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Jaana Hartikainen

Jaana Hartikainen

Research Manager

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

[email protected] | +358 40 355 2754

Information Publications

Research groups

Non-coding RNAs in Breast Cancer
Genome Center of Eastern Finland 02.03.2009 -
Molecular Pathology and Genetics of Cancer 01.01.2022 -
Predicting the outcome and toxicity in radiothera… 01.01.2022 -

Publications

89/89 items

Circulating Micro-RNAs Predict the Risk of Recurrence in Triple-Negative Breast Cancer
Kujala, Jouni; Tengström, Maria; Heikkinen, Sami; Taipale, Mari; Kosma, Veli-Matti; Hartikainen, Jaana M; Mannermaa, Arto. 2024. Cells. 13: A1 Journal article (refereed), original research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Joutsen, Jenny; Pessa, Jenny C; Jokelainen, Otto; Sironen, Reijo; Hartikainen, Jaana M; Sistonen, Lea. 2024. Cell stress and chaperones. 29: 235-271 A1 Journal article (refereed), original research
DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Kaarijärvi, Roosa; Kaljunen, Heidi; Nappi, Lucia; Fazli, Ladan; Kung, Sonia H. Y.; Hartikainen, Jaana M.; Paakinaho, Ville; Capra, Janne; Rilla, Kirsi; Malinen, Marjo; Mäkinen, Petri I.; Ylä-Herttuala, Seppo; Zoubeidi, Amina; Wang, Yuzhuo; Gleave, Martin E.; Hiltunen, Mikko; Ketola, Kirsi. 2024. Communications biology. 7: . 108 A1 Journal article (refereed), original research
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
Mueller, Stefanie H.; Lai, Alvina G.; Valkovskaya, Maria; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Abu-Ful, Zomoruda; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baert, Thais; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Bonanni, Bernardo; Brenner. 2023. Genome medicine. 15: . 7 A1 Journal article (refereed), original research
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival
Morra, Anna; Schreurs, Maartje A. C.; Andrulis, Irene L.; Anton-Culver, Hoda; Augustinsson, Annelie; Beckmann, Matthias W.; Behrens, Sabine; Bojesen, Stig E.; Bolla, Manjeet K.; Brauch, Hiltrud; Broeks, Annegien; Buys, Saundra S.; Camp, Nicola J.; Castelao, Jose E.; Cessna, Melissa H.; Chang-Claude, Jenny; Chung, Wendy K.; Colonna, Sarah, V; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Dennis, Joe; Devilee, Peter; Doerk, Thilo; Dunning, Alison M.; Dwek, Miriam; E. 2023. Cancer medicine. 12: 16142-16162 A1 Journal article (refereed), original research
Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease
Azimzadeh, Omid; Moertl, Simone; Ramadan, Raghda; Baselet, Bjorn; Laiakis, Evagelia C.; Sebastian, Soji; Beaton, Danielle; Hartikainen, Jaana M.; Kaiser, Jan Christian; Beheshti, Afshin; Salomaa, Sisko; Chauhan, Vinita; Hamada, Nobuyuki. 2022. International journal of radiation biology. 98: 1722-1751 A2 Review article, Literature review, Systematic review
Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors
Kujala, Jouni; Hartikainen, Jaana M.; Tengström, Maria; Sironen, Reijo; Auvinen, Päivi; Kosma, Veli Matti; Mannermaa, Arto. 2022. Cancers. 14: . 1332 A1 Journal article (refereed), original research
Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M.. 2022. Scientific reports. 12: . 22614 A1 Journal article (refereed), original research
M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling
Kainulainen, Kirsi; Takabe, Piia; Heikkinen, Sami; Aaltonen, Niina; de la Motte, Carol; Rauhala, Leena; Durst, Franziska C; Oikari, Sanna; Hukkanen, Taija; Rahunen, Eija; Ikonen, Ella; Hartikainen, Jaana M; Ketola, Kirsi; Pasonen-Seppänen, Sanna. 2022. Journal of investigative dermatology. 1412: 3041-3051.e10 A1 Journal article (refereed), original research
MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration
Aaltonen, Niina; Kyykallio, Heikki; Tollis, Sylvain; Capra, Janne; Hartikainen, Jaana M.; Matilainen, Johanna; Oikari, Sanna; Rilla, Kirsi. 2022. Frontiers in oncology. 12: . 869417 A1 Journal article (refereed), original research
Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes
Breast Cancer Association Consortium; Mavaddat, Nasim; Dorling, Leila; Carvalho, Sara; Allen, Jamie; González-Neira, Anna; Keeman, Renske; Bolla, Manjeet K.; Dennis, Joe; Wang, Qin; Ahearn, Thomas U.; Andrulis, Irene L.; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Briceno, Ignacio; Brüning, Thomas; Camp, Nicola J.; Campbell, Archie; Castelao, Jose E.; Chang-Claude, Jenny; Chanock, Stephen J.; Chenevix-Tren. 2022. JAMA oncology. 8: A1 Journal article (refereed), original research
Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Morra, Anna; Escala-Garcia, Maria; Beesley, Jonathan; Keeman, Renske; Canisius, Sander; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Auer, Paul L; Augustinsson, Annelie; Beane Freeman, Laura E; Becher, Heiko; Beckmann, Matthias W; Behrens, Sabine; Bojesen, Stig E; Bolla, Manjeet K; Brenner, Hermann; Brüning, Thomas; Buys, Saundra S; et al; [incl. Hartikainen, Jaana; Mannermaa, Arto]. 2021. Breast cancer research. 23: 86 A1 Journal article (refereed), original research
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
Dorling, Leila; Carvalho, Sara; Allen, Jamie; González-Neira, Anna; Luccarini, Craig; Wahlström, Cecilia; Pooley, Karen A.; Parsons, Michael T.; Fortuno, Cristina; Wang, Qin; Bolla, Manjeet K.; Dennis, Joe; Keeman, Renske M.; Alonso, Rosario; Álvarez, Nuria; Herraez, Belen; Fernandez, Victoria; Núñez-Torres, Rocio; Osorio, Ana; Valcich, Jeanette et al. [incl. Hartikainen, Jaana; Kosma, Veli-Matti; Mannermaa, Arto]. 2021. The new england journal of medicine. 384: 428-439 A1 Journal article (refereed), original research
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Oncogene. 40: 4567-4579 A1 Journal article (refereed), original research
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
Park, JooYong; Choi, Ji-Yeob; Choi, Jaesung; Chung, Seokang; Song, Nan; Park, Sue K; Han, Wonshik; Noh, Dong-Young; Ahn, Sei-Hyun; Lee, Jong Won; Kim, Mi Kyung; Jee, Sun Ha; Wen, Wanqing; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Shah, Mitul; Conroy, Don M; Harrington, Patricia A; et al; [incl. Mannermaa, Arto; Hartikainen, Jaana]. 2021. Cancers. 13: 2370 A1 Journal article (refereed), original research
Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis
Escala-Garcia, Maria; Canisius, Sander; Keeman, Renske; Beesley, Jonathan; Anton-Culver, Hoda; Arndt, Volker; Augustinsson, Annelie; Becher, Heiko; Beckmann, Matthias W.; Behrens, Sabine; Bermisheva, Marina; Bojesen, Stig E.; Bolla, Manjeet K.; Brenner, Hermann; Canzian, Federico; Castelao, Jose E.; Chang-Claude, Jenny; Chanock, Stephen J.; Couch, Fergus J.; Czene, Kamila et al. [incl. Hartikainen, Jaana M; Mannermaa, Arto]. 2021. Scientific reports. 11: 19787 A1 Journal article (refereed), original research
The debatable presence of PIWI-interacting RNAs in invasive breast cancer
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M. 2021. Cancer medicine. 10: 3593 - 3603 A1 Journal article (refereed), original research
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Fachal, L; Aschard, H; Beesley, J; Barnes, DR; Allen, J; Kar, S; Pooley, KA; Dennis, J; Michailidou, K; Turman, C; Soucy, P; Lemaçon, A; Lush, M; Tyrer, JP; Ghoussaini, M; Marjaneh, MM; Jiang, X; Agata, S; Aittomäki, K; Alonso, MR; et al. [incl. Hartikainen, J; Kosma, VM; Mannermaa, A; Tengström, M]. 2020. Nature genetics. 52: 56-73 A1 Journal article (refereed), original research
High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival
Kujala, J; Hartikainen, JM; Tengström, M; Sironen, R; Kosma, VM; Mannermaa, A. 2020. Cancer medicine. 9: 5922-5931 A1 Journal article (refereed), original research
MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer
Eneh, Stralina; Heikkinen, Sami; Hartikainen, Jaana M; Kuopio, Teijo; Mecklin, Jukka-Pekka; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Anticancer research. 40: 3713-3722 A1 Journal article (refereed), original research
Predicting Breast Cancer Risk Using Interacting Genetic and Demographic Factors and Machine Learning
Behravan, Hamid; Hartikainen, Jaana M; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Scientific reports. 10: 11044 A1 Journal article (refereed), original research
CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells
Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K. 2019. Cells. 8: 276 A1 Journal article (refereed), original research
Clinical and epidemiological observations on individual radiation sensitivity and susceptibility
Seibold, P; Auvinen, A; Averbeck, D; Bourguignon, M; Hartikainen, JM; Hoeschen, C; Laurent, O; Noël, G; Sabatier, L; Salomaa, S; Blettner, M. 2019. International journal of radiation biology. 2020; 96: 324-339 A2 Review article, Literature review, Systematic review
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma
Sallinen, H; Janhonen, S; Pölönen, P; Niskanen, H; Liu, OH; Kivelä, A; Hartikainen, JM; Anttila, M; Heinäniemi, M; Ylä-Herttuala, S; Kaikkonen, MU. 2019. Bmc cancer. 19: 1121 A1 Journal article (refereed), original research
Genome-wide association study of germline variants and breast cancer-specific mortality
Escala-Garcia, M; Guo, Q; Dörk, T; Canisius, S; Keeman, R; Dennis, J; Beesley, J; Lecarpentier, J; Bolla, MK; Wang, Q; Abraham, J; Andrulis, IL; Anton-Culver, H; Arndt, V; Auer, PL; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; et al. (Incl. Hartikainen, Jaana; Kosma, Veli-Matti; Mannermaa, Arto; Tengström, Maria). 2019. British journal of cancer. 120: 647-657 A1 Journal article (refereed), original research
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Pölönen, P; Jawahar Deen, A; Leinonen, HM; Jyrkkänen, HK; Kuosmanen, S; Mononen, M; Jain, A; Tuomainen, T; Pasonen-Seppänen, S; Hartikainen, JM; Mannermaa, A; Nykter, M; Tavi, P; Johansen, T; Heinäniemi, M; Levonen, AL. 2019. Oncogene. 38: 7473-7490 A1 Journal article (refereed), original research
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
Horne, HN; Oh, H; Sherman, ME; Palakal, M; Hewitt, SM; Schmidt, MK; Milne, RL; Hardisson, D; Benitez, J; Blomqvist, C; Bolla, MK; Brenner, H; Chang-Claude, J; Cora, R; Couch, FJ; Cuk, K; Devilee, P; Easton, DF; Eccles, DM; Eilber, U; et al [Incl Mannermaa, A; Tengström, M]. 2018. Scientific reports. 8: 6574 A1 Journal article (refereed), original research
Machine learning identifies interacting genetic variants contributing to breast cancer risk: a case study in Finnish cases and controls
Behravan, Hamid; Hartikainen, Jaana M; Tengström, Maria; Pylkäs, Katri; Winqvist, Robert; Kosma, Veli-Matti; Mannermaa, Arto. 2018. Scientific reports. 8: 13149 A1 Journal article (refereed), original research
Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer
Tervasmäki, Anna; Mantere, Tuomo; Hartikainen, Jaana M; Kauppila, Salla; Lee, Hang-Mao; Koivuluoma, Susanna; Grip, Mervi; Karihtala, Peeter; Jukkola-Vuorinen, Arja; Mannermaa, Arto; Winqvist, Robert; Pylkäs, Katri. 2018. International journal of cancer. 142: 2286-2292 A1 Journal article (refereed), original research
Association analysis identifies 65 new breast cancer risk loci
Michailidou K, Lindstrom S, Dennis J, Beesley J, Hui S, Kar S, Lemacon A, Soucy P, Glubb D, Rostamianfar A, Bolla MK, Wang Q, Tyrer J, Dicks E, Lee A, Wang ZM, Allen J, Keeman R, Eilber U, French JD et al.. 2017. Nature. 551: 92-94 A1 Journal article (refereed), original research
Body mass index and breast cancer survival: a Mendelian randomization analysis
Guo Q, Burgess S, Turman C, Bolla MK, Wang Q, Lush M, Abraham J, Aittomäki K, Andrulis IL, Apicella C, Arndt V, Barrdahl M, Benitez J, Berg CD, Blomqvist C, Bojesen SE, Bonanni B, Brand JS, Brenner H, Broeks A et al. [Incl. Hartikainen J, Kataja V, Kosma V-M, Mannermaa A]. 2017. International journal of epidemiology. 46: 1814-1822 A1 Journal article (refereed), original research
Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility
Mantere T, Tervasmäki A, Nurmi A, Rapakko K, Kauppila S, Tang J, Schleutker J, Kallioniemi A, Hartikainen JM, Mannermaa A, Nieminen P, Hanhisalo R, Lehto S, Suvanto M, Grip M, Jukkola-Vuorinen A, Tengström M, Auvinen P, Kvist A, Borg Å et al. 2017. Scientific reports. 7: 681 A1 Journal article (refereed), original research
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J et al [incl. Hartikainen Juha, Mannermaa Arto, Tengström Maria]. 2017. Nature genetics. 49: 1767-1778 A1 Journal article (refereed), original research
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
Zeng Chenjie, Guo Xingyi, Long Jirong, Kuchenbaecker Karoline B, Droit Arnaud, Michailidou Kyriaki, Ghoussaini Maya, Kar Siddhartha, Freeman Adam, Hopper John L, Milne Roger L, Bolla Manjeet K, Wang Qin, Dennis Joe, Agata Simona, Ahmed Shahana, Aittomäki Kristiina, Andrulis Irene L, Anton-Culver Hoda, Antonenkova Natalia N et al. 2016. Breast cancer research. 18: 64 A1 Journal article (refereed), original research
KEAP1-geenin variantit rintasyövässä
Hartikainen, Jaana. 2016. BestPractice: Onkologia/Hematologia. 14: 12-13 D1 Article in a trade journal
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Consortium of Modifiers of BRCA1 and BRCA2, Hollestelle Antoinette, van der Baan Frederieke H, Berchuck Andrew, Johnatty Sharon E, Aben Katja K, Agnarsson Bjarni A, Aittomäki Kristiina, Alducci Elisa, Andrulis Irene L, Anton-Culver Hoda, Antonenkova Natalia N, Antoniou Antonis C, Apicella Carmel, Arndt Volker, Arnold Norbert, Arun Banu K, Arver Brita, Ashworth Alan, Baglietto Laura, Balleine Rosemary et al. (incl. Jaana. 2016. Gynecologic oncology. 141: 386-401 A2 Review article, Literature review, Systematic review
PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS
Southey MC, Goldgar DE, Winqvist R, Pylkäs K, Couch F, Tischkowitz M, Foulkes WD, Dennis J, Michailidou K, van Rensburg EJ, Heikkinen T, Nevanlinna H, Hopper JL, Dörk T, Claes KB, Reis-Filho J, Teo ZL, Radice P, Catucci I, Peterlongo P et al. 2016. Journal of medical genetics. 53: 800-811 A1 Journal article (refereed), original research
RAD51B in Familial Breast Cancer
Pelttari Liisa M, Khan Sofia, Vuorela Mikko, Kiiski Johanna I, Vilske Sara, Nevanlinna Viivi, Ranta Salla, Schleutker Johanna, Winqvist Robert, Kallioniemi Anne, Dörk Thilo, Bogdanova Natalia V, Figueroa Jonine, Pharoah Paul DP, Schmidt Marjanka K, Dunning Alison M, García-Closas Montserrat, Bolla Manjeet K, Dennis Joe, Michailidou Kyriaki et al. 2016. PLoS ONE. 11: e0153788 A1 Journal article (refereed), original research
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients
Seibold Petra, Schmezer Peter, Behrens Sabine, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Flesch-Janys Dieter, Nevanlinna Heli, Fagerholm Rainer, Aittomäki Kristiina, Blomqvist Carl, Margolin Sara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Lambrechts Diether, Wildiers Hans, Kristensen Vessela, Alnæs Grethe Grenaker et al. 2015. Bmc cancer. 15: 978 A1 Journal article (refereed), original research
Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis
Sobral-Leite Marcelo, Wesseling Jelle, Smit Vincent THBM, Nevanlinna Heli, van Miltenburg Martine H, Sanders Joyce, Hofland Ingrid, Blows Fiona M, Coulson Penny, Patrycja Gazinska, Schellens Jan HM, Fagerholm Rainer, Heikkilä Päivi, Aittomäki Kristiina, Blomqvist Carl, Provenzano Elena, Ali Hamid Raza, Figueroa Jonine, Sherman Mark, Lissowska Jolanta et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Bmc medicine. 13: 156 A1 Journal article (refereed), original research
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy
Lei Jieping, Rudolph Anja, Moysich Kirsten B, Rafiq Sajjad, Behrens Sabine, Goode Ellen L, Pharoah Paul PD, Seibold Petra, Fasching Peter A, Andrulis Irene L, Kristensen Vessela N, Couch Fergus J, Hamann Ute, Hooning Maartje J, Nevanlinna Heli, Eilber Ursula, Bolla Manjeet K, Dennis Joe, Wang Qin, Lindblom Annika et al (incl. Mannermaa Arto, Kosma Veli-Matti, Hartikainen Jaana M, Kataja Vesa). 2015. Breast cancer research. 17: - A1 Journal article (refereed), original research
Common germline polymorphisms associated with breast cancer specific survival
Pirie Ailith, Guo Qi, Kraft Peter, Canisius Sander, Eccles Diana M, Rahman Nazneen, Nevanlinna Heli, Chen Constance, Khan Sofia, Tyrer Jonathan, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Lush Michael, Dunning Alison M, Shah Mitul, Czene Kamila, Darabi Hatef, Eriksson Mikael et al (incl. Vesa Kataja, Jaana Hartikainen, Veli-Matti Kosma). 2015. Breast cancer research. 17: - A1 Journal article (refereed), original research
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Orr Nick, Dudbridge Frank, Dryden Nicola, Maguire Sarah, Novo Daniela, Perrakis Eleni, Johnson Nichola, Ghoussaini Maya, Hopper John L, Southey Melissa C, Apicella Carmel, Stone Jennifer, Schmidt Marjanka K, Broeks Annegien, Van't Veer Laura J, Hogervorst Frans B, Fasching Peter A, Haeberle Lothar, Ekici Arif B, Beckmann Matthias W et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Human molecular genetics. 24: 2966-2984 A1 Journal article (refereed), original research
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1
Glubb Dylan M, Maranian Mel J, Michailidou Kyriaki, Pooley Karen A, Meyer Kerstin B, Kar Siddhartha, Carlebur Saskia, O'Reilly Martin, Betts Joshua A, Hillman Kristine M, Kaufmann Susanne, Beesley Jonathan, Canisius Sander, Hopper John L, Southey Melissa C, Tsimiklis Helen, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Hogervorst Frans B et al (incl. Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti KosmaI). 2015. American journal of human genetics. 96: 5-20 A1 Journal article (refereed), original research
Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium
Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, Bolla MK, Dennis J, Dunning AM, Easton DF, Wang Q, Benitez J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Fasching PA, Haeberle L, Peto J, Dos-Santos-Silva I, Sawyer EJ et al.. 2015. Human genetics. 135: 137-154 A1 Journal article (refereed), original research
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Michailidou Kyriaki, Beesley Jonathan, Lindstrom Sara, Canisius Sander, Dennis Joe, Lush Michael J, Maranian Mel J, Bolla Manjeet K, Wang Qin, Shah Mitul, Perkins Barbara J, Czene Kamila, Eriksson Mikael, Darabi Hatef, Brand Judith S, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Nielsen Sune F, Rahman Nazneen et al (incl. Arto Mannermaa, Jaana Hartikainen, Veli-Matti Kosma, Vesa Kataja). 2015. Nature genetics. 47: 373-380 A1 Journal article (refereed), original research
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization
Zhang Ben, Shu Xiao-Ou, Delahanty Ryan J, Zeng Chenjie, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Wen Wanqing, Long Jirong, Li Chun, Dunning Alison M, Chang-Claude Jenny, Shah Mitul, Perkins Barbara J, Czene Kamila, Darabi Hatef, Eriksson Mikael, Bojesen Stig E, Nordestgaard Børge G et al. (incl. Mannermaa A, Kataja V, Kosma V-M, Hartikainen JM). 2015. Journal of the national cancer institute. 107: djv219 A1 Journal article (refereed), original research
Identification of Novel Genetic Markers of Breast Cancer Survival
Guo Qi, Schmidt Marjanka K, Kraft Peter, Canisius Sander, Chen Constance, Khan Sofia, Tyrer Jonathan, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Lush Michael, Kar Siddhartha, Beesley Jonathan, Dunning Alison M, Shah Mitul, Czene Kamila, Darabi Hatef, Eriksson Mikael, Lambrechts Diether et al. (incl. Mannermaa Arto). 2015. Journal of the national cancer institute. 107: djv081 A1 Journal article (refereed), original research
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer
Kabisch Maria, Bermejo Justo Lorenzo, Dünnebier Thomas, Ying Shibo, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Shah Mitul, Perkins Barbara J, Czene Kamila, Darabi Hatef, Eriksson Mikael, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Lambrechts Diether, Neven Patrick, Peeters Stephanie et al (incl.. 2015. Carcinogenesis. 36: 256-271 A1 Journal article (refereed), original research
KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes
Hartikainen Jaana M, Tengström Maria, Winqvist Robert, Jukkola-Vuorinen Arja, Pylkäs Katri, Kosma Veli-Matti, Soini Ylermi, Mannermaa Arto. 2015. Clinical cancer research. 21: - A1 Journal article (refereed), original research
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Mavaddat Nasim, Pharoah Paul DP, Michailidou Kyriaki, Tyrer Jonathan, Brook Mark N, Bolla Manjeet K, Wang Qin, Dennis Joe, Dunning Alison M, Shah Mitul, Luben Robert, Brown Judith, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Czene Kamila, Darabi Hatef, Eriksson Mikael, Peto Julian et al (incl. Arto Mannermaa). 2015. Journal of the national cancer institute. 107: djv036 A1 Journal article (refereed), original research
2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Li Jingmei, Lindström Linda S, Foo Jia N, Rafiq Sajjad, Schmidt Marjanka K, Pharoah Paul DP, Michailidou Kyriaki, Dennis Joe, Bolla Manjeet K, Wang Qin, Van 't Veer Laura J, Cornelissen Sten, Rutgers Emiel, Southey Melissa C, Apicella Carmen, Dite Gillian S, Hopper John S, Fasching Peter A, Haeberle Lothar, Ekici Arif B et al. 2014. Nature communications. : 4051 A1 Journal article (refereed), original research
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium
Milne RL, Herranz J, Michailidou K, Dennis J, Tyrer JP, Zamora MP, Arias-Perez JI, González-Neira A, Pita G, Alonso MR, Wang Q, Bolla MK, Czene K, Eriksson M, Humphreys K, Darabi H,..., Mannermaa A, Kataja V, Kosma VM, Hartikainen J, et al.. 2014. Human molecular genetics. 23: 1934-1946 A1 Journal article (refereed), original research
Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium
Milne RL, Burwinkel B, Michailidou K, Arias-Perez JI, Zamora MP, Menéndez-Rodríguez P, Hardisson D, Mendiola M, González-Neira A, Pita G, Alonso MR, Dennis J, Wang Q, Bolla MK, Swerdlow A, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. Human molecular genetics. 23: 6096-6111 A1 Journal article (refereed), original research
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. Nature communications. 4: Article number:4999 A1 Journal article (refereed), original research
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT, Mannermaa A, Kataja V, Kosma V-M, Hartikainen J, Easton DF, Pharoah PDP, Arias-Perez JI, Zamora P, Benitez J, Milne RL et.al. 2014. British journal of cancer. 110: 1088-1100 A1 Journal article (refereed), original research
Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer
Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen JM, Kosma VM, Laasanen SL, Mannermaa A, Pylkäs K, Winqvist R. 2014. Clinical genetics. 88: 68-73 A2 Review article, Literature review, Systematic review
Genetic predisposition to in situ and invasive lobular carcinoma of the breast
Sawyer Elinor, Roylance Rebecca, Petridis Christos, Brook Mark N, Nowinski Salpie, Papouli Efterpi, Fletcher Olivia, Pinder Sarah, Hanby Andrew, Kohut Kelly, Gorman Patricia, Caneppele Michele, Peto Julian, dos Santos Silva Isabel, Johnson Nichola, Swann Ruth, Dwek Miriam, Perkins Katherine-Anne, Gillett Cheryl, Houlston Richard et al (incl. Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M,). 2014. PLoS genetics. 10: e1004285 A1 Journal article (refereed), original research
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Johnson Nichola, Dudbridge Frank, Orr Nick, Gibson Lorna, Jones Michael E, Schoemaker Minouk J, Folkerd Elizabeth J, Haynes Ben P, Hopper John L, Southey Melissa C, Dite Gillian S, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Van T Veer Laura J, Atsma Femke et al. 2014. Breast cancer research and treatment. 16: R51 A1 Journal article (refereed), original research
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Purrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P, Carpenter J, Yannoukakos D, Haiman CA, Fasching PA, Mannermaa A, ...,Hartikainen JM, Kosma VM, Kataja V, et al.. 2014. Human molecular genetics. 23: 6034-6046 A1 Journal article (refereed), original research
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL, Apicella C, Southey MC, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Th Rutgers EJ, Muir K, Lophatananon A, Stewart-Brown S, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, kConFab Investigators; Australian Ovarian Cancer Study Group, et al.. 2014. Human molecular genetics. 2014: 1-14 A1 Journal article (refereed), original research
Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions
Schoeps Anja, Rudolph Anja, Seibold Petra, Dunning Alison M, Milne Roger L, Bojesen Stig E, Swerdlow Anthony, Andrulis Irene, Brenner Hermann, Behrens Sabine, Orr Nicholas, Jones Michael, Ashworth Alan, Li Jingmei, Cramp Helen, Connley Dan, Czene Kamila, Darabi Hatef, Chanock Stephen J, Lissowska Jolanta et al (incl Kosma Veli-Matti, Kataja Vesa, Hartikainen Jaana M, Mannermaa Arto). 2014. Genetic epidemiology. 38: 84-93 A1 Journal article (refereed), original research
Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
Rudolph A, Milne RL, Truong T, Knight JA, Seibold P, Flesch-Janys D, Behrens S, Eilber U, Bolla MK, Wang Q, Dennis J, Dunning AM, Shah M, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. International journal of cancer. 136: E685-E696 A1 Journal article (refereed), original research
MicroRNA Related Polymorphisms and Breast Cancer Risk
Khan Sofia, Greco Dari, Michailidou Kyriaki, Milne Roger L, Muranen Taru A, Heikkinen Tuomas, Aaltonen Kirsimari, Dennis Joe, Bolla Manjeet K, Liu Jianjun, Hall Per, Irwanto Astrid, Humphreys Keith, Li Jingmei, Czene Kamila, Chang-Claude Jenny, Hein Rebecca, Rudolp Anja, Seibold Petra, Flesch-Janys Dieter et at (including Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Mannermaa Arto). 2014. PLoS ONE. 9: e109973 (1-12) A1 Journal article (refereed), original research
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
Spurdle Amanda B, Couch Fergus J, Parsons Michael T, McGuffog Lesley, Barrowdale Daniel, Bolla Manjeet K, Wang Qin, Healey Sue, Schmutzler Rita Katharina, Wappenschmidt Barbara, Rhiem Kerstin, Hahnen Eric, Engel Christoph, Meindl Alfons, Ditsch Nina, Norbert Arnold, Plendl Hansjoerg, Niede et al. (incl. Hartikainen Jaana)racher Dieter, Sutter Christian, Wang-Gohrke Shan,. 2014. Breast cancer research. 16: 3419 A1 Journal article (refereed), original research
Type II Transmembrane Serine Protease Gene Variants Associate with Breast Cancer
Luostari Kaisa, Hartikainen Jaana M, Tengström Maria, Palvimo Jorma J, Kataja Vesa, Mannermaa Arto, Kosma Veli-Matti. 2014. PLoS ONE. 9: e102519 A1 Journal article (refereed), original research
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
Nickels S, Truong T, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt M, Häberle L, Vrieling A, Gaudet M, Figueroa J, Schoof N, Spurdle AB, Rudolph A, Fasching PA, Hopper JL, Makalic E, Schmidt DF, Southey MC, Beckmann MW, Ekici AB, Fletcher O, Gibson L, Silva Idos S, Peto J, Humphreys MK, Wang J, Cordina-Duverger E, Menegaux F, Nordestgaard BG, Bojesen SE, Lanng C, Anton-Culver H, Ziogas A, Bernstein L, Clarke CA, Brenner H, Müller H, Arndt V, Stegmaier C, Brauch H, Brüning T, Harth V; G. 2013. PLoS genetics. 9: e1003284 A1 Journal article (refereed), original research
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1
Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD, Prathalingham R, Dennis J, Bolla MK, Wang Q, de Santiago I, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Schmidt MK, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2013. American journal of human genetics. 93: 1046-1060 A1 Journal article (refereed), original research
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S, Khan S, Maranian MJ, O'Reilly M, Hillman KM, Betts JA, Carroll T, Bailey PJ, Dicks E et.al.. 2013. American journal of human genetics. 92: 489-503 A1 Journal article (refereed), original research
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le Marchand L, Buring JE, Eccles D, et. al. 2013. Nature genetics. 45: 392-8 A1 Journal article (refereed), original research
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A et. al. 2013. Nature genetics. 45: 353-61 A1 Journal article (refereed), original research
Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer
Tuhkanen H, Hartikainen JM, Soini Y, Velasco G, Sironen R, Nykopp TK, Kataja V, Eskelinen M, Kosma VM, Mannermaa A.. 2013. International journal of cancer. 133: 2334-2340 A1 Journal article (refereed), original research
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz et al. 2013. Nature genetics. 45: 371-84 A1 Journal article (refereed), original research
The UGT1A6_19_GG genotype is a breast cancer risk factor
Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V, Pesch B, Brüning T, Baisch C, Hartikainen JM, Mannermaa A, Kosma VM, Kataja V, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Fasching PA, Beckmann M, Ekici AB, Hein A, Hall P, Li J, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Hamann U, Ko YD, Brauch H. & al.. 2013. Frontiers in genetics. 4: 1-6 A1 Journal article (refereed), original research
11q13 is a susceptibility locus for hormone receptor positive breast cancer
Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI et.al.. 2012. Human mutation. 33: 1123-1132 A1 Journal article (refereed), original research
19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus
Stevens Kristen N, Fredericksen Zachary, Vachon Celine M, Wang Xianshu, Margolin Sara, Lindblom Annika, Nevanlinna Heli, Greco Dario, Aittomäki Kristiina, Blomqvist Carl, Chang-Claude Jenny, Vrieling Alina, Flesch-Janys Dieter, Sinn Hans-Peter, Wang-Gohrke Shan, Nickels Stefan, Brauch Hiltrud, Ko Yon-Dschun, Fischer Hans-Peter, Schmutzler Rita K. 2012. Cancer research. 72: 1795-1803 A1 Journal article (refereed), original research
9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
Warren H, Dudbridge F, Fletcher O, Orr N, Johnson N, Hopper JL, Apicella C, Southey MC, Mahmoodi M, Schmidt MK, Broeks A, Cornelissen S, Braaf LM, Muir KR, Lophatananon A, Chaiwerawattana A, Wiangnon S, Fasching PA, Beckmann MW, Ekici AB et al. 2012. Cancer epidemiology biomarkers and prevention. 21: 1783-1791 A1 Journal article (refereed), original research
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions
Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R.. 2012. Science translational medicine. 4: 122-123 A1 Journal article (refereed), original research
Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association consortium (BCAC)
Hein R, Maranian M, Hopper J L, Kapuscinski M K, Southey M C, Park D J, Schmidt M K, Broeks A, Hogervorst F B L, Bueno-de-Mesquit H B, Muir K R, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching P A, Hein A, Ekici A B, Beckmann M W, Fletcher O, Johnson N, et.al.. 2012. PLoS ONE. 7: - A1 Journal article (refereed), original research
Genetic Polymorphisms and Protein Expression of NRF2 and Sulfiredoxin Predict Survival Outcomes in Breast Cancer
Hartikainen JM,Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y.. 2012. Cancer research. 72: 5537-5546 A1 Journal article (refereed), original research
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Drive K, Johnson N, Orr N, Dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, et al. 2012. Nature genetics. 44: 312-318 A1 Journal article (refereed), original research
The role of genetic breast cancer susceptibility variants as prognostic factors
Fasching PA, Pharoah PD, Cox A, Nevanlinna H, Bojesen SE, Karn T, Broeks A, Van Leeuwen FE, Van't Veer LJ, Udo R, Dunning AM, Greco D, Aittomäki K, Blomqvist C, Shah M, Nordestgaard BG, Flyger H, Hopper JL, Southey MC, Apicella C, et.al.. 2012. Human molecular genetics. 21: 3926-3939 A1 Journal article (refereed), original research
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Yang Xiaohong R, Chang-Claude Jenny, Goode Ellen L, Couch Fergus J, Nevanlinna Heli, Milne Roger L, Gaudet Mia, Schmidt Marjanka K, Broeks Annegien, Cox Angela, Fasching Peter A, Hein Rebecca, Spurdle Amanda B, Blows Fiona, Driver Kristy, Flesch-Janys Dieter, Heinz Judith, Sinn Peter, Vrieling Alina, Heikkinen Tuomas et al. 2011. Journal of the national cancer institute. 103: 250-263 A1 Journal article (refereed), original research
Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer.
Milne RL, Goode EL, García-Closas M, Couch FJ, Severi G, Hein R, Fredericksen Z, Malats N, Zamora MP, Pérez JI, Benítez J, Dörk T, Schürmann P, Karstens JH, Hillemanns P, Cox A, Brock IW, Elliot G, Cross SS, Seal S, Turnbull C, Renwick A, Rahman N, Shen CY, Yu JC, Huang CS, Hou MF, Nordestgaard BG, Bojesen SE, Lanng C, Alnæs GG, Kristensen V, Børrensen-Dale AL, Hopper JL, Dite GS, Apicella C, Southey MC, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Sangrajrang S, Gaborieau V, Brennan P, McKay. 2011. Cancer epidemiology biomarkers and prevention. 20: 2222-2231 A1 Journal article (refereed), original research
Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.
Stevens KN, Garcia-Closas M, Fredericksen Z, Kosel M, Pankratz VS, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Tollenaar RA, Fasching PA, Beckmann MW, Hein A, Ekici AB, Johnson N, Peto J, Dos Santos Silva I, Gibson L, Sawyer E, Tomlinson I, Kerin MJ, Chanock S, Lissowska J, Hunter DJ, Hoover RN, Thomas GD, Milne RL, Pérez JA, González-Neira A, Benítez J, Burwinkel B, Meindl A, Schmutzler RK, Bartrar CR, Hamann U, Ko YD, Brüning T, Chang-Claude J, Hein R, Wan. 2011. British journal of cancer. 105: 1934-9 A1 Journal article (refereed), original research
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Vuorela M, Pylkäs K, Hartikainen JM, Sundfeldt K, Lindblom A, von Wachenfeldt Wäppling A, Haanpää M, Puistola U, Rosengren A, Anttila M, Kosma VM, Mannermaa A, Winqvist R.. 2011. Breast cancer research and treatment. 130: 1003-10 A1 Journal article (refereed), original research
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Broeks, Annegien; Schmidt, Marjanka K; Sherman, Mark E; Couch, Fergus J; Hopper, John L; Dite, Gillian S; Apicella, Carmen; Smith, Letitia D; Hammet, Fleur; Southey, Melissa C; Van't Veer, Laura J; de Groot, Renate; Smit, Vincent T. H. B. M; Fasching, Peter A; Beckmann, Matthias W; Jud, Sebastian; Ekici, Arif B; Hartmann, Arndt; Hein, Alexander; Schulz-Wendtland, Ruediger et al.. 2011. Human molecular genetics. 20: 3289-3303 A1 Journal article (refereed), original research
ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival
Kauppinen J, Kosma V-M, Soini Y, Sironen R, Nissinen M, Nykopp T, Kärjä V, Eskelinen M, Kataja V, Mannermaa A. 2010. Cancer epidemiology biomarkers and prevention. 19: 2133-2142 A1 Journal article (refereed), original research
Genetic Predisposition to Breast and Ovarian Cancer in Eastern Finnish Population
Hartikainen J. 2007. Kuopio University Publications D. Medical Sciences G5 Doctoral dissertation (article)

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Jaana Hartikainen

Research groups

Circulating Micro-RNAs Predict the Risk of Recurrence in Triple-Negative Breast Cancer

Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival

Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors

Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells

Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

The debatable presence of PIWI-interacting RNAs in invasive breast cancer

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

High Mutation Burden of Circulating Cell-Free DNA in Early-Stage Breast Cancer Patients Is Associated With a Poor Relapse-Free Survival

MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer

Predicting Breast Cancer Risk Using Interacting Genetic and Demographic Factors and Machine Learning

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

Clinical and epidemiological observations on individual radiation sensitivity and susceptibility

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

Genome-wide association study of germline variants and breast cancer-specific mortality

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Machine learning identifies interacting genetic variants contributing to breast cancer risk: a case study in Finnish cases and controls

Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer

Association analysis identifies 65 new breast cancer risk loci

Body mass index and breast cancer survival: a Mendelian randomization analysis

Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus

KEAP1-geenin variantit rintasyövässä

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS

RAD51B in Familial Breast Cancer

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Common germline polymorphisms associated with breast cancer specific survival

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

Identification of Novel Genetic Markers of Breast Cancer Survival

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer

KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes

Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer

Genetic predisposition to in situ and invasive lobular carcinoma of the breast

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

MicroRNA Related Polymorphisms and Breast Cancer Risk

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Type II Transmembrane Serine Protease Gene Variants Associate with Breast Cancer

Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

The UGT1A6_19_GG genotype is a breast cancer risk factor

11q13 is a susceptibility locus for hormone receptor positive breast cancer

19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus

9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium