Joonas Kosonen
Postdoctoral Researcher
Department of Technical Physics, Faculty of Science, Forestry and Technology
[email protected] | +358 50 341 5875
One of the hallmarks of osteoarthritis is cartilage degeneration, which is partly caused by cartilage cells. However, the cellular mechanisms that promote degeneration and the factors that trigger them are poorly understood. My doctoral thesis investigated how different cellular mechanisms contribute to the degeneration of damaged cartilage and the progression of osteoarthritis. My postdoctoral project focuses on expanding the models developed in my doctoral thesis to also take into account intracellular signaling in cartilage degeneration. In addition, the project simulates the effect of drugs on cell signaling and cartilage tissue degeneration
Research groups
Publications
6/6 items-
Cell-driven in silico modeling of post-traumatic osteoarthritis : Impact of Overloading, Inflammation, and Antioxidant Treatment on articular cartilage composition
Kosonen, Joonas, 2025, Publications of the University of Eastern Finland. Dissertations in Science, Forestry and Technology. G5 Doctoral dissertation (article) -
Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage
Kosonen, Joonas P; Eskelinen, Atte S A; Orozco, Gustavo A.; Coleman, Mitchell C; Goetz, Jessica E; Anderson, Donald D; Grodzinsky, Alan J; Tanska, Petri; Korhonen, Rami K, 2025, Biomechanics and modeling in mechanobiology, 24, 4, 1191-1206, . A1 Journal article (refereed), original research -
Positive effects of acute N-acetylcysteine treatment simulated by an in silico model with overloading induced cell damage and recovery mechanisms
Kosonen, Joonas; Eskelinen, Atte; Orozco, Gustavo; Goetz, Jessica; Coleman, Mitchell; Grodzinsky, Alan; Anderson, Donald; Tanska, Petri; Korhonen, Rami, 2024, Annual meeting of the orthopaedic research society. Abstract -
Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines
Kosonen, Joonas P.; Eskelinen, Atte S. A; Orozco, Gustavo A.; Nieminen, Petteri; Anderson, Donald D; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri, 2023, PLoS computational biology, 19, 1, e1010337. A1 Journal article (refereed), original research -
Reduction of pro-inflammatory cytokine activity results in proteoglycan content recovery in a computational model of injured articular cartilage implementing cytokines and reactive oxygen species
Kosonen, Joonas; Eskelinen, Atte; Orozco, Gustavo; Anderson, Donald; Grodzinsky, Alan; Tanska, Petri; Korhonen, Rami, 2022, Orthopaedic Research Society. Abstract -
Shear strain and inflammation-induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study
Orozco, Gustavo A; Eskelinen, Atte SA; Kosonen, Joonas P; Tanaka, Matthew S; Yang, Mingrui; Link, Thomas M; Ma, Benjamin; Li, Xiaojuan; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri, 2021, Journal of orthopaedic research, [Epub ahead of print 17 Sept 2021], 1-18, . A1 Journal article (refereed), original research