Krista Laine

Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. 2018. International journal of pharmaceutics. 544: 91-99 A1 Journal article (refereed), original research

Aihiolääketeknologia lääkekehityksessä

Rautio Jarkko, Huttunen Kristiina, Gynther Mikko, Laine Krista, Leppänen Jukka, Kärkkäinen Jussi, Malmioja Kalle. 2014. Dosis. 30: 209 B1 Non-refereed journal articles

Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1)

Ylikangas Henna, Malmioja Kalle, Peura Lauri, Gynther Mikko, Nwachukwu Emmanuel O, Leppänen Jukka, Laine Krista, Rautio Jarkko, Lahtela-Kakkonen Maija, Huttunen Kristiina M, Poso Antti. 2014. Chemmedchem. 9: 2699-2707 A1 Journal article (refereed), original research

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko. 2013. European journal of pharmaceutical sciences. 49: 624-628 A1 Journal article (refereed), original research

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine

Peura Lauri, Malmioja Kalle, Huttunen Kristiina, Leppänen Jukka, Hämäläinen Miia, Forsberg Markus M, Gynther Mikko, Rautio Jarkko, Laine Krista. 2013. Pharmaceutical research. 30: 2523-2537 A1 Journal article (refereed), original research

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

Ylikangas Henna, Peura Lauri, Malmioja Kalle, Leppänen Jukka, Laine Krista, Poso Antti, Lahtela-Kakkonen Maija, Rautio Jarkko. 2012. European journal of pharmaceutical sciences. 2013:48: 523-531 A1 Journal article (refereed), original research

Enzyme-activated prodrug strategies for site-selective drug delivery

Laine Krista, Huttunen Kristiina. Teoksessa: Rautio Jarkko(toim.) , 2011. Prodrugs and Targeted Delivery. s. 231-252. Wiley-VCH Verlag A3 Book section, Chapters in research books

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery

Peura Lauri, Malmioja Kalle, Laine Krista, Leppänen Jukka, Gynther Mikko, Isotalo Antti, Rautio Jarkko. 2011. Molecular pharmaceutics. 8: 1857-1866 A1 Journal article (refereed), original research

New Prodrug Design Ideas for Transporter-Mediated CNS Drug Delivery

Kalle Malmioja, Lauri Peura, Krista Laine, Jukka Leppänen, Mikko Gynther, Jarkko Rautio. 2011.

New Prodrug Desing Ideas for Large Amino Acid Transporter 1 -Mediated Drug Brain Delivery

Peura L, Malmioja K, Laine K, Leppänen J, Gynther M & Rautio J. 2011.

Brain uptake of ketoprofen-lysine prodrug in rats

Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J & Rautio J. 2010. International journal of pharmaceutics. 399: 121-128 A1 Journal article (refereed), original research

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor

Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M. 2010. Bioorganic and medicinal chemistry letters. 20: 2614 - 2616 A1 Journal article (refereed), original research

Enzyme-activated prodrug strategies for targeted drug action

Rautio Jarkko, Laine Krista, Fang Lanyan, Han Bing, Huttunen Kristiina, Sun Duxin. Teoksessa: Ram I. Mahato and Ajit S. Narang(toim.) , 2010. Targeted Delivery of Small and Macromolecular Drugs. s. 311-348. CRC Press, Taylor& Francis Group A3 Book section, Chapters in research books

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats

Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J. 2009. Journal of medicinal chemistry. 52: 3348-3353 A1 Journal article (refereed), original research

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. 2009. Journal of medicinal chemistry. 52: 4142-4148 A1 Journal article (refereed), original research

Enhanced brain drug delivery and targeting

Rautio J, Laine K, Gynther M. 2008. PHARMACEUTICAL TECHNOLOGY EUROPE. 20: 27-33 D1 Article in a trade journal

Large neutral amino acid transporter enables brain drug delivery via prodrugs

Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J. 2008. Journal of medicinal chemistry. 51: 932-936 A1 Journal article (refereed), original research

Prodrug approaches for CNS delivery

Rautio Jarkko, Laine Krista, Gynther Mikko, Savolainen Jouko. 2008. AAPS journal. 10: 92-102 A2 Review article, Literature review, Systematic review

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs

Niemi R, Huuskonen J, Laine K, Järvinen T. 2005. International journal of pharmaceutics. 295: 121-127 A1 Journal article (refereed), original research

Elimistön kannabinoidijärjestelmään vaikuttavat yhdisteet alentavat kaniinien silmänpainetta

Laine K. 2004. Dosis. 20: 319-324 A1 Journal article (refereed), original research

Intraocular Pressure Lowering Activities of Endogenous Cannabinoids, and Their Uptake and Enzyme Hydrolysis Inhibitors in Normotensive Rabbits

Laine K. 2004. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet G5 Doctoral dissertation (article)

Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide

Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Järvinen T. 2003. European journal of pharmaceutical sciences. 19: 37-43 A1 Journal article (refereed), original research

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether

Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T. 2003. Journal of medicinal chemistry. 46: 5083-5086 A1 Journal article (refereed), original research

Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

Laine K, Järvinen K, Järvinen T. 2003. Life sciences. 72: 837-842 A1 Journal article (refereed), original research

Cannabinoids in the treatment of glaucoma

Järvinen T, Pate DW, Laine K. 2002. Pharmacology and therapeutics. 95: 203-220 A1 Journal article (refereed), original research

Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid

Laine K, Järvinen K, Mechoulam R, Breuer A, Järvinen T. 2002. Investigative ophthalmology and visual science. 43: 3216-3222 A1 Journal article (refereed), original research

Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides

Laine K, Järvinen K, Pate DW, Urtti A, Järvinen T. 2002. Investigative ophthalmology and visual science. 43: 393-397 A1 Journal article (refereed), original research

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent G-protein activation in rat cerebellar membranes

Savinainen JR, Järvinen T, Laine K, Laitinen JT. 2001. British journal of pharmacology. 134: 664-672 A1 Journal article (refereed), original research

Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits

Laine K, Järvinen T, Savinainen J, Laitinen JT, Pate DW, Järvinen K. 2001. Pharmaceutical research. 18: 494-499 A1 Journal article (refereed), original research

Kannabinoidit - tulevaisuuden lääkeaineita?

Laine K, Järvinen K, Järvinen T. 2001. Dosis. 17: 39-50 A2 Review article, Literature review, Systematic review

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. European journal of pharmaceutical sciences. 11: 157-163 A1 Journal article (refereed), original research

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Journal of medicinal chemistry. 43: 1489-1494 A1 Journal article (refereed), original research

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Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Aihiolääketeknologia lääkekehityksessä

Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1)

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine

LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?

Amino acids as promoieties in prodrug design and development

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

Enzyme-activated prodrug strategies for site-selective drug delivery

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery

New Prodrug Design Ideas for Transporter-Mediated CNS Drug Delivery

New Prodrug Desing Ideas for Large Amino Acid Transporter 1 -Mediated Drug Brain Delivery

Brain uptake of ketoprofen-lysine prodrug in rats

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor

Enzyme-activated prodrug strategies for targeted drug action

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Enhanced brain drug delivery and targeting

Large neutral amino acid transporter enables brain drug delivery via prodrugs

Prodrug approaches for CNS delivery

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs

Elimistön kannabinoidijärjestelmään vaikuttavat yhdisteet alentavat kaniinien silmänpainetta

Intraocular Pressure Lowering Activities of Endogenous Cannabinoids, and Their Uptake and Enzyme Hydrolysis Inhibitors in Normotensive Rabbits

Anandamide prodrugs: 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether

Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

Cannabinoids in the treatment of glaucoma

Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid

Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent G-protein activation in rat cerebellar membranes

Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits

Kannabinoidit - tulevaisuuden lääkeaineita?

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery