Krista Laine

Design of an educational escape game in a laboratory environment: A novel method to practise drug compounding competence for a hospital pharmacy

Toropainen, Tarja; Tahvanainen, Ville; Laine, Krista, 2025, Pharmacy education, 25, 1, 493-501. A1 Journal article (refereed), original research

Farmaseuttisen kemian perusteet

Rautio, Jarkko; Laine, Krista; Jarho, Pekka; Wallén, Erik; Poso, Antti; Saarinen, Jukka; Auriola, Seppo; Vuorensola, Katariina; Wikberg, Tom; Lindake, Björn, 2025, Farmasian opiskelijayhdistys Fortis ry. D5 Textbook, professional manual or guide

Large-group simulation as a remote learning method in interprofessional health care education - a mixed methods study

Pajari, Juha; Saaranen, Terhi; Laine, Krista; Silén-Lipponen, Marja, 2025, Nurse education today, 150, 106716. A1 Journal article (refereed), original research

Vahvuutta monialaiseen osaamiseen suursimulaatiolla

Pajari, Juha; Silén-Lipponen, Marja; Laine, Krista; Saaranen, Terhi, 2025, Pro terveys, 52, 1, 8-9. D1 Article in a trade journal

Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM, 2018, International journal of pharmaceutics, 544, 1, 91-99. A1 Journal article (refereed), original research

Aihiolääketeknologia lääkekehityksessä

Rautio Jarkko, Huttunen Kristiina, Gynther Mikko, Laine Krista, Leppänen Jukka, Kärkkäinen Jussi, Malmioja Kalle, 2014, Dosis, 30, 3, 209. B1 Non-refereed journal articles

Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1)

Ylikangas Henna, Malmioja Kalle, Peura Lauri, Gynther Mikko, Nwachukwu Emmanuel O, Leppänen Jukka, Laine Krista, Rautio Jarkko, Lahtela-Kakkonen Maija, Huttunen Kristiina M, Poso Antti, 2014, Chemmedchem, 9, 2699-2707. A1 Journal article (refereed), original research

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko, 2013, European journal of pharmaceutical sciences, 49, 624-628. A1 Journal article (refereed), original research

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine

Peura Lauri, Malmioja Kalle, Huttunen Kristiina, Leppänen Jukka, Hämäläinen Miia, Forsberg Markus M, Gynther Mikko, Rautio Jarkko, Laine Krista, 2013, Pharmaceutical research, 30, 2523-2537. A1 Journal article (refereed), original research

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

Ylikangas Henna, Peura Lauri, Malmioja Kalle, Leppänen Jukka, Laine Krista, Poso Antti, Lahtela-Kakkonen Maija, Rautio Jarkko, 2012, European journal of pharmaceutical sciences, 2013:48, 523-531. A1 Journal article (refereed), original research

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery

Peura Lauri, Malmioja Kalle, Laine Krista, Leppänen Jukka, Gynther Mikko, Isotalo Antti, Rautio Jarkko, 2011, Molecular pharmaceutics, 8, 5, 1857-1866. A1 Journal article (refereed), original research

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor

Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M, 2010, Bioorganic and medicinal chemistry letters, 20, 2614 - 2616. A1 Journal article (refereed), original research

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats

Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J, 2009, Journal of medicinal chemistry, 52, 3348-3353. A1 Journal article (refereed), original research

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J, 2009, Journal of medicinal chemistry, 52, 4142-4148. A1 Journal article (refereed), original research

Enhanced brain drug delivery and targeting

Rautio J, Laine K, Gynther M, 2008, PHARMACEUTICAL TECHNOLOGY EUROPE, 20, 4, 27-33. D1 Article in a trade journal

Large neutral amino acid transporter enables brain drug delivery via prodrugs

Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J, 2008, Journal of medicinal chemistry, 51, 932-936. A1 Journal article (refereed), original research

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs

Niemi R, Huuskonen J, Laine K, Järvinen T, 2005, International journal of pharmaceutics, 295, 121-127. A1 Journal article (refereed), original research

Elimistön kannabinoidijärjestelmään vaikuttavat yhdisteet alentavat kaniinien silmänpainetta

Laine K, 2004, Dosis, 20, 4, 319-324. A1 Journal article (refereed), original research

Intraocular Pressure Lowering Activities of Endogenous Cannabinoids, and Their Uptake and Enzyme Hydrolysis Inhibitors in Normotensive Rabbits

Laine K, 2004, Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. G5 Doctoral dissertation (article)

Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide

Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Järvinen T, 2003, European journal of pharmaceutical sciences, 19, 37-43. A1 Journal article (refereed), original research

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether

Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T, 2003, Journal of medicinal chemistry, 46, 5083-5086. A1 Journal article (refereed), original research

Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

Laine K, Järvinen K, Järvinen T, 2003, Life sciences, 72, 837-842. A1 Journal article (refereed), original research

Cannabinoids in the treatment of glaucoma

Järvinen T, Pate DW, Laine K, 2002, Pharmacology and therapeutics, 95, 203-220. A1 Journal article (refereed), original research

Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid

Laine K, Järvinen K, Mechoulam R, Breuer A, Järvinen T, 2002, Investigative ophthalmology and visual science, 43, 10, 3216-3222. A1 Journal article (refereed), original research

Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides

Laine K, Järvinen K, Pate DW, Urtti A, Järvinen T, 2002, Investigative ophthalmology and visual science, 43, 2, 393-397. A1 Journal article (refereed), original research

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent G-protein activation in rat cerebellar membranes

Savinainen JR, Järvinen T, Laine K, Laitinen JT, 2001, British journal of pharmacology, 134, 664-672. A1 Journal article (refereed), original research

Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits

Laine K, Järvinen T, Savinainen J, Laitinen JT, Pate DW, Järvinen K, 2001, Pharmaceutical research, 18, 4, 494-499. A1 Journal article (refereed), original research

Kannabinoidit - tulevaisuuden lääkeaineita?

Laine K, Järvinen K, Järvinen T, 2001, Dosis, 17, 1, 39-50. A2 Review article, Literature review, Systematic review

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T, 2000, European journal of pharmaceutical sciences, 11, 157-163. A1 Journal article (refereed), original research

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T, 2000, Journal of medicinal chemistry, 43, 8, 1489-1494. A1 Journal article (refereed), original research

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Design of an educational escape game in a laboratory environment: A novel method to practise drug compounding competence for a hospital pharmacy

Farmaseuttisen kemian perusteet

Large-group simulation as a remote learning method in interprofessional health care education - a mixed methods study

Vahvuutta monialaiseen osaamiseen suursimulaatiolla

Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Aihiolääketeknologia lääkekehityksessä

Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1)

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine

LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?

Amino acids as promoieties in prodrug design and development

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Enhanced brain drug delivery and targeting

Large neutral amino acid transporter enables brain drug delivery via prodrugs

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs

Elimistön kannabinoidijärjestelmään vaikuttavat yhdisteet alentavat kaniinien silmänpainetta

Intraocular Pressure Lowering Activities of Endogenous Cannabinoids, and Their Uptake and Enzyme Hydrolysis Inhibitors in Normotensive Rabbits

Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether

Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

Cannabinoids in the treatment of glaucoma

Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid

Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent G-protein activation in rat cerebellar membranes

Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits

Kannabinoidit - tulevaisuuden lääkeaineita?

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery