We are utilizing hiPSC cells to model Parkinson’s disease (LRRK2 G2019S-mutation). My focus is in PD related neuroinflammation and the effect of aggregated alphasynuclein fibrils on glial cells. I study specifically microglia cells and how the changes in the functions of these immune cells affect the motorneuron function and wellbeing.
Research groups
Publications
9/9 items-
Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis
Abdolahpur Monikh, Fazel; Lehtonen, Šárka; Kekäläinen, Jukka; Karkossa, Isabel; Auriola, Seppo; Schubert, Kristin; Zanut, Alessandra; Peltonen, Sanni; Niskanen, Jonna; Bandekar, Mandar; von Bergen, Martin; Leskinen, Jari TT; Koistinen, Arto; Bogialli, Sara; Guo, Zhiling; Kukkonen, Jussi VK; Chen, Chunying; Lynch, Iseult. 2024. Nano today. 59: . 102466 A1 Journal article (refereed), original research -
Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells
Peltonen, Sanni; Sonninen, Tuuli-Maria; Niskanen, Jonna; Koistinaho, Jari; Ruponen, Marika; Lehtonen, Šárka. 2024. Fluids and barriers of the cns. 21: . 92 A1 Journal article (refereed), original research -
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka. 2024. Glia. [First published: 22 October 2024]: 1-16 A1 Journal article (refereed), original research -
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2023. Scientific reports. 13: . 22118 A1 Journal article (refereed), original research -
Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study
Albert, Katrina; Kälvälä, Sara; Hakosalo, Vili; Syvänen, Valtteri; Krupa, Patryk; Niskanen, Jonna; Peltonen, Sanni; Sonninen, Tuuli-Maria; Lehtonen, Šárka. 2022. Biomedicines. 10: A2 Review article, Literature review, Systematic review -
Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
Saran, Chitra; Sundqvist, Louise; Ho, Henry; Niskanen, Jonna; Honkakoski, Paavo; Brouwer, Kim LR. 2022. Journal of pharmacology and experimental therapeutics. 380: 114-125 A1 Journal article (refereed), original research -
Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
Albert, Katrina; Niskanen, Jonna; Kälvälä, Sara; Lehtonen, ¦árka. 2021. International journal of molecular sciences. 22: 4334 A2 Review article, Literature review, Systematic review -
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. 2020. Cells. 9: 2306 A2 Review article, Literature review, Systematic review -
The EDCMET project: Metabolic effects of endocrine disruptors
Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. International journal of molecular sciences. 21: 3021 A1 Journal article (refereed), original research