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Pasi-Petri Tavi

Pasi-Petri Tavi

Professor

A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences

pasi.tavi@uef.fi

Information Publications

Research groups

In vitro and ex vivo electrophysiology core facil… 01.01.2020 -
Molecular Physiology 01.01.2009 -

Publications

61/61 items

Presenilin-1 ΔE9 mutation associated sarcoplasmic reticulum leak alters [Ca2+]i distribution in human iPSC-derived cardiomyocytes
Naumenko, Nikolay; Koivumäki, Jussi T; Lunko, Olesia; Tuomainen, Tomi; Leigh, Robert; Rabiee, Mina; Laurila, Jalmari; Oksanen, Minna; Lehtonen, Sarka; Koistinaho, Jari; Tavi, Pasi. 2024. Journal of molecular and cellular cardiology. 193: 78-87 A1 Journal article (refereed), original research
Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease
Linna-Kuosmanen, Suvi; Schmauch, Eloi; Galani, Kyriakitsa; Ojanen, Johannes; Boix, Carles A; Örd, Tiit; Toropainen, Anu; Singha, Prosanta K; Moreau, Pierre R; Harju, Kristiina; Blazeski, Adriana; Segerstolpe, Åsa; Lahtinen, Veikko; Hou, Lei; Kang, Kai; Meibalan, Elamaran; Agudelo, Leandro Z; Kokki, Hannu; Halonen, Jari; Jalkanen, Juho; Gunn, Jarmo; MacRae, Calum A; Hollmén, Maija; Hartikainen, Juha EK; Kaikkonen, Minna U; García-Cardeña, Guillermo; Tavi, Pasi; Kiviniemi, Tuomas; Kellis, Manolis. 2024. Cell reports medicine. 5: . 101556 A1 Journal article (refereed), original research
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Perdreau-Dahl, Harmonie; Lipsett, David B; Frisk, Michael; Kermani, Fatemeh; Carlson, Cathrine R; Brech, Andreas; Shen, Xin; Bergan-Dahl, Anna; Hou, Yufeng; Tuomainen, Tomi; Tavi, Pasi; Jones, Peter P; Lunde, Marianne; Wasserstrom, J Andrew.; Laporte, Jocelyn; Ullrich, Nina D; Christensen, Geir; Morth, J Preben; Louch, William E. 2023. Circulation research. 132: e188-e205 A1 Journal article (refereed), original research
PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice
Naumenko, Nikolay; Mutikainen, Maija; Holappa, Lari; Ruas, Jorge L; Tuomainen, Tomi; Tavi, Pasi. 2022. Cardiovascular research. 118: 1520-1534 A1 Journal article (refereed), original research
PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes
Tuomainen, Tomi; Naumenko, Nikolay; Mutikainen, Maija; Shakirzyanova, Anastasia; Sczelecki, Sarah; Estall, Jennifer L.; Ruas, Jorge L.; Tavi, Pasi. 2022. Cells. 11: A1 Journal article (refereed), original research
Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain
Guerrero-Toro, Cindy; Koroleva, Kseniia; Ermakova, Elizaveta; Gafurov, Oleg; Abushik, Polina; Tavi, Pasi; Sitdikova, Guzel; Giniatullin, Rashid. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research
Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes
Ryytty, Sanna; Modi, Shalem R; Naumenko, Nikolay; Shakirzyanova, Anastasia; Rahman, Muhammad Obaidur; Vaara, Miia; Suomalainen, Anu; Tavi, Pasi; Hämäläinen, Riikka H. 2022. Cells. 11: A1 Journal article (refereed), original research
Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force
Liu, Zhengye; Chaillou, Thomas; Santos Alves, Estela; Mader, Theresa; Jude, Baptiste; Ferreira, Duarte MS; Hynynen, Heidi; Cheng, Arthur J; Jonsson, William O; Pironti, Gianluigi; Andersson, Daniel C; Kenne, Ellinor; Ruas, Jorge L; Tavi, Pasi; Lanner, Johanna T. 2021. Faseb journal. 35: e22010 A1 Journal article (refereed), original research
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
Linna-Kuosmanen, Suvi; Bosch, Vanesa Tomas; Moreau, Pierre R; Bouvy-Liivrand, Maria; Niskanen, Henri; Kansanen, Emilia; Kivelä, Annukka; Hartikainen, Juha; Hippeläinen, Mikko; Kokki, Hannu; Tavi, Pasi; Levonen, Anna-Liisa; Kaikkonen, Minna U. 2021. Cardiovascular research. 117: 1339-1357 A1 Journal article (refereed), original research
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. Biomolecules. 11: 452 A1 Journal article (refereed), original research
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response
Hyttinen, Juha; Blasiak, Janusz; Tavi, Pasi; Kaarniranta, Kai. 2021. Expert opinion on therapeutic targets. 25: 773-785 A2 Review article, Literature review, Systematic review
Metabolic alterations in Parkinson's disease astrocytes
Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, ¦árka. 2020. Scientific reports. 10: 14474 A1 Journal article (refereed), original research
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues
Elkhwanky, Mahmoud-Sobhy; Kummu, Outi; Piltonen, Terhi T; Laru, Johanna; Morin-Papunen, Laure; Mutikainen, Maija; Tavi, Pasi; Hakkola, Jukka. 2020. JBMR plus. 4: 1-14 A1 Journal article (refereed), original research
Short High-Fat Diet Interferes With the Physiological Maturation of the Late Adolescent Mouse Heart
Hynynen, H; Mutikainen, M; Naumenko, N; Shakirzyanova, A; Tuomainen, T; Tavi, P. 2020. Physiological reports. 8: e14474 A1 Journal article (refereed), original research
Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes
Aatsinki, SM; Elkhwanky, MS; Kummu, O; Karpale, M; Buler, M; Viitala, P; Rinne, V; Mutikainen, M; Tavi, P; Franko, A; Wiesner, RJ; Chambers, KT; Finck, BN; Hakkola, J. 2019. Diabetes. 68: 918-931 A1 Journal article (refereed), original research
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Pölönen, P; Jawahar Deen, A; Leinonen, HM; Jyrkkänen, HK; Kuosmanen, S; Mononen, M; Jain, A; Tuomainen, T; Pasonen-Seppänen, S; Hartikainen, JM; Mannermaa, A; Nykter, M; Tavi, P; Johansen, T; Heinäniemi, M; Levonen, AL. 2019. Oncogene. 38: 7473-7490 A1 Journal article (refereed), original research
Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis
Steinz, Maarten M; Persson, Malin; Aresh, Bejan; Olsson, Karl; Cheng, Arthur J; Ahlstrand, Emma; Lilja, Mats; Lundberg, Tommy R; Rullman, Eric; Moller, Kristina Angeby; Sandor, Katalin; Ajeganova, Sofia; Yamada, Takashi; Beard, Nicole; Karlsson, Bjorn C G; Tavi, Pasi; Kenne, Ellinor; Svensson, Camilla, I; Rassier, Dilson E; Karlsson, Roger et al.. 2019. JCI insight. 4: 9 A1 Journal article (refereed), original research
Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure
Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi. 2018. Cardiovascular research. 2019; 115: 107-118 A1 Journal article (refereed), original research
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12 A1 Journal article (refereed), original research
Sarcoplasmic reticulum Ca2+ -induced Ca2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes
Karppinen, Sari; Hänninen, Sandra L; Rapila, Risto; Tavi, Pasi. 2018. Physiological reports. 6: e13522 A1 Journal article (refereed), original research
Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. 2018. Frontiers in physiology. 9: 80 A1 Journal article (refereed), original research
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036 A1 Journal article (refereed), original research
Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation
Durga Devi T, Babu M, Mäkinen P, Kaikkonen M, Heinaniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N,Tavi P, Ylä-Herttuala S. 2017. American journal of pathology. 187: 2659-2673 A1 Journal article (refereed), original research
Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction
Kaikkonen Minna U, Halonen Paavo, Liu Oscar Hsin-Fu, Turunen Tiia A, Pajula Juho, Moreau Pierre, Selvarajan Ilakya, Tuomainen Tomi, Aavik Einari, Tavi Pasi, Ylä-Herttuala Seppo. 2017. Circulation: cardiovascular genetics. 10: e001702 A1 Journal article (refereed), original research
Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder
Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Disease models and mechanisms. 10: 1089-1100 A1 Journal article (refereed), original research
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. 2017. Nucleic acids research. 2018; 46: 1124-1138 A1 Journal article (refereed), original research
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen ¦, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. Stem cell reports. 9: 1885-1897 A1 Journal article (refereed), original research
The role of cardiac energy metabolism in cardiac hypertrophy and failure
Tuomainen Tomi, Tavi Pasi. 2017. Experimental cell research. 360: 12-18 A1 Journal article (refereed), original research
Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart
Naumenko N, Huusko J, Tuomainen T, Koivumäki JT, Merentie M, Gurzeler E, Alitalo K, Kivelä R, Ylä-Herttuala S, Tavi P. 2017. Frontiers in physiology. 8: 373 A1 Journal article (refereed), original research
Myosyyttien toimintahäiriöt, kuolema ja uusiutuminen sydämen vajaatoiminnassa
Laine M, Tavi P, Lommi J. Teoksessa: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen ja Antti Saraste(toim.) , 2016. Kardiologia. s. 682-683. D2 Article in a professional book (incl. an introduction by the editor)
Neuraaliset ja endokriiniset mekanismit sydämen vajaatoiminnassa
Laine M, Tavi P, Lommi J. Teoksessa: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen ja Antti Saraste(toim.) , 2016. Kardiologia. s. 683-688. Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Peroxisome Proliferator-activated Receptor-gamma Coactivator 1 alfa1 Induces a Cardiac Excitation-contraction Coupling Phenotype Without Metabolic Remodelling
Mutikainen Maija, Tuomainen Tomi, Naumenko Nikolay, Huusko Jenni, Smirin Boris, Laidinen S, Kokki K, Hynynen H, Ylä-Herttuala S, Heinäniemi M, Ruas JL, Tavi P. 2016. Journal of physiology: london. 594: 7049-7071 A1 Journal article (refereed), original research
Potassium channel interacting protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling
Winther SV, Tuomainen T, Borup R, Tavi P, Antoons G, Thomsen MB. 2016. Scientific reports. 6: 28760 A1 Journal article (refereed), original research
Refractoriness in human atria: Time and voltage dependence of sodium channel availability
Skibsbye Lasse, Jespersen Thomas, Christ Torsten, Maleckar Mary M, van den Brink Jonas, Tavi Pasi, Koivumäki Jussi T. 2016. Journal of molecular and cellular cardiology. 101: 26-34 A1 Journal article (refereed), original research
Sydämen rakennemuutokset (remodeling) vajaatoiminnassa
Laine M, Tavi P, Lommi J. Teoksessa: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen, Antti Saraste(toim.) , 2016. Kardiologia. s. 680-682. D2 Article in a professional book (incl. an introduction by the editor)
Sydämen vajaatoiminnan hemodynaamiset häiriömekanismit
Laine M, Tavi P, Lommi J. Teoksessa: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen, Antti Saraste(toim.) , 2016. Kardiologia. s. 678-679. Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Sydänlihaksen vaurioitumisesta sydämen systoliseen vajaatoimintaan
Laine M, Tavi P, Lommi J. Teoksessa: Juhani Airaksinen, Katriina Aalto-Setälä, Juha Hartikainen, Heikki Huikuri, Mika Laine, Jyri Lommi, Pekka Raatikainen, Antti Saraste(toim.) , 2016. Kardiologia. s. 679-680. Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Ca2+-activated K+ current is essential for maintaining excitability and gene transcription in early embryonic cardiomyocytes
Karppinen S, Rapila R, Naumenko N, Tuomainen T, Koivumäki JT, Hänninen SL, Korhonen T, Tavi P. 2015. Acta physiologica. [epub 28 JUN 2015]: - A1 Journal article (refereed), original research
Calcium signalling in developing cardiomyocytes: implications for model systems and disease
Louch William E, Koivumäki Jussi T, Tavi Pasi. 2015. Journal of physiology: london. 593: 1047-1063 A1 Journal article (refereed), original research
Complex role of peroxisome proliferator activator receptors (PPARs) in nociception
Giniatullin Rashid, Bart Geneviève, Tavi Pasi. 2015. Scandinavian journal of pain. 9: 70-71 A1 Journal article (refereed), original research
Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling
Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. 2015. Proceedings of the National Academy of Sciences of the United States of America. 112: 13036-13068 A1 Journal article (refereed), original research
Generation of Functional Neuromuscular Junctions from Human Pluripotent Stem Cell Lines
Puttonen Katja A, Ruponen Marika, Naumenko Nikolay, Hovatta Outi H, Tavi Pasi, Koistinaho Jari. 2015. Frontiers in cellular neuroscience. 9:473: - A1 Journal article (refereed), original research
MicroRNA profiling of pericardial fluid samples from patients with heart failure
Kuosmanen Suvi M, Hartikainen Juha, Hippeläinen Mikko, Kokki Hannu, Levonen Anna-Liisa, Tavi Pasi. 2015. PLoS ONE. 10: e0119646 A1 Journal article (refereed), original research
WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function
Moilanen Anne-Mari, Rysä Jaana, Kaikkonen Leena, Karvonen Teemu, Mustonen Erja, Serpi Raisa, Szabó Zoltán, Tenhunen Olli, Bagyura Zsolt, Näpänkangas Juha, Ohukainen Pauli, Tavi Pasi, Kerkelä Risto, Leósdóttir Margrét, Wahlstrand Björn, Hedner Thomas, Melander Olle, Ruskoaho Heikki. 2015. PLoS ONE. 10: e0124907 A1 Journal article (refereed), original research
Endothelin-1 signalling controls early embryonic heart rate in vitro and in vivo
Karppinen S, Rapila R, Mäkikallio K, Hänninen SL, Rysä J, Vuolteenaho O, Tavi P. 2014. Acta physiologica. Volume 210, Issue 2: 369-380 A1 Journal article (refereed), original research
Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling
Ronkainen Veli-Pekka, Tuomainen Tomi, Huusko Jenni, Laidinen Svetlana, Malinen Marjo, Palvimo Jorma J, Ylä-Herttuala Seppo, Vuolteenaho Olli, Tavi Pasi. 2014. Cardiovascular research. 2014 Jan 1;101(1): 69-77 A1 Journal article (refereed), original research
In silico screening of the key cellular remodeling targets in chronic atrial fibrillation
Koivumäki Jussi T, Seemann Gunnar, Maleckar Mary M, Tavi Pasi. 2014. PLoS computational biology. 2014 May 22;10(5):e1003620.: e1003620 A1 Journal article (refereed), original research
Injected nanoparticles: The combination of experimental systems to assess cardiovascular adverse effects
Vlasova Maria A, Tarasova Olga S, Riikonen Joakim, Raula Janne, Lobach Anatoly S, Borzykh Anna A, Smirin Boris V, Kauppinen Esko I, Eletskii Alexander V, Herzig Karl-Heinz, Salonen Jarno, Tavi Pasi, Lehto Vesa-Pekka, Järvinen Kristiina. 2014. European journal of pharmaceutics and biopharmaceutics. 87: 64-72 A1 Journal article (refereed), original research
Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity
Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Stem cells. 32: 1904-1916 A1 Journal article (refereed), original research
AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy
Huusko J, Lottonen L, Merentie M, Gurzeler E, Anisimov A, Miyanohara A, Alitalo K, Tavi P, Ylä-Herttuala S. 2012. Molecular therapy. 20 (2012): 2212 - 2221 A1 Journal article (refereed), original research
Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel &#945 1C-subunit gene (Cacna1c) by DREAM translocation
Ronkainen Jarkko J, Hänninen Sandra L, Korhonen Topi, Koivumäki Jussi T, Skoumal Reka, Rautio Sini, Ronkainen Veli-Pekka, Tavi Pasi. 2011. Journal of physiology: london. 589: 2669-2686 A1 Journal article (refereed), original research
Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements
Ronkainen Veli-Pekka, Skoumal Reka, Tavi Pasi. 2011. Journal of molecular and cellular cardiology. 50: 1008-1016 A1 Journal article (refereed), original research
Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: A computational study
Koivumäki Jussi T, Korhonen Topi, Tavi Pasi. 2011. PLoS computational biology. 7: e1001067 A1 Journal article (refereed), original research
Role of reactive oxygen species in the regulation of cardiac contractility
Kubin Anna-Maria, Skoumal Réka, Tavi Pasi, Kónyi Attila, Perjés Ábel , Leskinen Hanna, Ruskoaho Heikki, Szokodi István. 2011. Journal of molecular and cellular cardiology. 50: 884-893 A1 Journal article (refereed), original research
The role of in vivo Ca²&#8314 signals acting on Ca²&#8314 -calmodulin-dependent proteins for skeletal muscle plasticity
Tavi P, Westerblad H. 2011. Journal of physiology: london. : 5021-31 A2 Review article, Literature review, Systematic review
Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice
Bruton JD, Aydin J, Yamada T, Shabalina IG, Ivarsson N, Zhang SJ, Wada M, Tavi P, Nedergaard J, Katz A et al. 2010. Journal of physiology: london. 588: 4275-4288 A1 Journal article (refereed), original research
Local Ca2+ releases enable rapid heart rates in developing cardiomyocytes
Korhonen T, Rapila R, Ronkainen V-P, Koivumäki JT & Tavi P. 2010. Journal of physiology: london. 588: 1407-1417 A1 Journal article (refereed), original research
Mitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes
Hänninen SL, Ronkainen JJ, Leskinen H & Tavi P. 2010. Cardiovascular research. 88: 75-82 A1 Journal article (refereed), original research
Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes
Tavi P, Korhonen T, Hänninen SL, Bruton JD, Lööf S, Simon A & Westerblad H. 2010. Journal of cellular physiology. 223: 376-383 A1 Journal article (refereed), original research
Model of excitation-contraction coupling of rat neonatal ventricular myocytes
Korhonen T, Hänninen SL, Tavi P. 2009. Biophysical journal. 96: 1189-1209 A1 Journal article (refereed), original research
Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling
Koivumäki JT, Korhonen T, Takalo J, Weckström M, Tavi P. 2009. Bmc physiology. 9: 16 A1 Journal article (refereed), original research

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Pasi-Petri Tavi

Research groups

Presenilin-1 ΔE9 mutation associated sarcoplasmic reticulum leak alters [Ca2+]i distribution in human iPSC-derived cardiomyocytes

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease

BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes

Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain

Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes

Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death

Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response

Metabolic alterations in Parkinson's disease astrocytes

Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues

Short High-Fat Diet Interferes With the Physiological Maturation of the Late Adolescent Mouse Heart

Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis

Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Sarcoplasmic reticulum Ca2+ -induced Ca2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes

Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction

Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

The role of cardiac energy metabolism in cardiac hypertrophy and failure

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart

Myosyyttien toimintahäiriöt, kuolema ja uusiutuminen sydämen vajaatoiminnassa

Neuraaliset ja endokriiniset mekanismit sydämen vajaatoiminnassa

Peroxisome Proliferator-activated Receptor-gamma Coactivator 1 alfa1 Induces a Cardiac Excitation-contraction Coupling Phenotype Without Metabolic Remodelling

Potassium channel interacting protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling

Refractoriness in human atria: Time and voltage dependence of sodium channel availability

Sydämen rakennemuutokset (remodeling) vajaatoiminnassa

Sydämen vajaatoiminnan hemodynaamiset häiriömekanismit

Sydänlihaksen vaurioitumisesta sydämen systoliseen vajaatoimintaan

Ca2+-activated K+ current is essential for maintaining excitability and gene transcription in early embryonic cardiomyocytes

Calcium signalling in developing cardiomyocytes: implications for model systems and disease

Complex role of peroxisome proliferator activator receptors (PPARs) in nociception

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling

Generation of Functional Neuromuscular Junctions from Human Pluripotent Stem Cell Lines

MicroRNA profiling of pericardial fluid samples from patients with heart failure

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

Endothelin-1 signalling controls early embryonic heart rate in vitro and in vivo

Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling

In silico screening of the key cellular remodeling targets in chronic atrial fibrillation

Injected nanoparticles: The combination of experimental systems to assess cardiovascular adverse effects

Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity

AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy

Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel &#945 1C-subunit gene (Cacna1c) by DREAM translocation

Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements

Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: A computational study

Role of reactive oxygen species in the regulation of cardiac contractility

The role of in vivo Ca²&#8314 signals acting on Ca²&#8314 -calmodulin-dependent proteins for skeletal muscle plasticity

Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice

Local Ca2+ releases enable rapid heart rates in developing cardiomyocytes

Mitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes

Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes

Model of excitation-contraction coupling of rat neonatal ventricular myocytes

Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling