Jari Nissinen

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Epilepsy research. 136: 18-34 A1 Journal article (refereed), original research

Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep

Andrade Pedro, Nissinen Jari, Pitkanen Asla. 2017. Journal of neurotrauma. 34: 1482-1487 A1 Journal article (refereed), original research

Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats

Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Epilepsy research. 2014 May;108(4): 653-65 A1 Journal article (refereed), original research

Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI

Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Journal of neurotrauma. : 546-56 A1 Journal article (refereed), original research

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Epilepsy research. 94: 75-85 A1 Journal article (refereed), original research

Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence

Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Magnetic resonance in medicine. 64: 1191-1199 A1 Journal article (refereed), original research

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A. 2008. Brain. 131: 1506-1515 A1 Journal article (refereed), original research

Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat

Goffin K, Nissinen J, Van Laere K, Pitkänen A. 2007. Experimental neurology. 205: 501-505 A1 Journal article (refereed), original research

Effect of antiepileptic drugs on spontaneous seizures in epileptic rats

Nissinen J, Pitkänen A. 2007. Epilepsy research. 73: 181-191 A1 Journal article (refereed), original research

Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat

Pitkänen A, Mathiesen C, Rønn LCB, Møller A, Nissinen J. 2007. Epilepsy research. 74: 45-54 A1 Journal article (refereed), original research

A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats

Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. Epilepsy research. 72: 25-38 A1 Journal article (refereed), original research

A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats

Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A. 2006. Neuroscience. 140: 685-697 A1 Journal article (refereed), original research

Characterization of a Rat Model of Human Temporal Lobe Epilepsy

Nissinen J. 2006. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti G5 Doctoral dissertation (article)

Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy

Kemppainen EJS, Nissinen J, Pitkänen A. 2006. Epilepsia. 47: 820-829 A1 Journal article (refereed), original research

Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat

Pitkänen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J. 2005. Epilepsy research. 63: 27-42 A1 Journal article (refereed), original research

Cystatin C expression is associated with granule cell dispersion in epilepsy

Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A. 2005. Annals of neurology. 58: 211-223 A1 Journal article (refereed), original research

Epileptic seizure detection: A nonlinear viewpooint

Päivinen N, Lammi S, Pitkänen A, Nissinen J, Penttonen M, Grönfors T. 2005. Computer methods and programs in biomedicine. 79: 151-159 A1 Journal article (refereed), original research

Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats

Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J. 2004. Epilepsy research. 61: 119-140 A1 Journal article (refereed), original research

Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat

Nissinen J, Large CH, Stratton SC, Pitkänen A. 2004. Epilepsy research. 58: 119-132 A1 Journal article (refereed), original research

Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats

Niittykoski M, Nissinen J, Penttonen M, Pitkänen A. 2004. Neuroscience. 124: 269-281 A1 Journal article (refereed), original research

Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy

Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Epilepsia. 45: 1024-1034 A1 Journal article (refereed), original research

Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis

Narkilahti S, Nissinen J, Pitkänen A. 2003. Neuropharmacology. 44: 1068-1088 A1 Journal article (refereed), original research

Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits

Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Epilepsy research. 54: 1-10 A1 Journal article (refereed), original research

Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy

Laurén HB, Pitkänen A, Nissinen J, Soini SL, Korpi ER, Holopainen IE. 2003. Neuroscience letters. 349: 58-62 A1 Journal article (refereed), original research

Decreased BDNF signalling in transgenic mice reduces epileptogenesis

Lähteinen S, Pitkänen A, Saarelainen T, Nissinen J, Koponen E, Castrén E. 2002. European journal of neuroscience. 15: 721-734 A1 Journal article (refereed), original research

Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy

Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. Teoksessa: Sutula T, Pitkänen A(toim.) , 2002. Do Seizures Damage the Brain. s. 67-83. Elsevier A3 Book section, Chapters in research books

Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats

Halonen T, Nissinen J, Pitkänen A. 2001. Neuropharmacology. 40: 536-550 A1 Journal article (refereed), original research

Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat

Halonen T, Nissinen J, Pitkanen A. 2001. Epilepsy research. 46: 205-223 A1 Journal article (refereed), original research

Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?

Nissinen J, Lukasiuk K, Pitkänen A. 2001. Hippocampus. 11: 299-310 A1 Journal article (refereed), original research

A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat

Nissinen J, Halonen T, Koivisto E, Pitkänen A. 2000. Epilepsy research. 38: 177-205 A1 Journal article (refereed), original research

Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy

Pitkänen A, Nissinen J, Lukasiuk K, Jutila L, Paljärvi L, Salmenperä T, Karkola K, Vapalahti M, Ylinen A. 2000. EPILEPSIA. SUPPLEMENT. 41: S24-S29 A1 Journal article (refereed), original research

Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus

Pitkänen A, Nissinen J, Jolkkonen E, Tuunanen J, Halonen T. 1999. Epilepsy research. 33: 67-85 A1 Journal article (refereed), original research

Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat

Halonen T, Nissinen J, Pitkänen A. 1999. Epilepsy research. 34: 251-269 A1 Journal article (refereed), original research

Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system

Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Neuroreport. 7: 2031-2035 A1 Journal article (refereed), original research

Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus

Halonen T, Nissinen J, Jansen JA, Pitkänen A. 1996. European journal of pharmacology. 299: 69-81 A1 Journal article (refereed), original research

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Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep

Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats

Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat

Effect of antiepileptic drugs on spontaneous seizures in epileptic rats

Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat

Epileptogenesis after cortical photothrombotic brain lesion in rats

Epileptogenesis in experimental models

Gene therapy in epilepsy: The focus on NPY

A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats

A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats

Characterization of a Rat Model of Human Temporal Lobe Epilepsy

Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy

Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat

Cystatin C expression is associated with granule cell dispersion in epilepsy

Epileptic seizure detection: A nonlinear viewpooint

Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats

Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat

Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats

Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy

Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis

Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits

Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy

Decreased BDNF signalling in transgenic mice reduces epileptogenesis

Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy

Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats

Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat

Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?

A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat

Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy

Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus

Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat

Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system

Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus