Hennariikka Koivisto

Altered behaviour and immune response in mice with NHLRC2 p. Asp148Tyr variant

Hiltunen, Anniina E; Kangas, Salla M; Gondane, Aishwarya; Koivisto, Henna; Salokas, Kari; Heikkinen, Anne; Salo, Miia H; Roning, Tapio; Tallgren, Antti; Glumoff, Virpi; Denis, Maria C; Karagianni, Niki; Myllyharju, Johanna; Varjosalo, Markku; Tanila, Heikki; Itkonen, Harri M; Ramet, Mika; Uusimaa, Johanna; Hinttala, Reetta, 2025, Brain, behavior, & immunity : health, 46, 101020. A1 Journal article (refereed), original research

Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse

Kemppainen, S; Aramburu-Núñez, M; Koivisto, H; Posado-Fernández, A; Felix-Garcia, MR; Nurminen, K; Häkli, S; Abelli-Deulofeu, E; Kaisto, M; Custodia, A; van Olst, L; Willman, R-M; Mäkinen, P; Miettinen, PO; Schouten, M; Iglesias-Rey, Ramón; Kamermans, A; Martiskainen, H; Rauramaa, T; de Vries, HE; Eng, E; Salo, R; Kettunen, M; Gröhn, O; Gureviciene, I; Chmielevski, P; Ouro, A; Lapresa, R; Agulla, J; Almeida, A; Doria, G; Flores, O; Aguiar, P; Carmans, S; Roucourt, B; Hiltunen, M; Sobrino, T; Tan, 2025, Experimental neurology, 391, 115315. A1 Journal article (refereed), original research

Novel object recognition task for mice: is it a test for memory, object neophobia or innate preference?

Koivisto, H; Maguire, C; Tanila, H, 2025, Behavioural brain research, 491, 115649. A1 Journal article (refereed), original research

Targeting HIF-P4H-2 in APP/PS1 Alzheimer’s mouse model improves glucose metabolism, reduces dystrophic neurites and maintains exploratory activity

Kurkela, Margareta; Dvořáková, Lenka; Koivisto, Henna; Uusitalo, Maiju; Kursula, Petri; Kettunen, Mikko; Gröhn, Olli; Tanila, Heikki; Koivunen, Peppi, 2025, Journal of biological chemistry, 301, 8, 110432. A1 Journal article (refereed), original research

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research

Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model

Autio, Kaija J; Koivisto, Hennariikka; Schmitz, Werner; Puronurmi, Anna; Tanila, Heikki; Kastaniotis, Alexander J, 2024, Journal of nutritional biochemistry, 131, 109692. A1 Journal article (refereed), original research

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari, 2024, Nature cardiovascular research, 3, 4, 474-491. A1 Journal article (refereed), original research

Activation of the hypoxia response protects mice from amyloid-β accumulation

Ollonen, Teemu; Kurkela, Margareta; Laitakari, Anna; Sakko, Samuli; Koivisto, Henna; Myllyharju, Johanna; Tanila, Heikki; Serpi, Raisa; Koivunen, Peppi, 2022, Cellular and molecular life sciences, 79, 8, 432. A1 Journal article (refereed), original research

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia, 2022, Cells, 11, 24, 4116. A1 Journal article (refereed), original research

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Virenque, Anaïs; Koivisto, Hennariikka; Antila, Salli; Zub, Emma; Rooney, Erin Jane; Miszczuk, Diana; Müller, Adrian; Stoka, Enija; Marchi, Nicola; Alitalo, Kari; Tanila, Heikki; Noe, Francesco Mattia, 2022, Brain, behavior, & immunity : health, 23, 100466. A1 Journal article (refereed), original research

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Koskuvi, Marja; Lehtonen, ¦árka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Tohka, Jussi; Giniatullin, Rashid; Rivera, Claudio; Hovatta, Iiris; Tanila, Heikki; Tiihonen, Jari; Koi, 2021, Glia, 2022; 70, 4, 650-660. A1 Journal article (refereed), original research

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli, 2021, Neuroimage, 234, 117987. A1 Journal article (refereed), original research

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Mett, Janine; Lauer, Anna A; Janitschke, Daniel; Griebsch, Lea V; Theiss, Elena L; Grimm, Heike S; Koivisto, Hennariikka; Tanila, Heikki; Hartmann, Tobias; Grimm, Marcus OW, 2021, Cells, 10, 11, 2941. A1 Journal article (refereed), original research

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M, 2020, Journal of neuroinflammation, 17, 1, 271. A1 Journal article (refereed), original research

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko], 2020, Molecular neurodegeneration, 15, 66. A1 Journal article (refereed), original research

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A, 2019, Epilepsy research, 151, 67-74. A1 Journal article (refereed), original research

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

Leinonen, H; Koivisto, H; Lipponen, HR; Matilainen, A; Salo, AM; Dimova, EY; Hämäläinen, E; Stavén, S; Miettinen, P; Myllyharju, J; Koivunen, P; Tanila, H, 2019, Neuropharmacology, 153, 63-72. A1 Journal article (refereed), original research

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Koivisto, H; Ytebrouck, E; Carmans, S; Naderi, R; Miettinen, PO; Roucourt, B; Tanila, H, 2019, Behavioural brain research, 376, 112158. A1 Journal article (refereed), original research

Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

Zainul, Z; Heikkinen, A; Koivisto, H; Rautalahti, I; Kallio, M; Lin, S; Härönen, H; Norman, O; Rüegg, MA; Tanila, H; Pihlajaniemi, T, 2018, Journal of neuroscience, 38, 17, 4243-4258. A1 Journal article (refereed), original research

Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Herrala, Mikko; Kumari, Kajal; Koivisto, Hennariikka; Luukkonen, Jukka; Tanila, Heikki; Naarala, Jonne; Juutilainen, Jukka, 2018, Environmental research, 167, 759-769. A1 Journal article (refereed), original research

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Nair, Remya R; Koivisto, Henna; Jokivarsi, Kimmo; Miinalainen, Ilkka J; Autio, Kaija J; Manninen, Aki; Poutiainen, Pekka; Tanila, Heikki; Hiltunen, J Kalervo; Kastaniotis, Alexander J, 2018, Journal of neuroscience, 38, 45, 9781-9800. A1 Journal article (refereed), original research

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki, 2018, Neurobiology of aging, 71, 127-141. A1 Journal article (refereed), original research

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M, 2018, Neurobiology of aging, 2019; 75, 98-108. A1 Journal article (refereed), original research

Assessment of Health Risks of Intermediate Frequency Magnetic Fields

Herrala M, Kumari K, Blomme A, Khan MW, Koivisto H, Naarala J, Roivainen P, Tanila H, Viluksela M, Juutilainen J, 2017, Eskola Hannu, Väisänen Outi, Viik Jari, Hyttinen Jari, Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017, 719-722. A3 Book section, Chapters in research books

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J, 2017, PLoS ONE, 12, 12, e0188880. A1 Journal article (refereed), original research

Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields

Kumari, Kajal; Koivisto, Hennariikka; Myles, Capstick; Naarala, Jonne; Viluksela, Matti; Tanila, Heikki; Juutilainen, Jukka, 2017, Environmental research, 2018; 162, 27-34. A1 Journal article (refereed), original research

Effects of intermediate frequency magnetic fields on male fertility indicators in mice

Kumari K, Capstick M, Cassara AM, Herrala M, Koivisto H, Naarala J, Tanila H, Viluksela M, Juutilainen J, 2017, Environmental research, 157, 64-70. A1 Journal article (refereed), original research

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

Koivisto H, Leinonen H, Puurula M, Hafez HS, Barrera GA, Stridh MH, Waagepetersen HS, Tiainen M, Soininen P, Zilberter Y, Tanila H., 2016, Frontiers in aging neuroscience, 8, 1-14. A1 Journal article (refereed), original research

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Kemppainen Susanna, Lindholm Päivi, Galli Emilia, Lahtinen Hanna-Maija, Koivisto Henna, Hämäläinen Elina, Saarma Mart, Taanila Heikki, 2015, Behavioural brain research, 291, 1-11. A1 Journal article (refereed), original research

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice

Janickova H, Rudajev V, Dolejsi E, Koivisto H, Jakubik J, Tanila H, El-Fakahany EE, Dolezal V, 2015, Current alzheimer research, 12, 10, 923-931. A1 Journal article (refereed), original research

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M, 2014, Journal of nutritional biochemistry, 25, 6, 634-641. A1 Journal article (refereed), original research

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H, 2014, Journal of nutritional biochemistry, 25, 2, 157-169. A1 Journal article (refereed), original research

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E, 2013, PLoS ONE, 2013 Jul 3;8(7): e68722. A1 Journal article (refereed), original research

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Vepsäläinen Saila, Koivisto Henna, Pekkarinen Elina, Mäkinen Petra, Dobson Gary, McDougall Gordon J, Stewart Derek, Haapasalo Annakaisa, Karjalainen Reijo O, Tanila Heikki, Hiltunen Mikko, 2012, Journal of nutritional biochemistry, 24, 360-370. A1 Journal article (refereed), original research

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H, 2012, Journal of cellular and molecular medicine, 16, 1206-1222. A1 Journal article (refereed), original research

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

Machová E, Rudajev V, Smycková H, Koivisto H, Tanila H & Dolezal V, 2010, Neurobiology of disease, 38, 27-35. A1 Journal article (refereed), original research

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H, 2008, Journal of neurochemistry, 105, 584-594. A1 Journal article (refereed), original research

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

Machová E, Jakubík J, Michal P, Oksman M, Iivonen H, Tanila H, Dolezal V, 2008, Neurobiology of aging, 29, 3, 368-378. A1 Journal article (refereed), original research

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J, 2007, Journal of neuroscience, 27, 14, 3712-3721. A1 Journal article (refereed), original research

Hypothermia in mice tested in Morris water maze

Iivonen H, Nurminen L, Harri M, Tanila H, Puoliväli J, 2003, Behavioural brain research, 141, 207-213. A1 Journal article (refereed), original research

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Hennariikka Koivisto

Research groups

Altered behaviour and immune response in mice with NHLRC2 p. Asp148Tyr variant

Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse

Novel object recognition task for mice: is it a test for memory, object neophobia or innate preference?

Targeting HIF-P4H-2 in APP/PS1 Alzheimer’s mouse model improves glucose metabolism, reduces dystrophic neurites and maintains exploratory activity

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Activation of the hypoxia response protects mice from amyloid-β accumulation

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Assessment of Health Risks of Intermediate Frequency Magnetic Fields

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields

Effects of intermediate frequency magnetic fields on male fertility indicators in mice

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Hypothermia in mice tested in Morris water maze