Ina Pöhner
Postdoctoral Researcher
School of Pharmacy, Faculty of Health Sciences
ina.pohner@uef.fi | +358 50 320 6042
Early during my scientific career, I focused on studying protein-protein interactions by computational methods. During my PhD, I shifted my focus to protein-small molecule interactions and their modulation in the context of computer-aided drug design for neglected tropical diseases. As a passionate Linux-user and administrator, I moved on to dive into aspects of databases, data management and FAIR data (data that is Findable, Accessible, Interoperable, and Reusable).
My postdoctoral research at UEF finally connects all my expertise in data-intensive drug discovery projects, dedicated to anti-viral, anti-bacterial and anti-protozoal research. My projects involve, for example, semi-automated docking studies of several hundreds of targets and billion-scale virtual screening, where I utilize powerful combinations of computer-aided drug discovery and modeling techniques, programming, databases and machine-learning – and all that – naturally – penguin-powered.
Research groups
Publications
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Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome
Bogacheva, Mariia S; Kuivanen, Suvi; Potdar, Swapnil; Hassinen, Antti; Huuskonen, Sini; Pöhner, Ina; Luck, Tamara J; Turunen, Laura; Feodoroff, Michaela; Szirovicza, Leonora; Savijoki, Kirsi; Saarela, Jani; Tammela, Päivi; Paavolainen, Lassi; Poso, Antti; Varjosalo, Markku; Kallioniemi, Olli; Pietiäinen, Vilja; Vapalahti, Olli. 2024. Antiviral research. 223: A1 Journal article (refereed), original research -
Design, synthesis and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
Roussaki, Marina; Magoulas, George E; Fotopoulou, Theano; Santarem, Nuno; Barrias, Emile; Pöhner, Ina; Luelmo, Sara; Afroudakis, Pantelis; Georgikopoulou, Kalliopi; Tejera Nevado, Paloma; Eick, Julia; Bifeld, Eugenia; Corral, María J; Dolores Jiménez-Antón, María; Ellinger, Bernhard; Kuzikov, Maria; Fragiadaki, Irini; Scoulica, Effie; Gul, Sheraz; Clos, Joachim; Prousis, Kyriakos C.; Torrado, Juan J; María Alunda, José; Wade, Rebecca C; de Souza, Wanderley; Cordeiro da Silva, Anabela; Calogeropo. 2023. Bioorganic chemistry. 138: A1 Journal article (refereed), original research -
Machine Learning-Boosted Docking Enables the Efficient Structure-Based Virtual Screening of Giga-Scale Enumerated Chemical Libraries
Sivula, Toni; Yetukuri, Laxman; Kalliokoski, Tuomo; Käsnänen, Heikki; Poso, Antti; Pöhner, Ina. 2023. Journal of chemical information and modeling. 63: 5773-5783 A1 Journal article (refereed), original research -
Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design
Panecka-Hofman, Joanna; Poehner, Ina. 2023. European biophysics journal with biophysics letters. 52: 521-532 A2 Review article, Literature review, Systematic review -
Anti-trypanosomatid structure-based drug design – lessons learned from targeting the folate pathway
Panecka-Hofman, Joanna; Poehner, Ina; Wade, Rebecca. 2022. Expert opinion on drug discovery. 17: 1029-1045 A2 Review article, Literature review, Systematic review -
SARS-CoV-2--host proteome interactions for antiviral drug discovery
Liu, Xiaonan; Huuskonen, Sini; Laitinen, Tuomo; Redchuk, Taras; Bogacheva, Mariia; Salokas, Kari; Pöhner, Ina; Öhman, Tiina; Tonduru, Arun Kumar; Hassinen, Antti; Gawriyski, Lisa; Keskitalo, Salla; Vartiainen, Maria K.; Pietiäinen, Vilja; Poso, Antti; Varjosalo, Markku. 2021. Molecular systems biology. 17: e10396 A1 Journal article (refereed), original research -
Virus structure and structure-based antivirals
Plavec, Zlatka; Pöhner, Ina; Poso, Antti; Butcher, Sarah J. 2021. Current opinion in virology. 51: 16-24 A2 Review article, Literature review, Systematic review