Paula Korhonen
Senior Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Research groups
Publications
42/42 items-
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Crowley, Gerard; Kim, Minjung; O’Neill, Nathanael; Turkes, Emir; Ghasemi, Fateme; Giudice, Luca; De Schepper, Sebastiaan; Tan, Benjy JY; Maffei, Benito; SS Ferreira, Laís; Rebejac, Julie; Rueda-Carrasco, Javier; Toneva, Margarita; Fajardo, John Christian; Ge, Judy Z; Yang, Zhengyue Grace; Korhonen, Paula; Muckett, Phillip; Bennett, Damaris; Paoletti, Camille; Sow, Tammie TM; Posner, David A; Sierksma, Annerieke; Sokolova, Dimitra; Konstantellos, Viktoras; Ali, Leen; Movahedi, Kiavash; MacAskill,, 2026, Science, 393, 6807, 1-21. A1 Journal article (refereed), original research -
Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia
Ohtonen, Sohvi; Jäntti, Henna; Giudice, Luca; Mohamed, Ahmed; Shakirzyanova, Anastasia; Závodná, Táňa; Belevich, Ilya; Yan, Hong; Sabogal-Guáqueta, Angélica María; Saveleva, Liudmila; Väänänen, Mari-Anna; Rillo-Albert, Ashley; Perciballi, Elisa; Ferrari, Daniela; Tervo, Minna-Mari; Gómez-Budia, Mireia; Krejčík, Zdeněk; Aakko-Saksa, Päivi; Koistinaho, Jari; Lehtonen, Šárka; Kanninen, Katja M.; Topinka, Jan; Jokitalo, Eija; Sierra, Alejandra; Schmidt, Martina; Dolga, Amalia M.; Jalava, Pasi I.; Ko, 2025, Environment international, 199, 109467. A1 Journal article (refereed), original research -
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula, 2024, Particle and fibre toxicology, 21, 1, 6. A1 Journal article (refereed), original research -
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre,, 2024, Cell reports, 43, 3, 113862. A1 Journal article (refereed), original research -
Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja, 2023, Alzheimer's & dementia, 20, 2, 954-974. A1 Journal article (refereed), original research -
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja, 2023, Journal of extracellular vesicles, 12, 1, 12297. A1 Journal article (refereed), original research -
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja, 2023, Scientific reports, 13, 1, 22118. A1 Journal article (refereed), original research -
Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)
Liu, Jie; van Beusekom, Heleen; Bu, Xian‐Le; Chen, Gong; Henrique Rosado de Castro, Paulo; Chen, Xiaochun; Chen, Xiaowei; Clarkson, Andrew N.; Farr, Tracy D.; Fu, Yuhong; Jia, Jianping; Jolkkonen, Jukka; Kim, Woojin Scott; Korhonen, Paula; Li, Shen; Liang, Yajie; Liu, Guang‐Hui; Liu, Guiyou; Liu, Yu‐Hui; Malm, Tarja; Mao, Xiaobo; Oliveira, Joaquim Miguel; Modo, Mike M.; Ramos‐Cabrer, Pedro; Ruscher, Karsten; Song, Weihong; Wang, Jun; Wang, Xuanyue; Wang, Yun; Wu, Haitao; Xiong, Lize; Yang, Yi; Y, 2023, Neuroprotection, 1, 2, 84-98. B1 Non-refereed journal articles -
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita, 2023, Embo reports, 24, 7, e56467. A1 Journal article (refereed), original research -
Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna, 2022, Journal of biological chemistry, 298, 3, 101721. A1 Journal article (refereed), original research