Jenni Lehtisalo

A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol

Barbera, Mariagnese; Lehtisalo, Jenni; Perera, Dinithi; Aspö, Malin; Cross, Mary; De Jager Loots, Celeste A; Falaschetti, Emanuela; Friel, Naomi; Luchsinger, José A; Gavelin, Hanna Malmberg; Peltonen, Markku; Price, Geraint; Neely, Anna Stigsdotter; Thunborg, Charlotta; Tuomilehto, Jaakko; Mangialasche, Francesca; Middleton, Lefkos; Ngandu, Tiia; Solomon, Alina; Kivipelto, Miia; Adeleke, Seliat Adebanke; Arvidsson, Clara; Barton, Isobel; Bas, Mehmet; Cosby, Katrina; Crispin, Jennifer; Dunn, Lucy. 2024. Alzheimer's research and therapy. 16: . 23 A1 Journal article (refereed), original research

Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; Lehtisalo, Jenni; Mangialasche, Francesca; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Stephen, Ruth; Kivipelto, Miia; Solomon, Alina. 2024. Alzheimer's & dementia. [Epub ahead of print 22 April 2024]: 1-6 A1 Journal article (refereed), original research

Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood

Gustavsson, Jonatan; Ištvánfyová, Zuzana; Papenberg, Goran; Falahati, Farshad; Laukka, Erika J; Lehtisalo, Jenni; Mangialasche, Francesca; Kalpouzos, Grégoria. 2024. Neurobiology of aging. 144: 56-67 A1 Journal article (refereed), original research

Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)

Levak, Nicholas; Lehtisalo, Jenni; Thunborg, Charlotta; Westman, Eric; Andersen, Pia; Andrieu, Sandrine; Broersen, Laus M.; Coley, Nicola; Hartmann, Tobias; Irving, Gerd Faxén; Mangialasche, Francesca; Ngandu, Tiia; Pantel, Johannes; Rosenberg, Anna; Sindi, Shireen; Soininen, Hilkka; Solomon, Alina; Wang, Rui; Kivipelto, Miia. 2024. Alzheimer's research and therapy. 16: . 147 A1 Journal article (refereed), original research

Response to “Comment on ‘Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program’”

Wimo, Anders; Handels, Ron; Antikainen, Riitta; Eriksdotter, Maria; Jönsson, Linus; Knapp, Martin; Kulmala, Jenni; Laatikainen, Tiina; Lehtisalo, Jenni; Peltonen, Markku; Sköldunger, Anders; Soininen, Hilkka; Solomon, Alina; Timo Strandberg, T; Tuomilehto, Jaakko; Ngandu, Tiia; Kivipelto, Miia. 2023. Alzheimer's & dementia. 19: 4760-4763 B1 Non-refereed journal articles

The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

Rydstrom, Anders; Stephen, Ruth; Kareholt, Ingemar; Mattsson, Alexander Darin; Ngandu, Tiia; Lehtisalo, Jenni; Backman, Lars; Kemppainen, Nina; Rinne, Juha; Sindi, Shireen; Soininen, Hilkka; Vanninen, Ritva; Solomon, Alina; Mangialasche, Francesca. 2023. Gerontology. 69: 972-985 A1 Journal article (refereed), original research

Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial

Neuvonen, Elisa; Lehtisalo, Jenni; Ngandu, Tiia; Levälahti, Esko; Antikainen, Riitta; Hänninen, Tuomo; Laatikainen, Tiina; Lindström, Jaana; Paajanen, Teemu; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Solomon, Alina. 2022. Journal of clinical medicine. 11: A1 Journal article (refereed), original research

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Wimo, Anders; Handels, Ron; Antikainen, Riitta; Eriksdotter, Maria; Jönsson, Linus; Knapp, Martin; Kulmala, Jenni; Laatikainen, Tiina; Lehtisalo, Jenni; Peltonen, Markku; Sköldunger, Anders; Soininen, Hilkka; Solomon, Alina; Strandberg, Timo; Tuomilehto, Jaakko; Ngandu, Tiia; Kivipelto, Miia. 2022. Alzheimer's & dementia. [First published: 16 July 2022]: 1-10 A1 Journal article (refereed), original research

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

Lehtisalo, Jenni; Rusanen, Minna; Solomon, Alina; Antikainen, Riitta; Laatikainen, Tiina; Peltonen, Markku; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia; Ngandu, Tiia. 2022. European heart journal. 43: 2054–2061 A1 Journal article (refereed), original research

Liikkumisen kannustimet muistisairauksien riskiryhmään kuuluvilla ikääntyneillä

Anttila, Pia; Ngandu, Tiia; Häkkinen, Arja; Lehtisalo, Jenni; Kivipelto, Miia; Kulmala, Jenni. 2022. Gerontologia. 36: 4-15 A1 Journal article (refereed), original research

Multimodal Preventive Trial for Alzheimer’s Disease: MIND-ADmini Pilot Trial Study Design and Progress

Sindi, S; Thunborg, C; Rosenberg, A; Andersen, P; Andrieu, S; Broersen, LM; Coley, N; Couderc, C; Duval, CZ; Faxen-Irving, G; Hagman, G; Hallikainen, M; Håkansson, K; Lehtisalo, J; Levak, N; Mangialasche, F; Pantel, J; Kekkonen, E; Rydström, A; Stigsdotter-Neely, A; Wimo, A; Ngandu, T; Soininen, H; Hartmann, T; Solomon, A; Kivipelto, M. 2022. The Journal of prevention of Alzheimer's disease. 9: 30-39 A1 Journal article (refereed), original research

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Em. 2022. Nature genetics. 54: 412-436 A1 Journal article (refereed), original research

Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial

Neuvonen, Elisa; Lehtisalo, Jenni; Solomon, Alina; Antikainen, Riitta; Havulinna, Satu; Hänninen, Tuomo; Laatikainen, Tiina; Lindström, Jaana; Rautio, Nina; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia. 2022. Aging clinical and experimental research. 34: 1793-1805 A1 Journal article (refereed), original research

Changes in Lifestyle, Behaviors, and Risk Factors for Cognitive Impairment in Older Persons During the First Wave of the Coronavirus Disease 2019 Pandemic in Finland: Results From the FINGER Study

Lehtisalo, Jenni; Palmer, Katie; Mangialasche, Francesca; Solomon, Alina; Kivipelto, Miia; Ngandu, Tiia. 2021. Frontiers in psychiatry. 12: 624125 A1 Journal article (refereed), original research

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; et al; [incl. Haapasalo, A; Soininen, H; Lehtisalo, J; Kivipelto, M; Kuulasmaa, T; Hiltunen, M]. 2021. Nature communications. 12: 3417 A1 Journal article (refereed), original research

Development of the First WHO Guidelines for Risk Reduction of Cognitive Decline and Dementia: Lessons Learned and Future Directions

Stephen, Ruth; Barbera, Mariagnese; Peters, Ruth; Ee, Nicole; Zheng, Lidan; Lehtisalo, Jenni; Kulmala, Jenni; Håkansson, Krister; Chowdhary, Neerja; Dua, Tarun; Solomon, Alina; Anstey, Kaarin J; Kivipelto, Miia. 2021. Frontiers in neurology. 12: 763573 A2 Review article, Literature review, Systematic review

Muistisairaudet

Lehtisalo, Jenni; Kivipelto, Miia; Ngandu, Tiia; Eskelinen, Marjo; Soininen, Hilkka. Teoksessa: Mutanen, Marja; Niinikoski, Harri; Schwab, Ursula; Uusitupa, Matti(toim.) , 2021. Ravitsemustiede (8. uud. painos). s. 461-466. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Sex and gender differences in genetic and lifestyle risk and protective factors for dementia

Sindi, Shireen; Toopchiani, Sima; Barbera, Mariagnese; Håkansson, Krister; Lehtisalo, Jenni; Rosenberg, Anna; Stephen, Ruth; Udeh-Momoh, Chinedu; Kivipelto, Miia. Teoksessa: Ferretti, Maria Teresa; Schumacher Dimech, Annemarie; Santuccione Chadha, Antonella(toim.) , 2021. Sex and Gender Differences in Alzheimer's Disease. s. 269-308. Academic press B2 Book section

Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial

Sindi, Shireen; Solomon, Alina; Kåreholt, Ingemar; Hovatta, Iiris; Antikainen, Riitta; Hänninen, Tuomo; Levälahti, Esko; Laatikainen, Tiina; Lehtisalo, Jenni; Lindström, Jaana; Paajanen, Teemu; Peltonen, Markku; Singh Khalsa, Dharma; Wolozin, Benjamin; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Ngandu, Tiia; Kivipelto, Miia; for the FINGER Study Group. 2021. Journals of gerontology series a: biological sciences and medical sciences. 76: 491-498 A1 Journal article (refereed), original research

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Ngandu, Tiia; Lehtisalo, Jenni; Korkki, Saana; Solomon, Alina; Coley, Nicola; Antikainen, Riitta; Bäckman, Lars; Hänninen, Tuomo; Lindström, Jaana; Laatikainen, Tiina; Paajanen, Teemu; Havulinna, Satu; Peltonen, Markku; Neely, Anna Stigsdotter; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia. 2021. Alzheimer's & dementia. First published: 20 October 2021: 1 - 10 A1 Journal article (refereed), original research

Earlier life leisure-time physical activity in relation to age-related frailty syndrome

Kolehmainen, L; Havulinna, S; Ngandu, T; Strandberg, T; Levälahti, E; Lehtisalo, J; Antikainen, R; Hietikko, E; Peltonen, M; Pölönen, A; Soininen, H; Tuomilehto, J; Laatikainen, T; Rauramaa, R; Kivipelto, M; Kulmala, J. 2020. Age and ageing. 2021; 50: 161-168 A1 Journal article (refereed), original research

Muistisairauksien ehkäisy osaksi ikääntyvien terveyden edistämistä

Lehtisalo, Jenni; Kulmala, Jenni; Ngandu, Tiia; Kivipelto, Miia. 2020. Ravitsemusasiantuntija. 6: 14-17 D1 Article in a trade journal

Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol

Barbera, Mariagnese; Kulmala, Jenni; Lisko, Inna; Pietilä, Eija; Rosenberg, Anna; Hallikainen, Ilona; Hallikainen, Merja; Laatikainen, Tiina; Lehtisalo, Jenni; Neuvonen, Elisa; Rusanen, Minna; Soininen, Hilkka; Tuomilehto, Jaakko; Ngandu, Tiia; Solomon, Alina; Kivipelto, Miia. 2020. Bmc geriatrics. 20: 238 A1 Journal article (refereed), original research

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

Kivipelto, M; Mangialasche, F; Snyder, HM; Allegri, R; Andrieu, S; Arai, H; Baker, L; Belleville, S; Brodaty, H; Brucki, SM; Calandri, I; Caramelli, P; Chen, C; Chertkow, H; Chew, E; Choi, SH; Chowdhary, N; Crivelli, L; De La Torre, R; Du, Y; et al. [Incl. Lehtisalo, J; Rosenberg, A; Soininen, H; Solomon, A]. 2020. Alzheimer's & dementia. 16: 1078-1094 A1 Journal article (refereed), original research

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Publications

A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol

Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood

Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)

Response to “Comment on ‘Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program’”

The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial

Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

Liikkumisen kannustimet muistisairauksien riskiryhmään kuuluvilla ikääntyneillä

Multimodal Preventive Trial for Alzheimer’s Disease: MIND-ADmini Pilot Trial Study Design and Progress

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial

Changes in Lifestyle, Behaviors, and Risk Factors for Cognitive Impairment in Older Persons During the First Wave of the Coronavirus Disease 2019 Pandemic in Finland: Results From the FINGER Study

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Development of the First WHO Guidelines for Risk Reduction of Cognitive Decline and Dementia: Lessons Learned and Future Directions

Muistisairaudet

Sex and gender differences in genetic and lifestyle risk and protective factors for dementia

Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial

The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Earlier life leisure-time physical activity in relation to age-related frailty syndrome

Muistisairauksien ehkäisy osaksi ikääntyvien terveyden edistämistä

Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia