Juha Savinainen
University Lecturer
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
Research groups
Publications
50/50 items-
Differential inhibitory effects of endocannabinoids on neuronal firing of mouse meningeal afferents
Krivoshein, Georgii; Della Pietra, Adriana; Savinainen, Juha; van den Maagdenberg, Arn MJM; Giniatullin, Rashid, 2025, Journal of headache and pain, 26, 1, 112. A1 Journal article (refereed), original research -
Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression
Brugia, Flavia; Ivanov, Konstantin; Aroviita, Auni; Giniatullina, Raisa; Lehtonen, Marko; Malm, Tarja; Savinainen, Juha; Giniatullin, Rashid; Della Pietra, Adriana, 2025, Journal of headache and pain, 26, 1, 85. A1 Journal article (refereed), original research -
Synovial fluid o-tyrosine is a potential biomarker for autoimmune-driven rheumatoid arthritis
Mustonen, Anne-Mari; Savinainen, Juha; Lehtonen, Marko; Lehenkari, Petri; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Nieminen, Petteri, 2025, Clinical rheumatology, 44, 7, 2657-2668. A1 Journal article (refereed), original research -
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
Pätsi, Henri T; Kilpeläinen, Tommi P; Jumppanen, Mikael; Uhari-Väänänen, Johanna; Wielendaele, Pieter Van; De Lorenzo, Francesca; Cui, Hengjing; Auno, Samuli; Saharinen, Janne; Seppälä, Erin; Sipari, Nina; Savinainen, Juha; De Meester, Ingrid; Lambeir, Anne-Marie; Lahtela-Kakkonen, Maija; Myöhänen, Timo T; Wallén, Erik AA, 2024, Journal of medicinal chemistry, 67, 7, 5421-5436. A1 Journal article (refereed), original research -
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy
Eteläinen, Tony S; Silva, M Catarina; Uhari-Väänänen, Johanna K; De Lorenzo, Francesca; Jäntti, Maria H; Cui, Hengjing; Chavero-Pieres, Marta; Kilpeläinen, Tommi; Mechtler, Christina; Svarcbahs, Reinis; Seppälä, Erin; Savinainen, Juha R; Puris, Elena; Fricker, Gert; Gynther, Mikko; Julku, Ulrika H; Huttunen, Henri J; Haggarty, Stephen J; Myöhänen, Timo T, 2023, Science translational medicine, 15, 691, 1-17. A1 Journal article (refereed), original research -
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid, 2023, Journal of headache and pain, 24, 1, 38. A1 Journal article (refereed), original research -
Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β Hydrolase Domain 6 (ABHD6)
Mardon, Karine; Patel, Jayendra Z; Savinainen, Juha R; Stimson, Damion HR; Oyagawa, Caitlin RM; Grimsey, Natasha L; Migotto, Mary-anne; Njiru, Grace FM; Hamilton, Brett R; Cowin, Gary; Yli-Kauhaluoma, Jari; Vanduffel, Wim; Blakey, Idriss; Bhalla, Rajiv; Cawthorne, Christopher; Celen, Sofie; Bormans, Guy; Thurecht, Kristofer J; Ahamed, Muneer, 2023, Journal of medicinal chemistry, 66, 1, 538-552. A1 Journal article (refereed), original research -
Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain
Della Pietra, Adriana; Savinainen, Juha; Giniatullin, Rashid, 2022, International journal of molecular sciences, 23, 8, 4407. A2 Review article, Literature review, Systematic review -
Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis
Nieminen, Petteri; Hämäläinen, Wilhelmiina; Savinainen, Juha; Lehtonen, Marko; Lehtiniemi, Saara; Rinta-Paavola, Juho; Lehenkari, Petri; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Mustonen, Anne-Mari, 2022, Inflammation, 45, 3, 1101-1117. A1 Journal article (refereed), original research -
Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine
Della Pietra, Adriana; Giniatullin, Rashid; Savinainen, Juha R, 2021, International journal of molecular sciences, 22, 3, 1204. A1 Journal article (refereed), original research