnosus GG and Escherichia coli Nissle 1917 Cell-Free Supernatants on Modulation of Mucin and Cytokine Secretion on Human Intestinal Epithelial HT29-MTX Cells
Wan, Murphy Lam-Yim; Chen, Zhijian; Shah, Nagendra P; El-Nezami, Hani. 2018. Journal of food science. 83: 1999-2007 A1 Journal article (refereed), original research
Influence of functional food components on gut health
Wan, Muprhy LY; Ling, KH; El-Nezami, Hani; Wang, MF. 2018. Critical reviews in food science and nutrition. 2019; 59: 1927-1936 A2 Review article, Literature review, Systematic review
Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges
Wan, Murphy Lam Yim; Forsythe, Stephen J; El-Nezami, Hani. 2018. Critical reviews in food science and nutrition. 2019; 59: 3320-3333 A2 Review article, Literature review, Systematic review
Targeting gut microbiota in hepatocellular carcinoma: probiotics as a novel therapy
Wan, MLY; El-Nezami, H. 2018. Hepatobiliary surgery and nutrition. 7: 11-20 A2 Review article, Literature review, Systematic review
A metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in ApcMin/+ mice
Ni Y, Wong VHY, Tai WCS, Li J, Wong WY, Lee MML, Fong FLY, El-Nezami H, Panagiotou G. 2017. Journal of applied microbiology. 122: 770-784 A1 Journal article (refereed), original research
Combined Low-Dose Zearalenone and Aflatoxin B1 on Cell Growth and Cell-Cycle Progression in Breast Cancer MCF-7 Cells
Yip Ka Yiu, Wan Murphy Lam Yim, Wong Alice Sze Tsai, Korach Kenneth S, El-Nezami Hani. 2017. Toxicology letters. 281: 139-151 A1 Journal article (refereed), original research
Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells
Poon Wing-Lam, Alenius Harri, Ndika Joseph, Fortino Vittorio, Kolhinen Vesa, Mesceriakovas Arunas, Wang Mingfu, Greco Dario, Lähde Anna, Jokiniemi Jorma, Lee Jetty Chung-Yung, El-Nezami Hani, Karisola Piia. 2017. Nanotoxicology. 11: 936-951 A1 Journal article (refereed), original research
Green tea polyphenol epigallocatechin-3-gallate improves epithelial barrier function by inducing the production of antimicrobial peptide pBD-1 and pBD-2 in monolayers of porcine intestinal epithelial IPEC-J2 cells
Wan MLY, Ling KH, Wang MF, El-Nezami H. 2016. Molecular nutrition and food research. 60: 1048-1058 A1 Journal article (refereed), original research
High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE-/- mice
Chan YK, Brar MS, Kirjavainen PV, Chen Y, Peng J, Li D, Leung FC-C, El-Nezami H. 2016. Bmc microbiology. 16: 264 A1 Journal article (refereed), original research
Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors
Fong FL, Kirjavainen PV, El-Nezami H. 2016. Scientific reports. 6: 22845 A1 Journal article (refereed), original research
Lactobacillus rhamnosus GG modulates intestinal mucosal barrier and inflammation in mice following combined dietary exposure to deoxynivalenol and zearalenone
Wan Murphy LY, Turner Paul C, Allen Kevin J, El-Nezamia Hani. 2016. Journal of functional foods. 22: 34-43 A1 Journal article (refereed), original research
Modulation of Intestinal Epithelial Defense Responses by Probiotic Bacteria
Wan LYM, Chen ZJ, Shah NP, El-Nezami H. 2016. Critical reviews in food science and nutrition. 56: 2628-2641 A1 Journal article (refereed), original research
Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE-/- mice
Chan Yee Kwan, El-Nezami Hani, Chen Yan, Kinnunen Kristiina, Kirjavainen Pirkka V. 2016. Amb express. 6: 61-68 A1 Journal article (refereed), original research
Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice
Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H. 2016. Proceedings of the National Academy of Sciences of the United States of America. 113: E1306-E1315 A1 Journal article (refereed), original research
Probiotics-mediated suppression of cancer
So Stephanie S, Wan Murphy L El-Nezami Hani. 2016. Current opinion in oncology. 2017; 29: 62-72 A2 Review article, Literature review, Systematic review
Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation
Ling Ka-Ho, Lam Yim Wan Murphy, El-Nezami Hani, Wang Mingfu. 2016. Chemical research in toxicology. 29: 823-833 A1 Journal article (refereed), original research
Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors
Fong Fiona Long Yan, Kirjavainen Pirkka, Wong Victoria Ho Yee, El-Nezami Hani. 2015. Journal of functional foods. 13: 71-79 A1 Journal article (refereed), original research
Modulation of Mucin mRNA (MUC5AC and MUC5B) Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-cultures Following Exposure to Individual and Combined Fusarium Mycotoxins
Wan L-YM, Allen KJ, Turner PC, El-Nezami H. 2014. Toxicological sciences. Epub ahead of print: - A1 Journal article (refereed), original research
Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol, nivalenol, zearalenone and fumonisins B1) on swine jejunal epithelial cells
Wan LYM, Turner PC, El-Nezami H. 2013. Food and chemical toxicology. 57: 276-283 A1 Journal article (refereed), original research
Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells
Wan L-YM, Woo C-SJ, Turner PC, Wan JM-F, El-Nezami H. 2013. Toxicology letters. 220: 238-246 A1 Journal article (refereed), original research
Modulation of Porcine &#946 -Defensins 1 and 2 upon Individual and Combined Fusarium Toxin Exposure in a Swine Jejunal Epithelial Cell Line
Wan, ML-Y, Woo C-SJ, Allen KJ, Turner PC, El-Nezami H. 2013. Applied and environmental microbiology. 79: 2225-2232 A1 Journal article (refereed), original research
Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women
Piekkola S, Turner PC, Abdel-Hamid M, Ezzat S, El-Daly M, El-Kafrawy S, Savchenko E, Poussa T, Woo JCS, Mykkänen H, El-Nezami H. 2012. Food additives and contaminants part a: chemistry analysis control exposureand risk assessment. 29: 962-971 A1 Journal article (refereed), original research
Salvianolic acid B modulates the expression of drug-metabolizing enzymes in HepG2 cells
Wang QL, Wu Q, Tao YY, Liu CH, El-Nezami H. 2011. Hepatobiliary and pancreatic diseases international. 10: 502-508 A1 Journal article (refereed), original research
Probiotics and gut health: a special focus on liver diseases
Wilson Gratz S, Mykkanen H, El-Nezami HS.. 2010. World journal of gastroenterology. 16: 403-410 A1 Journal article (refereed), original research
Combining strains of lactic acid bacteria may reduce their toxin and heavy metal removal efficiency from aqueous solution
Halttunen T, Collado MC, El-Nezami H, Mesiluoto J, Salminen S, El-Nezami H. 2008. Letters in applied microbiology. 46: 160-165 A1 Journal article (refereed), original research
Lactobacillus rhamnosus strain GG resores alkaline phosphatase activity in differentiating Caco-2 cells dosed with the potent mycotoxin deoxynivalenol
Turner PC, Wu QK, Piekkola S, Gratz S, Mykkänen H, El-Nezami H, Piekkola S, Mykkänen H, El-Nezami H. 2008. Food and chemical toxicology. 46: 2118-2123 A1 Journal article (refereed), original research
The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon
Hatakka K, Holma R, El-Nezami H, Suomalainen T, Kuisma M, Saxelin M, Poussa T, Mykkänen H, Korpela R. 2008. International journal of food microbiology. 128: 406-410 A2 Review article, Literature review, Systematic review
Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea
Polychronaki N, Wild CP, Mykkänen H, Amra H, Abdel-Wahhab M, Sylla A, Diallo M, El-Nezami H, Turner PC, Polychronaki N, El-Nezami H. 2008. Food and chemical toxicology. 46: 519-526 A1 Journal article (refereed), original research
A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers
Polychronaki N, West RM, Turner PC, Amra H, Abdel-Wahhab M, Mykkänen H, El-Nezami H, Polychronaki N, El-Nezami H. 2007. Food and chemical toxicology. 45: 1210-1215 A1 Journal article (refereed), original research
High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota
Gråsten SM, Juntunen KS, Mättö J, Mykkänen OT, El-Nezami H, Adlercreutz H, Poutanen KS, Mykkänen HM, Mykkänen OT, El-Nezami H, Poutanen KS. 2007. Nutrition research. 27: 454-461 A1 Journal article (refereed), original research
Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 cells
Gratz S, Wu QK, El-Nezami H, Juvonen RO, Mykkänen H, Turner PC, Gratz S, WU QK, El-Nezami H. 2007. Applied and environmental microbiology. 73: 3958-3964 A1 Journal article (refereed), original research
Cadmium and lead elimination in young male chinese students. A probiotic intervention study
Ibrahim F, Salminen S, Mykkänen H, El-Nezami H, Salminen E, Ma J, Ling WH, Benno Y, Tahvonen R. 2006. NUTRAFOODS. 5: 5-9 A1 Journal article (refereed), original research
Determinants of aflatoxin M1 in breast milk in a selected group of Egyptian mothers
Polychronaki N, Turner PC, Mykkänen H, Gong Y, Amra H, Abdel-Wahhab M, El-Nezami H, Polychronaki N, El-Nezami H. 2006. Food additives and contaminants. 23: 700-708 A1 Journal article (refereed), original research
Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B1 in rats
Gratz S, Täubel M, Juvonen RO, Viluksela M, Turner PC, Mykkänen H, El-Nezami H, Gratz S, Täubel M, El-Nezami H. 2006. Applied and environmental microbiology. 72: 7398-7400 A1 Journal article (refereed), original research
Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China
El-Nezami HS, Polychronaki NN, Ma J, Zhu H, Ling W, Salminen EK, Juvonen RO, Salminen SJ, Poussa T, Mykkänen HM, El-Nezami HS, Polychronaki NN, Mykkänen HM. 2006. American journal of clinical nutrition. 83: 1199-1203 A1 Journal article (refereed), original research
Aflatoxin B1 binding by a mixture of lactobacillus and propionibacterium: in vitro versus ex vivo
Gratz S, Mykkänen H, El-Nezami H, Gratz S, El-Nezami H. 2005. Journal of food protection. 68: 2470-2474 A1 Journal article (refereed), original research
Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males
Mykkänen H, Zhu H, Salminen E, Juvonen RO, Ling W, Ma J, Polychronaki N, Kemiläinen H, Mykkänen O, Salminen S, El-Nezami H, Mykkänen H, Polychronaki, Kemiläinen H, Mykkänen O, El-Nezami H. 2005. International journal of cancer. 115: 879-884 A1 Journal article (refereed), original research
Probiotics: Synenergy with drugs and carcinogens in diet
Salminen S, El-Nezami H, Salminen E, Mykkänen H. Teoksessa: Thompson LU, Ward WE(toim.) , 2005. Food-Drug Synergy and Safety. s. 219-232. Taylor & Francis A3 Book section, Chapters in research books
Chemical moieties and interactions involved in the binding of zearalenone to the surface of lactobacillus rhamnosus strains GG
El-Nezami H, Polychronaki N, Lee YK, Haskard C, Juvonen R, Salminen S, Mykkänen H, El-Nezami H. 2004. Journal of agricultural and food chemistry. 52: 4577-4581 A1 Journal article (refereed), original research
Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro
Gratz S, Mykkänen H, Ouwehand AC, Juvonen R, Salminen S, El-Nezami H, Gratz S, El-Nezami H. 2004. Applied and environmental microbiology. 70: 6306-6308 A1 Journal article (refereed), original research
Lactic acid bacteria as a tool for enhancing food safety by removal of dietary toxins
El-Nezami HS, Salminen S, Salminen E, Mykkänen H. Teoksessa: Salminen S; von Wright A; Ouwehand A(toim.) , 2004. Lactic acid bacteria:Microbiology and functional aspects. s. 397-406. Marcel Deccer,Inc. A3 Book section, Chapters in research books
Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans
Gråsten S, Liukkonen K-H, Chrevatidis A, El-Nezami H, Poutanen K, Mykkänen H. 2003. Nutrition research. 23: 1503-1514 A1 Journal article (refereed), original research
Kinetics of adsorption and desorption of alfatoxin B1 by viable and nonviable bacteria
Lee YK, El-Nezami H, Haskard CA, Gratz S, Puong KY, Salminen S, Mykkänen H. 2003. Journal of food protection. 66: 426-430 A1 Journal article (refereed), original research
Binding rather than metabolism may explain the interaction of two food-grade lactobacillus strains with zearalenone and its derivative alfa-zearalenol
El-Nezami H, Polychronaki N, Salminen S, Mykkänen H. 2002. Applied and environmental microbiology. 68: 3545-3549 A1 Journal article (refereed), original research
Probiotic bacteria-mycotoxins interactopns: an approach to enhance food safety
El-Nezami H, Salminen S, Mykkänen H. 2002. Polish journal of food and nutrition sciences. 11: 39-43 A1 Journal article (refereed), original research
Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium
El-Nezami HS, Chrevatidis A, Auriola S, Salminen S, Mykkänen H. 2002. Food additives and contaminants. 19: 680-686 A1 Journal article (refereed), original research
Ability of a mixture of lactobacillus and propionibacterium to influence the faecal aflatoxin content in healthy egyptian volunteers: A pilot clinical study
El-Nezami H, Mykkänen H, Kankaanpää P, Suomalainen T, Salminen S, Ahokas J. 2000. BIOSCIENCE MICROFLORA. 19: 41-45 A1 Journal article (refereed), original research
Ability of lactobacillus and propionibacterium strains to remove aflatoxin B1 from the chicken duodenum
El-Nezami H, Mykkänen H, Kankaanpää P, Salminen S, Ahokas J. 2000. Journal of food protection. 63: 549-552 A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Hani El-Nezamy

Modulation of gut health parameters by probiotics and bioactive components in food.

Microbial therapy as an approach for management of liver diseases.

Gut microbiota in health and diseases.

Research groups

Projects

Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer

Low-dose Valine Attenuates Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Mice by Enhancing Leptin Sensitivity and Modulating the Gut Microbiome

MRGPRB2/X2 and the analogous effects of its agonist and antagonist in DSS-induced colitis in mice

Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds

PNPLA3 Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids

Probiotic Mixture Ameliorates a Diet-Induced MASLD/MASH Murine Model through the Regulation of Hepatic Lipid Metabolism and the Gut Microbiome

Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota

Schisandrin B Suppresses Colon Cancer Growth by Inducing Cell Cycle Arrest and Apoptosis: Molecular Mechanism and Therapeutic Potential

The impact of intermittent fasting on gut microbiota: a systematic review of human studies

ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice

Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Editorial: Novel developments for promoting health through microbiota modulation

Gut ecological networks reveal associations between bacteria, exercise, and clinical profile in non-alcoholic fatty liver disease patients

Gut microbiota: Impact on 5-fluorouracil efficacy and toxicity

Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

Novel Developments for Promoting Health Through Microbiota Modulation

Reduction in Five Harmful Substances in Fried Potato Chips by Pre-Soaking Treatment with Different Tea Extracts

Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations

Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring

Twelve Weeks of High-Intensity Interval Training Alters Adipose Tissue Gene Expression but Not Oxylipin Levels in People with Non-Alcoholic Fatty Liver Disease

Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion

A New Look at the Effects of Engineered ZnO and TiO2 Nanoparticles: Evidence from Transcriptomics Studies

Formation and metabolism of 6-(1-acetol)-8-(1-acetol)-rutin in foods and in vivo, and their cytotoxicity

Gut microbiota insights into human adaption to high‐plateau diet

Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis

The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood

The Emerging Role of Branched-Chain Amino Acids in Liver Diseases

Theabrownin Alleviates Colorectal Tumorigenesis in Murine AOM/DSS Model via PI3K/Akt/mTOR Pathway Suppression and Gut Microbiota Modulation

Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management

Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies

Human immune repertoire in hepatitis B virus infection

Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis

Yeast ß-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models

Dietary polyphenol impact on gut health and microbiota

Food ingredients in human health: Ecological and metabolic perspectives implicating gut microbiota function

Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources

Reply to Alizadeh's letter to the editor on "Targeting bile acid metabolism in obesity reduction: A systematic review and meta-analysis"

Targeting Bile Acid Metabolism in Obesity Reduction: A Systematic Review and Meta-Analysis

Maternal use of drugs and preeclampsia

Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation

Silver, titanium dioxide, and zinc oxide nanoparticles trigger miRNA/isomiR expression changes in THP-1 cells that are proportional to their health hazard potential

Effects of Lactobacillus rhamnosus GG and Escherichia coli Nissle 1917 Cell-Free Supernatants on Modulation of Mucin and Cytokine Secretion on Human Intestinal Epithelial HT29-MTX Cells

Influence of functional food components on gut health

Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges

Targeting gut microbiota in hepatocellular carcinoma: probiotics as a novel therapy

A metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in ApcMin/+ mice

Combined Low-Dose Zearalenone and Aflatoxin B1 on Cell Growth and Cell-Cycle Progression in Breast Cancer MCF-7 Cells

Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells

Green tea polyphenol epigallocatechin-3-gallate improves epithelial barrier function by inducing the production of antimicrobial peptide pBD-1 and pBD-2 in monolayers of porcine intestinal epithelial IPEC-J2 cells

High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE-/- mice

Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors

Lactobacillus rhamnosus GG modulates intestinal mucosal barrier and inflammation in mice following combined dietary exposure to deoxynivalenol and zearalenone

Modulation of Intestinal Epithelial Defense Responses by Probiotic Bacteria

Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE-/- mice

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

Probiotics-mediated suppression of cancer

Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation

Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors

Modulation of Mucin mRNA (MUC5AC and MUC5B) Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-cultures Following Exposure to Individual and Combined Fusarium Mycotoxins

Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol, nivalenol, zearalenone and fumonisins B1) on swine jejunal epithelial cells

Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells

Modulation of Porcine &#946 -Defensins 1 and 2 upon Individual and Combined Fusarium Toxin Exposure in a Swine Jejunal Epithelial Cell Line

Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women

Salvianolic acid B modulates the expression of drug-metabolizing enzymes in HepG2 cells

Probiotics and gut health: a special focus on liver diseases

Combining strains of lactic acid bacteria may reduce their toxin and heavy metal removal efficiency from aqueous solution

Lactobacillus rhamnosus strain GG resores alkaline phosphatase activity in differentiating Caco-2 cells dosed with the potent mycotoxin deoxynivalenol

The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon

Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea