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Leea Keski-Nisula

Leea Keski-Nisula

Professor

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

[email protected]

Information Publications

Research groups

Kuopio Birth Cohort (KuBiCo) 01.07.2012 -
Nutritional epidemiology research group 01.01.1996 -

Publications

100/100 items

Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Masvosva, Wadzanai; Voutilainen, Taija; Lehtonen, Marko; Haikonen, Retu; Auriola, Seppo; Keski‐Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli. 2025. Basic and clinical pharmacology and toxicology. 136: 1-11 A1 Journal article (refereed), original research
Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study
Cheng, Feon W.; Bauer, Ella; Ford, Nikki A.; Backman, Katri; Voutilainen, Raimo; Pasanen, Markku; Keski-Nisula, Leea; Hantunen, Sari. 2025. Pediatric research. [Published: 07 March 2025]: 1-7 A1 Journal article (refereed), original research
Earlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns
Hurme, Veera; Honkanen, Reetta; Backman, Katri; Karvonen, Anne M; Kirjavainen, Pirkka; Keski-Nisula, Leea. 2025. Journal of reproductive immunology. 168: A1 Journal article (refereed), original research
Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy
Itkonen, Anna; Kärkkäinen, Olli; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana. 2025. Metabolomics. 21: . 123 A1 Journal article (refereed), original research
Maternal exercise during pregnancy is associated with reduced risk of asthma in the child: A prospective birth cohort study
Musakka, Emma-Reetta; Ylilauri, Maija Paula Tuulia; Jalanka, Jonna; Karvonen, Anne Maarit; Täubel, Martin; Hantunen, Sari; Lehto, Soili Marianne; Pekkanen, Juha; Backman, Katri; Keski-Nisula, Leea; Kirjavainen, Pirkka Viljami. 2025. Med. 6: A1 Journal article (refereed), original research
Ravintolisien käyttö raskauden aikana Pohjois-Savossa
Kortelainen, Hanna; Rysä, Jaana; Hantunen, Sari; Keski-Nisula, Leea; Sahlman, Heidi. 2025. Dosis. 41: 56-71 A1 Journal article (refereed), original research
Trajectories of Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Perinatal Outcomes: A Longitudinal Register Study
Bernhardsen, Guro Pauck; Pesonen, Maiju; Keski‐Nisula, Leea; Nordeng, Hedvig; Lehto, Soili M. 2025. Bjog: an international journal of obstetrics and gynaecology. [First published: 20 August 2025]: . A1 Journal article (refereed), original research
Associations of gestational anxiety and depression with neonatal hair steroid levels
Chortatos, Arthur; Vittersø, Axel Davies; Uusitalo, Lauri; Lehtonen, Marko; Huotari, Johanna; Auriola, Seppo; Voutilainen, Raimo; Backman, Katri; Keski-Nisula, Leea; Lehto, Soili M. 2024. Psychoneuroendocrinology. 2025; 172: A1 Journal article (refereed), original research
Delayed umbilical cord clamping in elective and nonelective term Cesarean delivery
Lummevaara, Liina; Ordén, Maija-Riitta; Mykkänen, Anu; Keski-Nisula, Leea. 2024. Journal of gynecology obstetrics and human reproduction. 53: A1 Journal article (refereed), original research
Fear of Childbirth Impairs Breastfeeding Success Independent of Mode of Birth
Vasanen, Maija; Kukkonen, Anni; Backman, Katri; Hantunen, Sari; Keski-Nisula, Leea. 2024. Breastfeeding medicine. 19: 932–940 A1 Journal article (refereed), original research
Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort
Kukkonen, Anni; Hantunen, Sari; Voutilainen, Ari; Ruusunen, Anu; Backman, Katri; Kirjavainen, Pirkka V.; Ylilauri, Maija; Voutilainen, Raimo; Pasanen, Markku; Keski-Nisula, Leea. 2024. Archives of gynecology and obstetrics. 310: 359-368 A1 Journal article (refereed), original research
Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort
Kukkonen, Anni; Hantunen, Sari; Voutilainen, Ari; Ruusunen, Anu; Uusitalo, Lauri; Backman, Katri; Voutilainen, Raimo; Pasanen, Markku; Kirjavainen, Pirkka V; Keski-Nisula, Leea. 2024. Primary care diabetes. 18: 362-367 A1 Journal article (refereed), original research
Maternal dietary indexes are not linked to early childhood wheezing or atopic eczema
Sivula, Elina; Puharinen, Heidi; Hantunen, Sari; Keski‐Nisula, Leea; Backman, Katri. 2024. Pediatric allergy and immunology. 35: A1 Journal article (refereed), original research
Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood
Chortatos, Arthur; Pesonen, Maiju; Thomas, Owen; Toffol, Elena; Airaksinen, Ville; Musakka, Emma; Täubel, Martin; Kirjavainen, Pirkka; Backman, Katri; Pekkanen, Juha; Keski-Nisula, Leea; Lehto, Soili M. 2024. Development and psychopathology. [Published online: 16 October 2024]: 1-12 A1 Journal article (refereed), original research
Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies
Voutilainen, Taija; Keski-Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli. 2024. Basic and clinical pharmacology and toxicology. 134: 543-555 A1 Journal article (refereed), original research
The association between gestational diabetes and fear of childbirth: a longitudinal register study
Savard, Josephine; Pauck Bernhardsen, Guro; Mykkänen, Anu; Keski-Nisula, Leea; Lehto, Soili Marianne. 2024. Bmc pregnancy and childbirth. 24: . 814 A1 Journal article (refereed), original research
Umbilical arterial lactate levels after normal vaginal and elective cesarean delivery: The role of a longer active second stage most significant in high levels after vaginal delivery
Mönkkönen, Arttu; Rajala, Katri; Backman, Heli; Keski‐Nisula, Leea. 2024. Journal of obstetrics and gynaecology research. 50: 557-565 A1 Journal article (refereed), original research
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Koskivuori, Johanna; Voutilainen, Raimo; Storvik, Markus; Hakkinen, Merja R.; Uusitalo, Lauri; Keski-Nisula, Leea; Backman, Katri; Auriola, Seppo; Lehtonen, Marko. 2023. Journal of steroid biochemistry and molecular biology. 232: A1 Journal article (refereed), original research
High estradiol levels during a long agonist IVF protocol are associated with decreased food intake, higher leptin concentrations, and lower levels of high-sensitivity C-reactive protein
Leppänen, Jonna; Nuotio, Petrus; Randell, Kaisa; Romppanen, Jarkko; Keski-Nisula, Leea; Laitinen, Tomi; Pihlajamäki, Jussi; Schwab, Ursula; Heinonen, Seppo. 2023. Archives of gynecology and obstetrics. 308: 883-891 A1 Journal article (refereed), original research
Quetiapine and other antipsychotic medications during pregnancy: a 15-year follow-up of a university hospital birth register
Kananen, Anniina; Bernhardsen, Guro Pauck; Lehto, Soili Marianne; Huuskonen, Pasi; Kokki, Hannu; Keski-Nisula, Leea. 2023. Nordic journal of psychiatry. 77: 651-660 A1 Journal article (refereed), original research
Vulvovaginal yeast infections, gestational diabetes and pregnancy outcome
Blomberg, Leeni; Backman, Katri; Kirjavainen, Pirkka V; Karvonen, Anne M; Harju, Maijakaisa; Keski-Nisula, Leea. 2023. Bmc pregnancy and childbirth. 23: . 70 A1 Journal article (refereed), original research
Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy
Sahlman, H; Itkonen, A; Lehtonen, M; Keski-Nisula, L; Rysä, J. 2022. Placenta. 129: 30-35 A1 Journal article (refereed), original research
Imukuppiavusteinen synnytys KYS:ssa
Älli, Selina; Alanne, Leena; Keski-Nisula, Leea. 2022. Kätilölehti. 127: 16-18 D1 Article in a trade journal
Longitudinal Analyses of Diet Quality and Maternal Depressive Symptoms During Pregnancy: The Kuopio Birth Cohort Study
Airaksinen, Ville; Ruohomäki, Aleksi; Hantunen, Sari; Keski-Nisula, Leea; Luojus, Maria Katariina; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Heinonen, Seppo; Pasanen, Markku; Lehto, Soili Marianne. 2022. Journal of the academy of nutrition and dietetics. 2023; 123: 77-86.e4 A1 Journal article (refereed), original research
Perinatal factors and high-sensitive C-reactive protein levels during adolescence
Marila, Anna; Karvonen, Anne M; Pekkanen, Juha; Keski-Nisula, Leea. 2022. European journal of inflammation. 20: 1-9 A1 Journal article (refereed), original research
Self‐reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies
Voutilainen, Taija; Rysä, Jaana; Keski‐Nisula, Leea; Kärkkäinen, Olli. 2022. Alcoholism-clinical and experimental research. 46: 797-808 A1 Journal article (refereed), original research
Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol
Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Romppanen, Jarkko; Keski-Nisula, Leea; Heinonen, Seppo; Laitinen, Tomi. 2021. Journal of reproductive immunology. 148: 103434 A1 Journal article (refereed), original research
Farm environment during pregnancy and childhood and polysensitization at the age of 31 - Prospective birth cohort study in Finland
Karvonen, AM; Lampi, J; Keski-Nisula, L; Auvinen, J; Toppila, Salmi, S; Järvelin, MR; Pekkanen, J. 2021. Journal of investigational allergology and clinical immunology. 31: 44-51 A1 Journal article (refereed), original research
Fetal lactate levels align with the stage of labour
Rajala, K.; Mönkkönen, A.; Saarelainen, H.; Keski-Nisula, L.. 2021. European journal of obstetrics and gynecology and reproductive biology. 261: 139-143 A1 Journal article (refereed), original research
Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence?
von Hellens, Hetti; Keski-Nisula, Leea; Sahlman, Heidi. 2021. Bmc pregnancy and childbirth. 21: 24 A1 Journal article (refereed), original research
Robotic-assisted laparoscopy is a feasible method for resection of deep infiltrating endometriosis, especially in the rectosigmoid area
Hiltunen, Janika; Eloranta, Marja-Liisa; Lindgren, Auni; Keski-Nisula, Leea; Anttila, Maarit; Sallinen, Hanna. 2021. Journal of international medical research. 49: 1-12 A1 Journal article (refereed), original research
The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study
Ruohomäki, Aleksi; Toffol, Elena; Airaksinen, Ville; Backman, Katri; Voutilainen, Raimo; Hantunen, Sari; Tuomainen, Tomi-Pekka; Lampi, Jussi; Kokki, Hannu; Luoma, Ilona; Kumpulainen, Kirsti; Heinonen, Seppo; Keski-Nisula, Leea; Pekkanen, Juha; Pasanen, Markku; Lehto, Soili M.. 2021. Journal of psychiatric research. 136: 388-397 A1 Journal article (refereed), original research
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. European journal of nutrition. 2021; 60: 193-201 A1 Journal article (refereed), original research
High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
Sopo, Minna; Sallinen, Hanna; Hämäläinen, Kirsi; Kivelä, Annukka; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Anttila, Maarit. 2020. PLoS ONE. 15: e0241484 A1 Journal article (refereed), original research
Hypothyroidism and the increased risk of preeclampsia - interpretative factors?
Lintula, Aino; Keski-Nisula, Leea; Sahlman, Heidi. 2020. Hypertension in pregnancy. 39: 411-417 A1 Journal article (refereed), original research
Lapsettomuushoidon ensikäynnistä kaksi vuotta. Yli puolelle hoidetuista lapsi
Kerttula, Salla; Keski-Nisula, Leea; Kuivasaari-Pirinen, Paula. 2020. Lääkärilehti. 75: 1441-1446 A1 Journal article (refereed), original research
Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors
Sopo, Minna; Anttila, Maarit; Muukkonen, Oona-Tuuli; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Sallinen, Hanna. 2020. Anticancer research. 40: 6923-6931 A1 Journal article (refereed), original research
The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol
Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Keski-Nisula, Leea; Laitinen, Tomi; Heinonen, Seppo. 2020. Reproductive biology and endocrinology. 18: 44 A1 Journal article (refereed), original research
Bakteeri-infektiot
Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea. Teoksessa: Tapanainen, Juha; Heikinheimo, Oskari; Mäkikallio, Kaarin(toim.) , 2019. Naistentaudit ja synnytykset. s. -. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
Sopo, M; Anttila, M; Hämäläinen, K; Kivelä, A; Ylä-Herttuala, S; Kosma, VM; Keski-Nisula, L; Sallinen, H. 2019. Bmc cancer. 19: 584 A1 Journal article (refereed), original research
Kunnankätilö Makkosen hoitamat kotisynnytykset Pohjois-Savossa vuonna 1958
Soininen, Jenni; Keski-Nisula, Leea. 2019. Duodecim. 135: 2437-2345 A1 Journal article (refereed), original research
Maternal use of drugs and preeclampsia
Sahlman, H; Koponen, M; El-Nezami, H; Vahakangas, K; Keski-Nisula, L. 2019. British journal of clinical pharmacology. 85: 2848-2855 A1 Journal article (refereed), original research
Raskaudenaikaiset infektiot
Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea. Teoksessa: Tapanainen, Juha; Heikinheimo, Oskari; Mäkikallio, Kaarin(toim.) , 2019. Naistentaudit ja synnytykset. s. -. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
The dynamic course of peripartum depression across pregnancy and childbirth
Dekel, S; Ein-Dor, T; Ruohomäki, A; Lampi, J; Voutilainen, S; Tuomainen, TP; Heinonen, S; Kumpulainen, K; Pekkanen, J; Keski-Nisula, L; Pasanen, M; Lehto, SM. 2019. Journal of psychiatric research. 113: 72-78 A1 Journal article (refereed), original research
Virusinfektiot
Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea. Teoksessa: Tapanainen, Juha; Heikinheimo, Oskari; Mäkikallio, Kaarin(toim.) , 2019. Naistentaudit ja synnytykset. s. -. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Zoonoosit
Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea. Teoksessa: Tapanainen, Juha; Heikinheimo, Oskari; Mäkikallio, Kaarin(toim.) , 2019. Naistentaudit ja synnytykset. s. -. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women
Vuokko, Aki; Karvala, Kirsi; Lampi, Jussi; Keski-Nisula, Leea; Pasanen, Markku; Voutilainen, Raimo; Pekkanen, Juha; Sainio, Markku. 2018. International journal of environmental research and public health. 15: 293 A1 Journal article (refereed), original research
Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child
Huuskonen, P; Keski-Nisula, L; Heinonen, S; Voutilainen, S; Tuomainen, TP; Pekkanen, J; Lampi, J; Lehto, SM; Haaparanta, H; Elomaa, AP; Voutilainen, R; Backman, K; Kokki, H; Kumpulainen, K; Paananen, J; Vähäkangas, K; Pasanen, M. 2018. Bmc pregnancy and childbirth. 18: 381 A1 Journal article (refereed), original research
Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring
Harju, Maijakaisa; Pekkanen, Juha; Heinonen, Seppo; Keski-Nisula, Leea. 2018. Journal of obstetrics and gynaecology research. 44: 614-622 A1 Journal article (refereed), original research
The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study
Ruohomäki, Aleksi; Toffol, Elena; Upadhyaya, Subina; Keski-Nisula, Leea; Pekkanen, Juha; Lampi, Jussi; Voutilainen, Sari; Tuomainen, Tomi-Pekka; Heinonen, Seppo; Kumpulainen, Kirsti; Pasanen, Markku; Lehto, Soili M. 2018. Journal of affective disorders. 241: 263-268 A1 Journal article (refereed), original research
Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: A population-based study
Sokka Arja, Olsen Päivi, Kirjavainen Jarkko, Harju Maijakaisa, Keski-Nisula Leea, Räisänen Sari, Heinonen Seppo, Kälviäinen Reetta. 2017. Epilepsia open. 2: 76-83 A1 Journal article (refereed), original research
The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life
Martikainen M-V, Keski-Nisula L, Jakupovic H, Karvonen AM, Pekkanen J, Hirvonen M-R, Roponen M. 2017. American journal of reproductive immunology. 77: - A1 Journal article (refereed), original research
Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy
Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin J-C, Kaulek V, Loss GJ, Lauener R, Hirvonen M-R, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J, the PASTURE study group. 2016. Pediatric allergy and immunology. 2017; 28: 53-59 A1 Journal article (refereed), original research
Parental smoking and cessation during pregnancy and the risk of childhood asthma
Harju Maijakaisa, Keski-Nisula Leea, Georgiadis Leena, Heinonen Seppo. 2016. Bmc public health. 16: 1-7 A1 Journal article (refereed), original research
The human placental proteome is affected by maternal smoking
Huuskonen Pasi, Amezaga Maria R, Bellingham Michelle, Jones Lucy H, Storvik Markus, Häkkinen Merja, Keski-Nisula Leea, Heinonen Seppo, O'Shaughnessy Peter J, Fowler Paul A, Pasanen Markku. 2016. Reproductive toxicology. 63: 22-31 A1 Journal article (refereed), original research
Maternal socioeconomic status and the risk of asthma among offspring
Harju Maijakaisa, Keski-Nisula Leea, Georgiadis Leena, Raatikainen Kaisa, Räisänen Sari, Heinonen Seppo. 2015. Bmc public health. 15: 27 A1 Journal article (refereed), original research
Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study
Karvonen AM, Hyvärinen A, Rintala H, Korppi M, Täubel M, Doekes G, Gehring U, Renz H, Pfefferle PI, Genuneit J, Keski-Nisula L, Remes S, Lampi J, von Mutius E, Pekkanen J. 2014. Allergy. 69: 1092-1101 A1 Journal article (refereed), original research
Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study
Georgiadis L, Keski-Nisula L, Harju M, Räisänen S, Georgiadis S, Hannila ML, Heinonen S. 2014. Placenta. 35: 275-280 A1 Journal article (refereed), original research
Infertility treatment and umbilical cord length-novel markers of childhood epilepsy?
Räisänen S, Sokka A, Georgiadis L, Harju M, Gissler M, Keski-Nisula L, Kälviäinen R, Heinonen S. 2013. PLoS ONE. 8: e55394 A1 Journal article (refereed), original research
Inflammatory response and IgE sensitization at early age
Mustonen K, Orivuori L, Keski-Nisula L, Hyvärinen A, Pfefferle PI, Riedler J, Dalphin JC, Genuneit J, Lauener R, Roduit C, Braun-Fahrländer C, Weber J, Schaub B, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.. 2013. Pediatric allergy and immunology. 24: 395-401 A1 Journal article (refereed), original research
Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth
Keski-Nisula L, Kyynäräinen HR, Kärkkäinen U, Karhukorpi J, Heinonen S, Pekkanen J. 2013. Acta paediatrica. 102: 480-485 A1 Journal article (refereed), original research
The Burden of Childhood Asthma and Late Preterm and Early Term Births
Harju M, Keski-Nisula L, Georgiadis L, Räisänen S, Gissler M, Heinonen S. 2013. Journal of pediatrics. [Epub ahead of print]: 1-6 A1 Journal article (refereed), original research
True umbilical cord knot and obstetric outcome
Räisänen S, Georgiadis L, Harju M, Keski-Nisula L, Heinonen S. 2013. International journal of gynecology and obstetrics. 122: 18-21 A1 Journal article (refereed), original research
Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas
Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin J-C, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J, the PASTURE Study Group. 2012. Clinical and experimental allergy. 42: 1246-1256 A1 Journal article (refereed), original research
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children
Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin JC, Buechele G, Lauener R, Braun-Fahrländer C, von Mutius E, Pekkanen J, the PASTURE Study Group, 19 jäsentä; Remes S. 2012. Pediatric allergy and immunology. 23: 522-528 A1 Journal article (refereed), original research
Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts
Bergroth, E; Remes, S; Pekkanen, J; Kauppila, T; Büchele, G; Keski-Nisula, L. 2012. Pediatrics. 130: 211-220 A1 Journal article (refereed), original research
Risk factors and adverse pregnancy outcomes among births affected by velamentous umbilical cord insertion: a retrospective population-based register study
Räisänen, S; Georgiadis, L; Harju, M; Keski-Nisula, L; Heinonen, S. 2012. European journal of obstetrics and gynecology and reproductive biology. 2012: 1-4 A1 Journal article (refereed), original research
Extra-membranous pregnancy, prolonged ruptured membranes and circumvallate placenta
Keski-Nisula L, Heiskanen P, Heinonen S. 2011. Acta obstetricia et gynecologica scandinavica. 90: 1170-1171 A1 Journal article (refereed), original research
Farming environment and prevalence of atopy at age 31: prospective birth cohort study in Finland
Lampi J, Canoy D, Jarvis D, Hartikainen AL, Keski-Nisula L, Järvelin MR, Pekkanen J. 2011. Clinical and experimental allergy. 41: 987-993 A1 Journal article (refereed), original research
Birth-related factors and doctor-diagnosed wheezing and allergic sensitization in early childhood
L Keski-Nisula, A Karvonen, PI Pfefferle, H Renz, G Büchele & J Pekkanen. 2010. Allergy. 65: 1116-1125 A1 Journal article (refereed), original research
Intrauterine bacterial growth at birth and risk of asthma and allergic sensitization among offspring at the age of 15 to 17 years
Keski-Nisula L, Katila M-L, Remes S, Heinonen S, Pekkanen J. 2009. Journal of allergy and clinical immunology. 123: 1305-1311 A1 Journal article (refereed), original research
Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring
Keski-Nisula L, Heinonen S, Remes S, Pekkanen J. 2009. American journal of reproductive immunology. 62: 293-300 A1 Journal article (refereed), original research
Vacuum-assisted delivery is associated with late-onset asthma
Keski-Nisula L, Harju M, Järvelin M-R, Pekkanen J. 2009. Allergy. 64: 1530-1538 A1 Journal article (refereed), original research
CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women
Jääskeläinen E, Toivonen S, Keski-Nisula L, Paattiniemi E-L, Helisalmi S, Punnonen K, Heinonen S. 2008. Clinical chemistry and laboratory medicine. 46: 169-173 A1 Journal article (refereed), original research
Polymorphism of the interleukin 1 receptor antatgonist (IL1Ra) gene and placental abruption
Jaaskelainen E, Keski-Nisula L, Toivonen S, Paattiniemi E-L, Helisalmi S, Punnonen K, Heinonen S. 2008. Journal of reproductive immunology. 79: 58-62 A1 Journal article (refereed), original research
Raskausajan diabetes yleistyy: liikaa energiaa, liian vähän liikuntaa ja insuliinia
Keski-Nisula L. 2008. Erikoislääkäri. 18: 45-48 A1 Journal article (refereed), original research
No association between placental weight or ratio at birth and risk of atopy, hay fever, or asthma at the age of 31 years
Keski-Nisula L, Järvelin MR, Pekkanen J. 2007. Journal of investigational allergology and clinical immunology
Placental ratio and risk of velamentous umbilical cord insertion are increased in women with placenta praevia
Papinniemi M, Keski-Nisula L, Heinonen S. 2007. American journal of perinatology. 24: 353-358 A1 Journal article (refereed), original research
Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring
Keski-Nisula L, Pekkanen J, Xu B, Putus T, Koskela P. 2006. Allergy. 61: 1467-1472 A1 Journal article (refereed), original research
MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in finnish women
Jääskeläinen E, Keski-Nisula L, Toivonen S, Romppanen E-L, Helisalmi S, Punnonen K, Heinonen S, Helisalmi S. 2006. Hypertension in pregnancy. 25: 73-80 A1 Journal article (refereed), original research
Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in finnish women
Toivonen S, Keski-Nisula L, Romppanen E-L, Helisalmi S, Punnonen K, Heinonen S. 2005. Fetal diagnosis and therapy. 20: 508-511 A1 Journal article (refereed), original research
Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia - an array study on casespecific human preeclamptic placental tissue
Heikkilä A, Tuomisto T, Häkkinen S-K, Keski-Nisula L, Heinonen S, Ylä-Herttuala S. 2005. Acta obstetricia et gynecologica scandinavica. 84: 679-689 A1 Journal article (refereed), original research
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption
Toivonen S, Romppanen E-L, Hiltunen M, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION. 11: 540-544 A1 Journal article (refereed), original research
M385T polymorphism in the factor V gene, but not leiden mutation, is associated with placental abruption in finnish women
Jääskeläinen E, Toivonen S, Romppanen E-L, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. Placenta. 25: 730-734 A1 Journal article (refereed), original research
Risk of placental abruption in first-degree relatives of index patients
Toivonen S, Keski-Nisula L, Saarikoski S, Heinonen S. 2004. Clinical genetics
Spontaneous and stimulated interleukin-6 and tumor necrosis factor-alpha production at delivery and three months after birth
Keski-Nisula L, Hirvonen M-R, Roponen M, Heinonen S, Pekkanen J. 2004. European cytokine network. 15: 67-72 A1 Journal article (refereed), original research
Stimulated cytokine production correlates in umbilical arterial venous blood at delivery
Keski-Nisula L, Roponen M, Hirvonen M-R, Heinonen S, Pekkanen J. 2004. European cytokine network. 4: 347-352 A1 Journal article (refereed), original research
Amniocentesis - a routine procedure, but invasive
Poutamo J, Keski-Nisula L, Kuopio T, Heinonen S. 2003. Prenatal diagnosis
Maternal and neonatal IL-4 and IFN-gamma production at delivery and 3 months after birth
Keski-Nisula L, Hirvonen M-R, Roponen M, Heinonen S, Pekkanen J. 2003. Journal of reproductive immunology. 60: 25-33 A1 Journal article (refereed), original research
Myometrial inflammation in human delivery and its association with labor and infection
Keski-Nisula LT, Aalto M-L, Kirkinen PP, Kosma V-M, Heinonen ST. 2003. American journal of clinical pathology. 120: 217-224 A1 Journal article (refereed), original research
Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes
Laurema A, Heikkilä A, Keski-Nisula L, Heikura T, Lehtolainen P, Manninen H, Tuomisto TT, Heinonen S, Ylä-Herttuala S. 2003. Gene therapy. : 580-584 A1 Journal article (refereed), original research
Gene transfer to human placenta ex vivo: A novel application of dual perfusion of human placental cotyledon
Heikkilä A, Myllynen P, Keski-Nisula L, Heinonen S, Vähäkangas K, Ylä-Herttuala S. 2002. American journal of obstetrics and gynecology. 186: 1046-1051 A1 Journal article (refereed), original research
Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes
Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Gene therapy. 8: 784-788 A1 Journal article (refereed), original research
Intrauterine inflammation at term: a histopathologic study
Keski-Nisula L, Aalto M-L, Katila M-L, Kirkinen P. 2000. Human pathology. 31: 841-846 A1 Journal article (refereed), original research
Prenatal collapse of cysts in a dysplastic kidney
Keski-Nisula L, Kiekara O, Kirkinen P. 1999. Journal of clinical ultrasound. 27: 356-360 A1 Journal article (refereed), original research
Selvittämätön syöpä ja luustoetäpesäkkeet
Keski-Nisula L, Katila M-L, Virén M, Kataja V, Katila T. 1998. Duodecim. 114: 777-781 A1 Journal article (refereed), original research
Amniotic fluid U. urealyticum colonization: Significance for maternal peripartal infections at term
Keski-Nisula L, Kirkinen P, Katila M-L, Ollikainen M, Suonio S, Saarikoski S. 1997. American journal of perinatology. 14: 151-156 A1 Journal article (refereed), original research
Amniotic fluid leukocytes and leukocyte esterase activity in parturients delivered by caesarean section
Keski-Nisula L, Katila M-L, Kirkinen P, Ollikainen M, Saarikoski S. 1997. Scandinavian journal of infectious diseases. 29: 291-296 A1 Journal article (refereed), original research
C-reactive protein in uncomplicated parturients delivered by cesarean section
Keski-Nisula L, Kirkinen P, Ollikainen M, Saarikoski S. 1997. Acta obstetricia et gynecologica scandinavica. 76: 862-867 A1 Journal article (refereed), original research
Cesarean delivery: Microbial colonization in amniotic fluid
Keski-Nisula L, Kirkinen P, Katila M-L, Ollikainen M, Saarikoski S. 1997. Journal of reproductive medicine. 42: 91-98 A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Leea Keski-Nisula

Research groups

Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth

Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study

Earlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns

Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy

Maternal exercise during pregnancy is associated with reduced risk of asthma in the child: A prospective birth cohort study

Ravintolisien käyttö raskauden aikana Pohjois-Savossa

Trajectories of Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Perinatal Outcomes: A Longitudinal Register Study

Associations of gestational anxiety and depression with neonatal hair steroid levels

Delayed umbilical cord clamping in elective and nonelective term Cesarean delivery

Fear of Childbirth Impairs Breastfeeding Success Independent of Mode of Birth

Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort

Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort

Maternal dietary indexes are not linked to early childhood wheezing or atopic eczema

Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood

Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies

The association between gestational diabetes and fear of childbirth: a longitudinal register study

Umbilical arterial lactate levels after normal vaginal and elective cesarean delivery: The role of a longer active second stage most significant in high levels after vaginal delivery

Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism

High estradiol levels during a long agonist IVF protocol are associated with decreased food intake, higher leptin concentrations, and lower levels of high-sensitivity C-reactive protein

Quetiapine and other antipsychotic medications during pregnancy: a 15-year follow-up of a university hospital birth register

Vulvovaginal yeast infections, gestational diabetes and pregnancy outcome

Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy

Imukuppiavusteinen synnytys KYS:ssa

Longitudinal Analyses of Diet Quality and Maternal Depressive Symptoms During Pregnancy: The Kuopio Birth Cohort Study

Perinatal factors and high-sensitive C-reactive protein levels during adolescence

Self‐reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies

Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol

Farm environment during pregnancy and childhood and polysensitization at the age of 31 - Prospective birth cohort study in Finland

Fetal lactate levels align with the stage of labour

Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence?

Robotic-assisted laparoscopy is a feasible method for resection of deep infiltrating endometriosis, especially in the rectosigmoid area

The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study

Caffeine content in newborn hair correlates with maternal dietary intake

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Hypothyroidism and the increased risk of preeclampsia - interpretative factors?

Lapsettomuushoidon ensikäynnistä kaksi vuotta. Yli puolelle hoidetuista lapsi

Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors

The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol

Bakteeri-infektiot

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Kunnankätilö Makkosen hoitamat kotisynnytykset Pohjois-Savossa vuonna 1958

Maternal use of drugs and preeclampsia

Raskaudenaikaiset infektiot

The dynamic course of peripartum depression across pregnancy and childbirth

Virusinfektiot

Zoonoosit

Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women

Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child

Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring

The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study

Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: A population-based study

The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life

Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy

Parental smoking and cessation during pregnancy and the risk of childhood asthma

The human placental proteome is affected by maternal smoking

Maternal socioeconomic status and the risk of asthma among offspring

Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study

Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study

Infertility treatment and umbilical cord length-novel markers of childhood epilepsy?

Inflammatory response and IgE sensitization at early age

Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth

The Burden of Childhood Asthma and Late Preterm and Early Term Births

True umbilical cord knot and obstetric outcome

Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas

Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children

Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Risk factors and adverse pregnancy outcomes among births affected by velamentous umbilical cord insertion: a retrospective population-based register study

Extra-membranous pregnancy, prolonged ruptured membranes and circumvallate placenta

Farming environment and prevalence of atopy at age 31: prospective birth cohort study in Finland

Birth-related factors and doctor-diagnosed wheezing and allergic sensitization in early childhood

Intrauterine bacterial growth at birth and risk of asthma and allergic sensitization among offspring at the age of 15 to 17 years

Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring

Vacuum-assisted delivery is associated with late-onset asthma

CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women

Polymorphism of the interleukin 1 receptor antatgonist (IL1Ra) gene and placental abruption

Raskausajan diabetes yleistyy: liikaa energiaa, liian vähän liikuntaa ja insuliinia

No association between placental weight or ratio at birth and risk of atopy, hay fever, or asthma at the age of 31 years