Paavo Honkakoski has a long experience in regulation of drug metabolizing enzymes, drug transporters and nuclear receptors and their applications to assess drug ADMET properties. He is involved in the UEF research community “DrugTech” and a participant in the H2020 and Horizon Europe consortia EDCMET and NEMESIS. He has accumulated over 3 M€ competitive research funding. He has over 124 peer-reviewed papers garnering >6000 citations. He is active in both graduate and PhD education, having supervised >50 MSc and 11 PhD theses. He is a member of several editorial boards in journals related to drug research. He has served as a director of Graduate Schools/Doctoral Programs in drug research (2008-2017) and Vice Dean of the Faculty of Health Sciences at UEF with responsibilities in research infrastructures and doctoral programs (2012-2017).
Research groups
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Metabolism and transport of drugs and xenobiotics 01.01.2010 - -
Ocular Drug Delivery group (ODD) 01.01.2010 -
Projects
Files
1 itemsPublications
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Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD
Murphy, William A; Diehl, Anna Mae; Loop, Matthew Shane; Fu, Dong; Guy, Cynthia D; Abdelmalek, Manal F; Karachaliou, Georgia Sofia; Sjöstedt, Noora; Neuhoff, Sibylle; Honkakoski, Paavo; Brouwer, Kim L R. 2024. Hepatology communications. 8: . e0377 A1 Journal article (refereed), original research -
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol
Rashidian, Azam; Dusek, Jan; Drastik, Martin; Smutna, Lucie; Fritsche, Kristin; Braeuning, Albert; Pijnenburg, Dirk; van Beuningen, Rinie; Honkakoski, Paavo; Poso, Antti; Kronenberger, Thales; Pavek, Petr. 2024. Environmental science and technology. 58: 6913-6923 A1 Journal article (refereed), original research -
Ocular Drug-Metabolizing Enzymes: Focus on Esterases
Hammid, Anam; Honkakoski, Paavo. 2024. Drug metabolism reviews. [Epub ahead of print 19 June 2024]: 1-15 A2 Review article, Literature review, Systematic review -
Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues
Hammid, Anam; Fallon, John K; Vellonen, Kati Sisko; Lassila, Toni; Reinisalo, Mika; Urtti, Arto; Gonzalez, Francisco; Tolonen, Ari; Smith, Philip C; Honkakoski, Paavo. 2023. European journal of pharmaceutical sciences. 191: . 106603 A1 Journal article (refereed), original research -
Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
Saran, Chitra; Ho, Henry; Honkakoski, Paavo; Brouwer, Kim LR. 2023. Frontiers in pharmacology. 14: . 1147495 A1 Journal article (refereed), original research -
Farmasian teknologia ja biofarmasia
Honkakoski, Paavo; Laitinen, Riikka. 2023. Publications of the University of Eastern Finland. General series. 44: 38-43 E1 Popularised article, newspaper article -
Mass spectrometry in ocular drug research
del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32 A2 Review article, Literature review, Systematic review -
A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity
Saran, Chitra; Fu, Dong; Ho, Henry; Klein, Abigail; Fallon, John K.; Honkakoski, Paavo; Brouwer, Kim L. R. . 2022. Scientific reports. 12: . 14333 A1 Journal article (refereed), original research -
Activity and expression of carboxylesterases and arylacetamide deacetylase in human ocular tissues
Hammid, Anam; Fallon, John K; Lassila, Toni; Vieiro, Paula; Balla, Anusha; Gonzalez, Francisco; Urtti, Arto; Smith, Philip C; Tolonen, Ari; Honkakoski, Paavo. 2022. Drug metabolism and disposition. 50: 1483-1492 A1 Journal article (refereed), original research -
Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
Saran, Chitra; Sundqvist, Louise; Ho, Henry; Niskanen, Jonna; Honkakoski, Paavo; Brouwer, Kim LR. 2022. Journal of pharmacology and experimental therapeutics. 380: 114-125 A1 Journal article (refereed), original research