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Noora Puhakka

Noora Puhakka

Visiting Researcher

A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences

[email protected]

Information Publications

Research groups

Epilepsy Research

Projects

Neuro-Innovation 01.05.2021 - 30.04.2026

Publications

54/54 items

Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury
Kyyriäinen, Jenni; Andrade, Pedro; Ekolle Ndode-Ekane, Xavier; Manninen, Eppu; Hämäläinen, Elina; Rauramaa, Tuomas; Heiskanen, Mette; Puhakka, Noora; Immonen, Riikka; Pitkänen, Asla. 2024. Epilepsy research. 200: A1 Journal article (refereed), original research
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study
van Vliet, Erwin A; Scheper, Mirte; Mills, James D; Puhakka, Noora; Szydlowska, Kinga; Ferracin, Manuela; Lovisari, Francesca; Soukupova, Marie; Zucchini, Silvia; Srivastava, Prashant K; Johnson, Michael R; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Simonato, Michele. 2024. Epilepsia. 65: 3406-3420 A1 Journal article (refereed), original research
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Vangoor, Vamshidhar R.; Giuliani, Giuliano; de Wit, Marina; Rangel, Carolina K.; Venø, Morten T.; Schulte, Joran T.; Gomes-Duarte, Andreia; Senthilkumar, Ketharini; Puhakka, Noora; Kjems, Jørgen; de Graan, Pierre N. E.; Pasterkamp, R. Jeroen. 2024. Acta neuropathologica. 148: . 61 A1 Journal article (refereed), original research
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study
Heiskanen, Mette; Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Puhakka, Noora; Gupta, Shalini Das; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Manninen, Eppu; Smith, Gregory; Brady, Rhys D.; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R.; Jones, Nigel C.; Shultz, Sandy R.; Harris, Neil G.; Wright, David K.; Gröhn, Olli; Staba, Richard J.; O'Brien, Terence J.; Pitkänen, Asla. 2024. Epilepsia. [First published: 11 December 2024]: 1-16 A1 Journal article (refereed), original research
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury
Heiskanen, Mette; Banuelos, Ivette; Manninen, Eppu; Andrade, Pedro; Hämäläinen, Elina; Puhakka, Noora; Pitkänen, Asla. 2024. Epilepsia. 65: 3703-3716 A1 Journal article (refereed), original research
Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort
Heiskanen, Mette; Das Gupta, Shalini; Mills, James D; van Vliet, Erwin A; Manninen, Eppu; Ciszek, Robert; Andrade, Pedro; Puhakka, Noora; Aronica, Eleonora; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: A1 Journal article (refereed), original research
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1
Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla. 2023. Epilepsia. 2024; 65: 511-526 A1 Journal article (refereed), original research
Gene Expression Profile as a Predictor of Seizure Liability
Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: A1 Journal article (refereed), original research
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S. 2023. Epilepsy research. 195: A1 Journal article (refereed), original research
Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury
Puhakka, Noora; Das Gupta, Shalini; Leskinen, Sara; Heiskanen, Mette; Nattinen, Janika; Aapola, Ulla; Uusitalo, Hannu; Pitkanen, Asla. 2023. Neurotrauma reports. 4: 359-366 A1 Journal article (refereed), original research
Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies
Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla. 2023. Epilepsy research. 2024; 199: A1 Journal article (refereed), original research
Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology
Kajevu, Natallie; Lipponen, Anssi; Andrade, Pedro; Bañuelos, Ivette; Puhakka, Noora; Hämäläinen, Elina; Natunen, Teemu; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: . 14049 A1 Journal article (refereed), original research
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology
Puhakka, Noora; Das Gupta, Shalini; Vuokila, Niina; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research
Biomarkers for posttraumatic epilepsy
Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Epilepsy and behavior. 121: 107080 A2 Review article, Literature review, Systematic review
Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury
Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 1563 A1 Journal article (refereed), original research
Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury
Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla. 2021. Neuroscience. 475: 52-72 A1 Journal article (refereed), original research
Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI
Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. International journal of molecular sciences. 21: 2418 A1 Journal article (refereed), original research
Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization
Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Scientific reports. 10: 9012 A1 Journal article (refereed), original research
Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury
Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Neuroscience. 433: 21-35 A1 Journal article (refereed), original research
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation
Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Brain pathology. 30: 897-912 A1 Journal article (refereed), original research
Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats
Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Epilepsia. 61: 2035-2052 A1 Journal article (refereed), original research
Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury
Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Journal of neurotrauma. 2020; 37: 924-938 A1 Journal article (refereed), original research
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury
Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Scientific reports. 9: 20208 A1 Journal article (refereed), original research
Epilepsy biomarkers - Toward etiology and pathology specificity
Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Neurobiology of disease. 123: 42-58 A2 Review article, Literature review, Systematic review
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)
Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Neuroscience. 415: 184-200 A1 Journal article (refereed), original research
Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Epilepsy research. 151: 7-16 A1 Journal article (refereed), original research
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis
Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Epilepsy research. 156: 106110 A1 Journal article (refereed), original research
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research. 150: 46-57 A1 Journal article (refereed), original research
Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis
Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Epilepsy research. 156: 106131 A1 Journal article (refereed), original research
Lateral fluid-percussion injury leads to pituitary atrophy in rats
Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports. 9: 11819 A1 Journal article (refereed), original research
Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis
Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Epilepsy research. 2019; 149: 92-101 A1 Journal article (refereed), original research
Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Epilepsy research. 2019; 150: 17-26 A1 Journal article (refereed), original research
Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs
Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Journal of extracellular vesicles. 2019; 8: 1555410 A1 Journal article (refereed), original research
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819 A1 Journal article (refereed), original research
Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury
Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Acta neuropathologica communications. 6: 17 A1 Journal article (refereed), original research
miR-124-3p is a chronic regulator of gene expression after brain injury
Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. Cellular and molecular life sciences. 75: 4557-4581 A1 Journal article (refereed), original research
Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury
Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. PLoS ONE. 12: e0172521 A1 Journal article (refereed), original research
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Epilepsia. 2018; 59: 37-66 A2 Review article, Literature review, Systematic review
Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs
van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Epilepsia. 58: 2013-2024 A2 Review article, Literature review, Systematic review
Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets
Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Scientific reports. 6: 31570 A1 Journal article (refereed), original research
Epileptogenesis after traumatic brain injury in Plaur-deficient mice
Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epilepsy and behavior. 60: 187-196 A1 Journal article (refereed), original research
Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy
Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Scientific reports. 6: 25668 A1 Journal article (refereed), original research
Epileptogenesis after traumatic brain injury in Plau-deficient mice
Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epilepsy and behavior. 51: 19-27 A1 Journal article (refereed), original research
Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury
Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Neuropharmacology. 2014 Sep 16: pii: S0028-3908(14)00306-2 A1 Journal article (refereed), original research
GABAergic network alterations in rat models of acquired epilepsy
Huusko Noora. 2014. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)
Gender issues in antiepileptogenic treatments
Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Neurobiology of disease. 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6 A1 Journal article (refereed), original research
Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI
Huusko N, Pitkänen A. 2014. Neuroscience. : 30-45. A1 Journal article (refereed), original research
Posttraumatic epilepsy - Disease or comorbidity?
Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior. 2014 Feb 11.: -- A2 Review article, Literature review, Systematic review
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy
Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Brain structure and function. 2015; 220: 153-191 A1 Journal article (refereed), original research
The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts
Belt H, Huusko N, Kaminska D, Munoz Ruiz M, Paasonen J, Pellinen R. 2013. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto C2 Edited book, conference proceedings or special issue of a journal
The Sixth Annual Post-Graduate Symposium of the Doctoral Program in Molecular Medicine: Winter School 2012. Abstracts
Natunen T, Belt H, Huusko N, Jääskeläinen A, Sutinen P, Pellinen R. 2012. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Eastern Finland University Library/ Sales of Publications C2 Edited book, conference proceedings or special issue of a journal
Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats
Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Neuroscience. 194: 208-219 A1 Journal article (refereed), original research
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus
Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Neuroscience. 163: 316-328 A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Noora Puhakka

Research groups

Projects

Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury

Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study

Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy

Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study

Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury

Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort

Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1

Gene Expression Profile as a Predictor of Seizure Liability

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury

Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology

Biomarkers for posttraumatic epilepsy

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI

Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats

Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Epilepsy biomarkers - Toward etiology and pathology specificity

Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Lateral fluid-percussion injury leads to pituitary atrophy in rats

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

miR-124-3p is a chronic regulator of gene expression after brain injury

Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets

Epileptogenesis after traumatic brain injury in Plaur-deficient mice

Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy

Epileptogenesis after traumatic brain injury in Plau-deficient mice

Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury

GABAergic network alterations in rat models of acquired epilepsy

Gender issues in antiepileptogenic treatments

Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI

Posttraumatic epilepsy - Disease or comorbidity?

Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy

The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts

The Sixth Annual Post-Graduate Symposium of the Doctoral Program in Molecular Medicine: Winter School 2012. Abstracts

Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats

Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus