Jagadish Vangipurapu

Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Madsen, AL.; Bonàs-Guarch, S; Gheibi, S; Prasad, R; Vangipurapu, J; Ahuja, V.; Cataldo, LR; Dwivedi, O; Hatem, G; Atla, G; Guindo-Martínez, M; Jørgensen, AM; Jonsson, AE; Miguel-Escalada, I; Hassan, S; Linneberg, A; Ahluwalia, Tarunveer S; Drivsholm, T; Pedersen, O; Sørensen, T A.; Astrup, A; Witte, D; Damm, P; Clausen, TD; Mathiesen, E; Pers, TH; Loos, RJF; Hakaste, L; Fex, M; Grarup, N; Tuomi, T; Laakso, M; Mulder, H; Ferrer, J; Hansen, T. 2024. Nature metabolism. 6: 1897-1912 A1 Journal article (refereed), original research

Metabolomics-Based Machine Learning for Predicting Mortality: Unveiling Multisystem Impacts on Health

Oravilahti, Anniina; Vangipurapu, Jagadish; Laakso, Markku; Fernandes Silva, Lilian. 2024. International journal of molecular sciences. 25: A1 Journal article (refereed), original research

Novel Metabolites Associated with Decreased GFR in Finnish Men: A 12-Year Follow-Up of the METSIM Cohort

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2024. International journal of molecular sciences. 25: A1 Journal article (refereed), original research

Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study

Kujala, Iida; Vangipurapu, Jagadish; Maaniitty, Teemu; Saraste, Antti; Kere, Juha; Knuuti, Juhani. 2024. Journal of atherosclerosis and thrombosis. 31: 1058-1071 A1 Journal article (refereed), original research

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Brown, Andrew A.; Fernandez-Tajes, Juan J.; Hong, Mun-gwan; Brorsson, Caroline A.; Koivula, Robert W.; Davtian, David; Dupuis, Théo; Sartori, Ambra; Michalettou, Theodora-Dafni; Forgie, Ian M.; Adam, Jonathan; Allin, Kristine H.; Caiazzo, Robert; Cederberg, Henna; De Masi, Federico; Elders, Petra J. M.; Giordano, Giuseppe N.; Haid, Mark; Hansen, Torben; Hansen, Tue H.; Hattersley, Andrew T.; Heggie, Alison J.; Howald, Cédric; Jones, Angus G.; Kokkola, Tarja; Laakso, Markku; Mahajan, Anubha; Mar. 2023. Nature communications. 14: . 5062 A1 Journal article (refereed), original research

Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study

Fernandes Silva, Lilian; Hokkanen, Jenna; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2023. Journal of clinical endocrinology and metabolism. 2024; 109: 100–106 A1 Journal article (refereed), original research

Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Männistö, Ville; Laakso, Markku. 2023. Metabolites. 13: A1 Journal article (refereed), original research

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment

Fernandes Silva, Lilian; Ravi, Rowmika; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2022. Metabolites. 12: A1 Journal article (refereed), original research

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M.; Bentley, Amy R.; Bielak, Lawrence F.; Chong, Mike; Chu, Audrey Y.; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D.; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F.; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M.; Haller, Toomas; Hartwig, Fernando P.; Hillis, David A.; Huikari, Ville; Heard-Costa, Nancy; Hol. 2022. Nature genetics. 54: 1332-1344 A1 Journal article (refereed), original research

Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study

Ravi, Rowmika; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Maria, Maleeha; Raivo, Joose; Helisalmi, Seppo; Laakso, Markku. 2022. Metabolites. 12: A1 Journal article (refereed), original research

Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways

Fernandes Silva, Lilian; Ravi, Rowmika; Vangipurapu, Jagadish; Laakso, Markku. 2022. Metabolites. 12: A1 Journal article (refereed), original research

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Ganel, Liron; Chen, Lei; Christ, Ryan; Vangipurapu, Jagadish; Young, Erica; Das, Indraniel; Kanchi, Krishna; Larson, David; Regier, Allison; Abel, Haley; Kang, Chul Joo; Scott, Alexandra; Havulinna, Aki; Chiang, Charleston WK; Service, Susan; Freimer, Nelson; Palotie, Aarno; Ripatti, Samuli; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku; Locke, Adam; Stitziel, Nathan O; Hall, Ira M. 2021. Human genomics. 15: 1-17 A1 Journal article (refereed), original research

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana et al. [incl. Kokkola, Tarja; Vangipurapu Jagadish; Laakso, Markku; Kuulasmaa, Teemu]. 2021. Diabetes. 70: 2092-2106 A1 Journal article (refereed), original research

The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Laakso, Markku. 2021. Metabolites. 11: 691 A2 Review article, Literature review, Systematic review

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku. 2021. Journal of clinical endocrinology and metabolism. 106: 3448-3454 A1 Journal article (refereed), original research

The trans-ancestral genomic architecture of glycemic traits

Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J]. 2021. Nature genetics. 53: 840-860 A1 Journal article (refereed), original research

A reference map of potential determinants for the human serum metabolome.

Bar, Noam; Korem, Tal; Weissbrod, Omer; Zeevi, David; Rothschild, Daphna; Leviatan, Sigal; Kosower, Noa; Lotan-Pompan, Maya; Weinberger, Adina; Le Roy, Caroline I; Menni, Cristina; Visconti, Alessia; Falchi, Mario; Spector, Tim D; Adamski, Jerzy; Franks, Paul W; Pedersen, Oluf; Segal, Eran; The IMI DIRECT Consortium [incl. Kuulasmaa, Teemu; Kokkola, Tarja; Laakso, Markku; Vangipurapu, Jagadish; Cederberg, Henna]. 2020. Nature. 588: 135-140 A1 Journal article (refereed), original research

Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Smith, Ulf; Laakso, Markku. 2020. Journal of clinical endocrinology and metabolism. 2021; 106: 143-152 A1 Journal article (refereed), original research

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Vangipurapu, Jagadish; Fernandes Silva, Lilian; Kuulasmaa, Teemu; Smith, Ulf; Laakso, Markku. 2020. Diabetes care. 43: 1319-1325 A1 Journal article (refereed), original research

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann. 2020. ESC heart failure. 2021; 8: 605-614 A1 Journal article (refereed), original research

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, Naeimeh; Ohlsson, Mattias; Viñuela, Ana; Frau, Francesca; Pomares-Millan, Hugo; Haid, Mark; Jones, Angus G; Thomas, E Louise; Koivula, Robert W; Kurbasic, Azra; Mutie, Pascal M; Fitipaldi, Hugo; Fernandez, Juan; Dawed, Adem Y; Giordano, Giuseppe N; Forgie, Ian M; McDonald, Timothy J; Rutters, Femke; Cederberg, Henna; Chabanova, Elizaveta et al. [Incl. Kokkola, Tarja; Laakso Markku; Vangipurapu, Jagadish]. 2020. PLoS medicine. 17: e1003149 A1 Journal article (refereed), original research

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

Jääskeläinen, P; Vangipurapu, J; Raivo, J; Kuulasmaa, T; Heliö, T; Aalto-Setälä, K; Kaartinen, M; Ilveskoski, E; Vanninen, S; Hämäläinen, L; Melin, J; Kokkonen, J; Nieminen, MS; FinHCM Study Group; Laakso, M; Kuusisto, J. 2019. ESC heart failure. 6: 436-445 A1 Journal article (refereed), original research

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelou E; Gao, H; Chu, C; Ntritsos, G; Blakeley, P; Butts, AR; Pazoki, R; Suzuki, H; Koskeridis, F; Yiorkas, AM; Karaman, I; Elliott, J; Luo, Q; Aeschbacher, S; Bartz, TM; Baumeister, SE; Braund, PS; Brown, MR; Brody, JA; Clarke TK; et al. (Incl. Yaluri, A; Kuusisto, J; Laakso, M; Vangipurapu, J). 2019. Nature human behaviour. 3: 950-961 A1 Journal article (refereed), original research

Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men

Vangipurapu, J; Stancáková, A; Smith, U; Kuusisto, J; Laakso, M. 2019. Diabetes. 68: 1353-1358 A1 Journal article (refereed), original research

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

López Rodríguez, Maykel; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Modi, Shalem; Kuusisto, Johanna; Kaikkonen, Minna U; Laakso, Markku. 2018. Scientific reports. 8: 15989 A1 Journal article (refereed), original research

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

Huopio Hanna, Miettinen Päivi J, Ilonen Jorma, Nykänen Päivi, Veijola Riitta, Keskinen Päivi, Näntö-Salonen Kirsti, Vangipurapu Jagadish, Raivo Joose, Stancáková Alena, Männistö Jonna, Kuulasmaa Teemu, Knip Mikael, Otonkoski Timo, Laakso Markku. 2016. Journal of clinical endocrinology and metabolism. 101: 3018-3026 A1 Journal article (refereed), original research

Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort

Löf Christoffer, Patyra Konrad, Kuulasmaa Teemu, Vangipurapu Jagadish, Undeutsch Henriette, Jäschke Holger, Pajunen Tuulia, Kero Andreina, Krude Heiko, Biebermann Heike, Kleinau Gunnar, Kühnen Peter, Rantakari Krista, Miettinen Päivi, Kirjavainen Turkka, Pursiheimo Juha-Pekka, Mustila Taina, Jääskeläinen Jarmo, Ojaniemi Marja, Toppari Jorma et al. 2016. Thyroid. 26: 1215-1224 A1 Journal article (refereed), original research

Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men

Vangipurapu Jagadish, Stancakova Alena, Jauhiainen Raimo, Kuusisto Johanna, Laakso Markku. 2016. Journal of clinical endocrinology and metabolism. 2017: 102: 443-450 A1 Journal article (refereed), original research

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Yaghootkar Hanieh, Stancáková Alena, Freathy Rachel M, Vangipurapu Jagadish, Weedon Michael N, Xie Weijia, Wood Andrew R, Ferrannini Ele, Mari Andrea, Ring Susan M, Lawlor Debbie A, Smith George Davey, Jørgensen Torben, Hansen Torben, Pedersen Oluf, Steinthorsdottir Valgerdur, Guðbjartsson Daniel F, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Stefansson Kari et al. 2015. Diabetes. 64: 2279-2285 A1 Journal article (refereed), original research

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men

Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku. 2015. PLoS ONE. 10: e0124028 A1 Journal article (refereed), original research

Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease

Fízelóvá Maria, Cederberg Henna, Stancakova Alena, Jauhiainen Raimo, Vangipurapu Jagadish, Kuusisto Johanna, Laakso Markku. 2014. PLoS ONE. 9: e109772 A1 Journal article (refereed), original research

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes

Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, Schwab U, Kuusisto J, Laakso M. 2013. American journal of clinical nutrition. -: - A1 Journal article (refereed), original research

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Diabetes. 62: 3618-3626 A1 Journal article (refereed), original research

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, Heinonen S, Laakso M. 2013. European journal of endocrinology. 169: 291-297 A1 Journal article (refereed), original research

Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. 2013. Diabetes care. 36: 3732-3738 A1 Journal article (refereed), original research

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. PLoS ONE. 8: e67406 A1 Journal article (refereed), original research

Association between liver insulin resistance and cardiovascular risk factors

Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. 2012. Journal of internal medicine. 272: 402-408 A1 Journal article (refereed), original research

Liver insulin resistance and hyperglycemia: Genetic determinants and association with cardiovascular risk factors

Vangipurapu J. 2012. G5 Doctoral dissertation (article)

A novel surrogate index for hepatic insulin resistance

Vangipurapu J, Stancakova A, Kuulasmaa T, Paananen J, Kuusisto J, EGIR-RISC Study Group, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 540-543 A1 Journal article (refereed), original research

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 563-571 A1 Journal article (refereed), original research

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Jagadish Vangipurapu

Projects

Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Metabolomics-Based Machine Learning for Predicting Mortality: Unveiling Multisystem Impacts on Health

Novel Metabolites Associated with Decreased GFR in Finnish Men: A 12-Year Follow-Up of the METSIM Cohort

Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study

Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study

Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

The trans-ancestral genomic architecture of glycemic traits

A reference map of potential determinants for the human serum metabolome.

Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

An intronic variant in the GCKR gene is associated with multiple lipids

Associations of autozygosity with a broad range of human phenotypes

Exome sequencing of Finnish isolates enhances rare-variant association power

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort

Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men

Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men

Association between liver insulin resistance and cardiovascular risk factors

Liver insulin resistance and hyperglycemia: Genetic determinants and association with cardiovascular risk factors

A novel surrogate index for hepatic insulin resistance

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men