Neuromodulation research group

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Research group

01.01.2017 -

Department of Technical Physics, Faculty of Science, Forestry and Technology

Information People Publications

Leaders

Petro Julkunen

Professor

Department of Technical Physics, Faculty of Science, Forestry and Technology

Our research focuses on the neuromodulation, functional imaging, theoretical assessment and biomechanical measurement of the neuromuscular function connecting the human brains to motion, developing new pre-clinical and clinical methods especially for neurophysiology diagnostics and treatments, and understanding multisensory effects on the excitability of the brain. Our main focus is in the quantitative analysis motor function, and motor cortical control of muscle action. In addition, we have a general focus on methodological development of the navigated transcranial magnetic stimulation methodology, technology and response analysis tools to improve the accuracy and applicability of mapping the motor function as well as increasing the efficiency of neuromodulation treatments with navigated repetitive transcranial magnetic stimulation (rTMS).

The key methods we apply and develop are navigated transcranial magnetic stimulation, electroneuromyography, electroencephalography (TMS-EEG), modeling of neural function, motion analysis, radiological imaging and biomechanical tests and modeling. We actively collaborate with other national and international research groups, and companies. Our research group includes members who are specialists in medicine, physics, health sciences and biomedical engineering. Neuromodulation research group also operates as a member of the ”Musculoskeletal diseases”, ”Computational Modelling, Imaging and Data Science” and ”Neuroscience” research communities.

We are funded by:

Research Council of Finland
Doctoral programme in Science, Technology and Computing (SCITECO)
State research funding
Orion Research Foundation
Other private foundations
Research and development contracts with companies

News

Team for TMS-EEG formed to develop reproducibility of TMS-EEG

T4TE provides a framework for the TMS-EEG community to join in an international collaborative effort, with the aim of improving the quality of TMS-EEG…

Team for TMS-EEG formed to develop reproducibility of TMS-EEG

Cooperation

Nexstim Plc

Manufacturer of neuromodulation systems
Bittium Ltd

Medical technology company and manufacturer of TMS-EEG systems
Professor Vasilios Kimiskidis

Department of Neurology, Aristotle University of Thessaloniki, Greece
Professor Emer. Risto Ilmoniemi

Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo
Assistant Professor Elisa Kallioniemi, PhD

New Jersey Institute of Technology, New Jersey, USA
Professor Reetta Kälviäinen

University of Eastern Finland / Epilepsy Center, Kuopio University Hospital, Kuopio, Finland
Professor Petteri Nieminen

School of Medicine, University of Eastern Finland
Team for TMS-EEG (T4TE)
Professor Aarno Dietz

Department of Otolaryngology, Kuopio University Hospital, Kuopio, Finland
Professor Rami Korhonen
Associate Professor Lauri Stenroth
Professor Pasi Karjalainen
Medical specialist, researcher Selja Vaalto
Professor Satu Jääskeläinen
Senior Researcher Pantelis Lioumis

ATH-tool available for download

ATH-tool can now be downloaded for Android-systems via the link below:

ATHtoolv44.apk

See the original article, and please cite upon use.

https://doi.org/10.1109/TNSRE.2019.2925904

MEPFeatX—automated feature extraction of motor-evoked potentials in transcranial magnetic stimulation

MEPFeatX is made openly available via GitHub: https://github.com/NeuromodulationUEF/MEPFeatX

and sample dataset are available here: https://erepo.uef.fi/handle/123456789/30114

Please cite the original article upon use.

https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1415257/abstract

Keywords

biomechanics brain brain imaging brain research clinical neurophysiology motion analysis motor-evoked potential muscle neuroimaging plasticity

Leaders

Petro Julkunen

Professor

Department of Technical Physics, Faculty of Science, Forestry and Technology

Professors

Sara Määttä

Professor

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

Senior Researchers

Post-doctoral Researchers

Doctoral Researchers

Other group members

Minna Pitkänen post-doctoral researcher
Jani Sirkka doctoral student
Mervi Könönen associate professor
Jari Karhu associate professor
Joel Naukkarinen doctoral student
Stephan Geiger doctoral student

Publications

84 items

Refine your search

Neuromodulation research group

Leaders

Petro Julkunen

News

Team for TMS-EEG formed to develop reproducibility of TMS-EEG

Cooperation

ATH-tool available for download

MEPFeatX—automated feature extraction of motor-evoked potentials in transcranial magnetic stimulation

Keywords

Leaders

Petro Julkunen

Professors

Sara Määttä

Senior Researchers

Laura Säisänen

Nils Danner

Jelena Hyppönen

Post-doctoral Researchers

Amir Esrafilian

Paavo Vartiainen

Jusa Reijonen

Atte Seppo Aleksi Eskelinen

Doctoral Researchers

Dao Nguyen

Zunaira Jamil

Linda Kukola

Lauri Karttunen

Other group members

Accuracy assessment of a cochlear implant imaging tool using clinical computed tomography images

An Electromyography-Assisted Musculoskeletal Simulation With Concurrent Optimization of Muscle Excitations and Knee Joint Kinematics

Bridging the gap to clinical use: A systematic review on TMS–EEG test-retest reliability

MEPFeatX—automated feature extraction of motor-evoked potentials in transcranial magnetic stimulation

Pain and functional limitations in knee osteoarthritis are reflected in the fatty acid composition of plasma extracellular vesicles

Plasma Amino Acids Reflect Cartilage Loss, Osteoarthritis Pain, Functional Disability, and Mental Health in a Longitudinal Study with Total Knee Replacement

An Automated and Robust Tool for Musculoskeletal and Finite Element Modeling of the Knee Joint

Feature extraction of motor-evoked potentials in transcranial magnetic stimulation

Hyaluronic Acid and Large Extracellular Vesicles (EVs) in Synovial Fluid and Plasma of Patients With End-Stage Arthritis: Positive Association of EVs to Joint Pain

Navigated and individual α-peak-frequency–guided transcranial magnetic stimulation in male patients with treatment-refractory schizophrenia

Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis

The Effect of Stimulation Intensity, Sampling Frequency, and Sample Synchronization in TMS-EEG on the TMS Pulse Artifact Amplitude and Duration

Automatic electrode scalar location assessment after cochlear implantation using a novel imaging software

Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood

Near-threshold recruitment characteristics of motor evoked potentials in transcranial magnetic stimulation

TMS combined with EEG: Recommendations and open issues for data collection and analysis

Bridging the gap: TMS-EEG from lab to clinic

Efficacy and tolerability in patients with chronic facial pain of two consecutive treatment periods of rTMS applied over the facial motor cortex, using protocols differing in stimulation frequency, duration, and train pattern

Minimum-Norm Estimation of TMS-Activated Motor Cortical Sites in Realistic Head and Brain Geometry

Short‐ and long‐interval intracortical inhibition in EPM1 is related to genotype

T4TE: Team for TMS−EEG and improve reproducibility through an open collaborative initiative

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

Atlas-informed computational processing pipeline for individual targeting of brain areas for therapeutic navigated transcranial magnetic stimulation

Fast acquisition of resting motor threshold with a stimulus-response curve - Possibility or hazard for transcranial magnetic stimulation applications?

Mapping of Motor Function with Neuronavigated Transcranial Magnetic Stimulation: A Review on Clinical Application in Brain Tumors and Methods for Ensuring Feasible Accuracy

Brain Response Induced with Paired Associative Stimulation Is Related to Repetition Suppression of Motor Evoked Potential

Corticospinal Excitability in Idiopathic Normal Pressure Hydrocephalus: A Transcranial Magnetic Stimulation Study

Paired-pulse navigated TMS is more effective than single-pulse navigated TMS for mapping upper extremity muscles in brain tumor patients

Spatial extent of cortical motor hotspot in navigated transcranial magnetic stimulation

Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS-EEG study

Mobile Application for Adaptive Threshold Hunting in Transcranial Magnetic Stimulation

Navigoitu TMS (nTMS) ja neuromodulaatio: Kliiniset käyttöaiheet

Navigoitu TMS (nTMS) ja neuromodulaatio: Laitteisto

Principal Component Regression on Motor Evoked Potential in Single-Pulse Transcranial Magnetic Stimulation

Reproducibility in TMS-EEG studies: A call for data sharing, standard procedures and effective experimental control

The effect of coil placement and orientation on the assessment of focal excitability in motor mapping with navigated transcranial magnetic stimulation

Transkraniaalinen magneettistimulaatio osana kivunhoitoa

Abnormal motor cortical adaptation to external stimulus in Unverricht-Lundborg disease (progressive myoclonus type 1, EPM1)

Aivokuoren ja kortikospinaaliradan ärtyvyyden palautuminen kuntoutumisen aikana aivohalvauksen jälkeen

Development of corticospinal motor excitability and cortical silent period from mid-childhood to adulthood - a navigated TMS study

Efficient Mapping of the Motor Cortex with Navigated Biphasic Paired-Pulse Transcranial Magnetic Stimulation

Individual Characterization of Fast Intracortical Facilitation With Paired Biphasic-Wave Tanscranial Magnetic Stimulation

Modulation of motor cortical excitability with auditory stimulation

Transcranial magnetic stimulation modulation of corticospinal excitability by targeting cortical I-waves with biphasic paired-pulses

Brain plasticity in neurosurgery

Minimum-Norm Estimation of Motor Representations in Navigated TMS Mappings

Oscillatory TMS-EEG-responses as a Measure of the Cortical Excitability Threshold

Treatment of paresis

Alternative Stimulation Intensities for Mapping Cortical Motor Area with Navigated TMS

Facilitatory effect of paired-pulse stimulation by transcranial magnetic stimulation with biphasic wave-form

Functional and structural cortical characteristics after restricted focal motor cortical infarction evaluated at chronic stage : Indications from a preliminary study