Juha Savinainen
University Lecturer
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
juha.savinainen@uef.fi | +358 40 355 3696
Research groups
Publications
47/47 items-
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
Pätsi, Henri T; Kilpeläinen, Tommi P; Jumppanen, Mikael; Uhari-Väänänen, Johanna; Wielendaele, Pieter Van; De Lorenzo, Francesca; Cui, Hengjing; Auno, Samuli; Saharinen, Janne; Seppälä, Erin; Sipari, Nina; Savinainen, Juha; De Meester, Ingrid; Lambeir, Anne-Marie; Lahtela-Kakkonen, Maija; Myöhänen, Timo T; Wallén, Erik AA. 2024. Journal of medicinal chemistry. 67: 5421-5436 A1 Journal article (refereed), original research -
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy
Eteläinen, Tony S; Silva, M Catarina; Uhari-Väänänen, Johanna K; De Lorenzo, Francesca; Jäntti, Maria H; Cui, Hengjing; Chavero-Pieres, Marta; Kilpeläinen, Tommi; Mechtler, Christina; Svarcbahs, Reinis; Seppälä, Erin; Savinainen, Juha R; Puris, Elena; Fricker, Gert; Gynther, Mikko; Julku, Ulrika H; Huttunen, Henri J; Haggarty, Stephen J; Myöhänen, Timo T. 2023. Science translational medicine. 15: 1-17 A1 Journal article (refereed), original research -
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38 A1 Journal article (refereed), original research -
Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β Hydrolase Domain 6 (ABHD6)
Mardon, Karine; Patel, Jayendra Z; Savinainen, Juha R; Stimson, Damion HR; Oyagawa, Caitlin RM; Grimsey, Natasha L; Migotto, Mary-anne; Njiru, Grace FM; Hamilton, Brett R; Cowin, Gary; Yli-Kauhaluoma, Jari; Vanduffel, Wim; Blakey, Idriss; Bhalla, Rajiv; Cawthorne, Christopher; Celen, Sofie; Bormans, Guy; Thurecht, Kristofer J; Ahamed, Muneer. 2023. Journal of medicinal chemistry. 66: 538-552 A1 Journal article (refereed), original research -
Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain
Della Pietra, Adriana; Savinainen, Juha; Giniatullin, Rashid. 2022. International journal of molecular sciences. 23: A2 Review article, Literature review, Systematic review -
Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis
Nieminen, Petteri; Hämäläinen, Wilhelmiina; Savinainen, Juha; Lehtonen, Marko; Lehtiniemi, Saara; Rinta-Paavola, Juho; Lehenkari, Petri; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Mustonen, Anne-Mari. 2022. Inflammation. 45: 1101-1117 A1 Journal article (refereed), original research -
Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine
Della Pietra, Adriana; Giniatullin, Rashid; Savinainen, Juha R. 2021. International journal of molecular sciences. 22: 1204 A1 Journal article (refereed), original research -
Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells
Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha. 2020. European journal of pharmaceutical sciences. 149: 105321 A1 Journal article (refereed), original research -
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo. 2020. Biological procedures online. 22: 6 A1 Journal article (refereed), original research -
Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications
Grimsey, NL; Savinainen, JR; Attili, B; Ahamed, M. 2020. Drug discovery today. 25: 330-343 A2 Review article, Literature review, Systematic review