Minna Sivonen
Doctoral Researcher
Department of Technical Physics, Faculty of Science, Forestry and Technology
My research focuses on developing next-generation cancer immunotherapies, with a particular emphasis on biomimetic cancer nanovaccines. We utilize virus-like mesoporous silica nanoparticles (VLNPs) designed to mimic viral structures and enhance immune system activation. By optimizing the surface features of these nanoparticles and incorporating cancer cell membranes, we aim to stimulate the immune response against cancer, more specifically activation of NK and T cells.
Research groups
Publications
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Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy
Happonen, Emilia; Dang, Yijing; Wang, Jiajia; Saarela, Silja; Sivonen, Minna; Zakir, Mohammed; Laari, Milla-Iida; Constantinou, Yiannis; Tamarov, Konstantin; Hakkarainen, Henri; Montaser, Ahmed Bisher; Leinonen, Henri; Küblbeck, Jenni; Örd, Tiit; Taipale, Mari; Kaikkonen, Minna; Liu, Ruixian; Klefström, Juha; Yu, Haijun; Xu, Zhiai; Lehto, Vesa-Pekka; Xu, Wujun. 2025. Acs applied materials and interfaces. 17: 46521-46534 A1 Journal article (refereed), original research -
Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro
Sivonen, Minna; Sirviö, Katja A; Wojciechowski, Sara; Kailaanmäki, Anssi; Kaipainen, Satu; Bailey, Aubrey; Villalba, Martin; Kekarainen, Tuija. 2023. Frontiers in immunology. 2023; 14: 1-13 A1 Journal article (refereed), original research