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Jukka Lipponen

Jukka Lipponen

Visiting Researcher

Department of Technical Physics, Faculty of Science, Forestry and Technology

[email protected] | +358 40 355 3867

Information Publications

Jukka A. Lipponen, Ph.D, received his PhD degree (Medical Physics) in 2014 and M.Sc. (Information technology) in 2007 at the University of Eastern Finland. During his research career (2007-2016) he has been project manager of several scientific projects. His current research interest includes medical signal analysis, data analysis and medical device development. The main research applications include cardiovascular health and cardiovascular disease diagnostics.

He is currently working on Heart2Save Oy, where he is been principal developer of arrythmia monitoring algorithms, which are the core of the Heart2Save’s Aivoni arrythmia analysis service. Jukka Lipponen is also the co-founder of Kubios Oy, start-up company providing HRV and other biomedical signal analysis software tools for researchers and consumers.

Publications

53/53 items

Autonomic responses to tooth clenching and handgrip test
Tapiainen, Atte A; Zaproudina, Nina; Lipponen, Jukka A; Tarvainen, Mika P; Vierola, Anu; Rissanen, Saara M; Karjalainen, Pasi A; Närhi, Matti. 2022. Acta odontologica scandinavica. 80: 389-395 A1 Journal article (refereed), original research
Continuous 24-h Photoplethysmogram Monitoring Enables Detection of Atrial Fibrillation
Väliaho, Eemu-Samuli; Lipponen, Jukka A; Kuoppa, Pekka; Martikainen, Tero J; Jäntti, Helena; Rissanen, Tuomas T; Castrén, Maaret; Halonen, Jari; Tarvainen, Mika P; Laitinen, Tiina M; Laitinen, Tomi P; Santala, Onni E; Rantula, Olli; Naukkarinen, Noora S; Hartikainen, Juha EK. 2022. Frontiers in physiology. 12: . 778775 A1 Journal article (refereed), original research
Continuous mHealth Patch Monitoring for the Algorithm-Based Detection of Atrial Fibrillation: Feasibility and Diagnostic Accuracy Study
Santala, Onni E; Lipponen, Jukka A; Jäntti, Helena; Rissanen, Tuomas T; Tarvainen, Mika P; Laitinen, Tomi P; Laitinen, Tiina M; Castrén, Maaret; Väliaho, Eemu-Samuli; Rantula, Olli A; Naukkarinen, Noora S; Hartikainen, Juha E K; Halonen, Jari; Martikainen, Tero J. 2022. JMIR cardio. 6: A1 Journal article (refereed), original research
Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history
Ebrahimian, Serajeddin; Sillanmäki, Saara; Hietakoste, Salla; Duce, Brett; Kulkas, Antti; Töyräs, Juha; Leppänen, Timo; Lipponen, Jukka A.; Kainulainen, Samu. 2022. PLoS ONE. 17: A1 Journal article (refereed), original research
Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals
Klumpp, Matthias; Hintze, Marcus; Immonen, Milla; Ródenas-Rigla, Francisco; Pilati, Francesco; Aparicio-Martínez, Fernando; Çelebi, Dilay; Liebig, Thomas; Jirstrand, Mats; Urbann, Oliver; Hedman, Marja; Lipponen, Jukka A.; Bicciato, Silvio; Radan, Anda-Petronela; Valdivieso, Bernardo; Thronicke, Wolfgang; Gunopulos, Dimitrios; Delgado-Gonzalo, Ricard. 2021. Healthcare. 9: 961 A1 Journal article (refereed), original research
Necklace-embedded electrocardiogram for the detection and diagnosis of atrial fibrillation
Santala, Onni E; Lipponen, Jukka A; Jäntti, Helena; Rissanen, Tuomas T; Halonen, Jari; Kolk, Indrek; Pohjantähti-Maaroos, Hanna; Tarvainen, Mika P; Väliaho, Eemu-Samuli; Hartikainen, Juha; Martikainen, Tero. 2021. Clinical cardiology. 44: 620-626 A1 Journal article (refereed), original research
Wrist Band Photoplethysmography Autocorrelation Analysis Enables Detection of Atrial Fibrillation Without Pulse Detection
Väliaho, Eemu-Samuli; Kuoppa, Pekka; Lipponen, Jukka A; Hartikainen, Juha EK; Jäntti, Helena; Rissanen, Tuomas T; Kolk, Indrek; Pohjantähti-Maaroos, Hanna; Castrén, Maaret; Halonen, Jari; Tarvainen, Mika P.; Santala, Onni E.; Martikainen, Tero J.. 2021. Frontiers in physiology. 12: 654555 A1 Journal article (refereed), original research
A robust algorithm for heart rate variability time series artefact correction using novel beat classification
Lipponen, JA; Tarvainen, MP. 2019. Journal of medical engineering and technology. 43: 173-181 A1 Journal article (refereed), original research
Effectiveness of the Chest Strap Electrocardiogram to Detect Atrial Fibrillation
Hartikainen, S; Lipponen, JA; Hiltunen, P; Rissanen, TT; Kolk, I; Tarvainen, MP; Martikainen, TJ; Castren, M; Väliaho, ES; Jäntti, H. 2019. American journal of cardiology. 123: 1643-1648 A1 Journal article (refereed), original research
Recovery from sauna bathing favorably modulates cardiac autonomic nervous system
Laukkanen, Tanjaniina; Lipponen, Jukka; Kunutsor, Setor K; Zaccardi, Francesco; Araújo, Claudio Gil S; Mäkikallio, Timo H; Khan, Hassan; Willeit, Peter; Lee, Earric; Poikonen, Sanna; Tarvainen, Mika; Laukkanen, Jari A. 2019. Complementary therapies in medicine. 45: 190-197 A1 Journal article (refereed), original research
Terveelliset välipalat parantavat ikäihmisten ravitsemustilaa
Törönen, Riitta; Nykänen, Irma; Lipponen, Jukka; Tarvainen, Mika; Schwab, Ursula. 2019. Kehittyvä Elintarvike. 30: 45 D1 Article in a trade journal
Wrist band photoplethysmography in detection of individual pulses in atrial fibrillation and algorithm-based detection of atrial fibrillation
Väliaho, ES; Kuoppa, P; Lipponen, JA; Martikainen, TJ; Jäntti, H; Rissanen, TT; Kolk, I; Castrén, M; Halonen, J; Tarvainen, MP; Hartikainen, JEK. 2019. Europace. 21: 1031-1038 A1 Journal article (refereed), original research
Autonomic responses to tooth clenching in migraineurs - augmented trigeminocardiac reflex?
Zaproudina, Nina; Lipponen, Jukka A; Tarvainen, Mika P; Vierola, Anu; Rissanen, Saara M; Karjalainen, Pasi A; Närhi, Matti. 2018. Journal of oral rehabilitation. 45: 764-769 A1 Journal article (refereed), original research
Electrical and mechanical dyssynchrony in patients with right bundle branch block
Sillanmäki, Saara; Aapro, Sini; Lipponen, Jukka A; Tarvainen, Mika P; Laitinen, Tiina; Hedman, Marja; Hämäläinen, Hanna; Laitinen, Tomi. 2018. Journal of nuclear cardiology. [First Online: 24 August 2018]: 1-10 A1 Journal article (refereed), original research
Global electrical heterogeneity as a predictor of cardiovascular mortality in men and women
Lipponen, JA; Kurl, S; Laukkanen, JA. 2018. Europace. 20: 1841-1848 A1 Journal article (refereed), original research
Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls
Sillanmäki, S; Lipponen, JA; Tarvainen, MP; Laitinen, T; Hedman, M; Hedman, A; Kivelä, A; Hämäläinen, H; Laitinen, T. 2018. Journal of nuclear cardiology. 2019; 26: 1228-1239 A1 Journal article (refereed), original research
Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs
Zaproudina, Nina; Rissanen, Antti-Pekka E; Lipponen, Jukka A; Vierola, Anu; Rissanen, Saara M; Karjalainen, Pasi A; Soinila, Seppo; Närhi, Matti. 2018. Frontiers in neurology. 9: 1112 A1 Journal article (refereed), original research
Analysis and Preprocessing of HRV-Kubios HRV Software
Tarvainen, Mika P; Lipponen, Jukka A; Kuoppa, Pekka. Teoksessa: Jelinek, Herbert F; Cornforth, David J; Kahndoker, Ashan H(toim.) , 2017. CG Time Series Variability Analysis. s. 1-28. CRC press A3 Book section, Chapters in research books
Heart Rate Variability During Cardiorespiratory Exercise Test in Type 1 Diabetes
Tarvainen Mika P, Nikkonen Sami, Peltonen Juha E, Aho Jyrki M, Koponen Anne S, Lipponen Jukka A, Rissanen Antti-Pekka E, Tikkanen Heikki O. Teoksessa: Eskola Hannu, Väisänen Outi, Viik Jari, Hyttinen Jari(toim.) , 2017. EMBEC & NBC 2017. s. 181-184. Springer A4 Conference proceedings
Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice
Merentie M, Lipponen JA, Hedman M, Hedman A, Hartikainen J, Huusko J, Lottonen-Raikaslehto L, Parviainen V, Laidinen S, Karjalainen PA, Ylä-Herttuala S. 2015. Psychological reports. 3: e12639 A1 Journal article (refereed), original research
Beat to beat estimation of cosRT angle and cosRT RR hysteresis from exercise ECG measurement
Lipponen JA, Tarvainen MP. Teoksessa: das Neves R.C.(toim.) , 2014. INSTICC Press. s. 22-26. A4 Conference proceedings
Cardiac autonomic dysfunction in type 2 diabetes - effect of hyperglycemia and disease duration
Tarvainen Mika P, Laitinen Tomi P, Lipponen Jukka A, Cornforth David J, Jelinek Herbert F. 2014. Frontiers in endocrinology. 5: 130 A1 Journal article (refereed), original research
Estimation Methods for Cardiovascular Signal Analysis
Lipponen Jukka. 2014. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences G5 Doctoral dissertation (article)
Heart rate variability evaluation of Emfit sleep mattress breathing categories in NREM sleep
Tenhunen M, Hyttinen J, Lipponen J, Virkkala J, Kuusimäki S, Tarvainen MP, Karjalainen PA, Himanen S-L. 2014. Clinical neurophysiology. Epub ahead of print: - A1 Journal article (refereed), original research
Principal component model for maternal ECG extraction in fetal QRS detection
Lipponen Jukka A, Tarvainen Mika P. 2014. Physiological measurement. 35: 1637-1648 A1 Journal article (refereed), original research
Acral coldness in migraineurs
Zaproudina N, Lipponen JA, Karjalainen PA, Kamshilin AA, Giniatullin R, Närhi M. 2013. Autonomic neuroscience: basic and clinical. [Epub ahead of print]: - A1 Journal article (refereed), original research
Advanced Maternal ECG Removal and Noise Reduction for Application of Fetal QRS Detection
Lipponen JA, Tarvainen MP. Teoksessa: Computing in Cardiology(toim.) , 2013. Computing in Cardiology 2013, Volume 40. s. 161-165. A4 Conference proceedings
Asynchronicity of facial blood perfusion in migraine
N. Zaproudina, V. Teplov, E. Nippolainen, J. A. Lipponen, A. A. Kamshilin, M. Närhi, P. A. Karjalainen, and R. Giniatullin. 2013. PLoS ONE. 8: e80189 A1 Journal article (refereed), original research
Causal estimation of neural and overall baroreflex sensitivity in relation to carotid artery stiffness
Lipponen JA, Tarvainen MP, Laitinen T, Karjalainen PA, Vanninen J, Koponen T, Laitinen TM. 2013. Physiological measurement. 34: 1633-1644 A1 Journal article (refereed), original research
Complexity of heart rate variability in type 2 diabetes - effect of hyperglycemia
Tarvainen MP, Cornforth D, Kuoppa P, Lipponen J, Jelinek H. Teoksessa: -(toim.) , 2013. 35th Annual International Conference of the IEEE EMBS. s. 5558-5561. A4 Conference proceedings
Dynamic Modeling of Respiratory Sinus Arrhythmia Component from HRV with Multivariate Kalman Smoother
Kuoppa Pekka, Lipponen Jukka, Tarvainen Mika. Teoksessa: -(toim.) , 2013. Proceedings of the 35th Annual International Conference of the IEEE EMBS. s. 1684-1687. A4 Conference proceedings
Kubios HRV - Heart rate variability analysis software
Tarvainen MP, Niskanen J-P, Lipponen JA, Ranta-aho PO, and Karjalainen PA. 2013. Computer methods and programs in biomedicine. 113: 210-220 A1 Journal article (refereed), original research
Nitroglycerin-induced changes in facial skin temperature: 'cold nose' as a predictor of headache?
Zaproudina N, Närhi M, Lipponen JA, Tarvainen MP, Karjalainen PA, Karhu J, Airaksinen O, Giniatullin R. 2013. Clinical physiology and functional imaging. 33: 409-417 A1 Journal article (refereed), original research
The correlation of vectorcardiographic changes to blood lactate concentration during an exercise test
Lipponen JA, Gladwell VF, Kinnunen H, Karjalainen PA, Tarvainen MP. 2013. Biomedical signal processing and control. 8: 491-499 A1 Journal article (refereed), original research
Effect of hyperglycemia on cardiac autonomic function in type 2 diabetes
Tarvainen MP, Lipponen J, Al-Aubaidy H, Jelinek H. Teoksessa: Murray A(toim.) , 2012. Computing in Cardiology. s. 405-408. A4 Conference proceedings
Estimation of arterial baroreflex sensitivity in relation to carotid artery stiffness
Lipponen JA, Tarvainen MP, Laitinen T, Karjalainen PA, Vanninen J, Koponen T and Lyyra-Laitinen T. Teoksessa: Khoo MCK, Cauwenberghs G, Weiland JD and Chien S(toim.) , 2012. Proceedings of the 34th Annual International Conference of the IEEE EMBS. s. 3408-3411. A4 Conference proceedings
Heart rate variability dynamics during low-dose propofol and dexmedetomidine anesthesia
Tarvainen MP, Georgiadis S, Laitio T, Lipponen JA, Karjalainen PA, Kaskinoro K, Scheinin H. 2012. Annals of biomedical engineering. 40: 1802-1813 A1 Journal article (refereed), original research
Cholesterol metabolism, endothelial dysfunction, and carotid artery stiffness in type 1 diabetes
Koponen Timo, Hallikainen Maarit, Lipponen Jukka, Lyyra-Laitinen Tiina, Karjalainen Pasi A., Tarvainen Mika P., Sittiwet Chaiyasit, Miettinen Tatu A., Laitinen Tomi, Gylling Helena. 2011. Artery research. 5: 8-14 A1 Journal article (refereed), original research
Continuous analysis of repolarization characteristics during insulin induced hypoglycemia
Lipponen JA, Karjalainen PA, Kemppainen J, Mikola H, Kärki T, Laitinen T ,Tarvainen MP. Teoksessa: SciTePress - Science and Technology Publications(toim.) , 2011. Proceedings of the International Conference on Bio-inspired Systems and Signal Processing. s. 107-111. A4 Conference proceedings
Dynamic estimation of cardiac repolarization characteristics during hypoglycemia in healthy and diabetic subjects.
Lipponen JA, Kemppainen J, Karjalainen PA, Laitinen T, Mikola H, Kärki T and Tarvainen MP. 2011. Physiological measurement. 32: 649-660 A1 Journal article (refereed), original research
Hypoglycemia detection based on cardiac repolarization features
Lipponen JA , Kemppainen J, Karjalainen PA, Laitinen T, Mikola H, Kärki T and Tarvainen MP. Teoksessa: IEEE(toim.) , 2011. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. s. 4697-4700. IEEE A4 Conference proceedings
Measurements of Skin Temperature Responses to Cold Exposure of Foot and Face in Healthy Individuals: Variability and Influencing Factors.
Zaproudina N, Lipponen JA, Eskelinen P, Tarvainen MP, Karjalainen PA, Närhi M. 2011. Clinical physiology and functional imaging. 31: 307-314 A1 Journal article (refereed), original research
Measurements of skin temperature responses to cold exposure of foot and face in healthy individuals: Variability and influencing factors
Zaproudina N, Lipponen JA, EskelinenP, Tarvainen MP, KarjalainenPA, Närhi M. 2011. Clinical physiology and functional imaging. 31: 307-314 A1 Journal article (refereed), original research
Vectorcardiographic Changes During Exercise Test - Correlates to Lactate and Anaerobic Threshold?
Lipponen JA, Gladwell VF, Kinnunen H, Karjalainen PA, Tarvainen MP. Teoksessa: Computing in Cardiology(toim.) , 2011. Computing in Cardiology 2011, Volume 38. s. 765-768. IEEE A4 Conference proceedings
A Principal Component Regression Approach for Estimation of Ventricular Repolarization Characteristics
Jukka Antero Lipponen, Mika P. Tarvainen, Tomi Laitinen, Tiina Lyyra-Laitinen ja Pasi A. Karjalainen. 2010. IEEE transactions on biomedical engineering. 57: 1062-1069 A1 Journal article (refereed), original research
Analysis of Heart Rate Variability Dynamics During Propofol and Dexmedetomidine Anesthesia
Tarvainen MP, Georgiadis S, Lipponen JA, Laitio T, Karjalainen PA, Scheinin H & Kaskinoro K. Teoksessa: Armentano R, Hudson D, Monzon J & Patton J(toim.) , 2010. Proceedings of the 32nd Annual International Conference of the IEEE EMBS. s. 1634-1637. A4 Conference proceedings
The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice
Huusko J, Merentie M, Dijkstra MH, Ryhänen M-M, Karvinen H, Rissanen TT, Vanwildemeersch M, Hedman M, Lipponen J, Heinonen SE et al. 2010. Cardiovascular research. 86: 122-130 A1 Journal article (refereed), original research
Analysis of heart rate variability dynamics during propofol anesthesia
Tarvainen MP, Georgiadis S, Lipponen JA, Laitio T, Kaskinoro K, Schein H, Karjalainen PA. Teoksessa: Dössler O, Schlegel WC(toim.) , 2009. World Congress on Medical Physics and Biomedical Engineering. s. 868-871. Springer A4 Conference proceedings
Baseline removal from near infrared spectroscopy measurements for lactate concentration estimation
Lipponen JA, Blomberg von der Geest K, Tarvainen MP, Leinonen A, Lahtinen M, Karjalainen PA. Teoksessa: Dössel O, Schlegel WC(toim.) , 2009. World Congress on Medical Physics and Biomedical Engineering. s. 2042-2045. Springer A4 Conference proceedings
Estimation of T-wave morphology using Gaussian functions
Lipponen JA, Tarvainen MP, Lyyra-Laitinen T, Laitinen T, Karjalainen PA. Teoksessa: Dössel O, Schlegel WC(toim.) , 2009. World Congress on Medical Physics and Biomedical Engineering. s. 895-897. Springer A4 Conference proceedings
Kubios HRV
Tarvainen MP, Niskanen J-P, Ranta-aho PO, Karjalainen PA, Lipponen J. 2009. I2 ICT software
Time-Varying spectrum estimation of heart rate variability signals with Kalman smoother algorithm
Tarvainen MP, Georgiadis S, Lipponen JA, Hakkarainen M, Karjalainen PA. Teoksessa: (toim.) , 2009. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society. s. 1-4. A4 Conference proceedings
Kubios HRV- a software for advanced heart rate variability analysis
Tarvainen MP, Niskanen JP, Lipponen JA, Ranta-aho PO, Karjalainen PA. Teoksessa: vander Sloten J, Verdonck P, Nyssen M, Haueisen J(toim.) , 2008. IFMBE Proceedings ECIFMBE 2008. 4th European Conference of the International Federation for Medical and Biological Engineering. s. 1022-1025. Springer-Verlag A4 Conference proceedings

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Jukka Lipponen

Autonomic responses to tooth clenching and handgrip test

Continuous 24-h Photoplethysmogram Monitoring Enables Detection of Atrial Fibrillation

Continuous mHealth Patch Monitoring for the Algorithm-Based Detection of Atrial Fibrillation: Feasibility and Diagnostic Accuracy Study

Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history

Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals

Necklace-embedded electrocardiogram for the detection and diagnosis of atrial fibrillation

Wrist Band Photoplethysmography Autocorrelation Analysis Enables Detection of Atrial Fibrillation Without Pulse Detection

A robust algorithm for heart rate variability time series artefact correction using novel beat classification

Effectiveness of the Chest Strap Electrocardiogram to Detect Atrial Fibrillation

Recovery from sauna bathing favorably modulates cardiac autonomic nervous system

Terveelliset välipalat parantavat ikäihmisten ravitsemustilaa

Wrist band photoplethysmography in detection of individual pulses in atrial fibrillation and algorithm-based detection of atrial fibrillation

Autonomic responses to tooth clenching in migraineurs - augmented trigeminocardiac reflex?

Electrical and mechanical dyssynchrony in patients with right bundle branch block

Global electrical heterogeneity as a predictor of cardiovascular mortality in men and women

Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls

Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs

Analysis and Preprocessing of HRV-Kubios HRV Software

Heart Rate Variability During Cardiorespiratory Exercise Test in Type 1 Diabetes

Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice

Beat to beat estimation of cosRT angle and cosRT RR hysteresis from exercise ECG measurement

Cardiac autonomic dysfunction in type 2 diabetes - effect of hyperglycemia and disease duration

Estimation Methods for Cardiovascular Signal Analysis

Heart rate variability evaluation of Emfit sleep mattress breathing categories in NREM sleep

Principal component model for maternal ECG extraction in fetal QRS detection

Acral coldness in migraineurs

Advanced Maternal ECG Removal and Noise Reduction for Application of Fetal QRS Detection

Asynchronicity of facial blood perfusion in migraine

Causal estimation of neural and overall baroreflex sensitivity in relation to carotid artery stiffness

Complexity of heart rate variability in type 2 diabetes - effect of hyperglycemia

Dynamic Modeling of Respiratory Sinus Arrhythmia Component from HRV with Multivariate Kalman Smoother

Kubios HRV - Heart rate variability analysis software

Nitroglycerin-induced changes in facial skin temperature: 'cold nose' as a predictor of headache?

The correlation of vectorcardiographic changes to blood lactate concentration during an exercise test

Effect of hyperglycemia on cardiac autonomic function in type 2 diabetes

Estimation of arterial baroreflex sensitivity in relation to carotid artery stiffness

Heart rate variability dynamics during low-dose propofol and dexmedetomidine anesthesia

Cholesterol metabolism, endothelial dysfunction, and carotid artery stiffness in type 1 diabetes

Continuous analysis of repolarization characteristics during insulin induced hypoglycemia

Dynamic estimation of cardiac repolarization characteristics during hypoglycemia in healthy and diabetic subjects.

Hypoglycemia detection based on cardiac repolarization features

Measurements of Skin Temperature Responses to Cold Exposure of Foot and Face in Healthy Individuals: Variability and Influencing Factors.

Measurements of skin temperature responses to cold exposure of foot and face in healthy individuals: Variability and influencing factors

Vectorcardiographic Changes During Exercise Test - Correlates to Lactate and Anaerobic Threshold?

A Principal Component Regression Approach for Estimation of Ventricular Repolarization Characteristics

Analysis of Heart Rate Variability Dynamics During Propofol and Dexmedetomidine Anesthesia

The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice

Analysis of heart rate variability dynamics during propofol anesthesia

Baseline removal from near infrared spectroscopy measurements for lactate concentration estimation

Estimation of T-wave morphology using Gaussian functions

Kubios HRV

Time-Varying spectrum estimation of heart rate variability signals with Kalman smoother algorithm

Kubios HRV- a software for advanced heart rate variability analysis