Hennariikka Koivisto

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha. 2025. Journal of neuroinflammation. 22: . 64 A1 Journal article (refereed), original research

Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model

Autio, Kaija J; Koivisto, Hennariikka; Schmitz, Werner; Puronurmi, Anna; Tanila, Heikki; Kastaniotis, Alexander J. 2024. Journal of nutritional biochemistry. 131: A1 Journal article (refereed), original research

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari. 2024. Nature cardiovascular research. 3: 474-491 A1 Journal article (refereed), original research

Activation of the hypoxia response protects mice from amyloid-β accumulation

Ollonen, Teemu; Kurkela, Margareta; Laitakari, Anna; Sakko, Samuli; Koivisto, Henna; Myllyharju, Johanna; Tanila, Heikki; Serpi, Raisa; Koivunen, Peppi. 2022. Cellular and molecular life sciences. 79: . 432 A1 Journal article (refereed), original research

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia. 2022. Cells. 11: A1 Journal article (refereed), original research

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Virenque, Anaïs; Koivisto, Hennariikka; Antila, Salli; Zub, Emma; Rooney, Erin Jane; Miszczuk, Diana; Müller, Adrian; Stoka, Enija; Marchi, Nicola; Alitalo, Kari; Tanila, Heikki; Noe, Francesco Mattia. 2022. Brain, behavior, & immunity : health. 23: A1 Journal article (refereed), original research

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Koskuvi, Marja; Lehtonen, ¦árka; Trontti, Kalevi; Keuters, Meike; Wu, Ying-Chieh; Koivisto, Hennariikka; Ludwig, Anastasia; Plotnikova, Lidiia; Virtanen, Pekka LJ; Räsänen, Noora; Kaipainen, Satu; Hyötyläinen, Ida; Dhungana, Hiramani; Giniatullina, Raisa; Ojansuu, Ilkka; Vaurio, Olli; Cannon, Tyrone D; Lönnqvist, Jouko; Therman, Sebastian; Suvisaari, Jaana; Kaprio, Jaakko; Lähteenvuo, Markku; Tohka, Jussi; Giniatullin, Rashid; Rivera, Claudio; Hovatta, Iiris; Tanila, Heikki; Tiihonen, Jari; Koi. 2021. Glia

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Neuroimage

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Mett, Janine; Lauer, Anna A; Janitschke, Daniel; Griebsch, Lea V; Theiss, Elena L; Grimm, Heike S; Koivisto, Hennariikka; Tanila, Heikki; Hartmann, Tobias; Grimm, Marcus OW. 2021. Cells

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Epilepsy research

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

Leinonen, H; Koivisto, H; Lipponen, HR; Matilainen, A; Salo, AM; Dimova, EY; Hämäläinen, E; Stavén, S; Miettinen, P; Myllyharju, J; Koivunen, P; Tanila, H. 2019. Neuropharmacology

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Koivisto, H; Ytebrouck, E; Carmans, S; Naderi, R; Miettinen, PO; Roucourt, B; Tanila, H. 2019. Behavioural brain research

Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

Zainul, Z; Heikkinen, A; Koivisto, H; Rautalahti, I; Kallio, M; Lin, S; Härönen, H; Norman, O; Rüegg, MA; Tanila, H; Pihlajaniemi, T. 2018. Journal of neuroscience

Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Herrala, Mikko; Kumari, Kajal; Koivisto, Hennariikka; Luukkonen, Jukka; Tanila, Heikki; Naarala, Jonne; Juutilainen, Jukka. 2018. Environmental research

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Nair, Remya R; Koivisto, Henna; Jokivarsi, Kimmo; Miinalainen, Ilkka J; Autio, Kaija J; Manninen, Aki; Poutiainen, Pekka; Tanila, Heikki; Hiltunen, J Kalervo; Kastaniotis, Alexander J. 2018. Journal of neuroscience

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki. 2018. Neurobiology of aging

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Neurobiology of aging

Assessment of Health Risks of Intermediate Frequency Magnetic Fields

Herrala M, Kumari K, Blomme A, Khan MW, Koivisto H, Naarala J, Roivainen P, Tanila H, Viluksela M, Juutilainen J. 2017. IFMBE proceedings

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J. 2017. PLoS ONE

Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields

Kumari, Kajal; Koivisto, Hennariikka; Myles, Capstick; Naarala, Jonne; Viluksela, Matti; Tanila, Heikki; Juutilainen, Jukka. 2017. Environmental research

Effects of intermediate frequency magnetic fields on male fertility indicators in mice

Kumari K, Capstick M, Cassara AM, Herrala M, Koivisto H, Naarala J, Tanila H, Viluksela M, Juutilainen J. 2017. Environmental research

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

Koivisto H, Leinonen H, Puurula M, Hafez HS, Barrera GA, Stridh MH, Waagepetersen HS, Tiainen M, Soininen P, Zilberter Y, Tanila H.. 2016. Frontiers in aging neuroscience

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Kemppainen Susanna, Lindholm Päivi, Galli Emilia, Lahtinen Hanna-Maija, Koivisto Henna, Hämäläinen Elina, Saarma Mart, Taanila Heikki. 2015. Behavioural brain research

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice

Janickova H, Rudajev V, Dolejsi E, Koivisto H, Jakubik J, Tanila H, El-Fakahany EE, Dolezal V. 2015. Current alzheimer research

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H. 2014. Journal of nutritional biochemistry

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. 2013. PLoS ONE

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Vepsäläinen Saila, Koivisto Henna, Pekkarinen Elina, Mäkinen Petra, Dobson Gary, McDougall Gordon J, Stewart Derek, Haapasalo Annakaisa, Karjalainen Reijo O, Tanila Heikki, Hiltunen Mikko. 2012. Journal of nutritional biochemistry

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Journal of cellular and molecular medicine

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

Machová E, Rudajev V, Smycková H, Koivisto H, Tanila H & Dolezal V. 2010. Neurobiology of disease

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H. 2008. Journal of neurochemistry

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

Machová E, Jakubík J, Michal P, Oksman M, Iivonen H, Tanila H, Dolezal V. 2008. Neurobiology of aging

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience

Hypothermia in mice tested in Morris water maze

Iivonen H, Nurminen L, Harri M, Tanila H, Puoliväli J. 2003. Behavioural brain research

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Hennariikka Koivisto

Research groups

Publications

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Activation of the hypoxia response protects mice from amyloid-β accumulation

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Isoflurane affects brain functional connectivity in rats 1 month after exposure

Medium-Chain Length Fatty Acids Enhance Aß Degradation by Affecting Insulin-Degrading Enzyme

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Assessment of Health Risks of Intermediate Frequency Magnetic Fields

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields

Effects of intermediate frequency magnetic fields on male fertility indicators in mice

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Hypothermia in mice tested in Morris water maze