Maija Vaittinen

Indole-3-propionic acid promotes hepatic stellate cells inactivation

Ilha, Mariana; Sehgal, Ratika; Matilainen, Johanna; Rilla, Kirsi; Kaminska, Dorota; Gandhi, Shrey; Männistö, Ville; Ling, Charlotte; Romeo, Stefano; Pajukanta, Päivi; Pirinen, Eija; Virtanen, Kirsi A.; Pietiläinen, Kirsi H.; Vaittinen, Maija; Pihlajamäki, Jussi, 2025, Journal of translational medicine, 23, 1, 253. A1 Journal article (refereed), original research

The effect of aldafermin expressing-Escherichia coli Nissle 1917 along with dietary change on visceral adipose tissue in MASLD mouse model

Iannone, Valeria; Vaittinen, Maija; Gómez-Gallego, Carlos; Mikkonen, Santtu; Lok, Johnson; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Tikkanen, Ida; Sommer, Morten Otto Alexander; El-Nezami, Hani; Kolehmainen, Marjukka, 2025, International journal of obesity, 49, 7, 1334-1344. A1 Journal article (refereed), original research

Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity

Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P.; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U.; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi, 2024, Journal of translational medicine, 22, 1, 623. A1 Journal article (refereed), original research

Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet - an exploratory study

Vaittinen, Maija; Ilha, Mariana; Sehgal, Ratika; Lankinen, Maria A; Ågren, Jyrki; Käkelä, Pirjo; Virtanen, Kirsi A; Laakso, Markku; Schwab, Ursula; Pihlajamäki, Jussi, 2024, Journal of lipid research, 65, 10, 100638. A1 Journal article (refereed), original research

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Iannone, Valeria; Babu, Ambrin Farizah; Lok, Johnson; Gómez-Gallego, Carlos; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Vaaben, Troels Holger; Bongers, Mareike; Mikkonen, Santtu; Vaittinen, Maija; Tikkanen, Ida; Kettunen, Mikko; Klåvus, Anton; Sehgal, Ratika; Kaminska, Dorota; Pihlajamaki, Jussi; Hanhineva, Kati; El-Nezami, Hani; Alexander Sommer, Morten Otto; Kolehmainen, Marjukka, 2023, Molecular metabolism, 78, 101823. A1 Journal article (refereed), original research

Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro

Vaittinen, Maija; Ilha, Mariana; Herbers, Elena; Wagner, Anita; Virtanen, Kirsi A; Pietiläinen, Kirsi H; Pirinen, Eija; Pihlajamäki, Jussi, 2023, Diabetes research and clinical practice, 199, 110635. A1 Journal article (refereed), original research

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

Vaittinen, Maija; Lankinen, Maria A; Käkelä, Pirjo; Ågren, Jyrki; Wheelock, Craig E; Laakso, Markku; Schwab, Ursula; Pihlajamäki, Jussi, 2022, European journal of nutrition, 61, 7, 3707-3718. A1 Journal article (refereed), original research

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

van der Kolk, Birgitta; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel; Männistö, Ville; Saris, Wim; Astrup, Arne; Rydén, Mikael; Blaak, Ellen; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H, 2021, Journal of clinical endocrinology and metabolism, 106, 5, 1312-1324. A1 Journal article (refereed), original research

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Sehgal, Ratika Ilha, Mariana Vaittinen, Maija Kaminska, Dorota Männistö, Ville Kärjä, Vesa Tuomainen, Marjo Hanhineva, Kati Romeo, Stefano Pajukanta, Päivi Pihlajamäki, Jussi de Mello, Vanessa D., 2021, Nutrients, 13, 10, 3509. A1 Journal article (refereed), original research

Liver DNA methylation of FADS2 associates with FADS2 genotypex

Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J, 2019, Clinical epigenetics, 11, 1, 10. A1 Journal article (refereed), original research

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi, 2018, Bioscience reports, 38, 2, 1-9. A1 Journal article (refereed), original research

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB

Käkelä, Pirjo; Männistö, Ville; Vaittinen, Maija; Venesmaa, Sari; Kärjä, Vesa; Virtanen, Kirsi; Paajanen, Hannu; Pihlajamäki, Jussi, 2018, Obesity surgery, 28, 12, 3969-3975. A1 Journal article (refereed), original research

Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: Effects of bariatric surgery

Dadson P, Ferrannini E, Landini L, Hannukainen JC, Kalliokoski KK, Vaittinen M, Honka H, Karlsson HK, Tuulari JJ, Soinio M, Salminen P, Parkkola R, Pihlajamäki J, Iozzo P, Nuutila P, 2017, American journal of physiology : endocrinology and metabolism, 313, 2, E175-E182. A1 Journal article (refereed), original research

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity

Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J, 2017, Obesity, 25, 3, 545-552. A1 Journal article (refereed), original research

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi, 2016, Metabolism: clinical and experimental, 65, 5, 655-666. A1 Journal article (refereed), original research

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Vaittinen Maija, Walle Paula, Kuosmanen Emmi, Männistö Ville, Käkelä Pirjo, Ågren Jyrki, Schwab Ursula, Pihlajamäki Jussi, 2015, Journal of lipid research, 2016; 57, 56-65. A1 Journal article (refereed), original research

Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men

Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI, 2015, Molecular nutrition and food research, 2016; 60, 2, 381-389. A1 Journal article (refereed), original research

MFAP5 is Related to Obesity-Associated Adipose Tissue and Extracellular Matrix Remodeling and Inflammation

Vaittinen Maija, Kolehmainen Marjukka, Rydén Mikael, Eskelinen Matti, Wabitsch Martin, Pihlajamäki Jussi, Uusitupa Matti, Pulkkinen Leena, 2015, Obesity, 23, 7, 1371-1378. A1 Journal article (refereed), original research

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Vaittinen M, Kaminska D, Käkelä P, Eskelinen M, Kolehmainen M, Pihlajamäki J, Uusitupa M, Pulkkinen L, 2013, Diabetes, 62, 3747-3750. A1 Journal article (refereed), original research

The role of weight reduction sensitive genes on adipose Tissue Biology and adipocyte function : special emphasis on the expression of MFAP5 and CPPED1

Vaittinen Maija, 2013, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J, 2012, Diabetes, 61, 2807-2813. A1 Journal article (refereed), original research

Microfibrillar-associated protein 5 is linked with markers of obesity-related extracellular matrix remodeling and inflammation

Vaittinen M, Kolehmainen M, Schwab U, Uusitupa M, Pulkkinen L, 2011, Nutrition and diabetes, 1, e15, 1-6. A1 Journal article (refereed), original research

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Indole-3-propionic acid promotes hepatic stellate cells inactivation

The effect of aldafermin expressing-Escherichia coli Nissle 1917 along with dietary change on visceral adipose tissue in MASLD mouse model

Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity

Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet - an exploratory study

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Liver DNA methylation of FADS2 associates with FADS2 genotypex

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB

Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: Effects of bariatric surgery

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men

MFAP5 is Related to Obesity-Associated Adipose Tissue and Extracellular Matrix Remodeling and Inflammation

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

The role of weight reduction sensitive genes on adipose Tissue Biology and adipocyte function : special emphasis on the expression of MFAP5 and CPPED1

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Microfibrillar-associated protein 5 is linked with markers of obesity-related extracellular matrix remodeling and inflammation