Maria Hytti

Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery

Harju, Niina; Hytti, Maria; Kolari, Onni; Nisula, Hilkka; Loukovaara, Sirpa; Kauppinen, Anu. 2024. International ophthalmology. 44: . 158 A1 Journal article (refereed), original research

Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells

Mysore, Yashavanthi; Hytti, Maria; Deen, Ashik Jawahar; Ranta-aho, Sofia; Piippo, Niina; Toppila, Maija; Loukovaara, Sirpa; Harju, Niina; Kauppinen, Anu. 2024. Cell biochemistry and biophysics. 82: 1523-1536 A1 Journal article (refereed), original research

Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage

Toppila, Maija; Ranta-aho, Sofia; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2024. Cells. 13: A1 Journal article (refereed), original research

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Liukkonen, Mikko; Heloterä, Hanna; Siintamo, Leea; Ghimire, Bishwa; Mattila, Pirkko; Kivinen, Niko; Kostanek, Joanna; Watala, Cezary; Hytti, Maria; Hyttinen, Juha; Koskela, Ali; Blasiak, Janusz; Kaarniranta, Kai. 2024. Investigative ophthalmology and visual science. 65: A1 Journal article (refereed), original research

Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2023. Biochemical pharmacology. 216: A1 Journal article (refereed), original research

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai. 2023. Journal of biological chemistry. 299: A1 Journal article (refereed), original research

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Toppila, Maija; Hytti, Maria; Korhonen, Eveliina; Ranta-aho, Sofia; Harju, Niina; Forsberg, Markus M.; Kaarniranta, Kai; Jalkanen, Aaro; Kauppinen, Anu. 2023. Antioxidants. 12: A1 Journal article (refereed), original research

Amfenac together with simvastatin reduces IL-8 and MCP-1 and increases VEGF release from ARPE-19 cells upon inflammatory conditions

Bhattarai, Niina; Hytti, Maria; Kolari, Onni; Nisula, Hilkka; Loukovaara, Sirpa; Kauppinen, Anu. 2022. Acta ophthalmologica abstract

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Sridevi Gurubaran, Iswariyaraja; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2022. Antioxidants. 11: A1 Journal article (refereed), original research

Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration

Bhattarai, Niina; Hytti, Maria; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2022. Acta ophthalmologica abstract

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

Bhattarai, Niina; Hytti, Maria; Reinisalo, Mika; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2022. Immunologic research. 70: 678-687 A1 Journal article (refereed), original research

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells

Hytti, Maria; Ruuth, Johanna; Kanerva, Iiris; Bhattarai, Niina; Pedersen, Maria L; Nielsen, Carsten U; Kauppinen, Anu. 2022. Molecular and cellular biochemistry. 2023; 478: 215-227 A1 Journal article (refereed), original research

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu. 2021. Experimental eye research. 209: 108687 A1 Journal article (refereed), original research

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration

Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu. 2021. International journal of molecular sciences. 22: 6800 A1 Journal article (refereed), original research

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2021. International journal of molecular sciences. 22: 4875 A1 Journal article (refereed), original research

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Faseb journal. 34: 6437-6448 A1 Journal article (refereed), original research

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. Investigative ophthalmology and visual science. 61: 7 A1 Journal article (refereed), original research

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Oxidative medicine and cellular longevity. 2019: 1583656 A1 Journal article (refereed), original research

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells

Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. 2019. Cytokine. 116: 70-77 A1 Journal article (refereed), original research

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. 2018. Scientific reports. 8: 6720 A1 Journal article (refereed), original research

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular physiology and biochemistry. 49: 359-367 A1 Journal article (refereed), original research

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. Scientific reports. 7: 16169 A1 Journal article (refereed), original research

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. 2017. Journal of cell communication and signaling. 11: 275-279 A1 Journal article (refereed), original research

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy

Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. 2017. Acta ophthalmologica. 95: 803-808 A1 Journal article (refereed), original research

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Journal of nutritional biochemistry. 42: 37-42 A1 Journal article (refereed), original research

Inflammation in Age-related Macular Degeneration and its Regulation by Sirtuin Ligands

Hytti Maria. 2016. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)

Inhibition of BET bromodomains alleviates inflammation in human RPE cells

Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. 2016. Biochemical pharmacology. 110-111: 71-79 A1 Journal article (refereed), original research

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation

Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Scientific reports. 5: A1 Journal article (refereed), original research

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Experimental eye research. 132: 208-215 A1 Journal article (refereed), original research

CB2 receptor as a potential target in age-related diseases

Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. Journal of biochemical and pharmacological research. 2: 33-43 A2 Review article, Literature review, Systematic review

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

Yrjölä Sari, Sarparanta Mirkka, Airaksinen Anu J, Hytti Maria, Kauppinen Anu, Pasonen-Seppänen Sanna, Adinolfi Barbara, Nieri Paola, Manera Clementina, Keinänen Outi, Poso Antti, Nevalainen Tapio J, Parkkari Teija. 2014. European journal of pharmaceutical sciences. 2015; 67: 85-96 A1 Journal article (refereed), original research

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy

Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Clinical ophthalmology. 8: 799-805 A1 Journal article (refereed), original research

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Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery

Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells

Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Amfenac together with simvastatin reduces IL-8 and MCP-1 and increases VEGF release from ARPE-19 cells upon inflammatory conditions

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell

Inflammation in Age-related Macular Degeneration and its Regulation by Sirtuin Ligands

Inhibition of BET bromodomains alleviates inflammation in human RPE cells

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

CB2 receptor as a potential target in age-related diseases

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy