Johanna Jyrkkärinne - UEFConnect

Refine your search

Information Publications

Publications

13/13 items

An update on the constitutive androstane receptor (CAR)
Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo, 2013, Drug metabolism and drug interactions, 28, 2, 79-93. A2 Review article, Literature review, Systematic review
Molecular dynamics simulations for human CAR inverse agonists
Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo, 2012, Journal of chemical information and modeling, 52, 457-464. A1 Journal article (refereed), original research
New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists
Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo, 2011, Molecular pharmaceutics, 8, 2424-2433. A1 Journal article (refereed), original research
Use of comprehensive screening methods to detect selective human CAR activators
Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand, 2011, Biochemical pharmacology, 82, 1994-2007. A1 Journal article (refereed), original research
Functional and Structural Studies on the Nuclear Receptor CAR
Jyrkkärinne Johanna, 2010, Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. G5 Doctoral dissertation (article)
Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor
Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B, 2008, Biochemical pharmacology, 76, 1288-1297. A1 Journal article (refereed), original research
Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship
Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P, 2008, Journal of medicinal chemistry, 51, 7181-7192. A1 Journal article (refereed), original research
Ligand specificity of constitutive androstane receptor as probed by induced-fit drocking and mutagenesis
Repo S, Jyrkkärinne J, Pulkkinen JT, Laatikainen R, Honkakoski P, Johnson MS, 2008, Journal of medicinal chemistry, 51, 7119-7131. A1 Journal article (refereed), original research
Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity
Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W, 2007, Journal of molecular graphics and modelling, 25, 644-657. A1 Journal article (refereed), original research
Amino acids important for ligand specificity of the human constitutive androstane receptor
Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, Peräkylä M, Poso A, Sippl W, Honkakoski P, 2005, Journal of biological chemistry, 280, 7, 5960-5971. A1 Journal article (refereed), original research
Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity
Windshügel B, Jyrkkärinne J, Poso A, Honkakoski P, Sippl W, 2004, Journal of molecular modeling. A1 Journal article (refereed), original research
Dual action of oestrogens on the mouse constitutive androstane receptor
Mäkinen J, Reinisalo M, Niemi K, Viitala P, Jyrkkärinne J, Chung H, Pelkonen O, Honkakoski P, 2003, Biochemical journal, 376, 465-472. A1 Journal article (refereed), original research
Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor
Jyrkkärinne J, Mäkinen J, Gynther J, Savolainen H, Poso A, Honkakoski P, 2003, Journal of medicinal chemistry, 46, 4687-4695. A1 Journal article (refereed), original research