Henna Martiskainen
Academy Research Fellow
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
My research is focused on the genetic risk factors for Alzheimer’s disease and other neurodegenerative diseases in the Finnish population. I use human-derived cell models to understand the molecular mechanisms of the genetic risk variants in microglial cells.
Research groups
Publications
24/24 items-
Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals
Koivumäki, Mikko; Martiskainen, Henna; Takalo, Mari; Lehtisalo, Jenni; Ngandu, Tiia; Snellman, Anniina; Hiltunen, Mikko; Rinne, Juha O, 2026, Alzheimer's research and therapy, 18, 67. A1 Journal article (refereed), original research -
Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models
Hoffmann, Dorit; Ahola, Virpi; Huber, Nadine; Natunen, Teemu; Leskelä, Stina; Takalo, Mari; Martiskainen, Henna; Ballweg, Stephanie; Vorontsov, Egor; Selzer, Stefan; Kallio, Pekka; Pike, Ian; Sirviö, Jouni; Haapasalo, Annakaisa; Hiltunen, Mikko, 2026, Biomedicine and pharmacotherapy, 198, 119347. A1 Journal article (refereed), original research -
Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers
Jeskanen, Heli; Heikkinen, Sami; Kervinen, Inka; Lehtisalo, Jenni; Ngandu, Tiia; Willman, Roosa-Maria; Rosa, Jessica; Hoffmann, Dorit; Leinonen, Ville; Haapasalo, Annakaisa; Takalo, Mari; Martiskainen, Henna; Hiltunen, Mikko, 2026, Alzheimer's research and therapy, 18, 1, 53. A1 Journal article (refereed), original research -
Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse
Kemppainen, S; Aramburu-Núñez, M; Koivisto, H; Posado-Fernández, A; Felix-Garcia, MR; Nurminen, K; Häkli, S; Abelli-Deulofeu, E; Kaisto, M; Custodia, A; van Olst, L; Willman, R-M; Mäkinen, P; Miettinen, PO; Schouten, M; Iglesias-Rey, Ramón; Kamermans, A; Martiskainen, H; Rauramaa, T; de Vries, HE; Eng, E; Salo, R; Kettunen, M; Gröhn, O; Gureviciene, I; Chmielevski, P; Ouro, A; Lapresa, R; Agulla, J; Almeida, A; Doria, G; Flores, O; Aguiar, P; Carmans, S; Roucourt, B; Hiltunen, M; Sobrino, T; Tan, 2025, Experimental neurology, 391, 115315. A1 Journal article (refereed), original research -
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha, 2025, Fluids and barriers of the cns, 22, 1, 17. A1 Journal article (refereed), original research -
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C, 2025, Molecular neurodegeneration, 20, 1, 50. A1 Journal article (refereed), original research -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research -
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome
Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna, 2024, Journal of neuropathology and experimental neurology, 83, 11, 967-978. A1 Journal article (refereed), original research -
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko, 2023, Cells, 12, 10, 1422. A1 Journal article (refereed), original research -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo,, 2023, Neurobiology of disease, 182, 106140. A1 Journal article (refereed), original research